Hub : Genes

PCMT1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0829	0.0310	3.3e-05	0.069	NA	0.028	NA	0.058	4.0e-06	NA	2.8e-03	NA	2.5e-05
2	GTEx	Esophagus Gastroesophageal Junction	0.0850	0.0420	8.3e-03	0.062	NA	0.003	NA	0.059	2.8e-03	NA	2.3e-01	NA	3.6e-03
3	GTEx	Esophagus Muscularis	0.0800	0.0340	5.7e-04	0.037	NA	0.008	NA	0.039	2.7e-03	NA	1.0e-01	NA	2.0e-03
4	GTEx	Heart Atrial Appendage	0.0880	0.0400	2.4e-03	0.055	NA	0.044	NA	0.018	1.8e-03	NA	4.6e-03	NA	5.0e-02
5	GTEx	Muscle Skeletal	0.1060	0.0407	2.2e-06	0.067	NA	0.052	NA	0.055	3.6e-07	NA	6.9e-06	NA	4.3e-06
6	GTEx	Skin Sun Exposed Lower leg	0.0650	0.0290	7.6e-04	0.016	NA	-0.001	NA	0.008	1.7e-02	NA	4.0e-01	NA	6.5e-02
7	GTEx	Testis	0.1290	0.0430	8.4e-06	0.137	NA	0.083	NA	0.112	1.2e-06	NA	1.5e-04	NA	1.2e-05
8	METSIM	Adipose	0.0506	0.0168	1.2e-08	0.059	0.047	0.046	0.047	0.057	3.4e-09	1.3e-07	1.6e-07	1.3e-07	5.9e-09
9	YFS	Blood	0.0144	0.0069	5.5e-04	0.013	0.006	0.013	0.007	0.015	3.3e-05	3.2e-03	3.5e-05	2.0e-03	5.9e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	1.0	1.6	4.1	-1.3	-1.3	-1.2	-1.2	1.3	-0.7	-1.1	1.0	2.0
Bipolar Disorder or Schizophrenia	1.5	3.7	4.7	-2.0	-2.0	-2.0	-1.9	1.9	-1.4	-1.9	2.0	2.2
Depressed Affect (Nagel 2018)	0.5	1.0	1.6	-0.9	-0.9	-1.0	-0.9	0.9	-1.3	-1.0	1.1	1.1
Depression (Nagel 2018)	0.1	0.1	0.2	-0.2	-0.4	-0.0	-0.0	0.2	-0.4	-0.2	0.4	0.4
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.2	0.2	0.3	0.1	-0.4	0.0	0.0	0.1	0.1	0.2
Neuroticism (Nagel 2018)	2.2	5.1	6.9	-2.1	-2.2	-2.2	-2.1	2.1	-2.2	-2.2	2.6	2.5
Schizophrenia (2018)	1.0	2.1	3.0	-1.5	-1.5	-1.6	-1.5	1.4	-1.2	-1.5	1.7	1.2
Schizophrenia vs Biploar Disorder	0.2	0.3	1.1	-0.2	-0.2	-0.4	-0.6	0.1	-1.0	-0.6	0.3	-0.6
Worry (Nagel 2018)	1.0	2.2	3.8	-1.3	-1.4	-1.5	-1.4	1.3	-1.1	-1.3	2.0	1.8
Alzheimer’s Disease (in mother)	1.6	1.9	2.5	1.4	1.5	1.4	1.6	-1.4	0.7	1.3	-1.6	-1.3
Alzheimer’s Disease (in father)	0.7	0.8	1.2	0.9	0.7	0.7	1.1	-0.9	0.8	0.8	-0.7	-1.1
Alzheimer’s Disease (including proxy)	1.9	2.8	3.8	1.7	1.6	1.6	2.0	-1.7	1.3	1.7	-1.8	-1.8
Crohns Disease (2017)	0.9	2.0	3.4	-1.2	-1.3	-1.3	-1.4	1.2	-1.7	-1.5	1.3	1.8
Irritable Bowel Disease (IBD)	0.3	0.6	1.1	-0.7	-0.9	-0.9	-0.9	0.6	-0.4	-0.7	0.8	1.1
Ulcerative Colitis (UC)	0.2	0.3	0.5	-0.5	-0.7	-0.7	-0.7	0.5	0.2	-0.4	0.6	0.6
Major Depression (MDD)	2.5	3.0	4.0	-1.7	-1.7	-2.0	-1.6	1.5	-1.6	-1.8	1.9	1.8
Reaction Time	1.1	2.2	5.5	-1.6	-1.7	-1.6	-0.7	1.4	-0.4	-1.2	1.5	2.3
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.2	-1.0	-0.8	-0.8	-1.5	1.1	-0.7	-1.0	0.9	1.1
Breast Cancer	0.4	0.9	3.0	1.0	1.0	0.8	0.7	-0.8	-0.4	0.5	-1.0	-1.7
Ovarian Cancer	0.3	0.4	0.8	-0.6	-0.6	-0.7	-0.7	0.5	-0.9	-0.7	0.4	0.6
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.8	2.7	3.4	-1.6	-1.6	-1.8	-1.7	1.7	-1.8	-1.9	1.6	0.9
Bipolar Disorder (2011)	0.1	0.1	0.2	0.4	0.2	0.5	0.1	-0.2	0.2	0.2	-0.0	0.4
Body Mass Index (BMI) (2010)	1.1	1.5	2.2	1.2	1.0	1.3	1.5	-1.2	1.4	1.4	-1.2	-0.6
Coronary Artery Disease (CAD)	0.5	0.5	1.4	-0.7	-0.7	-0.5	-0.8	0.7	-1.2	-0.9	0.5	0.0
Crohns Disease (2012)	0.5	0.7	1.9	-0.6	-0.7	-0.7	-1.0	0.5	-1.4	-0.9	0.7	0.8
Mean Putamen Volume	3.9	4.5	5.3	-2.3	-2.3	-2.2	-2.0	2.2	-1.9	-2.2	2.2	1.9
Fasting Glucose	0.7	0.9	1.6	1.0	0.9	0.8	0.6	-0.8	1.3	1.1	-1.2	-0.3
HbA1C	0.1	0.2	0.7	0.2	-0.0	-0.2	0.6	0.1	0.5	0.2	-0.1	0.8
HDL Cholesterol	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.6	0.1	-0.3	-0.3	0.4	0.4
LDL Cholesterol	0.8	1.2	1.7	1.1	1.1	1.2	1.2	-1.1	0.9	1.1	-1.3	-0.9
Lupus	0.4	0.6	0.9	0.7	0.7	0.9	0.6	-0.6	0.7	0.8	-0.9	-0.7
Neuroticism (2016)	0.6	0.8	1.5	-1.0	-1.0	-0.8	-0.4	1.1	-0.4	-0.9	0.9	1.2
Primary Biliary Cirrhosis	0.1	0.2	0.4	-0.3	-0.6	-0.3	0.5	0.5	0.5	-0.1	0.4	0.6
