Hub : Traits :

Major Depression (MDD)

4 significantly associated models · 4 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 23321966 24719691 1 1 7.0e-08 3.9e-04 0.011 48 RPL11
2 1 71163715 73435171 1 1 6.4e-08 2.2e-08 0.045 87 NEGR1
3 8 94054300 95450289 1 1 3.5e-07 4.9e-06 0.449 97 RP11-10N23.5
4 11 56742853 58166421 1 1 3.9e-07 1.9e-06 0.491 98 ZDHHC5

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Verbal and Numeric Reasoning (VNR) 9.75 2 1 3.0 0 1 NEGR1 ZDHHC5
Breast Cancer 3.11 3 0 0.0 0 1 NEGR1 RP11-10N23.5 ZDHHC5
Body Mass Index (BMI) (2010) 10.38 1 1 3.0 0 1 NEGR1
Neuroticism 2.44 1 0 0.0 0 1 ZDHHC5
Schizophrenia 3.08 1 0 0.0 0 1 ZDHHC5
Triglycerides 1.30 1 0 0.0 0 1 NEGR1
Blood Eosinophil Count 0.71 1 0 0.0 0 1 ZDHHC5
Blood Platelet Count 2.12 1 1 3.0 0 1 ZDHHC5
Blood Red Count 1.03 2 0 0.0 0 1 RPL11 ZDHHC5
Blood White Count 0.70 1 0 0.0 0 1 RPL11
Heel T-Score 1.94 2 2 6.1 0 1 NEGR1 ZDHHC5
BMI 5.83 2 1 3.0 0 1 NEGR1 ZDHHC5
Height 0.56 2 1 3.0 0 1 RPL11 ZDHHC5
Waist Hip Ratio (WHR) 1.32 1 0 0.0 0 1 RPL11
Systolic Blood Pressure 2.75 2 1 3.0 0 1 NEGR1 ZDHHC5
Allergy or Eczema 2.62 1 0 0.0 0 1 NEGR1
Cardiovascular Disease 2.40 1 1 3.0 0 1 NEGR1
Respiratory disease 2.33 1 0 0.0 0 1 NEGR1
Lung FEV1/FVC ratio 3.60 2 2 6.1 0 1 NEGR1 ZDHHC5
Lung FVC 0.34 1 0 0.0 0 1 RPL11
Neuroticism 5.37 2 1 3.0 0 1 RP11-10N23.5 ZDHHC5
Chronotype (morning person) 2.37 1 0 0.0 0 1 ZDHHC5
Hair Pigment 0.07 1 0 0.0 0 1 NEGR1
Tanning 0.49 2 0 0.0 0 1 NEGR1 ZDHHC5
Hand grip strength (left) 1.72 1 0 0.0 0 1 ZDHHC5
Number of treatments/medications taken 2.73 1 0 0.0 0 1 NEGR1
Average weekly spirits intake 1.91 1 0 0.0 0 1 NEGR1
Sensitivity / hurt feelings 4.59 3 0 0.0 0 1 NEGR1 RP11-10N23.5 ZDHHC5
Frequency of depressed mood in last 2 weeks 5.03 1 0 0.0 0 1 ZDHHC5
Hearing difficulty/problems: Yes 1.99 1 0 0.0 0 1 ZDHHC5
Relative age of first facial hair 2.16 1 0 0.0 0 1 NEGR1
Other serious medical condition/disability diagnosed by doctor 3.28 1 0 0.0 0 1 NEGR1
Systolic blood pressure, automated reading 1.94 1 0 0.0 0 1 ZDHHC5
Vitamin and mineral supplements 3.12 1 0 0.0 0 1 NEGR1
Supplements: Zinc 2.51 1 0 0.0 0 1 NEGR1
Severe depression (siblings) 3.13 1 0 0.0 0 1 NEGR1
Pack years adult smoking proportion 1.91 1 0 0.0 0 1 ZDHHC5
Impedance of leg (right) 1.47 1 0 0.0 0 1 NEGR1
Leg fat-free mass (left) 2.02 1 1 3.0 0 1 NEGR1
Trunk fat percentage 3.46 2 1 3.0 0 1 NEGR1 ZDHHC5
Hand grip strength (right) 1.41 1 0 0.0 0 1 ZDHHC5
Townsend deprivation index at recruitment 3.25 1 0 0.0 0 1 ZDHHC5
Current tobacco smoking 3.19 2 0 0.0 0 1 NEGR1 ZDHHC5
Fed-up feelings 4.27 1 0 0.0 0 1 ZDHHC5
Frequency of unenthusiasm / disinterest in last 2 weeks 5.44 1 0 0.0 0 1 ZDHHC5
Relative age voice broke 2.53 2 0 0.0 0 1 NEGR1 RPL11
Taking other prescription medications 3.11 1 0 0.0 0 1 NEGR1
Age when periods started (menarche) 6.27 1 1 3.0 0 1 NEGR1
Qualifications: CSEs or equivalent 3.85 1 0 0.0 0 1 ZDHHC5
