Hub : Traits :

Medication: Atenolol

15 significantly associated models · 5 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 12 111154626 113517494 4 1 8.6e-10 4.5e-16 7.6e-08 56 HECTD4
2 15 90730363 92135418 1 1 9.9e-11 1.7e-09 5.6e-01 99 FES

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 5.50 2 0 0.0 0 1 FES HECTD4
Irritable Bowel Disease (IBD) 6.62 2 0 0.0 0 1 FES HECTD4
Ulcerative Colitis (UC) 4.41 1 0 0.0 0 1 HECTD4
Major Depression (MDD) 8.39 1 0 0.0 0 1 FES
Reaction Time 13.74 2 1 3.0 0 1 FES HECTD4
Breast Cancer 9.07 1 0 0.0 0 1 FES
Body Mass Index (BMI) (2010) 3.74 1 0 0.0 0 1 HECTD4
Coronary Artery Disease (CAD) 13.66 2 0 0.0 0 1 FES HECTD4
LDL Cholesterol 10.86 1 1 3.0 0 1 HECTD4
Lupus 8.51 1 0 0.0 0 1 HECTD4
Primary Biliary Cirrhosis 9.06 1 0 0.0 0 1 HECTD4
Rheumatoid Arthritis 6.22 1 0 0.0 0 1 HECTD4
Schizophrenia 9.26 1 1 3.0 0 1 FES
Blood Eosinophil Count 85.64 1 1 3.0 0 1 HECTD4
Blood Platelet Count 35.96 1 1 3.0 0 1 HECTD4
Blood Red Count 11.88 2 1 3.0 0 1 FES HECTD4
Blood White Count 39.48 2 2 6.1 0 1 FES HECTD4
BMI 2.30 1 0 0.0 0 1 HECTD4
Height 1.78 2 2 6.1 0 1 FES HECTD4
Waist Hip Ratio (WHR) 1.86 1 0 0.0 0 1 HECTD4
Systolic Blood Pressure 45.73 2 2 6.1 0 1 FES HECTD4
Smoking Status 4.60 1 0 0.0 0 1 FES
Allergy or Eczema 9.31 2 1 3.0 0 1 FES HECTD4
Cardiovascular Disease 33.50 2 2 6.1 0 1 FES HECTD4
Hypothyroidism (self reported) 68.96 1 1 3.0 0 1 HECTD4
Respiratory disease 3.91 1 0 0.0 0 1 FES
Lung FEV1/FVC ratio 1.01 1 0 0.0 0 1 HECTD4
Lung FVC 2.61 1 0 0.0 0 1 HECTD4
Neuroticism 2.31 1 0 0.0 0 1 FES
Chronotype (morning person) 3.26 1 0 0.0 0 1 HECTD4
Hair Pigment 1.38 2 2 6.1 0 1 FES HECTD4
Tanning 0.66 1 0 0.0 0 1 HECTD4
Hand grip strength (left) 3.94 1 0 0.0 0 1 FES
Number of treatments/medications taken 11.52 2 1 3.0 0 1 FES HECTD4
Sensitivity / hurt feelings 5.65 1 0 0.0 0 1 FES
Other serious medical condition/disability diagnosed by doctor 4.59 1 0 0.0 0 1 HECTD4
Systolic blood pressure, automated reading 30.29 2 2 6.1 0 1 FES HECTD4
Angina 17.39 1 1 3.0 0 1 FES
Severe depression (siblings) 5.06 1 0 0.0 0 1 FES
Impedance of leg (right) 4.08 2 1 3.0 0 1 FES HECTD4
Leg fat-free mass (left) 5.44 2 1 3.0 0 1 FES HECTD4
Fed-up feelings 5.76 1 0 0.0 0 1 HECTD4
Taking other prescription medications 10.77 1 1 3.0 0 1 HECTD4
High blood pressure 36.17 2 2 6.1 0 1 FES HECTD4
Hayfever, allergic rhinitis or eczema 8.08 2 0 0.0 0 1 FES HECTD4
Diverticular disease/diverticulitis (self-reported) 6.13 1 0 0.0 0 1 HECTD4
Medication: Levothyroxine sodium 48.91 1 1 3.0 0 1 HECTD4
High blood pressure (mother) 28.18 1 1 3.0 0 1 FES
Body mass index (BMI) 2.46 1 0 0.0 0 1 HECTD4
Impedance of leg (left) 4.00 2 1 3.0 0 1 FES HECTD4
Leg predicted mass (left) 5.33 2 1 3.0 0 1 FES HECTD4
Trunk fat mass 2.09 1 0 0.0 0 1 HECTD4
Waist circumference 2.45 1 0 0.0 0 1 HECTD4
Number of incorrect matches in round 3.94 1 0 0.0 0 1 FES
Past tobacco smoking 7.79 2 0 0.0 0 1 FES HECTD4
Alcohol usually taken with meals 5.60 1 0 0.0 0 1 FES
Frequency of tenseness / restlessness in last 2 weeks 3.41 1 0 0.0 0 1 HECTD4
Heart attack 14.02 2 1 3.0 0 1 FES HECTD4
Allergy 6.82 2 0 0.0 0 1 FES HECTD4
Medication: Ramipril 9.01 1 0 0.0 0 1 FES
Medication: Simvastatin 10.85 1 1 3.0 0 1 FES
