TWAS hub - CELF4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.053	0.0250	0.00800	0.002	0.017	0.004	NA	0.002	1.8e-01	3.6e-03	9.9e-02	NA	1.5e-01
2	METSIM	Adipose	0.042	0.0171	0.00023	0.035	0.029	0.035	0.032	0.043	5.2e-06	2.7e-05	4.9e-06	1e-05	4.1e-07
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.088	0.0390	0.00850	0.010	0.016	0.022	NA	0.010	8.3e-02	4.0e-02	2.0e-02	NA	8.0e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Neuroticism (Nagel 2018)	10.2	24.1	36.9	6.1	1.1	5.8
Neuroticism score	9.1	19.1	29.6	5.1	1.2	5.4
Frequency of depressed mood in last 2 weeks	8.9	12.5	28.5	5.3	0.9	2.8
Fed-up feelings	8.9	16.1	34.4	3.6	-0.9	5.9
Neuroticism	8.7	20.9	34.8	5.2	0.9	5.9
Sensitivity / hurt feelings	8.7	14.9	21.8	3.8	2.8	4.7
Alcohol usually taken with meals	8.1	13.0	28.6	-2.2	2.4	-5.3
Depressed Affect (Nagel 2018)	7.8	16.3	28.2	4.5	-0.8	5.3
Depression (Nagel 2018)	7.8	11.7	26.8	5.2	0.8	2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	7.0	10.7	21.7	3.1	-0.9	4.7
Mood swings	7.0	12.7	25.6	3.5	-0.7	5.1
Qualifications: College or University degree	6.8	21.6	44.3	-4.4	-1.1	-6.7
Neuroticism (2016)	6.3	9.1	16.4	3.2	1.0	4.1
Worry (Nagel 2018)	6.0	12.7	26.0	5.1	2.0	2.8
Irritability	5.7	9.7	18.5	2.9	-1.5	4.3
Frequency of tenseness / restlessness in last 2 weeks	5.6	8.8	17.6	4.2	1.5	2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	5.5	7.3	18.4	4.3	1.0	1.6
Average weekly beer plus cider intake	5.5	8.0	20.1	1.3	-1.5	4.5
Qualifications: None of the above	5.4	11.7	20.9	3.0	2.3	4.6
Miserableness	5.3	9.1	18.6	2.7	-1.1	4.3
Suffer from ‘nerves’	4.8	7.5	12.8	3.6	2.4	2.0
Age at first live birth	4.7	8.3	22.0	-1.6	0.4	-4.7
Frequency of tiredness / lethargy in last 2 weeks	4.6	7.5	10.8	3.0	1.7	3.3
Tense / ‘highly strung’	4.5	7.4	13.5	3.7	2.4	1.7
Qualifications: nursing, teaching	4.5	6.9	11.0	-3.1	0.1	-3.3
Current tobacco smoking	4.3	7.0	16.9	1.9	0.6	4.1
Worry too long after embarrassment	4.2	7.0	10.4	3.2	0.9	3.1
Guilty feelings	4.2	6.3	10.5	2.7	1.1	3.2
Pack years adult smoking proportion	4.1	6.3	18.4	0.4	-0.5	4.3
Overall health rating	4.0	8.7	11.4	3.4	3.0	2.4
Pack years of smoking	4.0	5.9	17.3	0.4	-0.4	4.2
Nervous feelings	3.7	6.9	17.9	4.2	1.2	1.1
Age at last live birth	3.7	5.4	10.0	-2.5	0.3	-3.2
Qualifications: A levels/AS levels or equivalent	3.6	8.0	12.6	-2.6	-2.1	-3.5
Supplements: Vitamin C	3.6	4.2	7.5	0.6	2.7	-2.2
Average weekly red wine intake	3.5	5.2	10.0	-2.2	-0.8	-3.2
Mean time to correctly identify matches	3.4	6.5	13.9	0.9	2.2	-3.7
Illnesses of siblings: Diabetes	3.4	4.2	7.6	2.2	2.8	0.6
Reason for reducing amount of alcohol drunk: Health precaution	3.2	3.7	8.4	-2.9	0.5	-1.6
Smoking status: Current	3.2	5.1	13.2	1.4	0.2	3.6
Pain experienced in last month	3.2	5.3	9.1	-3.0	-2.0	-1.7
