Hub : Genes

ANXA2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 YFS Blood 0.1725 0.0266 0.00000 0.137 0.124 0.150 0.143 0.147 1.2e-42 2.3e-38 1.0e-46 2.7e-44 1.4e-45
2 TCGA Lung Squamous Cell Carcinoma 0.0379 0.0168 0.00067 0.041 0.035 0.043 NA 0.044 1.8e-05 6.2e-05 1.1e-05 NA 9.0e-06
3 TCGA Prostate Adenocarcinoma 0.1389 0.0573 0.00170 0.039 0.044 0.045 NA 0.049 6.2e-05 2.2e-05 1.7e-05 NA 7.5e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.0 0.0 0.0 -0.1 -0.1 -0.1
Bipolar Disorder or Schizophrenia 0.5 1.3 3.1 -0.6 0.7 -1.8
Depressed Affect (Nagel 2018) 0.3 0.6 1.5 0.5 0.3 1.2
Depression (Nagel 2018) 0.2 0.3 0.9 0.9 -0.2 0.1
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.6 0.5 0.1 0.8
Neuroticism (Nagel 2018) 1.8 4.3 7.6 2.8 0.4 2.3
Schizophrenia (2018) 1.0 2.1 4.7 -0.6 1.0 -2.2
Schizophrenia vs Biploar Disorder 0.4 0.5 1.1 -0.3 1.0 -0.7
Worry (Nagel 2018) 3.5 7.4 13.2 3.6 0.4 3.0
Alzheimer’s Disease (in mother) 0.3 0.4 0.7 -0.4 -0.5 -0.8
Alzheimer’s Disease (in father) 0.4 0.4 0.6 0.7 -0.7 -0.5
Alzheimer’s Disease (including proxy) 0.3 0.4 0.6 -0.3 -0.7 -0.7
Crohns Disease (2017) 0.2 0.4 1.1 0.4 0.0 -1.0
Irritable Bowel Disease (IBD) 0.3 0.8 1.8 0.1 0.8 -1.3
Ulcerative Colitis (UC) 0.3 0.6 1.1 -0.4 0.7 -1.1
Major Depression (MDD) 1.3 1.6 4.1 0.6 2.0 0.6
Reaction Time 0.2 0.3 0.6 -0.6 0.7 0.4
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.4 0.2 0.6 0.4
Breast Cancer 0.8 1.8 5.4 -0.3 -2.3 0.0
Ovarian Cancer 0.6 0.8 1.5 -0.0 -0.9 -1.2
Prostate Cancer 0.4 0.5 1.2 -1.1 0.3 0.5
Age at First Birth 2.0 2.9 6.3 -1.0 -2.5 -1.2
Bipolar Disorder (2011) 0.3 0.2 0.6 -0.2 0.8 -0.1
Body Mass Index (BMI) (2010) 0.1 0.2 0.3 0.1 -0.4 -0.6
Coronary Artery Disease (CAD) 0.6 0.7 1.3 -1.1 0.8 -0.3
Crohns Disease (2012) 0.9 1.5 3.4 -0.8 -0.8 -1.8
Mean Putamen Volume 4.4 5.0 9.9 -2.1 -0.8 -3.1
Fasting Glucose 0.7 0.8 2.3 -0.3 0.1 1.5
HbA1C 0.7 0.8 1.9 1.4 0.4 -0.4
HDL Cholesterol 0.1 0.1 0.2 0.1 0.3 -0.5
LDL Cholesterol 0.4 0.6 1.1 0.0 -1.1 0.9
Lupus 0.1 0.1 0.2 0.3 0.4 0.1
Neuroticism (2016) 3.4 4.9 8.2 2.9 -0.6 2.5
Primary Biliary Cirrhosis 1.8 2.6 3.3 1.8 -1.6 1.3
Rheumatoid Arthritis 1.0 1.4 1.9 1.3 1.4 0.7
Schizophrenia (2014) 1.7 3.6 6.6 -1.7 1.2 -2.6
Triglycerides 0.2 0.4 0.7 -0.1 -0.8 -0.6
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.8 0.9 -0.3 1.3
Ulcerative Colitis 1.0 1.4 1.9 -1.1 1.4 -1.1
Blood Eosinophil Count 0.9 7.0 18.5 -4.3 -0.1 -1.6
