Hub : Traits :

Worry too long after embarrassment

155 significantly associated models · 44 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 135273949 137261517 2 1 1.2e-09 9.6e-10 1.0e+00 100 PCCB
2 5 106500969 108412472 1 1 1.8e-08 6.7e-08 7.8e-02 89 FBXL17
3 5 138933151 140378983 1 1 2.6e-07 7.7e-08 2.1e-02 82 PFDN1
4 8 8092025 11891593 19 1 5.4e-13 3.8e-13 1.9e-02 90 XKR6
5 9 127218258 128824378 3 1 8.3e-10 3.7e-09 1.0e-01 92 PRPS1P2
6 11 12611333 14105497 1 1 5.7e-18 1.8e-21 4.8e-05 82 ARNTL
7 11 56716782 58178587 3 1 1.8e-10 7.8e-11 2.7e-02 88 ZDHHC5
8 11 112486568 113952419 1 1 5.9e-08 4.0e-11 1.5e-04 67 TTC12
9 12 109133588 110578192 1 1 2.9e-08 1.5e-06 1.7e-01 92 MYO1H
10 13 110849169 112251122 1 1 2.0e-07 7.1e-07 2.4e-01 94 ANKRD10-IT1
11 15 66850204 68492262 1 1 3.0e-07 4.1e-06 2.4e-01 94 IQCH
12 16 89375239 90172696 4 1 1.2e-09 4.1e-07 9.5e-01 100 DBNDD1
13 17 1584324 3000009 3 1 2.1e-08 2.2e-07 9.5e-01 100 MNT
14 19 13505333 14978284 2 1 1.3e-07 1.3e-07 1.0e+00 100 PRKACA

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Major Depression (MDD) 3.67 1 0 0.0 0.00 1.0e+00 ZDHHC5
Reaction Time 2.09 1 0 0.0 0.00 1.0e+00 PFDN1
Verbal and Numeric Reasoning (VNR) 2.26 2 1 3.0 0.00 1.0e+00 PFDN1 ZDHHC5
Body Mass Index (BMI) (2010) 2.90 2 0 0.0 0.00 1.0e+00 DBNDD1 IQCH
HDL Cholesterol 2.77 1 1 3.0 0.00 1.0e+00 MYO1H
Lupus 1.80 1 0 0.0 0.00 1.0e+00 XKR6
Neuroticism 8.20 4 1 3.0 -0.96 4.5e-02 ARNTL MNT PCCB XKR6
Schizophrenia 3.05 3 1 3.0 0.00 1.0e+00 PCCB TTC12 ZDHHC5
Blood Eosinophil Count 1.20 3 2 6.1 0.00 1.0e+00 FBXL17 IQCH MYO1H
Blood Platelet Count 1.17 3 3 9.1 0.00 1.0e+00 MNT PCCB ZDHHC5
Blood Red Count 0.94 4 2 6.1 -0.90 1.0e-01 ANKRD10-IT1 ARNTL MNT ZDHHC5
Blood White Count 0.99 4 0 0.0 0.31 6.9e-01 MYO1H PCCB PRPS1P2 TTC12
Heel T-Score 1.22 4 1 3.0 -0.16 8.4e-01 DBNDD1 IQCH MNT ZDHHC5
BMI 2.20 4 2 6.1 0.75 2.5e-01 ARNTL IQCH PFDN1 TTC12
Height 0.92 4 2 6.1 1.00 4.1e-03 DBNDD1 IQCH PCCB PRKACA
Waist Hip Ratio (WHR) 1.55 4 1 3.0 -0.24 7.6e-01 IQCH PCCB PRPS1P2 TTC12
Systolic Blood Pressure 2.22 3 3 9.1 0.00 1.0e+00 ARNTL PRPS1P2 ZDHHC5
Smoking Status 2.96 2 1 3.0 0.00 1.0e+00 IQCH PRPS1P2
Cardiovascular Disease 2.08 4 0 0.0 0.72 2.8e-01 ARNTL IQCH PCCB TTC12
Respiratory disease 2.87 1 1 3.0 0.00 1.0e+00 IQCH