Number of full sisters	3.0	3.7	7.1	2.0	2.7	0.3
Loneliness, isolation	3.0	4.2	9.5	3.1	-1.3	1.2
Reaction Time	2.9	5.6	10.4	0.8	2.4	-3.2
Migraine (self-reported)	2.9	3.6	6.9	-0.7	-1.9	2.6
Maternal smoking around birth	2.8	4.1	10.6	-0.6	-1.1	3.3
Worrier / anxious feelings	2.8	5.2	9.0	2.3	1.2	3.0
Number of full brothers	2.8	3.6	5.7	2.0	2.4	1.0
Taking other prescription medications	2.6	4.0	7.7	2.8	0.2	2.0
Wheeze or whistling in the chest in last year	2.6	4.7	13.0	0.7	-0.7	3.6
Illnesses of siblings	2.5	3.6	8.9	-1.3	-3.0	-0.2
Shortness of breath walking on level ground	2.5	3.0	4.9	1.6	-1.2	2.2
Number of self-reported non-cancer illnesses	2.5	4.4	8.5	2.1	0.3	2.9
Mean Putamen Volume	2.4	2.8	6.5	0.7	2.6	-1.1
Mouth/teeth dental problems	2.4	3.7	6.0	-2.5	0.1	-2.2
Osteoarthritis (self-reported)	2.4	3.1	3.3	1.8	-1.8	1.7
Ever used hormone-replacement therapy (HRT)	2.3	2.9	3.5	-1.8	1.9	1.4
Financial situation satisfaction	2.3	2.8	7.5	2.7	0.2	1.0
Ever unenthusiastic/disinterested for a whole week	2.2	2.7	5.3	1.4	-0.9	2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.8	4.8	1.9	0.4	2.2
Neck or shoulder pain in last month	2.2	3.1	4.4	2.1	0.8	2.1
Ever taken oral contraceptive pill	2.2	2.5	3.7	-1.7	1.9	-0.9
Past tobacco smoking	2.1	3.8	7.8	0.6	2.8	-1.9
Medication: Bendroflumethiazide	2.1	3.2	5.3	1.3	-1.6	2.3
Age at First Birth	2.0	2.9	6.2	1.6	0.2	-2.5
Chronotype (morning person)	2.0	4.6	11.8	-3.4	0.4	-1.4
Medication: Co-codamol	2.0	2.3	5.1	2.3	0.9	1.0
Mouth/teeth dental problems: Dentures	2.0	3.4	9.2	1.0	0.1	3.0
Had major operations	2.0	2.4	5.8	2.4	-0.5	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.4	4.3	1.6	2.1	0.5
Medication: Lisinopril	2.0	2.6	6.2	-2.5	-1.2	0.6
Stomach or abdominal pain in last month	1.9	2.3	5.9	1.0	2.4	-0.2
Pain all over the body in last month	1.9	2.0	3.0	1.7	1.7	0.3
Number of live births	1.9	2.7	6.6	0.7	1.0	2.6
Number of operations (self-reported)	1.9	2.8	3.9	2.0	0.6	2.0
Qualifications: CSEs or equivalent	1.8	2.4	5.9	0.7	2.4	-0.9
Leg fat percentage (right)	1.8	6.4	10.8	3.3	-0.9	2.8
Smoking status: Previous	1.8	2.6	6.1	-1.2	-2.5	0.5
Age started oral contraceptive pill	1.8	2.2	5.7	-1.0	0.4	-2.4
Major Depression (MDD)	1.7	2.1	4.2	1.2	0.8	2.0
Smoking Status	1.7	4.1	8.6	1.4	-1.3	2.9
Diabetes (father)	1.7	2.1	5.0	1.2	2.2	-0.1
Medication: Seretide 50 evohaler	1.7	1.9	3.1	-1.4	1.8	-0.8
Leg fat percentage (left)	1.7	6.2	11.4	3.4	-1.1	2.5
Type 2 Diabetes (T2D) (2018)	1.6	3.0	5.3	-1.8	-0.5	2.3
Happiness	1.6	1.9	3.8	1.9	-0.7	1.2
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	2.7	-1.7	1.2	-1.4
Mineral and other dietary supplements	1.6	2.2	5.7	-0.7	-0.7	2.4
Average weekly champagne plus white wine intake	1.6	2.2	4.6	-1.3	-0.6	-2.1
Prostate Cancer	1.5	2.2	5.5	-0.2	2.4	-0.9
