Hub : Genes

DCLK3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1060	0.0370	5.7e-05	0.020	0.036	0.044	0.047	0.031	1.4e-03	2.8e-05	4.1e-06	1.9e-06	9.7e-05
2	TCGA	Breast Invasive Carcinoma	0.0498	0.0176	1.1e-05	0.045	0.020	0.028	NA	0.036	1.3e-09	3.8e-05	1.7e-06	NA	4.7e-08
3	TCGA	Colon Adenocarcinoma	0.1490	0.0500	1.6e-05	0.015	0.079	0.045	NA	0.040	4.1e-02	2.4e-05	1.2e-03	NA	2.2e-03
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0952	0.0284	3.2e-09	0.077	0.087	0.109	NA	0.107	5.4e-09	5.9e-10	3.4e-12	NA	5.1e-12
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0854	0.0338	1.9e-04	0.022	0.032	0.028	NA	0.029	1.4e-03	1.4e-04	3.6e-04	NA	2.7e-04
6	TCGA	Lung Squamous Cell Carcinoma	0.0864	0.0313	3.3e-05	0.044	0.047	0.057	NA	0.054	9.4e-06	4.6e-06	4.6e-07	NA	8.6e-07
7	TCGA	Pancreatic Adenocarcinoma	0.1690	0.0710	8.7e-04	0.100	0.065	0.050	NA	0.082	5.9e-05	1.1e-03	3.9e-03	NA	2.7e-04
8	TCGA	Rectum Adenocarcinoma	0.5170	0.1230	3.5e-05	0.123	0.170	0.168	NA	0.195	8.5e-04	8.8e-05	9.6e-05	NA	2.5e-05
9	TCGA	Stomach Adenocarcinoma	0.1130	0.0480	1.4e-03	0.006	0.049	0.052	NA	0.017	1.1e-01	1.7e-04	1.2e-04	NA	1.9e-02
10	TCGA	Thyroid Carcinoma	0.1150	0.0420	2.7e-05	0.081	0.068	0.084	NA	0.083	2.5e-08	3.4e-07	1.4e-08	NA	1.9e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	4.4	7.0	27.4	-5.2	1.8	1.1	1.6	2.6	2.4	1.9	2.4	2.7	2.5
Bipolar Disorder or Schizophrenia	1.6	3.9	21.2	-4.6	0.9	1.0	1.5	1.6	1.5	1.5	2.0	0.7	1.4
Depressed Affect (Nagel 2018)	0.2	0.3	1.1	-0.3	-0.0	0.2	-0.2	-0.9	-1.1	-0.5	-0.3	-0.8	-0.4
Depression (Nagel 2018)	0.2	0.3	1.0	-1.0	-0.5	-0.4	0.3	0.0	-0.9	0.1	0.4	-0.6	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.8	2.0	-1.0	-0.3	-0.0	0.8	1.4	0.6	0.9	0.9	1.4	0.2
Neuroticism (Nagel 2018)	0.3	0.8	2.7	-1.6	-0.2	-1.1	-0.4	-0.1	-1.1	-0.8	-0.3	-1.1	-0.6
Schizophrenia (2018)	0.3	0.6	2.8	-1.7	-0.3	0.3	0.6	-0.0	0.0	0.4	0.7	-1.4	-0.2
Schizophrenia vs Biploar Disorder	1.3	1.7	3.6	1.0	-1.9	-1.4	-0.9	-1.0	-1.7	-0.8	-1.0	-1.1	-1.8
Worry (Nagel 2018)	1.3	2.7	5.9	-1.3	-1.2	-2.3	-1.1	-1.1	-2.2	-1.3	-1.2	-2.4	-1.7
Alzheimer’s Disease (in mother)	1.3	1.5	2.9	-0.6	1.0	1.6	1.0	1.6	1.3	0.9	0.9	1.7	1.4
Alzheimer’s Disease (in father)	0.5	0.5	1.9	-1.4	0.5	-0.1	-1.0	-0.1	-0.1	-0.7	-1.0	0.7	0.4
Alzheimer’s Disease (including proxy)	0.5	0.8	1.9	-1.3	0.6	1.2	0.1	0.8	0.9	0.4	0.2	1.4	0.9
Crohns Disease (2017)	0.5	1.1	2.2	1.5	-1.1	-0.5	-0.7	-1.1	-0.2	-0.8	-1.4	-1.4	-1.2
Irritable Bowel Disease (IBD)	0.2	0.5	1.8	0.6	-0.4	0.3	-0.9	-0.5	0.0	-1.2	-1.4	-0.5	-0.5
Ulcerative Colitis (UC)	0.2	0.4	0.9	-0.8	0.5	0.9	-0.7	0.0	0.6	-0.9	-0.8	0.1	0.3
Major Depression (MDD)	0.4	0.5	1.9	0.4	-0.1	0.3	1.0	0.8	0.0	0.8	1.4	-0.1	-0.0
Reaction Time	0.4	0.7	2.3	-1.2	-0.8	0.5	-0.2	-1.0	-1.5	0.2	-0.1	0.8	-0.8
Verbal and Numeric Reasoning (VNR)	0.8	2.0	6.4	-0.8	-0.0	0.4	1.3	2.2	1.5	1.3	1.3	2.5	0.6
Breast Cancer	0.7	1.7	6.2	-2.5	-0.7	0.2	1.4	-1.0	-0.9	2.1	1.0	0.8	-0.3
Ovarian Cancer	3.0	3.9	6.0	-0.1	2.1	2.3	1.9	1.9	2.4	2.4	2.0	1.2	2.2
Prostate Cancer	1.2	1.7	2.8	0.9	-1.6	-1.6	-1.5	-0.4	0.1	-1.4	-1.1	-1.6	-1.7
Age at First Birth	0.7	1.1	4.1	-2.0	0.7	0.0	0.3	1.2	0.9	0.8	0.5	1.2	1.3
Bipolar Disorder (2011)	1.4	1.3	13.2	-3.6	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.6	1.5	0.8	0.7	0.8	0.9	1.2	0.7	0.4	1.2	0.3	0.6
Coronary Artery Disease (CAD)	0.7	0.8	3.0	0.9	0.0	-1.7	-0.8	-0.3	-1.0	-0.4	-0.9	0.5	-1.1
Crohns Disease (2012)	0.3	0.4	2.7	1.6	0.5	0.2	-0.1	0.4	0.6	-0.3	0.0	-0.7	0.5
Mean Putamen Volume	0.7	0.8	1.9	0.2	0.7	0.4	1.0	0.8	1.2	1.0	1.4	-0.6	1.0
Fasting Glucose	1.3	1.5	3.3	-0.5	0.8	1.5	1.8	1.3	1.6	1.1	1.5	0.7	0.7
HbA1C	0.8	0.9	4.0	-0.5	0.8	2.0	1.0	0.2	1.4	0.8	0.5	-0.2	0.5
HDL Cholesterol	0.3	0.6	2.2	-0.3	-1.0	-0.4	-0.3	-0.6	-0.5	-0.4	-0.4	-1.5	-1.0
LDL Cholesterol	0.3	0.5	2.4	-0.5	0.3	-0.2	0.0	-1.0	-0.9	-0.1	-0.0	-1.5	0.1
Lupus	0.2	0.3	1.7	0.0	-0.3	-0.4	-0.2	0.0	-1.3	-0.3	0.0	1.2	-0.0