Lung FEV1/FVC ratio 0.69 1 0 0.0 0.00 1.0e+00 ZDHHC5
Lung FVC 1.50 2 1 3.0 0.00 1.0e+00 IQCH PFDN1
Neuroticism 11.28 11 7 21.2 -0.98 5.0e-08 ANKRD10-IT1 ARNTL FBXL17 IQCH MNT MYO1H PCCB PFDN1 PRPS1P2 TTC12 ZDHHC5
Hair Pigment 94.75 1 1 3.0 0.00 1.0e+00 DBNDD1
Tanning 85.47 2 1 3.0 0.00 1.0e+00 DBNDD1 PFDN1
Hand grip strength (left) 1.47 1 0 0.0 0.00 1.0e+00 PRKACA
Number of treatments/medications taken 1.87 1 0 0.0 0.00 1.0e+00 TTC12
Sensitivity / hurt feelings 8.62 7 2 6.1 0.98 7.4e-05 IQCH MYO1H PCCB PRPS1P2 TTC12 XKR6 ZDHHC5
Frequency of depressed mood in last 2 weeks 4.25 2 0 0.0 0.00 1.0e+00 PCCB ZDHHC5
Hearing difficulty/problems: Yes 4.18 2 0 0.0 0.00 1.0e+00 FBXL17 MYO1H
Relative age of first facial hair 3.21 1 1 3.0 0.00 1.0e+00 DBNDD1
Other serious medical condition/disability diagnosed by doctor 2.66 2 0 0.0 0.00 1.0e+00 ANKRD10-IT1 TTC12
Systolic blood pressure, automated reading 2.99 4 1 3.0 -0.98 1.8e-02 ARNTL PRPS1P2 XKR6 ZDHHC5
Pack years adult smoking proportion 2.31 1 0 0.0 0.00 1.0e+00 MNT
Impedance of leg (right) 2.92 4 3 9.1 0.53 4.7e-01 DBNDD1 MNT PRPS1P2 XKR6
Leg fat-free mass (left) 1.72 3 2 6.1 0.00 1.0e+00 IQCH PRPS1P2 XKR6
Trunk fat percentage 3.43 5 1 3.0 -0.15 8.1e-01 ARNTL IQCH MNT TTC12 ZDHHC5
Townsend deprivation index at recruitment 2.02 1 0 0.0 0.00 1.0e+00 IQCH
Current tobacco smoking 2.80 2 0 0.0 0.00 1.0e+00 PRPS1P2 XKR6
Maternal smoking around birth 2.21 1 0 0.0 0.00 1.0e+00 MYO1H
Fed-up feelings 6.07 6 2 6.1 0.99 1.3e-04 ANKRD10-IT1 ARNTL PCCB TTC12 XKR6 ZDHHC5
Frequency of unenthusiasm / disinterest in last 2 weeks 4.55 3 0 0.0 0.00 1.0e+00 PCCB TTC12 ZDHHC5
Relative age voice broke 2.45 2 0 0.0 0.00 1.0e+00 DBNDD1 PCCB
Taking other prescription medications 2.24 1 0 0.0 0.00 1.0e+00 IQCH
Age when periods started (menarche) 2.71 2 1 3.0 0.00 1.0e+00 ARNTL IQCH
Heel bone mineral density (BMD) T-score, automated (left) 3.55 2 1 3.0 0.00 1.0e+00 DBNDD1 XKR6
High blood pressure 3.61 4 1 3.0 -0.81 1.9e-01 ARNTL DBNDD1 IQCH XKR6
Stomach or abdominal pain in last month 1.92 1 0 0.0 0.00 1.0e+00 PCCB
Medication: Levothyroxine sodium 1.33 1 0 0.0 0.00 1.0e+00 XKR6
Sitting height 1.15 4 1 3.0 -1.00 2.4e-03 DBNDD1 PRKACA PRPS1P2 ZDHHC5
