Hub : Genes

MLTK

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Muscularis 0.1200 0.0480 8.3e-03 0.007 NA 0.011 NA 0.008 1.1e-01 NA 7.1e-02 NA 9.9e-02
2 GTEx Testis 0.2720 0.0630 2.2e-06 0.162 NA 0.150 NA 0.152 1.1e-07 NA 3.4e-07 NA 2.9e-07
3 GTEx Thyroid 0.1130 0.0410 2.5e-03 -0.004 NA 0.000 NA -0.003 1.0e+00 NA 3.0e-01 NA 7.4e-01
4 METSIM Adipose 0.0601 0.0222 2.0e-03 -0.001 0.018 0.007 0.018 -0.002 6.7e-01 0.00095 2.7e-02 8.2e-04 1.0e+00
5 ROSMAP Brain Pre-frontal Cortex 0.0680 0.0213 1.1e-04 0.031 0.029 0.049 0.036 0.043 6.4e-05 0.00011 6.2e-07 1.8e-05 3.1e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.3 0.5 1.3 0.2 -1.1 -0.8 -0.6 0.3
Bipolar Disorder or Schizophrenia 0.6 1.5 3.2 -0.2 1.5 -1.3 0.3 1.8
Depressed Affect (Nagel 2018) 1.5 3.1 6.2 -2.5 1.7 -1.3 -1.0 1.9
Depression (Nagel 2018) 1.2 1.8 3.2 -1.6 1.3 -1.8 -0.2 1.2
Intelligence (Savage-Jansen 2018) 0.9 2.6 9.3 -0.0 -3.0 1.2 -1.5 -0.0
Neuroticism (Nagel 2018) 0.9 2.2 3.1 -1.7 0.7 -1.8 -1.6 1.3
Schizophrenia (2018) 1.4 2.9 8.4 -0.4 2.9 -1.1 0.8 2.0
Schizophrenia vs Biploar Disorder 1.6 2.1 4.9 -0.3 1.8 -2.2 1.5 0.5
Worry (Nagel 2018) 0.6 1.3 2.9 -1.7 0.1 -1.3 -0.2 1.4
Alzheimer’s Disease (in mother) 0.7 0.8 2.1 -0.2 1.3 -0.5 0.1 1.5
Alzheimer’s Disease (in father) 0.1 0.1 0.3 0.5 0.4 0.3 -0.2 -0.1
Alzheimer’s Disease (including proxy) 0.5 0.7 2.2 0.3 1.5 0.2 -0.1 1.1
Crohns Disease (2017) 2.2 4.7 9.1 -2.1 2.7 -3.0 -1.1 1.2
Irritable Bowel Disease (IBD) 1.0 2.3 2.6 -1.4 1.6 -1.6 -1.4 1.6
Ulcerative Colitis (UC) 0.3 0.5 0.9 -0.1 -0.7 0.4 -0.9 0.9
Major Depression (MDD) 2.3 2.8 6.3 -1.2 -0.9 -2.3 -2.5 -0.5
Reaction Time 0.4 0.8 1.2 1.0 -1.1 1.0 1.0 -0.0
Verbal and Numeric Reasoning (VNR) 0.5 1.2 5.4 -0.3 -2.3 0.2 -0.6 0.3
Breast Cancer 1.4 3.4 7.5 1.6 -1.8 1.3 1.4 -2.7
Ovarian Cancer 2.9 3.8 9.3 3.0 -1.4 1.2 -0.2 -2.5
Prostate Cancer 1.5 2.1 3.4 1.7 -1.8 0.8 0.9 -1.7
Age at First Birth 2.8 4.1 9.4 1.3 -3.1 -0.0 2.3 -2.0
Bipolar Disorder (2011) 1.0 0.9 2.1 -1.3 -0.0 -0.9 -0.1 1.5
Body Mass Index (BMI) (2010) 2.0 2.7 5.5 -2.3 1.3 -1.0 -0.3 2.3
Coronary Artery Disease (CAD) 0.6 0.7 1.9 -1.0 0.7 -0.1 -1.4 -0.1
Crohns Disease (2012) 3.0 4.8 9.4 -2.5 2.8 -3.1 -0.7 0.7
Mean Putamen Volume 0.5 0.6 2.1 0.6 0.6 -0.1 0.2 -1.5
Fasting Glucose 0.5 0.6 2.2 -0.7 0.6 0.4 0.2 1.5
HbA1C 0.6 0.6 2.2 1.5 -0.1 0.6 0.3 -0.7
HDL Cholesterol 0.3 0.5 0.8 0.3 0.9 0.5 0.9 0.9
LDL Cholesterol 0.2 0.3 0.9 -0.2 0.0 -0.8 -0.3 -0.9
Lupus 2.0 3.0 4.5 2.0 -1.2 1.0 -2.1 -2.0
Neuroticism (2016) 0.7 1.0 4.0 0.2 0.0 -2.0 -0.8 0.0
Primary Biliary Cirrhosis 1.7 2.4 4.9 1.6 -1.5 -0.3 1.6 -2.2
Rheumatoid Arthritis 0.1 0.1 0.2 -0.3 0.0 0.4 -0.4 -0.3
Schizophrenia (2014) 1.7 3.8 6.5 -1.1 2.5 -2.3 0.3 2.4
Triglycerides 0.2 0.3 0.6 0.1 -0.6 -0.8 0.7 -0.2
Type 2 Diabetes (T2D) (2012) 1.5 1.7 6.8 -0.7 0.9 -2.6 -0.3 0.6
