Hub : Traits :

Ever highly irritable/argumentative for 2 days

37 significantly associated models · 8 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 49016056 51043528 8 1 9.7e-09 6.4e-08 0.049 87 RBM6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Irritable Bowel Disease (IBD) 6.6 1 0 0 0 1 RBM6
Ulcerative Colitis (UC) 9.7 1 0 0 0 1 RBM6
Verbal and Numeric Reasoning (VNR) 16.1 1 1 3 0 1 RBM6
Age at First Birth 33.7 1 1 3 0 1 RBM6
Body Mass Index (BMI) (2010) 7.8 1 0 0 0 1 RBM6
Crohns Disease (2012) 6.7 1 0 0 0 1 RBM6
HDL Cholesterol 8.2 1 0 0 0 1 RBM6
Ulcerative Colitis 8.0 1 0 0 0 1 RBM6
Blood Eosinophil Count 3.8 1 1 3 0 1 RBM6
Blood White Count 5.1 1 1 3 0 1 RBM6
Heel T-Score 2.0 1 0 0 0 1 RBM6
BMI 23.4 1 1 3 0 1 RBM6
Smoking Status 4.5 1 0 0 0 1 RBM6
Respiratory disease 9.8 1 0 0 0 1 RBM6
Type 2 Diabetes (T2D) 13.1 1 0 0 0 1 RBM6
Lung FVC 3.3 1 0 0 0 1 RBM6
Neuroticism 12.3 1 1 3 0 1 RBM6
Chronotype (morning person) 6.1 1 0 0 0 1 RBM6
Number of treatments/medications taken 18.8 1 1 3 0 1 RBM6
Frequency of depressed mood in last 2 weeks 7.9 1 0 0 0 1 RBM6
Relative age of first facial hair 10.1 1 0 0 0 1 RBM6
Medication: Co-codamol 17.7 1 0 0 0 1 RBM6
Impedance of leg (right) 6.8 1 1 3 0 1 RBM6
Leg fat-free mass (left) 8.8 1 1 3 0 1 RBM6
Trunk fat percentage 9.1 1 1 3 0 1 RBM6
Fed-up feelings 11.4 1 0 0 0 1 RBM6
Frequency of unenthusiasm / disinterest in last 2 weeks 10.3 1 0 0 0 1 RBM6
Taking other prescription medications 25.7 1 1 3 0 1 RBM6
Bilateral oophorectomy (both ovaries removed) 9.8 1 0 0 0 1 RBM6
Qualifications: CSEs or equivalent 9.7 1 0 0 0 1 RBM6
Chronic bronchitis/emphysema (father) 11.0 1 0 0 0 1 RBM6
Body mass index (BMI) 27.2 1 1 3 0 1 RBM6
Impedance of leg (left) 7.7 1 1 3 0 1 RBM6
Leg predicted mass (left) 8.8 1 1 3 0 1 RBM6
Trunk fat mass 13.4 1 1 3 0 1 RBM6
Waist circumference 17.6 1 1 3 0 1 RBM6
Frequency of tenseness / restlessness in last 2 weeks 10.2 1 0 0 0 1 RBM6
Forced vital capacity (FVC) 2.6 1 0 0 0 1 RBM6
Ever unenthusiastic/disinterested for a whole week 19.6 1 0 0 0 1 RBM6
Qualifications: None of the above 20.6 1 1 3 0 1 RBM6
Diabetes (self-reported) 15.3 1 0 0 0 1 RBM6
Fluid intelligence score 18.5 1 1 3 0 1 RBM6
Illnesses of siblings 7.6 1 0 0 0 1 RBM6
Neuroticism score 14.3 1 1 3 0 1 RBM6
Weight 16.7 1 1 3 0 1 RBM6
Impedance of arm (right) 21.0 1 1 3 0 1 RBM6
Arm fat percentage (right) 15.3 1 1 3 0 1 RBM6
Trunk fat-free mass 7.6 1 1 3 0 1 RBM6
Hip circumference 10.3 1 1 3 0 1 RBM6
Alcohol intake versus 10 years previously 13.6 1 0 0 0 1 RBM6
Hair/balding pattern: Pattern 3 6.8 1 0 0 0 1 RBM6
Number of live births 11.6 1 0 0 0 1 RBM6
