Hub : Traits :

Ovarian Cancer

389 significantly associated models · 38 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 176358042 177746117 1 1 1.5e-07 3.5e-14 1.9e-08 45 HOXD1
2 3 155768424 157456920 2 2 1.2e-14 1.1e-38 6.8e-24 40 LEKR1 LINC00886
3 8 81946437 83365154 1 1 6.6e-10 1.3e-09 1.0e+00 100 CHMP4C
4 10 21087485 22724472 2 1 4.5e-09 4.9e-10 3.7e-02 89 MLLT10
5 15 90800449 92187978 1 1 6.6e-08 8.4e-08 2.0e-01 94 RCCD1
6 17 42774693 47357969 28 2 2.5e-14 9.3e-14 2.5e-03 84 HOXB-AS1 PLEKHM1
7 19 16643043 18117646 3 2 1.8e-10 8.1e-17 2.1e-06 68 ABHD8 ANKLE1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Ulcerative Colitis (UC) 1.79 1 0 0.0 0.00 1.00 CHMP4C
Verbal and Numeric Reasoning (VNR) 1.75 1 0 0.0 0.00 1.00 PLEKHM1
Breast Cancer 8.06 5 4 12.1 0.64 0.25 ABHD8 ANKLE1 MLLT10 PLEKHM1 RCCD1
Neuroticism 3.14 1 1 3.0 0.00 1.00 PLEKHM1
Primary Biliary Cirrhosis 1.92 1 0 0.0 0.00 1.00 PLEKHM1
Blood Eosinophil Count 1.52 1 1 3.0 0.00 1.00 PLEKHM1
Blood Platelet Count 1.67 3 2 6.1 0.00 1.00 HOXB-AS1 PLEKHM1 RCCD1
Blood Red Count 5.88 3 3 9.1 0.00 1.00 HOXB-AS1 HOXD1 PLEKHM1
Blood White Count 1.01 1 1 3.0 0.00 1.00 PLEKHM1
Heel T-Score 6.03 5 3 9.1 0.54 0.35 ANKLE1 CHMP4C LEKR1 LINC00886 PLEKHM1
BMI 2.10 1 1 3.0 0.00 1.00 MLLT10
Height 0.85 3 2 6.1 0.00 1.00 ANKLE1 LEKR1 PLEKHM1
Waist Hip Ratio (WHR) 2.46 1 1 3.0 0.00 1.00 PLEKHM1
Systolic Blood Pressure 1.59 2 2 6.1 0.00 1.00 HOXB-AS1 PLEKHM1
Smoking Status 2.02 1 1 3.0 0.00 1.00 MLLT10
Cardiovascular Disease 0.79 1 0 0.0 0.00 1.00 MLLT10
Type 2 Diabetes (T2D) 2.59 1 0 0.0 0.00 1.00 LEKR1
Lung FEV1/FVC ratio 1.82 3 1 3.0 0.00 1.00 LINC00886 MLLT10 PLEKHM1
Lung FVC 5.84 3 3 9.1 0.00 1.00 HOXB-AS1 MLLT10 PLEKHM1
Neuroticism 5.34 1 1 3.0 0.00 1.00 PLEKHM1
Hair Pigment 0.35 3 1 3.0 0.00 1.00 ABHD8 HOXB-AS1 PLEKHM1
Tanning 0.42 1 0 0.0 0.00 1.00 LEKR1
Hand grip strength (left) 3.19 3 1 3.0 0.00 1.00 HOXB-AS1 MLLT10 PLEKHM1
Number of treatments/medications taken 2.80 1 1 3.0 0.00 1.00 MLLT10
Sensitivity / hurt feelings 5.42 1 1 3.0 0.00 1.00 PLEKHM1
Frequency of depressed mood in last 2 weeks 1.83 1 0 0.0 0.00 1.00 PLEKHM1
Hearing difficulty/problems: Yes 3.03 1 0 0.0 0.00 1.00 CHMP4C
Relative age of first facial hair 5.70 1 1 3.0 0.00 1.00 PLEKHM1
Ever had hysterectomy (womb removed) 2.63 1 0 0.0 0.00 1.00 MLLT10
Systolic blood pressure, automated reading 2.15 1 0 0.0 0.00 1.00 PLEKHM1
Impedance of leg (right) 1.12 1 0 0.0 0.00 1.00 PLEKHM1
Leg fat-free mass (left) 0.66 1 0 0.0 0.00 1.00 MLLT10
Trunk fat percentage 2.30 2 1 3.0 0.00 1.00 MLLT10 PLEKHM1
