Hub : Traits :

Number of incorrect matches in round

160 significantly associated models · 41 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 201158976 202552839 1 1 2.1e-07 5.2e-07 1.0e+00 100 SHISA4
2 5 92224862 94144549 2 1 5.1e-09 6.5e-09 6.5e-03 78 NR2F1
3 7 5925156 7318723 1 1 2.8e-07 1.5e-04 3.4e-03 40 ZDHHC4
4 8 135770324 137364619 1 1 4.8e-08 1.7e-06 5.3e-01 98 KHDRBS3
5 10 102853189 104242886 1 1 6.9e-08 8.3e-10 4.4e-05 56 NPM3
6 12 122062722 123604492 1 1 3.3e-07 3.3e-06 2.4e-01 94 CLIP1
7 15 90718541 92120170 1 1 7.6e-08 7.2e-08 1.0e+00 100 FURIN
8 16 28825605 31833122 33 2 1.7e-12 1.1e-10 5.0e-02 91 KAT8 TBX6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in mother) 3.11 1 0 0.0 0 1 KAT8
Alzheimer’s Disease (including proxy) 2.89 1 0 0.0 0 1 KAT8
Major Depression (MDD) 2.05 1 0 0.0 0 1 FURIN
Verbal and Numeric Reasoning (VNR) 3.39 2 1 3.0 0 1 KHDRBS3 NPM3
Breast Cancer 2.11 1 0 0.0 0 1 FURIN
Schizophrenia 3.52 1 1 3.0 0 1 FURIN
Triglycerides 2.56 1 0 0.0 0 1 KAT8
Blood Eosinophil Count 1.76 2 1 3.0 0 1 KAT8 TBX6
Blood Platelet Count 0.38 1 1 3.0 0 1 TBX6
Blood Red Count 3.36 3 3 9.1 0 1 KAT8 KHDRBS3 TBX6
Blood White Count 1.11 2 1 3.0 0 1 FURIN NPM3
Heel T-Score 1.04 3 1 3.0 0 1 KAT8 SHISA4 TBX6
BMI 4.02 2 2 6.1 0 1 KAT8 TBX6
Height 1.43 2 2 6.1 0 1 FURIN TBX6
Systolic Blood Pressure 4.00 2 1 3.0 0 1 FURIN NPM3
Smoking Status 2.02 1 0 0.0 0 1 KAT8
Cardiovascular Disease 3.84 2 2 6.1 0 1 FURIN KAT8
Respiratory disease 1.47 1 0 0.0 0 1 FURIN
Lung FEV1/FVC ratio 0.72 1 0 0.0 0 1 TBX6
Lung FVC 1.96 3 1 3.0 0 1 CLIP1 KAT8 KHDRBS3
Neuroticism 3.42 2 0 0.0 0 1 FURIN KHDRBS3
Hair Pigment 0.15 1 0 0.0 0 1 FURIN
Hand grip strength (left) 4.13 2 2 6.1 0 1 NPM3 TBX6
Sensitivity / hurt feelings 4.91 3 1 3.0 0 1 CLIP1 FURIN KHDRBS3
Hearing difficulty/problems: Yes 2.40 1 0 0.0 0 1 NR2F1
Systolic blood pressure, automated reading 2.93 1 1 3.0 0 1 FURIN
Angina 3.31 1 1 3.0 0 1 FURIN
Diabetes (father) 1.79 1 0 0.0 0 1 TBX6
Impedance of leg (right) 3.70 3 3 9.1 0 1 FURIN KAT8 TBX6
Leg fat-free mass (left) 5.08 3 2 6.1 0 1 FURIN KAT8 TBX6
Trunk fat percentage 2.53 2 1 3.0 0 1 KAT8 KHDRBS3
Hand grip strength (right) 2.99 2 0 0.0 0 1 NPM3 TBX6
Age when periods started (menarche) 1.76 1 0 0.0 0 1 TBX6
High blood pressure 3.97 2 2 6.1 0 1 FURIN KAT8
Medication: Atenolol 2.22 1 0 0.0 0 1 FURIN
Sitting height 0.61 2 0 0.0 0 1 NR2F1 TBX6
High blood pressure (mother) 3.36 1 1 3.0 0 1 FURIN
Body mass index (BMI) 4.48 2 2 6.1 0 1 KAT8 TBX6
Impedance of leg (left) 3.46 3 3 9.1 0 1 FURIN KAT8 TBX6
Leg predicted mass (left) 5.07 3 2 6.1 0 1 FURIN KAT8 TBX6
Trunk fat mass 3.61 2 2 6.1 0 1 KAT8 TBX6
Waist circumference 5.39 2 2 6.1 0 1 KAT8 TBX6
Nervous feelings 3.31 2 0 0.0 0 1 KAT8 TBX6
Forced vital capacity (FVC) 2.87 3 2 6.1 0 1 KAT8 KHDRBS3 TBX6
Qualifications: None of the above 2.13 1 1 3.0 0 1 NPM3
Financial difficulties in last 2 years 2.21 1 0 0.0 0 1 KAT8