Ulcerative Colitis 0.2 0.4 1.1 -0.1 0.5 0.3 -0.5 1.0
Blood Eosinophil Count 0.1 1.1 2.1 -1.4 0.2 -1.3 -1.3 0.3
Blood Platelet Count 0.2 2.8 6.2 2.5 -1.9 -0.5 -0.2 -2.0
Blood Red Count 0.3 3.0 6.5 1.4 -2.3 0.9 -0.8 -2.5
Blood White Count 0.2 1.3 3.0 0.2 -1.4 1.2 -1.7 -0.4
Heel T-Score 0.1 0.5 1.1 0.3 1.0 0.4 0.2 1.0
BMI 2.3 13.3 15.8 -4.0 3.8 -3.4 -3.3 3.7
Height 0.1 2.4 3.8 1.0 -1.8 2.0 0.6 -1.9
Waist Hip Ratio (WHR) 0.2 0.9 2.3 -0.3 -1.5 -0.3 0.4 -1.3
Systolic Blood Pressure 1.7 8.6 17.8 3.1 -4.2 -0.0 -0.9 -3.9
Smoking Status 4.7 11.2 21.5 -3.5 4.6 -2.8 -0.5 3.8
Allergy or Eczema 1.4 3.8 11.3 1.6 -3.4 1.6 0.7 -1.4
Cardiovascular Disease 0.3 1.0 2.9 0.6 -1.0 -0.7 -1.7 -0.0
Hypothyroidism (self reported) 0.4 0.9 2.9 0.1 -0.7 0.7 1.7 0.7
Respiratory disease 0.2 0.4 1.5 1.2 0.3 0.5 0.1 -0.1
Type 2 Diabetes (T2D) (2018) 1.1 2.1 7.0 -1.7 0.2 -0.3 -0.8 2.6
Lung FEV1/FVC ratio 1.9 9.5 35.5 0.4 -6.0 1.3 0.5 -3.1
Lung FVC 0.4 2.3 4.0 2.0 -1.7 0.5 0.5 -2.0
Neuroticism 0.8 1.9 4.2 -2.1 0.7 -0.9 -0.9 1.8
Chronotype (morning person) 2.0 4.7 12.6 -1.6 3.5 -2.2 -0.5 1.8
Hair Pigment 0.0 0.1 0.2 0.5 0.3 -0.1 -0.0 -0.3
Tanning 0.1 0.8 1.7 0.9 -1.3 1.0 -0.6 -0.6
Hand grip strength (left) 2.3 6.1 11.5 2.7 -1.3 1.8 3.4 -2.6
Number of treatments/medications taken 1.3 2.4 4.4 -1.8 -0.2 0.4 -2.0 2.1
Average weekly spirits intake 0.9 1.1 2.7 -0.1 -1.0 -1.6 -0.7 -1.2
Sensitivity / hurt feelings 0.3 0.5 0.8 -0.1 0.8 -0.8 -0.9 -0.4
Frequency of depressed mood in last 2 weeks 0.9 1.3 1.9 -1.4 0.8 -1.4 -0.8 1.2
Hearing difficulty/problems: Yes 1.4 2.2 3.9 -1.8 2.0 -0.7 -1.7 0.5
Relative age of first facial hair 0.2 0.4 1.1 -0.5 -0.1 -0.0 1.1 0.7
Other serious medical condition/disability diagnosed by doctor 1.2 1.6 7.3 -0.7 -0.1 -0.1 -2.7 -0.0
Ever used hormone-replacement therapy (HRT) 0.7 0.9 2.3 -0.9 1.5 -0.3 -0.3 1.1
Ever had hysterectomy (womb removed) 2.2 2.5 3.7 -1.8 1.4 -1.9 -1.7 0.9
Systolic blood pressure, automated reading 1.9 5.5 13.6 2.0 -3.7 1.0 -1.1 -2.8
Eye problems/disorders: Diabetes related eye disease 1.8 2.0 4.9 -2.2 0.8 -0.6 -0.7 1.9
Angina 0.6 0.8 1.7 0.6 -1.0 -1.0 -1.3 -0.5
Medication for hormone replacement therapy 1.2 1.4 4.3 -1.3 0.4 0.1 -0.9 2.1
Vitamin and mineral supplements 2.0 2.7 10.0 0.7 -0.6 -0.0 3.2 -1.5
Supplements: Zinc 0.2 0.2 0.4 -0.3 0.6 -0.5 0.4 0.1
Medication: Co-codamol 0.7 0.8 2.8 -0.1 0.1 -0.2 -1.7 1.1
Medication: Metformin 1.5 2.1 3.8 -2.0 1.0 -0.8 -1.0 1.9
Diabetes (father) 0.4 0.4 0.7 0.8 -0.4 0.6 -0.8 -0.6
Diabetes (mother) 0.2 0.3 0.6 -0.7 -0.4 -0.3 -0.2 0.8
Severe depression (siblings) 0.5 0.6 0.9 -0.8 0.1 -0.9 -0.9 0.8
Pack years adult smoking proportion 1.3 2.0 3.0 -1.2 1.7 1.2 -1.3 1.5
Impedance of leg (right) 0.6 2.9 5.6 2.4 -1.9 0.4 0.3 -2.2
Leg fat-free mass (left) 0.4 2.1 5.6 -2.4 1.5 -0.0 -0.9 1.4
Trunk fat percentage 1.8 7.3 14.3 -3.1 2.1 -1.8 -3.8 2.2
