Hub : Traits :

Neuroticism

354 significantly associated models · 54 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 8 8092025 13120332 34 1 1.3e-16 4.2e-16 0.032 93 AF131215.9
2 11 9105636 11027552 2 1 6.5e-08 4.1e-08 0.023 83 ADM
3 11 46686260 48559571 5 1 4.2e-08 2.3e-07 0.039 84 MTCH2
4 17 42774693 45285474 13 1 1.9e-10 4.4e-10 1.000 100 KANSL1-AS1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 4.24 1 0 0.0 0.00 1.0000 MTCH2
Verbal and Numeric Reasoning (VNR) 4.66 2 0 0.0 0.00 1.0000 KANSL1-AS1 MTCH2
Breast Cancer 6.14 1 1 3.0 0.00 1.0000 KANSL1-AS1
Ovarian Cancer 8.80 1 1 3.0 0.00 1.0000 KANSL1-AS1
Body Mass Index (BMI) (2010) 7.35 1 1 3.0 0.00 1.0000 MTCH2
Crohns Disease (2012) 3.19 1 0 0.0 0.00 1.0000 KANSL1-AS1
HDL Cholesterol 3.87 1 0 0.0 0.00 1.0000 MTCH2
Lupus 6.75 1 1 3.0 0.00 1.0000 AF131215.9
Primary Biliary Cirrhosis 4.03 1 0 0.0 0.00 1.0000 KANSL1-AS1
Triglycerides 2.81 1 0 0.0 0.00 1.0000 AF131215.9
Blood Eosinophil Count 4.58 1 1 3.0 0.00 1.0000 KANSL1-AS1
Blood Platelet Count 1.85 2 2 6.1 0.00 1.0000 KANSL1-AS1 MTCH2
Blood Red Count 15.14 3 3 9.1 0.00 1.0000 ADM KANSL1-AS1 MTCH2
Blood White Count 4.19 2 2 6.1 0.00 1.0000 KANSL1-AS1 MTCH2
Heel T-Score 3.83 1 1 3.0 0.00 1.0000 KANSL1-AS1
BMI 5.78 1 1 3.0 0.00 1.0000 MTCH2
Height 3.62 3 3 9.1 0.00 1.0000 ADM KANSL1-AS1 MTCH2
Waist Hip Ratio (WHR) 9.36 2 2 6.1 0.00 1.0000 ADM KANSL1-AS1
Systolic Blood Pressure 8.73 3 2 6.1 0.00 1.0000 ADM KANSL1-AS1 MTCH2
Hypothyroidism (self reported) 3.30 1 0 0.0 0.00 1.0000 MTCH2
Lung FEV1/FVC ratio 2.53 2 1 3.0 0.00 1.0000 ADM KANSL1-AS1
Lung FVC 11.61 1 1 3.0 0.00 1.0000 KANSL1-AS1
Neuroticism 18.83 3 2 6.1 0.00 1.0000 ADM KANSL1-AS1 MTCH2
Hair Pigment 0.52 2 1 3.0 0.00 1.0000 ADM KANSL1-AS1
Tanning 0.82 1 0 0.0 0.00 1.0000 MTCH2
Hand grip strength (left) 8.64 2 2 6.1 0.00 1.0000 KANSL1-AS1 MTCH2
Sensitivity / hurt feelings 19.71 2 2 6.1 0.00 1.0000 AF131215.9 KANSL1-AS1
Frequency of depressed mood in last 2 weeks 9.59 2 0 0.0 0.00 1.0000 KANSL1-AS1 MTCH2
Relative age of first facial hair 14.54 1 1 3.0 0.00 1.0000 KANSL1-AS1
Ever used hormone-replacement therapy (HRT) 3.75 1 0 0.0 0.00 1.0000 MTCH2
Systolic blood pressure, automated reading 8.02 3 2 6.1 0.00 1.0000 ADM AF131215.9 KANSL1-AS1
Vitamin and mineral supplements 4.52 1 0 0.0 0.00 1.0000 KANSL1-AS1
