TWAS hub - ATRNL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0355	0.0229	0.0440	0.014	0.011	0.007	0.015	0.005	0.0052	0.0120	0.042	0.0037	0.061
2	TCGA	Bladder Urothelial Carcinoma	0.0420	0.0270	0.0083	-0.001	0.019	-0.001	NA	0.003	0.3900	0.0082	0.400	NA	0.160

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Relative age voice broke	9.7	14.8	28.2	5.3	-1.1
Risk taking	7.1	10.4	15.0	2.4	-3.9
Age when periods started (menarche)	6.1	14.5	19.9	4.5	-3.0
High blood pressure (mother)	5.4	7.5	12.9	-1.5	3.6
Mouth/teeth dental problems: Loose teeth	4.9	5.8	10.7	-3.3	-1.0
Average weekly red wine intake	4.9	7.3	14.1	3.8	-0.6
Bipolar Disorder (2018)	4.3	6.8	12.9	3.6	-0.8
Number of children fathered	4.3	4.8	8.9	3.0	-0.8
Alcohol usually taken with meals	4.1	6.6	7.6	2.8	-2.4
Number of full sisters	4.0	4.9	9.6	0.5	-3.1
Relative age of first facial hair	3.9	8.0	11.6	3.4	-2.1
Number of full brothers	3.9	5.0	8.9	3.0	-1.0
Osteoarthritis (self-reported)	3.8	5.0	9.9	-0.2	3.1
Noisy workplace	3.6	4.5	7.0	1.4	2.6
Chest pain or discomfort	3.5	5.0	8.4	1.3	-2.9
Qualifications: nursing, teaching	3.3	5.2	6.1	2.1	-2.5
Commuting to job workplace: Cycle	3.2	3.8	5.5	1.5	-2.3
Financial difficulties in last 2 years	3.1	4.2	7.2	-2.7	-1.1
Ever had bowel cancer screening	3.1	3.6	6.7	2.6	-0.8
Illnesses of mother	3.0	3.7	7.3	0.4	-2.7
Age started oral contraceptive pill	3.0	3.8	7.2	-0.6	2.7
Back pain experienced in last month	2.8	4.0	6.6	-2.6	1.2
Bipolar Disorder (2011)	2.6	2.5	3.9	2.0	-1.1
Chronic bronchitis/emphysema (mother)	2.6	3.0	5.8	2.4	-0.5
Worry (Nagel 2018)	2.5	5.4	10.4	3.2	-0.5
Medication: Atenolol	2.5	3.1	5.5	-2.3	-0.9
Handedness (chirality/laterality): Left-handed	2.5	3.0	3.4	1.6	-1.8
Mother’s age at death	2.5	3.2	5.6	2.4	-0.9
Pack years adult smoking proportion	2.4	3.6	3.7	-1.9	1.9
Irritability	2.4	4.1	4.5	-1.9	2.1
Angina (self-reported)	2.3	3.0	5.9	2.4	-0.1
Diastolic blood pressure, automated reading	2.3	7.1	10.8	-1.8	3.3
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	4.5	0.9	2.1
Angina	2.1	2.8	5.6	2.4	-0.1
Number of live births	2.1	2.9	3.3	1.8	-1.6
Pulse wave reflection index	2.1	2.7	5.2	-2.3	-0.4
Suffer from ‘nerves’	2.1	3.4	5.2	2.3	-1.2
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.6	3.3	1.8	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	4.4	-0.3	-2.1
Major Depression (MDD)	2.0	2.4	3.0	1.7	-1.3
Systolic blood pressure, automated reading	2.0	5.7	10.3	-1.1	3.2
Diabetes (self-reported)	2.0	3.1	5.8	2.4	-0.6
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	3.6	1.2	-1.9
Severe depression (siblings)	1.9	2.2	4.2	2.0	-0.3
Alcohol drinker status: Never	1.9	2.3	4.5	-0.3	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	2.7	-1.6	-1.3
Osteoporosis (self-reported)	1.8	2.2	4.4	0.3	-2.1
Guilty feelings	1.8	2.7	3.9	1.2	-2.0
Pack years of smoking	1.8	2.7	3.0	-1.7	1.5
Systolic Blood Pressure	1.7	8.3	10.3	-2.5	3.2
Supplements: Glucosamine	1.7	2.2	2.6	1.3	-1.6
