Hub : Traits :

Heart disease (mother)

5 significantly associated models · 4 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 35908451 37310669 1 1 2.1e-07 2.9e-07 2.0e-01 94 TRAPPC3
2 6 160071844 161571560 1 1 8.7e-10 1.0e-17 8.4e-16 12 SLC22A3
3 9 21303958 22705094 1 1 6.2e-10 1.6e-19 2.4e-11 45 CDKN2B
4 15 78360691 79802863 1 1 3.3e-07 6.6e-07 1.0e+00 100 ADAMTS7

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in mother) 2.99 1 0 0.0 0.00 1.00 ADAMTS7
Major Depression (MDD) 4.05 1 0 0.0 0.00 1.00 TRAPPC3
Breast Cancer 3.16 2 0 0.0 0.00 1.00 CDKN2B TRAPPC3
Coronary Artery Disease (CAD) 25.70 3 1 3.0 0.00 1.00 ADAMTS7 CDKN2B SLC22A3
Primary Biliary Cirrhosis 2.13 1 0 0.0 0.00 1.00 CDKN2B
Schizophrenia 2.57 1 0 0.0 0.00 1.00 TRAPPC3
Type 2 Diabetes (T2D) 4.70 1 0 0.0 0.00 1.00 CDKN2B
Blood Eosinophil Count 0.56 2 0 0.0 0.00 1.00 CDKN2B TRAPPC3
Blood Platelet Count 1.59 4 0 0.0 -0.56 0.44 ADAMTS7 CDKN2B SLC22A3 TRAPPC3
Blood Red Count 0.28 1 0 0.0 0.00 1.00 CDKN2B
Blood White Count 1.02 2 0 0.0 0.00 1.00 CDKN2B TRAPPC3
BMI 1.53 2 0 0.0 0.00 1.00 SLC22A3 TRAPPC3
Height 0.90 2 1 3.0 0.00 1.00 SLC22A3 TRAPPC3
Waist Hip Ratio (WHR) 4.11 1 1 3.0 0.00 1.00 SLC22A3
Systolic Blood Pressure 1.64 2 0 0.0 0.00 1.00 ADAMTS7 SLC22A3
Allergy or Eczema 1.83 1 0 0.0 0.00 1.00 SLC22A3
Cardiovascular Disease 2.05 1 0 0.0 0.00 1.00 SLC22A3
Type 2 Diabetes (T2D) 3.15 2 0 0.0 0.00 1.00 CDKN2B SLC22A3
Hair Pigment 0.64 1 1 3.0 0.00 1.00 CDKN2B
Other serious medical condition/disability diagnosed by doctor 1.75 1 0 0.0 0.00 1.00 TRAPPC3
Systolic blood pressure, automated reading 0.88 1 0 0.0 0.00 1.00 ADAMTS7
Angina 31.29 3 3 9.1 0.00 1.00 ADAMTS7 CDKN2B SLC22A3
Vitamin and mineral supplements 2.71 1 0 0.0 0.00 1.00 ADAMTS7
Medication: Metformin 3.30 1 0 0.0 0.00 1.00 CDKN2B
Pack years adult smoking proportion 13.59 1 1 3.0 0.00 1.00 ADAMTS7
Impedance of leg (right) 2.01 1 1 3.0 0.00 1.00 TRAPPC3
Leg fat-free mass (left) 2.36 2 1 3.0 0.00 1.00 SLC22A3 TRAPPC3
Trunk fat percentage 1.59 1 0 0.0 0.00 1.00 SLC22A3
Bilateral oophorectomy (both ovaries removed) 3.05 1 0 0.0 0.00 1.00 CDKN2B
Qualifications: CSEs or equivalent 1.67 1 0 0.0 0.00 1.00 ADAMTS7
High blood pressure 0.85 1 0 0.0 0.00 1.00 SLC22A3
Hayfever, allergic rhinitis or eczema 2.41 2 0 0.0 0.00 1.00 ADAMTS7 SLC22A3
Multivitamins +/- minerals 3.67 2 0 0.0 0.00 1.00 ADAMTS7 SLC22A3
Medication: Atenolol 5.03 2 0 0.0 0.00 1.00 ADAMTS7 CDKN2B
Sitting height 1.48 2 0 0.0 0.00 1.00 ADAMTS7 SLC22A3
Chronic bronchitis/emphysema (father) 4.65 2 0 0.0 0.00 1.00 ADAMTS7 SLC22A3
Body mass index (BMI) 0.89 1 0 0.0 0.00 1.00 TRAPPC3
Impedance of leg (left) 1.73 1 1 3.0 0.00 1.00 TRAPPC3