Chronic bronchitis/emphysema (father) 2.50 1 0 0.0 0.00 1.0e+00 IQCH
Body mass index (BMI) 2.92 3 3 9.1 0.00 1.0e+00 ARNTL IQCH XKR6
Impedance of leg (left) 2.90 4 3 9.1 0.57 4.3e-01 DBNDD1 MNT PRPS1P2 XKR6
Leg predicted mass (left) 1.75 3 2 6.1 0.00 1.0e+00 IQCH PRPS1P2 XKR6
Trunk fat mass 3.14 5 1 3.0 -0.63 2.5e-01 ARNTL IQCH TTC12 XKR6 ZDHHC5
Waist circumference 2.80 3 1 3.0 0.00 1.0e+00 ARNTL IQCH TTC12
Past tobacco smoking 3.65 3 1 3.0 0.00 1.0e+00 ANKRD10-IT1 IQCH PRPS1P2
Alcohol usually taken with meals 4.92 2 1 3.0 0.00 1.0e+00 MNT ZDHHC5
Nervous feelings 10.24 8 2 6.1 0.97 9.7e-05 ANKRD10-IT1 ARNTL IQCH MYO1H PCCB PRPS1P2 TTC12 XKR6
Frequency of tenseness / restlessness in last 2 weeks 4.51 1 1 3.0 0.00 1.0e+00 PCCB
Forced vital capacity (FVC) 1.34 2 0 0.0 0.00 1.0e+00 DBNDD1 IQCH
Heel bone mineral density (BMD) T-score, automated (right) 3.54 2 1 3.0 0.00 1.0e+00 DBNDD1 XKR6
Qualifications: None of the above 1.67 1 0 0.0 0.00 1.0e+00 ZDHHC5
Mouth/teeth dental problems 2.46 1 0 0.0 0.00 1.0e+00 MYO1H
Allergy 1.62 1 0 0.0 0.00 1.0e+00 IQCH
Fluid intelligence score 2.10 2 0 0.0 0.00 1.0e+00 PCCB PFDN1
Neuroticism score 14.06 11 7 21.2 0.98 3.5e-07 ANKRD10-IT1 ARNTL FBXL17 IQCH MNT MYO1H PCCB PRPS1P2 TTC12 XKR6 ZDHHC5
Weight 2.20 5 2 6.1 -0.79 1.1e-01 ARNTL IQCH PRPS1P2 TTC12 XKR6
Impedance of arm (right) 2.33 4 1 3.0 0.76 2.4e-01 DBNDD1 PRPS1P2 XKR6 ZDHHC5
Arm fat percentage (right) 3.62 6 4 12.1 -0.26 6.2e-01 ARNTL IQCH PRKACA TTC12 XKR6 ZDHHC5
Trunk fat-free mass 1.25 2 1 3.0 0.00 1.0e+00 PRPS1P2 XKR6
Hip circumference 2.35 4 2 6.1 -0.38 6.2e-01 IQCH PRPS1P2 TTC12 XKR6
Father's age at death 1.60 1 0 0.0 0.00 1.0e+00 XKR6
Worrier / anxious feelings 10.38 7 3 9.1 0.96 5.7e-04 ARNTL FBXL17 MYO1H PCCB PRPS1P2 XKR6 ZDHHC5
Frequency of tiredness / lethargy in last 2 weeks 5.62 4 2 6.1 0.99 1.4e-02 MNT MYO1H PCCB ZDHHC5
Number of live births 1.24 1 0 0.0 0.00 1.0e+00 DBNDD1
Forced expiratory volume in 1-second (FEV1) 1.34 2 0 0.0 0.00 1.0e+00 DBNDD1 PRPS1P2
Serious illness, injury or assault of a close relative in last 2 years 2.65 1 0 0.0 0.00 1.0e+00 XKR6
Asthma 2.07 1 0 0.0 0.00 1.0e+00 IQCH
Impedance of arm (left) 2.01 4 1 3.0 0.73 2.7e-01 DBNDD1 PRPS1P2 XKR6 ZDHHC5
Arm fat mass (right) 3.21 5 3 9.1 -0.73 1.6e-01 ARNTL IQCH TTC12 XKR6 ZDHHC5