Rheumatoid Arthritis	1.1	1.5	2.6	1.3	1.4	1.3	0.8	-1.2	0.8	1.1	-1.4	-1.6
Schizophrenia (2014)	2.6	5.8	7.1	-2.6	-2.7	-2.6	-2.2	2.5	-2.0	-2.6	2.4	2.0
Triglycerides	0.0	0.0	0.1	-0.1	-0.1	-0.0	0.2	0.2	-0.3	-0.1	-0.2	-0.3
Type 2 Diabetes (T2D) (2012)	1.3	1.5	2.2	1.5	1.2	1.2	1.1	-1.3	0.8	1.3	-1.2	-1.4
Ulcerative Colitis	1.2	1.8	2.5	-1.3	-1.6	-1.5	-1.2	1.2	-0.8	-1.3	1.6	1.3
Blood Eosinophil Count	0.8	6.2	8.5	-2.5	-2.4	-2.7	-2.6	2.3	-2.2	-2.3	2.9	2.4
Blood Platelet Count	0.0	0.1	0.2	0.4	0.4	0.2	0.1	-0.4	-0.2	0.4	-0.3	0.1
Blood Red Count	1.5	14.0	17.3	4.0	3.9	4.2	3.2	-4.0	2.7	3.6	-3.9	-3.9
Blood White Count	0.1	0.7	2.4	-0.7	-0.8	-0.8	-0.5	0.6	0.1	-0.4	1.1	1.5
Heel T-Score	1.0	8.2	9.9	-3.0	-3.1	-2.9	-2.2	3.0	-2.3	-2.9	3.0	3.0
BMI	0.0	0.0	0.0	0.0	0.0	0.2	0.0	0.1	-0.1	-0.0	0.1	0.1
Height	0.0	0.1	0.2	-0.2	-0.3	-0.3	-0.4	0.3	-0.3	-0.2	0.2	0.1
Waist Hip Ratio (WHR)	0.8	3.5	4.8	2.2	2.1	1.9	1.5	-2.1	0.8	1.8	-1.9	-2.0
Systolic Blood Pressure	0.2	0.9	2.0	1.1	1.2	1.0	0.2	-0.9	-0.3	0.6	-1.2	-1.4
Smoking Status	0.3	0.6	1.8	-0.8	-0.7	-0.7	-0.8	0.7	-1.3	-0.8	0.5	0.2
Allergy or Eczema	3.4	8.9	10.2	-3.1	-3.2	-3.1	-2.5	3.0	-3.1	-3.2	3.0	2.6
Cardiovascular Disease	0.5	1.7	5.3	-1.0	-0.9	-1.0	-1.6	1.1	-2.3	-1.4	1.0	0.9
Hypothyroidism (self reported)	0.5	1.0	1.6	1.3	1.2	1.2	0.6	-1.2	0.2	0.8	-1.0	-1.1
Respiratory disease	1.0	2.1	3.5	-1.4	-1.5	-1.4	-1.2	1.3	-1.9	-1.5	1.4	1.4
Type 2 Diabetes (T2D) (2018)	0.8	1.5	2.6	1.4	1.3	1.3	0.8	-1.4	0.6	1.0	-1.3	-1.6
Lung FEV1/FVC ratio	0.3	1.3	2.4	-1.2	-1.3	-1.4	-0.9	1.2	-0.1	-0.9	1.1	1.5
Lung FVC	2.4	12.1	14.1	3.6	3.7	3.7	3.3	-3.4	2.8	3.4	-3.8	-3.4
Neuroticism	1.2	2.9	4.4	-1.6	-1.6	-1.7	-1.6	1.6	-1.5	-1.6	2.1	1.9
Chronotype (morning person)	2.5	5.8	6.8	-2.5	-2.6	-2.6	-2.3	2.5	-1.9	-2.4	2.5	2.4
Hair Pigment	0.0	1.2	1.6	-1.2	-1.1	-1.0	-0.6	1.3	-1.1	-1.3	0.9	1.1
Tanning	0.5	5.5	6.6	-2.6	-2.4	-2.4	-2.2	2.5	-2.2	-2.5	2.2	2.2
Hand grip strength (left)	7.6	20.0	23.0	4.6	4.7	4.5	4.2	-4.6	4.7	4.8	-4.3	-3.7
Number of treatments/medications taken	0.4	0.7	1.7	0.6	0.6	1.0	1.3	-0.6	0.3	0.6	-1.2	-0.6
Average weekly spirits intake	1.2	1.4	2.6	-1.1	-1.2	-1.4	-1.1	0.8	-1.6	-1.2	1.6	0.5
Sensitivity / hurt feelings	8.1	13.8	17.5	-3.5	-3.6	-3.5	-3.9	3.4	-4.2	-3.9	4.0	3.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.9	-0.6	-0.7	-0.5	-0.0	0.6	-0.5	-0.5	0.7	0.9
Hearing difficulty/problems: Yes	3.2	4.8	6.3	2.1	2.0	2.1	2.1	-2.1	2.5	2.4	-2.3	-2.1
Relative age of first facial hair	1.8	3.8	4.8	2.1	2.0	2.1	1.9	-2.0	1.3	1.9	-2.0	-2.2
Other serious medical condition/disability diagnosed by doctor	3.1	4.0	4.8	2.0	2.1	2.1	1.6	-2.1	2.2	2.1	-1.8	-2.0
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.1	0.8	0.9	0.8	1.3	-0.6	1.5	1.2	-0.8	-0.6
Ever had hysterectomy (womb removed)	0.6	0.7	1.1	1.1	1.0	0.9	0.7	-1.0	0.1	0.8	-0.6	-1.0
Systolic blood pressure, automated reading	0.9	2.6	4.6	1.8	1.8	1.9	1.0	-1.6	0.7	1.4	-1.8	-2.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.2	0.3	0.3	0.4	0.7	-0.4	1.1	0.5	-0.4	-0.3
Angina	1.6	2.1	2.6	1.6	1.5	1.6	1.4	-1.6	1.5	1.6	-1.5	-0.8
Medication for hormone replacement therapy	2.8	3.1	3.8	1.8	1.9	1.8	1.7	-1.7	1.8	1.9	-1.8	-1.4
Vitamin and mineral supplements	0.1	0.1	0.3	0.1	0.1	0.1	0.6	0.1	0.1	0.1	-0.5	0.1
Supplements: Zinc	1.6	1.8	2.3	-1.4	-1.5	-1.4	-1.1	1.5	-1.1	-1.4	1.1	1.3
Medication: Co-codamol	0.1	0.1	0.2	-0.3	-0.3	-0.2	0.1	0.4	0.0	-0.3	0.4	0.4
Medication: Metformin	0.0	0.1	0.5	-0.1	-0.1	-0.0	-0.0	0.0	-0.2	-0.1	0.1	-0.7
Diabetes (father)	0.1	0.1	0.1	0.3	0.3	0.3	-0.1	-0.4	-0.1	0.3	-0.3	-0.1
Diabetes (mother)	0.8	1.1	2.7	0.7	0.6	0.7	1.5	-0.7	0.8	0.7	-1.3	-1.6
Severe depression (siblings)	2.2	2.5	6.0	-1.3	-1.3	-1.2	-1.9	1.1	-2.4	-1.8	1.5	1.2