High blood pressure 2.73 1 0 0.0 0 1 NEGR1
Hayfever, allergic rhinitis or eczema 2.26 1 0 0.0 0 1 NEGR1
Multivitamins +/- minerals 3.62 1 0 0.0 0 1 NEGR1
Stomach or abdominal pain in last month 4.66 2 0 0.0 0 1 NEGR1 RP11-10N23.5
Sitting height 1.55 1 1 3.0 0 1 ZDHHC5
Body mass index (BMI) 4.44 1 1 3.0 0 1 NEGR1
Impedance of leg (left) 1.45 1 0 0.0 0 1 NEGR1
Leg predicted mass (left) 1.99 1 1 3.0 0 1 NEGR1
Trunk fat mass 3.40 2 1 3.0 0 1 NEGR1 ZDHHC5
Waist circumference 3.39 1 1 3.0 0 1 NEGR1
Number of incorrect matches in round 1.06 1 0 0.0 0 1 NEGR1
Alcohol usually taken with meals 7.88 2 1 3.0 0 1 NEGR1 ZDHHC5
Frequency of tenseness / restlessness in last 2 weeks 2.48 1 0 0.0 0 1 ZDHHC5
Hearing difficulty/problems with background noise 1.46 1 0 0.0 0 1 RP11-10N23.5
Hair/balding pattern: Pattern 2 1.97 1 0 0.0 0 1 ZDHHC5
Forced vital capacity (FVC) 1.49 1 0 0.0 0 1 RPL11
Ever unenthusiastic/disinterested for a whole week 2.20 1 0 0.0 0 1 ZDHHC5
Qualifications: None of the above 7.10 2 1 3.0 0 1 NEGR1 ZDHHC5
Financial difficulties in last 2 years 2.31 1 0 0.0 0 1 ZDHHC5
Mouth/teeth dental problems 3.57 2 0 0.0 0 1 NEGR1 ZDHHC5
Allergy 2.05 1 0 0.0 0 1 NEGR1
Pain all over the body in last month 2.06 1 0 0.0 0 1 ZDHHC5
Fluid intelligence score 6.49 2 1 3.0 0 1 NEGR1 ZDHHC5
Neuroticism score 5.20 1 1 3.0 0 1 ZDHHC5
Weight 3.16 1 1 3.0 0 1 NEGR1
Impedance of arm (right) 2.89 2 1 3.0 0 1 NEGR1 ZDHHC5
Arm fat percentage (right) 4.68 2 1 3.0 0 1 NEGR1 ZDHHC5
Trunk fat-free mass 1.93 3 0 0.0 0 1 NEGR1 RP11-10N23.5 ZDHHC5
Hip circumference 4.11 2 1 3.0 0 1 NEGR1 RP11-10N23.5
Alcohol intake versus 10 years previously 4.41 1 0 0.0 0 1 NEGR1
Worrier / anxious feelings 4.49 1 1 3.0 0 1 ZDHHC5
Frequency of tiredness / lethargy in last 2 weeks 4.78 1 1 3.0 0 1 ZDHHC5
Falls in the last year 3.05 1 0 0.0 0 1 NEGR1
Forced expiratory volume in 1-second (FEV1) 2.45 2 0 0.0 0 1 RPL11 ZDHHC5
Qualifications: A levels/AS levels or equivalent 4.36 2 1 3.0 0 1 NEGR1 ZDHHC5
Mouth/teeth dental problems: Dentures 2.88 1 0 0.0 0 1 NEGR1
Asthma 1.51 1 0 0.0 0 1 NEGR1
Depression (self-reported) 2.41 1 0 0.0 0 1 ZDHHC5
Medication: Lansoprazole 2.06 1 0 0.0 0 1 RP11-10N23.5
Prospective memory result 2.44 1 0 0.0 0 1 ZDHHC5
Illnesses of mother 1.80 1 0 0.0 0 1 RP11-10N23.5
Forced expiratory volume in 1-second (FEV1), Best measure 2.13 2 0 0.0 0 1 RPL11 ZDHHC5
Impedance of arm (left) 2.32 2 1 3.0 0 1 NEGR1 ZDHHC5
Arm fat mass (right) 4.42 2 1 3.0 0 1 NEGR1 ZDHHC5
Trunk predicted mass 1.98 3 0 0.0 0 1 NEGR1 RP11-10N23.5 ZDHHC5
Standing height 0.87 2 0 0.0 0 1 RPL11 ZDHHC5
Tense / 'highly strung' 2.45 1 0 0.0 0 1 ZDHHC5
Seen doctor (GP) for nerves, anxiety, tension or depression 10.49 3 1 3.0 0 1 NEGR1 RP11-10N23.5 ZDHHC5
Peak expiratory flow (PEF) 1.99 1 0 0.0 0 1 ZDHHC5
Loud music exposure frequency 3.33 1 0 0.0 0 1 RPL11
Qualifications: O levels/GCSEs or equivalent 2.04 1 0 0.0 0 1 ZDHHC5
