Hub : Traits :

High blood pressure (siblings)

35 significantly associated models · 11 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 11181327 12600396 1 1 3.5e-09 5.9e-12 2.2e-04 71 CLCN6
2 6 126271503 127664661 1 1 1.2e-09 5.9e-16 5.6e-08 55 PRELID1P1
3 10 63870456 65606229 2 1 1.6e-09 6.5e-07 9.1e-01 100 NRBF2
4 15 90730363 92135418 1 1 4.2e-09 3.0e-09 2.5e-01 96 FES
5 16 30347731 31833122 6 1 3.5e-08 4.7e-08 1.8e-01 94 KAT8

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in mother) 2.47 1 0 0.0 0.00 1.0e+00 KAT8
Alzheimer’s Disease (including proxy) 3.68 1 0 0.0 0.00 1.0e+00 KAT8
Crohns Disease (2017) 2.05 1 0 0.0 0.00 1.0e+00 FES
Irritable Bowel Disease (IBD) 1.63 1 0 0.0 0.00 1.0e+00 FES
Major Depression (MDD) 2.70 1 0 0.0 0.00 1.0e+00 FES
Breast Cancer 3.06 2 0 0.0 0.00 1.0e+00 FES KAT8
Ovarian Cancer 2.32 1 0 0.0 0.00 1.0e+00 FES
Crohns Disease (2012) 1.69 1 0 0.0 0.00 1.0e+00 FES
HDL Cholesterol 3.00 1 0 0.0 0.00 1.0e+00 NRBF2
Schizophrenia 4.21 1 1 3.0 0.00 1.0e+00 FES
Triglycerides 5.95 2 0 0.0 0.00 1.0e+00 KAT8 NRBF2
Blood Eosinophil Count 0.89 1 0 0.0 0.00 1.0e+00 KAT8
Blood Platelet Count 10.58 2 1 3.0 0.00 1.0e+00 CLCN6 NRBF2
Blood Red Count 2.13 3 2 6.1 0.00 1.0e+00 CLCN6 FES KAT8
Blood White Count 2.78 2 2 6.1 0.00 1.0e+00 FES NRBF2
Heel T-Score 1.42 3 1 3.0 0.00 1.0e+00 KAT8 NRBF2 PRELID1P1
BMI 4.84 3 1 3.0 0.00 1.0e+00 CLCN6 KAT8 NRBF2
Height 0.59 2 1 3.0 0.00 1.0e+00 FES PRELID1P1
Waist Hip Ratio (WHR) 1.92 2 0 0.0 0.00 1.0e+00 CLCN6 PRELID1P1
Systolic Blood Pressure 28.35 4 4 12.1 -0.96 4.1e-02 CLCN6 FES NRBF2 PRELID1P1
Smoking Status 3.70 2 0 0.0 0.00 1.0e+00 FES KAT8
Allergy or Eczema 3.93 3 0 0.0 0.00 1.0e+00 CLCN6 FES NRBF2
Cardiovascular Disease 25.30 5 5 15.2 -0.98 3.5e-03 CLCN6 FES KAT8 NRBF2 PRELID1P1
Respiratory disease 1.82 1 0 0.0 0.00 1.0e+00 FES
Type 2 Diabetes (T2D) 4.75 1 1 3.0 0.00 1.0e+00 PRELID1P1
Lung FEV1/FVC ratio 3.58 1 1 3.0 0.00 1.0e+00 NRBF2
Lung FVC 2.80 3 1 3.0 0.00 1.0e+00 KAT8 NRBF2 PRELID1P1
Neuroticism 2.08 1 0 0.0 0.00 1.0e+00 KAT8
Hair Pigment 0.36 1 1 3.0 0.00 1.0e+00 FES
Tanning 1.10 2 1 3.0 0.00 1.0e+00 CLCN6 NRBF2
Hand grip strength (left) 1.78 1 0 0.0 0.00 1.0e+00 KAT8
Number of treatments/medications taken 3.98 1 0 0.0 0.00 1.0e+00 FES
Sensitivity / hurt feelings 2.26 1 0 0.0 0.00 1.0e+00 FES
Systolic blood pressure, automated reading 21.90 5 4 12.1 0.96 9.9e-03 CLCN6 FES KAT8 NRBF2 PRELID1P1
