Hub : Traits :

Medication: Atorvastatin

36 significantly associated models · 20 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 108854166 110733794 4 1 3.8e-29 6.6e-29 1.0e+00 100 PSRC1
2 2 20529948 21958745 1 1 4.7e-12 2.1e-12 1.0e+00 100 APOB
3 2 26854065 28414302 5 4 6.0e-10 3.1e-14 NaN NaN AC074117.10 FNDC4
4 5 73969058 75594743 3 1 3.3e-12 2.1e-12 2.2e-03 81 COL4A3BP
5 9 21303958 22705094 1 1 2.7e-07 9.2e-10 1.4e-04 61 CDKN2B
6 11 115953897 117745003 2 2 4.0e-20 1.3e-22 7.3e-01 100 PAFAH1B2 ZNF259
7 19 10377885 12191233 3 2 2.2e-09 2.4e-29 5.7e-16 48 C19orf80 EPOR
8 19 44704753 46098885 1 1 3.9e-08 4.9e-36 5.6e-34 6 TOMM40

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in mother) 6.17 1 1 3.0 0.00 1.0e+00 TOMM40
Alzheimer’s Disease (in father) 1.75 1 0 0.0 0.00 1.0e+00 TOMM40
Alzheimer’s Disease (including proxy) 11.90 1 1 3.0 0.00 1.0e+00 TOMM40
Crohns Disease (2017) 3.58 2 1 3.0 1.00 2.6e-03 AC074117.10 FNDC4
Irritable Bowel Disease (IBD) 3.04 1 1 3.0 0.00 1.0e+00 AC074117.10
Breast Cancer 1.24 1 0 0.0 0.00 1.0e+00 CDKN2B
Bipolar Disorder 3.40 1 0 0.0 0.00 1.0e+00 FNDC4
Coronary Artery Disease (CAD) 13.17 5 3 9.1 -0.95 1.2e-02 CDKN2B EPOR PAFAH1B2 PSRC1 ZNF259
Fasting Glucose 11.24 2 2 6.1 1.00 2.1e-03 AC074117.10 FNDC4
HDL Cholesterol 9.05 5 2 6.1 0.89 4.1e-02 APOB PAFAH1B2 PSRC1 TOMM40 ZNF259
LDL Cholesterol 98.39 8 8 24.2 -0.91 1.8e-03 APOB C19orf80 COL4A3BP EPOR PAFAH1B2 PSRC1 TOMM40 ZNF259
Primary Biliary Cirrhosis 3.37 1 0 0.0 0.00 1.0e+00 EPOR
Triglycerides 103.60 5 5 15.2 -0.96 5.1e-04 AC074117.10 APOB FNDC4 PAFAH1B2 ZNF259
Type 2 Diabetes (T2D) 1.79 1 0 0.0 0.00 1.0e+00 CDKN2B
Ulcerative Colitis 2.74 2 0 0.0 0.00 1.0e+00 AC074117.10 PAFAH1B2
Blood Eosinophil Count 2.00 5 2 6.1 0.09 8.8e-01 EPOR FNDC4 PAFAH1B2 TOMM40 ZNF259
Blood Platelet Count 10.15 7 6 18.2 -0.36 3.5e-01 AC074117.10 CDKN2B COL4A3BP FNDC4 PAFAH1B2 TOMM40 ZNF259
Blood Red Count 0.87 1 1 3.0 0.00 1.0e+00 FNDC4
Blood White Count 6.59 5 2 6.1 -0.72 6.7e-02 AC074117.10 CDKN2B EPOR FNDC4 PAFAH1B2
Heel T-Score 0.92 3 0 0.0 0.00 1.0e+00 APOB PSRC1 TOMM40
BMI 1.88 2 1 3.0 0.00 1.0e+00 COL4A3BP FNDC4
Height 1.99 6 4 12.1 0.92 1.2e-03 AC074117.10 EPOR FNDC4 PSRC1 TOMM40 ZNF259
Systolic Blood Pressure 1.98 4 1 3.0 -0.99 1.0e-04 AC074117.10 EPOR PAFAH1B2 TOMM40
Smoking Status 1.03 1 0 0.0 0.00 1.0e+00 PSRC1
Allergy or Eczema 1.91 1 0 0.0 0.00 1.0e+00 AC074117.10
Cardiovascular Disease 12.63 9 7 21.2 -0.99 1.7e-08 AC074117.10 APOB COL4A3BP EPOR FNDC4 PAFAH1B2 PSRC1 TOMM40 ZNF259
Type 2 Diabetes (T2D) 6.62 2 1 3.0 1.00 2.3e-03 AC074117.10 FNDC4
Lung FEV1/FVC ratio 0.73 1 1 3.0 0.00 1.0e+00 PSRC1
