Hub : Traits :

Exposure to tobacco smoke outside home

4 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 242590540 244345666 2 2 7.2e-09 1.9e-08 0.013 80 CEP170 SDCCAG8
2 7 116660803 118207833 1 1 1.7e-07 1.7e-07 0.075 88 CTTNBP2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Major Depression (MDD) 3.71 1 0 0 0 1 CTTNBP2
Reaction Time 3.20 2 0 0 0 1 CEP170 SDCCAG8
Breast Cancer 1.62 1 0 0 0 1 SDCCAG8
Bipolar Disorder 3.31 1 0 0 0 1 CTTNBP2
Neuroticism 2.91 1 0 0 0 1 CTTNBP2
Rheumatoid Arthritis 4.65 1 0 0 0 1 CEP170
Type 2 Diabetes (T2D) 3.16 1 0 0 0 1 CTTNBP2
Blood Platelet Count 0.45 1 0 0 0 1 CTTNBP2
Blood Red Count 0.64 2 0 0 0 1 CEP170 SDCCAG8
Blood White Count 1.53 2 0 0 0 1 CTTNBP2 SDCCAG8
Heel T-Score 0.46 1 0 0 0 1 CTTNBP2
BMI 0.66 1 0 0 0 1 CEP170
Height 0.38 1 0 0 0 1 CTTNBP2
Waist Hip Ratio (WHR) 1.01 1 0 0 0 1 CTTNBP2
Systolic Blood Pressure 1.27 1 0 0 0 1 SDCCAG8
Smoking Status 7.68 1 1 3 0 1 CTTNBP2
Cardiovascular Disease 1.96 1 0 0 0 1 SDCCAG8
Type 2 Diabetes (T2D) 2.66 1 0 0 0 1 CTTNBP2
Lung FEV1/FVC ratio 1.17 1 0 0 0 1 CTTNBP2
Lung FVC 1.17 1 0 0 0 1 CTTNBP2
Neuroticism 2.71 1 0 0 0 1 CTTNBP2
Chronotype (morning person) 3.57 2 0 0 0 1 CTTNBP2 SDCCAG8
Number of treatments/medications taken 4.42 2 0 0 0 1 CEP170 SDCCAG8
Sensitivity / hurt feelings 2.32 1 0 0 0 1 CTTNBP2
Frequency of depressed mood in last 2 weeks 3.85 1 0 0 0 1 CTTNBP2
Hearing difficulty/problems: Yes 2.77 1 0 0 0 1 CEP170
Medication: Co-codamol 2.78 1 0 0 0 1 SDCCAG8
Medication: Metformin 3.93 1 0 0 0 1 CTTNBP2
Diabetes (mother) 1.86 1 0 0 0 1 CTTNBP2
Trunk fat percentage 1.14 1 0 0 0 1 CEP170
Townsend deprivation index at recruitment 6.02 1 0 0 0 1 CTTNBP2
Current tobacco smoking 6.27 1 0 0 0 1 CTTNBP2
Average weekly fortified wine intake 2.13 1 0 0 0 1 CTTNBP2
Maternal smoking around birth 2.41 1 0 0 0 1 CTTNBP2
Fed-up feelings 6.05 1 1 3 0 1 CTTNBP2
Frequency of unenthusiasm / disinterest in last 2 weeks 5.22 1 0 0 0 1 CTTNBP2
Taking other prescription medications 3.86 2 0 0 0 1 CEP170 SDCCAG8
Age when periods started (menarche) 1.75 1 0 0 0 1 SDCCAG8
Tinnitus: Yes, but not now, but have in the past 2.11 1 0 0 0 1 CEP170
Serious illness, injury or assault to yourself 2.65 1 0 0 0 1 CTTNBP2
High blood pressure 1.95 1 0 0 0 1 SDCCAG8
Sitting height 1.14 2 0 0 0 1 CTTNBP2 SDCCAG8
Body mass index (BMI) 1.16 1 0 0 0 1 CEP170
Trunk fat mass 0.95 1 0 0 0 1 CEP170
Waist circumference 1.50 2 0 0 0 1 CEP170 SDCCAG8
Number of incorrect matches in round 3.70 2 0 0 0 1 CTTNBP2 SDCCAG8
Past tobacco smoking 3.31 1 0 0 0 1 CTTNBP2
Alcohol usually taken with meals 6.65 1 1 3 0 1 CTTNBP2
Nervous feelings 1.18 1 0 0 0 1 CTTNBP2
Qualifications: None of the above 5.93 3 0 0 0 1 CEP170 CTTNBP2 SDCCAG8
Financial difficulties in last 2 years 8.28 3 0 0 0 1 CEP170 CTTNBP2 SDCCAG8
Mouth/teeth dental problems 6.04 1 0 0 0 1 SDCCAG8
Diabetes (self-reported) 3.18 1 0 0 0 1 CTTNBP2
Illnesses of siblings 3.31 1 0 0 0 1 SDCCAG8
Neuroticism score 3.50 1 0 0 0 1 CTTNBP2
Arm fat percentage (right) 1.54 1 0 0 0 1 CEP170
Alcohol intake versus 10 years previously 4.82 2 0 0 0 1 CTTNBP2 SDCCAG8
Father's age at death 2.98 1 0 0 0 1 CTTNBP2
Worrier / anxious feelings 1.89 1 0 0 0 1 CTTNBP2