Angina 6.01 1 1 3.0 0.00 1.0e+00 FES
Impedance of leg (right) 2.74 3 1 3.0 0.00 1.0e+00 FES KAT8 PRELID1P1
Leg fat-free mass (left) 3.45 3 1 3.0 0.00 1.0e+00 FES KAT8 PRELID1P1
Trunk fat percentage 3.80 2 1 3.0 0.00 1.0e+00 CLCN6 KAT8
Townsend deprivation index at recruitment 2.38 1 0 0.0 0.00 1.0e+00 KAT8
High blood pressure 22.91 5 5 15.2 0.97 4.8e-03 CLCN6 FES KAT8 NRBF2 PRELID1P1
Hayfever, allergic rhinitis or eczema 3.45 2 0 0.0 0.00 1.0e+00 CLCN6 NRBF2
Multivitamins +/- minerals 3.31 1 0 0.0 0.00 1.0e+00 NRBF2
Supplements: Glucosamine 4.71 1 1 3.0 0.00 1.0e+00 NRBF2
Medication: Atenolol 9.55 2 1 3.0 0.00 1.0e+00 FES PRELID1P1
Sitting height 1.06 2 0 0.0 0.00 1.0e+00 FES PRELID1P1
High blood pressure (mother) 18.81 4 1 3.0 0.88 1.2e-01 CLCN6 FES NRBF2 PRELID1P1
Body mass index (BMI) 6.06 3 1 3.0 0.00 1.0e+00 CLCN6 KAT8 NRBF2
Impedance of leg (left) 2.64 3 1 3.0 0.00 1.0e+00 FES KAT8 PRELID1P1
Leg predicted mass (left) 3.43 3 1 3.0 0.00 1.0e+00 FES KAT8 PRELID1P1
Trunk fat mass 4.35 2 1 3.0 0.00 1.0e+00 CLCN6 KAT8
Waist circumference 6.22 2 1 3.0 0.00 1.0e+00 KAT8 NRBF2
Number of incorrect matches in round 5.87 1 1 3.0 0.00 1.0e+00 KAT8
Past tobacco smoking 2.25 1 0 0.0 0.00 1.0e+00 KAT8
Alcohol usually taken with meals 2.77 1 0 0.0 0.00 1.0e+00 FES
Nervous feelings 3.36 1 0 0.0 0.00 1.0e+00 KAT8
Had other major operations 4.53 1 0 0.0 0.00 1.0e+00 NRBF2
Forced vital capacity (FVC) 2.36 2 1 3.0 0.00 1.0e+00 KAT8 PRELID1P1
Financial difficulties in last 2 years 2.76 1 0 0.0 0.00 1.0e+00 KAT8
Heart attack 3.48 1 0 0.0 0.00 1.0e+00 FES
Allergy 2.86 2 0 0.0 0.00 1.0e+00 FES NRBF2
Diabetes (self-reported) 3.12 1 0 0.0 0.00 1.0e+00 PRELID1P1
Medication: Ramipril 4.41 1 0 0.0 0.00 1.0e+00 FES
Medication: Simvastatin 6.15 2 0 0.0 0.00 1.0e+00 FES KAT8
Illnesses of siblings 14.89 5 2 6.1 -0.99 1.0e-03 CLCN6 FES KAT8 NRBF2 PRELID1P1
Weight 5.34 3 1 3.0 0.00 1.0e+00 KAT8 NRBF2 PRELID1P1
Impedance of arm (right) 2.96 3 1 3.0 0.00 1.0e+00 KAT8 NRBF2 PRELID1P1
Arm fat percentage (right) 4.83 2 1 3.0 0.00 1.0e+00 CLCN6 KAT8
Trunk fat-free mass 2.93 3 2 6.1 0.00 1.0e+00 KAT8 NRBF2 PRELID1P1
Hip circumference 7.82 4 2 6.1 0.51 4.9e-01 CLCN6 KAT8 NRBF2 PRELID1P1
Father's age at death 5.17 1 0 0.0 0.00 1.0e+00 FES
Worrier / anxious feelings 2.32 1 0 0.0 0.00 1.0e+00 KAT8
Hair/balding pattern: Pattern 3 3.22 1 0 0.0 0.00 1.0e+00 CLCN6
