Hub : Traits :

Body Mass Index (BMI) (2010)

248 significantly associated models · 46 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 71163715 73435171 1 1 1.3e-13 1.2e-14 1.8e-03 84 NEGR1
2 2 24348096 25837917 1 1 1.3e-07 1.8e-07 3.6e-01 97 ADCY3
3 3 140514022 142017527 1 1 3.0e-07 1.1e-06 6.3e-02 85 RASA2
4 5 74280980 75704085 1 1 3.4e-07 1.9e-07 1.9e-01 94 POC5
5 12 49569311 50991370 1 1 2.2e-08 4.0e-11 1.3e-04 67 FAIM2
6 13 27315078 28717392 2 1 1.3e-07 3.0e-07 5.6e-02 86 MTIF3
7 15 67138238 68789191 1 1 2.6e-11 1.2e-10 1.3e-01 94 MAP2K5
8 16 19022448 20596558 3 1 9.8e-11 4.6e-11 1.0e+00 100 GPRC5B
9 16 27655848 29595483 22 1 4.5e-12 1.7e-10 3.8e-01 98 EIF3C
10 16 52828325 54846383 2 2 1.0e-17 3.1e-62 7.9e-37 42 AKTIP FTO
11 18 57349900 58729694 1 1 2.6e-07 2.1e-22 1.1e-16 28 MC4R

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 4.19 2 2 6.1 0.00 1.0e+00 ADCY3 EIF3C
Irritable Bowel Disease (IBD) 3.61 2 2 6.1 0.00 1.0e+00 ADCY3 EIF3C
Ulcerative Colitis (UC) 1.57 1 0 0.0 0.00 1.0e+00 EIF3C
Major Depression (MDD) 3.52 1 1 3.0 0.00 1.0e+00 NEGR1
Reaction Time 1.10 1 0 0.0 0.00 1.0e+00 ADCY3
Verbal and Numeric Reasoning (VNR) 5.51 3 2 6.1 0.00 1.0e+00 ADCY3 EIF3C NEGR1
Breast Cancer 4.70 3 1 3.0 0.00 1.0e+00 ADCY3 AKTIP FTO
Crohns Disease (2012) 2.05 1 0 0.0 0.00 1.0e+00 ADCY3
LDL Cholesterol 5.89 1 1 3.0 0.00 1.0e+00 POC5
Type 2 Diabetes (T2D) 3.67 1 0 0.0 0.00 1.0e+00 MC4R
Blood Eosinophil Count 0.62 1 0 0.0 0.00 1.0e+00 ADCY3
Blood Platelet Count 1.10 2 2 6.1 0.00 1.0e+00 GPRC5B POC5
Blood Red Count 1.03 2 1 3.0 0.00 1.0e+00 EIF3C RASA2
Blood White Count 0.83 3 0 0.0 0.00 1.0e+00 ADCY3 FTO MAP2K5
Heel T-Score 1.23 4 2 6.1 1.00 2.0e-03 FAIM2 GPRC5B NEGR1 POC5
BMI 29.68 12 12 36.4 0.96 1.1e-06 ADCY3 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5 RASA2
Height 2.83 6 3 9.1 -0.07 9.0e-01 ADCY3 EIF3C FAIM2 GPRC5B MC4R MTIF3
Waist Hip Ratio (WHR) 0.87 1 0 0.0 0.00 1.0e+00 FTO
Systolic Blood Pressure 1.83 1 1 3.0 0.00 1.0e+00 ADCY3
Smoking Status 1.63 1 0 0.0 0.00 1.0e+00 ADCY3
Allergy or Eczema 2.04 2 1 3.0 0.00 1.0e+00 EIF3C NEGR1
Cardiovascular Disease 2.72 3 1 3.0 0.00 1.0e+00 FTO NEGR1 POC5
Type 2 Diabetes (T2D) 3.99 2 0 0.0 0.00 1.0e+00 AKTIP POC5
Lung FEV1/FVC ratio 1.89 2 2 6.1 0.00 1.0e+00 ADCY3 NEGR1
Lung FVC 1.45 2 1 3.0 0.00 1.0e+00 EIF3C MAP2K5
Neuroticism 2.58 2 0 0.0 0.00 1.0e+00 MAP2K5 MC4R
Chronotype (morning person) 2.99 3 1 3.0 0.00 1.0e+00 ADCY3 AKTIP FTO
Hair Pigment 0.13 1 0 0.0 0.00 1.0e+00 ADCY3
Tanning 0.32 1 1 3.0 0.00 1.0e+00 ADCY3
