Hub : Genes

C11orf63

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.086	0.0320	2.9e-03	0.044	0.005	0.015	0.029	0.036	3.7e-06	0.063	5.5e-03	0.00016	2.8e-05
2	GTEx	Adipose Subcutaneous	0.119	0.0410	8.3e-04	0.113	NA	0.095	NA	0.098	1.6e-09	NA	3.3e-08	NA	2.3e-08
3	GTEx	Adipose Visceral Omentum	0.141	0.0540	7.4e-03	0.004	NA	-0.005	NA	0.015	2.0e-01	NA	8.1e-01	NA	5.1e-02
4	GTEx	Nerve Tibial	0.240	0.0481	3.4e-09	0.075	NA	0.225	NA	0.219	5.4e-06	NA	6.2e-16	NA	1.8e-15
5	GTEx	Testis	0.320	0.0780	4.5e-05	0.138	NA	0.052	NA	0.075	1.0e-06	NA	2.4e-03	NA	3.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.8	1.2	3.5	0.3	0.4	-0.4	1.9	-1.4
Bipolar Disorder or Schizophrenia	0.6	1.4	4.1	1.5	-2.0	-0.0	0.4	0.5
Depressed Affect (Nagel 2018)	0.6	1.2	1.9	1.4	1.0	-0.9	1.2	-0.8
Depression (Nagel 2018)	0.6	0.8	1.8	0.5	1.0	-1.4	0.1	-1.1
Intelligence (Savage-Jansen 2018)	0.4	1.2	4.3	-2.1	0.4	-0.8	-0.2	0.8
Neuroticism (Nagel 2018)	0.7	1.6	4.3	0.7	0.7	-1.6	2.1	-0.7
Schizophrenia (2018)	1.6	3.3	8.8	1.7	-3.0	0.5	-1.0	1.8
Schizophrenia vs Biploar Disorder	3.5	4.6	10.4	0.1	-3.2	-0.8	-2.3	2.6
Worry (Nagel 2018)	0.5	1.0	3.8	-0.3	0.3	-0.8	1.9	-0.6
Alzheimer’s Disease (in mother)	2.2	2.5	5.7	-1.5	1.8	0.2	1.2	-2.4
Alzheimer’s Disease (in father)	2.1	2.3	4.9	0.5	1.6	-1.7	0.9	-2.2
Alzheimer’s Disease (including proxy)	2.1	3.0	6.2	-1.1	2.0	-0.2	1.8	-2.5
Crohns Disease (2017)	0.1	0.3	0.7	-0.8	0.4	0.8	-0.1	-0.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	-0.3	-0.4	0.4	-0.0	-0.7
Ulcerative Colitis (UC)	0.2	0.3	0.8	0.5	-0.9	-0.5	0.1	-0.6
Major Depression (MDD)	1.6	2.0	4.0	0.8	0.9	0.8	2.0	-1.9
Reaction Time	0.9	1.6	3.1	1.2	1.4	1.0	1.8	-0.7
Verbal and Numeric Reasoning (VNR)	0.4	1.0	3.8	-1.9	1.0	0.1	-0.2	0.3
Breast Cancer	1.3	3.1	6.0	0.7	-1.6	2.1	-1.4	2.5
Ovarian Cancer	1.2	1.6	4.8	2.2	-0.7	0.9	-0.6	1.3
Prostate Cancer	0.3	0.5	1.7	-0.1	-0.8	-1.3	-0.4	0.1
Age at First Birth	0.4	0.5	0.6	0.7	0.5	-0.8	-0.7	0.8
Bipolar Disorder (2011)	0.8	0.8	1.7	0.7	0.2	-0.3	1.3	-1.2
Body Mass Index (BMI) (2010)	0.2	0.3	0.9	-0.9	0.4	-0.2	-0.7	-0.2
Coronary Artery Disease (CAD)	2.0	2.3	4.1	2.0	-1.9	1.4	-0.3	1.4
Crohns Disease (2012)	0.1	0.2	0.5	-0.2	-0.0	-0.7	-0.7	-0.0
Mean Putamen Volume	0.4	0.5	1.4	-0.4	1.2	-0.5	0.7	-0.2
Fasting Glucose	0.1	0.1	0.3	0.3	0.5	0.2	0.3	0.2
HbA1C	0.7	0.7	2.6	0.9	-0.3	0.2	-1.6	0.5
HDL Cholesterol	0.5	0.8	2.3	-0.6	0.0	1.5	1.1	-0.5
LDL Cholesterol	1.0	1.5	3.1	0.7	-0.7	1.7	-1.0	1.6
Lupus	0.4	0.5	1.9	-1.4	0.9	0.2	0.3	0.1
Neuroticism (2016)	0.4	0.6	2.3	1.5	-0.6	0.3	0.6	0.2
Primary Biliary Cirrhosis	0.5	0.7	2.5	-1.6	0.2	-0.1	0.5	-0.9
Rheumatoid Arthritis	0.4	0.5	1.8	-1.3	-0.0	0.5	-0.8	-0.0
Schizophrenia (2014)	1.6	3.6	8.7	1.9	-2.9	-0.3	-1.3	1.9
Triglycerides	0.5	0.8	1.7	0.2	-0.3	-1.0	-1.0	1.3
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.6	0.7	-0.5	-1.3	-1.1	1.1