Hand grip strength (right) 2.8 7.5 9.9 3.1 -2.0 2.7 2.8 -2.9
Townsend deprivation index at recruitment 4.8 6.7 19.0 -1.6 4.4 -1.4 -1.9 2.6
Current tobacco smoking 1.9 3.1 6.2 -1.8 1.9 -1.4 -0.6 2.5
Average weekly fortified wine intake 0.7 0.8 3.0 0.2 -1.7 0.3 -0.8 -0.7
Maternal smoking around birth 0.8 1.1 2.7 -0.9 1.3 -0.3 -1.6 0.6
Fed-up feelings 0.7 1.3 1.9 -1.4 0.7 -1.2 -1.1 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 1.6 -1.2 1.3 -1.0 -0.4 0.7
Relative age voice broke 0.1 0.2 0.4 0.5 -0.6 0.4 0.5 0.2
Taking other prescription medications 0.5 0.8 2.0 -0.6 -0.4 0.8 -1.4 0.9
Age when periods started (menarche) 0.1 0.3 0.7 0.8 -0.5 -0.2 0.4 -0.4
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.9 -0.5 1.1 -1.4 0.3 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.2 0.0 0.6 1.1 1.0 0.1
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.1 -0.0 -0.5 1.1 -0.6 -0.4
Qualifications: CSEs or equivalent 0.2 0.2 0.5 0.6 0.2 0.1 -0.7 -0.5
Serious illness, injury or assault to yourself 1.2 1.4 3.3 -1.8 -0.6 0.6 -1.0 1.4
High blood pressure 0.5 1.3 5.2 0.1 -1.0 -0.1 -2.3 0.4
Hayfever, allergic rhinitis or eczema 1.8 3.8 7.5 2.1 -2.7 1.8 1.2 -1.5
Multivitamins +/- minerals 0.8 1.0 2.4 -0.3 -0.2 0.1 -1.5 1.5
Stomach or abdominal pain in last month 0.7 0.9 3.2 -0.6 1.8 0.0 -0.3 1.0
Supplements: Glucosamine 0.1 0.2 0.3 -0.2 -0.5 -0.4 0.2 -0.6
Diverticular disease/diverticulitis (self-reported) 2.5 2.9 3.5 -1.9 1.8 -1.6 -1.9 1.4
Medication: Atenolol 0.2 0.2 0.8 0.2 -0.6 -0.3 0.9 -0.1
Medication: Levothyroxine sodium 0.5 0.8 1.4 -0.6 -0.8 0.8 1.0 1.2
Sitting height 0.3 2.0 5.2 1.0 -2.3 1.0 0.1 -1.6
Chronic bronchitis/emphysema (father) 1.2 1.4 6.2 0.1 2.5 -0.8 -0.0 -0.2
High blood pressure (mother) 0.2 0.3 1.0 -0.3 -0.7 1.0 0.3 -0.1
Body mass index (BMI) 2.3 9.6 16.1 -4.0 3.3 -1.9 -2.9 3.0
Impedance of leg (left) 0.5 2.6 5.5 2.4 -2.0 0.1 -0.2 -1.9
Leg predicted mass (left) 0.4 2.3 6.0 -2.4 1.5 -0.0 -0.9 1.5
Trunk fat mass 1.7 7.4 11.8 -3.4 2.4 -1.6 -3.4 2.4
Waist circumference 1.5 5.6 13.0 -3.6 2.0 -1.2 -2.4 2.0
Number of incorrect matches in round 0.4 0.7 2.8 -0.6 1.7 0.5 -0.5 0.1
Past tobacco smoking 3.7 6.9 18.1 2.8 -4.3 1.9 0.7 -2.1
Alcohol usually taken with meals 2.9 4.7 6.9 2.5 -2.4 1.6 1.4 -2.6
Nervous feelings 0.6 1.2 2.4 -1.5 -0.1 -1.6 -1.1 0.3
Frequency of tenseness / restlessness in last 2 weeks 2.1 3.2 6.1 -2.5 1.8 -0.5 -1.0 2.4
Hearing difficulty/problems with background noise 1.4 2.3 4.1 -1.3 2.0 -2.0 -1.2 0.6
Hair/balding pattern: Pattern 2 0.4 0.5 1.6 -1.3 -0.9 0.1 -0.3 0.5
Had menopause 0.4 0.5 1.3 1.1 -0.5 0.2 0.4 -0.9
Had other major operations 0.9 1.1 3.0 -1.0 0.9 -0.6 0.2 1.7
Forced vital capacity (FVC) 0.4 1.6 2.4 1.1 -1.6 0.7 1.3 -1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.8 0.1 -0.0 0.9 0.7 -0.2