Blood Platelet Count 0.2 2.9 3.9 -1.4 1.6 -2.0
Blood Red Count 0.2 1.5 3.0 1.2 0.1 1.7
Blood White Count 0.8 5.7 8.8 3.0 -2.3 1.8
Heel T-Score 0.1 0.7 1.3 1.1 -0.8 -0.4
BMI 0.4 2.4 5.3 2.3 -0.2 -1.3
Height 0.7 13.9 27.5 -3.1 -2.2 -5.2
Waist Hip Ratio (WHR) 1.7 7.7 13.0 2.9 -1.3 3.6
Systolic Blood Pressure 0.8 4.1 6.8 2.6 -2.3 -0.4
Smoking Status 0.3 0.8 1.7 -0.4 1.3 -0.7
Allergy or Eczema 0.4 1.0 2.7 -0.4 -1.6 -0.4
Cardiovascular Disease 0.9 2.9 6.7 2.6 -0.7 -1.2
Hypothyroidism (self reported) 0.7 1.6 4.5 2.1 0.5 -0.3
Respiratory disease 2.6 5.8 6.4 -2.5 -2.5 -2.2
Type 2 Diabetes (T2D) (2018) 0.6 1.2 2.8 1.7 -0.9 -0.2
Lung FEV1/FVC ratio 1.0 5.2 11.0 -0.3 3.3 2.1
Lung FVC 0.4 2.0 3.6 -1.5 -0.3 1.9
Neuroticism 2.3 5.5 10.9 2.4 0.2 3.3
Chronotype (morning person) 0.5 1.3 2.6 -1.0 1.6 -0.3
Hair Pigment 0.2 4.4 10.9 1.3 -3.3 -0.7
Tanning 0.0 0.2 0.4 -0.5 0.3 -0.6
Hand grip strength (left) 0.9 2.4 3.3 -1.1 -1.6 -1.8
Number of treatments/medications taken 1.1 2.0 5.8 2.4 -0.5 -0.0
Average weekly spirits intake 0.1 0.1 0.2 0.1 -0.2 -0.5
Sensitivity / hurt feelings 1.1 1.9 3.1 1.6 -0.0 1.8
Frequency of depressed mood in last 2 weeks 0.7 1.0 1.7 1.2 -1.3 0.1
Hearing difficulty/problems: Yes 2.1 3.2 7.1 1.3 -0.9 2.7
Relative age of first facial hair 10.7 22.1 34.5 -5.9 -1.4 -5.5
Other serious medical condition/disability diagnosed by doctor 2.2 2.8 4.6 2.1 0.2 1.9
Ever used hormone-replacement therapy (HRT) 1.9 2.4 6.1 2.5 0.3 1.1
Ever had hysterectomy (womb removed) 2.7 3.0 3.5 1.9 1.9 1.4
Systolic blood pressure, automated reading 0.7 2.0 4.3 2.1 -1.3 0.3
Eye problems/disorders: Diabetes related eye disease 0.4 0.5 1.3 -0.1 -1.1 -0.3
Angina 1.2 1.6 2.2 -1.3 -1.0 -1.5
Medication for hormone replacement therapy 1.3 1.4 3.6 0.2 0.8 1.9
Vitamin and mineral supplements 3.6 4.9 10.9 -3.3 0.7 -1.8
Supplements: Zinc 0.6 0.7 0.9 1.0 0.3 1.0
Medication: Co-codamol 0.7 0.8 1.5 1.0 0.0 -1.2
Medication: Metformin 0.1 0.2 0.3 0.6 -0.0 -0.5
Diabetes (father) 1.1 1.3 3.2 0.4 -1.8 0.8
Diabetes (mother) 0.7 0.9 1.7 1.3 -1.0 -0.0
Severe depression (siblings) 0.9 1.0 1.5 1.2 0.8 0.9
Pack years adult smoking proportion 1.1 1.6 2.4 1.5 0.4 1.6
Impedance of leg (right) 0.6 2.7 6.8 -0.5 2.6 -1.0
Leg fat-free mass (left) 0.8 4.1 7.5 0.1 -2.7 -2.2
Trunk fat percentage 0.7 2.6 4.0 2.0 -0.6 -1.9
Hand grip strength (right) 1.3 3.4 4.6 -1.6 -1.7 -2.1
Townsend deprivation index at recruitment 0.2 0.2 0.6 0.8 -0.0 0.1