Ulcerative Colitis	0.2	0.3	0.6	0.6	-0.5	-0.1	0.8	-0.7
Blood Eosinophil Count	0.3	2.5	5.2	-1.6	0.1	-0.8	-2.3	2.0
Blood Platelet Count	0.3	3.8	13.8	-1.5	-0.6	1.6	-3.7	-0.2
Blood Red Count	0.1	1.1	1.9	1.1	1.4	-0.7	0.7	-1.1
Blood White Count	0.1	1.0	4.2	-0.4	0.5	2.0	-0.0	-0.4
Heel T-Score	2.0	16.2	27.4	-0.2	5.2	-2.9	5.0	-4.5
BMI	0.2	1.3	4.9	-0.6	2.2	-0.4	-1.0	-0.6
Height	4.0	76.6	134.6	0.6	-11.2	1.2	-11.0	11.6
Waist Hip Ratio (WHR)	0.4	1.7	6.4	-0.2	-1.0	-0.5	-2.5	1.0
Systolic Blood Pressure	0.2	0.8	1.6	-0.8	0.4	1.1	0.6	-1.3
Smoking Status	0.8	2.0	2.5	1.4	1.2	-1.6	1.5	-1.2
Allergy or Eczema	0.5	1.2	4.1	-0.1	1.3	-0.2	0.5	-2.0
Cardiovascular Disease	0.0	0.1	0.3	-0.3	0.2	0.3	0.5	0.5
Hypothyroidism (self reported)	0.3	0.6	2.4	0.1	0.6	-1.5	-0.5	-0.5
Respiratory disease	0.6	1.3	2.5	-1.5	0.6	1.1	0.1	-1.6
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.5	0.7	-0.5	1.1	-1.0	1.2
Lung FEV1/FVC ratio	0.1	0.5	1.9	1.4	0.2	0.3	-0.5	0.6
Lung FVC	0.6	3.2	6.2	1.6	0.9	1.5	2.5	-2.1
Neuroticism	0.5	1.3	3.4	1.1	0.1	-1.3	1.8	-0.4
Chronotype (morning person)	0.5	1.3	5.9	-0.1	2.4	-0.4	-0.5	-0.0
Hair Pigment	0.0	1.1	2.8	-0.5	1.5	0.0	0.1	-1.7
Tanning	0.1	1.0	3.3	-1.0	-0.6	1.8	-0.0	0.3
Hand grip strength (left)	1.8	4.8	9.7	1.7	-2.7	0.5	-2.0	3.1
Number of treatments/medications taken	0.5	0.9	1.4	-0.1	-1.2	0.9	-0.9	1.2
Average weekly spirits intake	0.7	0.8	2.1	0.5	-0.3	-1.1	-0.8	1.5
Sensitivity / hurt feelings	0.8	1.4	3.1	0.5	1.3	-1.0	1.8	-1.1
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.1	-0.0	1.1	-1.1	0.4	-0.7
Hearing difficulty/problems: Yes	0.3	0.4	1.7	1.3	0.4	0.1	-0.1	-0.3
Relative age of first facial hair	14.6	30.1	60.6	0.6	-6.6	2.1	-7.8	6.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	0.9	0.5	0.8	0.0	-0.4
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.9	0.9	0.5	-1.3	0.2	-1.7
Ever had hysterectomy (womb removed)	0.4	0.4	1.4	-0.1	0.3	1.2	-0.7	-0.2
Systolic blood pressure, automated reading	0.6	1.6	3.5	0.2	1.9	0.0	1.0	-1.9
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.2	1.3	-0.8	-0.5	-1.5	1.4
Angina	0.3	0.5	0.9	0.7	0.3	-1.0	0.1	-0.9
Medication for hormone replacement therapy	0.2	0.2	0.6	0.1	-0.7	-0.2	0.3	-0.5
Vitamin and mineral supplements	0.4	0.5	1.2	1.1	-0.3	0.0	-0.8	0.8
Supplements: Zinc	0.0	0.0	0.1	-0.2	0.1	0.1	0.0	-0.2
Medication: Co-codamol	0.5	0.5	2.3	0.5	-0.3	1.5	-0.1	-0.1
Medication: Metformin	0.4	0.6	1.8	1.4	0.9	-0.0	0.4	0.5
Diabetes (father)	0.3	0.4	1.0	-0.2	-0.2	0.1	1.0	0.9
Diabetes (mother)	0.6	0.8	2.7	1.0	-0.4	1.6	-0.1	0.2
Severe depression (siblings)	0.6	0.6	1.2	0.5	1.1	-0.6	0.9	-0.7
Pack years adult smoking proportion	0.8	1.2	2.6	-0.6	-1.6	1.5	-0.4	0.7
Impedance of leg (right)	0.8	4.1	10.2	0.2	-3.2	0.6	-2.1	2.3
Leg fat-free mass (left)	0.7	3.8	9.8	-0.3	-1.6	-0.2	-3.1	2.5
Trunk fat percentage	1.6	6.5	22.6	0.3	-2.0	0.1	-4.8	2.4
