Hub : Traits :

Mouth/teeth dental problems

19 significantly associated models · 11 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 154401972 155887772 4 1 4.4e-09 1.4e-07 0.0962 90 GBAP1
2 3 45262393 47096523 3 2 3.8e-09 1.5e-09 0.0058 79 CCR2 FYCO1
3 14 103161201 104866687 3 1 1.1e-07 4.3e-06 0.6800 99 KLC1
4 22 45736153 47135205 1 1 1.8e-07 2.1e-07 0.4150 98 LINC00899

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 2.58 1 0 0.0 0.00 1.00 GBAP1
Irritable Bowel Disease (IBD) 3.68 1 1 3.0 0.00 1.00 GBAP1
Ulcerative Colitis (UC) 4.58 2 0 0.0 0.00 1.00 FYCO1 GBAP1
Breast Cancer 2.85 1 0 0.0 0.00 1.00 GBAP1
Prostate Cancer 2.79 1 0 0.0 0.00 1.00 KLC1
Crohns Disease (2012) 2.05 1 0 0.0 0.00 1.00 GBAP1
Schizophrenia 3.79 1 1 3.0 0.00 1.00 KLC1
Blood Eosinophil Count 0.88 1 0 0.0 0.00 1.00 KLC1
Blood Platelet Count 0.99 1 1 3.0 0.00 1.00 GBAP1
Blood Red Count 2.08 2 1 3.0 0.00 1.00 GBAP1 KLC1
Blood White Count 1.98 2 1 3.0 0.00 1.00 CCR2 KLC1
Heel T-Score 6.19 4 4 12.1 0.68 0.32 FYCO1 GBAP1 KLC1 LINC00899
BMI 2.56 1 1 3.0 0.00 1.00 KLC1
Height 1.27 3 1 3.0 0.00 1.00 CCR2 GBAP1 KLC1
Waist Hip Ratio (WHR) 0.97 1 0 0.0 0.00 1.00 GBAP1
Smoking Status 5.31 2 1 3.0 0.00 1.00 KLC1 LINC00899
Cardiovascular Disease 2.74 1 1 3.0 0.00 1.00 KLC1
Hypothyroidism (self reported) 1.21 1 0 0.0 0.00 1.00 CCR2
Lung FEV1/FVC ratio 0.52 1 0 0.0 0.00 1.00 KLC1
Lung FVC 1.17 1 0 0.0 0.00 1.00 GBAP1
Hair Pigment 0.75 2 2 6.1 0.00 1.00 GBAP1 KLC1
Frequency of depressed mood in last 2 weeks 3.56 1 0 0.0 0.00 1.00 GBAP1
Hearing difficulty/problems: Yes 2.34 1 0 0.0 0.00 1.00 KLC1
Other serious medical condition/disability diagnosed by doctor 3.08 1 0 0.0 0.00 1.00 KLC1
Pack years adult smoking proportion 3.94 1 0 0.0 0.00 1.00 KLC1
Impedance of leg (right) 3.92 4 1 3.0 0.63 0.37 CCR2 FYCO1 GBAP1 KLC1
Leg fat-free mass (left) 1.87 3 0 0.0 0.00 1.00 CCR2 FYCO1 GBAP1
Trunk fat percentage 1.06 1 0 0.0 0.00 1.00 KLC1
Current tobacco smoking 4.18 2 0 0.0 0.00 1.00 KLC1 LINC00899
Maternal smoking around birth 4.35 1 1 3.0 0.00 1.00 KLC1
Frequency of unenthusiasm / disinterest in last 2 weeks 3.21 1 0 0.0 0.00 1.00 LINC00899
Heel bone mineral density (BMD) T-score, automated (left) 2.87 1 0 0.0 0.00 1.00 KLC1
High blood pressure 1.31 1 0 0.0 0.00 1.00 KLC1
Sitting height 1.22 2 0 0.0 0.00 1.00 CCR2 FYCO1
Body mass index (BMI) 2.41 1 1 3.0 0.00 1.00 KLC1
Impedance of leg (left) 3.21 4 1 3.0 0.61 0.39 CCR2 FYCO1 GBAP1 KLC1
Leg predicted mass (left) 1.80 3 0 0.0 0.00 1.00 CCR2 FYCO1 GBAP1
Trunk fat mass 1.09 1 0 0.0 0.00 1.00 KLC1
Waist circumference 1.38 1 0 0.0 0.00 1.00 KLC1
Past tobacco smoking 4.63 3 0 0.0 0.00 1.00 GBAP1 KLC1 LINC00899
Frequency of tenseness / restlessness in last 2 weeks 3.16 1 0 0.0 0.00 1.00 LINC00899
Hearing difficulty/problems with background noise 4.49 1 0 0.0 0.00 1.00 KLC1
Heel bone mineral density (BMD) T-score, automated (right) 1.55 1 0 0.0 0.00 1.00 KLC1
Financial difficulties in last 2 years 4.49 1 1 3.0 0.00 1.00 KLC1
Weight 1.39 2 0 0.0 0.00 1.00 GBAP1 KLC1