Hand grip strength (left) 3.51 2 2 6.1 0.00 1.0e+00 ADCY3 GPRC5B
Number of treatments/medications taken 1.69 1 0 0.0 0.00 1.0e+00 NEGR1
Relative age of first facial hair 2.67 2 0 0.0 0.00 1.0e+00 FTO NEGR1
Other serious medical condition/disability diagnosed by doctor 1.37 1 0 0.0 0.00 1.0e+00 NEGR1
Impedance of leg (right) 13.79 12 9 27.3 0.93 1.1e-05 ADCY3 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5 RASA2
Leg fat-free mass (left) 15.50 11 10 30.3 -0.94 1.9e-05 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5 RASA2
Trunk fat percentage 14.67 10 9 27.3 -0.95 3.5e-05 ADCY3 AKTIP EIF3C FAIM2 FTO MAP2K5 MC4R MTIF3 NEGR1 POC5
Hand grip strength (right) 3.21 3 1 3.0 0.00 1.0e+00 ADCY3 EIF3C GPRC5B
Townsend deprivation index at recruitment 1.72 1 0 0.0 0.00 1.0e+00 MAP2K5
Taking other prescription medications 1.36 1 0 0.0 0.00 1.0e+00 NEGR1
Age when periods started (menarche) 8.58 7 4 12.1 0.98 6.3e-05 ADCY3 AKTIP FAIM2 FTO GPRC5B MAP2K5 NEGR1
High blood pressure 2.07 1 0 0.0 0.00 1.0e+00 NEGR1
Hayfever, allergic rhinitis or eczema 1.57 1 0 0.0 0.00 1.0e+00 NEGR1
Multivitamins +/- minerals 2.55 1 0 0.0 0.00 1.0e+00 NEGR1
Sitting height 3.43 3 1 3.0 0.00 1.0e+00 ADCY3 MTIF3 POC5
Body mass index (BMI) 23.84 12 11 33.3 -0.95 2.1e-06 ADCY3 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5 RASA2
Impedance of leg (left) 14.21 11 8 24.2 0.93 3.6e-05 ADCY3 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5
Leg predicted mass (left) 15.45 10 10 30.3 -0.94 4.2e-05 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5
Trunk fat mass 17.53 12 10 30.3 -0.95 2.0e-06 ADCY3 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5 RASA2
Waist circumference 20.16 12 10 30.3 -0.96 1.3e-06 ADCY3 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5 RASA2
Past tobacco smoking 2.65 2 0 0.0 0.00 1.0e+00 ADCY3 MAP2K5
Alcohol usually taken with meals 3.24 1 0 0.0 0.00 1.0e+00 NEGR1
Forced vital capacity (FVC) 2.12 1 1 3.0 0.00 1.0e+00 ADCY3
Qualifications: None of the above 3.32 2 2 6.1 0.00 1.0e+00 EIF3C NEGR1
Allergy 1.15 1 0 0.0 0.00 1.0e+00 NEGR1
Diabetes (self-reported) 3.03 1 0 0.0 0.00 1.0e+00 POC5
Fluid intelligence score 4.15 2 2 6.1 0.00 1.0e+00 EIF3C NEGR1
Neuroticism score 2.17 1 0 0.0 0.00 1.0e+00 MC4R
Weight 19.21 12 12 36.4 -0.95 1.9e-06 ADCY3 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5 RASA2
Impedance of arm (right) 8.89 8 6 18.2 0.94 6.3e-04 AKTIP FAIM2 FTO GPRC5B MAP2K5 MC4R NEGR1 POC5
Arm fat percentage (right) 20.53 12 10 30.3 -0.93 8.9e-06 ADCY3 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5 RASA2