Hand grip strength (right)	1.7	4.6	10.4	0.9	-2.9	0.1	-1.9	3.2
Townsend deprivation index at recruitment	0.6	0.8	1.4	-1.0	1.1	-0.6	-1.2	-0.1
Current tobacco smoking	0.7	1.2	4.8	0.1	0.2	-2.2	0.9	-0.6
Average weekly fortified wine intake	0.3	0.3	1.4	-1.2	0.2	0.4	-0.3	-0.2
Maternal smoking around birth	1.5	2.1	4.5	-0.6	-2.1	1.0	-1.8	1.2
Fed-up feelings	0.4	0.6	2.6	1.6	0.2	-0.1	-0.7	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.9	0.2	0.6	-1.0	-0.1	0.1
Relative age voice broke	13.6	20.7	39.8	-0.8	-5.2	1.1	-5.9	6.3
Taking other prescription medications	0.2	0.3	0.6	0.8	0.4	-0.6	-0.6	0.4
Age when periods started (menarche)	30.3	72.7	139.2	1.1	-10.8	2.1	-10.1	11.8
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	4.9	2.2	1.3	0.4	-0.1	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	4.2	0.4	2.0	-1.4	1.9	-2.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.6	0.3	-0.2	0.6	-0.6
Qualifications: CSEs or equivalent	1.0	1.4	4.6	1.5	-0.1	-2.1	0.4	0.2
Serious illness, injury or assault to yourself	2.6	3.2	5.9	-0.6	-2.2	-0.1	-2.4	2.2
High blood pressure	0.4	1.0	2.3	0.6	0.2	1.5	1.5	0.4
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.1	-0.9	0.6	-0.6	-0.1	-1.5
Multivitamins +/- minerals	0.4	0.5	1.2	-0.5	0.7	-0.6	1.1	-0.6
Stomach or abdominal pain in last month	1.5	1.8	4.7	-0.1	-1.6	1.3	-0.2	2.2
Supplements: Glucosamine	1.3	1.6	4.7	-0.9	1.1	0.5	2.2	-1.2
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	4.4	-0.8	1.5	0.9	2.1	-0.0
Medication: Atenolol	0.9	1.1	3.6	1.9	-1.4	-0.0	-0.2	0.1
Medication: Levothyroxine sodium	0.4	0.7	1.6	0.1	0.5	-1.3	0.2	-1.3
Sitting height	1.1	7.7	14.7	-0.8	-3.8	0.5	-3.2	3.5
Chronic bronchitis/emphysema (father)	0.4	0.5	1.6	0.7	0.4	-1.3	-0.5	0.2
High blood pressure (mother)	0.3	0.4	1.7	1.3	-0.5	-0.3	0.1	0.4
Body mass index (BMI)	0.2	0.8	2.5	0.6	1.6	-0.2	-1.0	-0.5
Impedance of leg (left)	1.2	5.9	13.2	1.2	-3.6	1.1	-2.3	2.8
Leg predicted mass (left)	0.7	3.6	9.4	-0.4	-1.6	-0.2	-3.1	2.5
Trunk fat mass	2.1	9.1	27.8	0.1	-2.6	0.3	-5.3	3.3
Waist circumference	0.6	2.3	9.0	-0.6	-0.6	0.3	-3.0	1.4
Number of incorrect matches in round	1.4	2.3	6.5	0.4	0.7	1.5	2.5	-1.5
Past tobacco smoking	0.7	1.3	2.0	-1.2	-1.4	1.0	-1.1	1.0
Alcohol usually taken with meals	0.6	0.9	3.0	-0.6	-0.7	-0.4	-1.7	0.7
Nervous feelings	0.3	0.6	2.5	0.7	0.0	-0.3	1.6	0.2
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	6.0	-0.1	2.5	-0.3	1.3	-1.4
Hearing difficulty/problems with background noise	0.1	0.2	0.8	0.9	0.0	-0.2	0.0	-0.1
Hair/balding pattern: Pattern 2	0.5	0.7	1.8	-1.3	0.9	0.8	0.4	-0.3
Had menopause	0.5	0.7	2.1	-0.2	0.6	-0.9	0.2	-1.5
Had other major operations	0.3	0.3	0.8	0.4	0.9	-0.6	-0.1	-0.5
Forced vital capacity (FVC)	1.0	3.9	6.1	-0.1	-2.4	1.2	-2.5	2.4
