Hub : Traits :

Frequency of unenthusiasm / disinterest in last 2 weeks

2 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 10 64531160 65911294 1 1 3.5e-09 4.0e-06 0.320 95 JMJD1C-AS1
2 14 69027866 70518587 1 1 3.2e-07 3.3e-07 0.028 81 GALNT16

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in father) 3.78 1 0 0.0 0 1 JMJD1C-AS1
Verbal and Numeric Reasoning (VNR) 8.16 2 1 3.0 0 1 GALNT16 JMJD1C-AS1
Breast Cancer 2.62 1 0 0.0 0 1 JMJD1C-AS1
Ovarian Cancer 2.40 1 0 0.0 0 1 GALNT16
HDL Cholesterol 2.27 1 0 0.0 0 1 JMJD1C-AS1
Lupus 1.72 1 0 0.0 0 1 GALNT16
Triglycerides 4.24 1 0 0.0 0 1 JMJD1C-AS1
Blood Eosinophil Count 0.51 1 0 0.0 0 1 GALNT16
Blood Platelet Count 2.30 1 1 3.0 0 1 JMJD1C-AS1
Blood Red Count 1.37 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Blood White Count 3.87 1 1 3.0 0 1 JMJD1C-AS1
BMI 3.31 2 1 3.0 0 1 GALNT16 JMJD1C-AS1
Height 0.47 1 0 0.0 0 1 JMJD1C-AS1
Waist Hip Ratio (WHR) 1.45 1 0 0.0 0 1 JMJD1C-AS1
Smoking Status 2.12 1 0 0.0 0 1 JMJD1C-AS1
Allergy or Eczema 1.71 1 0 0.0 0 1 GALNT16
Lung FEV1/FVC ratio 1.90 1 0 0.0 0 1 JMJD1C-AS1
Lung FVC 2.15 1 0 0.0 0 1 JMJD1C-AS1
Neuroticism 7.11 1 1 3.0 0 1 GALNT16
Hair Pigment 0.43 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Number of treatments/medications taken 3.37 1 0 0.0 0 1 GALNT16
Sensitivity / hurt feelings 4.96 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Frequency of depressed mood in last 2 weeks 14.15 2 1 3.0 0 1 GALNT16 JMJD1C-AS1
Ever used hormone-replacement therapy (HRT) 2.54 1 0 0.0 0 1 JMJD1C-AS1
Eye problems/disorders: Diabetes related eye disease 3.47 1 0 0.0 0 1 GALNT16
Vitamin and mineral supplements 2.83 1 0 0.0 0 1 JMJD1C-AS1
Supplements: Zinc 2.62 1 0 0.0 0 1 GALNT16
Pack years adult smoking proportion 11.06 1 1 3.0 0 1 JMJD1C-AS1
Impedance of leg (right) 1.67 1 0 0.0 0 1 JMJD1C-AS1
Trunk fat percentage 2.25 1 0 0.0 0 1 GALNT16
Townsend deprivation index at recruitment 3.56 1 0 0.0 0 1 JMJD1C-AS1
Current tobacco smoking 6.68 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Maternal smoking around birth 2.41 1 0 0.0 0 1 GALNT16
Fed-up feelings 8.13 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Relative age voice broke 1.65 1 0 0.0 0 1 GALNT16
Qualifications: CSEs or equivalent 6.71 1 0 0.0 0 1 JMJD1C-AS1
Hayfever, allergic rhinitis or eczema 1.51 1 0 0.0 0 1 GALNT16
Stomach or abdominal pain in last month 4.12 1 0 0.0 0 1 JMJD1C-AS1
Body mass index (BMI) 3.40 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Impedance of leg (left) 1.56 1 0 0.0 0 1 JMJD1C-AS1
Trunk fat mass 2.18 1 0 0.0 0 1 GALNT16
Waist circumference 2.72 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Number of incorrect matches in round 3.09 1 0 0.0 0 1 JMJD1C-AS1
Alcohol usually taken with meals 5.64 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Nervous feelings 1.97 1 0 0.0 0 1 GALNT16
Frequency of tenseness / restlessness in last 2 weeks 7.11 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Qualifications: None of the above 13.12 2 1 3.0 0 1 GALNT16 JMJD1C-AS1
Financial difficulties in last 2 years 6.53 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Heart attack 4.23 1 0 0.0 0 1 GALNT16
Diabetes (self-reported) 2.07 1 0 0.0 0 1 GALNT16
Fluid intelligence score 7.42 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Neuroticism score 8.49 2 1 3.0 0 1 GALNT16 JMJD1C-AS1
Weight 1.70 1 0 0.0 0 1 GALNT16
Impedance of arm (right) 4.05 1 1 3.0 0 1 JMJD1C-AS1
Arm fat percentage (right) 2.12 1 0 0.0 0 1 GALNT16
Trunk fat-free mass 0.77 1 0 0.0 0 1 JMJD1C-AS1