Trunk fat-free mass 9.43 9 7 21.2 -0.92 4.5e-04 AKTIP EIF3C FAIM2 FTO GPRC5B MC4R MTIF3 NEGR1 POC5
Hip circumference 19.64 12 11 33.3 -0.95 1.9e-06 ADCY3 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5 RASA2
Alcohol intake versus 10 years previously 2.04 1 0 0.0 0.00 1.0e+00 NEGR1
Worrier / anxious feelings 2.78 1 0 0.0 0.00 1.0e+00 MC4R
Forced expiratory volume in 1-second (FEV1) 1.49 1 1 3.0 0.00 1.0e+00 ADCY3
Pulse rate 2.20 1 0 0.0 0.00 1.0e+00 POC5
Qualifications: A levels/AS levels or equivalent 1.89 1 1 3.0 0.00 1.0e+00 NEGR1
Serious illness, injury or assault of a close relative in last 2 years 2.08 1 0 0.0 0.00 1.0e+00 EIF3C
Mouth/teeth dental problems: Dentures 2.61 1 0 0.0 0.00 1.0e+00 ADCY3
Medication: Cholesterol lowering 2.93 1 0 0.0 0.00 1.0e+00 POC5
Forced expiratory volume in 1-second (FEV1), Best measure 1.18 1 1 3.0 0.00 1.0e+00 ADCY3
Impedance of arm (left) 9.03 8 6 18.2 0.92 1.1e-03 AKTIP FAIM2 FTO GPRC5B MAP2K5 MC4R NEGR1 POC5
Arm fat mass (right) 22.52 12 11 33.3 -0.96 9.6e-07 ADCY3 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5 RASA2
Trunk predicted mass 9.48 9 7 21.2 -0.92 4.5e-04 AKTIP EIF3C FAIM2 FTO GPRC5B MC4R MTIF3 NEGR1 POC5
Standing height 2.93 3 2 6.1 0.00 1.0e+00 ADCY3 EIF3C MC4R
Seen doctor (GP) for nerves, anxiety, tension or depression 4.74 2 1 3.0 0.00 1.0e+00 MAP2K5 NEGR1
Peak expiratory flow (PEF) 0.88 1 0 0.0 0.00 1.0e+00 ADCY3
Headache pain in last month 2.28 1 0 0.0 0.00 1.0e+00 POC5
Medication for cholesterol, blood pressure or diabetes 3.36 1 0 0.0 0.00 1.0e+00 AKTIP
Forced vital capacity (FVC), Best measure 1.80 1 1 3.0 0.00 1.0e+00 ADCY3
Body fat percentage 16.51 10 9 27.3 -0.95 3.0e-05 ADCY3 AKTIP EIF3C FAIM2 FTO MAP2K5 MC4R MTIF3 NEGR1 POC5
Leg fat percentage (right) 15.77 10 9 27.3 -0.94 4.4e-05 ADCY3 AKTIP EIF3C FAIM2 FTO MAP2K5 MC4R NEGR1 POC5 RASA2
Arm fat-free mass (right) 11.76 10 8 24.2 -0.92 1.6e-04 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5
Comparative body size at age 10 49.73 12 11 33.3 -0.93 1.1e-05 ADCY3 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5 RASA2
Worry too long after embarrassment 3.00 1 0 0.0 0.00 1.0e+00 POC5
Qualifications: College or University degree 4.27 2 2 6.1 0.00 1.0e+00 EIF3C NEGR1
Migraine (self-reported) 1.69 1 0 0.0 0.00 1.0e+00 POC5
Whole body fat mass 19.76 12 11 33.3 -0.96 1.2e-06 ADCY3 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5 RASA2
