TWAS hub - ANXA2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.1725	0.0266	0.00000	0.137	0.124	0.150	0.143	0.147	1.2e-42	2.3e-38	1.0e-46	2.7e-44	1.4e-45
2	TCGA	Lung Squamous Cell Carcinoma	0.0379	0.0168	0.00067	0.041	0.035	0.043	NA	0.044	1.8e-05	6.2e-05	1.1e-05	NA	9.0e-06
3	TCGA	Prostate Adenocarcinoma	0.1389	0.0573	0.00170	0.039	0.044	0.045	NA	0.049	6.2e-05	2.2e-05	1.7e-05	NA	7.5e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Age when periods started (menarche)	12.1	29.0	42.3	-6.3	-2.2	-6.5
Relative age voice broke	11.3	17.2	28.6	-4.8	-0.3	-5.3
Relative age of first facial hair	10.7	22.1	34.5	-5.9	-1.4	-5.5
Suffer from ‘nerves’	6.0	9.5	22.3	4.7	-0.6	2.4
Father’s age at death	5.9	7.9	18.6	-2.1	-0.8	-4.3
Pain all over the body in last month	5.0	5.3	7.2	1.9	2.3	2.7
Nervous feelings	4.8	9.0	13.9	3.7	1.4	3.3
Depression (self-reported)	4.8	5.8	8.9	3.0	1.5	2.5
Mean Putamen Volume	4.4	5.0	9.9	-2.1	-0.8	-3.1
Ever taken oral contraceptive pill	4.0	4.4	9.9	-1.6	-0.8	-3.2
Back pain experienced in last month	3.7	5.4	8.1	-2.8	-2.8	-0.7
Vitamin and mineral supplements	3.6	4.9	10.9	-3.3	0.7	-1.8
Asthma (self-reported)	3.6	7.1	13.9	-2.1	-3.7	-1.8
Worry (Nagel 2018)	3.5	7.4	13.2	3.6	0.4	3.0
Asthma	3.5	7.0	12.5	-2.2	-3.5	-1.9
Neuroticism (2016)	3.4	4.9	8.2	2.9	-0.6	2.5
Bilateral oophorectomy (both ovaries removed)	3.4	3.9	7.6	1.9	0.5	2.8
Multivitamins +/- minerals	3.4	4.3	7.6	2.8	-1.5	1.7
Medication: Ventolin 100micrograms inhaler	3.4	4.3	6.7	-2.1	-2.6	-1.4
Tense / ‘highly strung’	3.3	5.5	9.0	3.0	0.4	2.7
Time employed in main current job	3.2	3.7	9.2	3.0	-0.1	1.4
Migraine (self-reported)	2.8	3.5	3.7	1.9	-1.8	1.9
Ever had hysterectomy (womb removed)	2.7	3.0	3.5	1.9	1.9	1.4
Breast cancer (self-reported)	2.7	3.2	6.4	1.2	2.5	1.4
Medication: Atorvastatin	2.7	3.4	5.1	2.2	-0.5	2.3
Respiratory disease	2.6	5.8	6.4	-2.5	-2.5	-2.2
Medication: Omeprazole (e.g. Zanprol)	2.6	3.1	6.8	1.0	2.6	1.3
Hearing difficulty/problems with background noise	2.5	3.9	8.1	1.3	1.4	2.8
Seen a psychiatrist for nerves, anxiety, tension or depression	2.5	3.2	5.8	2.4	1.4	1.3
Frequency of tenseness / restlessness in last 2 weeks	2.4	3.8	8.5	1.3	1.0	2.9
Medication: Ibuprofen (e.g. Nurofen)	2.4	3.1	5.6	1.3	-2.4	1.4
Neuroticism	2.3	5.5	10.9	2.4	0.2	3.3
Neuroticism score	2.3	4.9	8.3	2.5	-0.3	2.9
Prospective memory result	2.3	2.8	4.4	-2.1	-1.6	-1.2
Length of working week for main job	2.3	2.6	7.4	0.6	-2.7	-0.0
Other serious medical condition/disability diagnosed by doctor	2.2	2.8	4.6	2.1	0.2	1.9
Taking other prescription medications	2.2	3.3	7.7	2.8	-1.5	-0.4
Blood clot in the leg (DVT)	2.2	2.9	4.4	2.1	-1.6	1.2
Myopia	2.2	3.2	5.6	1.8	0.8	2.4
Hearing difficulty/problems: Yes	2.1	3.2	7.1	1.3	-0.9	2.7
Mouth/teeth dental problems: Loose teeth	2.1	2.6	4.9	1.4	2.2	0.9