Pack years adult smoking proportion	3.4	5.3	6.3	2.4	2.4	2.5	2.3	-2.3	2.0	2.2	-2.3	-2.2
Impedance of leg (right)	1.2	6.0	7.9	-2.3	-2.4	-2.5	-2.5	2.4	-2.8	-2.5	2.5	2.3
Leg fat-free mass (left)	0.2	0.9	1.1	0.9	1.0	1.0	0.8	-1.1	1.1	1.0	-0.9	-0.8
Trunk fat percentage	0.4	1.4	3.1	-1.1	-1.1	-1.1	-0.9	1.1	-1.8	-1.3	1.5	0.7
Hand grip strength (right)	7.6	20.5	22.8	4.5	4.6	4.6	4.5	-4.5	4.8	4.8	-4.4	-4.0
Townsend deprivation index at recruitment	7.5	10.6	14.0	3.4	3.5	3.4	3.1	-3.5	2.3	3.1	-3.7	-3.1
Current tobacco smoking	0.3	0.5	0.7	0.8	0.8	0.8	0.4	-0.8	0.2	0.7	-0.7	-0.7
Average weekly fortified wine intake	0.1	0.1	0.6	0.1	0.0	0.1	0.5	0.0	0.8	0.3	-0.2	0.4
Maternal smoking around birth	1.6	2.3	5.6	-1.2	-1.3	-1.3	-1.7	1.4	-2.4	-1.7	1.4	1.0
Fed-up feelings	1.1	2.1	3.5	-1.4	-1.5	-1.4	-1.1	1.5	-1.9	-1.7	1.3	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	1.8	1.2	1.0	1.2	1.3	-1.1	1.0	1.1	-0.9	-0.5
Relative age voice broke	0.1	0.2	1.1	0.5	0.3	0.4	-0.2	-0.5	-0.4	0.1	0.1	-1.0
Taking other prescription medications	1.0	1.5	2.2	-1.2	-1.3	-1.1	-1.1	1.0	-1.5	-1.3	1.1	1.4
Age when periods started (menarche)	0.2	0.4	0.7	-0.6	-0.5	-0.6	-0.9	0.4	-0.7	-0.6	0.8	0.7
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.2	0.9	0.8	0.9	0.8	-0.8	1.1	0.9	-0.7	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.3	-0.1	-0.2	-0.0	0.3	0.1	0.5	0.0	-0.1	-0.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	0.6	0.7	0.7	0.7	0.5	-0.7	-0.0	0.6	-0.8	-0.4
Qualifications: CSEs or equivalent	0.4	0.5	2.2	0.2	0.3	0.3	-0.5	-0.3	-1.2	-0.3	-0.6	-1.5
Serious illness, injury or assault to yourself	1.4	1.7	3.9	1.4	1.5	1.5	0.6	-1.4	0.2	1.0	-1.2	-2.0
High blood pressure	0.3	0.8	2.1	-0.8	-0.8	-0.6	-0.9	0.8	-1.5	-1.1	0.8	0.7
Hayfever, allergic rhinitis or eczema	3.2	6.9	8.2	-2.8	-2.9	-2.8	-2.2	2.8	-2.5	-2.7	2.5	2.4
Multivitamins +/- minerals	0.4	0.5	1.3	-0.6	-0.6	-0.5	-1.1	0.5	-0.8	-0.7	0.6	0.4
Stomach or abdominal pain in last month	0.3	0.4	1.0	0.5	0.6	0.6	1.0	-0.5	0.2	0.5	-0.5	-0.6
Supplements: Glucosamine	1.0	1.3	1.8	1.1	1.1	1.2	1.0	-0.9	1.2	1.0	-1.3	-1.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	0.4	0.5	0.5	0.2	-0.4	-0.1	0.2	-0.3	-0.4
Medication: Atenolol	2.7	3.4	4.6	1.8	1.9	1.9	1.8	-1.7	1.7	1.8	-2.1	-1.7
Medication: Levothyroxine sodium	0.1	0.2	0.7	0.2	0.2	0.2	-0.4	-0.2	-0.5	-0.1	-0.2	-0.8
Sitting height	0.5	3.3	3.8	1.8	1.9	1.8	1.5	-1.9	1.8	1.8	-1.7	-1.8
Chronic bronchitis/emphysema (father)	0.6	0.7	1.5	0.9	0.9	1.0	0.3	-0.9	0.2	0.5	-0.8	-1.2
High blood pressure (mother)	0.1	0.1	0.6	-0.3	-0.4	-0.3	-0.2	0.4	-0.1	-0.3	0.3	0.7
Body mass index (BMI)	0.1	0.6	1.1	0.8	0.9	1.0	0.8	-0.9	0.5	0.7	-0.7	-0.7
Impedance of leg (left)	1.3	6.1	7.3	-2.3	-2.4	-2.5	-2.5	2.4	-2.7	-2.5	2.6	2.3
Leg predicted mass (left)	0.2	0.9	1.2	0.9	1.1	1.0	0.8	-1.1	1.1	1.0	-0.9	-0.8
Trunk fat mass	0.2	0.9	2.2	-0.9	-0.9	-0.8	-0.7	0.8	-1.5	-1.1	1.2	0.5
Waist circumference	0.1	0.4	0.7	0.8	0.8	0.8	0.5	-0.9	0.2	0.6	-0.4	-0.5
Number of incorrect matches in round	1.3	2.2	3.5	-1.6	-1.6	-1.5	-1.1	1.5	-1.6	-1.5	1.9	0.8
Past tobacco smoking	0.2	0.4	0.6	0.6	0.6	0.6	0.7	-0.5	0.8	0.6	-0.4	-0.5
Alcohol usually taken with meals	1.5	2.3	3.0	-1.5	-1.5	-1.6	-1.4	1.7	-1.2	-1.4	1.7	1.7
Nervous feelings	0.0	0.0	0.1	0.2	0.1	0.1	-0.1	-0.1	-0.2	-0.0	0.1	-0.1
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	2.9	1.4	1.3	1.5	1.7	-1.3	1.5	1.5	-1.1	-1.1
Hearing difficulty/problems with background noise	4.3	6.9	8.4	2.5	2.5	2.6	2.9	-2.5	2.5	2.8	-2.6	-2.7
Hair/balding pattern: Pattern 2	0.4	0.5	1.0	-0.8	-0.8	-0.8	-0.4	1.0	-0.3	-0.8	0.5	0.9
Had menopause	0.1	0.1	0.6	0.4	0.4	0.3	-0.1	-0.2	-0.3	0.2	0.1	-0.8