Current tobacco smoking 0.6 1.0 2.8 -0.2 1.7 0.4
Average weekly fortified wine intake 1.8 2.1 4.6 -2.1 0.2 -1.3
Maternal smoking around birth 0.8 1.1 1.5 -1.2 1.1 -0.8
Fed-up feelings 0.4 0.8 0.9 1.0 -0.9 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 2.3 1.1 -0.0 1.5
Relative age voice broke 11.3 17.2 28.6 -4.8 -0.3 -5.3
Taking other prescription medications 2.2 3.3 7.7 2.8 -1.5 -0.4
Age when periods started (menarche) 12.1 29.0 42.3 -6.3 -2.2 -6.5
Bilateral oophorectomy (both ovaries removed) 3.4 3.9 7.6 1.9 0.5 2.8
Heel bone mineral density (BMD) T-score, automated (left) 1.3 3.0 4.9 2.2 0.1 2.0
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.1 0.1 0.3 0.4
Qualifications: CSEs or equivalent 0.3 0.4 0.5 -0.6 -0.6 -0.7
Serious illness, injury or assault to yourself 0.7 0.8 1.7 1.3 0.7 -0.5
High blood pressure 1.8 5.0 13.5 3.7 -1.1 0.6
Hayfever, allergic rhinitis or eczema 0.5 1.2 3.1 -0.7 -1.8 -0.1
Multivitamins +/- minerals 3.4 4.3 7.6 2.8 -1.5 1.7
Stomach or abdominal pain in last month 0.2 0.2 0.3 -0.5 0.5 -0.4
Supplements: Glucosamine 0.1 0.1 0.2 -0.4 -0.0 0.2
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.4 0.1 -1.2 0.2
Medication: Atenolol 0.5 0.7 1.3 1.2 0.8 0.2
Medication: Levothyroxine sodium 0.8 1.3 2.2 1.5 0.4 -1.3
Sitting height 0.5 3.7 7.7 -2.8 -1.2 -1.4
Chronic bronchitis/emphysema (father) 0.0 0.1 0.1 0.4 0.1 -0.2
High blood pressure (mother) 0.3 0.5 0.9 1.0 0.7 -0.1
Body mass index (BMI) 0.4 1.6 1.9 1.4 -1.0 -1.3
Impedance of leg (left) 0.5 2.5 7.0 -0.3 2.6 -0.7
Leg predicted mass (left) 0.8 4.0 7.4 0.2 -2.7 -2.2
Trunk fat mass 0.7 3.1 5.7 1.4 -1.2 -2.4
Waist circumference 0.8 3.0 4.5 2.1 -2.1 -0.5
Number of incorrect matches in round 0.5 0.9 1.7 0.7 -0.6 1.3
Past tobacco smoking 0.4 0.8 2.1 -1.4 -0.2 0.4
Alcohol usually taken with meals 0.2 0.3 0.8 -0.0 -0.9 -0.4
Nervous feelings 4.8 9.0 13.9 3.7 1.4 3.3
Frequency of tenseness / restlessness in last 2 weeks 2.4 3.8 8.5 1.3 1.0 2.9
Hearing difficulty/problems with background noise 2.5 3.9 8.1 1.3 1.4 2.8
Hair/balding pattern: Pattern 2 1.2 1.6 4.2 2.1 -0.2 0.6
Had menopause 1.6 2.1 4.5 2.1 0.9 1.0
Had other major operations 0.1 0.1 0.2 -0.2 0.5 -0.2
Forced vital capacity (FVC) 0.5 1.9 3.5 -1.9 -1.5 -0.0
Heel bone mineral density (BMD) T-score, automated (right) 1.7 3.8 7.3 2.7 -0.5 2.0
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 0.8 0.9 -0.1 0.7