Medication: Gliclazide	1.7	1.9	3.6	-0.4	1.9
Respiratory disease	1.6	3.5	4.6	2.1	-1.6
Hearing difficulty/problems: Yes	1.6	2.5	4.0	1.0	-2.0
Breastfed as a baby	1.6	2.0	3.9	-0.4	2.0
Gout (self-reported)	1.6	2.1	2.2	1.5	-1.4
Eye problems/disorders: Cataract	1.6	1.8	3.6	1.9	0.3
Ever had prostate specific antigen (PSA) test	1.6	1.8	2.9	0.9	1.7
Mean Putamen Volume	1.5	1.7	3.2	-1.8	0.3
Ulcerative Colitis	1.5	2.2	4.3	-0.1	2.1
Mouth/teeth dental problems	1.5	2.3	3.6	-1.0	1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	3.5	1.9	0.3
Family relationship satisfaction	1.5	1.8	3.4	-0.5	1.8
Diabetes diagnosed by doctor	1.5	2.4	4.1	2.0	-0.9
Tinnitus: Yes, now most or all of the time	1.5	1.7	2.7	-1.6	0.9
Number of operations (self-reported)	1.5	2.3	4.0	2.0	-0.7
Heart disease (siblings)	1.5	1.8	3.0	0.8	-1.7
Crohns Disease (2017)	1.4	3.0	4.8	2.2	1.1
Crohns Disease (2012)	1.4	2.3	4.1	2.0	0.7
Had other major operations	1.4	1.7	2.1	1.2	-1.4
Hair/balding pattern: Pattern 3	1.4	2.1	3.1	1.1	1.8
Prospective memory result	1.4	1.8	3.4	-0.4	-1.8
Asthma (self-reported)	1.4	2.7	4.5	2.1	-1.0
Bipolar Disorder or Schizophrenia	1.3	3.0	4.2	2.1	-1.4
Frequency of depressed mood in last 2 weeks	1.3	1.9	2.3	-1.2	1.5
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	3.3	1.8	-0.8
Shortness of breath walking on level ground	1.3	1.5	2.7	0.6	1.6
Eye problems/disorders: None of the above	1.3	1.6	2.0	-1.0	1.4
Migraine (self-reported)	1.3	1.6	3.1	0.3	-1.8
Medication: Allopurinol	1.3	1.8	2.6	1.0	-1.6
Friendships satisfaction	1.3	1.6	2.5	-0.8	1.6
Alzheimer’s Disease (in father)	1.2	1.3	2.6	0.3	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	3.9	2.0	0.2
Asthma	1.2	2.5	4.2	2.0	-0.9
Lung cancer (father)	1.2	1.4	2.7	-1.7	-0.3
Tense / ‘highly strung’	1.2	1.9	2.0	1.4	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	3.3	1.8	-0.6
Heart disease (mother)	1.2	1.4	2.8	1.7	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.5	1.5	-1.2	-1.2
Breast cancer (self-reported)	1.2	1.5	2.9	0.1	-1.7
Hearing aid user	1.2	1.3	2.2	-0.6	-1.5
Irritable Bowel Disease (IBD)	1.1	2.7	2.7	1.7	1.6
Hand grip strength (left)	1.1	3.0	4.0	1.4	-2.0
Townsend deprivation index at recruitment	1.1	1.5	3.0	-1.7	0.1
Number of incorrect matches in round	1.1	1.8	1.8	1.4	-1.3
Nervous feelings	1.1	2.0	3.9	2.0	0.3
Knee pain experienced in last month	1.1	1.7	2.8	-0.8	1.7
HbA1C	1.0	1.2	2.2	-1.5	0.3
Waist Hip Ratio (WHR)	1.0	4.4	8.4	-0.7	2.9
Sitting height	1.0	7.3	9.3	2.3	-3.0
Depression (self-reported)	1.0	1.2	1.3	1.1	1.1
Emphysema/chronic bronchitis	1.0	1.1	1.2	-1.0	-1.1
Schizophrenia (2014)	0.9	2.0	2.9	1.1	-1.7
Hand grip strength (right)	0.9	2.4	3.5	1.2	-1.9
Maternal smoking around birth	0.9	1.3	2.3	-0.6	-1.5
Medication: Levothyroxine sodium	0.9	1.6	3.1	-0.3	-1.8
Medication: Simvastatin	0.9	1.3	2.4	0.4	-1.6
Blood clot in the leg (DVT)	0.9	1.1	2.2	0.1	-1.5
Comparative body size at age 10	0.9	2.5	4.8	-0.4	2.2