Body Mass Index (BMI) (2010)	1.5	2.1	5.2	0.6	-2.3	0.8
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	2.7	1.4	1.6	-0.1
Number of incorrect matches in round	1.5	2.4	4.8	2.2	1.2	-1.0
Medication: Ibuprofen (e.g. Nurofen)	1.5	2.0	4.1	-1.3	-0.3	2.0
Qualifications: O levels/GCSEs or equivalent	1.5	2.5	5.5	-0.4	-1.3	-2.4
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	5.1	2.3	-0.9	0.2
Body fat percentage	1.5	6.1	11.2	3.4	-1.1	2.4
Family relationship satisfaction	1.5	1.8	3.7	1.9	0.2	1.3
Ever depressed for a whole week	1.5	1.9	5.3	0.4	0.4	2.3
Vitamin and mineral supplements	1.4	1.9	2.5	-1.1	-1.6	1.4
Father’s age at death	1.4	1.9	5.3	-0.6	0.1	-2.3
Ever highly irritable/argumentative for 2 days	1.4	1.7	5.0	0.2	-0.0	2.2
Medication for cholesterol	1.4	2.2	2.8	-1.1	1.6	-1.7
Medication: Gliclazide	1.4	1.6	2.8	1.7	0.1	1.4
Hand grip strength (left)	1.3	3.4	4.8	-2.2	-1.0	-2.1
Ever had hysterectomy (womb removed)	1.3	1.4	3.0	-1.0	0.5	1.7
Trunk fat percentage	1.3	5.1	9.9	3.2	-1.0	2.1
Medication: Ibuprofen	1.3	1.5	4.2	-0.4	0.4	2.1
Commuting to job workplace: Car/motor vehicle	1.3	1.4	2.4	-1.5	-1.0	1.0
Medication: Aspirin	1.3	1.6	2.5	1.3	1.6	0.9
Wears glasses or contact lenses	1.3	1.4	3.9	-2.0	0.4	-0.5
Unable to work because of sickness or disability	1.3	1.7	4.6	0.8	0.1	2.1
Commuting to job workplace: Cycle	1.3	1.6	3.1	1.1	0.7	-1.8
Cholesterol lowering medication	1.3	1.9	4.5	0.7	-2.1	0.9
Hearing difficulty/problems: Yes	1.2	1.8	5.0	-0.1	2.2	0.7
Townsend deprivation index at recruitment	1.2	1.7	5.1	0.3	0.0	2.3
Diverticular disease/diverticulitis (self-reported)	1.2	1.5	2.2	0.6	1.5	1.4
Medication: Lansoprazole	1.2	1.4	2.5	1.2	-0.6	1.6
Illnesses of mother	1.2	1.4	3.5	-0.9	-1.9	0.1
Exposure to tobacco smoke at home	1.2	1.4	3.1	-1.0	-0.0	1.8
Breastfed as a baby	1.2	1.5	3.0	-0.7	1.0	-1.7
Hair/balding pattern: Pattern 4	1.2	3.0	6.1	-0.9	-2.5	1.4
Birth weight of first child	1.2	2.1	3.3	-0.2	1.8	-1.7
Medication for pain relief, constipation, heartburn	1.2	2.0	4.1	-1.1	-0.9	-2.0
Commuting to job workplace: Walk	1.2	1.3	3.4	0.4	1.8	-0.7
Back pain experienced in last month	1.2	1.7	2.1	1.4	1.0	1.5
Commuting to job workplace: Public transport	1.2	1.5	4.3	0.1	0.3	-2.1
Number of treatments/medications taken	1.1	1.9	3.7	1.9	0.3	1.4
Average weekly spirits intake	1.1	1.4	3.3	-0.5	1.8	0.7
Medication for hormone replacement therapy	1.1	1.2	2.4	-0.3	1.6	1.1
Serious illness, injury or assault to yourself	1.1	1.3	2.5	0.5	-1.6	1.1
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.9	0.5	2.0	0.1
Mouth/teeth dental problems: Loose teeth	1.1	1.3	1.7	-1.3	-0.8	1.2
Medication: Omeprazole	1.1	1.3	3.7	0.3	1.9	-0.1
Heart disease (mother)	1.1	1.4	3.1	1.7	1.0	0.2
Chest pain or discomfort	1.1	1.6	1.8	1.3	1.2	1.2