Heart attack 2.25 1 0 0.0 0 1 FURIN
Allergy 1.15 1 0 0.0 0 1 FURIN
Fluid intelligence score 2.11 1 1 3.0 0 1 NPM3
Illnesses of siblings 3.42 1 1 3.0 0 1 KAT8
Neuroticism score 2.40 1 0 0.0 0 1 KHDRBS3
Weight 5.49 2 2 6.1 0 1 KAT8 TBX6
Impedance of arm (right) 2.54 2 2 6.1 0 1 KAT8 TBX6
Arm fat percentage (right) 3.33 2 2 6.1 0 1 KAT8 TBX6
Trunk fat-free mass 4.64 2 2 6.1 0 1 KAT8 TBX6
Hip circumference 5.48 2 2 6.1 0 1 KAT8 TBX6
Number of live births 3.28 1 0 0.0 0 1 TBX6
Forced expiratory volume in 1-second (FEV1) 2.53 3 0 0.0 0 1 KAT8 KHDRBS3 TBX6
Pulse rate 1.72 1 0 0.0 0 1 SHISA4
Qualifications: A levels/AS levels or equivalent 1.88 1 0 0.0 0 1 NPM3
Forced expiratory volume in 1-second (FEV1), Best measure 2.38 2 1 3.0 0 1 KAT8 KHDRBS3
Impedance of arm (left) 2.70 2 2 6.1 0 1 KAT8 TBX6
Arm fat mass (right) 4.79 2 2 6.1 0 1 KAT8 TBX6
Trunk predicted mass 4.69 2 2 6.1 0 1 KAT8 TBX6
Standing height 1.24 1 1 3.0 0 1 TBX6
Tense / 'highly strung' 4.22 3 0 0.0 0 1 FURIN KAT8 TBX6
Birth weight of first child 2.76 1 1 3.0 0 1 FURIN
Medication for cholesterol, blood pressure or diabetes 2.25 1 0 0.0 0 1 FURIN
Birth weight 2.19 1 1 3.0 0 1 FURIN
High blood pressure (siblings) 4.72 1 1 3.0 0 1 KAT8
Forced vital capacity (FVC), Best measure 2.67 3 2 6.1 0 1 KAT8 KHDRBS3 TBX6
Body fat percentage 2.72 1 1 3.0 0 1 KAT8
Leg fat percentage (right) 2.29 1 1 3.0 0 1 KAT8
Arm fat-free mass (right) 4.82 2 2 6.1 0 1 KAT8 TBX6
Comparative body size at age 10 1.46 1 0 0.0 0 1 KAT8
Qualifications: College or University degree 2.75 2 1 3.0 0 1 KAT8 NPM3
Medication: Blood pressure 2.44 1 0 0.0 0 1 FURIN
Angina (self-reported) 3.18 1 1 3.0 0 1 FURIN
Whole body fat mass 3.97 2 2 6.1 0 1 KAT8 TBX6
Leg fat mass (right) 3.95 2 2 6.1 0 1 KAT8 TBX6
Arm predicted mass (right) 4.99 2 2 6.1 0 1 KAT8 TBX6
Pulse rate, automated reading 1.70 1 1 3.0 0 1 SHISA4
Alcohol intake frequency. 3.03 2 1 3.0 0 1 KAT8 TBX6
Comparative height size at age 10 2.06 2 1 3.0 0 1 FURIN TBX6
Suffer from 'nerves' 1.92 1 0 0.0 0 1 TBX6
Overall health rating 2.16 1 1 3.0 0 1 KAT8
Medication: Aspirin 2.56 1 0 0.0 0 1 FURIN
Knee pain experienced in last month 1.84 1 0 0.0 0 1 KAT8
Hypertension (Self-reported) 3.96 2 2 6.1 0 1 FURIN KAT8
Forced expiratory volume in 1-second (FEV1), predicted 1.19 1 0 0.0 0 1 TBX6
Whole body fat-free mass 5.03 3 2 6.1 0 1 FURIN KAT8 TBX6
Leg fat-free mass (right) 5.21 3 2 6.1 0 1 FURIN KAT8 TBX6
Arm fat percentage (left) 3.27 2 2 6.1 0 1 KAT8 TBX6
Handedness (chirality/laterality): Left-handed 2.45 1 0 0.0 0 1 FURIN
Medication for cholesterol 2.39 1 0 0.0 0 1 KAT8
Medication: Aspirin 2.66 1 0 0.0 0 1 FURIN
Illnesses of father: None of the above (group 1) 3.24 1 0 0.0 0 1 FURIN
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.80 2 1 3.0 0 1 KAT8 KHDRBS3
Whole body water mass 5.05 3 2 6.1 0 1 FURIN KAT8 TBX6
Leg predicted mass (right) 5.22 3 2 6.1 0 1 FURIN KAT8 TBX6
Arm fat mass (left) 4.81 2 2 6.1 0 1 KAT8 TBX6