Qualifications: None of the above 0.0 0.1 0.2 -0.4 0.1 0.2
Financial difficulties in last 2 years 0.3 0.4 0.5 -0.5 -0.6 -0.7
Mouth/teeth dental problems 1.9 2.8 4.7 -0.2 -2.2 -1.9
Heart attack 1.4 1.8 3.8 -0.9 -2.0 -0.8
Allergy 1.0 2.4 5.8 0.5 2.4 1.0
Pain all over the body in last month 5.0 5.3 7.2 1.9 2.3 2.7
Diabetes (self-reported) 1.3 2.0 5.2 2.3 -0.6 0.7
Hayfever/allergic rhinitis (self-reported) 1.9 2.5 6.5 -0.7 -2.5 -0.7
Medication: Ramipril 0.4 0.5 1.4 -0.4 -1.2 -0.0
Medication: Simvastatin 0.4 0.5 0.9 1.0 -0.1 -0.8
Fluid intelligence score 0.2 0.4 0.8 -0.6 0.9 0.4
Illnesses of siblings 0.3 0.4 1.0 -0.2 -0.3 1.0
Neuroticism score 2.3 4.9 8.3 2.5 -0.3 2.9
Weight 0.7 3.4 7.5 0.4 -1.6 -2.7
Impedance of arm (right) 0.1 0.6 1.7 0.4 1.3 -0.0
Arm fat percentage (right) 0.5 2.0 3.8 2.0 -0.4 -1.4
Trunk fat-free mass 0.7 3.8 6.2 -1.0 -2.1 -2.5
Hip circumference 1.1 4.7 9.8 0.3 -2.0 -3.1
Time employed in main current job 3.2 3.7 9.2 3.0 -0.1 1.4
Alcohol intake versus 10 years previously 0.1 0.1 0.3 -0.5 -0.1 -0.0
Father’s age at death 5.9 7.9 18.6 -2.1 -0.8 -4.3
Worrier / anxious feelings 0.8 1.5 3.0 1.1 -0.6 1.7
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.4 3.3 0.7 -0.5 1.8
Falls in the last year 0.3 0.4 0.9 -0.9 -0.3 0.3
Hair/balding pattern: Pattern 3 0.1 0.1 0.1 0.3 -0.2 -0.3
Number of live births 0.3 0.4 1.0 0.1 -0.2 -1.0
Forced expiratory volume in 1-second (FEV1) 0.5 1.7 4.5 -2.1 -0.6 0.5
Pulse rate 0.1 0.2 0.5 0.0 0.7 0.1
Happiness 0.2 0.2 0.7 -0.8 -0.2 0.1
Noisy workplace 0.5 0.6 1.3 0.6 1.2 0.2
Qualifications: A levels/AS levels or equivalent 0.1 0.1 0.2 0.4 0.5 0.2
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.0 0.1 0.2 0.1 -0.2
Mouth/teeth dental problems: Dentures 2.0 3.4 5.3 1.8 1.2 2.3
Asthma 3.5 7.0 12.5 -2.2 -3.5 -1.9
Medication: Ibuprofen (e.g. Nurofen) 2.4 3.1 5.6 1.3 -2.4 1.4
Medication: Cholesterol lowering 0.9 1.4 2.7 1.6 -1.2 0.3
Depression (self-reported) 4.8 5.8 8.9 3.0 1.5 2.5
Medication: Lansoprazole 0.6 0.7 2.0 1.4 -0.2 -0.0
Prospective memory result 2.3 2.8 4.4 -2.1 -1.6 -1.2
Lung cancer (father) 0.1 0.2 0.4 0.2 0.1 -0.6
Illnesses of mother 0.8 1.0 2.9 -0.1 0.2 1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 2.0 -1.4 -0.2 0.4
Pulse wave Arterial Stiffness index 0.3 0.4 0.5 0.5 -0.7 0.7
Impedance of arm (left) 0.1 0.4 0.7 0.5 0.8 0.6
Arm fat mass (right) 0.6 2.5 4.5 1.3 -1.1 -2.1