Lung FVC 0.72 1 0 0.0 0.00 1.0e+00 FNDC4
Hair Pigment 0.77 3 2 6.1 -0.47 4.2e-01 AC074117.10 CDKN2B EPOR
Tanning 0.78 3 1 3.0 0.72 1.7e-01 AC074117.10 EPOR FNDC4
Number of treatments/medications taken 5.95 4 1 3.0 0.99 1.5e-04 AC074117.10 PSRC1 TOMM40 ZNF259
Hearing difficulty/problems: Yes 1.56 1 0 0.0 0.00 1.0e+00 PSRC1
Relative age of first facial hair 1.95 2 0 0.0 0.00 1.0e+00 AC074117.10 FNDC4
Other serious medical condition/disability diagnosed by doctor 1.76 1 0 0.0 0.00 1.0e+00 PSRC1
Ever used hormone-replacement therapy (HRT) 2.62 1 0 0.0 0.00 1.0e+00 AC074117.10
Systolic blood pressure, automated reading 1.29 2 0 0.0 0.00 1.0e+00 AC074117.10 EPOR
Angina 12.55 3 2 6.1 0.00 1.0e+00 C19orf80 CDKN2B PSRC1
Medication: Metformin 4.59 2 0 0.0 -0.48 5.2e-01 AC074117.10 CDKN2B
Diabetes (father) 3.97 2 0 0.0 0.00 1.0e+00 AC074117.10 FNDC4
Diabetes (mother) 2.87 1 0 0.0 0.00 1.0e+00 FNDC4
Impedance of leg (right) 2.39 3 1 3.0 0.00 1.0e+00 AC074117.10 COL4A3BP FNDC4
Leg fat-free mass (left) 4.16 5 3 9.1 -0.87 1.0e-02 AC074117.10 COL4A3BP EPOR FNDC4 PSRC1
Trunk fat percentage 0.91 1 0 0.0 0.00 1.0e+00 COL4A3BP
Hand grip strength (right) 1.34 1 0 0.0 0.00 1.0e+00 AC074117.10
High blood pressure 1.42 1 0 0.0 0.00 1.0e+00 AC074117.10
Hayfever, allergic rhinitis or eczema 2.29 1 0 0.0 0.00 1.0e+00 AC074117.10
Stomach or abdominal pain in last month 2.60 1 0 0.0 0.00 1.0e+00 AC074117.10
Medication: Atenolol 2.75 1 0 0.0 0.00 1.0e+00 CDKN2B
Sitting height 2.38 2 2 6.1 -1.00 2.5e-04 AC074117.10 FNDC4
Body mass index (BMI) 1.40 2 1 3.0 0.00 1.0e+00 COL4A3BP FNDC4
Impedance of leg (left) 2.39 3 1 3.0 0.00 1.0e+00 AC074117.10 COL4A3BP FNDC4
Leg predicted mass (left) 4.13 5 3 9.1 -0.88 9.5e-03 AC074117.10 COL4A3BP EPOR FNDC4 PSRC1
Trunk fat mass 1.38 1 1 3.0 0.00 1.0e+00 COL4A3BP
Waist circumference 1.59 2 1 3.0 0.00 1.0e+00 AC074117.10 COL4A3BP
Number of incorrect matches in round 0.98 1 0 0.0 0.00 1.0e+00 FNDC4
Had menopause 7.26 1 1 3.0 0.00 1.0e+00 AC074117.10
Forced vital capacity (FVC) 0.65 1 0 0.0 0.00 1.0e+00 EPOR
Heart attack 8.70 3 2 6.1 0.00 1.0e+00 C19orf80 CDKN2B PSRC1
Diabetes (self-reported) 5.43 1 1 3.0 0.00 1.0e+00 AC074117.10
Medication: Simvastatin 32.34 11 8 24.2 0.97 5.2e-08 AC074117.10 APOB C19orf80 CDKN2B COL4A3BP EPOR FNDC4 PAFAH1B2 PSRC1 TOMM40 ZNF259
Weight 2.94 4 3 9.1 -0.99 2.1e-04 AC074117.10 COL4A3BP EPOR FNDC4
Impedance of arm (right) 3.82 4 2 6.1 0.80 5.7e-02 AC074117.10 CDKN2B COL4A3BP FNDC4
Arm fat percentage (right) 0.97 1 1 3.0 0.00 1.0e+00 COL4A3BP
Trunk fat-free mass 5.83 5 5 15.2 -0.88 8.9e-03 AC074117.10 COL4A3BP EPOR FNDC4 PSRC1
Hip circumference 1.72 4 1 3.0 -0.96 4.3e-02 AC074117.10 COL4A3BP EPOR FNDC4