Hip circumference 1.19 1 0 0.0 0 1 GALNT16
Worrier / anxious feelings 2.48 1 0 0.0 0 1 GALNT16
Frequency of tiredness / lethargy in last 2 weeks 13.99 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Pulse rate 1.99 1 0 0.0 0 1 GALNT16
Qualifications: A levels/AS levels or equivalent 7.20 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Mouth/teeth dental problems: Dentures 3.05 1 0 0.0 0 1 GALNT16
Medication: Cholesterol lowering 2.64 1 0 0.0 0 1 GALNT16
Medication: Lansoprazole 7.46 1 0 0.0 0 1 GALNT16
Prospective memory result 2.42 1 0 0.0 0 1 GALNT16
Forced expiratory volume in 1-second (FEV1), Best measure 1.28 1 0 0.0 0 1 JMJD1C-AS1
Pulse wave Arterial Stiffness index 4.08 1 0 0.0 0 1 JMJD1C-AS1
Impedance of arm (left) 4.99 2 1 3.0 0 1 GALNT16 JMJD1C-AS1
Arm fat mass (right) 2.24 1 0 0.0 0 1 GALNT16
Trunk predicted mass 0.76 1 0 0.0 0 1 JMJD1C-AS1
Standing height 0.50 1 0 0.0 0 1 JMJD1C-AS1
Tense / 'highly strung' 2.21 1 0 0.0 0 1 JMJD1C-AS1
Ever highly irritable/argumentative for 2 days 6.00 1 0 0.0 0 1 JMJD1C-AS1
Loud music exposure frequency 5.07 1 0 0.0 0 1 JMJD1C-AS1
Qualifications: O levels/GCSEs or equivalent 5.63 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Medication: Paracetamol 6.44 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Headache pain in last month 3.87 1 0 0.0 0 1 GALNT16
Body fat percentage 3.03 1 0 0.0 0 1 GALNT16
Leg fat percentage (right) 4.66 1 1 3.0 0 1 GALNT16
Arm fat-free mass (right) 1.44 1 0 0.0 0 1 JMJD1C-AS1
Exposure to tobacco smoke outside home 7.84 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Reason for reducing amount of alcohol drunk: Health precaution 3.25 1 0 0.0 0 1 GALNT16
Age at first live birth 4.76 1 0 0.0 0 1 JMJD1C-AS1
Pulse wave peak to peak time 4.86 1 0 0.0 0 1 JMJD1C-AS1
Qualifications: College or University degree 12.93 2 2 6.1 0 1 GALNT16 JMJD1C-AS1
Eye problems/disorders: None of the above 2.94 1 0 0.0 0 1 JMJD1C-AS1
Emphysema/chronic bronchitis 4.82 1 0 0.0 0 1 GALNT16
Medication for pain relief, constipation, heartburn 5.69 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Neck or shoulder pain in last month 4.95 1 0 0.0 0 1 GALNT16
Whole body fat mass 2.75 1 0 0.0 0 1 GALNT16
Leg fat mass (right) 3.94 1 1 3.0 0 1 GALNT16
Arm predicted mass (right) 1.42 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Alcohol intake frequency. 4.97 1 0 0.0 0 1 GALNT16
Number of full sisters 4.57 1 0 0.0 0 1 GALNT16
Overall health rating 9.59 2 1 3.0 0 1 GALNT16 JMJD1C-AS1
Qualifications: NVQ or HND or HNC or equivalent 2.41 1 0 0.0 0 1 GALNT16
Illness, injury, bereavement, stress in last 2 years 5.32 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Knee pain experienced in last month 6.48 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Whole body fat-free mass 0.84 1 0 0.0 0 1 JMJD1C-AS1
Arm fat percentage (left) 1.70 1 0 0.0 0 1 GALNT16
Average weekly red wine intake 3.49 1 0 0.0 0 1 JMJD1C-AS1
Mood swings 8.47 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Loneliness, isolation 13.26 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Diabetes diagnosed by doctor 2.44 1 0 0.0 0 1 GALNT16
Qualifications: nursing, teaching 11.85 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Eye problems/disorders: Cataract 4.89 1 0 0.0 0 1 JMJD1C-AS1
Back pain experienced in last month 5.43 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Osteoporosis (self-reported) 2.22 1 0 0.0 0 1 GALNT16
Osteoarthritis (self-reported) 2.66 1 0 0.0 0 1 GALNT16