Illnesses of siblings 12.79 2 0 0.0 0 1 FES HECTD4
Weight 4.89 1 1 3.0 0 1 HECTD4
Impedance of arm (right) 3.05 1 1 3.0 0 1 HECTD4
Trunk fat-free mass 6.57 2 1 3.0 0 1 FES HECTD4
Hip circumference 5.54 1 1 3.0 0 1 HECTD4
Father's age at death 15.99 2 1 3.0 0 1 FES HECTD4
Frequency of tiredness / lethargy in last 2 weeks 2.91 1 0 0.0 0 1 HECTD4
Number of live births 3.80 1 0 0.0 0 1 FES
Asthma 3.34 1 0 0.0 0 1 FES
Medication: Ibuprofen (e.g. Nurofen) 4.92 1 0 0.0 0 1 HECTD4
Medication: Cholesterol lowering 11.94 1 1 3.0 0 1 FES
Medication: Lansoprazole 6.01 1 0 0.0 0 1 HECTD4
Lung cancer (father) 4.25 1 0 0.0 0 1 FES
Illnesses of mother 18.37 1 1 3.0 0 1 FES
Pulse wave Arterial Stiffness index 6.74 1 0 0.0 0 1 FES
Impedance of arm (left) 4.11 1 1 3.0 0 1 HECTD4
Arm fat mass (right) 3.03 1 0 0.0 0 1 HECTD4
Trunk predicted mass 6.63 2 1 3.0 0 1 FES HECTD4
Standing height 1.70 1 1 3.0 0 1 HECTD4
Breastfed as a baby 5.38 1 0 0.0 0 1 FES
Hair/balding pattern: Pattern 4 3.26 1 0 0.0 0 1 FES
Birth weight of first child 27.16 2 2 6.1 0 1 FES HECTD4
Ever highly irritable/argumentative for 2 days 4.17 1 0 0.0 0 1 HECTD4
Blood clot in the leg (DVT) 5.19 1 0 0.0 0 1 HECTD4
Headache pain in last month 7.58 2 0 0.0 0 1 FES HECTD4
Medication for cholesterol, blood pressure or diabetes 24.73 2 1 3.0 0 1 FES HECTD4
Gout (self-reported) 6.22 1 0 0.0 0 1 HECTD4
Hypothyroidism/myxoedema (self-reported) 53.86 1 1 3.0 0 1 HECTD4
Medication: Amlodipine 12.45 1 1 3.0 0 1 FES
Birth weight 17.56 2 2 6.1 0 1 FES HECTD4
High blood pressure (siblings) 18.07 2 1 3.0 0 1 FES HECTD4
Arm fat-free mass (right) 6.31 1 1 3.0 0 1 HECTD4
Exposure to tobacco smoke outside home 3.35 1 0 0.0 0 1 HECTD4
Pulse wave peak to peak time 7.14 1 0 0.0 0 1 FES
Medication: Blood pressure 30.37 2 2 6.1 0 1 FES HECTD4
Angina (self-reported) 17.87 1 1 3.0 0 1 FES
Medication: Allopurinol 5.43 1 0 0.0 0 1 HECTD4
Mean time to correctly identify matches 14.58 2 1 3.0 0 1 FES HECTD4
Heart disease (mother) 9.83 2 0 0.0 0 1 FES HECTD4
Whole body fat mass 2.44 1 0 0.0 0 1 HECTD4
Leg fat mass (right) 2.71 1 0 0.0 0 1 HECTD4
Arm predicted mass (right) 6.33 1 1 3.0 0 1 HECTD4
Comparative height size at age 10 4.97 2 1 3.0 0 1 FES HECTD4
Medication: Aspirin 14.11 2 1 3.0 0 1 FES HECTD4
Hypertension (Self-reported) 34.96 2 2 6.1 0 1 FES HECTD4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 4.73 1 0 0.0 0 1 HECTD4
Illnesses of father: Heart disease 23.15 2 1 3.0 0 1 FES HECTD4
Smoking status: Previous 8.37 1 0 0.0 0 1 HECTD4
Whole body fat-free mass 6.27 2 1 3.0 0 1 FES HECTD4
Leg fat-free mass (right) 5.45 2 1 3.0 0 1 FES HECTD4
Handedness (chirality/laterality): Left-handed 5.04 1 0 0.0 0 1 FES
Loneliness, isolation 4.99 1 0 0.0 0 1 HECTD4
Long-standing illness, disability or infirmity 4.70 1 0 0.0 0 1 HECTD4
Diabetes diagnosed by doctor 3.31 1 0 0.0 0 1 HECTD4
Mouth/teeth dental problems: Mouth ulcers 4.94 1 0 0.0 0 1 HECTD4
Medication for cholesterol 13.98 2 0 0.0 0 1 FES HECTD4
Asthma (self-reported) 3.21 1 0 0.0 0 1 FES
Medication: Aspirin 14.50 1 1 3.0 0 1 FES
Illnesses of father: None of the above (group 1) 21.44 2 1 3.0 0 1 FES HECTD4
Whole body water mass 6.48 2 1 3.0 0 1 FES HECTD4
Leg predicted mass (right) 5.48 2 1 3.0 0 1 FES HECTD4
Arm fat mass (left) 2.86 1 0 0.0 0 1 HECTD4
