Hub : Traits :

Exposure to tobacco smoke at home

15 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 49030828 50546340 3 1 3.5e-09 1.6e-06 0.57 99 RNF123

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 6.15 1 0 0 0 1 RNF123
Irritable Bowel Disease (IBD) 11.56 1 1 3 0 1 RNF123
Ulcerative Colitis (UC) 13.59 1 1 3 0 1 RNF123
Major Depression (MDD) 13.08 1 0 0 0 1 RNF123
Verbal and Numeric Reasoning (VNR) 24.05 1 1 3 0 1 RNF123
Breast Cancer 4.70 1 0 0 0 1 RNF123
Prostate Cancer 10.78 1 0 0 0 1 RNF123
Age at First Birth 40.53 1 1 3 0 1 RNF123
Body Mass Index (BMI) (2010) 6.56 1 0 0 0 1 RNF123
Neuroticism 6.99 1 0 0 0 1 RNF123
Blood Eosinophil Count 1.78 1 0 0 0 1 RNF123
Blood White Count 7.69 1 1 3 0 1 RNF123
BMI 27.57 1 1 3 0 1 RNF123
Height 0.49 1 0 0 0 1 RNF123
Systolic Blood Pressure 3.25 1 0 0 0 1 RNF123
Smoking Status 9.42 1 0 0 0 1 RNF123
Respiratory disease 9.32 1 0 0 0 1 RNF123
Type 2 Diabetes (T2D) 11.85 1 0 0 0 1 RNF123
Lung FEV1/FVC ratio 3.23 1 0 0 0 1 RNF123
Lung FVC 5.83 1 1 3 0 1 RNF123
Neuroticism 10.49 1 1 3 0 1 RNF123
Chronotype (morning person) 5.23 1 0 0 0 1 RNF123
Number of treatments/medications taken 25.43 1 1 3 0 1 RNF123
Relative age of first facial hair 4.16 1 0 0 0 1 RNF123
Systolic blood pressure, automated reading 5.16 1 0 0 0 1 RNF123
Medication: Co-codamol 20.65 1 0 0 0 1 RNF123
Pack years adult smoking proportion 5.81 1 0 0 0 1 RNF123
Impedance of leg (right) 8.59 1 1 3 0 1 RNF123
Leg fat-free mass (left) 10.98 1 1 3 0 1 RNF123
Trunk fat percentage 11.44 1 1 3 0 1 RNF123
Maternal smoking around birth 10.69 1 0 0 0 1 RNF123
Fed-up feelings 18.96 1 1 3 0 1 RNF123
Frequency of unenthusiasm / disinterest in last 2 weeks 10.75 1 0 0 0 1 RNF123
Taking other prescription medications 28.29 1 1 3 0 1 RNF123
Age when periods started (menarche) 8.55 1 0 0 0 1 RNF123
Bilateral oophorectomy (both ovaries removed) 8.43 1 0 0 0 1 RNF123
Qualifications: CSEs or equivalent 11.73 1 0 0 0 1 RNF123
Body mass index (BMI) 31.84 1 1 3 0 1 RNF123
Impedance of leg (left) 10.07 1 1 3 0 1 RNF123
Leg predicted mass (left) 10.81 1 1 3 0 1 RNF123
Trunk fat mass 16.42 1 1 3 0 1 RNF123
Waist circumference 17.66 1 1 3 0 1 RNF123
Alcohol usually taken with meals 6.88 1 0 0 0 1 RNF123
Frequency of tenseness / restlessness in last 2 weeks 12.77 1 0 0 0 1 RNF123
Hair/balding pattern: Pattern 2 6.84 1 0 0 0 1 RNF123
Forced vital capacity (FVC) 5.96 1 0 0 0 1 RNF123
Ever unenthusiastic/disinterested for a whole week 16.56 1 0 0 0 1 RNF123
Qualifications: None of the above 28.10 1 1 3 0 1 RNF123
Pain all over the body in last month 11.51 1 0 0 0 1 RNF123
Diabetes (self-reported) 14.92 1 0 0 0 1 RNF123
Medication: Ramipril 7.05 1 0 0 0 1 RNF123
Fluid intelligence score 26.48 1 1 3 0 1 RNF123
Illnesses of siblings 6.07 1 0 0 0 1 RNF123
Neuroticism score 12.28 1 1 3 0 1 RNF123
Weight 19.76 1 1 3 0 1 RNF123
Impedance of arm (right) 23.66 1 1 3 0 1 RNF123
Arm fat percentage (right) 17.76 1 1 3 0 1 RNF123
Trunk fat-free mass 9.06 1 1 3 0 1 RNF123
Hip circumference 12.87 1 1 3 0 1 RNF123
Alcohol intake versus 10 years previously 15.02 1 0 0 0 1 RNF123
Father's age at death 9.45 1 0 0 0 1 RNF123