Had other major operations	1.1	1.3	1.9	1.3	1.2	1.2	0.7	-1.4	0.7	1.2	-1.3	-0.9
Forced vital capacity (FVC)	1.0	3.7	6.8	1.9	2.0	1.9	1.5	-1.9	1.4	1.7	-2.1	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.2	0.3	0.3	0.3	0.6	-0.4	1.1	0.5	-0.4	-0.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.6	0.1	0.2	0.2	0.8	-0.3	-0.2	0.0	-0.1	-0.5
Qualifications: None of the above	0.6	1.3	2.0	1.1	1.0	1.2	1.4	-1.2	1.3	1.2	-1.2	-0.4
Financial difficulties in last 2 years	0.5	0.6	1.1	0.9	1.0	0.8	0.7	-0.9	0.1	0.8	-0.6	-1.0
Mouth/teeth dental problems	1.9	2.9	3.8	-1.8	-1.8	-1.9	-1.5	1.9	-1.1	-1.6	1.7	1.9
Heart attack	2.2	2.8	4.5	1.8	1.5	1.7	2.1	-1.7	1.6	1.8	-1.5	-1.3
Allergy	1.5	3.5	5.2	1.9	1.9	1.9	1.7	-1.9	2.3	2.0	-1.6	-1.4
Pain all over the body in last month	0.6	0.6	1.0	0.7	0.8	0.9	0.6	-0.8	1.0	0.8	-0.9	-0.6
Diabetes (self-reported)	1.4	2.1	5.2	1.6	1.6	1.6	0.9	-1.4	0.8	1.3	-1.2	-2.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.0	-0.9	-0.8	-0.8	-0.6	1.0	-1.4	-1.0	0.5	0.5
Medication: Ramipril	0.0	0.0	0.1	0.2	0.2	0.1	0.2	-0.2	0.0	0.2	0.0	-0.3
Medication: Simvastatin	0.2	0.3	1.0	0.3	0.1	0.2	1.0	-0.2	0.1	0.2	-0.5	-1.0
Fluid intelligence score	0.2	0.5	2.2	-0.6	-0.4	-0.5	-0.8	0.6	0.1	-0.4	0.5	1.5
Illnesses of siblings	0.3	0.4	1.1	-0.6	-0.7	-0.8	0.1	0.7	0.1	-0.4	0.7	1.0
Neuroticism score	0.8	1.7	2.4	-1.3	-1.3	-1.3	-1.1	1.4	-1.0	-1.2	1.5	1.4
Weight	0.0	0.1	0.3	0.3	0.5	0.5	0.3	-0.5	0.2	0.3	-0.2	-0.3
Impedance of arm (right)	1.8	8.4	10.0	-2.9	-3.0	-3.1	-2.6	3.0	-2.9	-2.9	3.2	2.4
Arm fat percentage (right)	0.1	0.2	0.7	-0.3	-0.3	-0.2	-0.2	0.2	-0.8	-0.5	0.7	0.1
Trunk fat-free mass	0.2	0.9	1.4	1.0	1.2	1.0	0.6	-1.2	1.0	1.0	-0.9	-0.8
Hip circumference	0.3	1.1	1.9	-1.0	-1.0	-0.9	-0.9	0.9	-0.9	-1.0	1.4	1.3
Time employed in main current job	0.6	0.7	1.2	-0.8	-0.7	-0.8	-1.1	0.7	-0.8	-0.9	0.9	0.7
Alcohol intake versus 10 years previously	1.3	1.9	2.5	1.5	1.4	1.4	1.5	-1.6	0.7	1.2	-1.6	-1.4
Father’s age at death	0.2	0.2	0.6	0.6	0.7	0.6	-0.6	-0.7	-0.2	0.4	-0.1	0.1
Worrier / anxious feelings	1.4	2.6	4.1	-1.6	-1.6	-1.7	-1.1	1.7	-1.1	-1.5	2.0	2.0
Frequency of tiredness / lethargy in last 2 weeks	3.4	5.6	6.6	2.5	2.5	2.6	2.1	-2.5	2.4	2.6	-2.4	-1.3
Falls in the last year	0.3	0.4	0.7	0.7	0.7	0.7	0.6	-0.4	0.4	0.5	-0.8	-0.6
Hair/balding pattern: Pattern 3	2.4	3.6	5.0	-2.0	-2.0	-1.9	-2.2	1.9	-1.4	-1.9	2.0	1.5
Number of live births	14.2	20.1	26.4	4.7	4.5	4.8	3.9	-4.6	3.3	4.3	-4.8	-5.1
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	2.7	1.2	1.3	1.1	1.0	-1.2	1.3	1.2	-1.6	-1.6
Pulse rate	0.9	1.5	3.1	1.3	1.3	1.2	1.0	-1.3	0.5	1.0	-1.3	-1.8
Happiness	4.1	5.0	5.9	-2.3	-2.4	-2.4	-2.1	2.3	-1.5	-2.2	2.4	2.4
Noisy workplace	0.2	0.2	1.2	-0.1	-0.2	-0.2	-1.1	0.0	-0.5	-0.3	0.4	-0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	-0.6	-0.5	-0.5	-0.2	0.7	0.2	-0.4	0.3	0.5
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.3	1.2	1.3	1.5	1.2	-1.2	1.1	1.1	-1.1	-0.8
Mouth/teeth dental problems: Dentures	0.9	1.5	1.9	1.4	1.4	1.3	1.2	-1.3	0.4	1.1	-1.3	-1.4
Asthma	1.0	2.0	3.1	-1.2	-1.2	-1.2	-1.8	1.1	-1.6	-1.4	1.2	1.7
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.2	0.2	0.2	0.1	-0.1	0.1	0.0	-0.3	0.3
Medication: Cholesterol lowering	1.4	2.1	4.7	1.5	1.5	1.5	1.5	-1.4	0.2	1.2	-1.5	-2.2
Depression (self-reported)	2.8	3.4	5.0	-1.7	-1.6	-1.7	-2.2	1.8	-2.0	-1.8	1.7	1.8
Medication: Lansoprazole	1.3	1.5	3.6	1.3	1.2	1.3	0.8	-1.5	0.3	1.0	-1.2	-1.9
Prospective memory result	0.6	0.7	1.2	-1.0	-1.1	-0.8	-0.4	1.0	-1.0	-1.0	0.7	0.2
Lung cancer (father)	0.1	0.1	0.2	0.2	0.1	0.3	0.1	-0.2	-0.4	0.0	-0.4	-0.2
Illnesses of mother	0.6	0.7	1.6	0.6	0.9	0.7	0.8	-0.8	1.3	0.9	-0.7	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	3.5	1.5	1.6	1.4	1.4	-1.6	1.7	1.5	-1.8	-1.9