Trunk predicted mass 0.7 3.8 6.1 -1.0 -2.1 -2.5
Standing height 0.7 6.7 12.2 -2.3 -1.6 -3.5
Length of working week for main job 2.3 2.6 7.4 0.6 -2.7 -0.0
Exposure to tobacco smoke at home 0.1 0.2 0.4 -0.2 0.6 -0.2
Breastfed as a baby 1.0 1.2 2.4 -1.0 1.5 0.5
Tense / ‘highly strung’ 3.3 5.5 9.0 3.0 0.4 2.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.6 3.9 2.0 -0.1 1.0
Hair/balding pattern: Pattern 4 0.8 2.0 4.6 -1.1 -0.2 2.1
Birth weight of first child 0.6 1.1 2.3 -0.9 -0.2 -1.5
Peak expiratory flow (PEF) 1.2 2.9 5.1 0.0 -1.9 2.3
Pulse wave reflection index 0.5 0.6 1.2 0.8 -1.1 0.1
Ever highly irritable/argumentative for 2 days 1.2 1.5 3.0 1.7 0.2 1.2
Loud music exposure frequency 0.1 0.1 0.1 -0.3 0.2 0.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 0.8 0.9 -0.3 0.5
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.2 0.5 0.9 1.5
Blood clot in the leg (DVT) 2.2 2.9 4.4 2.1 -1.6 1.2
Medication: Paracetamol 0.1 0.2 0.5 0.7 -0.4 -0.2
Headache pain in last month 0.3 0.5 0.9 1.0 -0.8 0.3
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 1.7 -1.3 1.1 -0.0
Glaucoma (self-reported) 0.7 0.8 1.5 0.4 -1.2 -0.8
Gout (self-reported) 0.4 0.6 1.1 -0.5 -1.1 0.5
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 2.7 1.6 0.2 -0.6
Medication: Amlodipine 0.1 0.1 0.1 -0.3 -0.4 -0.2
Medication: Ventolin 100micrograms inhaler 3.4 4.3 6.7 -2.1 -2.6 -1.4
Birth weight 1.9 4.2 9.4 -1.7 -0.2 -3.1
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.1 -1.0 -0.2 -0.7
High blood pressure (siblings) 0.8 1.1 2.6 -0.6 -0.6 -1.6
Forced vital capacity (FVC), Best measure 0.2 0.8 1.3 -1.2 -1.0 -0.3
Body fat percentage 0.6 2.5 4.5 2.1 -0.4 -1.7
Leg fat percentage (right) 0.7 2.4 4.3 2.1 0.4 -1.7
Arm fat-free mass (right) 0.6 2.9 4.7 -0.3 -2.2 -2.0
Exposure to tobacco smoke outside home 1.1 1.4 3.6 -1.9 0.7 0.2
Comparative body size at age 10 1.6 4.4 10.1 3.2 -1.1 1.4
Number of full brothers 0.0 0.0 0.0 -0.2 0.1 -0.1
Worry too long after embarrassment 0.8 1.4 3.3 0.9 0.0 1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 2.5 3.2 5.8 2.4 1.4 1.3
Wheeze or whistling in the chest in last year 1.3 2.3 6.1 -0.3 -2.5 -0.8
Number of children fathered 0.4 0.5 0.8 -0.4 -0.9 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.8 0.2 1.4 0.7
Age at first live birth 0.7 1.2 2.1 -1.4 -0.9 0.8
Pulse wave peak to peak time 0.4 0.4 0.6 -0.6 0.5 -0.8
Health satisfaction 0.4 0.5 1.2 -0.1 1.1 -0.5