Mouth/teeth dental problems: Bleeding gums 1.67 1 0 0.0 0 1 NEGR1
Headache pain in last month 2.08 1 0 0.0 0 1 ZDHHC5
Medication for cholesterol, blood pressure or diabetes 2.08 1 0 0.0 0 1 NEGR1
Birth weight 0.80 1 0 0.0 0 1 RP11-10N23.5
Forced vital capacity (FVC), Best measure 1.21 1 0 0.0 0 1 RPL11
Body fat percentage 4.38 2 1 3.0 0 1 NEGR1 ZDHHC5
Leg fat percentage (right) 4.51 2 1 3.0 0 1 NEGR1 ZDHHC5
Arm fat-free mass (right) 2.67 2 1 3.0 0 1 NEGR1 ZDHHC5
Comparative body size at age 10 10.51 1 1 3.0 0 1 NEGR1
Worry too long after embarrassment 5.90 1 1 3.0 0 1 ZDHHC5
Seen a psychiatrist for nerves, anxiety, tension or depression 5.20 2 0 0.0 0 1 NEGR1 RPL11
Qualifications: College or University degree 9.51 2 1 3.0 0 1 NEGR1 ZDHHC5
Medication: Blood pressure 1.81 1 0 0.0 0 1 NEGR1
Medication: Seretide 50 evohaler 1.94 1 0 0.0 0 1 ZDHHC5
Whole body fat mass 4.10 1 1 3.0 0 1 NEGR1
Leg fat mass (right) 4.69 1 1 3.0 0 1 NEGR1
Arm predicted mass (right) 2.63 2 1 3.0 0 1 NEGR1 ZDHHC5
Pulse rate, automated reading 4.90 2 2 6.1 0 1 NEGR1 ZDHHC5
Alcohol intake frequency. 4.46 2 0 0.0 0 1 NEGR1 ZDHHC5
Comparative height size at age 10 0.83 2 0 0.0 0 1 NEGR1 RPL11
Number of full sisters 2.23 1 0 0.0 0 1 RP11-10N23.5
Overall health rating 3.08 1 0 0.0 0 1 ZDHHC5
Commuting to job workplace: Car/motor vehicle 5.28 1 0 0.0 0 1 NEGR1
Hypertension (Self-reported) 2.27 1 0 0.0 0 1 NEGR1
Illnesses of father: Heart disease 1.75 1 0 0.0 0 1 NEGR1
Smoking status: Previous 1.89 1 0 0.0 0 1 NEGR1
Whole body fat-free mass 1.97 2 1 3.0 0 1 NEGR1 ZDHHC5
Leg fat-free mass (right) 1.82 1 1 3.0 0 1 NEGR1
Arm fat percentage (left) 4.87 2 1 3.0 0 1 NEGR1 ZDHHC5
Average weekly red wine intake 9.05 2 1 3.0 0 1 NEGR1 ZDHHC5
Mood swings 2.03 1 0 0.0 0 1 ZDHHC5
Loneliness, isolation 3.11 1 0 0.0 0 1 ZDHHC5
Long-standing illness, disability or infirmity 5.33 2 0 0.0 0 1 NEGR1 RP11-10N23.5
Friendships satisfaction 2.07 1 0 0.0 0 1 NEGR1
Qualifications: nursing, teaching 8.66 2 1 3.0 0 1 NEGR1 ZDHHC5
Commuting to job workplace: Walk 2.61 1 0 0.0 0 1 NEGR1
Mineral and other dietary supplements 2.75 1 0 0.0 0 1 ZDHHC5
Asthma (self-reported) 1.54 1 0 0.0 0 1 NEGR1
Osteoarthritis (self-reported) 2.30 1 0 0.0 0 1 NEGR1
Illnesses of father: None of the above (group 1) 1.68 1 0 0.0 0 1 NEGR1
Smoking status: Current 3.09 2 0 0.0 0 1 NEGR1 ZDHHC5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.65 1 0 0.0 0 1 ZDHHC5
Whole body water mass 2.01 3 1 3.0 0 1 NEGR1 RP11-10N23.5 ZDHHC5
Leg predicted mass (right) 1.83 1 1 3.0 0 1 NEGR1
Arm fat mass (left) 4.49 2 1 3.0 0 1 NEGR1 ZDHHC5
Number of self-reported non-cancer illnesses 4.68 1 1 3.0 0 1 NEGR1
Guilty feelings 5.61 1 1 3.0 0 1 ZDHHC5
Wears glasses or contact lenses 2.86 1 0 0.0 0 1 ZDHHC5
Commuting to job workplace: Public transport 4.61 1 0 0.0 0 1 NEGR1
Supplements: Fish oil (including cod liver oil) 1.80 1 0 0.0 0 1 ZDHHC5
Medication: Paracetamol 1.48 1 0 0.0 0 1 ZDHHC5