Alcohol intake versus 10 years previously 5.24 2 1 3.0 1.00 1.7e-03 AC074117.10 FNDC4
Father's age at death 3.18 2 0 0.0 0.00 1.0e+00 CDKN2B PSRC1
Forced expiratory volume in 1-second (FEV1) 0.81 1 0 0.0 0.00 1.0e+00 EPOR
Pulse rate 4.19 2 0 0.0 1.00 2.8e-04 AC074117.10 FNDC4
Mouth/teeth dental problems: Dentures 1.76 1 0 0.0 0.00 1.0e+00 FNDC4
Medication: Cholesterol lowering 43.12 11 10 30.3 0.98 3.2e-09 AC074117.10 APOB C19orf80 CDKN2B COL4A3BP EPOR FNDC4 PAFAH1B2 PSRC1 TOMM40 ZNF259
Illnesses of mother 2.37 1 0 0.0 0.00 1.0e+00 CDKN2B
Forced expiratory volume in 1-second (FEV1), Best measure 0.88 1 0 0.0 0.00 1.0e+00 EPOR
Pulse wave Arterial Stiffness index 1.64 1 0 0.0 0.00 1.0e+00 TOMM40
Impedance of arm (left) 3.95 3 2 6.1 0.92 2.8e-02 AC074117.10 COL4A3BP FNDC4
Arm fat mass (right) 1.66 1 1 3.0 0.00 1.0e+00 COL4A3BP
Trunk predicted mass 5.87 5 5 15.2 -0.88 8.5e-03 AC074117.10 COL4A3BP EPOR FNDC4 PSRC1
Standing height 2.09 4 3 9.1 -0.94 5.5e-03 AC074117.10 EPOR FNDC4 PSRC1
Breastfed as a baby 1.68 1 0 0.0 0.00 1.0e+00 C19orf80
Birth weight of first child 1.79 1 0 0.0 0.00 1.0e+00 EPOR
Peak expiratory flow (PEF) 0.89 1 0 0.0 0.00 1.0e+00 EPOR
Medication: Paracetamol 2.32 1 0 0.0 0.00 1.0e+00 AC074117.10
Headache pain in last month 2.39 1 0 0.0 0.00 1.0e+00 AC074117.10
Medication for cholesterol, blood pressure or diabetes 15.15 9 5 15.2 -0.99 6.1e-08 AC074117.10 APOB C19orf80 COL4A3BP EPOR PAFAH1B2 PSRC1 TOMM40 ZNF259
Glaucoma (self-reported) 3.75 1 1 3.0 0.00 1.0e+00 CDKN2B
Gout (self-reported) 16.91 3 2 6.1 0.92 2.8e-02 AC074117.10 FNDC4 ZNF259
High blood pressure (siblings) 2.39 1 0 0.0 0.00 1.0e+00 AC074117.10
Forced vital capacity (FVC), Best measure 0.83 1 0 0.0 0.00 1.0e+00 EPOR
Body fat percentage 0.97 1 1 3.0 0.00 1.0e+00 COL4A3BP
Leg fat percentage (right) 0.94 1 1 3.0 0.00 1.0e+00 COL4A3BP
Arm fat-free mass (right) 5.78 5 3 9.1 -0.89 7.2e-03 AC074117.10 COL4A3BP EPOR FNDC4 PSRC1
Comparative body size at age 10 1.47 1 0 0.0 0.00 1.0e+00 AC074117.10
Medication for pain relief, constipation, heartburn 2.42 2 0 0.0 0.00 1.0e+00 AC074117.10 PSRC1
Medication: Blood pressure 1.63 1 0 0.0 0.00 1.0e+00 PAFAH1B2
Angina (self-reported) 12.67 3 2 6.1 0.00 1.0e+00 C19orf80 CDKN2B PSRC1
Medication: Allopurinol 12.98 2 2 6.1 1.00 2.9e-03 AC074117.10 FNDC4
Heart disease (mother) 5.16 2 1 3.0 0.00 1.0e+00 CDKN2B ZNF259
Whole body fat mass 1.44 1 1 3.0 0.00 1.0e+00 COL4A3BP
Leg fat mass (right) 1.75 2 1 3.0 0.00 1.0e+00 AC074117.10 COL4A3BP
Arm predicted mass (right) 5.66 5 3 9.1 -0.88 8.2e-03 AC074117.10 COL4A3BP EPOR FNDC4 PSRC1
