Hub : Traits :

Illnesses of siblings: Diabetes

3 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 10 11693166 13569805 1 1 2.2e-07 7.2e-06 1e+00 100 CAMK1D
2 10 114018656 115622375 1 1 4.8e-12 7.2e-34 3e-24 30 TCF7L2
3 19 18333894 19729194 1 1 1.1e-07 5.6e-07 1e+00 100 DDX49

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Verbal and Numeric Reasoning (VNR) 1.09 1 0 0.0 0 1 TCF7L2
Breast Cancer 10.56 2 1 3.0 0 1 DDX49 TCF7L2
Age at First Birth 2.59 1 0 0.0 0 1 DDX49
Body Mass Index (BMI) (2010) 3.75 1 0 0.0 0 1 TCF7L2
Coronary Artery Disease (CAD) 3.97 2 0 0.0 0 1 CAMK1D DDX49
Fasting Glucose 9.23 3 0 0.0 0 1 CAMK1D DDX49 TCF7L2
LDL Cholesterol 6.79 1 1 3.0 0 1 DDX49
Schizophrenia 2.63 2 0 0.0 0 1 CAMK1D DDX49
Triglycerides 8.85 1 1 3.0 0 1 DDX49
Type 2 Diabetes (T2D) 14.54 3 1 3.0 0 1 CAMK1D DDX49 TCF7L2
Blood Eosinophil Count 0.29 1 0 0.0 0 1 DDX49
Blood Platelet Count 1.56 2 1 3.0 0 1 DDX49 TCF7L2
Blood Red Count 0.49 2 0 0.0 0 1 DDX49 TCF7L2
Heel T-Score 2.08 2 1 3.0 0 1 DDX49 TCF7L2
BMI 3.30 2 1 3.0 0 1 DDX49 TCF7L2
Height 3.12 2 1 3.0 0 1 DDX49 TCF7L2
Waist Hip Ratio (WHR) 5.87 1 1 3.0 0 1 TCF7L2
Systolic Blood Pressure 3.56 2 1 3.0 0 1 CAMK1D TCF7L2
Cardiovascular Disease 1.25 1 0 0.0 0 1 CAMK1D
Type 2 Diabetes (T2D) 60.91 3 2 6.1 0 1 CAMK1D DDX49 TCF7L2
Lung FEV1/FVC ratio 11.68 2 1 3.0 0 1 CAMK1D DDX49
Lung FVC 3.14 1 1 3.0 0 1 CAMK1D
Chronotype (morning person) 2.86 3 0 0.0 0 1 CAMK1D DDX49 TCF7L2
Hair Pigment 0.13 1 0 0.0 0 1 DDX49
Number of treatments/medications taken 3.84 1 0 0.0 0 1 DDX49
Average weekly spirits intake 3.60 1 0 0.0 0 1 DDX49
Sensitivity / hurt feelings 2.36 1 0 0.0 0 1 DDX49
Systolic blood pressure, automated reading 3.80 1 1 3.0 0 1 CAMK1D
Eye problems/disorders: Diabetes related eye disease 9.57 2 0 0.0 0 1 DDX49 TCF7L2
Medication: Metformin 41.05 3 2 6.1 0 1 CAMK1D DDX49 TCF7L2
Diabetes (father) 32.08 1 1 3.0 0 1 TCF7L2
Diabetes (mother) 34.72 3 2 6.1 0 1 CAMK1D DDX49 TCF7L2
Impedance of leg (right) 1.43 2 0 0.0 0 1 DDX49 TCF7L2
Leg fat-free mass (left) 2.34 2 0 0.0 0 1 DDX49 TCF7L2
Trunk fat percentage 1.07 1 0 0.0 0 1 TCF7L2
Hand grip strength (right) 1.28 1 0 0.0 0 1 TCF7L2
Maternal smoking around birth 4.17 1 0 0.0 0 1 DDX49
Fed-up feelings 2.72 1 0 0.0 0 1 DDX49
Taking other prescription medications 4.72 1 0 0.0 0 1 DDX49
Heel bone mineral density (BMD) T-score, automated (left) 2.15 2 0 0.0 0 1 DDX49 TCF7L2
High blood pressure 1.64 1 0 0.0 0 1 CAMK1D
Stomach or abdominal pain in last month 4.88 1 0 0.0 0 1 DDX49
Supplements: Glucosamine 2.00 1 0 0.0 0 1 DDX49