Neuroticism (2016)	0.5	0.7	3.3	-1.8	0.3	0.2	0.9	0.8	0.7	0.8	1.1	0.1	0.2
Primary Biliary Cirrhosis	0.7	1.0	2.1	1.1	-0.5	-0.6	-1.3	-0.4	-0.8	-1.3	-1.4	-1.2	-1.0
Rheumatoid Arthritis	0.2	0.3	0.9	1.0	0.5	-0.1	-0.1	0.9	0.2	-0.2	0.0	0.8	0.6
Schizophrenia (2014)	0.5	1.0	6.2	-2.5	-0.2	-0.3	0.7	1.0	0.7	0.4	0.9	-0.8	-0.0
Triglycerides	0.3	0.4	1.9	1.1	1.4	0.0	-0.1	-0.4	-0.2	-0.2	0.2	-0.2	0.9
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.8	1.3	-0.9	-0.2	-0.5	-0.4	-0.9	0.3	-0.5	0.7	-0.2
Ulcerative Colitis	0.6	0.8	2.3	-0.5	1.4	1.5	0.2	0.8	1.2	-0.2	0.2	-0.0	1.2
Blood Eosinophil Count	0.2	1.2	3.5	-1.7	1.1	0.3	0.5	1.9	1.1	0.3	1.0	0.8	1.2
Blood Platelet Count	0.1	1.0	3.0	-1.3	0.7	1.0	0.3	1.7	1.6	-0.5	0.4	-0.6	0.4
Blood Red Count	0.1	0.5	3.3	1.8	0.7	-0.0	0.3	0.1	0.6	0.4	0.5	-0.0	0.8
Blood White Count	0.1	0.5	2.9	-1.7	-0.8	0.6	-0.2	0.1	-0.2	-0.3	-0.7	0.2	-0.9
Heel T-Score	0.1	0.8	1.8	0.4	-0.7	-1.3	-1.3	-0.3	-0.8	-0.9	-1.4	-0.3	-0.6
BMI	0.6	3.5	7.8	2.1	2.3	1.4	0.8	2.7	2.8	0.3	1.1	1.2	2.1
Height	0.3	4.9	17.1	4.1	-1.0	-2.1	-2.2	-2.1	-2.8	-1.5	-2.4	-0.2	-1.1
Waist Hip Ratio (WHR)	0.1	0.6	1.2	-0.4	-0.6	-0.9	-1.1	0.4	-1.1	-0.9	-0.6	0.7	-0.5
Systolic Blood Pressure	0.1	0.4	1.5	1.2	0.6	-0.4	-0.5	0.0	0.0	-0.7	-0.6	0.9	0.5
Smoking Status	0.4	0.9	2.6	-1.6	-0.5	0.1	0.8	-0.8	-1.2	0.7	1.2	-1.0	-0.5
Allergy or Eczema	0.5	1.3	2.7	-0.6	1.3	1.0	1.0	0.8	1.1	1.3	1.5	0.5	1.6
Cardiovascular Disease	0.1	0.2	0.9	-1.0	0.3	0.4	0.3	0.5	0.3	0.0	0.1	0.4	0.1
Hypothyroidism (self reported)	0.6	1.3	8.7	3.0	-0.5	-0.3	-0.8	-0.8	-0.4	-0.9	-1.1	-0.2	-0.6
Respiratory disease	0.8	1.7	4.4	-0.8	2.1	0.8	0.7	1.8	1.2	0.3	1.1	0.8	2.0
Type 2 Diabetes (T2D) (2018)	0.5	1.0	3.9	1.0	-0.0	1.2	0.9	0.7	1.0	0.9	0.2	2.0	0.1
Lung FEV1/FVC ratio	0.3	1.6	8.6	2.9	-0.9	0.2	-1.4	-0.8	0.2	-1.2	-1.3	-0.5	-0.8
Lung FVC	0.2	0.8	5.1	-2.3	-0.5	-0.3	0.9	0.1	-0.1	0.5	0.7	-0.7	-0.5
Neuroticism	0.3	0.6	2.3	-1.5	0.0	0.0	1.2	0.2	-0.4	0.9	1.0	-0.7	-0.1
Chronotype (morning person)	1.1	2.6	9.3	3.0	-1.6	-1.5	-1.0	-1.2	-1.2	-1.2	-1.0	-1.5	-1.9
Hair Pigment	0.1	3.8	9.0	-0.9	3.0	1.0	1.8	2.4	2.5	1.1	1.8	1.1	2.5
Tanning	0.1	0.9	3.0	1.6	-0.5	0.2	-1.3	-0.4	-0.3	-1.7	-1.1	-0.5	-0.4
Hand grip strength (left)	0.2	0.5	1.0	0.9	0.9	0.2	0.1	0.5	1.0	-0.4	0.6	-0.7	0.8
Number of treatments/medications taken	0.3	0.6	1.7	0.7	0.5	1.2	1.2	0.4	0.5	1.3	0.6	0.1	0.2
Average weekly spirits intake	0.7	0.9	4.1	-0.2	0.5	2.0	0.4	0.4	0.8	0.1	0.1	1.8	0.6
Sensitivity / hurt feelings	1.0	1.7	4.3	-2.1	1.1	0.1	1.1	1.4	0.3	1.3	1.2	1.9	1.3
Frequency of depressed mood in last 2 weeks	0.4	0.5	3.7	-1.9	-0.2	0.5	0.4	-0.3	-0.9	0.3	0.5	-0.0	-0.2
Hearing difficulty/problems: Yes	0.1	0.2	1.4	1.2	0.1	-0.1	-0.4	-0.2	-0.0	-0.3	-0.4	0.4	-0.0
Relative age of first facial hair	1.3	2.6	6.1	0.5	-2.5	-0.8	-1.4	-1.7	-2.4	-1.0	-1.6	-0.1	-2.2
Other serious medical condition/disability diagnosed by doctor	2.7	3.4	5.0	-0.5	1.7	1.9	2.1	1.8	1.8	2.2	1.9	2.1	1.9
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.8	0.5	0.4	1.3	0.7	-0.7	0.1	0.8	0.5	-1.0	0.3
Ever had hysterectomy (womb removed)	1.0	1.2	2.7	0.0	1.0	1.3	1.6	-0.0	0.7	1.6	1.6	-0.5	0.9
Systolic blood pressure, automated reading	0.2	0.7	1.5	1.1	1.0	1.2	0.1	0.5	0.6	-0.3	-0.1	1.2	0.8
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.5	-1.2	0.3	-0.8	0.3	1.2	0.1	0.3	0.0	0.8	0.2
Angina	0.8	1.0	2.8	-0.9	-0.0	-0.8	1.6	0.1	-0.4	1.7	1.5	-0.7	-0.0
Medication for hormone replacement therapy	0.5	0.6	1.5	0.5	1.2	0.9	0.5	0.4	1.1	-0.0	0.2	-1.0	0.7
Vitamin and mineral supplements	0.5	0.7	1.8	-1.4	0.7	0.1	-0.1	1.3	1.3	-0.6	0.1	0.7	0.7
Supplements: Zinc	0.3	0.3	2.0	0.1	-0.1	-0.0	-0.4	-0.7	-0.3	0.2	-0.3	1.4	0.2
Medication: Co-codamol	0.2	0.3	1.6	0.5	0.1	0.6	-0.1	0.1	-0.1	-0.4	-0.3	-1.3	-0.2
Medication: Metformin	0.3	0.5	1.1	0.7	-0.9	0.7	-0.5	-0.6	-0.6	-0.1	-1.0	0.6	-0.8
Diabetes (father)	1.0	1.3	3.0	0.0	1.3	1.7	1.3	0.6	0.9	1.2	1.5	0.1	1.2
