Hub : Traits :

Average weekly red wine intake

62 significantly associated models · 20 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 43899918 45698128 1 1 4.2e-08 6.1e-08 1.0e+00 100 CAMKMT
2 2 57961229 59974201 1 1 2.3e-09 1.0e-04 1.3e-01 85 AC007092.1
3 7 140705484 142344964 5 1 5.8e-09 1.1e-14 1.8e-07 54 WEE2-AS1
4 10 64195778 65911294 2 1 2.1e-08 3.3e-09 6.3e-04 67 JMJD1C
5 11 56666189 58284951 6 2 3.2e-10 2.3e-09 1.0e+00 100 CTNND1 ZDHHC5
6 11 65549606 66963425 1 1 1.4e-08 9.8e-09 1.0e+00 100 DPP3
7 12 123049746 124591385 2 1 2.0e-07 1.5e-06 2.4e-01 94 CDK2AP1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Major Depression (MDD) 4.90 1 1 3.0 0.00 1.0000 ZDHHC5
Verbal and Numeric Reasoning (VNR) 3.03 2 0 0.0 0.00 1.0000 CAMKMT ZDHHC5
Breast Cancer 2.18 1 0 0.0 0.00 1.0000 DPP3
Ovarian Cancer 1.62 1 0 0.0 0.00 1.0000 CDK2AP1
Body Mass Index (BMI) (2010) 3.15 1 0 0.0 0.00 1.0000 AC007092.1
HDL Cholesterol 2.35 1 0 0.0 0.00 1.0000 JMJD1C
Schizophrenia 2.52 2 0 0.0 0.00 1.0000 CDK2AP1 ZDHHC5
Triglycerides 5.03 2 1 3.0 0.00 1.0000 AC007092.1 JMJD1C
Blood Eosinophil Count 1.82 4 1 3.0 0.91 0.0873 CDK2AP1 CTNND1 JMJD1C ZDHHC5
Blood Platelet Count 9.54 3 3 9.1 0.00 1.0000 CDK2AP1 JMJD1C ZDHHC5
Blood Red Count 1.39 4 1 3.0 0.61 0.3922 CAMKMT DPP3 JMJD1C ZDHHC5
Blood White Count 3.30 2 1 3.0 0.00 1.0000 AC007092.1 JMJD1C
Heel T-Score 2.72 3 2 6.1 0.00 1.0000 CDK2AP1 JMJD1C ZDHHC5
BMI 4.02 3 3 9.1 0.00 1.0000 AC007092.1 CAMKMT JMJD1C
Height 3.68 4 4 12.1 -0.82 0.1817 CAMKMT CDK2AP1 JMJD1C ZDHHC5
Waist Hip Ratio (WHR) 2.11 2 1 3.0 0.00 1.0000 CDK2AP1 JMJD1C
Systolic Blood Pressure 2.09 2 1 3.0 0.00 1.0000 CTNND1 ZDHHC5
Allergy or Eczema 2.59 1 0 0.0 0.00 1.0000 CDK2AP1
Type 2 Diabetes (T2D) 2.29 2 0 0.0 0.00 1.0000 AC007092.1 CAMKMT
Lung FEV1/FVC ratio 2.83 2 2 6.1 0.00 1.0000 JMJD1C ZDHHC5
Lung FVC 1.37 2 0 0.0 0.00 1.0000 CDK2AP1 DPP3
Neuroticism 3.42 2 1 3.0 0.00 1.0000 CTNND1 ZDHHC5
Chronotype (morning person) 4.19 3 0 0.0 0.00 1.0000 CAMKMT CTNND1 ZDHHC5
Hair Pigment 0.17 1 1 3.0 0.00 1.0000 CDK2AP1
Hand grip strength (left) 1.07 1 0 0.0 0.00 1.0000 ZDHHC5
Sensitivity / hurt feelings 1.76 1 0 0.0 0.00 1.0000 ZDHHC5
Frequency of depressed mood in last 2 weeks 3.95 1 0 0.0 0.00 1.0000 ZDHHC5
Relative age of first facial hair 1.06 1 0 0.0 0.00 1.0000 JMJD1C
Systolic blood pressure, automated reading 1.66 1 0 0.0 0.00 1.0000 ZDHHC5
Diabetes (father) 2.08 1 0 0.0 0.00 1.0000 AC007092.1
Pack years adult smoking proportion 2.26 1 0 0.0 0.00 1.0000 JMJD1C
Leg fat-free mass (left) 1.56 2 1 3.0 0.00 1.0000 AC007092.1 CDK2AP1
Trunk fat percentage 3.28 4 1 3.0 -0.93 0.0719 AC007092.1 CAMKMT JMJD1C ZDHHC5
Hand grip strength (right) 1.25 1 0 0.0 0.00 1.0000 ZDHHC5