Frequency of tiredness / lethargy in last 2 weeks 3.12 1 0 0 0 1 CTTNBP2
Falls in the last year 4.08 2 0 0 0 1 CTTNBP2 SDCCAG8
Forced expiratory volume in 1-second (FEV1) 1.14 1 0 0 0 1 CTTNBP2
Qualifications: A levels/AS levels or equivalent 6.23 2 0 0 0 1 CTTNBP2 SDCCAG8
Mouth/teeth dental problems: Dentures 4.38 2 0 0 0 1 CEP170 SDCCAG8
Arm fat mass (right) 1.20 1 0 0 0 1 CEP170
Standing height 0.34 1 0 0 0 1 CTTNBP2
Length of working week for main job 4.30 1 0 0 0 1 CTTNBP2
Breastfed as a baby 2.31 1 0 0 0 1 CTTNBP2
Seen doctor (GP) for nerves, anxiety, tension or depression 4.85 1 0 0 0 1 CTTNBP2
Birth weight of first child 1.98 1 0 0 0 1 SDCCAG8
Peak expiratory flow (PEF) 1.93 1 0 0 0 1 CTTNBP2
Qualifications: O levels/GCSEs or equivalent 4.77 3 0 0 0 1 CEP170 CTTNBP2 SDCCAG8
Medication: Paracetamol 6.87 1 0 0 0 1 SDCCAG8
Glaucoma (self-reported) 4.54 2 0 0 0 1 CTTNBP2 SDCCAG8
Medication: Ventolin 100micrograms inhaler 2.27 1 0 0 0 1 SDCCAG8
Chronic bronchitis/emphysema (mother) 2.42 1 0 0 0 1 CEP170
Body fat percentage 1.44 1 0 0 0 1 CEP170
Leg fat percentage (right) 1.66 1 0 0 0 1 CEP170
Number of full brothers 3.24 1 0 0 0 1 SDCCAG8
Worry too long after embarrassment 3.06 1 0 0 0 1 CTTNBP2
Seen a psychiatrist for nerves, anxiety, tension or depression 3.58 1 0 0 0 1 CTTNBP2
Wheeze or whistling in the chest in last year 3.66 2 0 0 0 1 CEP170 SDCCAG8
Age at first live birth 4.42 3 0 0 0 1 CEP170 CTTNBP2 SDCCAG8
Health satisfaction 4.23 2 0 0 0 1 CEP170 SDCCAG8
Shortness of breath walking on level ground 2.15 1 0 0 0 1 CEP170
Qualifications: College or University degree 7.00 3 1 3 0 1 CEP170 CTTNBP2 SDCCAG8
Medication for pain relief, constipation, heartburn 4.27 1 0 0 0 1 SDCCAG8
Medication: Seretide 50 evohaler 3.48 1 0 0 0 1 CEP170
Mean time to correctly identify matches 2.35 2 0 0 0 1 CEP170 SDCCAG8
Whole body fat mass 1.15 1 0 0 0 1 CEP170
Leg fat mass (right) 1.42 2 0 0 0 1 CEP170 SDCCAG8
Alcohol intake frequency. 2.67 2 0 0 0 1 CEP170 SDCCAG8
Comparative height size at age 10 0.61 1 0 0 0 1 CTTNBP2
Overall health rating 7.22 2 0 0 0 1 CEP170 SDCCAG8
Age at last live birth 4.94 1 0 0 0 1 CEP170
Qualifications: NVQ or HND or HNC or equivalent 6.50 1 0 0 0 1 SDCCAG8
Illness, injury, bereavement, stress in last 2 years 6.30 1 0 0 0 1 CTTNBP2
Knee pain experienced in last month 2.82 1 0 0 0 1 SDCCAG8
Hypertension (Self-reported) 1.83 1 0 0 0 1 SDCCAG8
Arm fat percentage (left) 1.22 1 0 0 0 1 CEP170
Average weekly red wine intake 3.11 1 0 0 0 1 CTTNBP2
Mood swings 4.15 1 0 0 0 1 CTTNBP2
Loneliness, isolation 3.22 1 0 0 0 1 CEP170
Long-standing illness, disability or infirmity 3.97 1 0 0 0 1 CEP170
Ever had bowel cancer screening 3.24 1 0 0 0 1 CTTNBP2
Diabetes diagnosed by doctor 1.52 1 0 0 0 1 CTTNBP2
Qualifications: nursing, teaching 8.29 2 1 3 0 1 CTTNBP2 SDCCAG8
Mouth/teeth dental problems: Mouth ulcers 3.29 1 0 0 0 1 SDCCAG8
Medication for cholesterol 2.75 1 0 0 0 1 SDCCAG8
Back pain experienced in last month 2.16 1 0 0 0 1 SDCCAG8
Smoking status: Current 4.79 1 0 0 0 1 CTTNBP2
Arm fat mass (left) 1.09 1 0 0 0 1 CEP170
Number of self-reported non-cancer illnesses 3.67 2 0 0 0 1 CEP170 SDCCAG8