Number of self-reported non-cancer illnesses 10.28 1 1 3.0 0 1 HECTD4
Medication: Blood pressure 28.11 2 2 6.1 0 1 FES HECTD4
High cholesterol (Self-reported) 4.85 1 0 0.0 0 1 FES
Medication: Bendroflumethiazide 11.87 2 1 3.0 0 1 FES HECTD4
Medication: Lisinopril 10.36 2 0 0.0 0 1 FES HECTD4
Illnesses of father: High blood pressure 20.95 1 1 3.0 0 1 FES
Ever smoked 7.55 2 0 0.0 0 1 FES HECTD4
Basal metabolic rate 6.39 2 1 3.0 0 1 FES HECTD4
Arm fat-free mass (left) 7.17 1 1 3.0 0 1 HECTD4
Risk taking 5.95 1 0 0.0 0 1 FES
Age started oral contraceptive pill 4.45 1 0 0.0 0 1 FES
Diastolic blood pressure, automated reading 33.96 2 2 6.1 0 1 FES HECTD4
Vascular/heart problems diagnosed by doctor 39.56 2 2 6.1 0 1 FES HECTD4
Medication: Omeprazole (e.g. Zanprol) 5.04 1 0 0.0 0 1 HECTD4
Pain experienced in last month 6.28 1 0 0.0 0 1 HECTD4
Heart attack/myocardial infarction (self-reported) 14.91 2 1 3.0 0 1 FES HECTD4
Deep venous thrombosis (DVT) (self-reported) 5.11 1 0 0.0 0 1 HECTD4
Heart disease (siblings) 9.54 1 0 0.0 0 1 FES
Impedance of whole body 3.60 2 1 3.0 0 1 FES HECTD4
Leg fat mass (left) 2.70 1 0 0.0 0 1 HECTD4
Arm predicted mass (left) 6.93 1 1 3.0 0 1 HECTD4

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.25
GTEx Adipose Visceral Omentum 1 0.0491 1.31
GTEx Adrenal Gland 0 0.0000 1.30
GTEx Artery Aorta 0 0.0000 1.33
GTEx Artery Coronary 0 0.0000 1.27
GTEx Artery Tibial 2 0.0532 1.29
GTEx Brain Caudate basal ganglia 0 0.0000 1.24
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.28
GTEx Brain Cerebellum 0 0.0000 1.26
GTEx Brain Cortex 0 0.0000 1.31
GTEx Brain Frontal Cortex BA9 0 0.0000 1.39
GTEx Brain Hippocampus 0 0.0000 1.36
GTEx Brain Hypothalamus 0 0.0000 1.27
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.24
GTEx Brain Putamen basal ganglia 0 0.0000 1.23
GTEx Breast Mammary Tissue 0 0.0000 1.19
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.34
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.25
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.16
GTEx Cells Transformed fibroblasts 1 0.0238 1.26
GTEx Colon Sigmoid 0 0.0000 1.27
GTEx Colon Transverse 0 0.0000 1.27
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.30
GTEx Esophagus Mucosa 0 0.0000 1.25
GTEx Esophagus Muscularis 0 0.0000 1.29
GTEx Heart Atrial Appendage 0 0.0000 1.30
GTEx Heart Left Ventricle 0 0.0000 1.23
GTEx Liver 0 0.0000 1.26
GTEx Lung 1 0.0348 1.28
GTEx Muscle Skeletal 0 0.0000 1.27
GTEx Nerve Tibial 0 0.0000 1.25
GTEx Ovary 0 0.0000 1.21
GTEx Pancreas 0 0.0000 1.29
GTEx Pituitary 0 0.0000 1.33
GTEx Prostate 0 0.0000 1.29
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.27
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.25
GTEx Small Intestine Terminal Ileum 0 0.0000 1.24
GTEx Spleen 0 0.0000 1.27
GTEx Stomach 0 0.0000 1.31
GTEx Testis 0 0.0000 1.26
GTEx Thyroid 1 0.0250 1.30
GTEx Uterus 0 0.0000 1.29
GTEx Vagina 0 0.0000 1.28
GTEx Whole Blood 0 0.0000 1.19
METSIM Adipose 1 0.0217 1.24
NTR Blood 0 0.0000 1.16
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.30
YFS Blood 2 0.0433 1.22
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.28
TCGA Breast Tumor 0 0.0000 1.27
TCGA Breast Normal 1 0.0238 1.20
TCGA Ovarian Tumor 1 0.0342 1.17
TCGA Prostate Tumor 1 0.0289 1.21