Hub : Traits :

Frequency of depressed mood in last 2 weeks

7 significantly associated models · 6 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 7 11553163 12967449 1 1 3.4e-07 1.3e-06 1.0e+00 100 TMEM106B
2 9 95518076 96913764 1 2 1.6e-07 2.4e-08 6.0e-02 89 FAM120AOS
3 10 64531160 65911294 1 1 2.0e-07 1.0e-05 9.2e-01 100 JMJD1C-AS1
4 18 34124783 35844220 1 1 9.5e-08 1.5e-10 7.2e-06 51 CELF4
5 20 46840115 48603940 2 1 3.6e-07 1.1e-06 1.5e-03 57 ZFAS1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in mother) 1.66 1 0 0.0 0.00 1.00000 TMEM106B
Alzheimer’s Disease (in father) 3.22 2 0 0.0 0.00 1.00000 JMJD1C-AS1 ZFAS1
Alzheimer’s Disease (including proxy) 2.27 1 0 0.0 0.00 1.00000 TMEM106B
Major Depression (MDD) 7.59 2 0 0.0 0.00 1.00000 FAM120AOS TMEM106B
Reaction Time 2.07 1 0 0.0 0.00 1.00000 ZFAS1
Verbal and Numeric Reasoning (VNR) 5.85 3 2 6.1 0.55 0.44767 FAM120AOS JMJD1C-AS1 ZFAS1
Breast Cancer 0.99 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Bipolar Disorder 2.29 1 0 0.0 0.00 1.00000 FAM120AOS
Body Mass Index (BMI) (2010) 2.14 1 0 0.0 0.00 1.00000 ZFAS1
HDL Cholesterol 1.32 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Lupus 1.46 1 0 0.0 0.00 1.00000 FAM120AOS
Neuroticism 3.32 2 0 0.0 0.00 1.00000 CELF4 FAM120AOS
Schizophrenia 2.36 2 0 0.0 0.00 1.00000 FAM120AOS ZFAS1
Triglycerides 2.25 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Blood Platelet Count 1.29 2 1 3.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Blood Red Count 0.76 2 0 0.0 0.00 1.00000 JMJD1C-AS1 ZFAS1
Blood White Count 1.36 1 1 3.0 0.00 1.00000 JMJD1C-AS1
Heel T-Score 1.62 2 1 3.0 0.00 1.00000 FAM120AOS TMEM106B
BMI 1.99 4 1 3.0 0.31 0.69325 FAM120AOS JMJD1C-AS1 TMEM106B ZFAS1
Height 1.58 4 2 6.1 -0.21 0.79278 FAM120AOS JMJD1C-AS1 TMEM106B ZFAS1
Waist Hip Ratio (WHR) 0.79 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Systolic Blood Pressure 1.31 1 1 3.0 0.00 1.00000 ZFAS1
Allergy or Eczema 1.28 1 0 0.0 0.00 1.00000 TMEM106B
Cardiovascular Disease 0.97 1 0 0.0 0.00 1.00000 TMEM106B
Respiratory disease 1.96 2 0 0.0 0.00 1.00000 TMEM106B ZFAS1
Lung FEV1/FVC ratio 2.38 3 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1 ZFAS1
Lung FVC 1.63 2 0 0.0 0.00 1.00000 JMJD1C-AS1 ZFAS1
Neuroticism 7.71 3 2 6.1 -1.00 0.00037 CELF4 FAM120AOS TMEM106B
Chronotype (morning person) 2.32 2 0 0.0 0.00 1.00000 CELF4 FAM120AOS
Hair Pigment 0.21 2 0 0.0 0.00 1.00000 JMJD1C-AS1 ZFAS1
Hand grip strength (left) 1.66 1 0 0.0 0.00 1.00000 FAM120AOS
Number of treatments/medications taken 2.51 1 0 0.0 0.00 1.00000 TMEM106B
Sensitivity / hurt feelings 3.20 2 0 0.0 0.00 1.00000 CELF4 FAM120AOS
Hearing difficulty/problems: Yes 3.16 1 0 0.0 0.00 1.00000 FAM120AOS
Other serious medical condition/disability diagnosed by doctor 2.54 1 0 0.0 0.00 1.00000 FAM120AOS
Systolic blood pressure, automated reading 1.00 1 0 0.0 0.00 1.00000 ZFAS1
Angina 1.71 1 0 0.0 0.00 1.00000 TMEM106B
Vitamin and mineral supplements 1.90 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Medication: Co-codamol 3.18 1 0 0.0 0.00 1.00000 FAM120AOS