Had major operations	0.9	1.1	2.1	0.1	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	2.1	1.5	-1.3
Medication: Bendroflumethiazide	0.9	1.4	2.4	-1.5	-0.6
Alcohol drinker status: Previous	0.9	1.0	1.2	1.1	-1.0
Alzheimer’s Disease (in mother)	0.8	1.0	1.9	-1.4	0.2
Qualifications: CSEs or equivalent	0.8	1.0	1.4	-1.2	-0.8
Allergy	0.8	1.9	3.0	-1.7	0.8
Pain all over the body in last month	0.8	0.8	1.2	0.6	-1.1
Fluid intelligence score	0.8	1.6	2.8	-1.7	0.6
Illnesses of siblings	0.8	1.1	1.5	-0.8	1.2
Headache pain in last month	0.8	1.3	2.6	-0.1	-1.6
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	2.4	0.9	-1.5
Exposure to tobacco smoke outside home	0.8	1.1	1.1	-1.1	-1.0
Pulse wave peak to peak time	0.8	0.9	1.6	0.5	-1.3
Mood swings	0.8	1.5	1.9	-1.4	1.0
Illnesses of father: High blood pressure	0.8	1.0	2.0	-1.4	0.0
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.1	0.1	-1.5
Average weekly fortified wine intake	0.7	0.9	1.7	1.3	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	2.3	1.1	-1.5
Hair/balding pattern: Pattern 4	0.7	1.7	2.5	-1.0	-1.6
Health satisfaction	0.7	0.9	1.0	0.9	1.0
Leg pain on walking	0.7	0.9	1.8	1.4	-0.0
Supplements: Vitamin C	0.7	0.8	1.2	-1.1	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.9	1.7	0.2
Supplements: Calcium	0.7	0.8	1.2	-1.1	0.6
Schizophrenia vs Biploar Disorder	0.6	0.8	1.5	-1.2	-0.4
LDL Cholesterol	0.6	0.9	1.5	-1.2	-0.6
Medication for hormone replacement therapy	0.6	0.7	1.4	0.1	1.2
Vitamin and mineral supplements	0.6	0.8	1.6	0.2	1.3
Heart attack	0.6	0.8	1.7	-0.1	-1.3
Pulse rate	0.6	1.0	1.1	1.0	1.0
Pulse wave Arterial Stiffness index	0.6	0.7	1.2	-0.5	1.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.5	0.1	-1.2
Pulse rate, automated reading	0.6	1.9	3.0	-0.8	1.7
Illnesses of father: Heart disease	0.6	0.9	1.2	-0.7	1.1
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.4	1.2	-0.8
Medication: Atorvastatin	0.6	0.8	1.0	0.7	1.0
Average weekly beer plus cider intake	0.6	0.8	1.2	-1.1	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.6	-0.0	-1.3
Alzheimer’s Disease (including proxy)	0.5	0.7	1.1	-0.5	1.0
Ulcerative Colitis (UC)	0.5	1.0	1.7	0.6	1.3
Primary Biliary Cirrhosis	0.5	0.7	1.4	-1.2	0.1
Allergy or Eczema	0.5	1.4	2.8	1.7	0.2
Cardiovascular Disease	0.5	1.7	2.5	-1.0	1.6
Medication: Co-codamol	0.5	0.6	1.1	1.1	0.1
Diabetes (father)	0.5	0.6	0.9	-0.6	0.9
Fed-up feelings	0.5	1.0	1.3	-1.1	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	1.3	1.0	-1.1
Multivitamins +/- minerals	0.5	0.6	1.1	0.1	-1.1
Stomach or abdominal pain in last month	0.5	0.7	1.3	-1.1	-0.1
Waist circumference	0.5	1.8	3.2	0.7	1.8
Forced vital capacity (FVC)	0.5	2.1	2.8	1.7	-1.1
Father’s age at death	0.5	0.6	0.8	0.9	0.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	2.1	1.0	-1.5
Happiness	0.5	0.7	1.1	-0.4	1.1
Mouth/teeth dental problems: Dentures	0.5	0.9	1.8	1.4	0.0
Standing height	0.5	5.0	6.6	1.8	-2.6
Birth weight of first child	0.5	1.0	1.6	1.3	0.6
Medication: Paracetamol	0.5	0.8	1.3	1.1	0.6
