Hub : Traits :

Diabetes (mother)

16 significantly associated models · 9 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 6 19840492 21930988 1 1 3.9e-07 4.7e-09 8.1e-05 55 CDKAL1
2 10 11515875 13569805 2 1 1.1e-09 4.4e-10 1.0e+00 100 CAMK1D
3 10 93730592 95128815 1 1 3.2e-08 1.6e-07 7.7e-01 100 EIF2S2P3
4 10 113511441 115622375 2 1 2.4e-20 9.7e-69 2.9e-53 23 TCF7L2
5 11 71769936 73198494 1 1 1.1e-07 2.9e-08 1.0e-03 65 STARD10
6 16 67423939 68988905 2 1 1.2e-08 2.4e-07 1.5e-01 92 PLA2G15

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 3.32 2 0 0.0 0.00 1.0e+00 CDKAL1 STARD10
Irritable Bowel Disease (IBD) 2.65 2 0 0.0 0.00 1.0e+00 EIF2S2P3 STARD10
Verbal and Numeric Reasoning (VNR) 1.85 2 0 0.0 0.00 1.0e+00 EIF2S2P3 PLA2G15
Breast Cancer 6.22 2 2 6.1 0.00 1.0e+00 CDKAL1 TCF7L2
Age at First Birth 2.18 1 0 0.0 0.00 1.0e+00 PLA2G15
Bipolar Disorder 3.00 1 0 0.0 0.00 1.0e+00 PLA2G15
Body Mass Index (BMI) (2010) 2.57 1 0 0.0 0.00 1.0e+00 TCF7L2
Crohns Disease (2012) 2.50 1 0 0.0 0.00 1.0e+00 CDKAL1
Fasting Glucose 7.07 3 0 0.0 0.00 1.0e+00 CAMK1D STARD10 TCF7L2
HDL Cholesterol 5.93 1 1 3.0 0.00 1.0e+00 PLA2G15
Type 2 Diabetes (T2D) 18.20 3 2 6.1 0.00 1.0e+00 EIF2S2P3 STARD10 TCF7L2
Blood Eosinophil Count 3.95 3 2 6.1 0.00 1.0e+00 EIF2S2P3 PLA2G15 STARD10
Blood Platelet Count 0.93 2 1 3.0 0.00 1.0e+00 CDKAL1 EIF2S2P3
Blood Red Count 0.47 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Heel T-Score 0.63 2 0 0.0 0.00 1.0e+00 STARD10 TCF7L2
BMI 1.83 2 1 3.0 0.00 1.0e+00 PLA2G15 TCF7L2
Height 0.27 2 0 0.0 0.00 1.0e+00 CDKAL1 TCF7L2
Waist Hip Ratio (WHR) 5.81 3 3 9.1 0.00 1.0e+00 CDKAL1 EIF2S2P3 TCF7L2
Systolic Blood Pressure 2.45 3 1 3.0 0.00 1.0e+00 CAMK1D CDKAL1 TCF7L2
Cardiovascular Disease 1.38 2 0 0.0 0.00 1.0e+00 CAMK1D CDKAL1
Respiratory disease 2.02 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Type 2 Diabetes (T2D) 45.69 5 5 15.2 -1.00 7.3e-05 CAMK1D CDKAL1 EIF2S2P3 STARD10 TCF7L2
Lung FEV1/FVC ratio 8.54 2 2 6.1 0.00 1.0e+00 CAMK1D STARD10
Lung FVC 2.97 3 2 6.1 0.00 1.0e+00 CAMK1D PLA2G15 STARD10
Neuroticism 1.52 1 0 0.0 0.00 1.0e+00 PLA2G15
Hair Pigment 0.53 1 1 3.0 0.00 1.0e+00 CDKAL1
Relative age of first facial hair 1.60 1 0 0.0 0.00 1.0e+00 CDKAL1
Systolic blood pressure, automated reading 2.44 1 1 3.0 0.00 1.0e+00 CAMK1D
Eye problems/disorders: Diabetes related eye disease 4.91 1 0 0.0 0.00 1.0e+00 TCF7L2
Medication: Metformin 27.72 5 3 9.1 1.00 2.1e-04 CAMK1D CDKAL1 EIF2S2P3 STARD10 TCF7L2
Diabetes (father) 26.06 3 3 9.1 0.00 1.0e+00 CDKAL1 EIF2S2P3 TCF7L2
Impedance of leg (right) 1.70 3 0 0.0 0.00 1.0e+00 CDKAL1 PLA2G15 TCF7L2