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 2.7 -0.7 -0.2 0.4 -1.6 0.3
Qualifications: None of the above 0.1 0.3 1.1 -0.5 1.1 -0.1 0.1 0.4
Financial difficulties in last 2 years 0.4 0.5 2.0 -0.2 0.3 0.1 0.7 1.4
Mouth/teeth dental problems 2.8 4.3 8.9 3.0 -1.8 1.1 1.3 -2.4
Heart attack 1.1 1.4 3.5 -0.9 -1.9 0.1 -1.6 0.2
Allergy 1.3 3.0 5.8 -1.4 2.4 -2.1 -1.2 1.1
Pain all over the body in last month 1.5 1.7 4.2 -1.1 1.2 -0.9 -2.0 0.9
Diabetes (self-reported) 1.4 2.2 4.6 -2.0 1.2 -0.7 -0.4 2.1
Hayfever/allergic rhinitis (self-reported) 2.2 2.9 7.6 2.8 -1.2 0.1 0.7 -2.2
Medication: Ramipril 0.3 0.4 0.7 -0.7 0.1 -0.4 -0.8 0.7
Medication: Simvastatin 0.5 0.8 1.6 -0.9 -1.2 0.3 -1.2 0.1
Fluid intelligence score 0.8 1.7 5.8 -0.2 -2.4 1.4 0.9 0.4
Illnesses of siblings 0.9 1.3 3.3 -1.4 -0.2 0.5 1.8 0.9
Neuroticism score 1.3 2.6 4.5 -2.1 0.5 -1.2 -2.0 1.7
Weight 1.3 6.2 12.6 -3.6 2.3 -0.9 -2.5 2.5
Impedance of arm (right) 0.7 3.1 5.9 2.3 -2.4 0.9 -0.3 -1.9
Arm fat percentage (right) 2.3 9.1 14.1 -3.8 2.7 -1.8 -3.5 3.0
Trunk fat-free mass 0.3 1.8 4.9 -2.2 1.3 0.2 -0.4 1.5
Hip circumference 1.6 6.8 12.4 -3.5 2.3 -1.3 -2.7 2.7
Time employed in main current job 2.5 2.8 7.3 2.7 -1.5 -0.1 0.5 -2.1
Alcohol intake versus 10 years previously 1.2 1.8 3.0 1.3 1.6 -1.7 0.4 -1.3
Father’s age at death 1.1 1.5 3.0 1.4 -1.5 1.7 0.2 -0.7
Worrier / anxious feelings 0.6 1.1 2.5 -1.1 -0.9 -0.7 -1.6 0.7
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.7 3.0 -1.1 -0.7 1.3 -1.7 1.5
Falls in the last year 3.2 4.3 12.6 -1.8 2.1 -0.3 -3.5 1.0
Hair/balding pattern: Pattern 3 0.4 0.6 1.8 1.1 0.1 0.0 -0.4 -1.4
Number of live births 0.5 0.7 2.4 -0.1 0.6 -0.4 -1.6 -0.6
Forced expiratory volume in 1-second (FEV1) 1.0 3.3 8.6 1.1 -2.9 1.3 0.4 -2.2
Pulse rate 0.7 1.1 2.2 1.1 -0.7 -1.5 0.6 -1.2
Happiness 0.7 0.8 1.4 -0.8 -1.2 0.6 -0.7 1.0
Noisy workplace 2.7 3.3 9.7 0.5 3.1 -2.5 0.7 -0.3
Qualifications: A levels/AS levels or equivalent 1.8 4.1 12.8 0.3 -3.6 1.2 2.4 0.6
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.8 5.0 -1.6 -0.8 0.2 -1.0 2.2
Mouth/teeth dental problems: Dentures 0.9 1.5 3.0 -1.1 1.7 -1.0 -0.9 1.2
Asthma 0.1 0.2 0.7 0.4 0.8 -0.3 0.2 -0.1
Medication: Ibuprofen (e.g. Nurofen) 2.4 3.0 5.3 -2.3 1.6 -2.1 -0.8 1.4
Medication: Cholesterol lowering 1.0 1.5 3.5 -1.7 -0.7 -0.4 -0.9 1.9
Depression (self-reported) 1.8 2.1 5.1 -2.2 0.2 -1.0 -1.9 0.9
Medication: Lansoprazole 2.0 2.2 5.1 -0.7 0.5 -2.2 -2.2 0.7
Prospective memory result 0.8 1.0 2.1 -1.4 1.4 -0.8 -0.5 -0.0
Lung cancer (father) 1.4 1.6 3.7 1.0 -1.7 1.9 0.3 -0.8
Illnesses of mother 0.6 0.7 1.6 0.0 0.8 -1.3 -0.8 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 1.1 3.6 10.8 1.1 -3.3 0.7 0.4 -2.3
Pulse wave Arterial Stiffness index 2.2 2.6 7.1 1.4 -2.7 1.2 -0.3 -1.5
Impedance of arm (left) 0.5 2.4 4.7 2.2 -2.0 0.6 -0.5 -1.6