Forced expiratory volume in 1-second (FEV1) 3.57 2 0 0.0 0.00 1.0e+00 KAT8 NRBF2
Medication: Cholesterol lowering 6.62 2 1 3.0 0.00 1.0e+00 FES KAT8
Illnesses of mother 9.54 1 1 3.0 0.00 1.0e+00 FES
Forced expiratory volume in 1-second (FEV1), Best measure 4.55 2 2 6.1 0.00 1.0e+00 KAT8 NRBF2
Impedance of arm (left) 2.88 3 1 3.0 0.00 1.0e+00 KAT8 NRBF2 PRELID1P1
Arm fat mass (right) 5.64 3 1 3.0 0.00 1.0e+00 CLCN6 KAT8 NRBF2
Trunk predicted mass 2.90 3 2 6.1 0.00 1.0e+00 KAT8 NRBF2 PRELID1P1
Standing height 0.53 1 0 0.0 0.00 1.0e+00 PRELID1P1
Breastfed as a baby 2.72 1 0 0.0 0.00 1.0e+00 FES
Tense / 'highly strung' 2.96 1 0 0.0 0.00 1.0e+00 KAT8
Hair/balding pattern: Pattern 4 2.42 1 0 0.0 0.00 1.0e+00 PRELID1P1
Birth weight of first child 8.43 2 1 3.0 0.00 1.0e+00 CLCN6 FES
Headache pain in last month 2.22 1 0 0.0 0.00 1.0e+00 FES
Medication for cholesterol, blood pressure or diabetes 13.08 2 1 3.0 0.00 1.0e+00 CLCN6 FES
Gout (self-reported) 2.94 1 0 0.0 0.00 1.0e+00 NRBF2
Medication: Amlodipine 10.21 3 1 3.0 0.00 1.0e+00 CLCN6 FES PRELID1P1
Medication: Ventolin 100micrograms inhaler 1.86 1 0 0.0 0.00 1.0e+00 NRBF2
Birth weight 5.37 2 1 3.0 0.00 1.0e+00 CLCN6 FES
Forced vital capacity (FVC), Best measure 2.86 3 1 3.0 0.00 1.0e+00 KAT8 NRBF2 PRELID1P1
Body fat percentage 4.49 2 1 3.0 0.00 1.0e+00 CLCN6 KAT8
Leg fat percentage (right) 5.14 3 1 3.0 0.00 1.0e+00 CLCN6 KAT8 NRBF2
Arm fat-free mass (right) 3.81 3 2 6.1 0.00 1.0e+00 KAT8 NRBF2 PRELID1P1
Comparative body size at age 10 2.80 1 0 0.0 0.00 1.0e+00 KAT8
Number of full brothers 2.47 1 0 0.0 0.00 1.0e+00 KAT8
Age at first live birth 2.44 1 0 0.0 0.00 1.0e+00 NRBF2
Qualifications: College or University degree 1.48 1 0 0.0 0.00 1.0e+00 KAT8
Medication: Blood pressure 15.84 3 2 6.1 0.00 1.0e+00 CLCN6 FES PRELID1P1
Angina (self-reported) 5.99 1 1 3.0 0.00 1.0e+00 FES
Mean time to correctly identify matches 1.79 1 0 0.0 0.00 1.0e+00 FES
Heart disease (mother) 2.39 1 0 0.0 0.00 1.0e+00 FES
Whole body fat mass 4.95 2 1 3.0 0.00 1.0e+00 CLCN6 KAT8
Leg fat mass (right) 5.61 3 1 3.0 0.00 1.0e+00 CLCN6 KAT8 NRBF2
Arm predicted mass (right) 3.96 3 2 6.1 0.00 1.0e+00 KAT8 NRBF2 PRELID1P1
Alcohol intake frequency. 2.19 1 0 0.0 0.00 1.0e+00 KAT8
Comparative height size at age 10 2.13 1 1 3.0 0.00 1.0e+00 PRELID1P1
Number of full sisters 5.13 1 0 0.0 0.00 1.0e+00 NRBF2
Overall health rating 4.23 2 1 3.0 0.00 1.0e+00 KAT8 NRBF2
Medication: Aspirin 6.09 1 1 3.0 0.00 1.0e+00 FES
