Hub : Traits :

Average weekly beer plus cider intake

101 significantly associated models · 17 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 49016056 50932324 12 1 2.4e-10 1.0e-09 4.3e-02 89 MST1R
2 4 99528449 100942337 1 1 3.9e-07 4.3e-08 2.2e-05 40 ADH1B
3 7 75059331 76363886 2 1 7.1e-09 9.2e-07 6.2e-01 99 MDH2
4 8 8165004 9669775 1 1 8.2e-08 1.2e-07 4.3e-02 85 ERI1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.6 1 0 0.0 0 1 MST1R
Irritable Bowel Disease (IBD) 3.9 1 1 3.0 0 1 MST1R
Ulcerative Colitis (UC) 5.4 1 1 3.0 0 1 MST1R
Verbal and Numeric Reasoning (VNR) 5.9 1 1 3.0 0 1 MST1R
Prostate Cancer 2.4 1 0 0.0 0 1 MST1R
Age at First Birth 8.4 1 1 3.0 0 1 MST1R
Crohns Disease (2012) 2.4 1 0 0.0 0 1 MST1R
Neuroticism 5.2 1 1 3.0 0 1 ERI1
Ulcerative Colitis 5.0 1 1 3.0 0 1 MST1R
Blood Eosinophil Count 1.5 2 0 0.0 0 1 ADH1B MST1R
Blood Platelet Count 0.8 1 1 3.0 0 1 MDH2
Blood White Count 1.3 1 1 3.0 0 1 MST1R
BMI 6.1 1 1 3.0 0 1 MST1R
Smoking Status 4.4 1 1 3.0 0 1 MST1R
Respiratory disease 2.2 1 0 0.0 0 1 MST1R
Lung FVC 1.3 1 0 0.0 0 1 MST1R
Neuroticism 2.4 1 0 0.0 0 1 MST1R
Chronotype (morning person) 3.5 1 0 0.0 0 1 MST1R
Number of treatments/medications taken 3.6 1 0 0.0 0 1 MST1R
Sensitivity / hurt feelings 4.2 1 1 3.0 0 1 ERI1
Frequency of depressed mood in last 2 weeks 7.0 1 0 0.0 0 1 ERI1
Relative age of first facial hair 3.2 1 0 0.0 0 1 MST1R
Medication: Co-codamol 4.4 1 0 0.0 0 1 MST1R
Impedance of leg (right) 6.1 3 2 6.1 0 1 ERI1 MDH2 MST1R
Leg fat-free mass (left) 3.4 2 1 3.0 0 1 ERI1 MST1R
Trunk fat percentage 1.6 1 0 0.0 0 1 MST1R
Maternal smoking around birth 4.7 1 0 0.0 0 1 MST1R
Fed-up feelings 6.2 2 0 0.0 0 1 ERI1 MST1R
Frequency of unenthusiasm / disinterest in last 2 weeks 5.9 1 0 0.0 0 1 ERI1
Taking other prescription medications 5.5 1 1 3.0 0 1 MST1R
Age when periods started (menarche) 4.3 1 1 3.0 0 1 MST1R
Heel bone mineral density (BMD) T-score, automated (left) 3.5 1 1 3.0 0 1 ERI1
Qualifications: CSEs or equivalent 4.3 1 0 0.0 0 1 MST1R
High blood pressure 2.4 1 0 0.0 0 1 ERI1
Sitting height 1.3 1 1 3.0 0 1 ERI1
Body mass index (BMI) 8.0 2 1 3.0 0 1 ERI1 MST1R
Impedance of leg (left) 6.3 3 2 6.1 0 1 ERI1 MDH2 MST1R
Leg predicted mass (left) 3.5 2 1 3.0 0 1 ERI1 MST1R
Trunk fat mass 2.9 1 1 3.0 0 1 MST1R
Waist circumference 3.3 1 1 3.0 0 1 MST1R
Past tobacco smoking 2.5 1 0 0.0 0 1 MST1R
Alcohol usually taken with meals 6.5 2 0 0.0 0 1 ERI1 MDH2
Nervous feelings 2.8 1 0 0.0 0 1 ERI1
Frequency of tenseness / restlessness in last 2 weeks 5.9 2 0 0.0 0 1 ERI1 MST1R
Forced vital capacity (FVC) 1.4 1 0 0.0 0 1 MST1R
Heel bone mineral density (BMD) T-score, automated (right) 2.8 1 0 0.0 0 1 ERI1
Ever unenthusiastic/disinterested for a whole week 5.8 1 0 0.0 0 1 MST1R
Qualifications: None of the above 7.8 1 1 3.0 0 1 MST1R
Fluid intelligence score 5.1 1 1 3.0 0 1 MST1R