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	4.7	0.5	2.2	-1.0	2.1	-2.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.8	-0.9	0.3	-0.6	0.6	-0.3
Qualifications: None of the above	0.4	1.0	1.8	0.8	-0.6	1.0	-1.3	1.0
Financial difficulties in last 2 years	0.4	0.5	1.0	0.9	0.3	0.6	-1.0	0.6
Mouth/teeth dental problems	1.1	1.6	3.8	0.9	0.7	-2.0	1.5	-0.9
Heart attack	1.0	1.3	4.7	0.8	0.3	-2.2	0.9	-0.4
Allergy	0.5	1.1	2.6	1.2	-0.5	1.0	0.3	1.6
Pain all over the body in last month	4.5	4.9	10.8	-0.8	3.3	-1.7	1.6	-2.7
Diabetes (self-reported)	0.5	0.8	1.5	1.0	-0.4	1.2	-0.0	1.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.8	1.3	-0.0	-0.4	-0.8	-0.7
Medication: Ramipril	0.5	0.6	1.3	-0.2	-1.1	1.1	0.1	0.9
Medication: Simvastatin	0.3	0.5	1.0	0.5	-0.4	0.9	-0.5	1.0
Fluid intelligence score	0.5	1.0	2.7	-1.0	1.7	-0.2	1.0	-0.1
Illnesses of siblings	0.2	0.3	0.6	0.6	0.2	-0.6	-0.2	0.8
Neuroticism score	0.9	1.9	5.4	0.5	0.9	-1.5	2.3	-0.8
Weight	1.0	5.0	15.4	0.1	-1.6	0.1	-3.9	2.7
Impedance of arm (right)	1.6	7.4	16.8	-1.1	-4.1	0.6	-3.6	2.3
Arm fat percentage (right)	0.6	2.4	11.0	0.2	-0.6	0.2	-3.3	0.8
Trunk fat-free mass	0.6	3.7	9.2	0.0	-1.8	0.2	-2.4	3.0
Hip circumference	0.7	3.0	9.8	-0.4	-1.1	0.5	-3.1	2.0
Time employed in main current job	0.2	0.2	0.5	-0.1	-0.4	0.7	0.7	0.3
Alcohol intake versus 10 years previously	0.3	0.5	1.0	0.9	-0.6	-0.7	0.1	1.0
Father’s age at death	0.2	0.3	1.1	-0.1	0.5	0.1	-0.6	-1.1
Worrier / anxious feelings	2.4	4.5	9.7	-1.1	1.5	-2.4	3.1	-1.9
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	4.3	1.2	2.1	-0.9	0.9	-1.8
Falls in the last year	0.1	0.1	0.4	0.5	0.1	0.0	-0.3	0.6
Hair/balding pattern: Pattern 3	1.0	1.6	4.1	2.0	-0.1	-1.4	1.1	-0.8
Number of live births	1.2	1.7	3.8	1.9	-0.9	1.1	-1.3	0.9
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	6.2	0.4	-2.0	1.4	-2.5	2.2
Pulse rate	0.7	1.3	4.4	-0.7	-0.4	2.1	-1.1	0.3
Happiness	0.8	1.0	2.7	-0.2	-0.7	1.6	0.2	1.4
Noisy workplace	0.6	0.7	1.2	1.1	1.1	-0.1	-0.5	0.9
Qualifications: A levels/AS levels or equivalent	1.6	3.4	9.7	-3.1	1.8	0.9	0.1	-1.8
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.6	-0.3	-0.6	-0.7	-0.8	0.1
Mouth/teeth dental problems: Dentures	0.4	0.6	1.3	-1.1	1.2	0.2	-0.0	0.6
Asthma	0.2	0.4	0.9	-0.7	0.3	-0.1	-0.5	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	3.1	-1.8	0.2	0.6	0.2	0.9
Medication: Cholesterol lowering	0.7	1.1	3.0	0.4	-1.7	0.2	-0.9	1.3
Depression (self-reported)	0.4	0.5	1.2	0.1	-0.1	0.4	-1.1	1.0
Medication: Lansoprazole	1.3	1.4	3.0	-0.5	-1.7	-0.2	-1.6	1.1
Prospective memory result	0.5	0.6	1.6	1.3	0.1	-0.8	-0.8	0.7
Lung cancer (father)	0.3	0.4	0.8	0.0	0.9	0.7	0.1	-0.7
Illnesses of mother	1.3	1.6	3.8	-0.8	-1.2	-0.3	-1.4	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	5.6	1.0	-2.4	1.3	-1.9	2.0
Pulse wave Arterial Stiffness index	1.2	1.4	3.9	-2.0	-1.0	1.4	-0.5	-0.1
Impedance of arm (left)	1.6	7.6	15.3	-1.4	-3.9	0.8	-3.7	2.5