Medication for pain relief, constipation, heartburn	2.1	3.6	7.3	-2.7	1.7	-0.6
Commuting to job workplace: Car/motor vehicle	2.1	2.4	3.7	-1.9	-0.1	-1.9
Number of self-reported non-cancer illnesses	2.1	3.7	10.0	3.2	-0.1	1.0
Mother’s age at death	2.1	2.6	5.7	-2.4	0.8	-1.2
Age at First Birth	2.0	2.9	6.3	-1.0	-2.5	-1.2
Mouth/teeth dental problems: Dentures	2.0	3.4	5.3	1.8	1.2	2.3
Medication: Omeprazole	2.0	2.4	6.5	0.6	2.5	0.6
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	4.1	2.0	-1.4	1.4
Ever used hormone-replacement therapy (HRT)	1.9	2.4	6.1	2.5	0.3	1.1
Mouth/teeth dental problems	1.9	2.8	4.7	-0.2	-2.2	-1.9
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	6.5	-0.7	-2.5	-0.7
Birth weight	1.9	4.2	9.4	-1.7	-0.2	-3.1
Loneliness, isolation	1.9	2.7	5.7	2.4	0.2	1.5
Medication: Gliclazide	1.9	2.1	3.8	0.4	-1.5	-2.0
Medication: Bendroflumethiazide	1.9	2.9	6.5	2.5	0.1	1.5
Neuroticism (Nagel 2018)	1.8	4.3	7.6	2.8	0.4	2.3
Primary Biliary Cirrhosis	1.8	2.6	3.3	1.8	-1.6	1.3
Average weekly fortified wine intake	1.8	2.1	4.6	-2.1	0.2	-1.3
High blood pressure	1.8	5.0	13.5	3.7	-1.1	0.6
Medication: Blood pressure	1.8	3.4	9.5	3.1	-0.8	-0.1
Schizophrenia (2014)	1.7	3.6	6.6	-1.7	1.2	-2.6
Waist Hip Ratio (WHR)	1.7	7.7	13.0	2.9	-1.3	3.6
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.8	7.3	2.7	-0.5	2.0
Hypertension (Self-reported)	1.7	4.7	11.8	3.4	-1.5	0.5
Illnesses of father: High blood pressure	1.7	2.1	3.7	1.9	-1.3	0.9
Basal cell carcinoma (self-reported)	1.7	2.0	3.2	-1.8	0.8	-1.5
Had menopause	1.6	2.1	4.5	2.1	0.9	1.0
Comparative body size at age 10	1.6	4.4	10.1	3.2	-1.1	1.4
Angina (self-reported)	1.5	2.0	2.8	-1.7	-1.1	-1.4
Supplements: Fish oil (including cod liver oil)	1.5	2.0	5.9	2.4	-0.0	0.3
Unable to work because of sickness or disability	1.5	2.0	4.5	0.7	1.0	2.1
Vascular/heart problems diagnosed by doctor	1.5	4.0	10.2	-3.2	1.3	-0.5
Heart attack	1.4	1.8	3.8	-0.9	-2.0	-0.8
Leg pain on walking	1.4	1.8	3.2	1.1	-1.0	1.8
Guilty feelings	1.4	2.1	2.4	1.5	-1.6	1.3
Eye problems/disorders: Glaucoma	1.4	1.7	4.2	-0.1	-2.1	-0.9
Heart attack/myocardial infarction (self-reported)	1.4	1.8	3.6	-1.0	-1.9	-0.9
Major Depression (MDD)	1.3	1.6	4.1	0.6	2.0	0.6
Medication for hormone replacement therapy	1.3	1.4	3.6	0.2	0.8	1.9
Hand grip strength (right)	1.3	3.4	4.6	-1.6	-1.7	-2.1
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	4.9	2.2	0.1	2.0
Diabetes (self-reported)	1.3	2.0	5.2	2.3	-0.6	0.7
Wheeze or whistling in the chest in last year	1.3	2.3	6.1	-0.3	-2.5	-0.8
Medication: Ibuprofen	1.3	1.6	2.2	1.0	-1.5	1.3
Commuting to job workplace: Walk	1.3	1.4	2.0	0.8	1.2	1.4
Medication for cholesterol	1.3	2.0	5.4	-2.3	-0.3	-0.8
Angina	1.2	1.6	2.2	-1.3	-1.0	-1.5
Hair/balding pattern: Pattern 2	1.2	1.6	4.2	2.1	-0.2	0.6