Diabetes (mother)	1.6	2.0	4.6	1.7	-0.4	-1.1	-1.8	-0.0	0.4	-2.1	-1.6	-2.1	-0.9
Severe depression (siblings)	0.6	0.6	2.2	-0.8	0.5	0.8	0.2	0.7	1.5	-0.1	0.4	-1.3	0.3
Pack years adult smoking proportion	0.2	0.2	0.8	0.8	0.4	-0.5	-0.4	0.3	-0.2	-0.9	-0.1	-0.5	0.0
Impedance of leg (right)	0.5	2.3	8.4	-0.3	-1.7	-0.3	-1.1	-2.9	-2.3	-0.4	-1.4	-0.4	-1.4
Leg fat-free mass (left)	0.4	2.2	4.8	2.2	1.8	0.5	0.2	2.0	1.8	-0.2	0.7	1.7	1.7
Trunk fat percentage	0.3	1.1	7.3	2.7	0.2	0.9	-0.6	0.4	1.0	-0.8	-0.5	0.5	0.2
Hand grip strength (right)	0.1	0.4	1.9	1.4	0.8	0.1	-0.0	-0.2	0.5	-0.1	0.4	-0.3	0.8
Townsend deprivation index at recruitment	0.4	0.5	2.5	-1.6	0.0	-0.6	0.6	0.6	0.3	0.4	0.9	-0.6	-0.2
Current tobacco smoking	0.2	0.3	1.6	-0.7	0.3	-0.1	0.6	0.1	-0.4	0.1	1.3	-0.6	0.1
Average weekly fortified wine intake	0.4	0.5	2.0	1.4	0.1	-0.3	-1.0	0.3	0.4	-0.9	-0.7	-0.2	0.1
Maternal smoking around birth	0.7	1.1	6.0	1.2	1.3	0.7	-0.1	-0.5	-0.2	-0.7	0.0	-2.4	0.4
Fed-up feelings	0.3	0.5	1.6	0.7	0.8	0.5	-0.3	-1.2	-0.6	0.1	-0.3	-1.3	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.6	-0.4	0.6	0.5	0.9	0.1	0.1	0.7	1.1	-1.2	0.4
Relative age voice broke	1.1	1.7	3.8	-0.3	-1.7	-0.2	-1.1	-1.7	-1.9	-0.8	-1.5	-0.6	-1.6
Taking other prescription medications	0.2	0.3	0.6	0.6	0.8	0.6	0.0	0.8	0.5	0.4	-0.2	0.8	0.7
Age when periods started (menarche)	0.3	0.8	1.8	1.2	-1.3	-1.1	-0.3	-0.8	-0.9	0.1	-0.6	-0.5	-1.2
Bilateral oophorectomy (both ovaries removed)	4.5	5.2	10.5	0.2	2.5	2.8	3.2	1.0	2.4	2.9	2.7	-0.8	2.1
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	6.0	-1.0	-1.8	-0.7	-2.2	-1.1	-1.4	-2.3	-2.5	-1.2	-1.9
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.9	0.5	0.1	0.4	0.8	1.1	-0.1	0.9	0.7	1.4	0.3
Qualifications: CSEs or equivalent	0.4	0.6	2.7	-0.6	1.1	1.7	-0.1	-0.6	0.4	0.3	0.0	0.3	1.0
Serious illness, injury or assault to yourself	0.3	0.4	1.4	-0.7	0.0	0.8	0.8	0.0	0.4	1.2	0.5	0.5	0.1
High blood pressure	0.3	0.9	2.5	-1.6	-0.0	0.7	1.5	-0.1	-0.2	1.6	0.6	0.8	-0.1
Hayfever, allergic rhinitis or eczema	0.8	1.8	3.8	-0.8	1.4	1.6	1.5	0.5	1.3	1.4	1.9	-0.0	1.6
Multivitamins +/- minerals	0.2	0.3	0.9	0.4	-0.5	0.6	0.4	-0.9	-0.3	0.7	0.3	0.1	-0.4
Stomach or abdominal pain in last month	0.8	1.0	2.6	-0.5	0.7	-1.6	-1.3	-0.5	-0.9	-1.6	-1.0	-0.7	0.2
Supplements: Glucosamine	2.3	3.0	7.0	0.6	1.3	2.6	1.6	2.1	2.4	1.6	1.1	1.3	1.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	3.1	-1.8	-0.2	-0.8	-0.1	-0.2	-0.6	-0.0	-0.2	1.0	-0.1
Medication: Atenolol	0.9	1.1	2.6	0.6	-1.3	-1.3	-0.3	-0.9	-0.9	-0.5	-0.6	-1.5	-1.6
Medication: Levothyroxine sodium	0.9	1.5	11.2	3.3	-0.1	-0.2	-0.8	-0.7	-0.1	-1.1	-1.3	-0.2	-0.3
Sitting height	0.1	0.8	4.3	2.1	-0.1	-0.7	-1.0	-0.2	-0.7	-1.0	-0.9	0.1	-0.2
Chronic bronchitis/emphysema (father)	2.4	2.8	3.9	1.3	1.8	1.3	2.0	1.5	1.9	1.8	1.8	1.6	1.8
High blood pressure (mother)	2.8	4.0	9.7	-1.2	-2.3	-1.6	-1.2	-2.8	-3.1	-1.2	-1.4	-1.3	-2.6
Body mass index (BMI)	0.8	3.5	9.4	1.1	2.4	2.0	0.8	2.4	3.1	0.1	1.2	1.5	2.2
Impedance of leg (left)	0.6	3.0	9.7	0.0	-2.3	-0.8	-1.3	-3.1	-2.4	-0.5	-1.5	-1.0	-2.0
Leg predicted mass (left)	0.4	2.0	4.8	2.2	1.7	0.4	0.1	1.9	1.7	-0.3	0.6	1.6	1.6
Trunk fat mass	0.4	1.5	9.9	3.1	0.6	0.8	-0.7	0.7	1.1	-1.0	-0.5	0.7	0.5
Waist circumference	0.5	1.7	3.3	1.6	1.7	1.0	0.1	1.6	1.8	-0.1	0.5	1.3	1.6
Number of incorrect matches in round	0.3	0.6	1.2	-0.8	0.1	0.1	1.1	1.0	0.5	1.1	0.7	-0.9	0.0
Past tobacco smoking	0.6	1.0	3.4	1.9	0.9	0.6	-0.5	1.0	1.7	-0.9	-0.3	-0.2	0.7
Alcohol usually taken with meals	0.2	0.4	1.8	1.3	-0.4	-0.6	0.2	-0.3	-0.4	1.2	0.1	-0.0	0.0
Nervous feelings	0.4	0.8	4.4	-0.6	-0.6	-2.1	-0.7	-0.0	-1.3	-0.6	-0.6	-0.3	-0.5
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.7	4.1	-1.9	1.8	2.0	1.7	1.6	0.8	1.5	2.0	0.5	1.7
Hearing difficulty/problems with background noise	0.3	0.4	1.2	0.5	0.7	0.3	0.3	0.7	0.4	0.4	0.6	1.1	0.8
Hair/balding pattern: Pattern 2	2.3	2.9	6.6	0.2	-2.6	-1.5	-1.4	-1.9	-2.0	-1.4	-1.1	-1.3	-2.3
