Hub : Traits :

Diabetes (father)

9 significantly associated models · 7 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 42767044 44157441 1 1 1.0e-07 1.0e-08 1.4e-02 82 AC010883.5
2 6 19703618 21930988 2 2 3.2e-07 2.3e-10 1.2e-04 63 CDKAL1 E2F3
3 10 92987510 95128815 2 1 1.3e-11 1.8e-11 1.8e-01 96 EIF2S2P3
4 10 113511441 115622375 2 1 1.6e-26 2.8e-62 9.7e-38 41 TCF7L2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 4.76 2 1 3.0 0.00 1.0e+00 AC010883.5 CDKAL1
Irritable Bowel Disease (IBD) 4.52 2 1 3.0 0.00 1.0e+00 AC010883.5 EIF2S2P3
Ulcerative Colitis (UC) 2.07 1 0 0.0 0.00 1.0e+00 AC010883.5
Verbal and Numeric Reasoning (VNR) 2.10 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Breast Cancer 7.49 2 2 6.1 0.00 1.0e+00 CDKAL1 TCF7L2
Body Mass Index (BMI) (2010) 1.94 1 0 0.0 0.00 1.0e+00 TCF7L2
Crohns Disease (2012) 3.17 2 0 0.0 0.00 1.0e+00 AC010883.5 CDKAL1
Fasting Glucose 6.98 2 0 0.0 0.00 1.0e+00 E2F3 TCF7L2
HbA1C 6.21 2 0 0.0 0.00 1.0e+00 E2F3 EIF2S2P3
Type 2 Diabetes (T2D) 21.27 3 2 6.1 0.00 1.0e+00 AC010883.5 EIF2S2P3 TCF7L2
Ulcerative Colitis 2.72 1 0 0.0 0.00 1.0e+00 AC010883.5
Blood Eosinophil Count 3.16 2 2 6.1 0.00 1.0e+00 AC010883.5 EIF2S2P3
Blood Platelet Count 5.60 4 2 6.1 -0.39 6.1e-01 AC010883.5 CDKAL1 EIF2S2P3 TCF7L2
Blood Red Count 0.55 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Heel T-Score 2.25 2 1 3.0 0.00 1.0e+00 AC010883.5 TCF7L2
BMI 1.62 1 1 3.0 0.00 1.0e+00 TCF7L2
Height 0.58 3 1 3.0 0.00 1.0e+00 AC010883.5 CDKAL1 TCF7L2
Waist Hip Ratio (WHR) 7.63 5 3 9.1 -0.79 1.1e-01 AC010883.5 CDKAL1 E2F3 EIF2S2P3 TCF7L2
Systolic Blood Pressure 1.90 2 1 3.0 0.00 1.0e+00 CDKAL1 TCF7L2
Allergy or Eczema 2.22 1 0 0.0 0.00 1.0e+00 AC010883.5
Cardiovascular Disease 1.32 1 0 0.0 0.00 1.0e+00 CDKAL1
Hypothyroidism (self reported) 1.63 1 0 0.0 0.00 1.0e+00 AC010883.5
Respiratory disease 1.94 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Type 2 Diabetes (T2D) 56.91 5 5 15.2 -1.00 3.5e-04 AC010883.5 CDKAL1 E2F3 EIF2S2P3 TCF7L2
Lung FEV1/FVC ratio 2.39 1 1 3.0 0.00 1.0e+00 AC010883.5
Neuroticism 1.56 1 0 0.0 0.00 1.0e+00 AC010883.5
Chronotype (morning person) 1.81 1 0 0.0 0.00 1.0e+00 E2F3
Hair Pigment 0.98 3 2 6.1 0.00 1.0e+00 AC010883.5 CDKAL1 E2F3
Hand grip strength (left) 1.61 1 0 0.0 0.00 1.0e+00 AC010883.5
Number of treatments/medications taken 2.65 2 0 0.0 0.00 1.0e+00 CDKAL1 E2F3
Relative age of first facial hair 2.88 2 0 0.0 0.00 1.0e+00 CDKAL1 E2F3
Ever had hysterectomy (womb removed) 2.60 1 0 0.0 0.00 1.0e+00 AC010883.5
Eye problems/disorders: Diabetes related eye disease 7.82 2 0 0.0 0.00 1.0e+00 EIF2S2P3 TCF7L2
Medication: Metformin 31.89 5 3 9.1 0.97 5.9e-03 AC010883.5 CDKAL1 E2F3 EIF2S2P3 TCF7L2
Diabetes (mother) 26.09 5 3 9.1 1.00 3.7e-04 AC010883.5 CDKAL1 E2F3 EIF2S2P3 TCF7L2