Trunk predicted mass 1.26 2 1 3.0 0.00 1.0e+00 PRPS1P2 XKR6
Standing height 1.06 2 1 3.0 0.00 1.0e+00 DBNDD1 PRKACA
Tense / 'highly strung' 6.40 5 1 3.0 0.99 5.3e-04 FBXL17 PCCB TTC12 XKR6 ZDHHC5
Seen doctor (GP) for nerves, anxiety, tension or depression 2.92 2 0 0.0 0.00 1.0e+00 TTC12 ZDHHC5
Hair/balding pattern: Pattern 4 1.71 2 0 0.0 0.00 1.0e+00 DBNDD1 IQCH
Peak expiratory flow (PEF) 2.06 2 0 0.0 0.00 1.0e+00 PRPS1P2 XKR6
Mouth/teeth dental problems: Bleeding gums 1.83 1 0 0.0 0.00 1.0e+00 MYO1H
Medication: Paracetamol 2.35 1 0 0.0 0.00 1.0e+00 PFDN1
Headache pain in last month 3.04 1 0 0.0 0.00 1.0e+00 ZDHHC5
Hypothyroidism/myxoedema (self-reported) 1.84 1 1 3.0 0.00 1.0e+00 XKR6
Forced vital capacity (FVC), Best measure 0.95 1 0 0.0 0.00 1.0e+00 DBNDD1
Body fat percentage 3.54 6 1 3.0 -0.20 7.1e-01 ARNTL IQCH MNT TTC12 XKR6 ZDHHC5
Leg fat percentage (right) 3.11 5 1 3.0 -0.32 6.0e-01 ARNTL IQCH MNT TTC12 XKR6
Arm fat-free mass (right) 1.47 2 2 6.1 0.00 1.0e+00 PRPS1P2 XKR6
Exposure to tobacco smoke outside home 1.75 1 0 0.0 0.00 1.0e+00 PRKACA
Comparative body size at age 10 3.39 3 1 3.0 0.00 1.0e+00 IQCH PRKACA XKR6
Age at first live birth 1.75 1 0 0.0 0.00 1.0e+00 XKR6
Qualifications: College or University degree 1.94 3 1 3.0 0.00 1.0e+00 MNT PFDN1 ZDHHC5
Medication: Blood pressure 1.85 1 0 0.0 0.00 1.0e+00 XKR6
Mean time to correctly identify matches 2.34 1 1 3.0 0.00 1.0e+00 PFDN1
Whole body fat mass 3.18 4 1 3.0 -0.75 2.5e-01 ARNTL IQCH TTC12 XKR6
Leg fat mass (right) 3.19 4 2 6.1 -0.79 2.1e-01 ARNTL IQCH TTC12 XKR6
Arm predicted mass (right) 1.49 2 2 6.1 0.00 1.0e+00 PRPS1P2 XKR6
Pulse rate, automated reading 1.72 2 0 0.0 0.00 1.0e+00 ARNTL ZDHHC5
Alcohol intake frequency. 1.60 1 0 0.0 0.00 1.0e+00 ZDHHC5
Comparative height size at age 10 1.12 4 0 0.0 -0.63 3.7e-01 DBNDD1 IQCH PCCB TTC12
Suffer from 'nerves' 6.16 4 2 6.1 0.99 7.6e-03 FBXL17 IQCH TTC12 XKR6
Overall health rating 3.36 3 2 6.1 0.00 1.0e+00 MNT TTC12 XKR6
Hypertension (Self-reported) 3.52 4 1 3.0 -0.81 1.9e-01 ARNTL DBNDD1 IQCH XKR6
Smoking status: Previous 2.88 1 0 0.0 0.00 1.0e+00 IQCH
Whole body fat-free mass 1.40 3 2 6.1 0.00 1.0e+00 IQCH PRPS1P2 XKR6
Leg fat-free mass (right) 1.68 3 2 6.1 0.00 1.0e+00 IQCH PRPS1P2 XKR6