Townsend deprivation index at recruitment 2.24 1 0 0.0 0.00 1.0000 ZDHHC5
Fed-up feelings 5.60 2 0 0.0 0.00 1.0000 AC007092.1 ZDHHC5
Frequency of unenthusiasm / disinterest in last 2 weeks 5.77 2 0 0.0 0.00 1.0000 JMJD1C ZDHHC5
Heel bone mineral density (BMD) T-score, automated (left) 1.57 1 0 0.0 0.00 1.0000 CDK2AP1
Hayfever, allergic rhinitis or eczema 2.19 1 0 0.0 0.00 1.0000 CDK2AP1
Sitting height 4.88 3 2 6.1 0.00 1.0000 CAMKMT CDK2AP1 ZDHHC5
Body mass index (BMI) 3.83 3 2 6.1 0.00 1.0000 AC007092.1 CAMKMT JMJD1C
Impedance of leg (left) 0.97 1 0 0.0 0.00 1.0000 CDK2AP1
Leg predicted mass (left) 1.55 2 1 3.0 0.00 1.0000 AC007092.1 CDK2AP1
Trunk fat mass 2.62 2 1 3.0 0.00 1.0000 AC007092.1 JMJD1C
Waist circumference 3.18 2 2 6.1 0.00 1.0000 AC007092.1 JMJD1C
Alcohol usually taken with meals 9.54 3 2 6.1 0.00 1.0000 CTNND1 JMJD1C ZDHHC5
Had menopause 2.25 1 0 0.0 0.00 1.0000 CDK2AP1
Heel bone mineral density (BMD) T-score, automated (right) 1.30 1 0 0.0 0.00 1.0000 CDK2AP1
Qualifications: None of the above 8.53 4 3 9.1 -0.98 0.0225 CAMKMT CDK2AP1 JMJD1C ZDHHC5
Financial difficulties in last 2 years 2.53 1 0 0.0 0.00 1.0000 ZDHHC5
Allergy 2.23 1 0 0.0 0.00 1.0000 CDK2AP1
Diabetes (self-reported) 2.26 1 0 0.0 0.00 1.0000 JMJD1C
Fluid intelligence score 4.24 3 0 0.0 0.00 1.0000 CAMKMT CDK2AP1 ZDHHC5
Illnesses of siblings 3.17 1 0 0.0 0.00 1.0000 AC007092.1
Neuroticism score 3.43 1 1 3.0 0.00 1.0000 ZDHHC5
Weight 2.05 3 2 6.1 0.00 1.0000 AC007092.1 CDK2AP1 JMJD1C
Impedance of arm (right) 2.13 3 1 3.0 0.00 1.0000 AC007092.1 JMJD1C ZDHHC5
Arm fat percentage (right) 3.78 4 1 3.0 -0.95 0.0523 AC007092.1 CAMKMT JMJD1C ZDHHC5
Trunk fat-free mass 2.22 2 1 3.0 0.00 1.0000 CDK2AP1 ZDHHC5
Hip circumference 2.00 2 1 3.0 0.00 1.0000 AC007092.1 CDK2AP1
Alcohol intake versus 10 years previously 3.69 2 0 0.0 0.00 1.0000 CAMKMT CDK2AP1
Worrier / anxious feelings 2.05 1 1 3.0 0.00 1.0000 ZDHHC5
Frequency of tiredness / lethargy in last 2 weeks 5.08 3 1 3.0 0.00 1.0000 CTNND1 JMJD1C ZDHHC5
Forced expiratory volume in 1-second (FEV1) 1.19 1 0 0.0 0.00 1.0000 ZDHHC5
Noisy workplace 2.63 1 0 0.0 0.00 1.0000 JMJD1C
Qualifications: A levels/AS levels or equivalent 7.09 4 2 6.1 0.97 0.0254 CAMKMT CDK2AP1 JMJD1C WEE2-AS1
Prospective memory result 2.85 1 0 0.0 0.00 1.0000 CAMKMT
Forced expiratory volume in 1-second (FEV1), Best measure 1.26 1 0 0.0 0.00 1.0000 ZDHHC5
Impedance of arm (left) 2.02 3 1 3.0 0.00 1.0000 AC007092.1 JMJD1C ZDHHC5
Arm fat mass (right) 3.26 3 1 3.0 0.00 1.0000 AC007092.1 CAMKMT JMJD1C
Trunk predicted mass 2.22 2 1 3.0 0.00 1.0000 CDK2AP1 ZDHHC5
Standing height 3.53 5 3 9.1 0.80 0.1073 AC007092.1 CAMKMT CDK2AP1 JMJD1C ZDHHC5
Breastfed as a baby 2.13 1 0 0.0 0.00 1.0000 CDK2AP1
Tense / 'highly strung' 2.06 1 0 0.0 0.00 1.0000 ZDHHC5