Impedance of leg (right) 2.61 4 1 3.0 0.53 4.7e-01 AC010883.5 CDKAL1 E2F3 TCF7L2
Leg fat-free mass (left) 0.75 1 0 0.0 0.00 1.0e+00 TCF7L2
Trunk fat percentage 1.96 4 0 0.0 0.06 9.4e-01 AC010883.5 CDKAL1 E2F3 TCF7L2
Hand grip strength (right) 2.06 1 0 0.0 0.00 1.0e+00 AC010883.5
Maternal smoking around birth 2.02 1 0 0.0 0.00 1.0e+00 AC010883.5
Fed-up feelings 2.38 1 0 0.0 0.00 1.0e+00 AC010883.5
Taking other prescription medications 1.69 1 0 0.0 0.00 1.0e+00 CDKAL1
Age when periods started (menarche) 2.12 2 0 0.0 0.00 1.0e+00 AC010883.5 E2F3
Heel bone mineral density (BMD) T-score, automated (left) 2.11 2 0 0.0 0.00 1.0e+00 AC010883.5 TCF7L2
High blood pressure 1.72 2 0 0.0 0.00 1.0e+00 CDKAL1 E2F3
Hayfever, allergic rhinitis or eczema 2.30 1 0 0.0 0.00 1.0e+00 AC010883.5
Sitting height 0.49 1 0 0.0 0.00 1.0e+00 CDKAL1
Body mass index (BMI) 1.60 1 1 3.0 0.00 1.0e+00 TCF7L2
Impedance of leg (left) 2.71 3 1 3.0 0.00 1.0e+00 AC010883.5 CDKAL1 E2F3
Leg predicted mass (left) 0.79 1 0 0.0 0.00 1.0e+00 TCF7L2
Trunk fat mass 1.45 2 0 0.0 0.00 1.0e+00 AC010883.5 TCF7L2
Waist circumference 1.36 1 0 0.0 0.00 1.0e+00 TCF7L2
Past tobacco smoking 1.76 1 0 0.0 0.00 1.0e+00 E2F3
Heel bone mineral density (BMD) T-score, automated (right) 2.31 1 0 0.0 0.00 1.0e+00 AC010883.5
Heart attack 3.26 1 0 0.0 0.00 1.0e+00 AC010883.5
Allergy 1.99 1 0 0.0 0.00 1.0e+00 AC010883.5
Diabetes (self-reported) 35.63 5 3 9.1 0.97 5.2e-03 AC010883.5 CDKAL1 E2F3 EIF2S2P3 TCF7L2
Medication: Ramipril 2.40 1 0 0.0 0.00 1.0e+00 CDKAL1
Medication: Simvastatin 3.00 1 0 0.0 0.00 1.0e+00 TCF7L2
Neuroticism score 2.48 1 0 0.0 0.00 1.0e+00 AC010883.5
Weight 0.94 1 0 0.0 0.00 1.0e+00 TCF7L2
Impedance of arm (right) 2.06 3 0 0.0 0.00 1.0e+00 AC010883.5 E2F3 TCF7L2
Arm fat percentage (right) 1.68 1 0 0.0 0.00 1.0e+00 TCF7L2
Trunk fat-free mass 0.96 2 0 0.0 0.00 1.0e+00 CDKAL1 E2F3
Hip circumference 2.95 1 1 3.0 0.00 1.0e+00 TCF7L2
Worrier / anxious feelings 1.86 1 0 0.0 0.00 1.0e+00 TCF7L2
Asthma 3.05 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Medication: Cholesterol lowering 2.79 1 0 0.0 0.00 1.0e+00 TCF7L2
Impedance of arm (left) 2.30 3 0 0.0 0.00 1.0e+00 AC010883.5 E2F3 TCF7L2
Arm fat mass (right) 1.39 1 1 3.0 0.00 1.0e+00 TCF7L2
Trunk predicted mass 1.01 2 0 0.0 0.00 1.0e+00 CDKAL1 E2F3
Standing height 0.47 1 0 0.0 0.00 1.0e+00 AC010883.5
Hair/balding pattern: Pattern 4 4.93 2 1 3.0 0.00 1.0e+00 AC010883.5 CDKAL1
Peak expiratory flow (PEF) 2.51 1 1 3.0 0.00 1.0e+00 AC010883.5
Medication: Paracetamol 2.79 2 0 0.0 0.00 1.0e+00 AC010883.5 CDKAL1
Medication for cholesterol, blood pressure or diabetes 1.39 1 0 0.0 0.00 1.0e+00 TCF7L2
Hypothyroidism/myxoedema (self-reported) 1.21 1 0 0.0 0.00 1.0e+00 AC010883.5