Arm fat percentage (left) 3.55 5 3 9.1 -0.66 2.2e-01 ARNTL IQCH TTC12 XKR6 ZDHHC5
Average weekly red wine intake 2.98 2 1 3.0 0.00 1.0e+00 MNT ZDHHC5
Mood swings 4.96 3 1 3.0 0.00 1.0e+00 TTC12 XKR6 ZDHHC5
Loneliness, isolation 3.46 1 0 0.0 0.00 1.0e+00 ARNTL
Long-standing illness, disability or infirmity 2.40 2 0 0.0 0.00 1.0e+00 IQCH TTC12
Medication for cholesterol 1.92 1 0 0.0 0.00 1.0e+00 XKR6
Asthma (self-reported) 2.20 1 1 3.0 0.00 1.0e+00 IQCH
Smoking status: Current 3.00 2 0 0.0 0.00 1.0e+00 PRPS1P2 XKR6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.63 1 0 0.0 0.00 1.0e+00 PFDN1
Whole body water mass 1.40 3 2 6.1 0.00 1.0e+00 IQCH PRPS1P2 XKR6
Leg predicted mass (right) 1.67 3 2 6.1 0.00 1.0e+00 IQCH PRPS1P2 XKR6
Arm fat mass (left) 3.21 4 3 9.1 -0.81 1.9e-01 ARNTL IQCH TTC12 XKR6
Number of self-reported non-cancer illnesses 2.80 2 1 3.0 0.00 1.0e+00 ARNTL IQCH
Miserableness 5.21 4 1 3.0 0.98 2.2e-02 ARNTL PCCB TTC12 XKR6
Guilty feelings 9.27 4 2 6.1 0.98 2.5e-02 ARNTL TTC12 XKR6 ZDHHC5
Medication: Blood pressure 2.97 1 1 3.0 0.00 1.0e+00 XKR6
Medication: Bendroflumethiazide 3.22 1 1 3.0 0.00 1.0e+00 XKR6
Ever smoked 2.95 2 0 0.0 0.00 1.0e+00 IQCH PRPS1P2
Basal metabolic rate 1.54 3 2 6.1 0.00 1.0e+00 IQCH PRPS1P2 XKR6
Leg fat percentage (left) 3.14 5 1 3.0 -0.34 5.8e-01 ARNTL IQCH MNT TTC12 XKR6
Arm fat-free mass (left) 1.44 3 1 3.0 0.00 1.0e+00 IQCH PRPS1P2 XKR6
Number of operations (self-reported) 2.30 1 0 0.0 0.00 1.0e+00 IQCH
Average weekly beer plus cider intake 2.36 1 0 0.0 0.00 1.0e+00 XKR6
Irritability 6.67 4 1 3.0 0.99 1.2e-02 ANKRD10-IT1 FBXL17 XKR6 ZDHHC5
Risk taking 2.73 2 0 0.0 0.00 1.0e+00 PCCB XKR6
Fractured/broken bones in last 5 years 1.99 1 0 0.0 0.00 1.0e+00 IQCH
Diastolic blood pressure, automated reading 2.65 3 2 6.1 0.00 1.0e+00 ARNTL IQCH XKR6
Unable to work because of sickness or disability 2.38 1 0 0.0 0.00 1.0e+00 ZDHHC5
Commuting to job workplace: Cycle 2.16 1 0 0.0 0.00 1.0e+00 MNT
Vascular/heart problems diagnosed by doctor 3.31 4 1 3.0 0.80 2.0e-01 ARNTL DBNDD1 IQCH XKR6
Pain experienced in last month 1.92 1 0 0.0 0.00 1.0e+00 MYO1H
Basal cell carcinoma (self-reported) 4.60 1 1 3.0 0.00 1.0e+00 DBNDD1
Pack years of smoking 2.18 1 0 0.0 0.00 1.0e+00 MNT