Medication: Metformin 4.10 1 0 0.0 0.00 1.0000 MTCH2
Impedance of leg (right) 8.98 4 3 9.1 -0.69 0.3134 ADM AF131215.9 KANSL1-AS1 MTCH2
Leg fat-free mass (left) 3.10 2 1 3.0 0.00 1.0000 ADM AF131215.9
Trunk fat percentage 10.24 3 2 6.1 0.00 1.0000 ADM KANSL1-AS1 MTCH2
Hand grip strength (right) 6.33 2 1 3.0 0.00 1.0000 KANSL1-AS1 MTCH2
Townsend deprivation index at recruitment 3.90 1 0 0.0 0.00 1.0000 MTCH2
Current tobacco smoking 7.09 2 0 0.0 0.00 1.0000 AF131215.9 MTCH2
Fed-up feelings 12.28 3 2 6.1 0.00 1.0000 AF131215.9 KANSL1-AS1 MTCH2
Relative age voice broke 9.51 1 1 3.0 0.00 1.0000 KANSL1-AS1
Age when periods started (menarche) 5.35 2 1 3.0 0.00 1.0000 KANSL1-AS1 MTCH2
Heel bone mineral density (BMD) T-score, automated (left) 10.95 2 1 3.0 0.00 1.0000 AF131215.9 KANSL1-AS1
High blood pressure 6.96 1 1 3.0 0.00 1.0000 AF131215.9
Medication: Levothyroxine sodium 5.26 1 0 0.0 0.00 1.0000 AF131215.9
Sitting height 8.47 3 3 9.1 0.00 1.0000 ADM KANSL1-AS1 MTCH2
Body mass index (BMI) 8.97 2 2 6.1 0.00 1.0000 AF131215.9 MTCH2
Impedance of leg (left) 9.13 4 2 6.1 -0.66 0.3411 ADM AF131215.9 KANSL1-AS1 MTCH2
Leg predicted mass (left) 3.10 2 1 3.0 0.00 1.0000 ADM AF131215.9
Trunk fat mass 6.21 3 1 3.0 0.00 1.0000 AF131215.9 KANSL1-AS1 MTCH2
Waist circumference 4.90 1 1 3.0 0.00 1.0000 MTCH2
Nervous feelings 18.95 4 2 6.1 -1.00 0.0036 ADM AF131215.9 KANSL1-AS1 MTCH2
Frequency of tenseness / restlessness in last 2 weeks 11.06 2 1 3.0 0.00 1.0000 KANSL1-AS1 MTCH2
Hearing difficulty/problems with background noise 4.76 1 0 0.0 0.00 1.0000 KANSL1-AS1
Hair/balding pattern: Pattern 2 6.41 1 0 0.0 0.00 1.0000 KANSL1-AS1
Forced vital capacity (FVC) 10.77 2 1 3.0 0.00 1.0000 KANSL1-AS1 MTCH2
Heel bone mineral density (BMD) T-score, automated (right) 10.91 2 1 3.0 0.00 1.0000 AF131215.9 KANSL1-AS1
Ever unenthusiastic/disinterested for a whole week 3.97 1 0 0.0 0.00 1.0000 KANSL1-AS1
Mouth/teeth dental problems 4.45 1 0 0.0 0.00 1.0000 KANSL1-AS1
Fluid intelligence score 5.42 1 0 0.0 0.00 1.0000 MTCH2
Neuroticism score 28.84 4 3 9.1 -0.99 0.0107 ADM AF131215.9 KANSL1-AS1 MTCH2
Weight 2.82 2 1 3.0 0.00 1.0000 AF131215.9 MTCH2
Impedance of arm (right) 10.35 3 3 9.1 0.00 1.0000 ADM AF131215.9 KANSL1-AS1
Arm fat percentage (right) 10.91 3 1 3.0 0.00 1.0000 ADM AF131215.9 MTCH2
Trunk fat-free mass 4.57 3 1 3.0 0.00 1.0000 ADM AF131215.9 MTCH2