Medication: Aspirin	1.1	1.5	3.0	1.0	1.7	0.7
Supplements: Fish oil (including cod liver oil)	1.1	1.5	4.3	0.4	-0.0	-2.1
High cholesterol (Self-reported)	1.1	2.0	4.0	1.3	-0.7	2.0
Myopia	1.1	1.5	2.4	0.2	-1.5	1.5
Schizophrenia (2018)	1.0	2.1	3.4	1.8	1.6	0.7
Medication: Ramipril	1.0	1.3	3.2	1.8	-0.7	0.5
Falls in the last year	1.0	1.4	3.2	1.8	0.9	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	5.4	-1.9	-0.9	-2.3
Loud music exposure frequency	1.0	1.1	2.1	0.3	1.0	-1.4
Blood clot in the leg (DVT)	1.0	1.3	2.2	1.2	1.5	0.3
Medication: Paracetamol	1.0	1.6	3.7	-0.4	1.9	0.9
Headache pain in last month	1.0	1.7	3.7	0.2	1.9	1.2
Number of children fathered	1.0	1.2	2.6	0.7	-0.6	1.6
Health satisfaction	1.0	1.2	1.8	0.4	1.3	1.4
Emphysema/chronic bronchitis	1.0	1.2	2.1	0.7	-1.4	0.9
Knee pain experienced in last month	1.0	1.6	3.9	0.9	-0.0	2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.4	-0.3	-1.8	-0.2
Ever had bowel cancer screening	1.0	1.1	2.5	0.5	1.6	-0.8
Ever smoked	1.0	1.7	2.7	1.3	-1.0	1.6
Waist Hip Ratio (WHR)	0.9	4.3	7.3	-0.5	-2.3	2.7
Impedance of leg (right)	0.9	4.4	8.7	1.6	1.3	3.0
Trunk fat mass	0.9	4.0	9.0	3.0	-1.1	1.3
Waist circumference	0.9	3.2	4.4	1.6	-1.7	2.1
Hearing difficulty/problems with background noise	0.9	1.4	3.0	1.7	1.0	-0.5
Diabetes (self-reported)	0.9	1.3	2.4	-0.9	-0.8	1.6
Length of working week for main job	0.9	1.0	2.8	-1.7	-0.3	-0.1
Whole body fat mass	0.9	3.7	8.0	2.8	-1.1	1.4
Pulse rate, automated reading	0.9	3.1	8.1	-2.8	-0.6	0.8
Arm fat percentage (left)	0.9	3.7	7.0	2.6	-1.3	1.5
Medication: Paracetamol	0.9	1.4	3.6	-0.8	1.9	0.2
Fractured/broken bones in last 5 years	0.9	1.1	2.9	0.7	0.0	1.7
Diastolic blood pressure, automated reading	0.9	2.8	5.6	1.5	-2.4	0.8
Intelligence (Savage-Jansen 2018)	0.8	2.6	7.3	0.4	-2.7	0.5
Rheumatoid Arthritis	0.8	1.1	1.9	1.4	-0.6	1.0
Triglycerides	0.8	1.3	3.2	-0.5	0.6	1.8
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.6	1.3	-0.9	-0.6
Severe depression (siblings)	0.8	0.9	1.9	0.4	1.4	-0.8
Hand grip strength (right)	0.8	2.2	3.0	-1.1	-1.5	-1.7
Chronic bronchitis/emphysema (father)	0.8	0.9	1.6	1.3	0.6	0.9
High blood pressure (mother)	0.8	1.1	2.8	0.8	1.7	-0.0
Impedance of leg (left)	0.8	3.9	7.4	1.7	1.0	2.7
Financial difficulties in last 2 years	0.8	1.0	1.3	1.0	1.0	1.1
Arm fat percentage (right)	0.8	3.1	6.4	2.5	-1.1	1.3
Alcohol intake versus 10 years previously	0.8	1.2	2.8	-0.7	-0.4	1.7
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	5.0	-1.7	-0.8	-2.2
Noisy workplace	0.8	1.0	1.5	1.2	0.3	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.9	1.4	0.9	-0.1
Pulse wave Arterial Stiffness index	0.8	0.9	1.7	0.9	1.3	0.6
Gout (self-reported)	0.8	1.2	1.6	-0.8	-1.1	1.3
Forced vital capacity (FVC), Best measure	0.8	2.8	6.4	-1.4	-0.3	-2.5
