Hub : Traits :

Relative age voice broke

345 significantly associated models · 32 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 4 94527983 95955095 1 1 2.0e-08 4.1e-08 1.0e+00 100 HPGDS
2 6 99324687 100719911 1 1 3.5e-08 1.6e-08 5.6e-04 63 RP1-199J3.5
3 6 104478130 106230491 2 1 1.6e-21 1.7e-32 7.2e-13 64 LIN28B
4 9 107767036 109216841 1 1 1.1e-08 6.2e-19 1.7e-12 37 TMEM38B
5 10 116155718 118404700 1 1 1.1e-07 2.6e-04 3.5e-01 94 ATRNL1
6 11 122058476 123525464 1 2 2.7e-10 1.2e-10 1.0e+00 100 C11orf63
7 15 88358250 89773505 1 1 2.0e-07 7.1e-08 1.0e+00 100 DET1
8 16 3608256 5001380 1 1 3.9e-07 2.1e-06 3.2e-01 96 RP11-95P2.1
9 16 13697975 14759768 1 1 5.4e-08 8.8e-18 1.9e-11 39 RP11-65J21.3
10 16 89189472 90172696 1 1 4.6e-08 1.9e-06 4.4e-03 64 SPIRE2
11 17 42607368 45796313 20 1 7.4e-15 1.1e-13 1.0e+00 100 LRRC37A4P
12 20 33197489 34697305 1 1 2.2e-07 1.6e-06 8.2e-01 100 UQCC1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Verbal and Numeric Reasoning (VNR) 0.89 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Breast Cancer 2.14 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Ovarian Cancer 3.51 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Prostate Cancer 1.55 1 0 0.0 0.00 1.0e+00 UQCC1
Age at First Birth 1.87 1 0 0.0 0.00 1.0e+00 SPIRE2
Neuroticism 2.51 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Primary Biliary Cirrhosis 2.02 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Schizophrenia 2.14 1 0 0.0 0.00 1.0e+00 LIN28B
Blood Eosinophil Count 1.60 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Blood Platelet Count 0.99 3 2 6.1 0.00 1.0e+00 HPGDS LRRC37A4P RP11-95P2.1
Blood Red Count 3.92 2 1 3.0 0.00 1.0e+00 LRRC37A4P SPIRE2
Blood White Count 0.93 2 1 3.0 0.00 1.0e+00 LRRC37A4P SPIRE2
Heel T-Score 3.30 6 3 9.1 0.76 4.6e-02 C11orf63 DET1 LIN28B LRRC37A4P RP11-95P2.1 SPIRE2
BMI 0.62 1 0 0.0 0.00 1.0e+00 RP11-95P2.1
Height 9.83 8 8 24.2 -0.19 6.3e-01 C11orf63 DET1 LIN28B LRRC37A4P RP11-65J21.3 RP11-95P2.1 TMEM38B UQCC1
Waist Hip Ratio (WHR) 3.78 3 3 9.1 0.00 1.0e+00 LRRC37A4P RP11-95P2.1 UQCC1
Systolic Blood Pressure 2.23 2 2 6.1 0.00 1.0e+00 LRRC37A4P UQCC1
Lung FEV1/FVC ratio 1.61 2 1 3.0 0.00 1.0e+00 LRRC37A4P RP11-95P2.1
Lung FVC 7.27 3 3 9.1 0.00 1.0e+00 LIN28B LRRC37A4P UQCC1
Neuroticism 5.02 3 1 3.0 0.00 1.0e+00 LIN28B LRRC37A4P SPIRE2
Hair Pigment 89.72 3 2 6.1 0.00 1.0e+00 LRRC37A4P SPIRE2 UQCC1
Tanning 61.41 2 2 6.1 0.00 1.0e+00 SPIRE2 UQCC1
Hand grip strength (left) 5.76 3 2 6.1 0.00 1.0e+00 LIN28B LRRC37A4P UQCC1
Number of treatments/medications taken 1.97 1 0 0.0 0.00 1.0e+00 LIN28B
Sensitivity / hurt feelings 5.41 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Relative age of first facial hair 22.41 9 8 24.2 0.99 3.8e-08 C11orf63 DET1 HPGDS LIN28B LRRC37A4P RP11-65J21.3 RP1-199J3.5 SPIRE2 UQCC1