Hip circumference 5.05 2 2 6.1 0.00 1.0000 AF131215.9 MTCH2
Time employed in main current job 5.34 1 0 0.0 0.00 1.0000 KANSL1-AS1
Worrier / anxious feelings 18.63 2 2 6.1 0.00 1.0000 AF131215.9 KANSL1-AS1
Hair/balding pattern: Pattern 3 14.00 1 1 3.0 0.00 1.0000 KANSL1-AS1
Number of live births 3.43 1 0 0.0 0.00 1.0000 KANSL1-AS1
Forced expiratory volume in 1-second (FEV1) 11.60 2 1 3.0 0.00 1.0000 KANSL1-AS1 MTCH2
Qualifications: A levels/AS levels or equivalent 3.24 1 0 0.0 0.00 1.0000 KANSL1-AS1
Serious illness, injury or assault of a close relative in last 2 years 4.93 1 0 0.0 0.00 1.0000 AF131215.9
Mouth/teeth dental problems: Dentures 2.99 1 0 0.0 0.00 1.0000 AF131215.9
Medication: Ibuprofen (e.g. Nurofen) 4.95 1 0 0.0 0.00 1.0000 KANSL1-AS1
Forced expiratory volume in 1-second (FEV1), Best measure 11.30 2 1 3.0 0.00 1.0000 KANSL1-AS1 MTCH2
Impedance of arm (left) 10.33 3 3 9.1 0.00 1.0000 ADM AF131215.9 KANSL1-AS1
Arm fat mass (right) 7.14 2 2 6.1 0.00 1.0000 AF131215.9 MTCH2
Trunk predicted mass 4.51 3 1 3.0 0.00 1.0000 ADM AF131215.9 MTCH2
Standing height 4.25 4 3 9.1 -0.16 0.8384 ADM AF131215.9 KANSL1-AS1 MTCH2
Tense / 'highly strung' 10.20 1 1 3.0 0.00 1.0000 AF131215.9
Hair/balding pattern: Pattern 4 24.93 1 1 3.0 0.00 1.0000 KANSL1-AS1
Peak expiratory flow (PEF) 9.67 2 1 3.0 0.00 1.0000 AF131215.9 KANSL1-AS1
Medication: Paracetamol 9.88 1 1 3.0 0.00 1.0000 KANSL1-AS1
Headache pain in last month 11.04 1 1 3.0 0.00 1.0000 KANSL1-AS1
Hypothyroidism/myxoedema (self-reported) 6.01 1 1 3.0 0.00 1.0000 AF131215.9
Birth weight 4.07 2 0 0.0 0.00 1.0000 ADM MTCH2
Forced vital capacity (FVC), Best measure 11.47 2 2 6.1 0.00 1.0000 KANSL1-AS1 MTCH2
Body fat percentage 9.64 2 2 6.1 0.00 1.0000 ADM MTCH2
Leg fat percentage (right) 7.67 3 1 3.0 0.00 1.0000 ADM AF131215.9 MTCH2
Arm fat-free mass (right) 4.02 2 2 6.1 0.00 1.0000 ADM AF131215.9
Comparative body size at age 10 10.45 2 2 6.1 0.00 1.0000 AF131215.9 MTCH2
Worry too long after embarrassment 12.62 2 1 3.0 0.00 1.0000 AF131215.9 KANSL1-AS1
Qualifications: College or University degree 3.67 1 1 3.0 0.00 1.0000 KANSL1-AS1
Medication for pain relief, constipation, heartburn 5.29 1 1 3.0 0.00 1.0000 KANSL1-AS1
Medication: Ibuprofen 4.55 1 0 0.0 0.00 1.0000 KANSL1-AS1
Whole body fat mass 6.00 2 1 3.0 0.00 1.0000 AF131215.9 MTCH2