Impedance of arm (right) 0.74 1 0 0.0 0.00 1.00 KLC1
Arm fat percentage (right) 2.57 1 1 3.0 0.00 1.00 KLC1
Trunk fat-free mass 0.92 1 0 0.0 0.00 1.00 CCR2
Hip circumference 1.60 1 0 0.0 0.00 1.00 KLC1
Frequency of tiredness / lethargy in last 2 weeks 3.98 2 0 0.0 0.00 1.00 KLC1 LINC00899
Mouth/teeth dental problems: Dentures 7.50 2 1 3.0 0.00 1.00 GBAP1 LINC00899
Impedance of arm (left) 1.02 1 0 0.0 0.00 1.00 KLC1
Arm fat mass (right) 2.37 2 1 3.0 0.00 1.00 GBAP1 KLC1
Trunk predicted mass 0.92 1 0 0.0 0.00 1.00 CCR2
Standing height 0.99 2 1 3.0 0.00 1.00 CCR2 KLC1
Tense / 'highly strung' 1.65 1 0 0.0 0.00 1.00 LINC00899
Seen doctor (GP) for nerves, anxiety, tension or depression 2.64 1 0 0.0 0.00 1.00 LINC00899
Mouth/teeth dental problems: Bleeding gums 3.04 1 0 0.0 0.00 1.00 KLC1
Medication: Paracetamol 2.43 1 0 0.0 0.00 1.00 KLC1
Medication for cholesterol, blood pressure or diabetes 2.13 1 0 0.0 0.00 1.00 GBAP1
Gout (self-reported) 3.48 1 0 0.0 0.00 1.00 GBAP1
Birth weight 2.75 1 0 0.0 0.00 1.00 LINC00899
High blood pressure (siblings) 1.70 1 0 0.0 0.00 1.00 KLC1
Body fat percentage 1.14 1 0 0.0 0.00 1.00 KLC1
Leg fat percentage (right) 0.84 1 0 0.0 0.00 1.00 KLC1
Wheeze or whistling in the chest in last year 3.07 1 0 0.0 0.00 1.00 LINC00899
Health satisfaction 2.03 1 0 0.0 0.00 1.00 KLC1
Emphysema/chronic bronchitis 4.60 2 0 0.0 0.00 1.00 KLC1 LINC00899
Medication: Omeprazole 3.98 1 0 0.0 0.00 1.00 FYCO1
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.34 1 0 0.0 0.00 1.00 GBAP1
Whole body fat mass 1.25 1 0 0.0 0.00 1.00 KLC1
Leg fat mass (right) 0.94 1 0 0.0 0.00 1.00 KLC1
Arm predicted mass (right) 0.69 1 0 0.0 0.00 1.00 CCR2
Pulse rate, automated reading 1.34 1 0 0.0 0.00 1.00 KLC1
Comparative height size at age 10 1.07 1 1 3.0 0.00 1.00 KLC1
Number of full sisters 2.43 1 0 0.0 0.00 1.00 LINC00899
Overall health rating 2.43 1 0 0.0 0.00 1.00 KLC1
Illness, injury, bereavement, stress in last 2 years 3.17 1 0 0.0 0.00 1.00 KLC1
Hypertension (Self-reported) 1.39 1 0 0.0 0.00 1.00 KLC1
Smoking status: Previous 3.15 1 0 0.0 0.00 1.00 GBAP1
Whole body fat-free mass 1.25 2 0 0.0 0.00 1.00 CCR2 FYCO1
Leg fat-free mass (right) 2.33 3 0 0.0 0.00 1.00 CCR2 FYCO1 GBAP1
Arm fat percentage (left) 2.21 1 1 3.0 0.00 1.00 KLC1
Long-standing illness, disability or infirmity 2.81 1 0 0.0 0.00 1.00 KLC1
Mouth/teeth dental problems: Mouth ulcers 30.34 2 2 6.1 0.00 1.00 CCR2 FYCO1
Back pain experienced in last month 3.72 1 0 0.0 0.00 1.00 FYCO1
Smoking status: Current 4.20 2 0 0.0 0.00 1.00 KLC1 LINC00899
Whole body water mass 1.37 2 0 0.0 0.00 1.00 CCR2 FYCO1
Leg predicted mass (right) 2.30 3 0 0.0 0.00 1.00 CCR2 FYCO1 GBAP1
Arm fat mass (left) 2.27 2 1 3.0 0.00 1.00 GBAP1 KLC1
Number of self-reported non-cancer illnesses 2.92 1 0 0.0 0.00 1.00 KLC1
Miserableness 1.53 1 0 0.0 0.00 1.00 GBAP1
Mother's age at death 2.49 1 0 0.0 0.00 1.00 KLC1
Supplements: Fish oil (including cod liver oil) 2.19 1 0 0.0 0.00 1.00 KLC1
High cholesterol (Self-reported) 2.43 1 0 0.0 0.00 1.00 GBAP1