Leg predicted mass (left) 2.38 2 1 3.0 0.00 1.00 SLC22A3 TRAPPC3
Trunk fat mass 1.94 1 0 0.0 0.00 1.00 SLC22A3
Waist circumference 0.78 1 0 0.0 0.00 1.00 TRAPPC3
Heel bone mineral density (BMD) T-score, automated (right) 0.99 1 0 0.0 0.00 1.00 CDKN2B
Mouth/teeth dental problems 1.81 1 0 0.0 0.00 1.00 CDKN2B
Heart attack 21.53 3 2 6.1 0.00 1.00 ADAMTS7 CDKN2B SLC22A3
Pain all over the body in last month 3.54 1 0 0.0 0.00 1.00 TRAPPC3
Diabetes (self-reported) 1.92 1 0 0.0 0.00 1.00 SLC22A3
Medication: Ramipril 4.07 1 0 0.0 0.00 1.00 SLC22A3
Medication: Simvastatin 5.45 2 0 0.0 0.00 1.00 CDKN2B SLC22A3
Illnesses of siblings 2.22 1 0 0.0 0.00 1.00 SLC22A3
Weight 2.04 2 0 0.0 0.00 1.00 SLC22A3 TRAPPC3
Impedance of arm (right) 0.92 1 0 0.0 0.00 1.00 CDKN2B
Arm fat percentage (right) 1.34 1 0 0.0 0.00 1.00 SLC22A3
Trunk fat-free mass 1.89 2 1 3.0 0.00 1.00 SLC22A3 TRAPPC3
Hip circumference 2.59 2 1 3.0 0.00 1.00 SLC22A3 TRAPPC3
Father's age at death 4.26 1 0 0.0 0.00 1.00 CDKN2B
Frequency of tiredness / lethargy in last 2 weeks 1.98 1 0 0.0 0.00 1.00 TRAPPC3
Mouth/teeth dental problems: Dentures 1.98 1 0 0.0 0.00 1.00 CDKN2B
Medication: Ibuprofen (e.g. Nurofen) 2.95 1 0 0.0 0.00 1.00 SLC22A3
Medication: Cholesterol lowering 6.98 2 0 0.0 0.00 1.00 CDKN2B SLC22A3
Medication: Lansoprazole 3.01 1 0 0.0 0.00 1.00 SLC22A3
Lung cancer (father) 6.25 1 0 0.0 0.00 1.00 ADAMTS7
Illnesses of mother 4.90 2 0 0.0 0.00 1.00 CDKN2B TRAPPC3
Pulse wave Arterial Stiffness index 2.26 1 0 0.0 0.00 1.00 CDKN2B
Impedance of arm (left) 0.82 2 0 0.0 0.00 1.00 CDKN2B TRAPPC3
Arm fat mass (right) 1.71 2 0 0.0 0.00 1.00 SLC22A3 TRAPPC3
Trunk predicted mass 1.87 2 1 3.0 0.00 1.00 SLC22A3 TRAPPC3
Standing height 1.08 2 1 3.0 0.00 1.00 SLC22A3 TRAPPC3
Length of working week for main job 2.11 1 0 0.0 0.00 1.00 ADAMTS7
Pulse wave reflection index 2.56 1 0 0.0 0.00 1.00 SLC22A3
Headache pain in last month 1.37 1 0 0.0 0.00 1.00 SLC22A3
Medication for cholesterol, blood pressure or diabetes 2.52 1 0 0.0 0.00 1.00 TRAPPC3
Glaucoma (self-reported) 11.36 1 1 3.0 0.00 1.00 CDKN2B
Chronic bronchitis/emphysema (mother) 4.74 1 0 0.0 0.00 1.00 ADAMTS7
Body fat percentage 1.31 1 0 0.0 0.00 1.00 SLC22A3
Arm fat-free mass (right) 1.50 2 0 0.0 0.00 1.00 SLC22A3 TRAPPC3
Pulse wave peak to peak time 2.22 1 0 0.0 0.00 1.00 CDKN2B
Shortness of breath walking on level ground 2.34 1 0 0.0 0.00 1.00 TRAPPC3
Qualifications: College or University degree 0.79 1 0 0.0 0.00 1.00 TRAPPC3
Medication for pain relief, constipation, heartburn 2.53 1 0 0.0 0.00 1.00 TRAPPC3
Angina (self-reported) 32.08 3 3 9.1 0.00 1.00 ADAMTS7 CDKN2B SLC22A3