Arm fat mass (right) 2.2 8.9 14.7 -3.8 2.8 -1.6 -3.5 2.8
Trunk predicted mass 0.3 1.6 4.6 -2.1 1.2 0.3 -0.4 1.4
Standing height 0.2 1.5 3.2 0.5 -1.8 1.6 0.5 -1.2
Length of working week for main job 1.0 1.1 2.7 0.6 -1.0 1.0 0.8 -1.6
Exposure to tobacco smoke at home 1.3 1.5 4.5 0.3 2.1 -1.1 -1.1 0.7
Breastfed as a baby 3.7 4.5 13.2 -0.8 -2.7 3.6 1.2 0.5
Tense / ‘highly strung’ 2.3 3.9 5.8 -2.0 2.4 -2.1 -1.3 1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 3.1 4.8 12.7 -2.4 0.5 -1.1 -3.6 2.0
Hair/balding pattern: Pattern 4 0.3 0.6 3.0 0.4 0.1 -0.2 0.1 1.7
Birth weight of first child 0.2 0.3 0.9 -0.2 0.2 0.9 -0.6 0.4
Peak expiratory flow (PEF) 0.3 0.6 2.2 0.4 -0.8 0.4 0.1 -1.5
Pulse wave reflection index 0.8 1.0 2.3 -0.9 -0.8 1.1 -1.5 0.4
Ever highly irritable/argumentative for 2 days 1.8 2.2 4.0 -1.6 1.4 -0.6 -1.3 2.0
Loud music exposure frequency 0.9 1.0 2.9 -1.7 0.9 0.4 -0.1 1.2
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 3.3 0.2 -1.8 0.1 -0.1 -0.5
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 4.4 -2.1 0.8 -0.9 -0.3 1.4
Blood clot in the leg (DVT) 1.4 1.9 5.4 0.3 -2.3 0.3 -1.8 -0.7
Medication: Paracetamol 0.4 0.7 1.3 -1.0 1.0 -0.4 -1.1 0.4
Headache pain in last month 1.0 1.8 4.8 -1.5 2.2 0.5 -0.2 1.1
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.6 1.1 0.2 0.7 0.4 -1.2
Glaucoma (self-reported) 0.5 0.6 1.9 0.2 -0.9 0.0 -1.4 -0.7
Gout (self-reported) 0.5 0.7 1.8 0.2 -1.1 1.3 0.2 0.5
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 1.7 -0.4 -0.6 0.6 1.3 1.0
Medication: Amlodipine 0.8 1.2 2.2 -1.4 0.5 0.3 -1.1 1.5
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.1 0.7 1.4 -0.3 1.1 -0.3
Birth weight 0.2 0.4 1.1 -0.8 0.6 0.2 0.1 1.1
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.1 -0.1 -1.1 -0.7 -0.9 -0.7
High blood pressure (siblings) 1.2 1.8 3.5 1.9 -1.1 -0.5 -1.0 -1.7
Forced vital capacity (FVC), Best measure 0.5 2.0 5.8 1.2 -2.4 0.5 0.6 -1.4
Body fat percentage 2.0 7.8 13.8 -3.3 2.2 -1.8 -3.7 2.5
Leg fat percentage (right) 1.8 6.6 10.0 -3.2 2.3 -1.4 -3.1 2.4
Arm fat-free mass (right) 0.4 1.8 5.2 -2.3 1.4 -0.1 -0.8 1.2
Exposure to tobacco smoke outside home 0.7 0.9 2.2 -0.0 1.5 0.9 -1.3 -0.2
Comparative body size at age 10 0.2 0.5 1.3 -0.5 -0.6 1.1 0.7 -0.3
Number of full brothers 0.5 0.7 2.9 0.3 0.0 1.7 -0.5 0.3
Worry too long after embarrassment 0.3 0.6 1.3 0.6 -1.1 0.3 -1.1 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 4.5 5.8 11.5 -2.6 2.2 -1.8 -1.7 3.4
Wheeze or whistling in the chest in last year 0.4 0.8 3.0 -0.3 1.7 0.7 0.5 0.3
Number of children fathered 1.5 1.6 7.8 -0.1 0.4 0.5 -2.8 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 2.6 1.6 -1.5 0.8 0.2 -0.7
Age at first live birth 5.5 9.8 27.5 2.3 -5.2 1.6 3.2 -1.9
Pulse wave peak to peak time 1.9 2.2 6.4 -1.2 2.5 -1.0 0.6 1.4