Medication: Metformin 1.55 1 0 0.0 0.00 1.00000 TMEM106B
Pack years adult smoking proportion 4.62 1 1 3.0 0.00 1.00000 JMJD1C-AS1
Impedance of leg (right) 1.73 3 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1 TMEM106B
Trunk fat percentage 1.31 2 0 0.0 0.00 1.00000 CELF4 ZFAS1
Hand grip strength (right) 1.45 2 0 0.0 0.00 1.00000 FAM120AOS ZFAS1
Townsend deprivation index at recruitment 3.31 1 0 0.0 0.00 1.00000 FAM120AOS
Current tobacco smoking 1.94 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Fed-up feelings 5.08 3 0 0.0 1.00 0.00128 CELF4 FAM120AOS JMJD1C-AS1
Frequency of unenthusiasm / disinterest in last 2 weeks 13.48 5 1 3.0 0.97 0.00094 CELF4 FAM120AOS JMJD1C-AS1 TMEM106B ZFAS1
Taking other prescription medications 2.94 2 0 0.0 0.00 1.00000 CELF4 TMEM106B
Age when periods started (menarche) 1.07 1 0 0.0 0.00 1.00000 FAM120AOS
Heel bone mineral density (BMD) T-score, automated (left) 1.09 1 0 0.0 0.00 1.00000 FAM120AOS
Qualifications: CSEs or equivalent 2.21 1 0 0.0 0.00 1.00000 JMJD1C-AS1
High blood pressure 1.03 1 0 0.0 0.00 1.00000 TMEM106B
Stomach or abdominal pain in last month 3.53 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Supplements: Glucosamine 1.37 1 0 0.0 0.00 1.00000 TMEM106B
Sitting height 1.31 1 1 3.0 0.00 1.00000 ZFAS1
Body mass index (BMI) 2.45 3 0 0.0 0.00 1.00000 JMJD1C-AS1 TMEM106B ZFAS1
Impedance of leg (left) 1.76 3 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1 TMEM106B
Trunk fat mass 0.89 2 0 0.0 0.00 1.00000 CELF4 ZFAS1
Waist circumference 1.38 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Nervous feelings 3.11 1 0 0.0 0.00 1.00000 CELF4
Frequency of tenseness / restlessness in last 2 weeks 10.50 5 0 0.0 0.99 0.00081 CELF4 FAM120AOS JMJD1C-AS1 TMEM106B ZFAS1
Hearing difficulty/problems with background noise 3.35 2 0 0.0 0.00 1.00000 FAM120AOS ZFAS1
Had other major operations 2.60 1 0 0.0 0.00 1.00000 FAM120AOS
Forced vital capacity (FVC) 2.85 1 1 3.0 0.00 1.00000 ZFAS1
Heel bone mineral density (BMD) T-score, automated (right) 1.34 1 0 0.0 0.00 1.00000 FAM120AOS
Ever unenthusiastic/disinterested for a whole week 3.96 1 0 0.0 0.00 1.00000 FAM120AOS
Qualifications: None of the above 7.19 4 1 3.0 0.70 0.18930 CELF4 FAM120AOS JMJD1C-AS1 ZFAS1
Financial difficulties in last 2 years 5.53 3 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1 TMEM106B
Heart attack 2.23 2 0 0.0 0.00 1.00000 TMEM106B ZFAS1
Allergy 1.12 1 0 0.0 0.00 1.00000 TMEM106B
Pain all over the body in last month 4.28 2 0 0.0 0.00 1.00000 FAM120AOS TMEM106B
Fluid intelligence score 3.00 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Illnesses of siblings 1.46 1 0 0.0 0.00 1.00000 TMEM106B
Neuroticism score 9.85 4 3 9.1 0.98 0.00445 CELF4 FAM120AOS JMJD1C-AS1 TMEM106B
Impedance of arm (right) 2.43 3 1 3.0 0.00 1.00000 FAM120AOS JMJD1C-AS1 TMEM106B
Arm fat percentage (right) 2.05 2 1 3.0 0.00 1.00000 FAM120AOS ZFAS1
Trunk fat-free mass 0.67 2 0 0.0 0.00 1.00000 JMJD1C-AS1 ZFAS1
Alcohol intake versus 10 years previously 1.73 1 0 0.0 0.00 1.00000 TMEM106B