Pulse wave Arterial Stiffness index	0.1	0.1	0.7	0.2	0.3	0.2	-0.4	-0.1	-0.1	0.0	-0.4	-0.9
Impedance of arm (left)	2.5	11.5	13.2	-3.4	-3.5	-3.6	-2.9	3.5	-3.6	-3.5	3.6	2.7
Arm fat mass (right)	0.0	0.1	0.3	-0.2	-0.1	0.0	-0.1	0.0	-0.6	-0.3	0.4	0.0
Trunk predicted mass	0.2	1.0	1.5	1.0	1.2	1.1	0.6	-1.2	1.0	1.0	-1.0	-0.8
Standing height	0.2	1.9	2.4	-1.5	-1.4	-1.6	-1.5	1.3	-1.1	-1.4	1.6	1.1
Length of working week for main job	0.1	0.1	0.2	0.3	0.2	0.4	0.3	-0.3	0.5	0.4	-0.4	0.0
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.2	-0.2	-0.2	0.1	0.1	-0.5	-0.3	0.1	-0.2
Breastfed as a baby	6.3	7.8	9.5	2.9	2.9	3.0	2.8	-2.7	2.3	2.7	-3.1	-2.6
Tense / ‘highly strung’	0.5	0.9	2.7	-0.9	-1.0	-1.0	-0.3	0.9	0.1	-0.5	1.2	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	3.7	5.6	6.7	-2.4	-2.4	-2.3	-2.4	2.3	-2.2	-2.3	2.6	2.5
Hair/balding pattern: Pattern 4	0.9	2.3	3.0	-1.7	-1.7	-1.7	-1.0	1.7	-0.9	-1.5	1.5	1.6
Birth weight of first child	0.6	1.1	2.1	-1.1	-1.1	-1.0	-0.8	1.0	-1.4	-1.1	1.1	0.5
Peak expiratory flow (PEF)	3.7	8.6	9.7	3.1	3.1	3.0	2.4	-3.1	2.8	3.0	-3.1	-2.7
Pulse wave reflection index	0.0	0.0	0.1	-0.1	-0.0	0.0	-0.0	0.1	0.3	-0.0	-0.0	0.0
Ever highly irritable/argumentative for 2 days	0.4	0.4	0.7	0.5	0.5	0.6	0.8	-0.5	0.8	0.6	-0.8	-0.6
Loud music exposure frequency	2.2	2.4	3.2	-1.5	-1.6	-1.5	-1.8	1.6	-1.8	-1.7	1.6	1.0
Qualifications: O levels/GCSEs or equivalent	3.4	5.4	6.9	-2.3	-2.2	-2.3	-2.6	2.3	-2.3	-2.4	2.5	2.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.0	-0.6	-0.6	-0.4	-1.0	0.4	-0.8	-0.7	0.5	0.4
Blood clot in the leg (DVT)	0.0	0.0	0.1	0.1	0.2	0.2	-0.1	-0.1	-0.1	-0.0	0.3	-0.4
Medication: Paracetamol	2.4	3.9	5.6	2.0	2.0	1.8	2.1	-2.0	1.6	1.9	-2.4	-2.0
Headache pain in last month	0.2	0.4	0.6	0.8	0.7	0.6	0.5	-0.6	0.5	0.7	-0.7	-0.0
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	1.1	0.1	-0.0	-0.0	0.3	-0.1	1.1	0.4	-0.0	0.3
Glaucoma (self-reported)	2.9	3.4	4.5	1.9	1.8	2.0	2.0	-1.9	2.1	2.0	-1.7	-1.2
Gout (self-reported)	5.1	7.0	10.3	2.8	2.8	2.7	2.2	-2.7	2.2	2.7	-3.2	-2.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	0.7	0.8	0.8	0.8	0.3	-0.7	0.2	0.5	-0.8	-0.7
Medication: Amlodipine	0.2	0.2	0.4	0.5	0.5	0.5	0.5	-0.6	-0.4	0.1	-0.4	-0.6
Medication: Ventolin 100micrograms inhaler	1.2	1.6	2.1	-1.3	-1.3	-1.3	-1.1	1.1	-1.4	-1.3	1.1	1.3
Birth weight	1.7	3.7	6.5	2.0	1.9	1.9	1.7	-2.0	2.6	2.1	-1.9	-1.0
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.7	0.2	0.3	0.6	-0.1	-0.3	-0.9	-0.1	-0.9	-1.3
High blood pressure (siblings)	0.1	0.2	0.9	-0.0	0.2	0.3	-0.4	-0.0	-0.9	-0.3	-0.4	-0.7
Forced vital capacity (FVC), Best measure	1.0	3.8	7.2	1.9	2.0	1.9	1.6	-2.0	1.5	1.7	-2.0	-2.7
Body fat percentage	0.2	0.9	2.1	-0.8	-0.8	-0.7	-0.7	0.8	-1.5	-1.0	1.2	0.6
Leg fat percentage (right)	0.2	0.6	1.7	-0.6	-0.6	-0.5	-0.6	0.5	-1.3	-0.8	1.0	0.7
Arm fat-free mass (right)	0.4	2.3	3.0	1.5	1.7	1.6	1.2	-1.7	1.4	1.5	-1.5	-1.3
Exposure to tobacco smoke outside home	4.0	5.4	7.7	2.4	2.5	2.5	1.9	-2.3	1.8	2.2	-2.8	-2.3
Comparative body size at age 10	1.6	4.3	5.7	-2.4	-2.4	-2.2	-1.7	2.4	-1.4	-2.1	2.0	1.9
Number of full brothers	10.3	13.0	14.8	3.8	3.9	3.8	3.1	-3.7	3.0	3.6	-3.7	-3.9
Worry too long after embarrassment	0.1	0.2	0.4	-0.4	-0.3	-0.4	-0.6	0.6	-0.4	-0.4	0.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.2	1.0	0.8	0.8	0.7	-1.1	0.6	0.9	-0.4	-0.5
Wheeze or whistling in the chest in last year	1.8	3.2	4.7	2.0	2.1	2.2	1.4	-1.9	0.9	1.7	-1.9	-1.7
Number of children fathered	0.2	0.3	0.6	0.3	0.4	0.4	0.8	-0.3	0.7	0.4	-0.5	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	1.8	-1.2	-1.3	-1.4	-0.7	1.2	-0.3	-1.0	0.7	0.6