Health satisfaction 1.7 2.2 8.0 -0.3 -0.7 -0.1 -2.8 1.6
Shortness of breath walking on level ground 0.4 0.4 1.3 -0.1 0.5 -0.4 -0.7 1.1
Qualifications: College or University degree 1.2 3.6 12.8 0.1 -3.6 2.0 1.2 -0.3
Eye problems/disorders: None of the above 0.6 0.7 2.2 0.9 0.6 0.2 1.5 -0.1
Mouth/teeth dental problems: Loose teeth 1.2 1.5 5.2 -2.3 0.7 -0.4 -0.2 1.3
Emphysema/chronic bronchitis 0.8 0.9 3.9 -0.4 -0.4 2.0 0.4 0.6
Medication for pain relief, constipation, heartburn 2.9 5.0 11.1 3.3 -1.4 1.4 1.3 -2.9
Neck or shoulder pain in last month 0.9 1.3 3.3 -1.8 0.9 0.4 0.2 1.4
Medication: Blood pressure 0.4 0.8 1.4 -1.2 -0.3 -0.2 -1.0 1.1
Angina (self-reported) 0.6 0.7 1.9 0.3 -0.6 -1.2 -1.4 -0.3
Migraine (self-reported) 1.7 2.2 4.4 1.8 -1.1 0.8 1.2 -2.1
Medication: Ibuprofen 2.3 2.7 3.6 -1.9 1.9 -1.8 -0.1 1.8
Medication: Allopurinol 0.3 0.3 0.7 0.6 -0.8 0.8 -0.2 0.3
Medication: Omeprazole 2.3 2.7 5.3 -1.4 0.8 0.9 -2.3 2.3
Medication: Seretide 50 evohaler 1.3 1.5 3.1 -1.4 0.9 -1.2 -1.7 0.4
Mean time to correctly identify matches 0.5 0.9 2.1 1.3 -1.4 0.5 0.8 0.1
Heart disease (mother) 0.8 0.9 2.3 -0.4 -0.5 1.5 -1.1 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.4 0.1 0.0 0.5 -0.5 0.6
Whole body fat mass 1.8 7.7 11.8 -3.4 2.5 -1.6 -3.4 2.5
Leg fat mass (right) 2.0 7.8 13.0 -3.6 2.8 -1.5 -3.1 2.6
Arm predicted mass (right) 0.4 2.1 5.6 -2.4 1.6 -0.3 -1.0 1.2
Pulse rate, automated reading 1.0 3.2 12.3 0.3 -3.5 1.1 0.3 -1.5
Alcohol intake frequency. 2.1 4.8 11.2 -1.5 3.4 -1.2 -2.3 2.0
Comparative height size at age 10 0.1 0.5 2.1 -0.1 -0.2 1.4 -0.6 0.4
Number of full sisters 1.3 1.6 7.1 0.1 -0.6 -0.3 -2.7 0.6
Suffer from ‘nerves’ 0.4 0.7 1.3 -0.8 -1.2 -0.4 -1.0 0.4
Overall health rating 2.5 5.3 10.3 -2.7 -0.1 -0.1 -3.2 3.0
Chest pain or discomfort 1.2 1.8 3.8 -1.7 0.5 1.3 0.3 2.0
Had major operations 0.5 0.6 1.2 0.8 -0.6 1.1 -0.8 -0.4
Age at last live birth 4.6 6.7 15.1 1.7 -3.9 2.2 3.1 -1.1
Family relationship satisfaction 1.2 1.5 3.7 -0.4 -1.9 1.8 0.0 0.4
Leg pain on walking 1.8 2.2 7.7 -0.9 0.9 -1.4 -2.8 0.0
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.0 2.0 -0.5 0.9 -1.2 -0.7 1.4
Commuting to job workplace: Car/motor vehicle 1.7 2.0 5.2 0.4 -2.1 2.3 0.2 -0.1
Illness, injury, bereavement, stress in last 2 years 0.1 0.2 0.4 -0.3 0.6 -0.6 0.1 -0.1
Medication: Aspirin 2.3 3.1 5.4 -2.3 1.1 -1.5 -1.2 2.3
Supplements: Vitamin C 0.6 0.7 1.7 0.3 1.3 0.0 -0.9 0.9
Knee pain experienced in last month 1.9 3.0 6.4 -1.0 2.5 -0.8 -0.7 2.5
Hypertension (Self-reported) 0.5 1.3 5.4 0.2 -1.0 0.0 -2.3 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.6 1.9 3.7 -1.1 1.4 -0.2 -1.9 1.5
Illnesses of father: Heart disease 0.2 0.3 0.7 0.2 -0.8 0.5 -0.4 -0.7
Illnesses of siblings: Diabetes 0.2 0.3 0.9 0.4 -0.0 -0.9 -0.5 0.2
Smoking status: Previous 2.9 4.3 10.7 -2.2 3.3 -1.9 -0.1 1.6