Leg fat-free mass (left) 1.26 3 0 0.0 0.00 1.0e+00 PLA2G15 STARD10 TCF7L2
Trunk fat percentage 1.10 1 0 0.0 0.00 1.0e+00 TCF7L2
Fed-up feelings 1.59 1 0 0.0 0.00 1.0e+00 PLA2G15
Frequency of unenthusiasm / disinterest in last 2 weeks 2.55 1 0 0.0 0.00 1.0e+00 PLA2G15
High blood pressure 1.58 2 0 0.0 0.00 1.0e+00 CAMK1D CDKAL1
Sitting height 0.47 1 0 0.0 0.00 1.0e+00 CDKAL1
Body mass index (BMI) 1.64 1 1 3.0 0.00 1.0e+00 TCF7L2
Impedance of leg (left) 1.67 1 1 3.0 0.00 1.0e+00 PLA2G15
Leg predicted mass (left) 1.24 3 0 0.0 0.00 1.0e+00 PLA2G15 STARD10 TCF7L2
Trunk fat mass 1.02 1 0 0.0 0.00 1.0e+00 TCF7L2
Waist circumference 1.35 1 0 0.0 0.00 1.0e+00 TCF7L2
Frequency of tenseness / restlessness in last 2 weeks 2.18 1 0 0.0 0.00 1.0e+00 PLA2G15
Forced vital capacity (FVC) 1.83 2 0 0.0 0.00 1.0e+00 CAMK1D PLA2G15
Heart attack 2.67 1 0 0.0 0.00 1.0e+00 PLA2G15
Diabetes (self-reported) 29.56 5 2 6.1 1.00 1.5e-05 CAMK1D CDKAL1 EIF2S2P3 STARD10 TCF7L2
Medication: Ramipril 2.79 1 0 0.0 0.00 1.0e+00 CDKAL1
Medication: Simvastatin 3.67 2 0 0.0 0.00 1.0e+00 CAMK1D TCF7L2
Fluid intelligence score 1.29 1 0 0.0 0.00 1.0e+00 PLA2G15
Neuroticism score 1.65 1 0 0.0 0.00 1.0e+00 PLA2G15
Weight 1.19 1 0 0.0 0.00 1.0e+00 TCF7L2
Impedance of arm (right) 1.63 2 0 0.0 0.00 1.0e+00 PLA2G15 TCF7L2
Arm fat percentage (right) 1.27 1 0 0.0 0.00 1.0e+00 TCF7L2
Trunk fat-free mass 1.21 2 0 0.0 0.00 1.0e+00 CDKAL1 PLA2G15
Hip circumference 2.85 1 1 3.0 0.00 1.0e+00 TCF7L2
Worrier / anxious feelings 1.45 1 0 0.0 0.00 1.0e+00 TCF7L2
Forced expiratory volume in 1-second (FEV1) 3.41 1 1 3.0 0.00 1.0e+00 CAMK1D
Mouth/teeth dental problems: Dentures 1.86 1 0 0.0 0.00 1.0e+00 STARD10
Asthma 2.10 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Medication: Cholesterol lowering 3.77 2 0 0.0 0.00 1.0e+00 CAMK1D TCF7L2
Forced expiratory volume in 1-second (FEV1), Best measure 3.53 1 1 3.0 0.00 1.0e+00 CAMK1D
Impedance of arm (left) 1.61 2 0 0.0 0.00 1.0e+00 PLA2G15 TCF7L2
Arm fat mass (right) 1.33 1 1 3.0 0.00 1.0e+00 TCF7L2
Trunk predicted mass 1.24 2 0 0.0 0.00 1.0e+00 CDKAL1 PLA2G15
Tense / 'highly strung' 1.36 1 0 0.0 0.00 1.0e+00 PLA2G15
Hair/balding pattern: Pattern 4 2.63 1 1 3.0 0.00 1.0e+00 CDKAL1
Peak expiratory flow (PEF) 2.82 1 1 3.0 0.00 1.0e+00 CAMK1D
Ever highly irritable/argumentative for 2 days 2.68 1 0 0.0 0.00 1.0e+00 PLA2G15
Medication: Paracetamol 2.27 1 0 0.0 0.00 1.0e+00 CDKAL1
Headache pain in last month 1.79 1 0 0.0 0.00 1.0e+00 STARD10
Medication for cholesterol, blood pressure or diabetes 3.26 1 0 0.0 0.00 1.0e+00 CAMK1D
Birth weight 5.14 3 1 3.0 0.00 1.0e+00 CDKAL1 EIF2S2P3 TCF7L2
Forced vital capacity (FVC), Best measure 1.85 2 0 0.0 0.00 1.0e+00 CAMK1D PLA2G15