Comparative body size at age 10	0.8	2.2	3.1	-1.8	-1.7	0.8
Pulse wave peak to peak time	0.8	0.9	1.9	-0.6	-1.4	-0.7
Leg fat mass (right)	0.8	3.3	6.8	2.6	-0.9	1.5
Illnesses of father: None of the above (group 1)	0.8	1.0	1.4	-0.6	-1.2	-1.1
Medication: Blood pressure	0.8	1.5	3.9	0.7	-2.0	0.3
Medication: Atorvastatin	0.8	1.0	2.7	1.7	-0.6	0.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.5	1.0	1.2	0.6
Leg fat mass (left)	0.8	3.3	7.0	2.6	-1.0	1.4
Verbal and Numeric Reasoning (VNR)	0.7	1.8	3.7	-0.7	-1.9	-1.1
Cardiovascular Disease	0.7	2.5	6.9	0.6	-0.2	2.6
Lung FVC	0.7	3.4	7.7	-1.5	0.6	-2.8
Medication: Metformin	0.7	1.0	2.5	0.3	-0.7	1.6
Multivitamins +/- minerals	0.7	0.9	1.5	0.8	1.2	-0.6
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.3	0.8	1.1	0.6
Medication: Allopurinol	0.7	0.9	1.9	-1.4	-0.8	0.4
Leg pain on walking	0.7	0.9	1.1	-1.1	1.0	0.6
Breast cancer (self-reported)	0.7	0.8	1.5	1.2	0.9	-0.3
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.4	-0.8	-0.8	1.2
Alcohol drinker status: Never	0.7	0.8	1.2	1.1	-1.0	0.5
Ulcerative Colitis	0.6	0.9	1.7	1.3	0.3	0.9
Average weekly fortified wine intake	0.6	0.7	1.2	0.2	-0.9	-1.1
Medication: Atenolol	0.6	0.7	1.5	1.2	-0.7	-0.4
Prospective memory result	0.6	0.8	1.2	-0.2	1.1	-1.0
Lung cancer (father)	0.6	0.6	1.1	0.9	-1.1	0.2
Medication: Amlodipine	0.6	0.9	1.2	-0.6	-1.1	-1.1
High blood pressure (siblings)	0.6	0.9	2.6	0.3	1.6	0.1
Alcohol intake frequency.	0.6	1.3	2.4	1.6	0.2	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.0	1.0	-0.6	0.8
Diabetes diagnosed by doctor	0.6	1.0	1.9	-0.8	-0.7	1.4
Hearing aid user	0.6	0.7	0.9	0.7	0.8	0.9
Risk taking	0.6	0.8	1.6	-0.1	-0.9	1.2
Supplements: Calcium	0.6	0.7	1.3	-1.1	-0.9	-0.0
Bipolar Disorder (2018)	0.5	0.8	1.6	-1.3	0.3	-0.9
Irritable Bowel Disease (IBD)	0.5	1.2	3.2	1.8	0.5	-0.5
Ulcerative Colitis (UC)	0.5	0.9	1.9	1.4	0.8	-0.3
Schizophrenia (2014)	0.5	1.1	1.3	1.1	0.8	1.2
Hypothyroidism (self reported)	0.5	1.1	1.3	1.1	-0.8	1.1
Respiratory disease	0.5	1.1	1.5	1.1	0.7	1.2
Lung FEV1/FVC ratio	0.5	2.6	4.5	-2.1	-1.5	-1.0
Relative age of first facial hair	0.5	1.0	3.1	1.7	-0.2	-0.1
Sitting height	0.5	3.5	6.5	0.4	2.0	-2.5
Body mass index (BMI)	0.5	2.2	3.7	1.9	-1.3	1.1
Hair/balding pattern: Pattern 2	0.5	0.7	1.0	-0.9	0.5	-1.0
Forced vital capacity (FVC)	0.5	1.9	3.6	-1.3	-0.6	-1.9
Heart attack	0.5	0.7	1.9	-0.1	-1.4	-0.3
Arm fat mass (right)	0.5	2.2	4.9	2.2	-1.0	0.9
Illnesses of father: Heart disease	0.5	0.7	1.2	-1.1	0.8	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.5	-0.5	-1.2	-1.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.3	-0.8	0.2	-1.1
Arm fat mass (left)	0.5	2.0	4.6	2.1	-0.9	0.8
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	-0.0	1.1	0.7
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.0	0.1	-1.4	-0.2