Hand grip strength (right) 3.03 3 1 3.0 0.00 1.00 HOXB-AS1 MLLT10 PLEKHM1
Maternal smoking around birth 2.09 1 0 0.0 0.00 1.00 MLLT10
Fed-up feelings 2.59 1 1 3.0 0.00 1.00 PLEKHM1
Relative age voice broke 4.36 1 1 3.0 0.00 1.00 PLEKHM1
Age when periods started (menarche) 0.94 1 0 0.0 0.00 1.00 PLEKHM1
Bilateral oophorectomy (both ovaries removed) 2.81 1 0 0.0 0.00 1.00 MLLT10
Heel bone mineral density (BMD) T-score, automated (left) 4.33 2 1 3.0 0.00 1.00 LEKR1 LINC00886
High blood pressure 1.64 1 0 0.0 0.00 1.00 MLLT10
Sitting height 1.99 2 1 3.0 0.00 1.00 MLLT10 PLEKHM1
Body mass index (BMI) 2.15 1 1 3.0 0.00 1.00 MLLT10
Impedance of leg (left) 1.13 1 0 0.0 0.00 1.00 PLEKHM1
Leg predicted mass (left) 0.65 1 0 0.0 0.00 1.00 MLLT10
Trunk fat mass 1.99 2 1 3.0 0.00 1.00 MLLT10 PLEKHM1
Waist circumference 2.69 1 1 3.0 0.00 1.00 MLLT10
Past tobacco smoking 2.35 1 0 0.0 0.00 1.00 MLLT10
Nervous feelings 2.49 1 1 3.0 0.00 1.00 PLEKHM1
Frequency of tenseness / restlessness in last 2 weeks 2.97 1 1 3.0 0.00 1.00 PLEKHM1
Hearing difficulty/problems with background noise 2.88 2 0 0.0 0.00 1.00 CHMP4C PLEKHM1
Hair/balding pattern: Pattern 2 1.98 1 0 0.0 0.00 1.00 PLEKHM1
Forced vital capacity (FVC) 4.91 3 1 3.0 0.00 1.00 HOXB-AS1 MLLT10 PLEKHM1
Heel bone mineral density (BMD) T-score, automated (right) 4.03 2 1 3.0 0.00 1.00 LEKR1 LINC00886
Ever unenthusiastic/disinterested for a whole week 2.57 1 0 0.0 0.00 1.00 PLEKHM1
Fluid intelligence score 1.29 1 0 0.0 0.00 1.00 PLEKHM1
Neuroticism score 4.31 1 1 3.0 0.00 1.00 PLEKHM1
Weight 1.34 1 1 3.0 0.00 1.00 MLLT10
Impedance of arm (right) 2.57 4 1 3.0 -0.49 0.51 ANKLE1 HOXD1 MLLT10 PLEKHM1
Arm fat percentage (right) 1.64 1 1 3.0 0.00 1.00 MLLT10
Trunk fat-free mass 0.72 1 0 0.0 0.00 1.00 ANKLE1
Hip circumference 1.94 1 1 3.0 0.00 1.00 MLLT10
Worrier / anxious feelings 2.10 1 1 3.0 0.00 1.00 PLEKHM1
Hair/balding pattern: Pattern 3 5.19 1 1 3.0 0.00 1.00 PLEKHM1
Number of live births 2.22 1 0 0.0 0.00 1.00 PLEKHM1
Forced expiratory volume in 1-second (FEV1) 4.73 2 1 3.0 0.00 1.00 HOXB-AS1 PLEKHM1
Qualifications: A levels/AS levels or equivalent 2.06 1 0 0.0 0.00 1.00 PLEKHM1
Asthma 1.79 1 0 0.0 0.00 1.00 MLLT10
Medication: Ibuprofen (e.g. Nurofen) 2.77 1 0 0.0 0.00 1.00 PLEKHM1
Forced expiratory volume in 1-second (FEV1), Best measure 4.98 2 1 3.0 0.00 1.00 HOXB-AS1 PLEKHM1
Impedance of arm (left) 2.82 4 2 6.1 -0.46 0.54 ANKLE1 HOXD1 MLLT10 PLEKHM1
Arm fat mass (right) 1.67 1 1 3.0 0.00 1.00 MLLT10
Trunk predicted mass 0.72 1 0 0.0 0.00 1.00 ANKLE1
Standing height 0.68 1 1 3.0 0.00 1.00 PLEKHM1