Age at first live birth	4.3	7.6	10.2	-2.8	-2.8	-3.0	-2.5	2.8	-2.3	-2.7	2.5	3.2
Pulse wave peak to peak time	0.2	0.2	1.0	-0.4	-0.5	-0.4	0.1	0.4	-0.1	-0.2	0.6	1.0
Health satisfaction	0.0	0.1	0.3	-0.2	-0.1	-0.1	-0.1	0.1	0.5	0.0	0.2	0.3
Shortness of breath walking on level ground	2.4	2.8	3.6	1.6	1.7	1.7	1.9	-1.7	1.6	1.9	-1.4	-1.6
Qualifications: College or University degree	0.1	0.3	1.2	0.4	0.4	0.4	0.3	-0.4	1.1	0.6	-0.6	-0.4
Eye problems/disorders: None of the above	0.8	1.0	3.2	-0.7	-0.6	-0.9	-1.4	0.7	-1.8	-1.0	0.8	0.2
Mouth/teeth dental problems: Loose teeth	5.8	6.9	9.7	2.7	2.7	2.8	2.2	-2.7	1.9	2.4	-2.8	-3.1
Emphysema/chronic bronchitis	4.0	4.5	5.6	2.2	2.4	2.3	2.0	-2.1	1.4	2.2	-2.3	-2.0
Medication for pain relief, constipation, heartburn	0.7	1.1	2.1	-1.0	-1.0	-0.9	-1.4	1.1	-0.9	-1.0	1.2	0.7
Neck or shoulder pain in last month	3.7	5.2	6.2	2.4	2.5	2.5	1.8	-2.5	2.1	2.5	-2.2	-1.9
Medication: Blood pressure	0.2	0.4	0.6	-0.7	-0.6	-0.6	-0.2	0.6	-0.8	-0.7	0.7	0.6
Angina (self-reported)	1.3	1.8	2.2	1.4	1.4	1.4	1.3	-1.5	1.4	1.4	-1.3	-0.7
Migraine (self-reported)	2.4	3.0	3.7	1.8	1.9	1.9	1.4	-1.5	1.7	1.9	-1.8	-1.7
Medication: Ibuprofen	0.1	0.1	0.5	-0.2	-0.3	-0.2	0.2	0.2	0.2	-0.2	0.0	0.7
Medication: Allopurinol	4.2	5.5	7.8	2.6	2.5	2.5	2.0	-2.4	2.0	2.5	-2.8	-1.7
Medication: Omeprazole	0.2	0.2	0.7	0.2	0.2	0.2	0.7	-0.5	0.4	0.4	-0.2	0.9
Medication: Seretide 50 evohaler	0.3	0.3	0.7	0.7	0.5	0.6	0.4	-0.8	0.1	0.6	-0.4	-0.8
Mean time to correctly identify matches	0.2	0.4	1.7	-0.5	-0.6	-0.6	-0.1	0.4	0.1	-0.3	0.5	1.3
Heart disease (mother)	1.0	1.2	2.2	-0.7	-0.9	-0.9	-1.0	0.9	-1.2	-0.9	1.5	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.3	3.9	4.5	2.1	2.1	2.1	1.8	-2.1	1.5	1.9	-2.1	-2.0
Whole body fat mass	0.1	0.4	1.2	-0.5	-0.5	-0.4	-0.4	0.4	-1.1	-0.7	0.8	0.2
Leg fat mass (right)	0.1	0.3	0.8	-0.5	-0.4	-0.3	-0.5	0.4	-0.9	-0.6	0.6	0.5
Arm predicted mass (right)	0.5	2.5	3.2	1.6	1.8	1.7	1.3	-1.8	1.5	1.6	-1.6	-1.3
Pulse rate, automated reading	0.9	3.0	3.9	1.7	1.7	1.7	2.0	-1.7	1.3	1.6	-1.9	-1.7
Alcohol intake frequency.	0.8	1.9	2.6	1.4	1.4	1.6	1.3	-1.4	1.4	1.3	-1.5	-1.1
Comparative height size at age 10	0.0	0.1	0.4	-0.1	0.1	-0.2	-0.6	0.1	-0.3	-0.2	0.2	-0.0
Number of full sisters	1.5	1.8	3.3	1.4	1.4	1.3	0.7	-1.5	0.8	1.2	-1.6	-1.8
Suffer from ‘nerves’	0.3	0.5	0.7	-0.7	-0.8	-0.7	-0.6	0.8	-0.4	-0.6	0.9	0.5
Overall health rating	2.2	4.7	5.5	2.3	2.3	2.3	2.1	-2.3	1.8	2.2	-2.0	-1.9
Chest pain or discomfort	6.2	9.0	11.7	3.4	3.3	3.3	2.7	-3.4	2.1	3.0	-2.7	-2.8
Had major operations	0.7	0.8	2.7	-0.8	-1.1	-1.0	0.0	0.4	0.0	-0.5	1.2	1.6
Age at last live birth	0.1	0.2	1.0	-0.2	-0.2	-0.3	-0.1	0.3	0.1	-0.2	0.2	1.0
Family relationship satisfaction	1.3	1.6	2.7	-1.3	-1.4	-1.4	-0.9	1.2	-1.0	-1.3	1.6	1.1
Leg pain on walking	3.6	4.5	6.2	2.1	2.0	2.2	2.5	-2.0	2.3	2.2	-2.1	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.8	-0.1	-0.2	-0.3	-0.1	0.2	-0.9	-0.3	-0.2	-0.6
Commuting to job workplace: Car/motor vehicle	2.5	2.9	7.3	-1.3	-1.4	-1.4	-2.1	1.4	-2.7	-1.9	1.6	0.6
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	-0.9	-1.0	-0.7	-0.3	1.0	-0.3	-0.7	0.3	0.3
Medication: Aspirin	0.8	1.0	1.9	0.9	1.0	0.9	1.4	-0.9	1.2	1.1	-0.8	-0.6
Supplements: Vitamin C	1.8	2.1	2.9	-1.4	-1.3	-1.4	-1.6	1.3	-1.7	-1.6	1.7	0.8
Knee pain experienced in last month	8.6	13.3	15.4	3.8	3.8	3.9	3.8	-3.7	3.1	3.6	-3.5	-3.6
Hypertension (Self-reported)	0.3	0.9	1.9	-0.9	-0.8	-0.7	-0.9	0.9	-1.4	-1.1	0.8	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	2.5	1.6	1.5	1.5	1.4	-1.6	1.4	1.6	-1.0	-0.8
Illnesses of father: Heart disease	0.1	0.2	0.4	-0.5	-0.5	-0.6	0.5	0.3	-0.2	-0.4	0.4	0.6
Illnesses of siblings: Diabetes	5.6	6.9	8.5	2.6	2.6	2.7	2.6	-2.5	2.4	2.6	-2.7	-2.9