Birth weight 8.50 5 1 3.0 -0.29 6.4e-01 AC010883.5 CDKAL1 E2F3 EIF2S2P3 TCF7L2
Body fat percentage 2.47 4 0 0.0 -0.05 9.5e-01 AC010883.5 CDKAL1 E2F3 TCF7L2
Leg fat percentage (right) 2.81 2 1 3.0 0.00 1.0e+00 CDKAL1 TCF7L2
Arm fat-free mass (right) 0.78 1 0 0.0 0.00 1.0e+00 TCF7L2
Worry too long after embarrassment 2.51 2 0 0.0 0.00 1.0e+00 CDKAL1 E2F3
Age at first live birth 1.30 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Medication for pain relief, constipation, heartburn 2.18 1 0 0.0 0.00 1.0e+00 CDKAL1
Neck or shoulder pain in last month 1.47 1 0 0.0 0.00 1.0e+00 AC010883.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.52 1 0 0.0 0.00 1.0e+00 TCF7L2
Whole body fat mass 1.73 1 0 0.0 0.00 1.0e+00 TCF7L2
Leg fat mass (right) 1.99 1 1 3.0 0.00 1.0e+00 TCF7L2
Arm predicted mass (right) 0.80 1 0 0.0 0.00 1.0e+00 TCF7L2
Pulse rate, automated reading 2.76 3 0 0.0 0.00 1.0e+00 AC010883.5 EIF2S2P3 TCF7L2
Comparative height size at age 10 1.72 2 1 3.0 0.00 1.0e+00 AC010883.5 EIF2S2P3
Overall health rating 1.22 1 0 0.0 0.00 1.0e+00 CDKAL1
Age at last live birth 2.87 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Hypertension (Self-reported) 1.62 2 0 0.0 0.00 1.0e+00 CDKAL1 E2F3
Illnesses of siblings: Diabetes 15.00 4 1 3.0 1.00 9.7e-05 AC010883.5 CDKAL1 EIF2S2P3 TCF7L2
Smoking status: Previous 2.20 1 0 0.0 0.00 1.0e+00 E2F3
Whole body fat-free mass 0.90 2 0 0.0 0.00 1.0e+00 CDKAL1 TCF7L2
Leg fat-free mass (right) 0.86 2 0 0.0 0.00 1.0e+00 CDKAL1 TCF7L2
Arm fat percentage (left) 1.80 1 0 0.0 0.00 1.0e+00 TCF7L2
Mood swings 1.72 1 0 0.0 0.00 1.0e+00 AC010883.5
Diabetes diagnosed by doctor 42.78 5 3 9.1 0.98 4.4e-03 AC010883.5 CDKAL1 E2F3 EIF2S2P3 TCF7L2
Ever had stillbirth, spontaneous miscarriage or termination 2.02 1 0 0.0 0.00 1.0e+00 TCF7L2
Qualifications: nursing, teaching 2.39 1 0 0.0 0.00 1.0e+00 TCF7L2
Breast cancer (self-reported) 2.48 1 0 0.0 0.00 1.0e+00 TCF7L2
Asthma (self-reported) 2.83 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Medication: Aspirin 2.25 1 0 0.0 0.00 1.0e+00 TCF7L2
Medication: Gliclazide 17.41 4 1 3.0 0.99 1.3e-02 AC010883.5 E2F3 EIF2S2P3 TCF7L2
Illnesses of father: None of the above (group 1) 2.96 1 0 0.0 0.00 1.0e+00 EIF2S2P3
Whole body water mass 0.89 2 0 0.0 0.00 1.0e+00 CDKAL1 TCF7L2
Leg predicted mass (right) 0.86 2 0 0.0 0.00 1.0e+00 CDKAL1 TCF7L2
Arm fat mass (left) 1.33 1 0 0.0 0.00 1.0e+00 TCF7L2
Average weekly champagne plus white wine intake 2.33 1 0 0.0 0.00 1.0e+00 TCF7L2
High cholesterol (Self-reported) 1.74 1 0 0.0 0.00 1.0e+00 TCF7L2
Medication: Atorvastatin 3.59 1 0 0.0 0.00 1.0e+00 TCF7L2
Ever smoked 1.52 1 0 0.0 0.00 1.0e+00 E2F3
Basal metabolic rate 0.81 1 0 0.0 0.00 1.0e+00 TCF7L2
Leg fat percentage (left) 2.78 2 1 3.0 0.00 1.0e+00 AC010883.5 TCF7L2