Hair/balding pattern: Pattern 4 10.34 2 1 3.0 0.00 1.00 HOXD1 PLEKHM1
Peak expiratory flow (PEF) 3.76 2 1 3.0 0.00 1.00 MLLT10 PLEKHM1
Medication: Paracetamol 5.27 2 1 3.0 0.00 1.00 MLLT10 PLEKHM1
Headache pain in last month 4.32 1 1 3.0 0.00 1.00 PLEKHM1
Forced vital capacity (FVC), Best measure 5.37 3 2 6.1 0.00 1.00 HOXB-AS1 MLLT10 PLEKHM1
Body fat percentage 2.23 1 1 3.0 0.00 1.00 MLLT10
Leg fat percentage (right) 2.80 1 1 3.0 0.00 1.00 MLLT10
Arm fat-free mass (right) 0.99 2 0 0.0 0.00 1.00 ANKLE1 MLLT10
Worry too long after embarrassment 3.10 1 0 0.0 0.00 1.00 PLEKHM1
Qualifications: College or University degree 2.27 2 1 3.0 0.00 1.00 MLLT10 PLEKHM1
Medication for pain relief, constipation, heartburn 3.52 2 1 3.0 0.00 1.00 MLLT10 PLEKHM1
Medication: Ibuprofen 2.76 1 0 0.0 0.00 1.00 PLEKHM1
Whole body fat mass 1.99 1 1 3.0 0.00 1.00 MLLT10
Leg fat mass (right) 2.48 1 1 3.0 0.00 1.00 MLLT10
Arm predicted mass (right) 1.01 1 1 3.0 0.00 1.00 MLLT10
Pulse rate, automated reading 1.70 2 0 0.0 0.00 1.00 ANKLE1 LEKR1
Alcohol intake frequency. 1.90 1 1 3.0 0.00 1.00 PLEKHM1
Comparative height size at age 10 0.91 1 1 3.0 0.00 1.00 PLEKHM1
Suffer from 'nerves' 1.79 1 0 0.0 0.00 1.00 PLEKHM1
Overall health rating 1.39 1 0 0.0 0.00 1.00 MLLT10
Hypertension (Self-reported) 1.55 1 0 0.0 0.00 1.00 MLLT10
Smoking status: Previous 2.43 1 0 0.0 0.00 1.00 MLLT10
Whole body fat-free mass 0.69 1 0 0.0 0.00 1.00 ANKLE1
Arm fat percentage (left) 1.84 1 1 3.0 0.00 1.00 MLLT10
Handedness (chirality/laterality): Left-handed 2.55 1 0 0.0 0.00 1.00 PLEKHM1
Mood swings 3.47 1 1 3.0 0.00 1.00 PLEKHM1
Loneliness, isolation 1.51 1 0 0.0 0.00 1.00 PLEKHM1
Ever had bowel cancer screening 2.76 1 0 0.0 0.00 1.00 MLLT10
Diabetes diagnosed by doctor 2.31 1 0 0.0 0.00 1.00 RCCD1
Mouth/teeth dental problems: Mouth ulcers 2.90 1 1 3.0 0.00 1.00 PLEKHM1
Breast cancer (self-reported) 3.35 1 0 0.0 0.00 1.00 MLLT10
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.29 1 1 3.0 0.00 1.00 PLEKHM1
Whole body water mass 0.70 1 0 0.0 0.00 1.00 ANKLE1
Arm fat mass (left) 1.75 1 1 3.0 0.00 1.00 MLLT10
Number of self-reported non-cancer illnesses 1.56 1 0 0.0 0.00 1.00 MLLT10
Average weekly champagne plus white wine intake 2.80 1 0 0.0 0.00 1.00 PLEKHM1
Miserableness 2.08 1 1 3.0 0.00 1.00 PLEKHM1
Guilty feelings 1.70 1 0 0.0 0.00 1.00 PLEKHM1
Medication: Blood pressure 2.48 1 1 3.0 0.00 1.00 PLEKHM1
Medication: Paracetamol 5.43 2 1 3.0 0.00 1.00 MLLT10 PLEKHM1
Basal metabolic rate 0.78 2 0 0.0 0.00 1.00 ANKLE1 MLLT10
Leg fat percentage (left) 2.64 1 1 3.0 0.00 1.00 MLLT10