Smoking status: Previous	0.6	0.9	1.3	-1.1	-1.1	-1.1	-0.7	1.0	-1.1	-1.0	0.6	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.0	1.0	1.0	0.8	0.9	-0.9	0.8	1.0	-1.4	-1.4
Whole body fat-free mass	0.2	1.4	1.8	1.2	1.4	1.2	0.8	-1.4	1.2	1.2	-1.1	-1.0
Leg fat-free mass (right)	0.2	1.3	1.7	1.1	1.2	1.2	1.0	-1.3	1.3	1.2	-1.0	-0.9
Arm fat percentage (left)	0.1	0.3	0.9	-0.5	-0.5	-0.3	-0.2	0.4	-1.0	-0.6	0.8	0.3
Average weekly red wine intake	0.2	0.2	0.5	-0.5	-0.5	-0.7	-0.5	0.6	0.1	-0.3	0.6	0.3
Handedness (chirality/laterality): Left-handed	1.2	1.5	3.4	-1.3	-1.1	-1.2	-1.0	1.1	-0.6	-1.2	1.4	1.8
Mood swings	0.3	0.5	1.9	-0.7	-0.8	-0.7	-0.0	0.7	-0.0	-0.5	0.7	1.4
Loneliness, isolation	1.1	1.5	2.0	1.3	1.3	1.1	1.4	-1.3	1.4	1.4	-0.8	-1.0
Long-standing illness, disability or infirmity	1.4	2.1	2.9	1.7	1.7	1.7	1.1	-1.7	1.0	1.4	-1.0	-1.5
Ever had bowel cancer screening	0.1	0.1	0.3	0.4	0.3	0.5	0.1	-0.3	0.3	0.3	-0.5	-0.3
Diabetes diagnosed by doctor	0.7	1.2	3.3	1.1	1.1	1.1	0.7	-1.0	0.7	0.9	-0.9	-1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.8	2.2	-1.5	-1.3	-1.2	-1.1	1.4	-1.3	-1.4	1.3	1.3
Friendships satisfaction	0.1	0.2	0.4	-0.4	-0.5	-0.5	-0.2	0.4	-0.3	-0.5	0.6	-0.1
Qualifications: nursing, teaching	1.8	2.7	3.2	-1.7	-1.6	-1.7	-1.5	1.8	-1.6	-1.7	1.6	1.6
Commuting to job workplace: Walk	0.6	0.7	1.8	0.7	0.7	0.7	1.0	-0.7	1.4	1.0	-0.6	-0.2
Eye problems/disorders: Cataract	0.2	0.2	0.5	0.4	0.4	0.5	0.7	-0.4	0.5	0.3	-0.3	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	1.9	1.2	1.1	1.4	1.2	-1.1	1.0	1.2	-1.1	-0.9
Medication for cholesterol	0.7	1.0	2.0	-0.9	-1.0	-1.1	-1.4	0.8	-1.1	-1.1	1.0	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.9	4.6	5.6	1.9	2.1	2.2	2.2	-2.1	2.2	2.1	-2.4	-2.1
Back pain experienced in last month	5.0	7.3	8.5	2.7	2.7	2.9	2.7	-2.7	2.9	2.9	-2.7	-2.1
Mineral and other dietary supplements	0.2	0.3	0.7	-0.5	-0.4	-0.5	-0.5	0.4	-0.5	-0.5	0.4	0.8
Breast cancer (self-reported)	0.1	0.1	0.3	-0.3	-0.3	-0.3	-0.5	0.2	0.0	-0.3	0.4	0.1
Asthma (self-reported)	1.0	2.0	2.9	-1.3	-1.3	-1.2	-1.7	1.2	-1.7	-1.4	1.2	1.7
Osteoporosis (self-reported)	0.4	0.5	2.1	-0.7	-0.6	-0.8	-0.2	0.6	0.8	-0.2	0.4	1.4
Osteoarthritis (self-reported)	0.5	0.6	1.0	0.9	0.8	1.0	0.9	-0.7	0.2	0.7	-1.0	-0.6
Medication: Aspirin	0.3	0.3	0.9	0.5	0.6	0.5	0.9	-0.6	0.6	0.6	-0.3	-0.4
Medication: Gliclazide	2.9	3.3	6.6	1.8	1.9	1.8	1.6	-1.7	0.7	1.5	-2.1	-2.6
Illnesses of father: None of the above (group 1)	0.1	0.1	0.6	-0.1	-0.1	-0.3	-0.7	0.2	-0.6	-0.3	0.3	-0.2
Smoking status: Current	0.2	0.3	0.5	0.6	0.7	0.7	0.2	-0.7	-0.1	0.5	-0.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	4.8	8.3	2.2	2.2	2.1	1.9	-2.2	1.7	2.0	-2.4	-2.9
Whole body water mass	0.4	2.1	2.7	1.4	1.6	1.5	1.1	-1.6	1.4	1.4	-1.4	-1.3
Leg predicted mass (right)	0.3	1.4	1.8	1.1	1.3	1.2	1.0	-1.3	1.4	1.2	-1.0	-1.0
Arm fat mass (left)	0.0	0.0	0.2	-0.1	-0.1	0.0	0.1	-0.0	-0.4	-0.2	0.3	-0.0
Number of self-reported non-cancer illnesses	1.3	2.2	2.9	1.5	1.6	1.7	1.5	-1.4	0.7	1.4	-1.7	-1.6
Average weekly champagne plus white wine intake	3.9	5.4	6.7	-2.3	-2.5	-2.5	-2.1	2.2	-2.6	-2.5	2.5	1.7
Miserableness	1.8	3.1	3.7	-1.7	-1.7	-1.7	-1.7	1.6	-1.9	-1.9	1.9	1.8
Guilty feelings	1.9	2.8	3.9	-1.6	-1.8	-1.8	-1.6	1.6	-1.0	-1.4	2.0	1.9
Wears glasses or contact lenses	0.9	1.0	2.1	-1.1	-1.3	-1.0	-0.6	1.0	-0.7	-0.9	0.9	1.4
Ever taken oral contraceptive pill	0.0	0.0	0.1	0.0	0.1	0.0	0.1	-0.1	-0.1	0.0	-0.3	-0.2
Hearing aid user	1.1	1.2	4.1	0.9	0.7	0.8	1.1	-0.8	2.0	1.3	-0.9	-0.6
Mother’s age at death	0.5	0.7	1.4	-0.7	-0.8	-0.8	-1.0	0.6	-0.6	-0.7	0.5	1.2
Financial situation satisfaction	0.2	0.3	0.5	-0.6	-0.5	-0.5	-0.7	0.6	-0.3	-0.5	0.5	0.3