Leg fat mass (right) 6.07 2 2 6.1 0.00 1.0000 AF131215.9 MTCH2
Arm predicted mass (right) 3.99 2 2 6.1 0.00 1.0000 ADM AF131215.9
Alcohol intake frequency. 8.37 2 2 6.1 0.00 1.0000 KANSL1-AS1 MTCH2
Comparative height size at age 10 2.09 1 1 3.0 0.00 1.0000 KANSL1-AS1
Suffer from 'nerves' 18.04 3 2 6.1 0.00 1.0000 AF131215.9 KANSL1-AS1 MTCH2
Overall health rating 2.87 1 0 0.0 0.00 1.0000 AF131215.9
Leg pain on walking 4.20 1 0 0.0 0.00 1.0000 KANSL1-AS1
Hypertension (Self-reported) 6.72 1 1 3.0 0.00 1.0000 AF131215.9
Whole body fat-free mass 3.67 2 2 6.1 0.00 1.0000 ADM AF131215.9
Leg fat-free mass (right) 3.20 2 2 6.1 0.00 1.0000 ADM AF131215.9
Arm fat percentage (left) 11.75 3 2 6.1 0.00 1.0000 ADM AF131215.9 MTCH2
Handedness (chirality/laterality): Left-handed 6.71 1 1 3.0 0.00 1.0000 KANSL1-AS1
Mood swings 17.50 3 3 9.1 0.00 1.0000 AF131215.9 KANSL1-AS1 MTCH2
Loneliness, isolation 11.65 2 1 3.0 0.00 1.0000 KANSL1-AS1 MTCH2
Mouth/teeth dental problems: Mouth ulcers 8.28 1 1 3.0 0.00 1.0000 KANSL1-AS1
Smoking status: Current 7.67 2 0 0.0 0.00 1.0000 AF131215.9 MTCH2
Forced expiratory volume in 1-second (FEV1), predicted percentage 9.90 1 1 3.0 0.00 1.0000 KANSL1-AS1
Whole body water mass 3.77 2 2 6.1 0.00 1.0000 ADM AF131215.9
Leg predicted mass (right) 3.13 2 2 6.1 0.00 1.0000 ADM AF131215.9
Arm fat mass (left) 7.32 2 2 6.1 0.00 1.0000 AF131215.9 MTCH2
Average weekly champagne plus white wine intake 5.38 1 0 0.0 0.00 1.0000 KANSL1-AS1
Miserableness 17.38 3 3 9.1 0.00 1.0000 AF131215.9 KANSL1-AS1 MTCH2
Guilty feelings 13.46 3 2 6.1 0.00 1.0000 AF131215.9 KANSL1-AS1 MTCH2
Medication: Blood pressure 8.19 2 1 3.0 0.00 1.0000 AF131215.9 KANSL1-AS1
Medication: Bendroflumethiazide 6.73 1 0 0.0 0.00 1.0000 AF131215.9
Medication: Paracetamol 10.03 1 1 3.0 0.00 1.0000 KANSL1-AS1
Basal metabolic rate 3.00 2 2 6.1 0.00 1.0000 ADM AF131215.9
Leg fat percentage (left) 8.17 3 1 3.0 0.00 1.0000 ADM AF131215.9 MTCH2
Arm fat-free mass (left) 3.79 2 2 6.1 0.00 1.0000 ADM AF131215.9
Average weekly beer plus cider intake 7.03 1 0 0.0 0.00 1.0000 AF131215.9
Irritability 15.54 2 2 6.1 0.00 1.0000 AF131215.9 KANSL1-AS1
Risk taking 4.46 1 0 0.0 0.00 1.0000 AF131215.9
Diastolic blood pressure, automated reading 6.87 2 1 3.0 0.00 1.0000 ADM AF131215.9
Vascular/heart problems diagnosed by doctor 4.85 1 1 3.0 0.00 1.0000 AF131215.9