Had menopause	0.4	0.5	1.5	0.7	-1.2	-0.4	-0.6	-0.5	-0.3	-0.2	-0.8	-0.3	-1.1
Had other major operations	0.2	0.2	1.3	1.2	-0.0	0.4	-0.0	-0.2	-0.0	0.3	0.2	-0.5	0.1
Forced vital capacity (FVC)	0.0	0.2	0.6	-0.8	-0.0	-0.5	-0.3	-0.0	-0.4	-0.6	-0.2	0.4	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.0	-0.8	-1.0	-0.3	-1.6	-0.3	-0.7	-1.7	-1.7	-0.1	-1.0
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.2	-1.0	0.7	1.1	1.7	0.1	0.5	1.7	1.8	0.1	0.5
Qualifications: None of the above	0.4	0.8	3.6	0.5	1.3	1.9	-0.0	0.7	1.0	-0.3	-0.0	0.1	0.9
Financial difficulties in last 2 years	0.3	0.4	2.0	-0.7	-0.3	-0.6	-0.5	-0.4	-0.5	-0.6	-0.1	-1.4	-0.4
Mouth/teeth dental problems	0.7	1.0	3.4	0.6	-0.4	1.5	1.2	0.1	1.1	1.8	1.0	0.0	-0.2
Heart attack	3.6	4.6	7.4	0.7	-2.2	-2.3	-2.2	-1.8	-1.9	-2.3	-2.2	-2.7	-2.4
Allergy	0.9	2.1	4.3	0.8	-2.1	-1.8	-1.3	-1.0	-1.4	-1.1	-1.8	-0.0	-2.0
Pain all over the body in last month	0.2	0.2	0.6	-0.5	0.1	0.4	-0.0	0.8	0.4	-0.3	0.2	0.6	0.0
Diabetes (self-reported)	0.3	0.5	2.3	1.2	-0.3	0.8	0.1	-0.1	0.1	0.2	-0.6	1.5	-0.2
Hayfever/allergic rhinitis (self-reported)	1.8	2.3	5.9	-0.9	1.6	2.4	1.4	0.9	1.6	1.8	1.5	0.6	1.7
Medication: Ramipril	1.8	2.3	6.0	-0.4	-2.0	-2.4	-1.2	-0.9	-1.9	-0.9	-1.4	-0.7	-1.9
Medication: Simvastatin	0.5	0.8	2.3	0.4	-0.1	1.3	1.5	-0.4	0.0	1.5	1.2	-0.4	0.0
Fluid intelligence score	0.4	0.9	5.1	0.0	-1.5	-0.0	0.0	0.9	0.2	0.7	0.2	2.3	-0.6
Illnesses of siblings	0.5	0.7	4.6	-0.1	0.6	-0.2	-0.2	0.5	1.0	-0.5	-0.3	2.1	0.8
Neuroticism score	0.2	0.3	1.0	-1.0	0.3	-0.6	0.6	0.1	-0.7	0.5	0.6	-0.4	0.2
Weight	0.5	2.6	7.8	2.8	1.9	1.2	-0.0	1.6	2.1	-0.5	0.3	1.4	1.8
Impedance of arm (right)	0.8	3.8	8.3	0.5	-2.3	-1.6	-1.8	-2.6	-2.9	-0.8	-2.1	-1.2	-2.2
Arm fat percentage (right)	0.4	1.5	4.0	2.0	1.3	1.6	-0.2	1.1	2.0	-0.6	-0.1	0.7	1.1
Trunk fat-free mass	0.3	1.8	5.7	2.4	1.7	0.4	0.2	1.4	1.3	-0.1	0.5	1.5	1.7
Hip circumference	0.6	2.7	6.4	2.4	2.3	1.1	0.4	1.7	2.5	-0.1	0.8	0.9	2.0
Time employed in main current job	0.5	0.5	1.8	-0.5	-0.4	0.3	-0.9	-1.0	-1.3	-0.6	-0.7	0.2	-0.5
Alcohol intake versus 10 years previously	0.3	0.5	1.8	-1.3	0.6	1.0	0.7	0.4	0.6	0.3	0.6	-0.5	0.1
Father’s age at death	0.2	0.3	1.7	0.3	-0.2	0.0	0.3	0.1	-0.0	0.8	-0.1	1.3	-0.1
Worrier / anxious feelings	0.7	1.3	4.4	-0.4	-0.6	-2.1	-0.8	-1.0	-2.1	-0.7	-0.9	-0.5	-0.8
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	6.7	-1.1	2.6	1.5	1.5	0.9	0.8	1.3	1.5	0.1	2.1
Falls in the last year	2.0	2.7	5.1	1.3	2.2	0.9	1.4	2.2	1.8	1.1	1.9	-0.0	2.1
Hair/balding pattern: Pattern 3	0.4	0.6	2.1	0.2	0.2	1.0	1.1	-0.5	0.9	1.4	0.7	-0.6	0.1
Number of live births	0.5	0.8	2.9	-0.1	0.1	0.6	1.4	0.1	-0.6	0.7	1.7	-1.2	-0.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.0	-0.1	-0.4	-0.4	-0.8	-0.6	-0.3	-1.0	-0.7	0.3	-0.5
Pulse rate	1.1	1.9	7.0	0.1	1.8	1.4	0.2	1.7	2.6	0.2	0.3	0.8	1.7
Happiness	0.5	0.6	1.7	-0.3	1.1	0.6	-0.6	0.7	1.3	-0.8	-0.2	0.3	1.1
Noisy workplace	0.4	0.5	1.4	-0.9	1.1	0.7	0.2	0.6	1.2	-0.3	0.0	-0.3	0.8
Qualifications: A levels/AS levels or equivalent	0.4	1.0	5.7	-0.5	-0.4	-0.8	0.6	0.2	0.2	1.4	0.6	2.4	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.7	-0.9	0.6	0.2	1.2	1.0	1.3	0.6	0.9	0.7	0.6
Mouth/teeth dental problems: Dentures	0.3	0.5	1.3	0.6	0.9	0.8	0.5	0.5	0.6	0.2	0.5	1.1	0.8
Asthma	0.8	1.6	2.4	-0.6	1.5	1.2	1.3	1.4	1.0	1.3	1.5	1.1	1.5
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	3.5	0.7	1.9	-0.6	0.3	0.7	0.9	0.0	0.6	0.6	1.5
Medication: Cholesterol lowering	2.7	4.3	8.3	-0.3	-2.8	-1.9	-1.0	-2.4	-2.9	-0.5	-1.4	-2.4	-2.8
Depression (self-reported)	0.2	0.2	1.0	0.0	-0.3	-0.6	-0.0	-0.6	-0.1	0.1	-0.1	-1.0	-0.6
Medication: Lansoprazole	0.3	0.3	1.2	0.9	-0.0	0.1	-0.1	-0.1	-0.7	-0.4	-0.2	-1.1	-0.5
Prospective memory result	4.0	4.9	6.8	2.6	-2.1	-2.4	-2.2	-1.7	-1.6	-2.4	-2.6	-1.8	-2.5
Lung cancer (father)	0.4	0.4	1.6	1.3	0.3	1.2	-0.2	-0.9	-0.1	0.1	-0.3	0.5	0.1
