Hub : Traits :

Average weekly spirits intake

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 48712791 50100066 1 1 2.5e-07 6.5e-07 0.28 95 RHOA-IT1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 41.61 1 1 3 0 1 RHOA-IT1
Irritable Bowel Disease (IBD) 56.21 1 1 3 0 1 RHOA-IT1
Ulcerative Colitis (UC) 39.14 1 1 3 0 1 RHOA-IT1
Reaction Time 3.95 1 0 0 0 1 RHOA-IT1
Verbal and Numeric Reasoning (VNR) 14.21 1 1 3 0 1 RHOA-IT1
Breast Cancer 3.63 1 0 0 0 1 RHOA-IT1
Prostate Cancer 5.91 1 0 0 0 1 RHOA-IT1
Age at First Birth 7.58 1 0 0 0 1 RHOA-IT1
Coronary Artery Disease (CAD) 3.94 1 0 0 0 1 RHOA-IT1
Crohns Disease (2012) 35.49 1 1 3 0 1 RHOA-IT1
Fasting Glucose 6.99 1 0 0 0 1 RHOA-IT1
Neuroticism 3.04 1 0 0 0 1 RHOA-IT1
Schizophrenia 1.76 1 0 0 0 1 RHOA-IT1
Ulcerative Colitis 38.31 1 1 3 0 1 RHOA-IT1
Blood Platelet Count 1.65 1 0 0 0 1 RHOA-IT1
Blood White Count 2.13 1 0 0 0 1 RHOA-IT1
Heel T-Score 2.90 1 0 0 0 1 RHOA-IT1
BMI 7.73 1 1 3 0 1 RHOA-IT1
Height 0.51 1 0 0 0 1 RHOA-IT1
Waist Hip Ratio (WHR) 1.99 1 0 0 0 1 RHOA-IT1
Lung FVC 2.31 1 0 0 0 1 RHOA-IT1
Chronotype (morning person) 2.26 1 0 0 0 1 RHOA-IT1
Tanning 0.33 1 0 0 0 1 RHOA-IT1
Hand grip strength (left) 4.77 1 0 0 0 1 RHOA-IT1
Number of treatments/medications taken 3.98 1 0 0 0 1 RHOA-IT1
Sensitivity / hurt feelings 4.14 1 0 0 0 1 RHOA-IT1
Other serious medical condition/disability diagnosed by doctor 7.54 1 0 0 0 1 RHOA-IT1
Ever had hysterectomy (womb removed) 4.48 1 0 0 0 1 RHOA-IT1
Medication: Co-codamol 7.23 1 0 0 0 1 RHOA-IT1
Impedance of leg (right) 0.86 1 0 0 0 1 RHOA-IT1
Leg fat-free mass (left) 1.99 1 0 0 0 1 RHOA-IT1
Trunk fat percentage 8.39 1 1 3 0 1 RHOA-IT1
Hand grip strength (right) 5.08 1 0 0 0 1 RHOA-IT1
Current tobacco smoking 3.01 1 0 0 0 1 RHOA-IT1
Fed-up feelings 13.98 1 1 3 0 1 RHOA-IT1
Frequency of unenthusiasm / disinterest in last 2 weeks 4.85 1 0 0 0 1 RHOA-IT1
Taking other prescription medications 7.05 1 0 0 0 1 RHOA-IT1
Age when periods started (menarche) 4.92 1 0 0 0 1 RHOA-IT1
Heel bone mineral density (BMD) T-score, automated (left) 3.17 1 0 0 0 1 RHOA-IT1
Tinnitus: Yes, but not now, but have in the past 9.20 1 0 0 0 1 RHOA-IT1
Qualifications: CSEs or equivalent 4.49 1 0 0 0 1 RHOA-IT1
High blood pressure (mother) 4.08 1 0 0 0 1 RHOA-IT1
Body mass index (BMI) 8.43 1 1 3 0 1 RHOA-IT1
Impedance of leg (left) 1.04 1 0 0 0 1 RHOA-IT1
Leg predicted mass (left) 1.87 1 0 0 0 1 RHOA-IT1
Trunk fat mass 6.93 1 1 3 0 1 RHOA-IT1
Waist circumference 1.83 1 0 0 0 1 RHOA-IT1
Frequency of tenseness / restlessness in last 2 weeks 3.25 1 0 0 0 1 RHOA-IT1
Had menopause 5.69 1 0 0 0 1 RHOA-IT1
Forced vital capacity (FVC) 2.39 1 0 0 0 1 RHOA-IT1
Heel bone mineral density (BMD) T-score, automated (right) 3.39 1 0 0 0 1 RHOA-IT1