Knee pain experienced in last month 2.86 1 0 0.0 0.00 1.0e+00 KAT8
Hypertension (Self-reported) 22.88 5 5 15.2 0.97 5.2e-03 CLCN6 FES KAT8 NRBF2 PRELID1P1
Illnesses of father: Heart disease 8.01 1 1 3.0 0.00 1.0e+00 FES
Whole body fat-free mass 3.24 3 2 6.1 0.00 1.0e+00 KAT8 NRBF2 PRELID1P1
Leg fat-free mass (right) 3.23 3 1 3.0 0.00 1.0e+00 FES KAT8 PRELID1P1
Arm fat percentage (left) 4.57 2 1 3.0 0.00 1.0e+00 CLCN6 KAT8
Average weekly red wine intake 1.66 1 0 0.0 0.00 1.0e+00 NRBF2
Diabetes diagnosed by doctor 3.25 1 0 0.0 0.00 1.0e+00 PRELID1P1
Medication for cholesterol 9.55 5 0 0.0 -0.99 5.3e-04 CLCN6 FES KAT8 NRBF2 PRELID1P1
Mineral and other dietary supplements 4.24 1 0 0.0 0.00 1.0e+00 NRBF2
Medication: Aspirin 6.55 1 1 3.0 0.00 1.0e+00 FES
Illnesses of father: None of the above (group 1) 8.80 1 1 3.0 0.00 1.0e+00 FES
Forced expiratory volume in 1-second (FEV1), predicted percentage 6.46 2 1 3.0 0.00 1.0e+00 KAT8 NRBF2
Whole body water mass 3.24 3 2 6.1 0.00 1.0e+00 KAT8 NRBF2 PRELID1P1
Leg predicted mass (right) 3.23 3 1 3.0 0.00 1.0e+00 FES KAT8 PRELID1P1
Arm fat mass (left) 5.56 2 1 3.0 0.00 1.0e+00 KAT8 NRBF2
Mother's age at death 2.67 1 0 0.0 0.00 1.0e+00 CLCN6
Medication: Blood pressure 16.01 5 2 6.1 0.99 1.5e-03 CLCN6 FES KAT8 NRBF2 PRELID1P1
High cholesterol (Self-reported) 5.75 2 0 0.0 0.00 1.0e+00 CLCN6 KAT8
Medication: Bendroflumethiazide 10.94 5 0 0.0 1.00 1.7e-05 CLCN6 FES KAT8 NRBF2 PRELID1P1
Medication: Lisinopril 8.17 2 0 0.0 0.00 1.0e+00 NRBF2 PRELID1P1
Medication: Atorvastatin 4.75 1 0 0.0 0.00 1.0e+00 KAT8
Illnesses of father: High blood pressure 13.28 1 1 3.0 0.00 1.0e+00 FES
Basal metabolic rate 3.79 3 2 6.1 0.00 1.0e+00 KAT8 NRBF2 PRELID1P1
Leg fat percentage (left) 5.19 3 1 3.0 0.00 1.0e+00 CLCN6 KAT8 NRBF2
Arm fat-free mass (left) 4.22 3 2 6.1 0.00 1.0e+00 KAT8 NRBF2 PRELID1P1
Number of operations (self-reported) 2.83 1 0 0.0 0.00 1.0e+00 NRBF2
Fractured/broken bones in last 5 years 3.27 1 0 0.0 0.00 1.0e+00 KAT8
Diastolic blood pressure, automated reading 22.67 5 5 15.2 0.96 8.8e-03 CLCN6 FES KAT8 NRBF2 PRELID1P1
Unable to work because of sickness or disability 1.80 1 0 0.0 0.00 1.0e+00 KAT8
Vascular/heart problems diagnosed by doctor 24.92 5 5 15.2 -0.97 4.9e-03 CLCN6 FES KAT8 NRBF2 PRELID1P1
Cholesterol lowering medication 5.34 1 0 0.0 0.00 1.0e+00 KAT8
Pain experienced in last month 2.56 1 0 0.0 0.00 1.0e+00 KAT8