Medication: Seretide 50 evohaler	0.5	0.5	0.9	-0.4	0.9
Alcohol intake frequency.	0.5	1.2	2.3	-1.5	-0.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.1	1.1	0.0
Commuting to job workplace: Walk	0.5	0.6	1.1	0.1	1.1
Medication for cholesterol	0.5	0.8	1.3	0.5	-1.1
Medication: Paracetamol	0.5	0.8	1.5	1.2	0.3
Fractured/broken bones in last 5 years	0.5	0.7	1.3	-0.1	-1.1
Unable to work because of sickness or disability	0.5	0.6	1.2	0.0	1.1
Neuroticism (Nagel 2018)	0.4	0.9	1.7	1.3	0.0
Age at First Birth	0.4	0.6	0.6	-0.8	-0.7
Hypothyroidism (self reported)	0.4	0.8	1.1	1.0	-0.7
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.3	1.1	0.6
Lung FVC	0.4	2.0	4.0	2.0	0.0
Neuroticism	0.4	0.9	1.4	1.2	0.6
Number of treatments/medications taken	0.4	0.8	0.8	0.9	0.9
Average weekly spirits intake	0.4	0.5	0.8	-0.9	0.5
Ever had hysterectomy (womb removed)	0.4	0.5	0.9	1.0	-0.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.0	1.0	-0.2
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.8	1.3	0.1
Qualifications: A levels/AS levels or equivalent	0.4	0.8	0.9	0.9	1.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.1	0.2	-1.0
Medication: Lansoprazole	0.4	0.5	0.5	-0.7	-0.7
Length of working week for main job	0.4	0.5	0.9	-0.2	-0.9
Loud music exposure frequency	0.4	0.5	0.9	-1.0	0.2
Glaucoma (self-reported)	0.4	0.5	0.6	-0.7	-0.8
Worry too long after embarrassment	0.4	0.8	1.1	-0.6	1.1
Medication: Ibuprofen	0.4	0.5	0.8	0.5	-0.9
Medication: Omeprazole	0.4	0.5	0.6	0.6	0.8
Comparative height size at age 10	0.4	2.4	4.2	-2.1	0.8
Loneliness, isolation	0.4	0.5	1.0	0.3	-1.0
Medication: Aspirin	0.4	0.5	0.9	1.0	0.3
Smoking status: Current	0.4	0.6	0.8	-0.9	-0.7
Number of self-reported non-cancer illnesses	0.4	0.7	1.3	1.1	-0.1
Average weekly champagne plus white wine intake	0.4	0.5	0.7	0.6	-0.9
Financial situation satisfaction	0.4	0.5	0.8	0.9	0.4
Ever smoked	0.4	0.7	1.3	1.2	-0.3
Basal cell carcinoma (self-reported)	0.4	0.5	0.7	0.8	-0.5
Depression (Nagel 2018)	0.3	0.5	0.8	0.9	0.5
Schizophrenia (2018)	0.3	0.6	1.2	-0.3	-1.1
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	0.3	0.9
Lupus	0.3	0.5	0.9	-0.2	1.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	0.5	-0.8
Current tobacco smoking	0.3	0.5	1.1	-1.0	0.0
Serious illness, injury or assault to yourself	0.3	0.4	0.7	0.1	-0.9
High blood pressure	0.3	0.9	1.1	-1.1	0.8
Hair/balding pattern: Pattern 2	0.3	0.4	0.5	-0.7	-0.6
Arm fat percentage (right)	0.3	1.1	1.6	1.3	0.8
Alcohol intake versus 10 years previously	0.3	0.5	0.9	0.2	1.0
Worrier / anxious feelings	0.3	0.5	0.9	0.9	0.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.9	-0.3	-0.9
Forced vital capacity (FVC), Best measure	0.3	1.0	1.3	1.2	-0.8
Age at first live birth	0.3	0.6	0.8	-0.9	0.6
Neck or shoulder pain in last month	0.3	0.4	0.4	-0.6	0.6
Medication: Blood pressure	0.3	0.5	0.9	-0.9	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.4	-0.6	-0.7
Medication: Aspirin	0.3	0.4	0.8	0.9	-0.1