Worrier / anxious feelings 3.79 2 0 0.0 0.00 1.00000 FAM120AOS TMEM106B
Frequency of tiredness / lethargy in last 2 weeks 9.28 5 0 0.0 0.99 0.00032 CELF4 FAM120AOS JMJD1C-AS1 TMEM106B ZFAS1
Falls in the last year 3.46 1 0 0.0 0.00 1.00000 FAM120AOS
Number of live births 1.43 1 0 0.0 0.00 1.00000 FAM120AOS
Forced expiratory volume in 1-second (FEV1) 2.00 1 0 0.0 0.00 1.00000 ZFAS1
Happiness 5.16 1 1 3.0 0.00 1.00000 ZFAS1
Noisy workplace 2.36 1 0 0.0 0.00 1.00000 FAM120AOS
Qualifications: A levels/AS levels or equivalent 4.89 3 0 0.0 -0.62 0.37957 FAM120AOS JMJD1C-AS1 ZFAS1
Asthma 1.35 1 0 0.0 0.00 1.00000 ZFAS1
Medication: Ibuprofen (e.g. Nurofen) 2.32 1 0 0.0 0.00 1.00000 FAM120AOS
Depression (self-reported) 4.06 1 0 0.0 0.00 1.00000 TMEM106B
Forced expiratory volume in 1-second (FEV1), Best measure 2.85 3 0 0.0 0.00 1.00000 FAM120AOS TMEM106B ZFAS1
Impedance of arm (left) 2.49 3 1 3.0 0.00 1.00000 FAM120AOS JMJD1C-AS1 TMEM106B
Arm fat mass (right) 1.25 1 0 0.0 0.00 1.00000 ZFAS1
Trunk predicted mass 0.67 2 0 0.0 0.00 1.00000 JMJD1C-AS1 ZFAS1
Standing height 1.87 4 1 3.0 0.24 0.75718 FAM120AOS JMJD1C-AS1 TMEM106B ZFAS1
Tense / 'highly strung' 9.64 4 2 6.1 0.97 0.00482 CELF4 FAM120AOS TMEM106B ZFAS1
Seen doctor (GP) for nerves, anxiety, tension or depression 6.50 2 1 3.0 0.00 1.00000 CELF4 TMEM106B
Birth weight of first child 2.08 1 0 0.0 0.00 1.00000 ZFAS1
Ever highly irritable/argumentative for 2 days 4.32 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Loud music exposure frequency 2.23 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Qualifications: O levels/GCSEs or equivalent 3.84 3 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1 ZFAS1
Medication: Paracetamol 4.05 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Headache pain in last month 2.17 1 0 0.0 0.00 1.00000 FAM120AOS
Gout (self-reported) 1.16 1 0 0.0 0.00 1.00000 FAM120AOS
High blood pressure (siblings) 2.29 1 0 0.0 0.00 1.00000 TMEM106B
Forced vital capacity (FVC), Best measure 3.34 3 1 3.0 0.00 1.00000 FAM120AOS TMEM106B ZFAS1
Body fat percentage 1.87 2 0 0.0 0.00 1.00000 CELF4 ZFAS1
Leg fat percentage (right) 2.72 3 1 3.0 0.00 1.00000 CELF4 FAM120AOS ZFAS1
Arm fat-free mass (right) 0.94 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Exposure to tobacco smoke outside home 2.49 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Comparative body size at age 10 5.31 1 1 3.0 0.00 1.00000 FAM120AOS
Number of full brothers 3.01 1 0 0.0 0.00 1.00000 FAM120AOS
Worry too long after embarrassment 1.79 1 0 0.0 0.00 1.00000 CELF4
Seen a psychiatrist for nerves, anxiety, tension or depression 3.83 1 0 0.0 0.00 1.00000 TMEM106B
Wheeze or whistling in the chest in last year 2.18 1 0 0.0 0.00 1.00000 FAM120AOS
Number of children fathered 2.65 1 0 0.0 0.00 1.00000 ZFAS1
Reason for reducing amount of alcohol drunk: Health precaution 1.54 1 0 0.0 0.00 1.00000 CELF4
Age at first live birth 2.74 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Qualifications: College or University degree 5.46 4 1 3.0 -0.69 0.20091 CELF4 FAM120AOS JMJD1C-AS1 ZFAS1