Shortness of breath walking on level ground 0.4 0.5 1.2 0.2 1.1 0.5
Qualifications: College or University degree 0.0 0.1 0.2 -0.4 0.3 0.3
Eye problems/disorders: None of the above 0.0 0.0 0.0 0.0 0.1 0.1
Mouth/teeth dental problems: Loose teeth 2.1 2.6 4.9 1.4 2.2 0.9
Emphysema/chronic bronchitis 0.9 1.0 1.9 -0.6 1.4 0.9
Medication for pain relief, constipation, heartburn 2.1 3.6 7.3 -2.7 1.7 -0.6
Neck or shoulder pain in last month 0.0 0.0 0.0 0.1 0.2 0.0
Medication: Blood pressure 0.9 1.6 2.7 1.4 -1.6 0.0
Angina (self-reported) 1.5 2.0 2.8 -1.7 -1.1 -1.4
Migraine (self-reported) 2.8 3.5 3.7 1.9 -1.8 1.9
Medication: Ibuprofen 1.3 1.6 2.2 1.0 -1.5 1.3
Medication: Allopurinol 0.3 0.4 1.1 0.0 -1.0 0.3
Medication: Omeprazole 2.0 2.4 6.5 0.6 2.5 0.6
Medication: Seretide 50 evohaler 0.7 0.7 1.3 -1.2 -0.1 -1.0
Mean time to correctly identify matches 0.5 0.9 1.3 0.8 1.0 1.1
Heart disease (mother) 0.9 1.1 3.1 1.8 -0.4 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.4 0.1 0.5 0.7
Whole body fat mass 0.7 3.0 4.6 1.6 -1.3 -2.1
Leg fat mass (right) 0.6 2.3 3.5 1.7 -0.8 -1.9
Arm predicted mass (right) 0.7 3.5 5.5 -0.5 -2.2 -2.3
Pulse rate, automated reading 0.0 0.0 0.1 -0.2 -0.2 -0.2
Alcohol intake frequency. 0.4 0.9 2.3 0.5 0.2 1.5
Comparative height size at age 10 0.9 4.8 6.9 2.6 -1.2 2.5
Number of full sisters 0.8 0.9 1.7 -0.0 1.3 -1.1
Suffer from ‘nerves’ 6.0 9.5 22.3 4.7 -0.6 2.4
Overall health rating 0.0 0.1 0.1 0.3 0.2 -0.4
Chest pain or discomfort 0.0 0.1 0.1 -0.4 -0.3 -0.0
Had major operations 0.9 1.0 2.6 -1.6 -0.4 0.6
Age at last live birth 0.8 1.2 2.0 -0.5 -1.2 1.4
Family relationship satisfaction 1.0 1.2 3.0 0.7 1.7 -0.4
Leg pain on walking 1.4 1.8 3.2 1.1 -1.0 1.8
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 0.8 -0.9 -0.6 -0.6
Commuting to job workplace: Car/motor vehicle 2.1 2.4 3.7 -1.9 -0.1 -1.9
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.1 0.0 -0.0 -0.3
Medication: Aspirin 0.8 1.0 2.0 1.4 -1.0 -0.3
Supplements: Vitamin C 0.9 1.1 1.9 1.4 0.9 0.7
Knee pain experienced in last month 0.5 0.8 2.2 -1.5 0.3 0.2
Hypertension (Self-reported) 1.7 4.7 11.8 3.4 -1.5 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.6 -0.8 -0.2 -0.4
Illnesses of father: Heart disease 0.2 0.2 0.6 0.8 0.1 -0.3
Illnesses of siblings: Diabetes 0.1 0.1 0.3 0.6 -0.2 0.1
Smoking status: Previous 0.5 0.7 1.0 0.7 -1.0 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 2.9 -1.7 0.6 -0.9