Heart disease (siblings)	0.5	0.6	0.9	0.3	0.9	0.9
Schizophrenia vs Biploar Disorder	0.4	0.6	1.0	1.0	0.7	0.5
Alzheimer’s Disease (including proxy)	0.4	0.6	1.6	-1.3	-0.5	0.2
Coronary Artery Disease (CAD)	0.4	0.5	1.2	0.2	0.6	1.1
HDL Cholesterol	0.4	0.6	1.1	0.8	-1.1	0.1
Primary Biliary Cirrhosis	0.4	0.5	0.9	-0.9	0.6	0.7
Blood Eosinophil Count	0.4	3.4	6.4	-1.7	0.9	2.5
Systolic Blood Pressure	0.4	1.9	5.3	2.3	0.4	0.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.2	-0.5	0.2	1.1
Supplements: Zinc	0.4	0.4	0.9	0.3	1.0	-0.5
Age when periods started (menarche)	0.4	1.0	1.6	-0.6	1.0	-1.3
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.7	-0.7	0.8	0.6
Medication: Levothyroxine sodium	0.4	0.6	1.4	0.3	0.7	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.6	-0.4	-1.1	-1.3
Hip circumference	0.4	1.6	4.6	2.2	-0.1	0.3
Depression (self-reported)	0.4	0.5	1.5	1.2	-0.2	0.2
Eye problems/disorders: None of the above	0.4	0.4	1.1	1.1	-0.2	-0.4
Leg fat-free mass (right)	0.4	2.3	5.1	0.1	-1.4	-2.3
Long-standing illness, disability or infirmity	0.4	0.6	1.8	0.2	-0.0	1.3
Leg predicted mass (right)	0.4	2.4	5.2	0.0	-1.4	-2.3
Mother’s age at death	0.4	0.5	1.5	0.1	0.1	-1.2
Illnesses of father: High blood pressure	0.4	0.5	1.4	-0.2	-0.0	1.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.3	0.5	1.1	0.1
Bipolar Disorder or Schizophrenia	0.3	0.7	1.7	0.6	1.3	-0.0
Crohns Disease (2017)	0.3	0.7	1.8	1.4	0.2	-0.4
Breast Cancer	0.3	0.8	1.0	-1.0	-1.0	0.8
Bipolar Disorder (2011)	0.3	0.3	0.7	0.3	0.1	-0.9
Crohns Disease (2012)	0.3	0.4	1.2	1.1	0.1	0.2
LDL Cholesterol	0.3	0.5	1.4	0.3	-1.2	0.4
Heel T-Score	0.3	2.6	4.7	0.1	-2.2	-1.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.5	-0.5	0.7	0.4
Angina	0.3	0.4	0.6	-0.7	0.8	-0.3
Leg fat-free mass (left)	0.3	1.6	3.2	0.2	-1.2	-1.8
Relative age voice broke	0.3	0.5	0.8	0.9	-0.1	-0.9
Leg predicted mass (left)	0.3	1.6	3.1	0.2	-1.3	-1.8
Allergy	0.3	0.6	1.4	-0.7	-1.2	-0.0
Weight	0.3	1.7	3.5	1.9	-1.2	-0.1
Trunk fat-free mass	0.3	1.5	3.5	0.6	-0.7	-1.9
Hair/balding pattern: Pattern 3	0.3	0.4	0.9	0.9	0.6	-0.1
Pulse rate	0.3	0.5	1.1	-0.2	-1.1	0.7
Medication: Cholesterol lowering	0.3	0.4	1.1	-0.3	1.1	0.3
Trunk predicted mass	0.3	1.5	3.6	0.7	-0.8	-1.9
Peak expiratory flow (PEF)	0.3	0.7	0.9	-1.0	-0.9	-0.5
Glaucoma (self-reported)	0.3	0.4	1.0	0.2	-0.3	1.0
Birth weight	0.3	0.6	0.9	1.0	0.8	-0.4
Whole body fat-free mass	0.3	1.6	3.7	0.4	-0.9	-1.9
Friendships satisfaction	0.3	0.4	0.8	0.9	-0.5	-0.4
Eye problems/disorders: Cataract	0.3	0.3	1.0	-1.0	0.2	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	0.9	-0.8	-0.9	-0.3
Whole body water mass	0.3	1.6	4.0	0.5	-0.7	-2.0
Impedance of whole body	0.3	1.8	4.0	0.8	0.9	2.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	-0.7	0.3	-0.3
