TWAS hub - SYT14

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Colon Adenocarcinoma	0.083	0.042	1.7e-03	0.037	0.015	-0.002	NA	0.017	3.3e-03	0.04500	0.4500	NA	0.03500
2	TCGA	Stomach Adenocarcinoma	0.108	0.046	2.2e-05	0.061	0.052	0.035	NA	0.051	3.2e-05	0.00013	0.0013	NA	0.00014

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Worry too long after embarrassment	10.1	17.0	26.6	-5.2	-2.7
Smoking Status	8.6	20.7	24.1	-4.2	-4.9
Length of working week for main job	7.1	7.8	12.7	3.6	1.7
Alcohol intake frequency.	6.9	16.0	18.3	4.3	3.7
Body mass index (BMI)	6.0	25.6	32.8	5.7	4.3
Arm fat mass (left)	5.9	24.3	34.3	5.9	3.8
Arm fat mass (right)	5.8	23.7	32.9	5.7	3.8
Arm fat percentage (left)	5.5	21.9	31.9	5.7	3.5
Basal cell carcinoma (self-reported)	5.4	6.4	8.5	-2.0	-2.9
Arm fat percentage (right)	5.3	20.9	29.8	5.5	3.5
Leg fat mass (left)	5.2	20.4	28.9	5.4	3.5
Worry (Nagel 2018)	4.9	10.3	13.7	-3.7	-2.6
Leg fat mass (right)	4.9	19.1	27.6	5.2	3.3
Ever smoked	4.9	8.6	12.0	-3.5	-2.3
Happiness	4.7	5.7	10.8	-3.3	-0.8
Past tobacco smoking	4.6	8.4	12.7	3.6	2.0
Mouth/teeth dental problems	4.6	7.1	7.7	2.8	2.6
BMI	4.5	26.0	35.5	6.0	4.1
LDL Cholesterol	4.4	6.9	7.3	-2.6	-2.7
Hip circumference	4.4	18.8	25.1	5.0	3.5
Whole body fat mass	4.4	18.4	27.8	5.3	3.0
Body Mass Index (BMI) (2010)	4.3	5.9	10.0	3.2	1.3
Reason for reducing amount of alcohol drunk: Health precaution	4.3	5.0	6.2	-2.5	-2.0
Waist circumference	4.1	14.9	23.6	4.9	2.5
Body fat percentage	4.1	16.2	24.1	4.9	2.9
Leg fat percentage (left)	4.1	15.0	21.2	4.6	2.9
Trunk fat mass	4.0	17.0	26.2	5.1	2.8
Hair/balding pattern: Pattern 4	4.0	9.8	15.8	-4.0	-2.0
Age started oral contraceptive pill	4.0	5.0	7.5	2.7	1.6
Neuroticism (Nagel 2018)	3.9	9.2	15.4	-3.9	-1.7
Weight	3.9	19.2	28.4	5.3	3.1
Seen doctor (GP) for nerves, anxiety, tension or depression	3.9	5.9	11.4	-3.4	-0.7
Leg fat percentage (right)	3.9	14.0	20.4	4.5	2.8
Trunk fat percentage	3.6	14.3	21.9	4.7	2.6
Myopia	3.6	5.2	9.8	0.8	3.1
Neuroticism (2016)	3.5	5.1	5.4	-2.3	-2.2
Lung FVC	3.4	17.4	30.6	-5.5	-2.0
Smoking status: Current	3.3	5.3	8.1	-1.6	-2.9
Reaction Time	3.1	5.9	6.1	-2.4	-2.5
Birth weight of first child	3.1	5.6	7.1	2.0	2.7
Nervous feelings	3.0	5.6	5.9	-2.3	-2.4
Mean time to correctly identify matches	3.0	5.7	6.0	-2.3	-2.5
Alcohol intake versus 10 years previously	2.9	4.4	5.9	2.4	1.7
Average weekly red wine intake	2.9	4.3	4.7	-2.2	-2.0
Neuroticism score	2.8	5.7	8.9	-3.0	-1.6
Forced vital capacity (FVC)	2.7	10.3	16.8	-4.1	-2.0
Neuroticism	2.6	6.2	10.2	-3.2	-1.4
Qualifications: CSEs or equivalent	2.6	3.4	5.2	1.3	2.3
Commuting to job workplace: Car/motor vehicle	2.6	3.0	5.0	1.0	2.2
Diverticular disease/diverticulitis (self-reported)	2.5	2.9	3.7	-1.9	-1.5
Impedance of leg (left)	2.5	11.9	12.5	-3.5	-3.4
Frequency of tenseness / restlessness in last 2 weeks	2.5	3.9	5.5	-2.3	-1.5
Mouth/teeth dental problems: Dentures	2.5	4.3	7.3	-1.1	-2.7
Osteoporosis (self-reported)	2.5	3.1	4.1	2.0	1.4
Type 2 Diabetes (T2D) (2012)	2.4	2.8	4.8	-0.9	-2.2
Worrier / anxious feelings	2.4	4.5	7.6	-2.8	-1.2