Arm fat mass (right)	0.8	3.1	12.2	0.3	-0.8	-0.3	-3.5	1.6
Trunk predicted mass	0.6	3.7	9.2	0.1	-1.8	0.1	-2.4	3.0
Standing height	2.9	28.4	48.3	-1.0	-6.8	0.5	-6.8	7.0
Length of working week for main job	1.0	1.2	2.9	-0.9	0.3	-1.7	0.2	-1.4
Exposure to tobacco smoke at home	0.9	1.0	1.9	0.5	-0.5	1.0	-1.4	1.3
Breastfed as a baby	1.1	1.4	6.8	-2.6	0.3	-0.4	0.1	-0.1
Tense / ‘highly strung’	0.1	0.2	0.6	-0.0	0.3	-0.8	0.6	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.2	-0.1	0.8	-0.4	1.1	-0.4
Hair/balding pattern: Pattern 4	0.3	0.7	2.3	0.6	-0.2	-0.3	1.5	0.7
Birth weight of first child	0.8	1.4	2.9	0.5	0.6	-1.7	-1.3	-1.3
Peak expiratory flow (PEF)	1.0	2.2	5.1	0.9	-0.9	0.7	-2.3	2.0
Pulse wave reflection index	0.7	0.8	2.7	-1.6	-0.8	0.7	0.5	-0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	0.1	0.0	0.5	-0.6	-0.0
Loud music exposure frequency	0.6	0.7	1.6	0.5	-0.8	0.7	-1.3	0.6
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	3.6	-1.3	1.8	-0.5	1.0	-1.9
Mouth/teeth dental problems: Bleeding gums	3.7	4.8	12.4	1.1	-2.2	1.7	-3.5	1.6
Blood clot in the leg (DVT)	0.4	0.5	1.0	-0.2	1.0	-0.8	0.8	-0.6
Medication: Paracetamol	0.4	0.7	1.9	-0.8	0.8	0.4	1.4	-0.2
Headache pain in last month	0.7	1.1	2.2	0.9	-0.8	1.4	-0.0	1.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.8	0.1	1.3	0.2	-0.0	-0.9
Glaucoma (self-reported)	0.3	0.4	0.8	-0.0	0.9	-0.5	0.5	0.6
Gout (self-reported)	0.3	0.4	1.0	-0.9	0.0	-0.3	-0.5	-1.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.9	-0.3	0.6	-1.4	-0.4	-0.6
Medication: Amlodipine	0.1	0.2	0.6	-0.4	0.2	0.8	0.2	-0.1
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.9	-0.1	-0.7	-1.4	-1.2	-0.2
Birth weight	1.0	2.2	9.4	-0.8	0.6	-3.1	-0.7	-0.2
Chronic bronchitis/emphysema (mother)	2.1	2.4	4.5	0.2	2.1	-0.5	2.1	-1.6
High blood pressure (siblings)	0.2	0.3	1.1	-0.3	0.4	0.2	1.1	-0.5
Forced vital capacity (FVC), Best measure	1.4	5.0	9.5	0.1	-3.1	2.0	-2.4	2.4
Body fat percentage	1.3	5.0	18.1	0.4	-1.6	0.4	-4.3	2.0
Leg fat percentage (right)	0.4	1.6	5.7	0.7	-0.4	0.7	-2.4	1.0
Arm fat-free mass (right)	0.6	3.1	8.2	0.5	-1.1	-0.0	-2.4	2.9
Exposure to tobacco smoke outside home	0.3	0.4	1.3	0.8	0.1	-0.0	-0.3	1.1
Comparative body size at age 10	3.7	10.3	22.6	-1.1	4.8	-2.2	2.0	-4.3
Number of full brothers	0.8	1.0	2.0	-0.1	-1.0	-1.1	-0.9	1.4
Worry too long after embarrassment	1.6	2.8	6.2	2.5	0.9	-2.1	1.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	3.6	-0.4	1.9	0.7	1.7	-1.2
Wheeze or whistling in the chest in last year	0.6	1.2	3.6	-0.1	-0.5	-1.3	-1.9	-0.3
Number of children fathered	0.4	0.4	1.4	0.3	0.6	-0.3	1.2	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.7	-0.9	-0.6	-0.8	0.9	1.3
Age at first live birth	1.5	2.7	5.4	-0.5	1.6	-1.2	2.3	-2.0
Pulse wave peak to peak time	1.0	1.2	3.2	1.8	0.5	-1.4	-0.1	0.8
Health satisfaction	0.8	1.0	2.0	-0.2	-0.6	1.0	-1.2	1.4