Whole body fat-free mass 0.7 4.1 6.4 -0.5 -2.5 -2.4
Leg fat-free mass (right) 0.7 3.8 8.3 0.3 -2.9 -1.7
Arm fat percentage (left) 0.6 2.3 4.8 2.2 -0.9 -1.0
Average weekly red wine intake 1.0 1.4 2.4 0.6 -1.6 1.2
Handedness (chirality/laterality): Left-handed 0.9 1.1 2.4 1.6 0.9 0.4
Mood swings 0.6 1.1 1.9 0.6 -1.0 1.4
Loneliness, isolation 1.9 2.7 5.7 2.4 0.2 1.5
Long-standing illness, disability or infirmity 1.0 1.5 2.8 -0.7 -1.1 -1.7
Ever had bowel cancer screening 0.2 0.2 0.6 -0.1 0.3 -0.8
Diabetes diagnosed by doctor 0.8 1.3 2.2 1.5 -1.3 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 2.0 0.5 -1.4 -1.3
Friendships satisfaction 0.3 0.4 0.7 0.8 0.7 0.1
Qualifications: nursing, teaching 0.6 0.9 1.2 1.1 -0.7 -1.1
Commuting to job workplace: Walk 1.3 1.4 2.0 0.8 1.2 1.4
Eye problems/disorders: Cataract 0.2 0.2 0.3 -0.4 -0.5 -0.4
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 4.6 -2.2 0.3 -0.3
Medication for cholesterol 1.3 2.0 5.4 -2.3 -0.3 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 2.3 1.5 -0.9 0.3
Back pain experienced in last month 3.7 5.4 8.1 -2.8 -2.8 -0.7
Mineral and other dietary supplements 0.8 1.0 2.8 -1.7 -0.5 -0.3
Breast cancer (self-reported) 2.7 3.2 6.4 1.2 2.5 1.4
Asthma (self-reported) 3.6 7.1 13.9 -2.1 -3.7 -1.8
Osteoporosis (self-reported) 0.4 0.5 1.3 0.2 -1.1 0.0
Osteoarthritis (self-reported) 0.0 0.1 0.1 0.4 0.0 0.1
Medication: Aspirin 0.7 0.9 1.7 1.3 -0.8 -0.4
Medication: Gliclazide 1.9 2.1 3.8 0.4 -1.5 -2.0
Illnesses of father: None of the above (group 1) 0.6 0.7 1.1 0.3 1.0 0.9
Smoking status: Current 0.8 1.3 3.6 -0.3 1.9 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 2.6 -0.7 1.6 1.6
Whole body water mass 0.7 3.9 6.0 -0.5 -2.5 -2.3
Leg predicted mass (right) 0.7 4.0 8.6 0.2 -2.9 -1.8
Arm fat mass (left) 0.6 2.5 3.4 1.5 -1.4 -1.8
Number of self-reported non-cancer illnesses 2.1 3.7 10.0 3.2 -0.1 1.0
Average weekly champagne plus white wine intake 0.9 1.2 2.0 -1.4 -1.0 -0.9
Miserableness 0.1 0.2 0.4 -0.3 -0.1 -0.6
Guilty feelings 1.4 2.1 2.4 1.5 -1.6 1.3
Wears glasses or contact lenses 0.5 0.5 1.4 1.2 -0.3 -0.2
Ever taken oral contraceptive pill 4.0 4.4 9.9 -1.6 -0.8 -3.2
Hearing aid user 0.8 0.9 2.2 0.7 0.1 1.5
Mother’s age at death 2.1 2.6 5.7 -2.4 0.8 -1.2
Financial situation satisfaction 0.0 0.0 0.1 -0.2 0.2 -0.0
Tinnitus: Yes, now most or all of the time 0.9 1.1 2.2 1.5 0.6 0.9