Peak expiratory flow (PEF)	1.2	2.9	5.1	0.0	-1.9	2.3
Ever highly irritable/argumentative for 2 days	1.2	1.5	3.0	1.7	0.2	1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.0	0.5	-1.4	-1.3
Number of treatments/medications taken	1.1	2.0	5.8	2.4	-0.5	-0.0
Sensitivity / hurt feelings	1.1	1.9	3.1	1.6	-0.0	1.8
Diabetes (father)	1.1	1.3	3.2	0.4	-1.8	0.8
Pack years adult smoking proportion	1.1	1.6	2.4	1.5	0.4	1.6
Hip circumference	1.1	4.7	9.8	0.3	-2.0	-3.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	3.9	2.0	-0.1	1.0
Exposure to tobacco smoke outside home	1.1	1.4	3.6	-1.9	0.7	0.2
Medication: Lisinopril	1.1	1.4	4.2	2.0	-0.3	-0.2
Irritability	1.1	1.9	2.5	1.3	1.2	1.6
Commuting to job workplace: Cycle	1.1	1.4	3.0	-0.8	1.7	0.7
Schizophrenia (2018)	1.0	2.1	4.7	-0.6	1.0	-2.2
Rheumatoid Arthritis	1.0	1.4	1.9	1.3	1.4	0.7
Ulcerative Colitis	1.0	1.4	1.9	-1.1	1.4	-1.1
Lung FEV1/FVC ratio	1.0	5.2	11.0	-0.3	3.3	2.1
Allergy	1.0	2.4	5.8	0.5	2.4	1.0
Breastfed as a baby	1.0	1.2	2.4	-1.0	1.5	0.5
Family relationship satisfaction	1.0	1.2	3.0	0.7	1.7	-0.4
Average weekly red wine intake	1.0	1.4	2.4	0.6	-1.6	1.2
Long-standing illness, disability or infirmity	1.0	1.5	2.8	-0.7	-1.1	-1.7
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	4.6	-2.2	0.3	-0.3
Pack years of smoking	1.0	1.5	3.1	1.8	0.4	1.1
Crohns Disease (2012)	0.9	1.5	3.4	-0.8	-0.8	-1.8
Blood Eosinophil Count	0.9	7.0	18.5	-4.3	-0.1	-1.6
Cardiovascular Disease	0.9	2.9	6.7	2.6	-0.7	-1.2
Hand grip strength (left)	0.9	2.4	3.3	-1.1	-1.6	-1.8
Severe depression (siblings)	0.9	1.0	1.5	1.2	0.8	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.3	1.1	-0.0	1.5
Medication: Cholesterol lowering	0.9	1.4	2.7	1.6	-1.2	0.3
Emphysema/chronic bronchitis	0.9	1.0	1.9	-0.6	1.4	0.9
Medication: Blood pressure	0.9	1.6	2.7	1.4	-1.6	0.0
Heart disease (mother)	0.9	1.1	3.1	1.8	-0.4	-0.2
Comparative height size at age 10	0.9	4.8	6.9	2.6	-1.2	2.5
Had major operations	0.9	1.0	2.6	-1.6	-0.4	0.6
Supplements: Vitamin C	0.9	1.1	1.9	1.4	0.9	0.7
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.4	1.6	0.9	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.3	1.5	-0.9	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	2.6	-0.7	1.6	1.6
Average weekly champagne plus white wine intake	0.9	1.2	2.0	-1.4	-1.0	-0.9
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.2	1.5	0.6	0.9
Age started oral contraceptive pill	0.9	1.1	1.8	0.8	1.3	-1.0
Cholesterol lowering medication	0.9	1.3	2.9	1.7	0.9	-0.0
Breast Cancer	0.8	1.8	5.4	-0.3	-2.3	0.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.8	0.9	-0.3	1.3
Blood White Count	0.8	5.7	8.8	3.0	-2.3	1.8
Systolic Blood Pressure	0.8	4.1	6.8	2.6	-2.3	-0.4
Leg fat-free mass (left)	0.8	4.1	7.5	0.1	-2.7	-2.2
Maternal smoking around birth	0.8	1.1	1.5	-1.2	1.1	-0.8