Qualifications: None of the above 9.10 1 0 0 0 1 RHOA-IT1
Pain all over the body in last month 4.79 1 0 0 0 1 RHOA-IT1
Fluid intelligence score 10.68 1 0 0 0 1 RHOA-IT1
Weight 4.28 1 0 0 0 1 RHOA-IT1
Impedance of arm (right) 0.88 1 0 0 0 1 RHOA-IT1
Arm fat percentage (right) 9.18 1 1 3 0 1 RHOA-IT1
Hip circumference 2.88 1 0 0 0 1 RHOA-IT1
Alcohol intake versus 10 years previously 9.18 1 0 0 0 1 RHOA-IT1
Father's age at death 9.85 1 0 0 0 1 RHOA-IT1
Hair/balding pattern: Pattern 3 2.59 1 0 0 0 1 RHOA-IT1
Forced expiratory volume in 1-second (FEV1) 4.13 1 0 0 0 1 RHOA-IT1
Qualifications: A levels/AS levels or equivalent 25.69 1 1 3 0 1 RHOA-IT1
Mouth/teeth dental problems: Dentures 5.42 1 0 0 0 1 RHOA-IT1
Prospective memory result 3.98 1 0 0 0 1 RHOA-IT1
Forced expiratory volume in 1-second (FEV1), Best measure 4.08 1 0 0 0 1 RHOA-IT1
Impedance of arm (left) 0.94 1 0 0 0 1 RHOA-IT1
Arm fat mass (right) 8.49 1 1 3 0 1 RHOA-IT1
Standing height 0.69 1 0 0 0 1 RHOA-IT1
Hair/balding pattern: Pattern 4 1.61 1 0 0 0 1 RHOA-IT1
Peak expiratory flow (PEF) 3.68 1 0 0 0 1 RHOA-IT1
Loud music exposure frequency 5.15 1 0 0 0 1 RHOA-IT1
Qualifications: O levels/GCSEs or equivalent 8.89 1 0 0 0 1 RHOA-IT1
Mouth/teeth dental problems: Bleeding gums 5.53 1 0 0 0 1 RHOA-IT1
Medication: Paracetamol 3.28 1 0 0 0 1 RHOA-IT1
Glaucoma (self-reported) 5.27 1 0 0 0 1 RHOA-IT1
Forced vital capacity (FVC), Best measure 2.56 1 0 0 0 1 RHOA-IT1
Body fat percentage 9.29 1 1 3 0 1 RHOA-IT1
Leg fat percentage (right) 8.96 1 1 3 0 1 RHOA-IT1
Arm fat-free mass (right) 0.92 1 0 0 0 1 RHOA-IT1
Exposure to tobacco smoke outside home 3.98 1 0 0 0 1 RHOA-IT1
Worry too long after embarrassment 5.15 1 0 0 0 1 RHOA-IT1
Wheeze or whistling in the chest in last year 9.29 1 0 0 0 1 RHOA-IT1
Age at first live birth 4.48 1 0 0 0 1 RHOA-IT1
Qualifications: College or University degree 30.39 1 1 3 0 1 RHOA-IT1
Medication: Seretide 50 evohaler 7.90 1 0 0 0 1 RHOA-IT1
Mean time to correctly identify matches 2.93 1 0 0 0 1 RHOA-IT1
Whole body fat mass 8.40 1 1 3 0 1 RHOA-IT1
Leg fat mass (right) 8.37 1 1 3 0 1 RHOA-IT1
Arm predicted mass (right) 1.10 1 0 0 0 1 RHOA-IT1
Pulse rate, automated reading 2.98 1 0 0 0 1 RHOA-IT1
Overall health rating 8.39 1 0 0 0 1 RHOA-IT1
Age at last live birth 7.88 1 0 0 0 1 RHOA-IT1
Leg pain on walking 6.10 1 0 0 0 1 RHOA-IT1
Qualifications: NVQ or HND or HNC or equivalent 4.06 1 0 0 0 1 RHOA-IT1
Leg fat-free mass (right) 1.35 1 0 0 0 1 RHOA-IT1
Arm fat percentage (left) 9.62 1 1 3 0 1 RHOA-IT1
Mood swings 2.94 1 0 0 0 1 RHOA-IT1
Loneliness, isolation 3.61 1 0 0 0 1 RHOA-IT1
Ever had bowel cancer screening 3.62 1 0 0 0 1 RHOA-IT1
Qualifications: nursing, teaching 9.05 1 0 0 0 1 RHOA-IT1
Osteoarthritis (self-reported) 4.05 1 0 0 0 1 RHOA-IT1
Smoking status: Current 3.24 1 0 0 0 1 RHOA-IT1