Arm fat-free mass (left) 0.87 1 0 0.0 0.00 1.0e+00 TCF7L2
Irritability 2.76 1 0 0.0 0.00 1.0e+00 AC010883.5
Diastolic blood pressure, automated reading 1.18 1 0 0.0 0.00 1.0e+00 TCF7L2
Ever depressed for a whole week 2.36 1 0 0.0 0.00 1.0e+00 E2F3
Myopia 1.70 1 0 0.0 0.00 1.0e+00 TCF7L2
Vascular/heart problems diagnosed by doctor 2.02 2 0 0.0 0.00 1.0e+00 CDKAL1 E2F3
Cholesterol lowering medication 4.16 1 0 0.0 0.00 1.0e+00 TCF7L2
Heart attack/myocardial infarction (self-reported) 3.10 1 0 0.0 0.00 1.0e+00 AC010883.5
Impedance of whole body 2.80 4 1 3.0 0.52 4.8e-01 AC010883.5 CDKAL1 E2F3 TCF7L2
Leg fat mass (left) 2.03 1 1 3.0 0.00 1.0e+00 TCF7L2
Arm predicted mass (left) 0.80 1 0 0.0 0.00 1.0e+00 TCF7L2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.23
GTEx Adipose Visceral Omentum 0 0.0000 1.29
GTEx Adrenal Gland 0 0.0000 1.30
GTEx Artery Aorta 1 0.0336 1.34
GTEx Artery Coronary 0 0.0000 1.25
GTEx Artery Tibial 0 0.0000 1.26
GTEx Brain Caudate basal ganglia 0 0.0000 1.20
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.28
GTEx Brain Cerebellum 0 0.0000 1.20
GTEx Brain Cortex 0 0.0000 1.29
GTEx Brain Frontal Cortex BA9 0 0.0000 1.30
GTEx Brain Hippocampus 0 0.0000 1.22
GTEx Brain Hypothalamus 0 0.0000 1.14
GTEx Brain Nucleus accumbens basal ganglia 1 0.1156 1.24
GTEx Brain Putamen basal ganglia 0 0.0000 1.23
GTEx Breast Mammary Tissue 0 0.0000 1.25
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.22
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.28
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.26
GTEx Cells Transformed fibroblasts 1 0.0238 1.28
GTEx Colon Sigmoid 0 0.0000 1.22
GTEx Colon Transverse 0 0.0000 1.30
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.17
GTEx Esophagus Mucosa 0 0.0000 1.25
GTEx Esophagus Muscularis 1 0.0309 1.28
GTEx Heart Atrial Appendage 0 0.0000 1.29
GTEx Heart Left Ventricle 0 0.0000 1.31
GTEx Liver 0 0.0000 1.21
GTEx Lung 0 0.0000 1.27
GTEx Muscle Skeletal 0 0.0000 1.29
GTEx Nerve Tibial 0 0.0000 1.24
GTEx Ovary 0 0.0000 1.29
GTEx Pancreas 0 0.0000 1.24
GTEx Pituitary 0 0.0000 1.26
GTEx Prostate 0 0.0000 1.37
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.30
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.29
GTEx Small Intestine Terminal Ileum 0 0.0000 1.37
GTEx Spleen 0 0.0000 1.24
GTEx Stomach 0 0.0000 1.22
GTEx Testis 0 0.0000 1.25
GTEx Thyroid 3 0.0750 1.27
GTEx Uterus 0 0.0000 1.30
GTEx Vagina 0 0.0000 1.27
GTEx Whole Blood 0 0.0000 1.22
METSIM Adipose 0 0.0000 1.15
NTR Blood 1 0.0416 1.30
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.26
YFS Blood 0 0.0000 1.19
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.25
TCGA Breast Tumor 0 0.0000 1.31
TCGA Breast Normal 0 0.0000 1.20
TCGA Ovarian Tumor 0 0.0000 1.18
TCGA Prostate Tumor 1 0.0289 1.25