Shortness of breath walking on level ground	1.7	2.0	7.2	-0.8	-0.1	1.3	-2.7	0.7
Qualifications: College or University degree	0.5	1.7	3.3	-1.5	1.6	-0.0	0.2	-1.8
Eye problems/disorders: None of the above	0.9	1.0	3.9	-0.8	0.7	0.2	-0.1	-2.0
Mouth/teeth dental problems: Loose teeth	1.2	1.5	3.6	0.5	-1.0	-0.8	-1.9	1.3
Emphysema/chronic bronchitis	1.1	1.3	3.9	-2.0	0.1	1.2	-0.9	-0.3
Medication for pain relief, constipation, heartburn	0.5	0.9	1.6	1.2	-0.8	-0.8	-1.3	-0.4
Neck or shoulder pain in last month	0.3	0.4	1.8	-0.1	0.2	-0.3	1.3	-0.3
Medication: Blood pressure	0.2	0.4	1.2	0.0	-1.1	-0.4	0.7	0.1
Angina (self-reported)	0.4	0.5	1.1	0.6	0.5	-1.1	-0.0	-0.9
Migraine (self-reported)	1.6	2.0	4.1	0.8	1.1	-2.0	1.9	-0.6
Medication: Ibuprofen	1.0	1.2	3.5	-1.9	-0.2	1.0	-0.4	1.2
Medication: Allopurinol	0.2	0.3	0.6	-0.5	0.1	-0.2	-0.8	-0.7
Medication: Omeprazole	2.7	3.2	6.0	-1.4	2.4	-0.8	2.5	-1.4
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.4	-0.4	0.6	0.3	-0.5
Mean time to correctly identify matches	0.9	1.7	4.5	1.2	1.1	0.9	2.1	-0.9
Heart disease (mother)	0.2	0.2	0.6	-0.8	-0.3	-0.3	0.4	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.7	0.3	0.5	-0.7	-0.9	-0.2
Whole body fat mass	1.5	6.4	20.8	0.4	-1.9	0.1	-4.6	2.7
Leg fat mass (right)	1.1	4.1	12.9	0.1	-1.4	0.5	-3.6	2.3
Arm predicted mass (right)	0.6	2.9	6.9	0.5	-1.2	-0.1	-2.4	2.6
Pulse rate, automated reading	0.0	0.1	0.4	0.2	0.0	-0.4	-0.4	-0.6
Alcohol intake frequency.	0.6	1.3	3.8	0.8	-0.9	0.3	-1.9	1.1
Comparative height size at age 10	0.7	3.7	9.9	-1.4	2.1	-0.1	1.5	-3.1
Number of full sisters	0.5	0.6	0.9	-0.3	-0.7	0.7	-1.0	1.0
Suffer from ‘nerves’	0.2	0.3	0.7	0.8	-0.7	-0.2	0.5	-0.1
Overall health rating	0.3	0.7	1.4	-0.3	-0.9	-0.7	-1.2	0.9
Chest pain or discomfort	1.2	1.8	6.0	-2.5	-0.7	-0.1	-1.4	0.5
Had major operations	0.2	0.2	0.6	0.1	-0.8	-0.2	0.5	0.2
Age at last live birth	0.8	1.2	2.5	1.2	1.1	-0.2	0.7	-1.6
Family relationship satisfaction	0.3	0.4	1.3	0.2	-0.6	0.4	0.3	1.2
Leg pain on walking	0.2	0.3	0.8	-0.1	0.9	-0.1	-0.6	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.7	1.9	-0.9	-0.2	-0.3	1.1
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	-0.7	0.3	-0.1	0.3	0.3
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.8	-0.6	0.7	0.9	2.0	-0.1
Medication: Aspirin	0.3	0.4	1.0	0.3	1.0	-0.4	0.5	-0.6
Supplements: Vitamin C	0.2	0.3	0.5	-0.5	-0.7	0.3	-0.6	-0.3
Knee pain experienced in last month	0.6	0.9	2.6	-0.2	1.6	0.6	0.7	-1.1
Hypertension (Self-reported)	0.3	0.7	1.5	0.8	-0.3	1.2	1.0	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.1	-0.9	-0.0	1.1	0.8	-0.1
Illnesses of father: Heart disease	0.2	0.2	0.5	-0.7	-0.2	-0.1	0.6	0.4
Illnesses of siblings: Diabetes	0.5	0.6	1.4	-0.8	-0.2	0.7	-1.2	0.5
Smoking status: Previous	0.4	0.6	1.4	0.5	1.2	-0.0	0.6	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	4.2	8.8	18.0	-1.1	-3.7	0.6	-3.3	4.2