Medication: Levothyroxine sodium	0.8	1.3	2.2	1.5	0.4	-1.3
Leg predicted mass (left)	0.8	4.0	7.4	0.2	-2.7	-2.2
Waist circumference	0.8	3.0	4.5	2.1	-2.1	-0.5
Worrier / anxious feelings	0.8	1.5	3.0	1.1	-0.6	1.7
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	3.3	0.7	-0.5	1.8
Illnesses of mother	0.8	1.0	2.9	-0.1	0.2	1.7
Hair/balding pattern: Pattern 4	0.8	2.0	4.6	-1.1	-0.2	2.1
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.2	0.5	0.9	1.5
High blood pressure (siblings)	0.8	1.1	2.6	-0.6	-0.6	-1.6
Worry too long after embarrassment	0.8	1.4	3.3	0.9	0.0	1.8
Number of full sisters	0.8	0.9	1.7	-0.0	1.3	-1.1
Age at last live birth	0.8	1.2	2.0	-0.5	-1.2	1.4
Medication: Aspirin	0.8	1.0	2.0	1.4	-1.0	-0.3
Diabetes diagnosed by doctor	0.8	1.3	2.2	1.5	-1.3	-0.1
Mineral and other dietary supplements	0.8	1.0	2.8	-1.7	-0.5	-0.3
Smoking status: Current	0.8	1.3	3.6	-0.3	1.9	0.5
Hearing aid user	0.8	0.9	2.2	0.7	0.1	1.5
Basal metabolic rate	0.8	4.2	6.8	-0.3	-2.4	-2.6
Arm fat-free mass (left)	0.8	3.9	7.6	-0.5	-2.0	-2.8
Fasting Glucose	0.7	0.8	2.3	-0.3	0.1	1.5
HbA1C	0.7	0.8	1.9	1.4	0.4	-0.4
Height	0.7	13.9	27.5	-3.1	-2.2	-5.2
Hypothyroidism (self reported)	0.7	1.6	4.5	2.1	0.5	-0.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.7	1.2	-1.3	0.1
Systolic blood pressure, automated reading	0.7	2.0	4.3	2.1	-1.3	0.3
Medication: Co-codamol	0.7	0.8	1.5	1.0	0.0	-1.2
Diabetes (mother)	0.7	0.9	1.7	1.3	-1.0	-0.0
Trunk fat percentage	0.7	2.6	4.0	2.0	-0.6	-1.9
Serious illness, injury or assault to yourself	0.7	0.8	1.7	1.3	0.7	-0.5
Trunk fat mass	0.7	3.1	5.7	1.4	-1.2	-2.4
Weight	0.7	3.4	7.5	0.4	-1.6	-2.7
Trunk fat-free mass	0.7	3.8	6.2	-1.0	-2.1	-2.5
Trunk predicted mass	0.7	3.8	6.1	-1.0	-2.1	-2.5
Standing height	0.7	6.7	12.2	-2.3	-1.6	-3.5
Glaucoma (self-reported)	0.7	0.8	1.5	0.4	-1.2	-0.8
Leg fat percentage (right)	0.7	2.4	4.3	2.1	0.4	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.8	0.2	1.4	0.7
Age at first live birth	0.7	1.2	2.1	-1.4	-0.9	0.8
Medication: Seretide 50 evohaler	0.7	0.7	1.3	-1.2	-0.1	-1.0
Whole body fat mass	0.7	3.0	4.6	1.6	-1.3	-2.1
Arm predicted mass (right)	0.7	3.5	5.5	-0.5	-2.2	-2.3
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.9	-1.7	0.6	-0.9
Whole body fat-free mass	0.7	4.1	6.4	-0.5	-2.5	-2.4
Leg fat-free mass (right)	0.7	3.8	8.3	0.3	-2.9	-1.7
Medication: Aspirin	0.7	0.9	1.7	1.3	-0.8	-0.4
Whole body water mass	0.7	3.9	6.0	-0.5	-2.5	-2.3
Leg predicted mass (right)	0.7	4.0	8.6	0.2	-2.9	-1.8
Commuting to job workplace: Public transport	0.7	0.9	1.3	1.2	-0.2	1.1
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.6	1.3	0.4	-0.9
Ever smoked	0.7	1.3	3.1	1.8	0.8	-0.4
Arm predicted mass (left)	0.7	3.3	6.5	-0.4	-1.8	-2.6
Ovarian Cancer	0.6	0.8	1.5	-0.0	-0.9	-1.2