Neuroticism score 7.4 2 1 3.0 0 1 ERI1 MST1R
Weight 4.5 2 1 3.0 0 1 ERI1 MST1R
Impedance of arm (right) 7.2 2 1 3.0 0 1 ERI1 MST1R
Arm fat percentage (right) 4.0 2 1 3.0 0 1 ERI1 MST1R
Trunk fat-free mass 2.5 1 1 3.0 0 1 MST1R
Hip circumference 3.4 2 1 3.0 0 1 ERI1 MST1R
Alcohol intake versus 10 years previously 4.7 1 0 0.0 0 1 MST1R
Worrier / anxious feelings 7.2 1 1 3.0 0 1 ERI1
Number of live births 3.1 1 0 0.0 0 1 MST1R
Forced expiratory volume in 1-second (FEV1) 2.1 1 0 0.0 0 1 MST1R
Qualifications: A levels/AS levels or equivalent 8.3 1 1 3.0 0 1 MST1R
Mouth/teeth dental problems: Dentures 3.6 1 0 0.0 0 1 MST1R
Forced expiratory volume in 1-second (FEV1), Best measure 2.5 1 0 0.0 0 1 ERI1
Impedance of arm (left) 7.1 2 1 3.0 0 1 ERI1 MST1R
Arm fat mass (right) 5.8 2 1 3.0 0 1 ERI1 MST1R
Trunk predicted mass 2.4 1 1 3.0 0 1 MST1R
Exposure to tobacco smoke at home 6.2 1 0 0.0 0 1 MST1R
Tense / 'highly strung' 5.1 1 1 3.0 0 1 ERI1
Peak expiratory flow (PEF) 4.2 1 1 3.0 0 1 ERI1
Ever highly irritable/argumentative for 2 days 5.0 1 0 0.0 0 1 MST1R
Qualifications: O levels/GCSEs or equivalent 2.5 1 0 0.0 0 1 MST1R
Medication: Paracetamol 2.9 1 0 0.0 0 1 MST1R
Hypothyroidism/myxoedema (self-reported) 2.4 1 0 0.0 0 1 ERI1
Chronic bronchitis/emphysema (mother) 4.3 1 0 0.0 0 1 MST1R
Forced vital capacity (FVC), Best measure 1.6 1 0 0.0 0 1 MST1R
Body fat percentage 2.6 1 1 3.0 0 1 MST1R
Leg fat percentage (right) 4.4 1 1 3.0 0 1 MST1R
Arm fat-free mass (right) 3.6 1 1 3.0 0 1 MST1R
Exposure to tobacco smoke outside home 5.3 1 0 0.0 0 1 MST1R
Comparative body size at age 10 5.2 2 1 3.0 0 1 ERI1 MST1R
Number of full brothers 4.0 1 0 0.0 0 1 MST1R
Worry too long after embarrassment 2.8 1 0 0.0 0 1 ERI1
Wheeze or whistling in the chest in last year 3.4 1 0 0.0 0 1 MST1R
Age at first live birth 7.0 1 1 3.0 0 1 MST1R
Qualifications: College or University degree 11.8 1 1 3.0 0 1 MST1R
Whole body fat mass 4.4 1 1 3.0 0 1 MST1R
Leg fat mass (right) 5.8 1 1 3.0 0 1 MST1R
Arm predicted mass (right) 3.8 2 1 3.0 0 1 ERI1 MST1R
Alcohol intake frequency. 9.4 1 1 3.0 0 1 ADH1B
Suffer from 'nerves' 2.9 1 0 0.0 0 1 ERI1
Overall health rating 5.6 1 1 3.0 0 1 MST1R
Age at last live birth 8.9 1 1 3.0 0 1 MST1R
Leg pain on walking 4.1 1 0 0.0 0 1 MST1R
Knee pain experienced in last month 3.5 1 0 0.0 0 1 MST1R
Hypertension (Self-reported) 2.0 1 0 0.0 0 1 ERI1
Whole body fat-free mass 3.0 2 1 3.0 0 1 ERI1 MST1R
Leg fat-free mass (right) 3.1 2 1 3.0 0 1 ERI1 MST1R
Arm fat percentage (left) 4.0 2 1 3.0 0 1 ERI1 MST1R
Mood swings 6.1 2 0 0.0 0 1 ERI1 MST1R
Ever had bowel cancer screening 3.5 1 0 0.0 0 1 MST1R
Qualifications: nursing, teaching 3.0 1 0 0.0 0 1 MST1R
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.5 1 0 0.0 0 1 MST1R
Whole body water mass 3.1 2 1 3.0 0 1 ERI1 MST1R
Leg predicted mass (right) 3.1 2 1 3.0 0 1 ERI1 MST1R