Pulse rate, automated reading 6.27 3 2 6.1 0.72 1.7e-01 AC074117.10 APOB FNDC4
Alcohol intake frequency. 11.74 2 2 6.1 1.00 1.6e-03 AC074117.10 FNDC4
Comparative height size at age 10 2.51 3 2 6.1 -0.91 3.4e-02 AC074117.10 FNDC4 PSRC1
Overall health rating 1.97 1 0 0.0 0.00 1.0e+00 AC074117.10
Chest pain or discomfort 1.95 1 0 0.0 0.00 1.0e+00 CDKN2B
Medication: Aspirin 8.82 5 2 6.1 0.98 3.4e-03 APOB C19orf80 CDKN2B EPOR PSRC1
Illnesses of father: Heart disease 11.62 4 2 6.1 0.94 6.5e-02 C19orf80 CDKN2B EPOR PSRC1
Forced expiratory volume in 1-second (FEV1), predicted 1.39 1 0 0.0 0.00 1.0e+00 EPOR
Whole body fat-free mass 5.40 5 4 12.1 -0.88 8.8e-03 AC074117.10 COL4A3BP EPOR FNDC4 PSRC1
Leg fat-free mass (right) 4.13 5 3 9.1 -0.88 9.8e-03 AC074117.10 COL4A3BP EPOR FNDC4 PSRC1
Arm fat percentage (left) 0.87 1 1 3.0 0.00 1.0e+00 COL4A3BP
Long-standing illness, disability or infirmity 1.75 1 0 0.0 0.00 1.0e+00 CDKN2B
Diabetes diagnosed by doctor 6.16 2 1 3.0 -0.99 5.0e-03 AC074117.10 FNDC4
Eye problems/disorders: Cataract 2.38 1 0 0.0 0.00 1.0e+00 AC074117.10
Medication for cholesterol 8.02 6 1 3.0 -0.97 2.0e-04 AC074117.10 COL4A3BP FNDC4 PAFAH1B2 PSRC1 TOMM40
Back pain experienced in last month 1.52 1 0 0.0 0.00 1.0e+00 APOB
Breast cancer (self-reported) 1.53 1 0 0.0 0.00 1.0e+00 CDKN2B
Osteoporosis (self-reported) 2.40 1 0 0.0 0.00 1.0e+00 AC074117.10
Medication: Aspirin 8.68 5 2 6.1 0.97 6.3e-03 C19orf80 CDKN2B EPOR PSRC1 TOMM40
Illnesses of father: None of the above (group 1) 3.76 1 1 3.0 0.00 1.0e+00 CDKN2B
Whole body water mass 5.45 5 3 9.1 -0.88 9.4e-03 AC074117.10 COL4A3BP EPOR FNDC4 PSRC1
Leg predicted mass (right) 4.16 5 3 9.1 -0.88 9.8e-03 AC074117.10 COL4A3BP EPOR FNDC4 PSRC1
Arm fat mass (left) 1.56 1 1 3.0 0.00 1.0e+00 COL4A3BP
Number of self-reported non-cancer illnesses 5.68 4 0 0.0 0.96 2.8e-03 AC074117.10 FNDC4 PSRC1 ZNF259
Eye problems/disorders: Glaucoma 4.92 1 1 3.0 0.00 1.0e+00 CDKN2B
High cholesterol (Self-reported) 74.58 10 10 30.3 0.98 8.2e-09 AC074117.10 APOB C19orf80 COL4A3BP EPOR FNDC4 PAFAH1B2 PSRC1 TOMM40 ZNF259
Basal metabolic rate 4.76 5 3 9.1 -0.88 8.7e-03 AC074117.10 COL4A3BP EPOR FNDC4 PSRC1
Leg fat percentage (left) 0.83 1 1 3.0 0.00 1.0e+00 COL4A3BP
Arm fat-free mass (left) 5.38 5 3 9.1 -0.88 9.4e-03 AC074117.10 COL4A3BP EPOR FNDC4 PSRC1
Diastolic blood pressure, automated reading 1.21 2 0 0.0 0.00 1.0e+00 C19orf80 CDKN2B
Vascular/heart problems diagnosed by doctor 2.17 2 0 0.0 0.00 1.0e+00 AC074117.10 CDKN2B
Cholesterol lowering medication 37.07 11 10 30.3 0.99 4.5e-10 AC074117.10 APOB C19orf80 CDKN2B COL4A3BP EPOR FNDC4 PAFAH1B2 PSRC1 TOMM40 ZNF259
Pain experienced in last month 1.62 1 0 0.0 0.00 1.0e+00 APOB