Alzheimer’s Disease (in father)	0.2	0.3	0.5	-0.4	-0.3	0.7
HbA1C	0.2	0.3	0.7	0.1	0.2	0.9
Lupus	0.2	0.3	0.9	0.3	-1.0	0.0
BMI	0.2	1.1	1.8	0.9	-1.3	0.8
Height	0.2	4.3	12.7	0.3	-0.3	-3.6
Allergy or Eczema	0.2	0.6	0.9	-0.6	0.9	-0.8
Systolic blood pressure, automated reading	0.2	0.6	1.8	1.3	0.2	0.2
Diabetes (mother)	0.2	0.3	0.7	0.8	0.2	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.0	0.4	-1.0	-0.3
High blood pressure	0.2	0.5	1.3	-0.5	-0.0	1.2
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.0	-0.4	1.0	-0.6
Had menopause	0.2	0.3	0.8	0.3	-0.0	-0.9
Had other major operations	0.2	0.2	0.4	0.6	0.5	0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.3	-0.4	0.5	-0.5
Fluid intelligence score	0.2	0.5	1.2	-0.3	-0.4	-1.1
Standing height	0.2	2.3	6.8	0.2	0.2	-2.6
Arm fat-free mass (right)	0.2	1.1	1.6	1.1	-0.7	-1.3
Exposure to tobacco smoke outside home	0.2	0.2	0.4	0.6	-0.6	0.2
Medication: Blood pressure	0.2	0.3	0.7	-0.2	0.8	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.5	-0.7	-0.3	0.6
Arm predicted mass (right)	0.2	1.1	1.7	1.1	-0.6	-1.3
Hypertension (Self-reported)	0.2	0.4	1.1	-0.1	0.3	1.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.4	-0.6	0.4	0.7
Asthma (self-reported)	0.2	0.4	0.5	0.6	0.7	0.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	0.7	-0.2	-0.4
Basal metabolic rate	0.2	1.2	2.0	0.8	-1.1	-1.4
Arm fat-free mass (left)	0.2	1.1	2.1	1.0	-0.4	-1.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	0.4	0.1	-0.7
Vascular/heart problems diagnosed by doctor	0.2	0.7	1.3	0.8	-0.4	-1.1
Alcohol drinker status: Previous	0.2	0.2	0.3	0.4	0.4	0.6
Arm predicted mass (left)	0.2	1.2	1.9	1.2	-0.3	-1.4
Ovarian Cancer	0.1	0.1	0.2	-0.3	-0.1	-0.4
Fasting Glucose	0.1	0.2	0.3	0.3	-0.6	0.4
Blood Platelet Count	0.1	1.7	3.2	-0.1	-1.3	1.8
Blood Red Count	0.1	0.6	0.9	-1.0	0.9	0.2
Blood White Count	0.1	0.9	1.0	1.0	0.8	1.0
Supplements: Glucosamine	0.1	0.1	0.4	0.6	0.1	-0.0
Time employed in main current job	0.1	0.1	0.2	0.3	-0.5	-0.3
Asthma	0.1	0.2	0.3	0.3	0.5	0.6
Impedance of arm (left)	0.1	0.3	0.6	0.3	0.2	0.8
Pulse wave reflection index	0.1	0.2	0.4	-0.2	-0.3	0.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.6	-0.0	-0.8	-0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	0.4	-0.0	0.4
Angina (self-reported)	0.1	0.2	0.4	-0.3	0.6	-0.1
Comparative height size at age 10	0.1	0.7	1.2	0.9	-0.5	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.5	-0.2	0.1
Hair Pigment	0.0	0.5	0.9	0.9	0.6	0.3
Tanning	0.0	0.2	0.5	0.3	-0.7	0.2
Medication: Simvastatin	0.0	0.0	0.1	-0.0	-0.1	0.3
Impedance of arm (right)	0.0	0.2	0.4	0.1	0.6	0.5
Osteoporosis (self-reported)	0.0	0.0	0.0	0.1	-0.1	-0.1
Basal cell carcinoma (self-reported)	0.0	0.0	0.1	-0.3	-0.2	0.1

Hub : Genes

CELF4

Models

Trait associations