Medication: Ibuprofen 3.64 1 0 0.0 0.00 1.00 SLC22A3
Whole body fat mass 1.92 2 0 0.0 0.00 1.00 SLC22A3 TRAPPC3
Leg fat mass (right) 1.23 1 0 0.0 0.00 1.00 SLC22A3
Arm predicted mass (right) 1.47 2 0 0.0 0.00 1.00 SLC22A3 TRAPPC3
Comparative height size at age 10 1.58 2 0 0.0 0.00 1.00 SLC22A3 TRAPPC3
Chest pain or discomfort 3.67 1 0 0.0 0.00 1.00 CDKN2B
Qualifications: NVQ or HND or HNC or equivalent 2.06 1 0 0.0 0.00 1.00 ADAMTS7
Medication: Aspirin 15.57 2 2 6.1 0.00 1.00 CDKN2B SLC22A3
Hypertension (Self-reported) 1.09 1 0 0.0 0.00 1.00 SLC22A3
Illnesses of father: Heart disease 29.24 3 2 6.1 0.00 1.00 ADAMTS7 CDKN2B SLC22A3
Smoking status: Previous 1.41 1 0 0.0 0.00 1.00 CDKN2B
Whole body fat-free mass 2.13 2 1 3.0 0.00 1.00 SLC22A3 TRAPPC3
Leg fat-free mass (right) 2.49 2 1 3.0 0.00 1.00 SLC22A3 TRAPPC3
Arm fat percentage (left) 1.07 1 0 0.0 0.00 1.00 SLC22A3
Average weekly red wine intake 2.63 1 0 0.0 0.00 1.00 SLC22A3
Long-standing illness, disability or infirmity 4.36 2 0 0.0 0.00 1.00 CDKN2B TRAPPC3
Diabetes diagnosed by doctor 3.22 1 0 0.0 0.00 1.00 SLC22A3
Medication for cholesterol 6.39 2 1 3.0 0.00 1.00 CDKN2B SLC22A3
Back pain experienced in last month 1.50 1 0 0.0 0.00 1.00 ADAMTS7
Mineral and other dietary supplements 2.90 1 0 0.0 0.00 1.00 SLC22A3
Breast cancer (self-reported) 3.06 1 0 0.0 0.00 1.00 CDKN2B
Osteoporosis (self-reported) 2.32 1 0 0.0 0.00 1.00 SLC22A3
Medication: Aspirin 14.95 2 2 6.1 0.00 1.00 CDKN2B SLC22A3
Medication: Gliclazide 3.26 1 0 0.0 0.00 1.00 CDKN2B
Illnesses of father: None of the above (group 1) 10.49 2 1 3.0 0.00 1.00 CDKN2B SLC22A3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.65 1 0 0.0 0.00 1.00 ADAMTS7
Whole body water mass 2.04 2 1 3.0 0.00 1.00 SLC22A3 TRAPPC3
Leg predicted mass (right) 2.48 2 1 3.0 0.00 1.00 SLC22A3 TRAPPC3
Arm fat mass (left) 1.70 2 0 0.0 0.00 1.00 SLC22A3 TRAPPC3
Number of self-reported non-cancer illnesses 3.07 1 0 0.0 0.00 1.00 SLC22A3
Ever taken oral contraceptive pill 2.60 1 0 0.0 0.00 1.00 TRAPPC3
Eye problems/disorders: Glaucoma 15.13 1 1 3.0 0.00 1.00 CDKN2B
Medication: Blood pressure 3.42 1 0 0.0 0.00 1.00 SLC22A3
Supplements: Fish oil (including cod liver oil) 2.59 1 0 0.0 0.00 1.00 SLC22A3
High cholesterol (Self-reported) 8.39 2 1 3.0 0.00 1.00 CDKN2B SLC22A3
Medication: Atorvastatin 11.64 2 1 3.0 0.00 1.00 CDKN2B SLC22A3
Basal metabolic rate 2.21 2 1 3.0 0.00 1.00 SLC22A3 TRAPPC3
Arm fat-free mass (left) 1.59 2 0 0.0 0.00 1.00 SLC22A3 TRAPPC3
Number of operations (self-reported) 1.97 1 0 0.0 0.00 1.00 CDKN2B
Diastolic blood pressure, automated reading 2.84 3 0 0.0 0.00 1.00 ADAMTS7 CDKN2B SLC22A3