Body fat percentage 1.53 2 0 0.0 0.00 1.0e+00 CDKAL1 TCF7L2
Leg fat percentage (right) 2.17 2 1 3.0 0.00 1.0e+00 CDKAL1 TCF7L2
Arm fat-free mass (right) 1.14 2 0 0.0 0.00 1.0e+00 PLA2G15 TCF7L2
Age at first live birth 2.13 1 0 0.0 0.00 1.0e+00 PLA2G15
Qualifications: College or University degree 1.10 1 0 0.0 0.00 1.0e+00 PLA2G15
Medication for pain relief, constipation, heartburn 2.03 1 0 0.0 0.00 1.0e+00 CDKAL1
Medication: Blood pressure 2.21 1 0 0.0 0.00 1.0e+00 CAMK1D
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.76 1 0 0.0 0.00 1.0e+00 TCF7L2
Whole body fat mass 1.34 1 0 0.0 0.00 1.0e+00 TCF7L2
Leg fat mass (right) 1.80 1 1 3.0 0.00 1.0e+00 TCF7L2
Arm predicted mass (right) 1.08 1 0 0.0 0.00 1.0e+00 PLA2G15
Pulse rate, automated reading 2.21 3 0 0.0 0.00 1.0e+00 EIF2S2P3 STARD10 TCF7L2
Comparative height size at age 10 0.52 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Age at last live birth 2.01 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Hypertension (Self-reported) 1.46 2 0 0.0 0.00 1.0e+00 CAMK1D CDKAL1
Illnesses of siblings: Diabetes 15.12 3 2 6.1 0.00 1.0e+00 CAMK1D EIF2S2P3 TCF7L2
Whole body fat-free mass 1.24 3 0 0.0 0.00 1.0e+00 CDKAL1 PLA2G15 TCF7L2
Leg fat-free mass (right) 1.24 4 0 0.0 -0.97 2.8e-02 CDKAL1 PLA2G15 STARD10 TCF7L2
Arm fat percentage (left) 1.36 1 0 0.0 0.00 1.0e+00 TCF7L2
Loneliness, isolation 1.96 1 0 0.0 0.00 1.0e+00 PLA2G15
Diabetes diagnosed by doctor 34.16 5 3 9.1 1.00 3.0e-05 CAMK1D CDKAL1 EIF2S2P3 STARD10 TCF7L2
Ever had stillbirth, spontaneous miscarriage or termination 1.80 1 0 0.0 0.00 1.0e+00 TCF7L2
Qualifications: nursing, teaching 2.13 1 0 0.0 0.00 1.0e+00 TCF7L2
Breast cancer (self-reported) 2.34 1 0 0.0 0.00 1.0e+00 TCF7L2
Asthma (self-reported) 2.06 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Medication: Aspirin 3.19 1 0 0.0 0.00 1.0e+00 TCF7L2
Medication: Gliclazide 14.68 3 1 3.0 0.00 1.0e+00 CAMK1D EIF2S2P3 TCF7L2
Illnesses of father: None of the above (group 1) 4.77 1 0 0.0 0.00 1.0e+00 CAMK1D
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.87 1 1 3.0 0.00 1.0e+00 CAMK1D
Whole body water mass 1.25 2 0 0.0 0.00 1.0e+00 CDKAL1 PLA2G15
Leg predicted mass (right) 1.22 3 0 0.0 0.00 1.0e+00 PLA2G15 STARD10 TCF7L2
Arm fat mass (left) 1.29 1 0 0.0 0.00 1.0e+00 TCF7L2
High cholesterol (Self-reported) 2.22 1 0 0.0 0.00 1.0e+00 TCF7L2
Medication: Atorvastatin 4.11 1 0 0.0 0.00 1.0e+00 TCF7L2
Basal metabolic rate 1.21 2 0 0.0 0.00 1.0e+00 PLA2G15 TCF7L2
Leg fat percentage (left) 2.06 1 1 3.0 0.00 1.0e+00 TCF7L2
Arm fat-free mass (left) 1.19 2 0 0.0 0.00 1.0e+00 PLA2G15 TCF7L2