Arm fat percentage (left)	0.3	1.3	2.0	1.4	0.7
Illnesses of father: None of the above (group 1)	0.3	0.3	0.4	-0.6	-0.6
Ever taken oral contraceptive pill	0.3	0.3	0.4	0.5	0.7
Myopia	0.3	0.5	0.5	-0.7	0.7
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.0	-1.0	0.6
Ovarian Cancer	0.2	0.2	0.3	0.6	0.4
Prostate Cancer	0.2	0.2	0.4	0.7	-0.0
Coronary Artery Disease (CAD)	0.2	0.3	0.4	-0.6	-0.5
Fasting Glucose	0.2	0.2	0.4	-0.6	0.3
Neuroticism (2016)	0.2	0.2	0.3	0.5	0.5
Rheumatoid Arthritis	0.2	0.3	0.5	0.7	0.1
BMI	0.2	1.2	1.9	1.4	0.7
Smoking Status	0.2	0.6	1.1	0.2	-1.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	0.0	-0.7
Diabetes (mother)	0.2	0.2	0.5	-0.1	-0.7
Trunk fat percentage	0.2	0.9	1.6	1.3	-0.3
Taking other prescription medications	0.2	0.2	0.4	0.6	-0.3
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	0.5	0.5
Trunk fat mass	0.2	0.8	1.6	1.2	-0.2
Past tobacco smoking	0.2	0.3	0.6	-0.8	0.0
Hearing difficulty/problems with background noise	0.2	0.3	0.5	0.7	0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	-0.3	0.7
Medication: Ramipril	0.2	0.2	0.3	0.4	-0.5
Weight	0.2	0.8	1.4	1.2	-0.3
Impedance of arm (right)	0.2	0.8	0.9	1.0	-0.9
Hip circumference	0.2	0.7	1.2	1.1	0.3
Falls in the last year	0.2	0.2	0.3	-0.5	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	0.9	0.3	-1.0
Impedance of arm (left)	0.2	1.0	1.1	1.1	-1.0
Exposure to tobacco smoke at home	0.2	0.2	0.3	-0.0	-0.6
Peak expiratory flow (PEF)	0.2	0.6	0.7	0.7	-0.8
Medication: Amlodipine	0.2	0.3	0.5	-0.7	-0.3
High blood pressure (siblings)	0.2	0.2	0.3	0.5	-0.5
Body fat percentage	0.2	0.7	1.4	1.2	-0.1
Medication for pain relief, constipation, heartburn	0.2	0.4	0.4	-0.6	0.6
Overall health rating	0.2	0.5	0.6	0.8	-0.6
Age at last live birth	0.2	0.3	0.5	-0.7	0.4
Hypertension (Self-reported)	0.2	0.5	0.6	-0.8	0.6
Miserableness	0.2	0.3	0.6	-0.8	-0.0
Commuting to job workplace: Public transport	0.2	0.3	0.5	-0.7	0.2
Leg fat percentage (left)	0.2	0.6	1.1	1.0	0.4
Impedance of whole body	0.2	0.9	1.2	0.8	-1.1
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.6	-0.8	-0.1
HDL Cholesterol	0.1	0.1	0.2	0.1	-0.4
Triglycerides	0.1	0.1	0.2	0.2	0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.5	0.2
Heel T-Score	0.1	1.1	1.8	1.4	-0.5
Height	0.1	2.7	3.5	1.9	-1.4
Lung FEV1/FVC ratio	0.1	0.6	1.1	-1.0	-0.4
Hair Pigment	0.1	3.2	6.3	0.0	2.5
Tanning	0.1	1.4	2.6	-0.5	-1.6
Impedance of leg (right)	0.1	0.5	1.0	-0.3	-1.0
Leg fat-free mass (left)	0.1	0.5	0.9	0.9	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.1	-0.3	0.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	-0.3	0.3
Body mass index (BMI)	0.1	0.4	0.7	0.3	0.8
Impedance of leg (left)	0.1	0.3	0.6	-0.1	-0.7
Leg predicted mass (left)	0.1	0.5	0.8	0.9	-0.3
Qualifications: None of the above	0.1	0.1	0.2	-0.1	0.5
Neuroticism score	0.1	0.1	0.2	0.4	0.3
Medication: Cholesterol lowering	0.1	0.2	0.3	0.4	-0.5
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	0.1	-0.4