Medication for pain relief, constipation, heartburn 4.00 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Neck or shoulder pain in last month 3.29 1 0 0.0 0.00 1.00000 FAM120AOS
Angina (self-reported) 2.08 1 0 0.0 0.00 1.00000 TMEM106B
Mean time to correctly identify matches 1.56 1 0 0.0 0.00 1.00000 ZFAS1
Whole body fat mass 1.11 2 0 0.0 0.00 1.00000 CELF4 ZFAS1
Leg fat mass (right) 1.64 2 0 0.0 0.00 1.00000 FAM120AOS ZFAS1
Arm predicted mass (right) 0.89 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Pulse rate, automated reading 0.43 1 0 0.0 0.00 1.00000 CELF4
Comparative height size at age 10 2.80 3 1 3.0 0.00 1.00000 FAM120AOS TMEM106B ZFAS1
Suffer from 'nerves' 3.58 2 0 0.0 0.00 1.00000 CELF4 TMEM106B
Overall health rating 5.74 4 1 3.0 1.00 0.00022 CELF4 FAM120AOS JMJD1C-AS1 TMEM106B
Family relationship satisfaction 5.37 2 0 0.0 0.00 1.00000 TMEM106B ZFAS1
Illness, injury, bereavement, stress in last 2 years 4.25 2 0 0.0 0.00 1.00000 FAM120AOS TMEM106B
Medication: Aspirin 1.99 1 0 0.0 0.00 1.00000 TMEM106B
Illnesses of siblings: Diabetes 1.89 1 0 0.0 0.00 1.00000 FAM120AOS
Whole body fat-free mass 0.53 2 0 0.0 0.00 1.00000 JMJD1C-AS1 ZFAS1
Arm fat percentage (left) 2.09 2 1 3.0 0.00 1.00000 FAM120AOS ZFAS1
Mood swings 9.07 4 1 3.0 0.98 0.00459 CELF4 FAM120AOS JMJD1C-AS1 TMEM106B
Loneliness, isolation 14.84 5 1 3.0 0.98 0.00047 CELF4 FAM120AOS JMJD1C-AS1 TMEM106B ZFAS1
Long-standing illness, disability or infirmity 4.07 2 0 0.0 0.00 1.00000 FAM120AOS TMEM106B
Diabetes diagnosed by doctor 1.29 1 0 0.0 0.00 1.00000 TMEM106B
Friendships satisfaction 3.20 1 0 0.0 0.00 1.00000 ZFAS1
Qualifications: nursing, teaching 4.08 2 0 0.0 0.00 1.00000 CELF4 JMJD1C-AS1
Eye problems/disorders: Cataract 1.88 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Medication for cholesterol 1.88 1 0 0.0 0.00 1.00000 TMEM106B
Back pain experienced in last month 2.50 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Osteoarthritis (self-reported) 2.45 1 0 0.0 0.00 1.00000 FAM120AOS
Medication: Aspirin 2.00 1 0 0.0 0.00 1.00000 TMEM106B
Smoking status: Current 2.00 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.19 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Whole body water mass 0.52 2 0 0.0 0.00 1.00000 JMJD1C-AS1 ZFAS1
Arm fat mass (left) 1.26 1 0 0.0 0.00 1.00000 ZFAS1
Number of self-reported non-cancer illnesses 3.48 1 0 0.0 0.00 1.00000 TMEM106B
Average weekly champagne plus white wine intake 2.84 1 0 0.0 0.00 1.00000 ZFAS1
Miserableness 7.31 4 1 3.0 0.95 0.01328 CELF4 FAM120AOS JMJD1C-AS1 TMEM106B
Guilty feelings 4.03 3 0 0.0 1.00 0.00476 CELF4 FAM120AOS TMEM106B
Financial situation satisfaction 3.64 2 0 0.0 0.00 1.00000 CELF4 TMEM106B
Pain type(s) experienced in last month: Hip pain 3.92 1 0 0.0 0.00 1.00000 FAM120AOS
High cholesterol (Self-reported) 1.13 1 0 0.0 0.00 1.00000 TMEM106B
Medication: Paracetamol 2.47 1 0 0.0 0.00 1.00000 FAM120AOS
Leg fat percentage (left) 2.83 3 1 3.0 0.00 1.00000 CELF4 FAM120AOS ZFAS1
Arm fat-free mass (left) 0.97 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Number of operations (self-reported) 3.97 1 0 0.0 0.00 1.00000 FAM120AOS