Coronary Artery Disease (CAD)	0.6	0.7	1.3	-1.1	0.8	-0.3
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.8	1.7	-0.9	-0.2
Supplements: Zinc	0.6	0.7	0.9	1.0	0.3	1.0
Impedance of leg (right)	0.6	2.7	6.8	-0.5	2.6	-1.0
Current tobacco smoking	0.6	1.0	2.8	-0.2	1.7	0.4
Medication: Lansoprazole	0.6	0.7	2.0	1.4	-0.2	-0.0
Arm fat mass (right)	0.6	2.5	4.5	1.3	-1.1	-2.1
Birth weight of first child	0.6	1.1	2.3	-0.9	-0.2	-1.5
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.7	-1.3	1.1	-0.0
Body fat percentage	0.6	2.5	4.5	2.1	-0.4	-1.7
Arm fat-free mass (right)	0.6	2.9	4.7	-0.3	-2.2	-2.0
Leg fat mass (right)	0.6	2.3	3.5	1.7	-0.8	-1.9
Arm fat percentage (left)	0.6	2.3	4.8	2.2	-0.9	-1.0
Mood swings	0.6	1.1	1.9	0.6	-1.0	1.4
Qualifications: nursing, teaching	0.6	0.9	1.2	1.1	-0.7	-1.1
Illnesses of father: None of the above (group 1)	0.6	0.7	1.1	0.3	1.0	0.9
Arm fat mass (left)	0.6	2.5	3.4	1.5	-1.4	-1.8
High cholesterol (Self-reported)	0.6	1.1	2.2	1.5	0.4	-0.9
Leg fat percentage (left)	0.6	2.1	4.1	2.0	0.5	-1.4
Average weekly beer plus cider intake	0.6	0.8	1.9	-0.7	-1.4	0.3
Diastolic blood pressure, automated reading	0.6	2.0	3.4	1.5	-1.8	0.6
Leg fat mass (left)	0.6	2.2	3.6	1.6	-0.6	-1.9
Bipolar Disorder or Schizophrenia	0.5	1.3	3.1	-0.6	0.7	-1.8
Chronotype (morning person)	0.5	1.3	2.6	-1.0	1.6	-0.3
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.1	-0.7	-1.8	-0.1
Medication: Atenolol	0.5	0.7	1.3	1.2	0.8	0.2
Sitting height	0.5	3.7	7.7	-2.8	-1.2	-1.4
Impedance of leg (left)	0.5	2.5	7.0	-0.3	2.6	-0.7
Number of incorrect matches in round	0.5	0.9	1.7	0.7	-0.6	1.3
Forced vital capacity (FVC)	0.5	1.9	3.5	-1.9	-1.5	-0.0
Arm fat percentage (right)	0.5	2.0	3.8	2.0	-0.4	-1.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	4.5	-2.1	-0.6	0.5
Noisy workplace	0.5	0.6	1.3	0.6	1.2	0.2
Pulse wave reflection index	0.5	0.6	1.2	0.8	-1.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.7	1.6	0.2	-0.6
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	-1.0	-0.2	-0.7
Mean time to correctly identify matches	0.5	0.9	1.3	0.8	1.0	1.1
Knee pain experienced in last month	0.5	0.8	2.2	-1.5	0.3	0.2
Smoking status: Previous	0.5	0.7	1.0	0.7	-1.0	-0.8
Wears glasses or contact lenses	0.5	0.5	1.4	1.2	-0.3	-0.2
Alcohol drinker status: Previous	0.5	0.5	1.5	1.2	0.3	-0.1
Schizophrenia vs Biploar Disorder	0.4	0.5	1.1	-0.3	1.0	-0.7
Alzheimer’s Disease (in father)	0.4	0.4	0.6	0.7	-0.7	-0.5
Prostate Cancer	0.4	0.5	1.2	-1.1	0.3	0.5
LDL Cholesterol	0.4	0.6	1.1	0.0	-1.1	0.9
BMI	0.4	2.4	5.3	2.3	-0.2	-1.3
Allergy or Eczema	0.4	1.0	2.7	-0.4	-1.6	-0.4
Lung FVC	0.4	2.0	3.6	-1.5	-0.3	1.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.3	-0.1	-1.1	-0.3
Fed-up feelings	0.4	0.8	0.9	1.0	-0.9	0.7
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.4	0.1	-1.2	0.2