Basal metabolic rate 2.15 1 1 3.0 0 1 NEGR1
Leg fat percentage (left) 4.61 2 1 3.0 0 1 NEGR1 ZDHHC5
Arm fat-free mass (left) 2.52 2 1 3.0 0 1 NEGR1 ZDHHC5
Number of operations (self-reported) 3.89 1 0 0.0 0 1 NEGR1
Average weekly beer plus cider intake 2.82 1 0 0.0 0 1 NEGR1
Irritability 2.49 1 0 0.0 0 1 ZDHHC5
Ever had prostate specific antigen (PSA) test 2.60 1 0 0.0 0 1 NEGR1
Unable to work because of sickness or disability 3.83 1 0 0.0 0 1 ZDHHC5
Commuting to job workplace: Cycle 4.93 2 0 0.0 0 1 NEGR1 ZDHHC5
Vascular/heart problems diagnosed by doctor 2.05 1 0 0.0 0 1 NEGR1
Pain experienced in last month 2.77 1 0 0.0 0 1 ZDHHC5
Alcohol drinker status: Previous 3.26 1 0 0.0 0 1 ZDHHC5
Pack years of smoking 1.87 1 0 0.0 0 1 ZDHHC5
Impedance of whole body 1.96 2 1 3.0 0 1 NEGR1 ZDHHC5
Leg fat mass (left) 4.82 1 1 3.0 0 1 NEGR1
Arm predicted mass (left) 2.43 2 1 3.0 0 1 NEGR1 ZDHHC5

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.38
GTEx Adipose Visceral Omentum 0 0.0000 1.44
GTEx Adrenal Gland 0 0.0000 1.32
GTEx Artery Aorta 0 0.0000 1.33
GTEx Artery Coronary 0 0.0000 1.48
GTEx Artery Tibial 0 0.0000 1.39
GTEx Brain Caudate basal ganglia 0 0.0000 1.42
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.32
GTEx Brain Cerebellum 0 0.0000 1.39
GTEx Brain Cortex 0 0.0000 1.36
GTEx Brain Frontal Cortex BA9 0 0.0000 1.37
GTEx Brain Hippocampus 0 0.0000 1.38
GTEx Brain Hypothalamus 0 0.0000 1.35
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.40
GTEx Brain Putamen basal ganglia 0 0.0000 1.22
GTEx Breast Mammary Tissue 0 0.0000 1.43
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.24
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.44
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.44
GTEx Cells Transformed fibroblasts 0 0.0000 1.35
GTEx Colon Sigmoid 0 0.0000 1.45
GTEx Colon Transverse 0 0.0000 1.40
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.35
GTEx Esophagus Mucosa 0 0.0000 1.31
GTEx Esophagus Muscularis 0 0.0000 1.39
GTEx Heart Atrial Appendage 0 0.0000 1.41
GTEx Heart Left Ventricle 0 0.0000 1.41
GTEx Liver 0 0.0000 1.38
GTEx Lung 0 0.0000 1.35
GTEx Muscle Skeletal 0 0.0000 1.35
GTEx Nerve Tibial 0 0.0000 1.35
GTEx Ovary 0 0.0000 1.40
GTEx Pancreas 0 0.0000 1.33
GTEx Pituitary 0 0.0000 1.37
GTEx Prostate 0 0.0000 1.45
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.45
GTEx Skin Sun Exposed Lower leg 1 0.0309 1.37
GTEx Small Intestine Terminal Ileum 0 0.0000 1.57
GTEx Spleen 0 0.0000 1.55
GTEx Stomach 0 0.0000 1.35
GTEx Testis 0 0.0000 1.40
GTEx Thyroid 0 0.0000 1.45
GTEx Uterus 0 0.0000 1.35
GTEx Vagina 0 0.0000 1.32
GTEx Whole Blood 0 0.0000 1.42
METSIM Adipose 0 0.0000 1.35
NTR Blood 0 0.0000 1.35
ROSMAP Brain Pre-frontal Cortex 1 0.0252 1.38
YFS Blood 0 0.0000 1.35
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.40
TCGA Breast Tumor 0 0.0000 1.37
TCGA Breast Normal 1 0.0260 1.26
TCGA Ovarian Tumor 1 0.0367 1.32
TCGA Prostate Tumor 0 0.0000 1.34