Vascular/heart problems diagnosed by doctor 2.49 2 0 0.0 0.00 1.00 CDKN2B SLC22A3
Cholesterol lowering medication 9.50 2 1 3.0 0.00 1.00 CDKN2B SLC22A3
Basal cell carcinoma (self-reported) 5.44 1 0 0.0 0.00 1.00 CDKN2B
Heart attack/myocardial infarction (self-reported) 21.74 3 2 6.1 0.00 1.00 ADAMTS7 CDKN2B SLC22A3
Heart disease (siblings) 8.92 3 0 0.0 0.00 1.00 ADAMTS7 CDKN2B SLC22A3
Pack years of smoking 11.50 1 1 3.0 0.00 1.00 ADAMTS7
Impedance of whole body 1.47 2 0 0.0 0.00 1.00 CDKN2B TRAPPC3
Leg fat mass (left) 1.26 1 0 0.0 0.00 1.00 SLC22A3
Arm predicted mass (left) 1.69 2 0 0.0 0.00 1.00 SLC22A3 TRAPPC3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.24
GTEx Adipose Visceral Omentum 0 0.0000 1.25
GTEx Adrenal Gland 0 0.0000 1.28
GTEx Artery Aorta 0 0.0000 1.31
GTEx Artery Coronary 0 0.0000 1.33
GTEx Artery Tibial 1 0.0266 1.25
GTEx Brain Caudate basal ganglia 0 0.0000 1.19
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.19
GTEx Brain Cerebellum 0 0.0000 1.22
GTEx Brain Cortex 0 0.0000 1.20
GTEx Brain Frontal Cortex BA9 0 0.0000 1.29
GTEx Brain Hippocampus 0 0.0000 1.22
GTEx Brain Hypothalamus 0 0.0000 1.23
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.24
GTEx Brain Putamen basal ganglia 0 0.0000 1.23
GTEx Breast Mammary Tissue 0 0.0000 1.26
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.19
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.23
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.26
GTEx Cells Transformed fibroblasts 0 0.0000 1.23
GTEx Colon Sigmoid 0 0.0000 1.32
GTEx Colon Transverse 0 0.0000 1.32
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.27
GTEx Esophagus Mucosa 0 0.0000 1.27
GTEx Esophagus Muscularis 0 0.0000 1.22
GTEx Heart Atrial Appendage 0 0.0000 1.23
GTEx Heart Left Ventricle 0 0.0000 1.29
GTEx Liver 0 0.0000 1.27
GTEx Lung 0 0.0000 1.25
GTEx Muscle Skeletal 0 0.0000 1.21
GTEx Nerve Tibial 0 0.0000 1.19
GTEx Ovary 0 0.0000 1.34
GTEx Pancreas 0 0.0000 1.29
GTEx Pituitary 0 0.0000 1.22
GTEx Prostate 0 0.0000 1.34
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.29
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.25
GTEx Small Intestine Terminal Ileum 0 0.0000 1.26
GTEx Spleen 0 0.0000 1.23
GTEx Stomach 0 0.0000 1.28
GTEx Testis 0 0.0000 1.26
GTEx Thyroid 1 0.0250 1.24
GTEx Uterus 0 0.0000 1.36
GTEx Vagina 0 0.0000 1.21
GTEx Whole Blood 0 0.0000 1.23
METSIM Adipose 0 0.0000 1.18
NTR Blood 0 0.0000 1.19
ROSMAP Brain Pre-frontal Cortex 1 0.0228 1.21
YFS Blood 0 0.0000 1.17
CommonMind Brain Pre-frontal Cortex 2 0.0372 1.23
TCGA Breast Tumor 0 0.0000 1.17
TCGA Breast Normal 0 0.0000 1.18
TCGA Ovarian Tumor 0 0.0000 1.16
TCGA Prostate Tumor 0 0.0000 1.20