Seen doctor (GP) for nerves, anxiety, tension or depression 2.34 1 0 0.0 0.00 1.0000 ZDHHC5
Peak expiratory flow (PEF) 1.63 1 0 0.0 0.00 1.0000 ZDHHC5
Qualifications: O levels/GCSEs or equivalent 6.33 2 1 3.0 0.00 1.0000 CAMKMT CDK2AP1
Headache pain in last month 1.12 1 0 0.0 0.00 1.0000 ZDHHC5
High blood pressure (siblings) 3.05 2 0 0.0 0.00 1.0000 AC007092.1 JMJD1C
Forced vital capacity (FVC), Best measure 1.00 1 0 0.0 0.00 1.0000 CAMKMT
Body fat percentage 3.82 4 1 3.0 -0.94 0.0619 AC007092.1 CAMKMT JMJD1C ZDHHC5
Leg fat percentage (right) 4.74 3 2 6.1 0.00 1.0000 AC007092.1 CAMKMT JMJD1C
Arm fat-free mass (right) 1.90 2 1 3.0 0.00 1.0000 CDK2AP1 ZDHHC5
Exposure to tobacco smoke outside home 2.19 1 0 0.0 0.00 1.0000 JMJD1C
Comparative body size at age 10 1.47 1 0 0.0 0.00 1.0000 DPP3
Worry too long after embarrassment 3.73 1 1 3.0 0.00 1.0000 ZDHHC5
Age at first live birth 3.44 1 0 0.0 0.00 1.0000 JMJD1C
Qualifications: College or University degree 5.22 6 1 3.0 0.97 0.0011 AC007092.1 CAMKMT CDK2AP1 DPP3 JMJD1C ZDHHC5
Whole body fat mass 2.80 2 1 3.0 0.00 1.0000 AC007092.1 JMJD1C
Leg fat mass (right) 3.40 3 2 6.1 0.00 1.0000 AC007092.1 CAMKMT JMJD1C
Arm predicted mass (right) 1.77 1 1 3.0 0.00 1.0000 CDK2AP1
Pulse rate, automated reading 2.05 2 1 3.0 0.00 1.0000 AC007092.1 ZDHHC5
Alcohol intake frequency. 4.85 4 0 0.0 -0.99 0.0095 CDK2AP1 CTNND1 WEE2-AS1 ZDHHC5
Comparative height size at age 10 3.53 2 1 3.0 0.00 1.0000 CAMKMT CDK2AP1
Number of full sisters 3.07 1 0 0.0 0.00 1.0000 JMJD1C
Overall health rating 3.97 2 0 0.0 0.00 1.0000 JMJD1C ZDHHC5
Age at last live birth 2.91 1 0 0.0 0.00 1.0000 JMJD1C
Whole body fat-free mass 1.85 1 1 3.0 0.00 1.0000 CDK2AP1
Leg fat-free mass (right) 1.40 1 1 3.0 0.00 1.0000 CDK2AP1
Arm fat percentage (left) 3.63 4 1 3.0 -0.95 0.0490 AC007092.1 CAMKMT JMJD1C ZDHHC5
Loneliness, isolation 3.47 1 0 0.0 0.00 1.0000 ZDHHC5
Long-standing illness, disability or infirmity 1.91 1 0 0.0 0.00 1.0000 AC007092.1
Diabetes diagnosed by doctor 2.17 1 0 0.0 0.00 1.0000 JMJD1C
Qualifications: nursing, teaching 5.28 2 0 0.0 0.00 1.0000 CDK2AP1 ZDHHC5
Mineral and other dietary supplements 4.36 2 0 0.0 0.00 1.0000 AC007092.1 DPP3
Osteoarthritis (self-reported) 1.98 1 0 0.0 0.00 1.0000 CDK2AP1
Whole body water mass 1.86 1 1 3.0 0.00 1.0000 CDK2AP1
Leg predicted mass (right) 1.38 1 1 3.0 0.00 1.0000 CDK2AP1
Arm fat mass (left) 3.06 3 1 3.0 0.00 1.0000 AC007092.1 CAMKMT JMJD1C
Guilty feelings 3.23 1 1 3.0 0.00 1.0000 ZDHHC5
Mother's age at death 3.15 1 0 0.0 0.00 1.0000 CTNND1
Supplements: Fish oil (including cod liver oil) 5.17 2 0 0.0 0.00 1.0000 AC007092.1 DPP3
Alcohol drinker status: Never 2.83 1 0 0.0 0.00 1.0000 CDK2AP1