Body mass index (BMI)	0.4	1.6	1.9	1.4	-1.0	-1.3
Past tobacco smoking	0.4	0.8	2.1	-1.4	-0.2	0.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	0.8	0.9	-0.1	0.7
Medication: Ramipril	0.4	0.5	1.4	-0.4	-1.2	-0.0
Medication: Simvastatin	0.4	0.5	0.9	1.0	-0.1	-0.8
Gout (self-reported)	0.4	0.6	1.1	-0.5	-1.1	0.5
Number of children fathered	0.4	0.5	0.8	-0.4	-0.9	-0.6
Pulse wave peak to peak time	0.4	0.4	0.6	-0.6	0.5	-0.8
Health satisfaction	0.4	0.5	1.2	-0.1	1.1	-0.5
Shortness of breath walking on level ground	0.4	0.5	1.2	0.2	1.1	0.5
Alcohol intake frequency.	0.4	0.9	2.3	0.5	0.2	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.8	-0.9	-0.6	-0.6
Osteoporosis (self-reported)	0.4	0.5	1.3	0.2	-1.1	0.0
Pain experienced in last month	0.4	0.7	1.4	0.7	1.2	0.4
Supplements: Calcium	0.4	0.4	0.9	0.0	-1.0	0.5
Depressed Affect (Nagel 2018)	0.3	0.6	1.5	0.5	0.3	1.2
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	-0.4	-0.5	-0.8
Alzheimer’s Disease (including proxy)	0.3	0.4	0.6	-0.3	-0.7	-0.7
Irritable Bowel Disease (IBD)	0.3	0.8	1.8	0.1	0.8	-1.3
Ulcerative Colitis (UC)	0.3	0.6	1.1	-0.4	0.7	-1.1
Bipolar Disorder (2011)	0.3	0.2	0.6	-0.2	0.8	-0.1
Smoking Status	0.3	0.8	1.7	-0.4	1.3	-0.7
Qualifications: CSEs or equivalent	0.3	0.4	0.5	-0.6	-0.6	-0.7
High blood pressure (mother)	0.3	0.5	0.9	1.0	0.7	-0.1
Financial difficulties in last 2 years	0.3	0.4	0.5	-0.5	-0.6	-0.7
Illnesses of siblings	0.3	0.4	1.0	-0.2	-0.3	1.0
Falls in the last year	0.3	0.4	0.9	-0.9	-0.3	0.3
Number of live births	0.3	0.4	1.0	0.1	-0.2	-1.0
Pulse wave Arterial Stiffness index	0.3	0.4	0.5	0.5	-0.7	0.7
Headache pain in last month	0.3	0.5	0.9	1.0	-0.8	0.3
Medication: Allopurinol	0.3	0.4	1.1	0.0	-1.0	0.3
Friendships satisfaction	0.3	0.4	0.7	0.8	0.7	0.1
Alcohol drinker status: Never	0.3	0.4	0.8	0.6	0.1	0.9
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.4	0.6	-0.4	0.6
Depression (Nagel 2018)	0.2	0.3	0.9	0.9	-0.2	0.1
Crohns Disease (2017)	0.2	0.4	1.1	0.4	0.0	-1.0
Reaction Time	0.2	0.3	0.6	-0.6	0.7	0.4
Triglycerides	0.2	0.4	0.7	-0.1	-0.8	-0.6
Blood Platelet Count	0.2	2.9	3.9	-1.4	1.6	-2.0
Blood Red Count	0.2	1.5	3.0	1.2	0.1	1.7
Hair Pigment	0.2	4.4	10.9	1.3	-3.3	-0.7
Townsend deprivation index at recruitment	0.2	0.2	0.6	0.8	-0.0	0.1
Stomach or abdominal pain in last month	0.2	0.2	0.3	-0.5	0.5	-0.4
Alcohol usually taken with meals	0.2	0.3	0.8	-0.0	-0.9	-0.4
Fluid intelligence score	0.2	0.4	0.8	-0.6	0.9	0.4
Happiness	0.2	0.2	0.7	-0.8	-0.2	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.0	-1.4	-0.2	0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.8	0.9	-0.3	0.5
Forced vital capacity (FVC), Best measure	0.2	0.8	1.3	-1.2	-1.0	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	0.1	0.5	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.6	-0.8	-0.2	-0.4