Systolic blood pressure, automated reading 2.51 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Vitamin and mineral supplements 1.40 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Impedance of leg (right) 2.28 3 1 3.0 0.00 1.0e+00 LIN28B LRRC37A4P UQCC1
Leg fat-free mass (left) 5.60 3 1 3.0 0.00 1.0e+00 LIN28B RP11-95P2.1 UQCC1
Trunk fat percentage 2.74 4 2 6.1 -0.65 3.5e-01 C11orf63 LRRC37A4P RP11-95P2.1 SPIRE2
Hand grip strength (right) 6.06 3 2 6.1 0.00 1.0e+00 LIN28B LRRC37A4P UQCC1
Fed-up feelings 2.01 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Age when periods started (menarche) 27.03 8 6 18.2 0.95 9.9e-05 ATRNL1 C11orf63 DET1 HPGDS LIN28B LRRC37A4P RP11-65J21.3 TMEM38B
Heel bone mineral density (BMD) T-score, automated (left) 1.97 2 0 0.0 0.00 1.0e+00 LIN28B LRRC37A4P
Sitting height 10.97 4 3 9.1 -0.87 1.3e-01 LRRC37A4P RP11-65J21.3 RP11-95P2.1 UQCC1
Impedance of leg (left) 2.51 3 1 3.0 0.00 1.0e+00 LIN28B LRRC37A4P UQCC1
Leg predicted mass (left) 5.58 3 1 3.0 0.00 1.0e+00 LIN28B RP11-95P2.1 UQCC1
Trunk fat mass 3.27 6 3 9.1 -0.21 6.9e-01 C11orf63 LIN28B LRRC37A4P RP11-95P2.1 SPIRE2 UQCC1
Nervous feelings 2.78 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Frequency of tenseness / restlessness in last 2 weeks 2.66 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Hearing difficulty/problems with background noise 2.54 2 0 0.0 0.00 1.0e+00 LIN28B LRRC37A4P
Hair/balding pattern: Pattern 2 3.30 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Forced vital capacity (FVC) 4.66 3 2 6.1 0.00 1.0e+00 LRRC37A4P RP11-65J21.3 UQCC1
Heel bone mineral density (BMD) T-score, automated (right) 2.22 2 0 0.0 0.00 1.0e+00 LIN28B LRRC37A4P
Ever unenthusiastic/disinterested for a whole week 2.10 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Neuroticism score 4.02 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Weight 3.74 4 2 6.1 0.23 7.7e-01 C11orf63 LIN28B RP11-95P2.1 UQCC1
Impedance of arm (right) 3.22 2 2 6.1 0.00 1.0e+00 LIN28B LRRC37A4P
Trunk fat-free mass 6.51 3 2 6.1 0.00 1.0e+00 LIN28B RP11-65J21.3 UQCC1
Hip circumference 3.05 2 2 6.1 0.00 1.0e+00 RP11-95P2.1 UQCC1
Worrier / anxious feelings 1.94 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Hair/balding pattern: Pattern 3 5.50 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Number of live births 1.97 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Forced expiratory volume in 1-second (FEV1) 4.47 2 2 6.1 0.00 1.0e+00 LRRC37A4P RP11-65J21.3
Qualifications: A levels/AS levels or equivalent 1.55 2 0 0.0 0.00 1.0e+00 LRRC37A4P UQCC1
Forced expiratory volume in 1-second (FEV1), Best measure 3.86 2 1 3.0 0.00 1.0e+00 LRRC37A4P RP11-65J21.3
Impedance of arm (left) 3.78 5 2 6.1 0.34 5.7e-01 DET1 LIN28B LRRC37A4P SPIRE2 UQCC1
Arm fat mass (right) 1.30 2 0 0.0 0.00 1.0e+00 RP11-95P2.1 UQCC1
Trunk predicted mass 6.56 3 2 6.1 0.00 1.0e+00 LIN28B RP11-65J21.3 UQCC1
Standing height 9.68 8 8 24.2 0.18 6.5e-01 C11orf63 DET1 LIN28B LRRC37A4P RP11-65J21.3 RP11-95P2.1 TMEM38B UQCC1