Qualifications: A levels/AS levels or equivalent 25.4 1 1 3 0 1 RBM6
Mouth/teeth dental problems: Dentures 10.3 1 0 0 0 1 RBM6
Asthma 8.2 1 0 0 0 1 RBM6
Forced expiratory volume in 1-second (FEV1), Best measure 3.3 1 0 0 0 1 RBM6
Impedance of arm (left) 21.2 1 1 3 0 1 RBM6
Arm fat mass (right) 20.3 1 1 3 0 1 RBM6
Trunk predicted mass 7.5 1 1 3 0 1 RBM6
Exposure to tobacco smoke at home 17.7 1 0 0 0 1 RBM6
Breastfed as a baby 8.8 1 0 0 0 1 RBM6
Seen doctor (GP) for nerves, anxiety, tension or depression 8.9 1 0 0 0 1 RBM6
Medication: Ventolin 100micrograms inhaler 10.7 1 0 0 0 1 RBM6
Chronic bronchitis/emphysema (mother) 14.2 1 0 0 0 1 RBM6
High blood pressure (siblings) 7.5 1 0 0 0 1 RBM6
Forced vital capacity (FVC), Best measure 3.8 1 0 0 0 1 RBM6
Body fat percentage 13.2 1 1 3 0 1 RBM6
Leg fat percentage (right) 21.9 1 1 3 0 1 RBM6
Arm fat-free mass (right) 12.1 1 1 3 0 1 RBM6
Exposure to tobacco smoke outside home 12.5 1 0 0 0 1 RBM6
Wheeze or whistling in the chest in last year 17.2 1 1 3 0 1 RBM6
Age at first live birth 28.7 1 1 3 0 1 RBM6
Health satisfaction 8.4 1 0 0 0 1 RBM6
Qualifications: College or University degree 29.1 1 1 3 0 1 RBM6
Medication: Seretide 50 evohaler 14.0 1 0 0 0 1 RBM6
Whole body fat mass 18.0 1 1 3 0 1 RBM6
Leg fat mass (right) 24.7 1 1 3 0 1 RBM6
Arm predicted mass (right) 13.2 1 1 3 0 1 RBM6
Alcohol intake frequency. 9.8 1 0 0 0 1 RBM6
Comparative height size at age 10 2.0 1 0 0 0 1 RBM6
Number of full sisters 12.5 1 0 0 0 1 RBM6
Overall health rating 22.4 1 1 3 0 1 RBM6
Age at last live birth 35.8 1 1 3 0 1 RBM6
Leg pain on walking 8.9 1 0 0 0 1 RBM6
Qualifications: NVQ or HND or HNC or equivalent 9.6 1 0 0 0 1 RBM6
Knee pain experienced in last month 8.3 1 0 0 0 1 RBM6
Illnesses of siblings: Diabetes 11.2 1 0 0 0 1 RBM6
Whole body fat-free mass 8.9 1 1 3 0 1 RBM6
Leg fat-free mass (right) 7.2 1 1 3 0 1 RBM6
Arm fat percentage (left) 14.9 1 1 3 0 1 RBM6
Average weekly red wine intake 10.6 1 0 0 0 1 RBM6
Mood swings 16.6 1 1 3 0 1 RBM6
Loneliness, isolation 7.8 1 0 0 0 1 RBM6
Long-standing illness, disability or infirmity 7.9 1 0 0 0 1 RBM6
Ever had bowel cancer screening 11.0 1 0 0 0 1 RBM6
Diabetes diagnosed by doctor 12.4 1 0 0 0 1 RBM6
Qualifications: nursing, teaching 7.7 1 0 0 0 1 RBM6
Asthma (self-reported) 8.2 1 0 0 0 1 RBM6
Whole body water mass 9.2 1 1 3 0 1 RBM6
Leg predicted mass (right) 7.0 1 1 3 0 1 RBM6
Arm fat mass (left) 20.2 1 1 3 0 1 RBM6
Number of self-reported non-cancer illnesses 7.3 1 0 0 0 1 RBM6
Miserableness 27.6 1 1 3 0 1 RBM6
Guilty feelings 10.0 1 0 0 0 1 RBM6
Financial situation satisfaction 8.4 1 0 0 0 1 RBM6