Basal metabolic rate 1.80 2 1 3.0 0.00 1.0000 AC007092.1 CDK2AP1
Leg fat percentage (left) 4.93 3 3 9.1 0.00 1.0000 AC007092.1 CAMKMT JMJD1C
Arm fat-free mass (left) 1.98 2 1 3.0 0.00 1.0000 CDK2AP1 JMJD1C
Average weekly beer plus cider intake 3.80 1 0 0.0 0.00 1.0000 JMJD1C
Diastolic blood pressure, automated reading 3.67 3 1 3.0 0.00 1.0000 CAMKMT CDK2AP1 JMJD1C
Unable to work because of sickness or disability 3.20 1 0 0.0 0.00 1.0000 ZDHHC5
Commuting to job workplace: Cycle 2.77 1 0 0.0 0.00 1.0000 DPP3
Impedance of whole body 1.44 2 0 0.0 0.00 1.0000 AC007092.1 JMJD1C
Leg fat mass (left) 3.40 3 2 6.1 0.00 1.0000 AC007092.1 CAMKMT JMJD1C
Arm predicted mass (left) 1.97 2 1 3.0 0.00 1.0000 CDK2AP1 JMJD1C

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0573 1.54
GTEx Adipose Visceral Omentum 3 0.1473 1.61
GTEx Adrenal Gland 0 0.0000 1.47
GTEx Artery Aorta 1 0.0336 1.49
GTEx Artery Coronary 0 0.0000 1.40
GTEx Artery Tibial 2 0.0532 1.56
GTEx Brain Caudate basal ganglia 1 0.1087 1.65
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.56
GTEx Brain Cerebellum 2 0.1009 1.61
GTEx Brain Cortex 2 0.1932 1.56
GTEx Brain Frontal Cortex BA9 1 0.1082 1.70
GTEx Brain Hippocampus 0 0.0000 1.64
GTEx Brain Hypothalamus 0 0.0000 1.52
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.59
GTEx Brain Putamen basal ganglia 0 0.0000 1.57
GTEx Breast Mammary Tissue 1 0.0507 1.60
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.47
GTEx Breast Mammary Tissue (Female) 1 0.0608 1.51
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.54
GTEx Cells Transformed fibroblasts 2 0.0476 1.53
GTEx Colon Sigmoid 1 0.0684 1.49
GTEx Colon Transverse 0 0.0000 1.61
GTEx Esophagus Gastroesophageal Junction 1 0.0692 1.51
GTEx Esophagus Mucosa 2 0.0602 1.58
GTEx Esophagus Muscularis 4 0.1238 1.51
GTEx Heart Atrial Appendage 1 0.0633 1.47
GTEx Heart Left Ventricle 2 0.1307 1.52
GTEx Liver 0 0.0000 1.65
GTEx Lung 1 0.0348 1.60
GTEx Muscle Skeletal 1 0.0346 1.47
GTEx Nerve Tibial 2 0.0463 1.48
GTEx Ovary 0 0.0000 1.51
GTEx Pancreas 2 0.1225 1.65
GTEx Pituitary 0 0.0000 1.44
GTEx Prostate 0 0.0000 1.62
GTEx Skin Not Sun Exposed Suprapubic 2 0.0813 1.56
GTEx Skin Sun Exposed Lower leg 4 0.1099 1.63
GTEx Small Intestine Terminal Ileum 0 0.0000 1.76
GTEx Spleen 2 0.1417 1.57
GTEx Stomach 0 0.0000 1.57
GTEx Testis 1 0.0317 1.49
GTEx Thyroid 3 0.0750 1.54
GTEx Uterus 0 0.0000 1.47
GTEx Vagina 0 0.0000 1.72
GTEx Whole Blood 0 0.0000 1.45
METSIM Adipose 2 0.0434 1.42
NTR Blood 1 0.0416 1.39
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.49
YFS Blood 1 0.0217 1.35
CommonMind Brain Pre-frontal Cortex 4 0.0744 1.44
TCGA Breast Tumor 0 0.0000 1.53
TCGA Breast Normal 2 0.0475 1.33
TCGA Ovarian Tumor 1 0.0342 1.38
TCGA Prostate Tumor 1 0.0289 1.43