Illnesses of mother	1.2	1.5	4.3	0.3	1.8	0.5	0.0	1.7	1.7	0.2	0.4	1.1	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.7	0.7	0.1	0.1	-0.5	0.3	0.4	-0.9	-0.3	0.8	0.1
Pulse wave Arterial Stiffness index	0.2	0.3	0.6	-0.1	0.4	0.6	0.6	-0.5	0.7	0.8	0.6	-0.3	0.4
Impedance of arm (left)	0.5	2.3	6.2	0.7	-1.9	-1.2	-1.2	-2.1	-2.5	-0.5	-1.6	-0.5	-1.7
Arm fat mass (right)	0.6	2.3	4.9	2.2	1.9	1.4	-0.1	1.7	2.2	-0.6	0.2	1.3	1.7
Trunk predicted mass	0.3	1.9	5.8	2.4	1.8	0.5	0.2	1.4	1.3	-0.1	0.5	1.6	1.7
Standing height	0.3	3.1	15.0	3.9	-0.9	-1.6	-1.7	-1.4	-1.8	-1.1	-1.7	0.3	-0.7
Length of working week for main job	0.2	0.2	1.0	0.1	-0.2	1.0	0.6	-0.1	-0.1	0.8	0.3	0.4	0.0
Exposure to tobacco smoke at home	0.2	0.2	1.8	-1.3	-0.1	-0.2	0.1	0.5	-0.0	-0.1	0.2	-0.3	-0.2
Breastfed as a baby	1.4	1.7	7.8	-0.6	1.2	1.2	0.8	0.9	0.9	1.0	1.0	2.8	1.5
Tense / ‘highly strung’	0.2	0.4	0.9	-0.7	0.6	0.2	1.0	0.6	0.0	0.6	1.0	-0.6	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	5.1	-1.4	1.4	0.1	2.0	1.7	1.8	1.8	2.3	0.3	1.3
Hair/balding pattern: Pattern 4	0.1	0.3	1.5	-1.2	0.0	-1.1	0.4	-0.0	-0.5	0.4	0.1	0.1	-0.0
Birth weight of first child	0.4	0.7	3.2	-1.8	0.5	-1.0	-0.5	0.9	0.4	-0.9	-0.4	0.7	0.3
Peak expiratory flow (PEF)	0.2	0.4	0.9	1.0	-0.4	-0.6	-0.4	-0.9	-0.3	-0.6	-0.4	-0.7	-0.5
Pulse wave reflection index	0.3	0.3	0.9	0.3	-0.4	0.7	0.6	-0.9	0.0	0.8	0.6	-0.4	-0.4
Ever highly irritable/argumentative for 2 days	0.5	0.6	3.1	1.8	0.9	0.7	0.3	-0.1	0.5	0.2	0.5	-0.3	0.7
Loud music exposure frequency	0.2	0.2	1.4	-0.1	0.4	-0.2	-0.2	-0.1	-0.4	-0.0	-0.5	1.2	0.3
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.7	-0.8	0.6	0.0	1.2	0.6	0.5	1.8	1.1	1.9	1.2
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	6.8	-0.8	0.1	-2.3	-2.0	0.0	-1.3	-2.6	-1.4	-1.1	-0.2
Blood clot in the leg (DVT)	0.6	0.7	2.0	-0.8	1.4	1.0	0.5	0.4	1.0	0.1	0.7	-0.9	1.0
Medication: Paracetamol	0.3	0.5	1.7	1.3	-0.7	-0.5	-0.2	-0.1	-0.9	-0.0	-0.6	0.8	-0.7
Headache pain in last month	0.3	0.6	1.8	-0.6	1.4	-0.1	0.5	-0.1	-0.2	0.7	0.9	0.7	1.2
Medication for cholesterol, blood pressure or diabetes	3.0	5.0	10.9	0.3	3.3	2.0	1.2	2.2	2.9	0.6	1.8	2.4	3.3
Glaucoma (self-reported)	1.7	2.0	3.9	2.0	1.1	0.6	1.3	1.6	1.5	1.3	0.9	1.7	1.5
Gout (self-reported)	0.7	0.9	2.0	1.3	-0.3	0.5	1.3	0.5	0.6	1.4	1.0	-1.3	-0.2
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	12.5	3.5	-0.6	-0.2	-1.1	-0.6	-0.2	-1.4	-1.5	-0.3	-0.7
Medication: Amlodipine	0.4	0.5	1.6	-0.3	-0.6	-1.2	-0.6	-0.2	-0.9	-1.0	-0.7	-0.4	-0.7
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.0	1.4	0.1	-0.4	-1.4	0.2	0.0	-1.7	-1.2	-1.2	-0.2
Birth weight	0.1	0.3	1.3	0.3	0.1	0.3	0.6	0.6	0.3	0.4	0.7	1.1	0.4
Chronic bronchitis/emphysema (mother)	1.0	1.1	3.8	1.3	-0.3	0.2	-0.5	-1.9	-0.7	-0.3	-0.9	-2.0	-0.7
High blood pressure (siblings)	0.4	0.5	3.0	1.4	-0.3	-0.2	-0.3	0.1	-0.3	-0.0	-0.1	-1.7	-0.5
Forced vital capacity (FVC), Best measure	0.0	0.1	0.6	0.4	0.0	-0.2	-0.3	0.3	-0.2	-0.8	-0.2	0.6	-0.0
Body fat percentage	0.4	1.5	6.2	2.5	1.0	1.5	-0.1	0.8	1.7	-0.5	-0.0	0.9	0.9
Leg fat percentage (right)	0.7	2.4	5.4	1.6	1.9	2.2	0.1	1.2	2.3	-0.4	0.3	1.4	1.8
Arm fat-free mass (right)	0.4	2.3	3.8	1.9	1.7	0.7	0.6	1.9	1.8	0.1	1.1	1.9	1.8
Exposure to tobacco smoke outside home	0.7	0.9	5.9	-2.4	0.9	-0.3	0.1	0.9	-0.2	0.0	0.7	0.4	0.9
Comparative body size at age 10	0.6	1.7	3.5	-1.9	1.5	-0.7	-1.0	1.6	1.6	-1.6	-0.6	-0.5	1.1
Number of full brothers	0.5	0.6	1.4	1.1	1.0	0.7	-0.8	-0.1	0.0	-0.9	-0.1	-1.2	0.6
Worry too long after embarrassment	1.5	2.5	4.6	-0.9	1.8	0.9	2.1	1.5	1.5	1.8	2.1	0.7	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.9	-0.8	0.3	-0.5	1.1	0.8	0.2	0.9	1.4	-0.2	0.2
Wheeze or whistling in the chest in last year	0.1	0.2	0.7	-0.8	0.2	-0.8	-0.2	0.7	-0.4	-0.7	0.0	0.1	0.2
Number of children fathered	1.9	2.2	4.2	1.2	-1.1	-1.0	-1.8	-1.8	-0.7	-2.0	-1.8	-1.2	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.2	-1.1	-1.4	-0.8	-0.3	-1.2	-1.8	-0.4	-0.4	-1.1	-1.4