Diastolic blood pressure, automated reading 1.18 1 0 0.0 0.00 1.0e+00 TCF7L2
Vascular/heart problems diagnosed by doctor 1.72 2 0 0.0 0.00 1.0e+00 CAMK1D CDKAL1
Cholesterol lowering medication 3.79 1 0 0.0 0.00 1.0e+00 TCF7L2
Heart attack/myocardial infarction (self-reported) 3.00 1 0 0.0 0.00 1.0e+00 PLA2G15
Pack years of smoking 1.33 1 0 0.0 0.00 1.0e+00 STARD10
Impedance of whole body 1.88 3 1 3.0 0.00 1.0e+00 CDKAL1 PLA2G15 TCF7L2
Leg fat mass (left) 1.79 1 1 3.0 0.00 1.0e+00 TCF7L2
Arm predicted mass (left) 1.16 2 0 0.0 0.00 1.0e+00 PLA2G15 TCF7L2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.27
GTEx Adipose Visceral Omentum 0 0.0000 1.30
GTEx Adrenal Gland 0 0.0000 1.27
GTEx Artery Aorta 1 0.0336 1.29
GTEx Artery Coronary 0 0.0000 1.21
GTEx Artery Tibial 0 0.0000 1.34
GTEx Brain Caudate basal ganglia 0 0.0000 1.26
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.37
GTEx Brain Cerebellum 0 0.0000 1.35
GTEx Brain Cortex 0 0.0000 1.30
GTEx Brain Frontal Cortex BA9 0 0.0000 1.28
GTEx Brain Hippocampus 0 0.0000 1.21
GTEx Brain Hypothalamus 0 0.0000 1.16
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.23
GTEx Brain Putamen basal ganglia 0 0.0000 1.28
GTEx Breast Mammary Tissue 0 0.0000 1.25
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.22
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.34
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.26
GTEx Cells Transformed fibroblasts 0 0.0000 1.30
GTEx Colon Sigmoid 0 0.0000 1.22
GTEx Colon Transverse 0 0.0000 1.33
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.25
GTEx Esophagus Mucosa 0 0.0000 1.34
GTEx Esophagus Muscularis 1 0.0309 1.29
GTEx Heart Atrial Appendage 0 0.0000 1.26
GTEx Heart Left Ventricle 0 0.0000 1.29
GTEx Liver 0 0.0000 1.26
GTEx Lung 2 0.0696 1.29
GTEx Muscle Skeletal 0 0.0000 1.31
GTEx Nerve Tibial 0 0.0000 1.26
GTEx Ovary 0 0.0000 1.37
GTEx Pancreas 0 0.0000 1.32
GTEx Pituitary 0 0.0000 1.27
GTEx Prostate 1 0.1198 1.27
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.33
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.33
GTEx Small Intestine Terminal Ileum 0 0.0000 1.28
GTEx Spleen 1 0.0709 1.36
GTEx Stomach 0 0.0000 1.27
GTEx Testis 0 0.0000 1.32
GTEx Thyroid 1 0.0250 1.35
GTEx Uterus 0 0.0000 1.33
GTEx Vagina 0 0.0000 1.33
GTEx Whole Blood 1 0.0502 1.30
METSIM Adipose 1 0.0217 1.28
NTR Blood 2 0.0833 1.33
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.32
YFS Blood 3 0.0650 1.26
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.31
TCGA Breast Tumor 0 0.0000 1.11
TCGA Breast Normal 1 0.0238 1.19
TCGA Ovarian Tumor 0 0.0000 1.23
TCGA Prostate Tumor 1 0.0289 1.28