Basal metabolic rate 11.3 1 1 3 0 1 RBM6
Leg fat percentage (left) 21.3 1 1 3 0 1 RBM6
Arm fat-free mass (left) 14.3 1 1 3 0 1 RBM6
Number of operations (self-reported) 12.6 1 0 0 0 1 RBM6
Average weekly beer plus cider intake 20.8 1 1 3 0 1 RBM6
Age started oral contraceptive pill 11.9 1 0 0 0 1 RBM6
Diastolic blood pressure, automated reading 6.4 1 0 0 0 1 RBM6
Ever depressed for a whole week 18.9 1 0 0 0 1 RBM6
Pain experienced in last month 9.1 1 0 0 0 1 RBM6
Impedance of whole body 16.1 1 1 3 0 1 RBM6
Leg fat mass (left) 24.7 1 1 3 0 1 RBM6
Arm predicted mass (left) 14.4 1 1 3 0 1 RBM6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.21
GTEx Adipose Visceral Omentum 1 0.0491 1.27
GTEx Adrenal Gland 1 0.0686 1.26
GTEx Artery Aorta 2 0.0672 1.27
GTEx Artery Coronary 0 0.0000 1.23
GTEx Artery Tibial 2 0.0532 1.22
GTEx Brain Caudate basal ganglia 1 0.1087 1.22
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.33
GTEx Brain Cerebellum 3 0.1514 1.23
GTEx Brain Cortex 1 0.0966 1.21
GTEx Brain Frontal Cortex BA9 0 0.0000 1.31
GTEx Brain Hippocampus 0 0.0000 1.24
GTEx Brain Hypothalamus 0 0.0000 1.17
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.14
GTEx Brain Putamen basal ganglia 0 0.0000 1.19
GTEx Breast Mammary Tissue 1 0.0507 1.21
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.21
GTEx Breast Mammary Tissue (Female) 1 0.0608 1.23
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.30
GTEx Cells Transformed fibroblasts 0 0.0000 1.24
GTEx Colon Sigmoid 1 0.0684 1.26
GTEx Colon Transverse 0 0.0000 1.22
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.19
GTEx Esophagus Mucosa 1 0.0301 1.19
GTEx Esophagus Muscularis 2 0.0619 1.26
GTEx Heart Atrial Appendage 1 0.0633 1.25
GTEx Heart Left Ventricle 1 0.0654 1.24
GTEx Liver 1 0.1395 1.16
GTEx Lung 1 0.0348 1.27
GTEx Muscle Skeletal 1 0.0346 1.23
GTEx Nerve Tibial 2 0.0463 1.24
GTEx Ovary 0 0.0000 1.32
GTEx Pancreas 1 0.0613 1.24
GTEx Pituitary 1 0.0897 1.22
GTEx Prostate 1 0.1198 1.22
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.28
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.24
GTEx Small Intestine Terminal Ileum 1 0.2169 1.28
GTEx Spleen 1 0.0709 1.16
GTEx Stomach 0 0.0000 1.18
GTEx Testis 0 0.0000 1.25
GTEx Thyroid 1 0.0250 1.23
GTEx Uterus 0 0.0000 1.41
GTEx Vagina 0 0.0000 1.22
GTEx Whole Blood 1 0.0502 1.20
METSIM Adipose 0 0.0000 1.13
NTR Blood 1 0.0416 1.14
ROSMAP Brain Pre-frontal Cortex 3 0.0683 1.24
YFS Blood 0 0.0000 1.18
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.15
TCGA Breast Tumor 0 0.0000 1.10
TCGA Breast Normal 0 0.0000 1.13
TCGA Ovarian Tumor 0 0.0000 1.12
TCGA Prostate Tumor 0 0.0000 1.15