Leg predicted mass (right) 1.33 1 0 0 0 1 RHOA-IT1
Arm fat mass (left) 8.18 1 1 3 0 1 RHOA-IT1
Miserableness 6.67 1 0 0 0 1 RHOA-IT1
Guilty feelings 4.11 1 0 0 0 1 RHOA-IT1
Medication: Paracetamol 5.39 1 0 0 0 1 RHOA-IT1
Basal metabolic rate 1.40 1 0 0 0 1 RHOA-IT1
Leg fat percentage (left) 8.78 1 1 3 0 1 RHOA-IT1
Arm fat-free mass (left) 1.09 1 0 0 0 1 RHOA-IT1
Average weekly beer plus cider intake 6.50 1 0 0 0 1 RHOA-IT1
Diastolic blood pressure, automated reading 4.19 1 0 0 0 1 RHOA-IT1
Pain experienced in last month 5.84 1 0 0 0 1 RHOA-IT1
Impedance of whole body 0.94 1 0 0 0 1 RHOA-IT1
Leg fat mass (left) 8.59 1 1 3 0 1 RHOA-IT1
Arm predicted mass (left) 1.08 1 0 0 0 1 RHOA-IT1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.25
GTEx Adipose Visceral Omentum 0 0.0000 1.20
GTEx Adrenal Gland 0 0.0000 1.31
GTEx Artery Aorta 0 0.0000 1.24
GTEx Artery Coronary 0 0.0000 1.23
GTEx Artery Tibial 0 0.0000 1.25
GTEx Brain Caudate basal ganglia 0 0.0000 1.27
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.17
GTEx Brain Cerebellum 0 0.0000 1.22
GTEx Brain Cortex 0 0.0000 1.28
GTEx Brain Frontal Cortex BA9 0 0.0000 1.28
GTEx Brain Hippocampus 0 0.0000 1.25
GTEx Brain Hypothalamus 0 0.0000 1.16
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.25
GTEx Brain Putamen basal ganglia 0 0.0000 1.20
GTEx Breast Mammary Tissue 0 0.0000 1.23
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.29
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.14
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.25
GTEx Cells Transformed fibroblasts 0 0.0000 1.28
GTEx Colon Sigmoid 0 0.0000 1.26
GTEx Colon Transverse 0 0.0000 1.26
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.18
GTEx Esophagus Mucosa 0 0.0000 1.28
GTEx Esophagus Muscularis 0 0.0000 1.29
GTEx Heart Atrial Appendage 0 0.0000 1.24
GTEx Heart Left Ventricle 0 0.0000 1.38
GTEx Liver 0 0.0000 1.20
GTEx Lung 0 0.0000 1.26
GTEx Muscle Skeletal 0 0.0000 1.26
GTEx Nerve Tibial 1 0.0231 1.27
GTEx Ovary 0 0.0000 1.22
GTEx Pancreas 0 0.0000 1.29
GTEx Pituitary 0 0.0000 1.21
GTEx Prostate 0 0.0000 1.37
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.26
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.25
GTEx Small Intestine Terminal Ileum 0 0.0000 1.34
GTEx Spleen 0 0.0000 1.24
GTEx Stomach 0 0.0000 1.25
GTEx Testis 0 0.0000 1.26
GTEx Thyroid 0 0.0000 1.31
GTEx Uterus 0 0.0000 1.14
GTEx Vagina 0 0.0000 1.20
GTEx Whole Blood 0 0.0000 1.18
METSIM Adipose 0 0.0000 1.23
NTR Blood 0 0.0000 1.27
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.34
YFS Blood 0 0.0000 1.22
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.29
TCGA Breast Tumor 0 0.0000 1.27
TCGA Breast Normal 0 0.0000 1.21
TCGA Ovarian Tumor 0 0.0000 1.18
TCGA Prostate Tumor 0 0.0000 1.24