Hub : Traits :

Number of full sisters

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 4 2051518 3451960 1 1 3.8e-07 4.5e-06 4.1e-05 20 TNIP2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Ovarian Cancer 7.59 1 0 0 0 1 TNIP2
Lupus 4.22 1 0 0 0 1 TNIP2
Primary Biliary Cirrhosis 3.06 1 0 0 0 1 TNIP2
Blood Eosinophil Count 1.19 1 0 0 0 1 TNIP2
Blood Platelet Count 0.84 1 0 0 0 1 TNIP2
Blood Red Count 0.70 1 0 0 0 1 TNIP2
Waist Hip Ratio (WHR) 1.11 1 0 0 0 1 TNIP2
Systolic Blood Pressure 3.28 1 0 0 0 1 TNIP2
Cardiovascular Disease 3.69 1 0 0 0 1 TNIP2
Tanning 0.73 1 0 0 0 1 TNIP2
Systolic blood pressure, automated reading 3.55 1 0 0 0 1 TNIP2
Impedance of leg (right) 1.10 1 0 0 0 1 TNIP2
Trunk fat percentage 1.03 1 0 0 0 1 TNIP2
Average weekly fortified wine intake 11.76 1 0 0 0 1 TNIP2
Fed-up feelings 2.64 1 0 0 0 1 TNIP2
High blood pressure 5.59 1 0 0 0 1 TNIP2
Medication: Atenolol 13.26 1 0 0 0 1 TNIP2
Impedance of leg (left) 1.02 1 0 0 0 1 TNIP2
Hair/balding pattern: Pattern 2 3.22 1 0 0 0 1 TNIP2
Had menopause 3.51 1 0 0 0 1 TNIP2
Hayfever/allergic rhinitis (self-reported) 3.64 1 0 0 0 1 TNIP2
Illnesses of siblings 3.28 1 0 0 0 1 TNIP2
Neuroticism score 2.43 1 0 0 0 1 TNIP2
Impedance of arm (right) 1.65 1 0 0 0 1 TNIP2
Serious illness, injury or assault of a close relative in last 2 years 3.33 1 0 0 0 1 TNIP2
Impedance of arm (left) 2.38 1 0 0 0 1 TNIP2
Breastfed as a baby 5.19 1 0 0 0 1 TNIP2
Birth weight of first child 3.38 1 0 0 0 1 TNIP2
Medication: Paracetamol 2.88 1 0 0 0 1 TNIP2
Medication for cholesterol, blood pressure or diabetes 3.19 1 0 0 0 1 TNIP2
Glaucoma (self-reported) 7.25 1 0 0 0 1 TNIP2
Number of children fathered 6.43 1 0 0 0 1 TNIP2
Emphysema/chronic bronchitis 5.47 1 0 0 0 1 TNIP2
Medication: Blood pressure 5.62 1 0 0 0 1 TNIP2
Hypertension (Self-reported) 5.01 1 0 0 0 1 TNIP2
Average weekly red wine intake 3.80 1 0 0 0 1 TNIP2
Miserableness 3.72 1 0 0 0 1 TNIP2
Guilty feelings 10.59 1 0 0 0 1 TNIP2
Financial situation satisfaction 4.14 1 0 0 0 1 TNIP2
Eye problems/disorders: Glaucoma 7.29 1 0 0 0 1 TNIP2
Medication: Blood pressure 4.18 1 0 0 0 1 TNIP2
Age started oral contraceptive pill 5.42 1 0 0 0 1 TNIP2
Vascular/heart problems diagnosed by doctor 4.29 1 0 0 0 1 TNIP2
Impedance of whole body 2.10 1 0 0 0 1 TNIP2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.26
GTEx Adipose Visceral Omentum 0 0.0000 1.23
GTEx Adrenal Gland 0 0.0000 1.21
GTEx Artery Aorta 0 0.0000 1.22
GTEx Artery Coronary 0 0.0000 1.24
GTEx Artery Tibial 0 0.0000 1.25
GTEx Brain Caudate basal ganglia 0 0.0000 1.15
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.28
GTEx Brain Cerebellum 0 0.0000 1.24
GTEx Brain Cortex 0 0.0000 1.23
GTEx Brain Frontal Cortex BA9 0 0.0000 1.22
GTEx Brain Hippocampus 0 0.0000 1.32
GTEx Brain Hypothalamus 0 0.0000 1.15
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.25
GTEx Brain Putamen basal ganglia 0 0.0000 1.26
GTEx Breast Mammary Tissue 0 0.0000 1.23
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.24
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.18
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.17
GTEx Cells Transformed fibroblasts 0 0.0000 1.20
GTEx Colon Sigmoid 0 0.0000 1.25
GTEx Colon Transverse 0 0.0000 1.24
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.25
GTEx Esophagus Mucosa 0 0.0000 1.23
GTEx Esophagus Muscularis 0 0.0000 1.24
GTEx Heart Atrial Appendage 0 0.0000 1.21
GTEx Heart Left Ventricle 0 0.0000 1.25
GTEx Liver 0 0.0000 1.23
GTEx Lung 0 0.0000 1.29
GTEx Muscle Skeletal 0 0.0000 1.16
GTEx Nerve Tibial 0 0.0000 1.19
GTEx Ovary 0 0.0000 1.26
GTEx Pancreas 0 0.0000 1.28
GTEx Pituitary 0 0.0000 1.22
GTEx Prostate 0 0.0000 1.33
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.25
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.26
GTEx Small Intestine Terminal Ileum 0 0.0000 1.20
GTEx Spleen 0 0.0000 1.13
GTEx Stomach 0 0.0000 1.24
GTEx Testis 0 0.0000 1.24
GTEx Thyroid 0 0.0000 1.23
GTEx Uterus 0 0.0000 1.22
GTEx Vagina 0 0.0000 1.30
GTEx Whole Blood 0 0.0000 1.24
METSIM Adipose 0 0.0000 1.20
NTR Blood 0 0.0000 1.22
ROSMAP Brain Pre-frontal Cortex 1 0.0228 1.26
YFS Blood 0 0.0000 1.16
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.26
TCGA Breast Tumor 0 0.0000 1.27
TCGA Breast Normal 0 0.0000 1.21
TCGA Ovarian Tumor 0 0.0000 1.20
TCGA Prostate Tumor 0 0.0000 1.25