Hair/balding pattern: Pattern 4 8.41 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Peak expiratory flow (PEF) 5.34 3 3 9.1 0.00 1.0e+00 LRRC37A4P RP11-65J21.3 UQCC1
Medication: Paracetamol 3.09 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Headache pain in last month 2.97 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Forced vital capacity (FVC), Best measure 4.41 3 2 6.1 0.00 1.0e+00 LRRC37A4P RP11-65J21.3 UQCC1
Body fat percentage 1.97 4 0 0.0 -0.66 3.4e-01 C11orf63 LRRC37A4P RP11-95P2.1 SPIRE2
Leg fat percentage (right) 1.69 2 0 0.0 0.00 1.0e+00 RP11-95P2.1 UQCC1
Arm fat-free mass (right) 5.14 2 2 6.1 0.00 1.0e+00 RP11-65J21.3 UQCC1
Comparative body size at age 10 2.09 2 1 3.0 0.00 1.0e+00 C11orf63 LIN28B
Worry too long after embarrassment 1.92 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Qualifications: College or University degree 2.19 3 1 3.0 0.00 1.0e+00 HPGDS LRRC37A4P UQCC1
Medication for pain relief, constipation, heartburn 2.20 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Neck or shoulder pain in last month 1.63 1 0 0.0 0.00 1.0e+00 SPIRE2
Whole body fat mass 2.27 3 1 3.0 0.00 1.0e+00 C11orf63 RP11-95P2.1 UQCC1
Leg fat mass (right) 1.45 1 1 3.0 0.00 1.0e+00 RP11-95P2.1
Arm predicted mass (right) 5.20 3 2 6.1 0.00 1.0e+00 RP11-65J21.3 RP11-95P2.1 UQCC1
Pulse rate, automated reading 1.54 2 1 3.0 0.00 1.0e+00 RP11-95P2.1 RP1-199J3.5
Alcohol intake frequency. 1.60 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Comparative height size at age 10 6.65 3 2 6.1 0.00 1.0e+00 LRRC37A4P RP1-199J3.5 UQCC1
Suffer from 'nerves' 1.53 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Knee pain experienced in last month 3.32 1 1 3.0 0.00 1.0e+00 UQCC1
Forced expiratory volume in 1-second (FEV1), predicted 6.67 3 2 6.1 0.00 1.0e+00 C11orf63 LIN28B UQCC1
Whole body fat-free mass 6.18 3 2 6.1 0.00 1.0e+00 LIN28B RP11-65J21.3 UQCC1
Leg fat-free mass (right) 5.69 2 1 3.0 0.00 1.0e+00 LIN28B UQCC1
Handedness (chirality/laterality): Left-handed 3.41 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Mood swings 3.37 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Loneliness, isolation 1.58 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Ever had stillbirth, spontaneous miscarriage or termination 2.83 1 0 0.0 0.00 1.0e+00 RP11-95P2.1
Friendships satisfaction 2.18 1 0 0.0 0.00 1.0e+00 RP11-65J21.3
Mouth/teeth dental problems: Mouth ulcers 3.05 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.03 2 1 3.0 0.00 1.0e+00 LRRC37A4P UQCC1
Whole body water mass 6.01 3 2 6.1 0.00 1.0e+00 LIN28B RP11-65J21.3 UQCC1
Leg predicted mass (right) 5.67 2 1 3.0 0.00 1.0e+00 LIN28B UQCC1
Arm fat mass (left) 1.35 2 0 0.0 0.00 1.0e+00 RP11-95P2.1 UQCC1
Average weekly champagne plus white wine intake 1.95 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Miserableness 2.39 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Guilty feelings 3.56 2 1 3.0 0.00 1.0e+00 LIN28B LRRC37A4P