Sitting height 1.41 1 1 3.0 0 1 DDX49
Body mass index (BMI) 3.85 2 1 3.0 0 1 DDX49 TCF7L2
Impedance of leg (left) 1.46 2 0 0.0 0 1 DDX49 TCF7L2
Leg predicted mass (left) 2.34 2 0 0.0 0 1 DDX49 TCF7L2
Trunk fat mass 1.41 1 0 0.0 0 1 TCF7L2
Waist circumference 2.06 1 0 0.0 0 1 TCF7L2
Alcohol usually taken with meals 2.17 1 0 0.0 0 1 TCF7L2
Hair/balding pattern: Pattern 2 2.43 1 0 0.0 0 1 DDX49
Forced vital capacity (FVC) 3.22 2 0 0.0 0 1 CAMK1D DDX49
Heel bone mineral density (BMD) T-score, automated (right) 1.88 1 0 0.0 0 1 TCF7L2
Qualifications: None of the above 3.11 1 0 0.0 0 1 DDX49
Mouth/teeth dental problems 3.02 1 0 0.0 0 1 DDX49
Pain all over the body in last month 2.91 1 0 0.0 0 1 DDX49
Diabetes (self-reported) 41.31 3 1 3.0 0 1 CAMK1D DDX49 TCF7L2
Medication: Ramipril 3.33 1 0 0.0 0 1 CAMK1D
Medication: Simvastatin 8.46 3 0 0.0 0 1 CAMK1D DDX49 TCF7L2
Weight 1.76 1 0 0.0 0 1 TCF7L2
Impedance of arm (right) 3.20 2 1 3.0 0 1 DDX49 TCF7L2
Arm fat percentage (right) 2.06 1 0 0.0 0 1 TCF7L2
Trunk fat-free mass 1.62 1 0 0.0 0 1 DDX49
Hip circumference 4.85 1 1 3.0 0 1 TCF7L2
Worrier / anxious feelings 2.71 1 0 0.0 0 1 TCF7L2
Frequency of tiredness / lethargy in last 2 weeks 1.80 1 0 0.0 0 1 DDX49
Number of live births 2.85 1 0 0.0 0 1 DDX49
Forced expiratory volume in 1-second (FEV1) 6.27 1 1 3.0 0 1 CAMK1D
Pulse rate 2.43 1 0 0.0 0 1 CAMK1D
Qualifications: A levels/AS levels or equivalent 2.89 1 0 0.0 0 1 DDX49
Serious illness, injury or assault of a close relative in last 2 years 2.89 1 0 0.0 0 1 DDX49
Medication: Cholesterol lowering 8.17 3 0 0.0 0 1 CAMK1D DDX49 TCF7L2
Medication: Lansoprazole 2.73 1 0 0.0 0 1 DDX49
Illnesses of mother 2.49 1 0 0.0 0 1 TCF7L2
Forced expiratory volume in 1-second (FEV1), Best measure 6.62 2 1 3.0 0 1 CAMK1D DDX49
Impedance of arm (left) 3.19 2 1 3.0 0 1 DDX49 TCF7L2
Arm fat mass (right) 2.25 1 1 3.0 0 1 TCF7L2
Trunk predicted mass 1.62 2 0 0.0 0 1 DDX49 TCF7L2
Standing height 4.11 2 1 3.0 0 1 DDX49 TCF7L2
Birth weight of first child 3.73 2 0 0.0 0 1 DDX49 TCF7L2
Peak expiratory flow (PEF) 4.52 1 1 3.0 0 1 CAMK1D
Medication: Paracetamol 3.92 1 0 0.0 0 1 DDX49
Medication for cholesterol, blood pressure or diabetes 5.56 2 0 0.0 0 1 CAMK1D TCF7L2
Birth weight 3.47 2 0 0.0 0 1 DDX49 TCF7L2
Forced vital capacity (FVC), Best measure 3.78 2 0 0.0 0 1 CAMK1D DDX49
Body fat percentage 2.54 2 0 0.0 0 1 DDX49 TCF7L2
Leg fat percentage (right) 6.94 2 2 6.1 0 1 DDX49 TCF7L2
Arm fat-free mass (right) 0.94 1 0 0.0 0 1 TCF7L2
Age at first live birth 5.53 1 1 3.0 0 1 DDX49