Arm fat mass (left) 5.7 2 1 3.0 0 1 ERI1 MST1R
Miserableness 11.4 2 2 6.1 0 1 ERI1 MST1R
Guilty feelings 4.7 1 0 0.0 0 1 MST1R
Medication: Blood pressure 2.1 1 0 0.0 0 1 ERI1
Medication: Paracetamol 2.6 1 0 0.0 0 1 MST1R
Basal metabolic rate 3.5 2 1 3.0 0 1 ERI1 MST1R
Leg fat percentage (left) 4.4 1 1 3.0 0 1 MST1R
Arm fat-free mass (left) 3.9 1 1 3.0 0 1 MST1R
Number of operations (self-reported) 4.7 1 1 3.0 0 1 MST1R
Irritability 6.3 1 1 3.0 0 1 ERI1
Diastolic blood pressure, automated reading 2.9 2 0 0.0 0 1 ERI1 MST1R
Ever depressed for a whole week 4.4 1 0 0.0 0 1 MST1R
Vascular/heart problems diagnosed by doctor 1.9 1 0 0.0 0 1 ERI1
Pain experienced in last month 3.4 1 0 0.0 0 1 MST1R
Impedance of whole body 7.5 2 2 6.1 0 1 ERI1 MST1R
Leg fat mass (left) 5.9 1 1 3.0 0 1 MST1R
Arm predicted mass (left) 3.9 1 1 3.0 0 1 MST1R

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 3 0.0859 1.46
GTEx Adipose Visceral Omentum 2 0.0982 1.51
GTEx Adrenal Gland 1 0.0686 1.49
GTEx Artery Aorta 3 0.1008 1.46
GTEx Artery Coronary 1 0.0845 1.38
GTEx Artery Tibial 3 0.0798 1.49
GTEx Brain Caudate basal ganglia 2 0.2174 1.54
GTEx Brain Cerebellar Hemisphere 2 0.1343 1.58
GTEx Brain Cerebellum 4 0.2018 1.47
GTEx Brain Cortex 2 0.1932 1.49
GTEx Brain Frontal Cortex BA9 3 0.3247 1.57
GTEx Brain Hippocampus 0 0.0000 1.23
GTEx Brain Hypothalamus 0 0.0000 1.38
GTEx Brain Nucleus accumbens basal ganglia 1 0.1156 1.45
GTEx Brain Putamen basal ganglia 1 0.1603 1.41
GTEx Breast Mammary Tissue 2 0.1013 1.44
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.33
GTEx Breast Mammary Tissue (Female) 1 0.0608 1.36
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.42
GTEx Cells Transformed fibroblasts 2 0.0476 1.47
GTEx Colon Sigmoid 2 0.1368 1.40
GTEx Colon Transverse 1 0.0484 1.43
GTEx Esophagus Gastroesophageal Junction 2 0.1384 1.48
GTEx Esophagus Mucosa 3 0.0904 1.50
GTEx Esophagus Muscularis 3 0.0928 1.53
GTEx Heart Atrial Appendage 2 0.1267 1.52
GTEx Heart Left Ventricle 1 0.0654 1.52
GTEx Liver 1 0.1395 1.43
GTEx Lung 3 0.1044 1.48
GTEx Muscle Skeletal 2 0.0692 1.56
GTEx Nerve Tibial 2 0.0463 1.48
GTEx Ovary 0 0.0000 1.37
GTEx Pancreas 1 0.0613 1.56
GTEx Pituitary 1 0.0897 1.36
GTEx Prostate 1 0.1198 1.48
GTEx Skin Not Sun Exposed Suprapubic 3 0.1220 1.51
GTEx Skin Sun Exposed Lower leg 5 0.1374 1.47
GTEx Small Intestine Terminal Ileum 1 0.2169 1.63
GTEx Spleen 3 0.2126 1.49
GTEx Stomach 2 0.1376 1.50
GTEx Testis 4 0.1268 1.48
GTEx Thyroid 3 0.0750 1.46
GTEx Uterus 0 0.0000 1.41
GTEx Vagina 1 0.1575 1.55
GTEx Whole Blood 2 0.1004 1.45
METSIM Adipose 2 0.0434 1.41
NTR Blood 2 0.0833 1.41
ROSMAP Brain Pre-frontal Cortex 5 0.1139 1.49
YFS Blood 2 0.0433 1.42
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.46
TCGA Breast Tumor 0 0.0000 1.46
TCGA Breast Normal 3 0.0713 1.36
TCGA Ovarian Tumor 1 0.0342 1.46
TCGA Prostate Tumor 2 0.0578 1.47