Average weekly champagne plus white wine intake 4.36 2 0 0 0 1 CEP170 SDCCAG8
Miserableness 6.56 2 0 0 0 1 CTTNBP2 SDCCAG8
Guilty feelings 4.56 2 0 0 0 1 CTTNBP2 SDCCAG8
Wears glasses or contact lenses 5.00 1 0 0 0 1 SDCCAG8
Mother's age at death 5.72 2 0 0 0 1 CEP170 SDCCAG8
Financial situation satisfaction 6.38 2 0 0 0 1 CEP170 SDCCAG8
Medication: Blood pressure 1.48 1 0 0 0 1 SDCCAG8
Medication: Paracetamol 5.09 1 0 0 0 1 SDCCAG8
Medication: Lisinopril 2.14 1 0 0 0 1 SDCCAG8
Ever smoked 7.89 1 1 3 0 1 CTTNBP2
Leg fat percentage (left) 1.78 1 0 0 0 1 CEP170
Number of operations (self-reported) 2.37 1 0 0 0 1 SDCCAG8
Average weekly beer plus cider intake 4.59 1 0 0 0 1 CTTNBP2
Fractured/broken bones in last 5 years 4.13 1 0 0 0 1 CTTNBP2
Diastolic blood pressure, automated reading 4.28 2 1 3 0 1 CEP170 SDCCAG8
Myopia 2.56 1 0 0 0 1 SDCCAG8
Vascular/heart problems diagnosed by doctor 2.06 1 0 0 0 1 SDCCAG8
Cholesterol lowering medication 3.34 1 0 0 0 1 SDCCAG8
Pain experienced in last month 1.81 1 0 0 0 1 SDCCAG8
Alcohol drinker status: Previous 4.93 1 0 0 0 1 CTTNBP2
Leg fat mass (left) 1.48 2 0 0 0 1 CEP170 SDCCAG8

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.34
GTEx Adipose Visceral Omentum 1 0.0491 1.40
GTEx Adrenal Gland 0 0.0000 1.30
GTEx Artery Aorta 0 0.0000 1.32
GTEx Artery Coronary 0 0.0000 1.38
GTEx Artery Tibial 0 0.0000 1.31
GTEx Brain Caudate basal ganglia 0 0.0000 1.35
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.39
GTEx Brain Cerebellum 0 0.0000 1.40
GTEx Brain Cortex 0 0.0000 1.45
GTEx Brain Frontal Cortex BA9 0 0.0000 1.54
GTEx Brain Hippocampus 0 0.0000 1.42
GTEx Brain Hypothalamus 0 0.0000 1.40
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.36
GTEx Brain Putamen basal ganglia 0 0.0000 1.32
GTEx Breast Mammary Tissue 0 0.0000 1.35
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.30
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.34
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.35
GTEx Cells Transformed fibroblasts 1 0.0238 1.38
GTEx Colon Sigmoid 0 0.0000 1.34
GTEx Colon Transverse 0 0.0000 1.31
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.34
GTEx Esophagus Mucosa 0 0.0000 1.39
GTEx Esophagus Muscularis 0 0.0000 1.34
GTEx Heart Atrial Appendage 0 0.0000 1.35
GTEx Heart Left Ventricle 0 0.0000 1.34
GTEx Liver 0 0.0000 1.28
GTEx Lung 0 0.0000 1.29
GTEx Muscle Skeletal 0 0.0000 1.39
GTEx Nerve Tibial 0 0.0000 1.32
GTEx Ovary 0 0.0000 1.36
GTEx Pancreas 0 0.0000 1.40
GTEx Pituitary 0 0.0000 1.35
GTEx Prostate 0 0.0000 1.34
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.34
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.31
GTEx Small Intestine Terminal Ileum 0 0.0000 1.50
GTEx Spleen 0 0.0000 1.41
GTEx Stomach 0 0.0000 1.34
GTEx Testis 0 0.0000 1.36
GTEx Thyroid 1 0.0250 1.35
GTEx Uterus 0 0.0000 1.31
GTEx Vagina 0 0.0000 1.45
GTEx Whole Blood 0 0.0000 1.43
METSIM Adipose 0 0.0000 1.30
NTR Blood 0 0.0000 1.40
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.36
YFS Blood 0 0.0000 1.28
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.36
TCGA Breast Tumor 0 0.0000 1.41
TCGA Breast Normal 0 0.0000 1.30
TCGA Ovarian Tumor 0 0.0000 1.35
TCGA Prostate Tumor 0 0.0000 1.30