Medication: Blood pressure 2.05 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Medication: Paracetamol 2.74 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Basal metabolic rate 5.61 4 1 3.0 0.17 8.3e-01 LIN28B RP11-65J21.3 RP11-95P2.1 UQCC1
Leg fat percentage (left) 1.78 2 0 0.0 0.00 1.0e+00 RP11-95P2.1 UQCC1
Arm fat-free mass (left) 5.09 3 1 3.0 0.00 1.0e+00 RP11-65J21.3 RP11-95P2.1 UQCC1
Number of operations (self-reported) 1.83 1 0 0.0 0.00 1.0e+00 LIN28B
Irritability 2.58 1 1 3.0 0.00 1.0e+00 LRRC37A4P
Myopia 1.26 1 0 0.0 0.00 1.0e+00 LRRC37A4P
Basal cell carcinoma (self-reported) 2.78 1 1 3.0 0.00 1.0e+00 SPIRE2
Impedance of whole body 3.18 4 3 9.1 0.35 6.5e-01 LIN28B LRRC37A4P SPIRE2 UQCC1
Leg fat mass (left) 1.52 1 1 3.0 0.00 1.0e+00 RP11-95P2.1
Arm predicted mass (left) 5.21 2 2 6.1 0.00 1.0e+00 RP11-65J21.3 UQCC1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 7 0.2005 1.59
GTEx Adipose Visceral Omentum 6 0.2947 1.65
GTEx Adrenal Gland 5 0.3432 1.61
GTEx Artery Aorta 8 0.2687 1.58
GTEx Artery Coronary 9 0.7608 1.94
GTEx Artery Tibial 5 0.1329 1.51
GTEx Brain Caudate basal ganglia 5 0.5435 1.73
GTEx Brain Cerebellar Hemisphere 7 0.4701 1.72
GTEx Brain Cerebellum 6 0.3027 1.68
GTEx Brain Cortex 7 0.6763 1.84
GTEx Brain Frontal Cortex BA9 5 0.5411 1.86
GTEx Brain Hippocampus 5 0.9542 1.98
GTEx Brain Hypothalamus 5 0.8475 1.86
GTEx Brain Nucleus accumbens basal ganglia 7 0.8092 1.84
GTEx Brain Putamen basal ganglia 5 0.8013 1.78
GTEx Breast Mammary Tissue 7 0.3546 1.63
GTEx Breast Mammary Tissue (Male) 8 0.6706 1.66
GTEx Breast Mammary Tissue (Female) 7 0.4258 1.76
GTEx Cells EBV-transformed lymphocytes 9 0.6325 1.86
GTEx Cells Transformed fibroblasts 10 0.2382 1.52
GTEx Colon Sigmoid 7 0.4788 1.74
GTEx Colon Transverse 8 0.3876 1.75
GTEx Esophagus Gastroesophageal Junction 7 0.4844 1.72
GTEx Esophagus Mucosa 10 0.3012 1.58
GTEx Esophagus Muscularis 10 0.3094 1.59
GTEx Heart Atrial Appendage 7 0.4433 1.71
GTEx Heart Left Ventricle 7 0.4575 1.71
GTEx Liver 4 0.5579 1.61
GTEx Lung 10 0.3481 1.64
GTEx Muscle Skeletal 9 0.3114 1.54
GTEx Nerve Tibial 8 0.1851 1.56
GTEx Ovary 6 0.6608 1.88
GTEx Pancreas 9 0.5515 1.67
GTEx Pituitary 5 0.4484 1.66
GTEx Prostate 5 0.5988 1.66
GTEx Skin Not Sun Exposed Suprapubic 8 0.3253 1.65
GTEx Skin Sun Exposed Lower leg 9 0.2473 1.55
GTEx Small Intestine Terminal Ileum 4 0.8677 1.89
GTEx Spleen 5 0.3544 1.61
GTEx Stomach 7 0.4814 1.74
GTEx Testis 11 0.3487 1.62
GTEx Thyroid 13 0.3251 1.63
GTEx Uterus 6 1.0582 1.95
GTEx Vagina 5 0.7874 1.71
GTEx Whole Blood 5 0.2509 1.46
METSIM Adipose 1 0.0217 1.36
NTR Blood 3 0.1249 1.35
ROSMAP Brain Pre-frontal Cortex 3 0.0683 1.46
YFS Blood 1 0.0217 1.35
CommonMind Brain Pre-frontal Cortex 4 0.0744 1.42
TCGA Breast Tumor 2 0.2608 1.45
TCGA Breast Normal 3 0.0713 1.37
TCGA Ovarian Tumor 5 0.1711 1.42
TCGA Prostate Tumor 5 0.1446 1.42