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.5	-0.1	0.7
Leg fat percentage (right)	0.1	0.5	0.9	0.9	0.3
Arm fat-free mass (right)	0.1	0.7	0.9	0.7	-1.0
Qualifications: College or University degree	0.1	0.4	0.7	0.9	-0.4
Mean time to correctly identify matches	0.1	0.2	0.3	0.4	0.5
Whole body fat mass	0.1	0.3	0.5	0.7	-0.1
Leg fat mass (right)	0.1	0.3	0.4	0.6	0.3
Arm predicted mass (right)	0.1	0.4	0.5	0.6	-0.7
Illnesses of siblings: Diabetes	0.1	0.1	0.1	0.4	-0.1
Smoking status: Previous	0.1	0.2	0.2	0.4	0.4
Leg fat-free mass (right)	0.1	0.5	0.9	0.9	-0.2
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.5	-0.1
Mineral and other dietary supplements	0.1	0.1	0.2	-0.4	-0.2
Whole body water mass	0.1	0.3	0.4	0.7	-0.5
Leg predicted mass (right)	0.1	0.5	1.0	1.0	-0.2
Arm fat mass (left)	0.1	0.3	0.5	0.7	0.3
Wears glasses or contact lenses	0.1	0.1	0.1	0.3	0.3
Medication: Blood pressure	0.1	0.2	0.2	-0.3	-0.5
High cholesterol (Self-reported)	0.1	0.3	0.5	-0.7	-0.2
Medication: Lisinopril	0.1	0.1	0.2	0.5	-0.1
Basal metabolic rate	0.1	0.4	0.6	0.8	-0.4
Arm fat-free mass (left)	0.1	0.4	0.7	0.4	-0.8
Ever depressed for a whole week	0.1	0.1	0.1	-0.1	-0.4
Vascular/heart problems diagnosed by doctor	0.1	0.1	0.3	0.5	0.0
Cholesterol lowering medication	0.1	0.1	0.2	0.3	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.4	0.2
Pain experienced in last month	0.1	0.2	0.4	0.7	-0.1
Leg fat mass (left)	0.1	0.3	0.5	0.7	0.4
Arm predicted mass (left)	0.1	0.5	0.6	0.5	-0.8
Depressed Affect (Nagel 2018)	0.0	0.1	0.1	-0.3	0.3
Reaction Time	0.0	0.0	0.1	-0.0	0.2
Breast Cancer	0.0	0.1	0.1	-0.3	0.4
Blood Eosinophil Count	0.0	0.1	0.1	0.1	0.3
Blood Platelet Count	0.0	0.5	1.0	1.0	0.1
Blood Red Count	0.0	0.3	0.5	0.7	-0.1
Blood White Count	0.0	0.2	0.4	0.6	0.3
Chronotype (morning person)	0.0	0.1	0.1	0.1	-0.3
Sensitivity / hurt feelings	0.0	0.1	0.1	0.2	-0.2
Ever used hormone-replacement therapy (HRT)	0.0	0.1	0.1	0.2	-0.3
Supplements: Zinc	0.0	0.0	0.1	-0.1	0.3
Medication: Metformin	0.0	0.1	0.1	0.1	0.3
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.1	0.2	-0.0
Had menopause	0.0	0.0	0.1	-0.3	-0.0
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	-0.3	-0.1
Trunk fat-free mass	0.0	0.1	0.2	0.4	-0.4
Time employed in main current job	0.0	0.1	0.1	-0.3	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	-0.0	-0.2
Arm fat mass (right)	0.0	0.2	0.3	0.5	0.3
Trunk predicted mass	0.0	0.1	0.2	0.4	-0.3
Birth weight	0.0	0.0	0.0	-0.1	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.1	0.0	-0.2
Wheeze or whistling in the chest in last year	0.0	0.0	0.1	-0.2	-0.0
Whole body fat-free mass	0.0	0.2	0.4	0.6	-0.3
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	-0.3	-0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	-0.1	0.2
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.1	0.3	-0.1

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ATRNL1

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