Impedance of whole body 2.54 4 2 6.1 0.49 5.1e-01 DBNDD1 MNT PRPS1P2 XKR6
Leg fat mass (left) 3.12 4 2 6.1 -0.80 2.0e-01 ARNTL IQCH TTC12 XKR6
Arm predicted mass (left) 1.47 2 2 6.1 0.00 1.0e+00 PRPS1P2 XKR6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 3 0.0859 1.67
GTEx Adipose Visceral Omentum 3 0.1473 1.71
GTEx Adrenal Gland 2 0.1373 1.79
GTEx Artery Aorta 4 0.1344 1.76
GTEx Artery Coronary 2 0.1691 1.85
GTEx Artery Tibial 5 0.1329 1.71
GTEx Brain Caudate basal ganglia 1 0.1087 1.77
GTEx Brain Cerebellar Hemisphere 2 0.1343 1.77
GTEx Brain Cerebellum 3 0.1514 1.72
GTEx Brain Cortex 1 0.0966 1.94
GTEx Brain Frontal Cortex BA9 2 0.2165 1.77
GTEx Brain Hippocampus 0 0.0000 1.73
GTEx Brain Hypothalamus 0 0.0000 1.75
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.78
GTEx Brain Putamen basal ganglia 1 0.1603 1.78
GTEx Breast Mammary Tissue 4 0.2026 1.75
GTEx Breast Mammary Tissue (Male) 2 0.1676 1.73
GTEx Breast Mammary Tissue (Female) 2 0.1217 1.69
GTEx Cells EBV-transformed lymphocytes 2 0.1405 1.83
GTEx Cells Transformed fibroblasts 3 0.0714 1.66
GTEx Colon Sigmoid 4 0.2736 1.83
GTEx Colon Transverse 6 0.2907 1.80
GTEx Esophagus Gastroesophageal Junction 2 0.1384 1.89
GTEx Esophagus Mucosa 7 0.2108 1.66
GTEx Esophagus Muscularis 4 0.1238 1.78
GTEx Heart Atrial Appendage 3 0.1900 1.75
GTEx Heart Left Ventricle 5 0.3268 1.77
GTEx Liver 0 0.0000 1.63
GTEx Lung 6 0.2088 1.73
GTEx Muscle Skeletal 4 0.1384 1.73
GTEx Nerve Tibial 5 0.1157 1.70
GTEx Ovary 0 0.0000 1.85
GTEx Pancreas 5 0.3064 1.82
GTEx Pituitary 1 0.0897 1.75
GTEx Prostate 1 0.1198 1.79
GTEx Skin Not Sun Exposed Suprapubic 6 0.2440 1.77
GTEx Skin Sun Exposed Lower leg 6 0.1648 1.70
GTEx Small Intestine Terminal Ileum 2 0.4338 1.91
GTEx Spleen 3 0.2126 1.83
GTEx Stomach 3 0.2063 1.82
GTEx Testis 4 0.1268 1.75
GTEx Thyroid 3 0.0750 1.74
GTEx Uterus 2 0.3527 1.94
GTEx Vagina 2 0.3150 2.00
GTEx Whole Blood 1 0.0502 1.67
METSIM Adipose 1 0.0217 1.56
NTR Blood 2 0.0833 1.56
ROSMAP Brain Pre-frontal Cortex 11 0.2505 1.77
YFS Blood 2 0.0433 1.54
CommonMind Brain Pre-frontal Cortex 3 0.0558 1.63
TCGA Breast Tumor 2 0.2608 1.76
TCGA Breast Normal 1 0.0238 1.50
TCGA Ovarian Tumor 3 0.1027 1.58
TCGA Prostate Tumor 3 0.0867 1.55