Basal cell carcinoma (self-reported) 1.99 1 0 0.0 0.00 1.0e+00 CDKN2B
Heart attack/myocardial infarction (self-reported) 8.68 3 2 6.1 0.00 1.0e+00 C19orf80 CDKN2B PSRC1
Heart disease (siblings) 3.89 3 0 0.0 0.00 1.0e+00 CDKN2B PSRC1 ZNF259
Alcohol drinker status: Previous 2.04 1 0 0.0 0.00 1.0e+00 APOB
Impedance of whole body 3.71 4 3 9.1 0.78 1.2e-01 AC074117.10 COL4A3BP FNDC4 PSRC1
Leg fat mass (left) 1.75 2 1 3.0 0.00 1.0e+00 AC074117.10 COL4A3BP
Arm predicted mass (left) 5.45 5 4 12.1 -0.89 7.8e-03 AC074117.10 COL4A3BP EPOR FNDC4 PSRC1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0573 1.23
GTEx Adipose Visceral Omentum 0 0.0000 1.27
GTEx Adrenal Gland 0 0.0000 1.22
GTEx Artery Aorta 0 0.0000 1.27
GTEx Artery Coronary 0 0.0000 1.22
GTEx Artery Tibial 0 0.0000 1.27
GTEx Brain Caudate basal ganglia 0 0.0000 1.15
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.26
GTEx Brain Cerebellum 0 0.0000 1.33
GTEx Brain Cortex 0 0.0000 1.20
GTEx Brain Frontal Cortex BA9 0 0.0000 1.19
GTEx Brain Hippocampus 0 0.0000 1.13
GTEx Brain Hypothalamus 0 0.0000 1.20
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.11
GTEx Brain Putamen basal ganglia 0 0.0000 1.14
GTEx Breast Mammary Tissue 0 0.0000 1.19
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.17
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.19
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.19
GTEx Cells Transformed fibroblasts 2 0.0476 1.26
GTEx Colon Sigmoid 0 0.0000 1.17
GTEx Colon Transverse 0 0.0000 1.25
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.15
GTEx Esophagus Mucosa 3 0.0904 1.29
GTEx Esophagus Muscularis 1 0.0309 1.23
GTEx Heart Atrial Appendage 0 0.0000 1.18
GTEx Heart Left Ventricle 0 0.0000 1.16
GTEx Liver 2 0.2789 1.46
GTEx Lung 0 0.0000 1.17
GTEx Muscle Skeletal 1 0.0346 1.27
GTEx Nerve Tibial 0 0.0000 1.22
GTEx Ovary 1 0.1101 1.41
GTEx Pancreas 0 0.0000 1.23
GTEx Pituitary 0 0.0000 1.28
GTEx Prostate 0 0.0000 1.24
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.22
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.29
GTEx Small Intestine Terminal Ileum 0 0.0000 1.24
GTEx Spleen 1 0.0709 1.34
GTEx Stomach 0 0.0000 1.32
GTEx Testis 2 0.0634 1.21
GTEx Thyroid 2 0.0500 1.28
GTEx Uterus 0 0.0000 1.16
GTEx Vagina 1 0.1575 1.24
GTEx Whole Blood 1 0.0502 1.36
METSIM Adipose 1 0.0217 1.21
NTR Blood 1 0.0416 1.26
ROSMAP Brain Pre-frontal Cortex 3 0.0683 1.32
YFS Blood 2 0.0433 1.25
CommonMind Brain Pre-frontal Cortex 7 0.1302 1.30
TCGA Breast Tumor 0 0.0000 1.11
TCGA Breast Normal 1 0.0238 1.22
TCGA Ovarian Tumor 1 0.0342 1.28
TCGA Prostate Tumor 0 0.0000 1.24