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 3.8 -0.3 -0.6 0.2 1.9 0.5
Whole body fat-free mass 0.4 2.2 5.8 -2.4 1.5 0.0 -0.7 1.5
Leg fat-free mass (right) 0.4 2.2 5.4 -2.3 1.4 -0.1 -1.0 1.6
Arm fat percentage (left) 2.5 9.8 14.9 -3.9 2.9 -2.0 -3.6 3.0
Average weekly red wine intake 0.4 0.6 1.7 0.3 -1.0 1.3 0.5 -0.6
Handedness (chirality/laterality): Left-handed 1.5 1.8 5.2 -1.2 0.3 -2.3 -0.5 1.4
Mood swings 2.9 5.2 7.8 -2.2 1.9 -2.1 -2.8 2.4
Loneliness, isolation 0.7 1.0 2.3 -1.5 0.9 -0.0 -0.4 1.3
Long-standing illness, disability or infirmity 1.8 2.7 8.2 -1.4 -0.4 0.2 -2.9 1.8
Ever had bowel cancer screening 0.8 0.9 2.8 1.7 0.4 -0.3 -0.5 -1.1
Diabetes diagnosed by doctor 0.9 1.4 4.6 -1.5 0.2 0.4 -0.2 2.1
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 4.6 1.0 -0.3 0.1 2.1 -0.8
Friendships satisfaction 0.6 0.7 2.5 0.5 -1.6 0.7 0.3 0.3
Qualifications: nursing, teaching 0.6 0.9 3.4 0.2 -1.9 0.8 -0.4 0.3
Commuting to job workplace: Walk 2.6 2.8 5.7 -2.4 1.1 -1.2 1.2 2.0
Eye problems/disorders: Cataract 0.2 0.2 0.7 -0.9 -0.4 0.2 -0.3 0.1
Mouth/teeth dental problems: Mouth ulcers 1.1 1.8 2.7 -1.6 1.3 -0.7 -1.6 1.3
Medication for cholesterol 0.8 1.2 3.7 0.9 1.0 -0.7 1.9 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 2.8 -1.0 0.8 -1.7 -0.0 0.9
Back pain experienced in last month 0.7 1.0 5.0 -0.1 -0.0 2.2 -0.2 0.3
Mineral and other dietary supplements 0.4 0.5 2.1 0.0 0.2 0.7 1.4 -0.1
Breast cancer (self-reported) 0.4 0.5 1.5 0.1 -0.5 -0.1 -1.2 -0.9
Asthma (self-reported) 0.1 0.2 0.4 0.6 0.7 -0.2 0.4 -0.1
Osteoporosis (self-reported) 1.3 1.6 3.1 1.8 0.1 -0.4 -1.4 -1.7
Osteoarthritis (self-reported) 1.3 1.7 3.3 -1.8 0.6 0.1 -1.8 1.2
Medication: Aspirin 2.0 2.6 4.9 -2.2 0.6 -1.2 -1.2 2.2
Medication: Gliclazide 1.6 1.9 5.0 -1.9 -0.4 0.6 -0.4 2.2
Illnesses of father: None of the above (group 1) 0.3 0.4 0.7 -0.6 0.2 -0.6 -0.7 0.8
Smoking status: Current 2.1 3.3 5.7 -1.7 2.4 -1.4 -0.4 2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.7 3.6 10.5 1.0 -3.2 1.0 1.6 -1.6
Whole body water mass 0.3 2.0 5.5 -2.4 1.4 0.2 -0.7 1.4
Leg predicted mass (right) 0.4 2.2 5.5 -2.4 1.4 -0.1 -1.0 1.6
Arm fat mass (left) 2.2 9.1 15.3 -3.9 2.9 -1.6 -3.6 2.7
Number of self-reported non-cancer illnesses 1.3 2.2 8.9 -0.3 -1.4 0.0 -3.0 0.1
Average weekly champagne plus white wine intake 1.7 2.3 5.2 1.6 -2.3 -0.6 0.6 -1.7
Miserableness 2.9 5.1 11.8 -3.4 1.1 -0.9 -2.2 2.6
Guilty feelings 1.6 2.4 10.0 -0.9 0.7 -0.2 -3.2 0.7
Wears glasses or contact lenses 1.6 1.9 3.7 -1.4 -1.0 1.9 -0.9 1.4
Ever taken oral contraceptive pill 0.4 0.5 0.9 -0.9 -0.3 0.6 0.4 0.9
Hearing aid user 0.7 0.8 1.5 -1.0 1.2 -0.8 -0.3 0.7
Mother’s age at death 1.6 1.9 4.4 2.1 -0.9 2.1 0.2 -0.5
Financial situation satisfaction 1.1 1.4 2.9 -0.5 -1.7 1.7 -0.7 0.7
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.2 -0.3 -0.4 -0.5 0.5 1.1