Age at first live birth	0.5	0.9	3.8	-1.9	-0.9	-1.1	-0.0	-1.2	-0.8	0.6	-0.3	-0.7	-0.5
Pulse wave peak to peak time	0.2	0.3	0.6	0.1	-0.4	-0.7	-0.5	0.4	-0.8	-0.6	-0.6	0.5	-0.4
Health satisfaction	0.4	0.5	1.4	0.9	0.8	1.0	0.0	0.3	1.2	0.0	0.3	-0.2	0.7
Shortness of breath walking on level ground	1.2	1.4	5.0	-0.7	1.9	0.8	0.7	2.2	1.0	0.2	0.9	0.4	1.5
Qualifications: College or University degree	0.3	0.9	4.9	-0.3	-1.6	-2.2	-0.6	0.2	-0.4	-0.3	-0.3	-0.1	-1.1
Eye problems/disorders: None of the above	0.8	0.9	3.7	-1.9	-0.4	-0.7	0.2	-0.7	0.1	0.2	0.6	-1.9	-0.6
Mouth/teeth dental problems: Loose teeth	0.5	0.5	2.9	0.7	-0.0	-0.7	-0.5	0.3	0.4	-0.9	-0.3	-1.7	-0.4
Emphysema/chronic bronchitis	0.9	1.0	4.5	-0.3	1.3	2.1	1.0	0.5	0.6	0.6	0.7	0.3	0.9
Medication for pain relief, constipation, heartburn	0.1	0.2	1.5	-1.2	-0.5	0.1	0.1	0.4	0.0	-0.0	0.4	-0.3	-0.2
Neck or shoulder pain in last month	0.3	0.5	2.1	-0.1	1.4	-0.4	0.3	0.5	-0.7	-0.1	0.7	0.6	1.0
Medication: Blood pressure	1.6	2.7	6.6	-0.4	-2.5	-1.9	-0.4	-1.5	-2.1	0.2	-1.2	-1.6	-2.6
Angina (self-reported)	0.7	0.9	2.6	-0.9	0.1	-0.7	1.6	0.1	-0.2	1.6	1.5	-0.7	0.1
Migraine (self-reported)	0.3	0.3	1.0	1.0	0.7	0.8	0.6	-0.1	0.0	0.6	0.2	-0.2	0.6
Medication: Ibuprofen	0.4	0.5	1.9	0.7	1.4	-0.3	-0.1	0.4	0.5	-0.2	0.3	0.4	1.1
Medication: Allopurinol	0.6	0.8	5.2	0.9	-0.2	-0.7	0.4	-0.1	-0.1	0.8	0.4	-2.3	-0.4
Medication: Omeprazole	0.8	1.0	2.3	0.7	1.3	-0.4	1.5	0.5	0.2	1.4	1.3	-0.1	1.1
Medication: Seretide 50 evohaler	0.8	0.9	2.4	0.3	-0.1	-0.2	-1.6	0.4	-0.7	-1.5	-1.4	1.4	-0.1
Mean time to correctly identify matches	0.3	0.6	1.1	-0.9	-0.7	0.8	0.6	-0.5	-1.0	1.0	0.3	0.8	-0.6
Heart disease (mother)	0.4	0.5	1.8	1.0	-0.4	-0.7	0.5	-0.5	-0.3	0.8	-0.1	1.4	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	-0.5	0.2	0.7	0.2	-0.6	0.2	-0.5	-0.1	-0.6	-0.1
Whole body fat mass	0.5	2.1	7.9	2.8	1.5	1.3	-0.2	1.3	1.9	-0.7	0.1	1.3	1.4
Leg fat mass (right)	0.8	2.9	6.5	2.2	2.1	1.8	0.3	1.7	2.5	-0.2	0.6	1.5	2.0
Arm predicted mass (right)	0.5	2.7	4.5	2.0	2.0	0.9	0.8	2.1	2.0	0.4	1.2	1.9	2.0
Pulse rate, automated reading	2.0	6.6	16.1	-0.6	2.8	3.3	1.1	3.0	4.0	1.3	1.7	2.1	3.3
Alcohol intake frequency.	0.3	0.7	2.8	1.0	1.1	0.5	-0.4	0.4	0.5	-0.7	-0.3	-1.7	0.5
Comparative height size at age 10	0.3	1.7	6.9	2.6	-0.1	-0.9	-1.4	-1.3	-1.1	-1.5	-1.4	-0.1	-0.2
Number of full sisters	1.5	1.9	4.2	0.8	-0.9	-1.3	-1.6	-1.2	-0.7	-1.9	-1.1	-2.0	-1.3
Suffer from ‘nerves’	0.6	0.9	4.0	-2.0	0.5	-1.1	-0.6	0.2	-0.8	-0.6	-0.2	-1.6	0.2
Overall health rating	0.5	1.1	4.9	-1.0	2.2	0.3	0.5	1.0	0.7	0.2	0.8	0.2	1.6
Chest pain or discomfort	0.5	0.7	1.8	-0.7	0.9	0.9	0.9	0.6	-0.2	0.8	1.4	0.2	1.0
Had major operations	1.0	1.2	2.5	1.2	1.3	1.4	0.4	1.5	1.6	-0.2	0.4	0.2	1.1
Age at last live birth	0.5	0.8	3.0	-1.2	-0.2	-1.0	0.4	-0.9	-0.7	0.9	0.4	-1.7	-0.1
Family relationship satisfaction	0.5	0.6	2.3	-1.0	1.5	0.1	-0.2	0.6	0.9	-0.1	0.2	0.4	1.3
Leg pain on walking	0.7	0.9	1.2	1.0	0.9	0.7	1.0	1.1	0.8	1.0	1.0	1.0	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.6	0.1	-0.7	-1.0	-1.0	-0.8	-1.6	-0.9	-0.6	-1.1	-0.8
Commuting to job workplace: Car/motor vehicle	1.2	1.3	3.6	1.9	1.6	1.7	1.2	-0.2	0.7	0.7	0.6	-0.1	1.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.8	1.7	-0.8	1.4	-0.2	-0.9	-0.8	0.1	-0.6	-0.2	-0.6
Medication: Aspirin	0.2	0.2	1.6	1.2	0.2	-0.4	-0.1	-0.1	0.3	0.2	-0.3	-0.2	0.1
Supplements: Vitamin C	0.3	0.4	1.2	1.0	-0.5	-0.7	0.2	-0.6	-1.1	0.4	-0.1	-0.3	-0.3
Knee pain experienced in last month	0.3	0.5	2.3	0.7	0.4	0.8	0.3	-1.5	-0.7	0.5	0.0	-0.9	-0.1
Hypertension (Self-reported)	0.4	1.2	4.6	-2.1	0.1	0.7	1.6	0.0	-0.2	1.6	0.7	1.2	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	3.6	1.0	-0.3	-0.0	-0.8	-1.3	-1.2	-1.0	-1.9	-0.5	-1.0
Illnesses of father: Heart disease	0.9	1.3	4.5	1.1	-0.2	-1.6	-1.6	0.8	0.1	-2.1	-1.1	0.2	0.1