Medication: Paracetamol 1.87 1 0 0.0 0.00 1.00 KLC1
Medication: Atorvastatin 2.49 1 0 0.0 0.00 1.00 GBAP1
Ever smoked 4.12 1 0 0.0 0.00 1.00 LINC00899
Basal metabolic rate 1.38 3 0 0.0 0.00 1.00 CCR2 FYCO1 GBAP1
Leg fat percentage (left) 0.93 1 0 0.0 0.00 1.00 KLC1
Arm fat-free mass (left) 0.96 1 0 0.0 0.00 1.00 CCR2
Risk taking 7.17 2 0 0.0 0.00 1.00 KLC1 LINC00899
Diastolic blood pressure, automated reading 1.53 1 0 0.0 0.00 1.00 KLC1
Ever depressed for a whole week 2.03 1 0 0.0 0.00 1.00 KLC1
Unable to work because of sickness or disability 2.14 1 0 0.0 0.00 1.00 KLC1
Vascular/heart problems diagnosed by doctor 1.77 1 0 0.0 0.00 1.00 KLC1
Medication: Omeprazole (e.g. Zanprol) 3.78 1 0 0.0 0.00 1.00 FYCO1
Alcohol drinker status: Previous 4.26 1 0 0.0 0.00 1.00 KLC1
Pack years of smoking 3.90 2 0 0.0 0.00 1.00 KLC1 LINC00899
Impedance of whole body 1.88 3 0 0.0 0.00 1.00 CCR2 FYCO1 KLC1
Leg fat mass (left) 1.18 1 0 0.0 0.00 1.00 KLC1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.56
GTEx Adipose Visceral Omentum 0 0.0000 1.58
GTEx Adrenal Gland 0 0.0000 1.53
GTEx Artery Aorta 0 0.0000 1.51
GTEx Artery Coronary 0 0.0000 1.62
GTEx Artery Tibial 2 0.0532 1.50
GTEx Brain Caudate basal ganglia 0 0.0000 1.55
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.65
GTEx Brain Cerebellum 2 0.1009 1.63
GTEx Brain Cortex 0 0.0000 1.62
GTEx Brain Frontal Cortex BA9 0 0.0000 1.63
GTEx Brain Hippocampus 0 0.0000 1.59
GTEx Brain Hypothalamus 0 0.0000 1.50
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.62
GTEx Brain Putamen basal ganglia 0 0.0000 1.49
GTEx Breast Mammary Tissue 1 0.0507 1.65
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.56
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.60
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.55
GTEx Cells Transformed fibroblasts 1 0.0238 1.55
GTEx Colon Sigmoid 0 0.0000 1.63
GTEx Colon Transverse 0 0.0000 1.66
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.62
GTEx Esophagus Mucosa 0 0.0000 1.62
GTEx Esophagus Muscularis 1 0.0309 1.59
GTEx Heart Atrial Appendage 0 0.0000 1.64
GTEx Heart Left Ventricle 0 0.0000 1.58
GTEx Liver 0 0.0000 1.44
GTEx Lung 0 0.0000 1.48
GTEx Muscle Skeletal 2 0.0692 1.64
GTEx Nerve Tibial 0 0.0000 1.54
GTEx Ovary 0 0.0000 1.63
GTEx Pancreas 0 0.0000 1.55
GTEx Pituitary 0 0.0000 1.56
GTEx Prostate 1 0.1198 1.70
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.57
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.52
GTEx Small Intestine Terminal Ileum 1 0.2169 1.76
GTEx Spleen 1 0.0709 1.67
GTEx Stomach 0 0.0000 1.58
GTEx Testis 0 0.0000 1.56
GTEx Thyroid 1 0.0250 1.56
GTEx Uterus 0 0.0000 1.53
GTEx Vagina 0 0.0000 1.43
GTEx Whole Blood 0 0.0000 1.65
METSIM Adipose 1 0.0217 1.45
NTR Blood 1 0.0416 1.55
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.49
YFS Blood 0 0.0000 1.51
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.45
TCGA Breast Tumor 0 0.0000 1.65
TCGA Breast Normal 0 0.0000 1.34
TCGA Ovarian Tumor 1 0.0342 1.51
TCGA Prostate Tumor 1 0.0289 1.51