Number of live births 8.33 1 0 0 0 1 RNF123
Forced expiratory volume in 1-second (FEV1) 8.80 1 1 3 0 1 RNF123
Noisy workplace 7.04 1 0 0 0 1 RNF123
Qualifications: A levels/AS levels or equivalent 38.22 1 1 3 0 1 RNF123
Mouth/teeth dental problems: Dentures 14.18 1 0 0 0 1 RNF123
Asthma 6.53 1 0 0 0 1 RNF123
Forced expiratory volume in 1-second (FEV1), Best measure 8.98 1 1 3 0 1 RNF123
Impedance of arm (left) 23.77 1 1 3 0 1 RNF123
Arm fat mass (right) 24.13 1 1 3 0 1 RNF123
Trunk predicted mass 8.89 1 1 3 0 1 RNF123
Seen doctor (GP) for nerves, anxiety, tension or depression 7.55 1 0 0 0 1 RNF123
Peak expiratory flow (PEF) 5.16 1 0 0 0 1 RNF123
Ever highly irritable/argumentative for 2 days 22.01 1 1 3 0 1 RNF123
Qualifications: O levels/GCSEs or equivalent 10.28 1 0 0 0 1 RNF123
Medication: Paracetamol 9.61 1 0 0 0 1 RNF123
Medication for cholesterol, blood pressure or diabetes 10.08 1 0 0 0 1 RNF123
Medication: Ventolin 100micrograms inhaler 11.15 1 0 0 0 1 RNF123
Chronic bronchitis/emphysema (mother) 15.25 1 0 0 0 1 RNF123
Forced vital capacity (FVC), Best measure 6.67 1 0 0 0 1 RNF123
Body fat percentage 16.31 1 1 3 0 1 RNF123
Leg fat percentage (right) 25.71 1 1 3 0 1 RNF123
Arm fat-free mass (right) 14.76 1 1 3 0 1 RNF123
Exposure to tobacco smoke outside home 14.17 1 0 0 0 1 RNF123
Number of full brothers 12.70 1 0 0 0 1 RNF123
Wheeze or whistling in the chest in last year 22.75 1 1 3 0 1 RNF123
Age at first live birth 30.71 1 1 3 0 1 RNF123
Health satisfaction 14.30 1 0 0 0 1 RNF123
Qualifications: College or University degree 45.01 1 1 3 0 1 RNF123
Medication for pain relief, constipation, heartburn 8.40 1 0 0 0 1 RNF123
Neck or shoulder pain in last month 9.45 1 0 0 0 1 RNF123
Medication: Blood pressure 7.52 1 0 0 0 1 RNF123
Medication: Omeprazole 8.72 1 0 0 0 1 RNF123
Medication: Seretide 50 evohaler 17.64 1 0 0 0 1 RNF123
Whole body fat mass 22.44 1 1 3 0 1 RNF123
Leg fat mass (right) 29.31 1 1 3 0 1 RNF123
Arm predicted mass (right) 15.73 1 1 3 0 1 RNF123
Alcohol intake frequency. 6.74 1 0 0 0 1 RNF123
Comparative height size at age 10 1.83 1 0 0 0 1 RNF123
Number of full sisters 8.62 1 0 0 0 1 RNF123
Overall health rating 30.84 1 1 3 0 1 RNF123
Chest pain or discomfort 9.50 1 0 0 0 1 RNF123
Had major operations 9.41 1 0 0 0 1 RNF123
Age at last live birth 31.45 1 1 3 0 1 RNF123
Leg pain on walking 11.47 1 0 0 0 1 RNF123
Knee pain experienced in last month 9.24 1 0 0 0 1 RNF123
Whole body fat-free mass 10.49 1 1 3 0 1 RNF123
Leg fat-free mass (right) 8.80 1 1 3 0 1 RNF123
Arm fat percentage (left) 17.80 1 1 3 0 1 RNF123
Average weekly red wine intake 7.64 1 0 0 0 1 RNF123
Mood swings 20.14 1 1 3 0 1 RNF123
Loneliness, isolation 11.15 1 0 0 0 1 RNF123
Long-standing illness, disability or infirmity 8.76 1 0 0 0 1 RNF123
Ever had bowel cancer screening 11.12 1 0 0 0 1 RNF123
Diabetes diagnosed by doctor 10.58 1 0 0 0 1 RNF123
Qualifications: nursing, teaching 10.61 1 0 0 0 1 RNF123
Asthma (self-reported) 6.67 1 0 0 0 1 RNF123
Forced expiratory volume in 1-second (FEV1), predicted percentage 9.14 1 0 0 0 1 RNF123
Whole body water mass 10.88 1 1 3 0 1 RNF123
Leg predicted mass (right) 8.61 1 1 3 0 1 RNF123