Irritability 6.15 4 1 3.0 0.96 0.00807 CELF4 FAM120AOS TMEM106B ZFAS1
Risk taking 2.82 2 0 0.0 0.00 1.00000 FAM120AOS TMEM106B
Diastolic blood pressure, automated reading 0.92 1 0 0.0 0.00 1.00000 ZFAS1
Ever depressed for a whole week 3.83 2 0 0.0 0.00 1.00000 TMEM106B ZFAS1
Unable to work because of sickness or disability 4.20 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Vascular/heart problems diagnosed by doctor 1.31 1 0 0.0 0.00 1.00000 TMEM106B
Pain experienced in last month 4.26 2 0 0.0 0.00 1.00000 CELF4 FAM120AOS
Heart attack/myocardial infarction (self-reported) 2.16 1 0 0.0 0.00 1.00000 TMEM106B
Alcohol drinker status: Previous 1.74 1 0 0.0 0.00 1.00000 TMEM106B
Pack years of smoking 3.98 1 1 3.0 0.00 1.00000 JMJD1C-AS1
Impedance of whole body 1.83 3 1 3.0 0.00 1.00000 FAM120AOS JMJD1C-AS1 TMEM106B
Leg fat mass (left) 1.67 2 0 0.0 0.00 1.00000 FAM120AOS ZFAS1
Arm predicted mass (left) 0.95 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.42
GTEx Adipose Visceral Omentum 0 0.0000 1.49
GTEx Adrenal Gland 0 0.0000 1.44
GTEx Artery Aorta 0 0.0000 1.43
GTEx Artery Coronary 0 0.0000 1.59
GTEx Artery Tibial 0 0.0000 1.43
GTEx Brain Caudate basal ganglia 0 0.0000 1.38
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.44
GTEx Brain Cerebellum 0 0.0000 1.40
GTEx Brain Cortex 0 0.0000 1.47
GTEx Brain Frontal Cortex BA9 0 0.0000 1.40
GTEx Brain Hippocampus 0 0.0000 1.49
GTEx Brain Hypothalamus 0 0.0000 1.50
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.40
GTEx Brain Putamen basal ganglia 0 0.0000 1.37
GTEx Breast Mammary Tissue 0 0.0000 1.49
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.52
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.46
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.49
GTEx Cells Transformed fibroblasts 0 0.0000 1.45
GTEx Colon Sigmoid 0 0.0000 1.50
GTEx Colon Transverse 1 0.0484 1.45
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.53
GTEx Esophagus Mucosa 0 0.0000 1.37
GTEx Esophagus Muscularis 0 0.0000 1.48
GTEx Heart Atrial Appendage 1 0.0633 1.56
GTEx Heart Left Ventricle 0 0.0000 1.52
GTEx Liver 0 0.0000 1.46
GTEx Lung 0 0.0000 1.46
GTEx Muscle Skeletal 0 0.0000 1.45
GTEx Nerve Tibial 0 0.0000 1.44
GTEx Ovary 0 0.0000 1.55
GTEx Pancreas 0 0.0000 1.43
GTEx Pituitary 0 0.0000 1.51
GTEx Prostate 0 0.0000 1.52
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.51
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.44
GTEx Small Intestine Terminal Ileum 0 0.0000 1.62
GTEx Spleen 0 0.0000 1.50
GTEx Stomach 0 0.0000 1.46
GTEx Testis 1 0.0317 1.42
GTEx Thyroid 0 0.0000 1.42
GTEx Uterus 0 0.0000 1.62
GTEx Vagina 0 0.0000 1.49
GTEx Whole Blood 0 0.0000 1.48
METSIM Adipose 0 0.0000 1.35
NTR Blood 0 0.0000 1.40
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.42
YFS Blood 2 0.0433 1.30
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.36
TCGA Breast Tumor 0 0.0000 1.32
TCGA Breast Normal 0 0.0000 1.27
TCGA Ovarian Tumor 0 0.0000 1.39
TCGA Prostate Tumor 0 0.0000 1.31