Commuting to job workplace: Public transport 0.2 0.2 0.5 0.4 0.6 -0.7 0.2 -0.1
Eye problems/disorders: Glaucoma 0.4 0.5 1.9 0.7 0.1 -0.4 -1.4 -0.3
Medication: Blood pressure 0.5 1.0 2.4 -0.9 -1.2 0.8 -1.5 -0.1
Pain type(s) experienced in last month: Hip pain 1.8 2.3 4.4 -2.0 0.6 -0.5 -1.4 2.1
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.1 -0.4 -0.2 0.1 -1.0 1.0
High cholesterol (Self-reported) 0.4 0.7 2.1 0.5 -1.5 -0.3 -0.9 0.4
Medication: Bendroflumethiazide 0.4 0.6 1.0 0.2 -0.9 1.0 -0.8 -0.6
Medication: Paracetamol 0.4 0.5 0.9 -0.8 1.0 0.1 -0.7 0.8
Medication: Lisinopril 0.3 0.4 1.3 0.1 -0.8 1.2 -0.0 0.4
Medication: Atorvastatin 1.0 1.3 4.1 -0.7 -0.4 -1.3 -0.1 2.0
Illnesses of father: High blood pressure 0.3 0.4 0.7 0.7 -0.8 0.4 0.6 0.3
Alcohol drinker status: Never 1.3 1.6 3.0 -1.5 1.1 0.1 -1.7 1.3
Ever smoked 2.3 4.1 7.7 -2.6 2.8 -1.2 -1.0 1.9
Basal metabolic rate 0.5 2.9 7.4 -2.7 1.6 -0.1 -1.2 1.7
Leg fat percentage (left) 2.0 7.3 11.6 -3.2 2.3 -1.6 -3.4 2.6
Arm fat-free mass (left) 0.4 2.0 5.4 -2.3 1.5 0.2 -0.7 1.3
Number of operations (self-reported) 0.8 1.1 2.2 -0.9 0.8 -0.6 -1.5 1.3
Average weekly beer plus cider intake 0.2 0.3 0.7 0.5 -0.3 0.6 0.9 -0.2
Irritability 2.4 4.1 6.1 -2.5 1.2 -1.8 -1.9 2.5
Risk taking 0.2 0.4 0.9 -0.0 0.9 0.5 0.1 0.8
Ever had prostate specific antigen (PSA) test 0.3 0.4 0.8 -0.5 -0.7 0.9 -0.1 0.7
Fractured/broken bones in last 5 years 4.4 5.7 11.4 3.4 -2.7 1.7 -0.4 -2.6
Age started oral contraceptive pill 2.8 3.5 7.8 1.5 -2.8 1.5 2.2 -0.3
Diastolic blood pressure, automated reading 2.6 8.1 19.2 2.5 -4.4 1.2 -1.2 -3.5
Ever depressed for a whole week 0.4 0.5 0.9 0.3 0.5 -1.0 -0.9 0.4
Unable to work because of sickness or disability 2.6 3.4 7.7 -1.6 1.6 -0.6 -2.8 1.9
Commuting to job workplace: Cycle 0.3 0.3 0.8 0.1 0.4 -0.9 -0.8 0.3
Myopia 0.6 0.9 3.0 -0.9 -0.3 -0.5 -0.7 1.7
Vascular/heart problems diagnosed by doctor 0.7 1.9 6.7 0.7 1.3 0.3 2.6 -0.6
Cholesterol lowering medication 0.7 1.0 2.2 -0.3 -1.4 0.6 -1.5 -0.4
Medication: Omeprazole (e.g. Zanprol) 2.3 2.8 6.1 -1.7 1.0 1.1 -1.7 2.5
Pain experienced in last month 1.1 1.8 3.4 1.5 -1.5 -1.9 0.3 -1.0
Supplements: Calcium 0.7 0.8 2.2 0.6 -1.2 -0.2 -1.5 -0.1
Basal cell carcinoma (self-reported) 0.5 0.6 2.6 0.4 1.6 0.4 0.5 0.1
Heart attack/myocardial infarction (self-reported) 1.1 1.4 3.3 -0.7 -1.8 0.4 -1.8 0.2
Deep venous thrombosis (DVT) (self-reported) 1.7 2.2 5.6 0.1 -2.4 0.6 -2.1 -0.6
Heart disease (siblings) 0.7 0.9 2.3 0.8 0.9 0.4 -1.5 -0.7
Alcohol drinker status: Previous 0.6 0.7 1.9 0.4 1.4 -0.8 0.5 0.6
Pack years of smoking 1.0 1.5 2.0 -1.0 1.4 1.3 -1.2 1.3
Impedance of whole body 0.7 3.7 6.8 2.6 -2.5 0.5 -0.1 -2.3
Leg fat mass (left) 2.1 8.0 12.7 -3.6 2.7 -1.6 -3.3 2.6
Arm predicted mass (left) 0.4 2.1 6.2 -2.5 1.4 0.0 -0.8 1.4