Guilty feelings 1.94 1 0 0.0 0 1 KHDRBS3
Medication: Blood pressure 4.03 2 1 3.0 0 1 FURIN KAT8
High cholesterol (Self-reported) 2.04 1 0 0.0 0 1 KAT8
Medication: Bendroflumethiazide 3.67 2 0 0.0 0 1 FURIN TBX6
Basal metabolic rate 5.34 3 2 6.1 0 1 FURIN KAT8 TBX6
Leg fat percentage (left) 2.46 1 1 3.0 0 1 KAT8
Arm fat-free mass (left) 5.05 2 2 6.1 0 1 KAT8 TBX6
Number of operations (self-reported) 2.34 1 0 0.0 0 1 FURIN
Fractured/broken bones in last 5 years 1.71 1 0 0.0 0 1 KAT8
Diastolic blood pressure, automated reading 2.32 2 2 6.1 0 1 FURIN KAT8
Vascular/heart problems diagnosed by doctor 4.48 2 2 6.1 0 1 FURIN KAT8
Cholesterol lowering medication 2.54 1 0 0.0 0 1 KAT8
Heart attack/myocardial infarction (self-reported) 2.13 1 0 0.0 0 1 FURIN
Impedance of whole body 3.37 2 2 6.1 0 1 KAT8 TBX6
Leg fat mass (left) 3.97 2 2 6.1 0 1 KAT8 TBX6
Arm predicted mass (left) 5.13 2 2 6.1 0 1 KAT8 TBX6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 5 0.1432 1.66
GTEx Adipose Visceral Omentum 6 0.2947 1.73
GTEx Adrenal Gland 3 0.2059 1.72
GTEx Artery Aorta 7 0.2351 1.73
GTEx Artery Coronary 2 0.1691 1.71
GTEx Artery Tibial 7 0.1861 1.65
GTEx Brain Caudate basal ganglia 1 0.1087 1.67
GTEx Brain Cerebellar Hemisphere 2 0.1343 1.70
GTEx Brain Cerebellum 1 0.0505 1.63
GTEx Brain Cortex 1 0.0966 1.62
GTEx Brain Frontal Cortex BA9 1 0.1082 1.80
GTEx Brain Hippocampus 0 0.0000 1.87
GTEx Brain Hypothalamus 0 0.0000 1.66
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.70
GTEx Brain Putamen basal ganglia 0 0.0000 1.53
GTEx Breast Mammary Tissue 2 0.1013 1.70
GTEx Breast Mammary Tissue (Male) 1 0.0838 1.69
GTEx Breast Mammary Tissue (Female) 2 0.1217 1.63
GTEx Cells EBV-transformed lymphocytes 2 0.1405 1.75
GTEx Cells Transformed fibroblasts 6 0.1429 1.69
GTEx Colon Sigmoid 0 0.0000 1.63
GTEx Colon Transverse 3 0.1453 1.73
GTEx Esophagus Gastroesophageal Junction 1 0.0692 1.70
GTEx Esophagus Mucosa 4 0.1205 1.72
GTEx Esophagus Muscularis 4 0.1238 1.69
GTEx Heart Atrial Appendage 3 0.1900 1.70
GTEx Heart Left Ventricle 4 0.2614 1.75
GTEx Liver 2 0.2789 1.76
GTEx Lung 5 0.1740 1.73
GTEx Muscle Skeletal 2 0.0692 1.70
GTEx Nerve Tibial 4 0.0926 1.72
GTEx Ovary 6 0.6608 2.00
GTEx Pancreas 2 0.1225 1.72
GTEx Pituitary 3 0.2691 1.86
GTEx Prostate 4 0.4790 1.83
GTEx Skin Not Sun Exposed Suprapubic 2 0.0813 1.70
GTEx Skin Sun Exposed Lower leg 4 0.1099 1.71
GTEx Small Intestine Terminal Ileum 2 0.4338 1.90
GTEx Spleen 2 0.1417 1.72
GTEx Stomach 3 0.2063 1.75
GTEx Testis 4 0.1268 1.70
GTEx Thyroid 6 0.1500 1.69
GTEx Uterus 2 0.3527 1.84
GTEx Vagina 1 0.1575 1.69
GTEx Whole Blood 3 0.1505 1.70
METSIM Adipose 2 0.0434 1.61
NTR Blood 1 0.0416 1.59
ROSMAP Brain Pre-frontal Cortex 13 0.2961 1.74
YFS Blood 4 0.0866 1.59
CommonMind Brain Pre-frontal Cortex 6 0.1116 1.64
TCGA Breast Tumor 0 0.0000 1.65
TCGA Breast Normal 2 0.0475 1.60
TCGA Ovarian Tumor 0 0.0000 1.59
TCGA Prostate Tumor 7 0.2024 1.62