Illnesses of siblings: Diabetes	0.6	0.8	3.1	1.0	0.9	0.8	0.4	0.4	0.8	0.7	0.4	-1.8	0.7
Smoking status: Previous	0.4	0.6	2.0	-0.7	-0.9	-0.1	0.4	-0.9	-1.4	0.9	0.1	-0.0	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	3.2	1.8	-0.0	0.5	-0.7	-0.3	-0.4	-0.7	-0.8	0.3	-0.0
Whole body fat-free mass	0.3	1.9	5.6	2.4	1.7	0.3	0.1	1.6	1.4	-0.2	0.6	1.6	1.6
Leg fat-free mass (right)	0.3	1.7	5.2	2.3	1.5	0.1	0.1	1.9	1.6	-0.3	0.6	1.3	1.4
Arm fat percentage (left)	0.5	2.2	5.3	2.1	1.7	1.7	0.1	1.6	2.3	-0.4	0.3	1.3	1.4
Average weekly red wine intake	0.7	1.0	2.3	1.3	-0.6	-1.4	-1.5	-0.4	-0.2	-1.1	-1.3	-0.3	-0.5
Handedness (chirality/laterality): Left-handed	3.7	4.5	9.6	1.9	-1.8	-1.8	-1.6	-3.1	-2.1	-1.6	-1.8	-2.6	-2.3
Mood swings	0.5	0.9	5.9	-2.4	0.2	-0.0	0.1	-0.7	-1.4	0.1	-0.0	1.0	-0.0
Loneliness, isolation	0.2	0.3	0.9	-0.5	0.3	-0.4	-0.6	0.4	-0.2	-0.9	-0.1	-0.8	0.0
Long-standing illness, disability or infirmity	0.8	1.2	3.3	-0.2	1.6	0.3	0.6	1.8	1.1	0.7	0.7	1.1	1.5
Ever had bowel cancer screening	0.6	0.7	2.8	-1.4	-0.6	0.5	0.1	-0.8	0.4	-0.0	-0.0	-1.7	-0.7
Diabetes diagnosed by doctor	0.3	0.5	3.2	0.7	-0.3	1.0	-0.1	0.0	-0.1	0.1	-0.7	1.8	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.8	-0.2	0.4	-0.6	0.0	-0.9	-1.3	0.0	0.4	-0.5	0.1
Friendships satisfaction	0.3	0.4	0.8	0.1	0.8	0.8	-0.4	0.7	0.7	-0.4	-0.2	0.9	0.7
Qualifications: nursing, teaching	0.6	1.0	3.5	0.7	-0.8	-1.9	-1.0	-0.9	-0.6	-0.7	-1.1	-0.1	-1.0
Commuting to job workplace: Walk	0.8	0.9	2.2	-0.2	-0.9	-1.2	-1.5	-0.2	-1.2	-1.0	-0.9	-0.8	-0.8
Eye problems/disorders: Cataract	0.2	0.3	0.7	0.7	-0.0	-0.3	-0.5	-0.3	-0.7	-0.4	-0.8	0.8	0.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.0	-0.7	0.8	-1.4	0.1	-0.3	-0.8	0.4	-0.3	1.1	0.7
Medication for cholesterol	0.5	0.8	3.1	0.1	-0.7	-1.6	-0.2	-0.3	-1.1	0.1	0.2	-1.8	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.4	4.0	-1.0	1.1	2.0	1.3	0.5	0.6	1.3	0.8	1.0	1.1
Back pain experienced in last month	0.5	0.8	4.0	1.1	2.0	-0.2	0.4	-0.5	0.5	-0.0	0.3	-0.3	1.2
Mineral and other dietary supplements	0.6	0.8	3.5	-1.9	-0.1	-0.6	-0.9	-0.3	-0.1	-1.2	-0.2	-1.4	-0.2
Breast cancer (self-reported)	1.3	1.5	3.5	1.2	-1.9	-1.0	-0.9	-1.1	-0.8	-0.7	-0.8	-1.5	-1.7
Asthma (self-reported)	1.3	2.7	4.1	-0.8	2.0	1.3	1.8	1.7	1.2	1.8	2.0	1.3	2.0
Osteoporosis (self-reported)	0.4	0.5	1.4	1.2	0.9	0.4	0.8	0.9	0.6	0.1	0.8	-0.1	0.6
Osteoarthritis (self-reported)	0.6	0.7	1.9	0.2	1.4	0.0	0.5	0.9	0.4	0.9	0.4	1.1	1.3
Medication: Aspirin	0.3	0.4	1.9	1.4	0.5	0.4	0.3	0.3	0.7	0.5	0.1	0.4	0.5
Medication: Gliclazide	3.0	3.4	8.0	2.2	-2.6	-0.4	-1.6	-1.6	-1.3	-1.8	-1.9	-1.0	-2.8
Illnesses of father: None of the above (group 1)	0.8	1.0	3.5	-1.9	-1.0	0.5	0.8	-0.8	-0.9	1.2	0.8	-0.8	-0.8
Smoking status: Current	0.3	0.5	2.1	-1.2	0.6	-0.2	0.7	0.3	-0.4	0.2	1.4	-0.3	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	3.2	-0.2	0.5	0.9	-0.4	0.6	1.2	-0.4	-0.2	1.8	0.6
Whole body water mass	0.3	1.9	5.2	2.3	1.7	0.4	0.2	1.7	1.6	-0.1	0.6	1.5	1.6
Leg predicted mass (right)	0.3	1.7	5.3	2.3	1.4	0.0	0.0	1.8	1.5	-0.3	0.6	1.2	1.3
Arm fat mass (left)	0.8	3.2	7.0	2.3	2.3	1.9	0.4	2.0	2.6	-0.2	0.7	1.5	2.0
Number of self-reported non-cancer illnesses	1.3	2.3	4.1	-0.3	1.9	1.9	2.0	1.0	1.5	2.0	1.3	0.5	1.6
Average weekly champagne plus white wine intake	0.5	0.8	3.6	-1.6	-0.7	-0.2	-0.3	-0.2	-0.6	0.4	-0.4	1.9	-0.0
Miserableness	0.5	0.8	1.8	-1.1	1.4	0.7	0.8	-0.7	-0.1	0.8	0.7	1.1	1.2
Guilty feelings	0.5	0.7	2.3	-1.5	0.8	-0.7	0.5	1.2	0.3	0.2	1.0	0.2	0.8
Wears glasses or contact lenses	0.4	0.5	1.3	1.0	-0.2	0.8	0.3	-1.0	-0.5	0.3	-0.2	-1.2	-0.4
Ever taken oral contraceptive pill	1.3	1.4	4.4	-0.4	-2.1	-0.5	-0.8	-1.5	-1.2	-0.5	-1.1	-0.6	-1.9
Hearing aid user	1.5	1.7	3.1	-0.0	-1.2	-1.5	-1.8	-0.8	-1.7	-1.6	-1.4	-0.9	-1.2
Mother’s age at death	1.2	1.5	4.6	0.2	0.7	0.8	1.6	1.1	1.6	2.1	1.2	0.9	1.1
Financial situation satisfaction	0.5	0.6	2.0	0.5	1.4	1.0	0.1	0.4	0.4	0.1	0.6	-1.0	1.1