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.8	0.9	0.9	0.9	0.3	-0.8	0.3	0.7	-0.7	-0.6
Commuting to job workplace: Public transport	0.7	0.8	2.4	0.7	0.9	0.6	0.9	-0.7	1.6	1.1	-0.7	0.0
Eye problems/disorders: Glaucoma	2.0	2.3	4.7	1.4	1.3	1.4	1.8	-1.6	2.2	1.7	-1.1	-0.8
Medication: Blood pressure	0.0	0.1	0.4	0.1	0.3	0.3	0.1	0.1	-0.1	0.1	-0.2	0.6
Pain type(s) experienced in last month: Hip pain	16.5	20.7	23.7	4.8	4.8	4.9	4.6	-4.6	4.3	4.8	-4.3	-3.7
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.4	0.4	0.2	0.4	0.6	-0.4	0.5	0.4	-0.4	-0.6
High cholesterol (Self-reported)	0.1	0.1	0.3	-0.3	-0.5	-0.3	0.5	0.3	-0.5	-0.3	0.2	0.1
Medication: Bendroflumethiazide	0.1	0.1	0.3	-0.1	-0.1	0.2	-0.2	0.4	-0.5	-0.2	0.3	0.5
Medication: Paracetamol	1.5	2.3	3.5	1.5	1.4	1.3	1.9	-1.3	1.4	1.5	-1.8	-1.5
Medication: Lisinopril	0.6	0.8	1.6	-1.1	-1.0	-0.9	-0.3	1.1	-0.3	-0.8	0.5	1.3
Medication: Atorvastatin	1.0	1.3	2.0	1.4	1.4	1.3	0.9	-1.3	-0.2	0.9	-0.8	-1.4
Illnesses of father: High blood pressure	0.9	1.1	4.1	-0.9	-0.7	-0.7	-1.1	1.0	-2.0	-1.2	0.5	0.4
Alcohol drinker status: Never	1.5	1.8	2.8	1.3	1.2	1.4	1.7	-1.1	1.1	1.3	-1.7	-1.0
Ever smoked	2.2	3.8	5.1	-2.0	-1.9	-1.9	-2.2	2.0	-2.0	-2.0	1.8	1.7
Basal metabolic rate	0.2	1.0	1.4	1.0	1.2	1.1	0.7	-1.2	1.0	1.0	-0.9	-0.8
Leg fat percentage (left)	0.2	0.6	1.4	-0.6	-0.6	-0.5	-0.6	0.5	-1.2	-0.8	1.1	0.7
Arm fat-free mass (left)	0.5	2.6	3.3	1.6	1.8	1.8	1.3	-1.8	1.6	1.6	-1.6	-1.4
Number of operations (self-reported)	0.4	0.6	1.1	0.9	0.8	0.8	0.7	-1.1	0.6	0.9	-0.7	-0.1
Average weekly beer plus cider intake	7.5	10.9	12.4	3.5	3.5	3.4	3.0	-3.5	2.9	3.4	-3.2	-3.2
Irritability	1.5	2.5	4.9	-1.7	-1.8	-1.5	-0.7	1.7	-1.0	-1.5	1.6	2.2
Risk taking	0.3	0.4	1.1	-0.4	-0.5	-0.6	-0.7	0.5	-1.1	-0.7	0.5	-0.3
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.1	-1.1	-1.1	-1.1	-1.4	1.1	-1.4	-1.2	1.1	0.5
Fractured/broken bones in last 5 years	0.9	1.2	1.5	1.2	1.2	1.0	0.7	-1.2	0.8	1.1	-1.2	-1.2
Age started oral contraceptive pill	0.4	0.5	2.0	0.5	0.5	0.5	1.0	-0.3	1.4	0.8	-0.0	0.0
Diastolic blood pressure, automated reading	0.2	0.6	2.3	-0.4	-0.4	-0.3	-1.1	0.7	-1.5	-0.8	0.3	-0.1
Ever depressed for a whole week	0.1	0.1	0.2	-0.4	-0.3	-0.4	0.1	0.3	-0.5	-0.3	0.3	0.1
Unable to work because of sickness or disability	2.0	2.6	3.0	1.7	1.6	1.7	1.6	-1.7	1.5	1.7	-1.7	-1.3
Commuting to job workplace: Cycle	3.5	4.2	4.9	2.2	2.2	2.2	2.0	-2.2	1.8	2.1	-1.8	-1.8
Myopia	0.5	0.7	1.0	-0.8	-0.8	-0.9	-1.0	0.7	-0.9	-0.9	0.3	0.9
Vascular/heart problems diagnosed by doctor	0.0	0.0	0.3	0.1	0.0	-0.0	-0.0	-0.1	0.5	0.2	0.0	-0.3
Cholesterol lowering medication	0.1	0.1	0.3	0.3	0.1	0.3	0.6	-0.3	0.2	0.2	-0.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	0.6	0.6	0.6	0.9	-0.9	0.5	0.6	-0.5	0.4
Pain experienced in last month	5.4	9.1	10.6	-3.2	-3.1	-3.2	-3.0	3.2	-2.5	-3.1	2.9	2.6
Supplements: Calcium	0.3	0.3	1.0	-0.6	-0.7	-0.7	-0.1	0.5	0.2	-0.3	0.6	1.0
Basal cell carcinoma (self-reported)	2.1	2.5	3.2	1.8	1.7	1.6	1.7	-1.8	1.2	1.7	-1.4	-0.9
Heart attack/myocardial infarction (self-reported)	2.6	3.3	5.3	1.9	1.7	1.8	2.3	-1.8	1.8	2.0	-1.7	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.4	-0.1	-0.0	-0.0	-0.3	0.1	-0.5	-0.3	0.6	-0.1
Heart disease (siblings)	0.8	1.0	1.3	-1.1	-1.1	-1.0	-0.9	0.9	-1.2	-1.1	0.8	0.7
Alcohol drinker status: Previous	0.4	0.4	1.0	-0.7	-0.5	-0.5	-1.0	0.7	-0.6	-0.7	0.5	0.1
Pack years of smoking	3.1	4.6	5.6	2.2	2.2	2.4	2.3	-2.2	1.8	2.1	-2.1	-2.0
Impedance of whole body	2.3	11.9	13.4	-3.4	-3.5	-3.7	-3.1	3.6	-3.6	-3.5	3.6	2.9
Leg fat mass (left)	0.1	0.3	0.8	-0.5	-0.4	-0.3	-0.5	0.3	-0.9	-0.6	0.7	0.5
Arm predicted mass (left)	0.8	3.8	4.9	2.0	2.2	2.1	1.6	-2.1	1.9	2.0	-1.9	-1.7