Arm fat-free mass (left) 1.06 2 0 0.0 0.00 1.00 ANKLE1 MLLT10
Number of operations (self-reported) 3.13 1 0 0.0 0.00 1.00 MLLT10
Irritability 2.53 1 1 3.0 0.00 1.00 PLEKHM1
Diastolic blood pressure, automated reading 1.53 1 1 3.0 0.00 1.00 MLLT10
Vascular/heart problems diagnosed by doctor 1.71 1 1 3.0 0.00 1.00 MLLT10
Pain experienced in last month 2.68 1 0 0.0 0.00 1.00 PLEKHM1
Impedance of whole body 2.16 2 1 3.0 0.00 1.00 ANKLE1 PLEKHM1
Leg fat mass (left) 2.38 1 1 3.0 0.00 1.00 MLLT10
Arm predicted mass (left) 1.03 2 0 0.0 0.00 1.00 ANKLE1 MLLT10

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 10 0.2863 1.35
GTEx Adipose Visceral Omentum 7 0.3433 1.39
GTEx Adrenal Gland 6 0.4115 1.41
GTEx Artery Aorta 11 0.3691 1.37
GTEx Artery Coronary 9 0.7595 1.53
GTEx Artery Tibial 5 0.1329 1.27
GTEx Brain Caudate basal ganglia 5 0.5423 1.48
GTEx Brain Cerebellar Hemisphere 8 0.5369 1.41
GTEx Brain Cerebellum 8 0.4032 1.35
GTEx Brain Cortex 7 0.6757 1.63
GTEx Brain Frontal Cortex BA9 8 0.8639 1.63
GTEx Brain Hippocampus 5 0.9506 1.61
GTEx Brain Hypothalamus 5 0.8460 1.53
GTEx Brain Nucleus accumbens basal ganglia 7 0.8083 1.56
GTEx Brain Putamen basal ganglia 5 0.8000 1.55
GTEx Breast Mammary Tissue 8 0.4049 1.37
GTEx Breast Mammary Tissue (Male) 8 0.6700 1.48
GTEx Breast Mammary Tissue (Female) 8 0.4860 1.38
GTEx Cells EBV-transformed lymphocytes 9 0.6325 1.59
GTEx Cells Transformed fibroblasts 11 0.2618 1.36
GTEx Colon Sigmoid 7 0.4785 1.49
GTEx Colon Transverse 9 0.4354 1.40
GTEx Esophagus Gastroesophageal Junction 9 0.6220 1.46
GTEx Esophagus Mucosa 13 0.3913 1.35
GTEx Esophagus Muscularis 11 0.3401 1.36
GTEx Heart Atrial Appendage 7 0.4428 1.35
GTEx Heart Left Ventricle 7 0.4566 1.41
GTEx Liver 4 0.5571 1.48
GTEx Lung 12 0.4172 1.35
GTEx Muscle Skeletal 13 0.4494 1.34
GTEx Nerve Tibial 10 0.2312 1.34
GTEx Ovary 6 0.6593 1.47
GTEx Pancreas 8 0.4899 1.43
GTEx Pituitary 5 0.4480 1.36
GTEx Prostate 4 0.4790 1.36
GTEx Skin Not Sun Exposed Suprapubic 10 0.4062 1.38
GTEx Skin Sun Exposed Lower leg 12 0.3297 1.34
GTEx Small Intestine Terminal Ileum 4 0.8658 1.75
GTEx Spleen 9 0.6374 1.49
GTEx Stomach 7 0.4808 1.38
GTEx Testis 11 0.3484 1.41
GTEx Thyroid 14 0.3499 1.35
GTEx Uterus 6 1.0563 1.65
GTEx Vagina 6 0.9434 1.56
GTEx Whole Blood 6 0.3011 1.33
METSIM Adipose 2 0.0434 1.22
NTR Blood 4 0.1664 1.31
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.14
YFS Blood 0 0.0000 1.18
CommonMind Brain Pre-frontal Cortex 2 0.0372 1.20
TCGA Breast Tumor 3 0.3911 1.28
TCGA Breast Normal 6 0.1426 1.24
TCGA Ovarian Tumor 3 0.1026 1.18
TCGA Prostate Tumor 9 0.2602 1.28