Qualifications: College or University degree 2.09 1 0 0.0 0 1 DDX49
Medication for pain relief, constipation, heartburn 2.54 1 0 0.0 0 1 DDX49
Medication: Blood pressure 3.47 1 0 0.0 0 1 CAMK1D
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.79 1 0 0.0 0 1 TCF7L2
Whole body fat mass 2.19 1 0 0.0 0 1 TCF7L2
Leg fat mass (right) 4.06 2 1 3.0 0 1 DDX49 TCF7L2
Arm predicted mass (right) 0.83 1 0 0.0 0 1 TCF7L2
Pulse rate, automated reading 1.18 1 0 0.0 0 1 TCF7L2
Comparative height size at age 10 3.23 1 1 3.0 0 1 DDX49
Overall health rating 3.81 2 0 0.0 0 1 CAMK1D DDX49
Age at last live birth 2.41 1 0 0.0 0 1 DDX49
Qualifications: NVQ or HND or HNC or equivalent 3.10 1 0 0.0 0 1 DDX49
Hypertension (Self-reported) 1.70 1 0 0.0 0 1 CAMK1D
Illnesses of father: Heart disease 3.73 2 0 0.0 0 1 CAMK1D DDX49
Forced expiratory volume in 1-second (FEV1), predicted 2.70 2 0 0.0 0 1 DDX49 TCF7L2
Whole body fat-free mass 1.87 2 0 0.0 0 1 DDX49 TCF7L2
Leg fat-free mass (right) 2.46 2 1 3.0 0 1 DDX49 TCF7L2
Arm fat percentage (left) 2.13 1 0 0.0 0 1 TCF7L2
Handedness (chirality/laterality): Left-handed 2.11 1 0 0.0 0 1 DDX49
Loneliness, isolation 2.73 1 0 0.0 0 1 DDX49
Long-standing illness, disability or infirmity 3.72 1 0 0.0 0 1 CAMK1D
Diabetes diagnosed by doctor 49.19 3 2 6.1 0 1 CAMK1D DDX49 TCF7L2
Ever had stillbirth, spontaneous miscarriage or termination 3.95 1 0 0.0 0 1 TCF7L2
Qualifications: nursing, teaching 5.23 2 0 0.0 0 1 DDX49 TCF7L2
Mouth/teeth dental problems: Mouth ulcers 2.36 1 0 0.0 0 1 DDX49
Breast cancer (self-reported) 3.50 1 0 0.0 0 1 TCF7L2
Osteoarthritis (self-reported) 1.72 1 0 0.0 0 1 DDX49
Medication: Aspirin 3.91 1 0 0.0 0 1 TCF7L2
Medication: Gliclazide 24.84 3 1 3.0 0 1 CAMK1D DDX49 TCF7L2
Illnesses of father: None of the above (group 1) 7.16 3 0 0.0 0 1 CAMK1D DDX49 TCF7L2
Forced expiratory volume in 1-second (FEV1), predicted percentage 5.20 1 1 3.0 0 1 CAMK1D
Whole body water mass 1.82 2 0 0.0 0 1 DDX49 TCF7L2
Leg predicted mass (right) 2.48 2 1 3.0 0 1 DDX49 TCF7L2
Arm fat mass (left) 2.08 1 0 0.0 0 1 TCF7L2
Number of self-reported non-cancer illnesses 2.08 1 0 0.0 0 1 DDX49
Average weekly champagne plus white wine intake 3.86 2 0 0.0 0 1 DDX49 TCF7L2
High cholesterol (Self-reported) 7.88 2 1 3.0 0 1 DDX49 TCF7L2
Medication: Paracetamol 2.27 1 0 0.0 0 1 DDX49
Medication: Atorvastatin 7.07 1 0 0.0 0 1 TCF7L2
Illnesses of father: High blood pressure 2.28 1 0 0.0 0 1 CAMK1D
Basal metabolic rate 1.75 2 0 0.0 0 1 DDX49 TCF7L2
Leg fat percentage (left) 7.25 2 2 6.1 0 1 DDX49 TCF7L2