Leg fat mass (right) 21.41 12 10 30.3 -0.95 1.7e-06 ADCY3 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5 RASA2
Arm predicted mass (right) 11.75 10 8 24.2 -0.92 1.6e-04 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5
Pulse rate, automated reading 2.17 3 1 3.0 0.00 1.0e+00 GPRC5B NEGR1 POC5
Alcohol intake frequency. 5.09 2 1 3.0 0.00 1.0e+00 EIF3C NEGR1
Comparative height size at age 10 3.26 6 3 9.1 -0.51 3.0e-01 ADCY3 EIF3C FAIM2 FTO MTIF3 POC5
Suffer from 'nerves' 4.12 2 1 3.0 0.00 1.0e+00 EIF3C MC4R
Commuting to job workplace: Car/motor vehicle 2.30 1 0 0.0 0.00 1.0e+00 NEGR1
Hypertension (Self-reported) 1.83 1 0 0.0 0.00 1.0e+00 NEGR1
Forced expiratory volume in 1-second (FEV1), predicted 2.03 1 0 0.0 0.00 1.0e+00 ADCY3
Whole body fat-free mass 11.97 10 9 27.3 -0.92 1.3e-04 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5
Leg fat-free mass (right) 14.48 11 10 30.3 -0.94 2.0e-05 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5 RASA2
Arm fat percentage (left) 20.88 12 10 30.3 -0.94 8.0e-06 ADCY3 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5 RASA2
Long-standing illness, disability or infirmity 3.18 1 0 0.0 0.00 1.0e+00 NEGR1
Diabetes diagnosed by doctor 2.84 2 0 0.0 0.00 1.0e+00 AKTIP POC5
Qualifications: nursing, teaching 3.01 1 1 3.0 0.00 1.0e+00 NEGR1
Breast cancer (self-reported) 1.86 1 0 0.0 0.00 1.0e+00 FTO
Whole body water mass 12.03 10 9 27.3 -0.92 1.3e-04 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5
Leg predicted mass (right) 14.55 10 10 30.3 -0.94 4.4e-05 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5
Arm fat mass (left) 22.96 12 11 33.3 -0.96 8.6e-07 ADCY3 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5 RASA2
Number of self-reported non-cancer illnesses 2.33 1 1 3.0 0.00 1.0e+00 NEGR1
Hearing aid user 2.79 1 0 0.0 0.00 1.0e+00 ADCY3
Commuting to job workplace: Public transport 2.18 1 0 0.0 0.00 1.0e+00 NEGR1
High cholesterol (Self-reported) 3.04 1 1 3.0 0.00 1.0e+00 POC5
Medication: Atorvastatin 2.24 1 0 0.0 0.00 1.0e+00 POC5
Basal metabolic rate 13.93 11 9 27.3 -0.93 3.4e-05 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5 RASA2
Leg fat percentage (left) 16.20 10 9 27.3 -0.95 2.3e-05 ADCY3 AKTIP EIF3C FAIM2 FTO MAP2K5 MC4R NEGR1 POC5 RASA2
Arm fat-free mass (left) 12.65 10 9 27.3 -0.92 1.7e-04 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5
Number of operations (self-reported) 1.26 1 0 0.0 0.00 1.0e+00 NEGR1
Average weekly beer plus cider intake 4.49 1 0 0.0 0.00 1.0e+00 NEGR1
Diastolic blood pressure, automated reading 1.60 1 0 0.0 0.00 1.0e+00 MAP2K5