Whole body fat-free mass	0.7	3.8	8.3	0.1	-1.7	0.1	-2.7	2.9
Leg fat-free mass (right)	0.6	3.4	8.6	-0.1	-1.6	-0.1	-2.9	2.4
Arm fat percentage (left)	0.8	3.1	13.4	-0.1	-0.7	0.5	-3.7	1.2
Average weekly red wine intake	0.2	0.3	0.6	0.6	0.1	-0.8	-0.2	-0.6
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	-0.4	-0.5	-0.5	-0.4	-0.7
Mood swings	1.6	3.0	7.2	0.7	2.4	-0.4	2.7	-1.2
Loneliness, isolation	0.2	0.2	0.9	0.3	-0.0	0.3	-1.0	-0.1
Long-standing illness, disability or infirmity	0.5	0.7	3.0	0.4	-0.3	1.7	-0.1	-0.4
Ever had bowel cancer screening	1.4	1.7	2.9	0.6	1.7	-0.8	1.5	-1.5
Diabetes diagnosed by doctor	0.8	1.3	2.7	1.5	-0.2	1.6	-0.1	1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.2	1.5	-0.9	-1.4	-0.9	0.9
Friendships satisfaction	1.1	1.4	4.6	-1.1	-1.1	-0.1	-0.0	2.1
Qualifications: nursing, teaching	0.7	1.1	2.7	-1.1	0.7	0.9	0.6	-1.6
Commuting to job workplace: Walk	0.5	0.5	1.9	1.4	0.6	-0.2	0.4	0.3
Eye problems/disorders: Cataract	0.1	0.2	0.5	-0.3	-0.3	0.3	-0.2	0.7
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.0	-0.5	-0.5	1.0	-0.2	0.3
Medication for cholesterol	0.8	1.2	1.5	0.8	-1.0	-1.2	-1.2	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	0.8	0.7	0.9	-0.8	0.8	0.3
Back pain experienced in last month	0.5	0.7	1.8	0.5	-0.5	1.3	-1.0	0.2
Mineral and other dietary supplements	0.6	0.9	2.8	-1.0	-0.6	0.3	-1.7	0.3
Breast cancer (self-reported)	0.8	1.0	3.7	-1.9	0.9	0.4	0.3	-0.1
Asthma (self-reported)	0.1	0.3	0.5	-0.7	0.2	-0.1	-0.7	-0.7
Osteoporosis (self-reported)	0.4	0.5	1.3	1.1	-0.9	0.7	-0.3	-0.2
Osteoarthritis (self-reported)	0.9	1.1	3.4	-0.8	1.1	0.7	0.3	-1.9
Medication: Aspirin	0.1	0.1	0.4	0.4	0.6	-0.3	0.1	0.0
Medication: Gliclazide	0.9	1.0	3.4	1.9	0.4	-1.1	0.3	0.1
Illnesses of father: None of the above (group 1)	0.5	0.6	1.8	-0.0	0.3	1.3	-0.2	-1.0
Smoking status: Current	1.1	1.7	5.7	0.3	0.5	-2.4	1.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.2	1.8	-0.6	1.1	0.0	0.0
Whole body water mass	0.6	3.4	7.7	0.1	-1.6	0.1	-2.6	2.8
Leg predicted mass (right)	0.6	3.5	8.7	-0.1	-1.7	-0.1	-3.0	2.4
Arm fat mass (left)	0.9	3.6	13.5	0.3	-0.9	-0.2	-3.7	1.9
Number of self-reported non-cancer illnesses	0.3	0.6	1.6	0.8	-0.8	0.1	-0.1	1.3
Average weekly champagne plus white wine intake	0.3	0.4	2.0	-0.3	-0.2	1.4	0.3	0.1
Miserableness	0.6	1.1	2.2	1.2	0.6	-1.2	1.5	-0.6
Guilty feelings	1.5	2.3	8.1	0.5	1.2	-0.7	2.8	-1.2
Wears glasses or contact lenses	0.3	0.4	1.4	-1.2	-0.3	-0.3	0.1	-0.5
Ever taken oral contraceptive pill	0.4	0.4	1.1	1.0	-0.3	-0.7	0.3	0.5
Hearing aid user	0.5	0.6	1.9	1.4	-0.5	0.7	-0.6	0.2
Mother’s age at death	1.0	1.2	2.8	-1.1	0.6	0.6	1.1	-1.7
Financial situation satisfaction	2.1	2.6	7.8	-1.0	-1.4	0.8	-1.2	2.8
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	0.8	-0.2	-0.0	0.7	-0.8