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.6	-0.1	-1.2	-1.1	-1.6	-0.4	-0.7	-1.1	-1.4	-1.2	-1.1
Commuting to job workplace: Public transport	0.5	0.5	2.8	-0.4	-1.7	-0.6	-0.5	-0.4	-0.2	0.1	-0.4	-0.5	-1.1
Eye problems/disorders: Glaucoma	3.5	4.1	8.3	2.9	2.2	1.4	1.2	2.0	2.2	1.1	1.0	2.6	2.5
Medication: Blood pressure	0.2	0.4	2.9	0.1	0.2	1.0	0.2	0.2	0.6	-0.2	-0.1	1.7	0.1
Pain type(s) experienced in last month: Hip pain	4.5	5.6	11.7	0.8	3.4	3.0	1.9	2.3	3.0	1.6	2.1	0.7	3.1
Supplements: Fish oil (including cod liver oil)	1.3	1.7	4.0	2.0	-1.6	-0.8	-0.6	-1.2	-1.9	0.1	-1.3	0.8	-1.5
High cholesterol (Self-reported)	0.1	0.2	1.1	-0.5	0.1	1.0	0.3	-0.2	0.1	0.4	-0.1	0.3	0.1
Medication: Bendroflumethiazide	0.5	0.8	2.3	0.3	-0.6	0.9	1.2	-1.2	-0.1	1.5	0.6	0.6	-0.6
Medication: Paracetamol	0.1	0.2	0.8	0.9	-0.6	0.1	0.1	0.2	-0.4	0.1	-0.2	0.6	-0.5
Medication: Lisinopril	0.7	0.9	1.9	-0.8	0.1	1.4	1.1	0.4	1.1	1.4	0.6	1.0	0.1
Medication: Atorvastatin	2.2	2.7	6.4	-0.7	-1.2	-1.1	-2.5	-0.9	-1.7	-2.2	-2.5	-0.9	-1.5
Illnesses of father: High blood pressure	0.3	0.4	1.1	0.4	1.0	-0.3	0.5	0.9	0.6	0.1	0.4	-0.5	0.7
Alcohol drinker status: Never	1.7	2.0	4.6	1.5	2.1	0.1	1.0	1.7	1.7	0.9	1.4	0.1	1.9
Ever smoked	0.6	1.1	6.0	-2.4	-0.4	-0.9	0.4	-0.5	-1.5	0.7	0.6	0.2	-0.2
Basal metabolic rate	0.4	2.2	6.2	2.5	1.9	0.6	0.1	1.7	1.8	-0.2	0.6	1.6	1.8
Leg fat percentage (left)	0.5	1.9	5.0	2.0	1.5	1.9	0.1	1.0	2.2	-0.4	0.4	1.0	1.4
Arm fat-free mass (left)	0.4	2.3	4.0	1.8	2.0	1.2	0.7	1.8	2.0	0.4	1.2	1.2	1.9
Number of operations (self-reported)	0.3	0.4	1.7	1.3	0.7	0.9	0.1	0.3	0.5	0.0	0.0	-0.7	0.6
Average weekly beer plus cider intake	3.5	5.0	7.8	-2.1	2.4	1.6	2.3	2.0	1.6	2.2	2.8	2.3	2.7
Irritability	1.1	1.9	3.6	-1.1	1.1	1.1	1.8	1.2	0.7	1.6	1.9	1.4	1.3
Risk taking	1.3	1.9	10.3	-3.2	0.8	-0.5	1.1	0.9	-0.1	0.8	1.1	1.6	0.9
Ever had prostate specific antigen (PSA) test	0.4	0.5	2.4	0.3	-0.3	-0.2	0.6	-1.6	-0.4	1.1	-0.0	-0.7	-0.4
Fractured/broken bones in last 5 years	0.2	0.2	0.9	0.7	0.2	-1.0	-0.2	0.4	-0.0	-0.1	-0.3	-0.6	-0.0
Age started oral contraceptive pill	0.5	0.7	3.3	-0.1	-0.3	1.4	0.7	0.6	0.3	0.8	0.1	1.8	0.1
Diastolic blood pressure, automated reading	1.6	4.9	12.1	-1.5	2.3	3.5	1.2	2.3	2.8	0.7	1.4	2.5	2.4
Ever depressed for a whole week	0.7	0.9	3.8	-1.2	0.8	-0.4	0.5	0.8	0.9	-0.2	0.9	-2.0	0.4
Unable to work because of sickness or disability	0.3	0.4	1.8	0.2	0.8	1.4	0.1	0.7	0.7	-0.1	0.4	-0.2	0.6
Commuting to job workplace: Cycle	0.8	1.0	7.3	-2.7	0.0	-0.0	0.3	0.9	-0.2	0.8	0.6	0.7	0.2
Myopia	1.0	1.5	3.3	-1.7	-1.8	-1.7	-0.6	-0.5	-0.9	-0.2	-1.0	-1.0	-1.5
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.2	1.7	-0.3	-0.6	-1.7	-0.4	-0.1	-1.8	-1.0	-0.7	-0.2
Cholesterol lowering medication	1.4	2.0	6.1	0.1	1.4	2.5	1.5	0.6	1.1	1.4	1.2	1.7	1.4
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	3.8	0.2	1.5	0.7	2.0	1.0	0.8	1.8	1.7	0.6	1.4
Pain experienced in last month	0.6	1.0	4.8	-1.5	-2.2	-0.5	-0.4	-0.1	-0.5	0.3	-0.5	0.1	-1.2
Supplements: Calcium	1.4	1.6	3.5	-0.3	0.9	1.5	1.7	0.3	0.5	1.9	1.4	1.8	0.8
Basal cell carcinoma (self-reported)	0.5	0.5	3.2	1.8	-0.5	-0.1	-0.7	0.0	-0.1	-0.5	-1.0	0.3	-0.5
Heart attack/myocardial infarction (self-reported)	3.7	4.7	6.6	0.9	-2.3	-2.2	-2.3	-1.9	-2.0	-2.4	-2.3	-2.6	-2.4
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	-0.5	1.1	1.0	0.5	0.3	0.8	0.1	0.5	-0.7	0.7
Heart disease (siblings)	0.5	0.6	1.8	0.4	-0.6	0.7	0.2	-1.3	-0.8	0.1	-0.0	-1.3	-1.0
Alcohol drinker status: Previous	0.6	0.7	1.8	1.4	-1.3	-0.3	-0.3	-0.7	-1.1	0.2	-0.9	-0.1	-1.0
Pack years of smoking	0.2	0.3	0.9	0.7	0.4	-0.6	-0.4	0.6	-0.1	-0.9	-0.1	-0.4	-0.0
Impedance of whole body	0.6	3.1	7.8	0.4	-2.2	-1.0	-1.4	-2.8	-2.7	-0.5	-1.7	-0.6	-2.0
Leg fat mass (left)	0.6	2.3	5.4	2.3	1.8	1.4	0.3	1.5	2.3	-0.3	0.7	1.2	1.6
Arm predicted mass (left)	0.4	1.9	3.6	1.7	1.9	1.0	0.4	1.6	1.8	0.0	0.8	1.4	1.9