Arm fat-free mass (left) 1.12 1 0 0.0 0 1 TCF7L2
Diastolic blood pressure, automated reading 2.28 2 0 0.0 0 1 DDX49 TCF7L2
Unable to work because of sickness or disability 2.06 1 0 0.0 0 1 DDX49
Myopia 1.94 1 0 0.0 0 1 TCF7L2
Vascular/heart problems diagnosed by doctor 1.59 1 0 0.0 0 1 CAMK1D
Cholesterol lowering medication 6.87 1 0 0.0 0 1 TCF7L2
Impedance of whole body 1.02 1 0 0.0 0 1 TCF7L2
Leg fat mass (left) 4.11 2 1 3.0 0 1 DDX49 TCF7L2
Arm predicted mass (left) 0.98 1 0 0.0 0 1 TCF7L2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.27
GTEx Adipose Visceral Omentum 0 0.0000 1.35
GTEx Adrenal Gland 0 0.0000 1.24
GTEx Artery Aorta 1 0.0336 1.28
GTEx Artery Coronary 0 0.0000 1.23
GTEx Artery Tibial 0 0.0000 1.25
GTEx Brain Caudate basal ganglia 0 0.0000 1.31
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.25
GTEx Brain Cerebellum 0 0.0000 1.24
GTEx Brain Cortex 0 0.0000 1.25
GTEx Brain Frontal Cortex BA9 0 0.0000 1.34
GTEx Brain Hippocampus 1 0.1908 1.32
GTEx Brain Hypothalamus 0 0.0000 1.27
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.32
GTEx Brain Putamen basal ganglia 0 0.0000 1.33
GTEx Breast Mammary Tissue 0 0.0000 1.28
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.20
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.26
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.24
GTEx Cells Transformed fibroblasts 0 0.0000 1.27
GTEx Colon Sigmoid 0 0.0000 1.23
GTEx Colon Transverse 0 0.0000 1.23
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.22
GTEx Esophagus Mucosa 0 0.0000 1.25
GTEx Esophagus Muscularis 0 0.0000 1.27
GTEx Heart Atrial Appendage 0 0.0000 1.29
GTEx Heart Left Ventricle 0 0.0000 1.24
GTEx Liver 0 0.0000 1.30
GTEx Lung 1 0.0348 1.24
GTEx Muscle Skeletal 0 0.0000 1.26
GTEx Nerve Tibial 0 0.0000 1.27
GTEx Ovary 0 0.0000 1.37
GTEx Pancreas 0 0.0000 1.28
GTEx Pituitary 0 0.0000 1.30
GTEx Prostate 0 0.0000 1.25
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.25
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.23
GTEx Small Intestine Terminal Ileum 0 0.0000 1.37
GTEx Spleen 0 0.0000 1.28
GTEx Stomach 0 0.0000 1.30
GTEx Testis 0 0.0000 1.22
GTEx Thyroid 0 0.0000 1.26
GTEx Uterus 0 0.0000 1.28
GTEx Vagina 0 0.0000 1.12
GTEx Whole Blood 0 0.0000 1.29
METSIM Adipose 0 0.0000 1.23
NTR Blood 0 0.0000 1.23
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.25
YFS Blood 0 0.0000 1.22
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.19
TCGA Breast Tumor 0 0.0000 1.18
TCGA Breast Normal 0 0.0000 1.19
TCGA Ovarian Tumor 0 0.0000 1.16
TCGA Prostate Tumor 0 0.0000 1.22