Arm fat mass (left) 24.10 1 1 3 0 1 RNF123
Number of self-reported non-cancer illnesses 7.61 1 0 0 0 1 RNF123
Miserableness 30.51 1 1 3 0 1 RNF123
Guilty feelings 12.33 1 0 0 0 1 RNF123
Mother's age at death 8.58 1 0 0 0 1 RNF123
Financial situation satisfaction 14.75 1 0 0 0 1 RNF123
Medication: Paracetamol 10.04 1 0 0 0 1 RNF123
Basal metabolic rate 13.31 1 1 3 0 1 RNF123
Leg fat percentage (left) 24.95 1 1 3 0 1 RNF123
Arm fat-free mass (left) 16.28 1 1 3 0 1 RNF123
Number of operations (self-reported) 11.70 1 0 0 0 1 RNF123
Average weekly beer plus cider intake 20.40 1 1 3 0 1 RNF123
Age started oral contraceptive pill 12.80 1 0 0 0 1 RNF123
Diastolic blood pressure, automated reading 7.38 1 0 0 0 1 RNF123
Ever depressed for a whole week 11.98 1 0 0 0 1 RNF123
Vascular/heart problems diagnosed by doctor 3.52 1 0 0 0 1 RNF123
Pain experienced in last month 14.02 1 0 0 0 1 RNF123
Basal cell carcinoma (self-reported) 7.72 1 0 0 0 1 RNF123
Impedance of whole body 18.94 1 1 3 0 1 RNF123
Leg fat mass (left) 29.00 1 1 3 0 1 RNF123
Arm predicted mass (left) 16.33 1 1 3 0 1 RNF123

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.17
GTEx Adipose Visceral Omentum 0 0.0000 1.17
GTEx Adrenal Gland 0 0.0000 1.07
GTEx Artery Aorta 0 0.0000 1.10
GTEx Artery Coronary 0 0.0000 1.18
GTEx Artery Tibial 1 0.0266 1.11
GTEx Brain Caudate basal ganglia 1 0.1087 1.19
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.11
GTEx Brain Cerebellum 1 0.0505 1.14
GTEx Brain Cortex 0 0.0000 1.21
GTEx Brain Frontal Cortex BA9 1 0.1082 1.23
GTEx Brain Hippocampus 0 0.0000 1.19
GTEx Brain Hypothalamus 0 0.0000 1.15
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.11
GTEx Brain Putamen basal ganglia 0 0.0000 1.23
GTEx Breast Mammary Tissue 1 0.0507 1.16
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.20
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.14
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.13
GTEx Cells Transformed fibroblasts 0 0.0000 1.12
GTEx Colon Sigmoid 1 0.0684 1.18
GTEx Colon Transverse 0 0.0000 1.19
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.15
GTEx Esophagus Mucosa 0 0.0000 1.14
GTEx Esophagus Muscularis 0 0.0000 1.18
GTEx Heart Atrial Appendage 0 0.0000 1.13
GTEx Heart Left Ventricle 0 0.0000 1.16
GTEx Liver 0 0.0000 1.12
GTEx Lung 0 0.0000 1.13
GTEx Muscle Skeletal 0 0.0000 1.14
GTEx Nerve Tibial 0 0.0000 1.13
GTEx Ovary 0 0.0000 1.13
GTEx Pancreas 0 0.0000 1.13
GTEx Pituitary 0 0.0000 1.13
GTEx Prostate 0 0.0000 1.11
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.17
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.18
GTEx Small Intestine Terminal Ileum 0 0.0000 1.28
GTEx Spleen 0 0.0000 1.12
GTEx Stomach 1 0.0688 1.15
GTEx Testis 0 0.0000 1.10
GTEx Thyroid 1 0.0250 1.17
GTEx Uterus 0 0.0000 1.17
GTEx Vagina 0 0.0000 1.18
GTEx Whole Blood 0 0.0000 1.10
METSIM Adipose 1 0.0217 1.09
NTR Blood 0 0.0000 1.11
ROSMAP Brain Pre-frontal Cortex 1 0.0228 1.16
YFS Blood 0 0.0000 1.10
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.08
TCGA Breast Tumor 0 0.0000 1.15
TCGA Breast Normal 1 0.0238 1.09
TCGA Ovarian Tumor 0 0.0000 1.06
TCGA Prostate Tumor 1 0.0289 1.13