Heart attack/myocardial infarction (self-reported) 3.74 1 0 0.0 0.00 1.0e+00 FES
Heart disease (siblings) 5.91 1 0 0.0 0.00 1.0e+00 FES
Impedance of whole body 2.85 3 1 3.0 0.00 1.0e+00 KAT8 NRBF2 PRELID1P1
Leg fat mass (left) 5.57 3 1 3.0 0.00 1.0e+00 CLCN6 KAT8 NRBF2
Arm predicted mass (left) 4.24 3 1 3.0 0.00 1.0e+00 KAT8 NRBF2 PRELID1P1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.49
GTEx Adipose Visceral Omentum 2 0.0982 1.44
GTEx Adrenal Gland 0 0.0000 1.52
GTEx Artery Aorta 1 0.0336 1.53
GTEx Artery Coronary 1 0.0845 1.57
GTEx Artery Tibial 1 0.0266 1.45
GTEx Brain Caudate basal ganglia 0 0.0000 1.56
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.52
GTEx Brain Cerebellum 1 0.0505 1.48
GTEx Brain Cortex 1 0.0966 1.71
GTEx Brain Frontal Cortex BA9 1 0.1082 1.59
GTEx Brain Hippocampus 0 0.0000 1.67
GTEx Brain Hypothalamus 0 0.0000 1.56
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.61
GTEx Brain Putamen basal ganglia 0 0.0000 1.59
GTEx Breast Mammary Tissue 0 0.0000 1.44
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.49
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.46
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.42
GTEx Cells Transformed fibroblasts 2 0.0476 1.46
GTEx Colon Sigmoid 0 0.0000 1.47
GTEx Colon Transverse 0 0.0000 1.51
GTEx Esophagus Gastroesophageal Junction 1 0.0692 1.51
GTEx Esophagus Mucosa 0 0.0000 1.45
GTEx Esophagus Muscularis 0 0.0000 1.49
GTEx Heart Atrial Appendage 1 0.0633 1.45
GTEx Heart Left Ventricle 0 0.0000 1.50
GTEx Liver 1 0.1395 1.52
GTEx Lung 1 0.0348 1.51
GTEx Muscle Skeletal 0 0.0000 1.50
GTEx Nerve Tibial 0 0.0000 1.47
GTEx Ovary 1 0.1101 1.61
GTEx Pancreas 0 0.0000 1.46
GTEx Pituitary 0 0.0000 1.50
GTEx Prostate 0 0.0000 1.55
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.50
GTEx Skin Sun Exposed Lower leg 2 0.0549 1.44
GTEx Small Intestine Terminal Ileum 0 0.0000 1.54
GTEx Spleen 0 0.0000 1.43
GTEx Stomach 0 0.0000 1.60
GTEx Testis 0 0.0000 1.52
GTEx Thyroid 1 0.0250 1.51
GTEx Uterus 0 0.0000 1.64
GTEx Vagina 0 0.0000 1.49
GTEx Whole Blood 2 0.1004 1.50
METSIM Adipose 1 0.0217 1.42
NTR Blood 1 0.0416 1.36
ROSMAP Brain Pre-frontal Cortex 3 0.0683 1.50
YFS Blood 2 0.0433 1.37
CommonMind Brain Pre-frontal Cortex 2 0.0372 1.38
TCGA Breast Tumor 0 0.0000 1.41
TCGA Breast Normal 1 0.0238 1.44
TCGA Ovarian Tumor 2 0.0684 1.34
TCGA Prostate Tumor 1 0.0289 1.45