Smoking status: Current 6.73 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.01 1 0 0.0 0 1 JMJD1C-AS1
Whole body water mass 0.88 1 0 0.0 0 1 JMJD1C-AS1
Arm fat mass (left) 1.96 1 0 0.0 0 1 GALNT16
Average weekly champagne plus white wine intake 3.42 1 0 0.0 0 1 GALNT16
Miserableness 4.12 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Guilty feelings 3.03 1 0 0.0 0 1 GALNT16
Financial situation satisfaction 5.34 1 0 0.0 0 1 GALNT16
Pain type(s) experienced in last month: Hip pain 3.16 1 0 0.0 0 1 JMJD1C-AS1
Medication: Bendroflumethiazide 2.14 1 0 0.0 0 1 GALNT16
Medication: Paracetamol 4.55 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Medication: Atorvastatin 2.26 1 0 0.0 0 1 JMJD1C-AS1
Basal metabolic rate 0.98 1 0 0.0 0 1 JMJD1C-AS1
Leg fat percentage (left) 4.80 1 1 3.0 0 1 GALNT16
Arm fat-free mass (left) 2.06 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Average weekly beer plus cider intake 3.89 2 0 0.0 0 1 GALNT16 JMJD1C-AS1
Unable to work because of sickness or disability 4.55 1 0 0.0 0 1 JMJD1C-AS1
Vascular/heart problems diagnosed by doctor 1.25 1 0 0.0 0 1 GALNT16
Pain experienced in last month 5.02 1 0 0.0 0 1 GALNT16
Heart attack/myocardial infarction (self-reported) 4.36 1 0 0.0 0 1 GALNT16
Pack years of smoking 9.86 1 1 3.0 0 1 JMJD1C-AS1
Impedance of whole body 3.22 1 1 3.0 0 1 JMJD1C-AS1
Leg fat mass (left) 3.88 1 1 3.0 0 1 GALNT16
Arm predicted mass (left) 2.03 2 0 0.0 0 1 GALNT16 JMJD1C-AS1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.32
GTEx Adipose Visceral Omentum 0 0.0000 1.38
GTEx Adrenal Gland 0 0.0000 1.29
GTEx Artery Aorta 0 0.0000 1.36
GTEx Artery Coronary 0 0.0000 1.41
GTEx Artery Tibial 0 0.0000 1.40
GTEx Brain Caudate basal ganglia 0 0.0000 1.30
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.32
GTEx Brain Cerebellum 0 0.0000 1.37
GTEx Brain Cortex 0 0.0000 1.31
GTEx Brain Frontal Cortex BA9 0 0.0000 1.26
GTEx Brain Hippocampus 0 0.0000 1.29
GTEx Brain Hypothalamus 0 0.0000 1.32
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.24
GTEx Brain Putamen basal ganglia 0 0.0000 1.34
GTEx Breast Mammary Tissue 0 0.0000 1.43
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.38
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.40
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.34
GTEx Cells Transformed fibroblasts 0 0.0000 1.38
GTEx Colon Sigmoid 0 0.0000 1.37
GTEx Colon Transverse 0 0.0000 1.36
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.36
GTEx Esophagus Mucosa 0 0.0000 1.36
GTEx Esophagus Muscularis 0 0.0000 1.38
GTEx Heart Atrial Appendage 0 0.0000 1.42
GTEx Heart Left Ventricle 0 0.0000 1.34
GTEx Liver 0 0.0000 1.32
GTEx Lung 0 0.0000 1.40
GTEx Muscle Skeletal 0 0.0000 1.36
GTEx Nerve Tibial 0 0.0000 1.38
GTEx Ovary 0 0.0000 1.28
GTEx Pancreas 0 0.0000 1.35
GTEx Pituitary 0 0.0000 1.34
GTEx Prostate 0 0.0000 1.34
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.42
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.40
GTEx Small Intestine Terminal Ileum 0 0.0000 1.31
GTEx Spleen 1 0.0709 1.37
GTEx Stomach 0 0.0000 1.35
GTEx Testis 1 0.0317 1.37
GTEx Thyroid 0 0.0000 1.37
GTEx Uterus 0 0.0000 1.39
GTEx Vagina 0 0.0000 1.24
GTEx Whole Blood 0 0.0000 1.35
METSIM Adipose 0 0.0000 1.28
NTR Blood 0 0.0000 1.31
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.38
YFS Blood 0 0.0000 1.26
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.32
TCGA Breast Tumor 0 0.0000 1.33
TCGA Breast Normal 0 0.0000 1.28
TCGA Ovarian Tumor 0 0.0000 1.31
TCGA Prostate Tumor 0 0.0000 1.29