Commuting to job workplace: Public transport	0.3	0.3	1.2	0.1	-0.3	0.3	-1.1	-0.6
Eye problems/disorders: Glaucoma	0.4	0.5	1.4	0.3	0.8	-0.3	0.3	1.2
Medication: Blood pressure	0.3	0.6	0.9	-0.4	1.0	0.9	0.3	-0.9
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	0.1	0.5	-0.9	0.6	-0.2
Supplements: Fish oil (including cod liver oil)	1.2	1.6	4.3	0.6	0.3	-2.1	1.8	-0.3
High cholesterol (Self-reported)	0.0	0.1	0.1	-0.4	0.3	0.1	0.1	-0.0
Medication: Bendroflumethiazide	0.2	0.3	1.0	0.4	-0.0	1.0	-0.4	-0.0
Medication: Paracetamol	0.8	1.2	3.8	-2.0	0.7	0.9	0.9	0.2
Medication: Lisinopril	1.4	1.8	2.8	1.6	-1.2	1.4	-0.5	1.7
Medication: Atorvastatin	1.9	2.3	5.2	-0.4	1.7	-1.3	2.3	-1.3
Illnesses of father: High blood pressure	0.4	0.5	1.6	0.5	-0.6	0.2	-0.4	1.3
Alcohol drinker status: Never	0.5	0.5	1.5	-1.2	-0.4	0.8	-0.7	-0.1
Ever smoked	0.7	1.2	3.2	1.8	0.7	-0.2	1.1	-1.1
Basal metabolic rate	0.7	4.1	9.6	0.2	-1.7	-0.0	-3.1	2.9
Leg fat percentage (left)	0.6	2.2	6.6	1.3	-0.6	0.9	-2.6	1.2
Arm fat-free mass (left)	0.6	3.0	7.5	0.8	-1.3	-0.3	-2.2	2.7
Number of operations (self-reported)	0.8	1.1	2.1	1.1	1.1	-0.8	0.8	-1.4
Average weekly beer plus cider intake	0.5	0.7	1.6	1.3	0.2	-1.3	-0.7	-0.0
Irritability	0.3	0.5	1.3	-0.5	0.5	-1.1	0.8	0.4
Risk taking	1.7	2.4	5.3	-1.0	-0.4	2.3	-1.2	2.0
Ever had prostate specific antigen (PSA) test	0.8	0.9	3.5	-0.3	-0.9	1.9	-0.1	-0.5
Fractured/broken bones in last 5 years	0.4	0.6	1.7	1.3	-0.2	-0.4	-0.7	0.6
Age started oral contraceptive pill	0.8	1.0	2.5	-0.6	1.0	-1.6	0.7	-0.6
Diastolic blood pressure, automated reading	0.2	0.6	1.3	0.7	0.2	0.4	-1.1	-1.1
Ever depressed for a whole week	0.4	0.5	1.8	-0.2	0.6	0.3	-0.6	-1.4
Unable to work because of sickness or disability	1.0	1.3	2.7	1.1	1.6	-1.4	0.5	-0.6
Commuting to job workplace: Cycle	0.6	0.8	2.1	-0.1	-0.3	1.3	-0.0	1.4
Myopia	1.4	2.0	5.8	-0.4	0.4	-2.4	-1.4	-1.4
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.1	-0.7	0.0	-1.5	-1.2	-0.4
Cholesterol lowering medication	0.8	1.1	2.4	0.1	1.4	0.8	1.6	-0.8
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	3.8	-1.1	1.8	-1.2	2.0	-1.3
Pain experienced in last month	0.2	0.3	1.0	0.4	0.0	-0.4	0.4	-1.0
Supplements: Calcium	0.8	0.8	2.1	0.3	0.6	0.6	1.4	-1.1
Basal cell carcinoma (self-reported)	1.6	1.9	5.0	-0.5	2.2	0.5	1.4	-1.4
Heart attack/myocardial infarction (self-reported)	0.9	1.1	3.8	0.7	0.4	-1.9	1.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	-0.2	0.6	-0.8	0.7	-0.3
Heart disease (siblings)	0.7	0.9	2.2	-0.8	0.7	-0.3	1.0	-1.5
Alcohol drinker status: Previous	0.2	0.3	0.7	0.5	0.8	-0.4	-0.4	-0.3
Pack years of smoking	0.7	1.1	3.2	-0.7	-1.2	1.8	-0.3	0.4
Impedance of whole body	1.6	8.1	17.7	-0.3	-4.2	0.6	-3.7	2.9
Leg fat mass (left)	1.1	4.4	13.5	0.5	-1.4	0.6	-3.7	2.4
Arm predicted mass (left)	0.5	2.7	6.2	1.1	-1.1	-0.2	-2.2	2.5