Illnesses of father: Heart disease	0.2	0.2	0.6	0.8	0.1	-0.3
Ever had bowel cancer screening	0.2	0.2	0.6	-0.1	0.3	-0.8
Eye problems/disorders: Cataract	0.2	0.2	0.3	-0.4	-0.5	-0.4
Medication: Paracetamol	0.2	0.3	0.7	0.4	0.8	0.1
Number of operations (self-reported)	0.2	0.3	0.6	-0.4	-0.8	0.4
Fractured/broken bones in last 5 years	0.2	0.3	0.8	-0.9	0.2	-0.2
Ever depressed for a whole week	0.2	0.2	0.6	-0.3	0.2	-0.8
Heart disease (siblings)	0.2	0.3	0.6	0.4	-0.8	-0.3
Impedance of whole body	0.2	0.9	2.8	-0.0	1.7	-0.2
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.6	0.5	0.1	0.8
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	0.2	0.6	0.4
Body Mass Index (BMI) (2010)	0.1	0.2	0.3	0.1	-0.4	-0.6
HDL Cholesterol	0.1	0.1	0.2	0.1	0.3	-0.5
Lupus	0.1	0.1	0.2	0.3	0.4	0.1
Heel T-Score	0.1	0.7	1.3	1.1	-0.8	-0.4
Average weekly spirits intake	0.1	0.1	0.2	0.1	-0.2	-0.5
Medication: Metformin	0.1	0.2	0.3	0.6	-0.0	-0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.1	0.3	0.4
Supplements: Glucosamine	0.1	0.1	0.2	-0.4	-0.0	0.2
Had other major operations	0.1	0.1	0.2	-0.2	0.5	-0.2
Impedance of arm (right)	0.1	0.6	1.7	0.4	1.3	-0.0
Alcohol intake versus 10 years previously	0.1	0.1	0.3	-0.5	-0.1	-0.0
Hair/balding pattern: Pattern 3	0.1	0.1	0.1	0.3	-0.2	-0.3
Pulse rate	0.1	0.2	0.5	0.0	0.7	0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	0.4	0.5	0.2
Lung cancer (father)	0.1	0.2	0.4	0.2	0.1	-0.6
Impedance of arm (left)	0.1	0.4	0.7	0.5	0.8	0.6
Exposure to tobacco smoke at home	0.1	0.2	0.4	-0.2	0.6	-0.2
Loud music exposure frequency	0.1	0.1	0.1	-0.3	0.2	0.3
Medication: Paracetamol	0.1	0.2	0.5	0.7	-0.4	-0.2
Medication: Amlodipine	0.1	0.1	0.1	-0.3	-0.4	-0.2
Illnesses of siblings: Diabetes	0.1	0.1	0.3	0.6	-0.2	0.1
Miserableness	0.1	0.2	0.4	-0.3	-0.1	-0.6
Bipolar Disorder (2018)	0.0	0.0	0.0	-0.1	-0.1	-0.1
Tanning	0.0	0.2	0.4	-0.5	0.3	-0.6
Chronic bronchitis/emphysema (father)	0.0	0.1	0.1	0.4	0.1	-0.2
Qualifications: None of the above	0.0	0.1	0.2	-0.4	0.1	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	0.2	0.1	-0.2
Number of full brothers	0.0	0.0	0.0	-0.2	0.1	-0.1
Qualifications: College or University degree	0.0	0.1	0.2	-0.4	0.3	0.3
Eye problems/disorders: None of the above	0.0	0.0	0.0	0.0	0.1	0.1
Neck or shoulder pain in last month	0.0	0.0	0.0	0.1	0.2	0.0
Pulse rate, automated reading	0.0	0.0	0.1	-0.2	-0.2	-0.2
Overall health rating	0.0	0.1	0.1	0.3	0.2	-0.4
Chest pain or discomfort	0.0	0.1	0.1	-0.4	-0.3	-0.0
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.1	0.0	-0.0	-0.3
Osteoarthritis (self-reported)	0.0	0.1	0.1	0.4	0.0	0.1
Financial situation satisfaction	0.0	0.0	0.1	-0.2	0.2	-0.0
Risk taking	0.0	0.1	0.2	-0.4	-0.1	-0.1

Hub : Genes

ANXA2

Models

Trait associations