Pain experienced in last month 3.48 1 0 0.0 0.00 1.0000 KANSL1-AS1
Impedance of whole body 10.83 3 3 9.1 0.00 1.0000 ADM AF131215.9 KANSL1-AS1
Leg fat mass (left) 6.33 2 2 6.1 0.00 1.0000 AF131215.9 MTCH2
Arm predicted mass (left) 3.89 2 2 6.1 0.00 1.0000 ADM AF131215.9

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 8 0.2297 1.44
GTEx Adipose Visceral Omentum 8 0.3935 1.51
GTEx Adrenal Gland 5 0.3441 1.49
GTEx Artery Aorta 10 0.3362 1.50
GTEx Artery Coronary 7 0.5947 1.61
GTEx Artery Tibial 8 0.2132 1.47
GTEx Brain Caudate basal ganglia 4 0.4353 1.57
GTEx Brain Cerebellar Hemisphere 6 0.4035 1.56
GTEx Brain Cerebellum 5 0.2525 1.45
GTEx Brain Cortex 7 0.6783 1.70
GTEx Brain Frontal Cortex BA9 5 0.5429 1.62
GTEx Brain Hippocampus 3 0.5714 1.66
GTEx Brain Hypothalamus 3 0.5076 1.56
GTEx Brain Nucleus accumbens basal ganglia 4 0.4619 1.51
GTEx Brain Putamen basal ganglia 3 0.4808 1.59
GTEx Breast Mammary Tissue 9 0.4564 1.48
GTEx Breast Mammary Tissue (Male) 7 0.5917 1.63
GTEx Breast Mammary Tissue (Female) 6 0.3667 1.45
GTEx Cells EBV-transformed lymphocytes 8 0.5634 1.72
GTEx Cells Transformed fibroblasts 8 0.1909 1.41
GTEx Colon Sigmoid 9 0.6164 1.53
GTEx Colon Transverse 10 0.4850 1.47
GTEx Esophagus Gastroesophageal Junction 7 0.4854 1.62
GTEx Esophagus Mucosa 9 0.2713 1.44
GTEx Esophagus Muscularis 12 0.3720 1.57
GTEx Heart Atrial Appendage 6 0.3800 1.57
GTEx Heart Left Ventricle 7 0.4584 1.57
GTEx Liver 3 0.4213 1.58
GTEx Lung 10 0.3487 1.53
GTEx Muscle Skeletal 8 0.2772 1.49
GTEx Nerve Tibial 8 0.1853 1.44
GTEx Ovary 4 0.4405 1.53
GTEx Pancreas 7 0.4289 1.55
GTEx Pituitary 4 0.3587 1.48
GTEx Prostate 4 0.4808 1.56
GTEx Skin Not Sun Exposed Suprapubic 10 0.4065 1.62
GTEx Skin Sun Exposed Lower leg 11 0.3031 1.49
GTEx Small Intestine Terminal Ileum 5 1.0870 1.66
GTEx Spleen 6 0.4261 1.62
GTEx Stomach 6 0.4127 1.46
GTEx Testis 12 0.3810 1.55
GTEx Thyroid 11 0.2757 1.50
GTEx Uterus 8 1.4134 1.78
GTEx Vagina 4 0.6319 1.48
GTEx Whole Blood 5 0.2518 1.47
METSIM Adipose 1 0.0217 1.33
NTR Blood 6 0.2498 1.48
ROSMAP Brain Pre-frontal Cortex 16 0.3653 1.54
YFS Blood 1 0.0217 1.34
CommonMind Brain Pre-frontal Cortex 8 0.1489 1.45
TCGA Breast Tumor 1 0.1311 1.44
TCGA Breast Normal 0 0.0000 1.27
TCGA Ovarian Tumor 8 0.2746 1.40
TCGA Prostate Tumor 3 0.0869 1.34