Commuting to job workplace: Cycle 1.20 1 0 0.0 0.00 1.0e+00 NEGR1
Vascular/heart problems diagnosed by doctor 1.88 2 0 0.0 0.00 1.0e+00 MAP2K5 NEGR1
Impedance of whole body 12.92 10 8 24.2 0.93 1.1e-04 ADCY3 AKTIP FAIM2 FTO GPRC5B MAP2K5 MC4R NEGR1 POC5 RASA2
Leg fat mass (left) 21.50 12 10 30.3 -0.95 1.5e-06 ADCY3 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5 RASA2
Arm predicted mass (left) 12.38 10 9 27.3 -0.92 1.6e-04 AKTIP EIF3C FAIM2 FTO GPRC5B MAP2K5 MC4R MTIF3 NEGR1 POC5

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 11 0.3253 1.51
GTEx Adipose Visceral Omentum 4 0.2025 1.53
GTEx Adrenal Gland 3 0.2114 1.31
GTEx Artery Aorta 10 0.3479 1.52
GTEx Artery Coronary 2 0.1733 1.48
GTEx Artery Tibial 10 0.2753 1.51
GTEx Brain Caudate basal ganglia 2 0.2242 1.54
GTEx Brain Cerebellar Hemisphere 1 0.0693 1.56
GTEx Brain Cerebellum 1 0.0521 1.56
GTEx Brain Cortex 4 0.3988 1.59
GTEx Brain Frontal Cortex BA9 1 0.1116 1.49
GTEx Brain Hippocampus 1 0.1972 1.33
GTEx Brain Hypothalamus 1 0.1754 1.49
GTEx Brain Nucleus accumbens basal ganglia 2 0.2367 1.54
GTEx Brain Putamen basal ganglia 1 0.1650 1.49
GTEx Breast Mammary Tissue 8 0.4191 1.48
GTEx Breast Mammary Tissue (Male) 4 0.3445 1.37
GTEx Breast Mammary Tissue (Female) 4 0.2536 1.38
GTEx Cells EBV-transformed lymphocytes 1 0.0725 1.53
GTEx Cells Transformed fibroblasts 8 0.1964 1.45
GTEx Colon Sigmoid 4 0.2815 1.40
GTEx Colon Transverse 6 0.3015 1.51
GTEx Esophagus Gastroesophageal Junction 4 0.2863 1.52
GTEx Esophagus Mucosa 5 0.1555 1.50
GTEx Esophagus Muscularis 10 0.3191 1.54
GTEx Heart Atrial Appendage 4 0.2608 1.46
GTEx Heart Left Ventricle 6 0.4057 1.57
GTEx Liver 3 0.4304 1.59
GTEx Lung 6 0.2160 1.49
GTEx Muscle Skeletal 6 0.2139 1.49
GTEx Nerve Tibial 10 0.2387 1.47
GTEx Ovary 5 0.5669 1.58
GTEx Pancreas 3 0.1886 1.46
GTEx Pituitary 2 0.1832 1.46
GTEx Prostate 2 0.2481 1.44
GTEx Skin Not Sun Exposed Suprapubic 8 0.3340 1.53
GTEx Skin Sun Exposed Lower leg 9 0.2554 1.53
GTEx Small Intestine Terminal Ileum 1 0.2222 1.52
GTEx Spleen 5 0.3634 1.57
GTEx Stomach 5 0.3529 1.65
GTEx Testis 10 0.3267 1.48
GTEx Thyroid 3 0.0777 1.44
GTEx Uterus 1 0.1808 1.45
GTEx Vagina 5 0.8143 1.67
GTEx Whole Blood 7 0.3646 1.55
METSIM Adipose 8 0.1772 1.40
NTR Blood 2 0.0841 1.28
ROSMAP Brain Pre-frontal Cortex 8 0.1876 1.52
YFS Blood 4 0.0878 1.32
CommonMind Brain Pre-frontal Cortex 9 0.1711 1.34
TCGA Breast Tumor 1 0.1321 1.36
TCGA Breast Normal 2 0.0485 1.21
TCGA Ovarian Tumor 4 0.1386 1.29
TCGA Prostate Tumor 1 0.0296 1.34