Commuting to job workplace: Public transport 0.7 0.9 1.3 1.2 -0.2 1.1
Eye problems/disorders: Glaucoma 1.4 1.7 4.2 -0.1 -2.1 -0.9
Medication: Blood pressure 1.8 3.4 9.5 3.1 -0.8 -0.1
Pain type(s) experienced in last month: Hip pain 0.7 0.8 1.6 1.3 0.4 -0.9
Supplements: Fish oil (including cod liver oil) 1.5 2.0 5.9 2.4 -0.0 0.3
High cholesterol (Self-reported) 0.6 1.1 2.2 1.5 0.4 -0.9
Medication: Bendroflumethiazide 1.9 2.9 6.5 2.5 0.1 1.5
Medication: Paracetamol 0.2 0.3 0.7 0.4 0.8 0.1
Medication: Lisinopril 1.1 1.4 4.2 2.0 -0.3 -0.2
Medication: Atorvastatin 2.7 3.4 5.1 2.2 -0.5 2.3
Illnesses of father: High blood pressure 1.7 2.1 3.7 1.9 -1.3 0.9
Alcohol drinker status: Never 0.3 0.4 0.8 0.6 0.1 0.9
Ever smoked 0.7 1.3 3.1 1.8 0.8 -0.4
Basal metabolic rate 0.8 4.2 6.8 -0.3 -2.4 -2.6
Leg fat percentage (left) 0.6 2.1 4.1 2.0 0.5 -1.4
Arm fat-free mass (left) 0.8 3.9 7.6 -0.5 -2.0 -2.8
Number of operations (self-reported) 0.2 0.3 0.6 -0.4 -0.8 0.4
Average weekly beer plus cider intake 0.6 0.8 1.9 -0.7 -1.4 0.3
Irritability 1.1 1.9 2.5 1.3 1.2 1.6
Risk taking 0.0 0.1 0.2 -0.4 -0.1 -0.1
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.4 0.6 -0.4 0.6
Fractured/broken bones in last 5 years 0.2 0.3 0.8 -0.9 0.2 -0.2
Age started oral contraceptive pill 0.9 1.1 1.8 0.8 1.3 -1.0
Diastolic blood pressure, automated reading 0.6 2.0 3.4 1.5 -1.8 0.6
Ever depressed for a whole week 0.2 0.2 0.6 -0.3 0.2 -0.8
Unable to work because of sickness or disability 1.5 2.0 4.5 0.7 1.0 2.1
Commuting to job workplace: Cycle 1.1 1.4 3.0 -0.8 1.7 0.7
Myopia 2.2 3.2 5.6 1.8 0.8 2.4
Vascular/heart problems diagnosed by doctor 1.5 4.0 10.2 -3.2 1.3 -0.5
Cholesterol lowering medication 0.9 1.3 2.9 1.7 0.9 -0.0
Medication: Omeprazole (e.g. Zanprol) 2.6 3.1 6.8 1.0 2.6 1.3
Pain experienced in last month 0.4 0.7 1.4 0.7 1.2 0.4
Supplements: Calcium 0.4 0.4 0.9 0.0 -1.0 0.5
Basal cell carcinoma (self-reported) 1.7 2.0 3.2 -1.8 0.8 -1.5
Heart attack/myocardial infarction (self-reported) 1.4 1.8 3.6 -1.0 -1.9 -0.9
Deep venous thrombosis (DVT) (self-reported) 2.0 2.6 4.1 2.0 -1.4 1.4
Heart disease (siblings) 0.2 0.3 0.6 0.4 -0.8 -0.3
Alcohol drinker status: Previous 0.5 0.5 1.5 1.2 0.3 -0.1
Pack years of smoking 1.0 1.5 3.1 1.8 0.4 1.1
Impedance of whole body 0.2 0.9 2.8 -0.0 1.7 -0.2
Leg fat mass (left) 0.6 2.2 3.6 1.6 -0.6 -1.9
Arm predicted mass (left) 0.7 3.3 6.5 -0.4 -1.8 -2.6