Number of live births	2.4	3.4	4.0	2.0	1.7
Number of full sisters	2.4	2.9	4.4	2.1	1.2
Diabetes diagnosed by doctor	2.4	4.0	8.0	2.8	-0.0
Miserableness	2.4	4.1	7.2	-2.7	-1.0
Impedance of leg (right)	2.3	11.1	11.2	-3.3	-3.4
Current tobacco smoking	2.3	3.7	6.4	-1.0	-2.5
Age at First Birth	2.2	3.2	6.2	-0.6	2.5
Sensitivity / hurt feelings	2.2	3.7	7.1	-2.7	-0.6
Medication: Atenolol	2.2	2.7	4.7	-0.9	-2.2
Forced expiratory volume in 1-second (FEV1)	2.2	7.3	11.4	-3.4	-1.8
Mother’s age at death	2.2	2.7	4.9	2.2	0.7
Leg predicted mass (left)	2.1	10.9	15.5	3.9	2.5
Suffer from ‘nerves’	2.1	3.4	3.6	-1.9	-1.8
Medication: Aspirin	2.1	2.8	5.5	-0.4	-2.3
Supplements: Vitamin C	2.1	2.4	3.0	1.4	1.7
Leg fat-free mass (left)	2.0	10.7	15.6	4.0	2.4
Financial difficulties in last 2 years	2.0	2.7	3.9	1.2	2.0
Medication: Cholesterol lowering	2.0	3.1	5.2	-1.1	-2.3
Forced vital capacity (FVC), Best measure	2.0	7.5	11.2	-3.4	-1.9
Basal metabolic rate	2.0	11.1	15.2	3.9	2.6
Impedance of whole body	2.0	10.0	12.2	-2.8	-3.5
Depression (self-reported)	1.9	2.3	4.4	-2.1	-0.4
Pulse wave peak to peak time	1.9	2.2	3.4	-1.8	-1.0
Medication: Ibuprofen	1.9	2.3	2.7	1.6	1.4
Leg fat-free mass (right)	1.9	10.4	14.4	3.8	2.5
Leg predicted mass (right)	1.9	10.2	14.1	3.8	2.5
Financial situation satisfaction	1.9	2.4	4.8	0.3	2.2
High cholesterol (Self-reported)	1.9	3.4	5.3	-1.2	-2.3
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.2	3.3	1.8	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	2.6	1.6	1.2
Back pain experienced in last month	1.8	2.6	3.6	1.2	1.9
Commuting to job workplace: Public transport	1.8	2.2	2.4	-1.6	-1.4
Bipolar Disorder (2011)	1.7	1.6	3.0	-1.7	-0.6
Average weekly spirits intake	1.7	2.1	2.5	1.6	1.3
Pulse wave Arterial Stiffness index	1.7	2.0	3.5	1.9	0.8
Irritability	1.7	2.9	5.1	-2.3	-0.8
Arm predicted mass (left)	1.7	8.6	11.3	3.4	2.4
Depression (Nagel 2018)	1.6	2.5	4.9	-2.2	0.0
HDL Cholesterol	1.6	2.6	5.1	0.4	2.3
Diabetes (self-reported)	1.6	2.5	4.7	2.2	-0.6
Medication: Lansoprazole	1.6	1.8	2.9	-0.8	-1.7
Arm fat-free mass (right)	1.6	8.3	11.1	3.3	2.4
Arm predicted mass (right)	1.6	8.3	11.4	3.4	2.3
Illnesses of siblings: Diabetes	1.6	2.0	2.4	1.3	1.6
Smoking status: Previous	1.6	2.4	4.1	-2.0	-0.8
Osteoarthritis (self-reported)	1.6	2.1	2.2	1.4	1.5
Arm fat-free mass (left)	1.6	8.2	10.6	3.2	2.4
Pain experienced in last month	1.6	2.7	3.2	-1.4	-1.8
Heel T-Score	1.5	11.9	22.9	-4.8	-0.9
Chronotype (morning person)	1.5	3.5	4.7	2.2	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.8	6.4	-2.5	-1.8
Exposure to tobacco smoke at home	1.5	1.6	2.2	-1.1	-1.5
Tense / ‘highly strung’	1.5	2.5	3.4	-1.8	-1.3
Crohns Disease (2012)	1.4	2.2	3.9	0.7	-2.0
Medication: Simvastatin	1.4	2.0	2.7	-1.1	-1.6
Impedance of arm (right)	1.4	6.4	8.1	-2.1	-2.9
Mouth/teeth dental problems: Bleeding gums	1.4	1.9	3.3	-1.8	-0.7
Comparative body size at age 10	1.4	3.9	5.7	1.5	2.4
Whole body fat-free mass	1.4	7.8	10.6	3.3	2.2
Friendships satisfaction	1.4	1.8	3.5	-1.9	-0.2
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	3.9	-2.0	-0.8
Whole body water mass	1.4	7.8	10.6	3.3	2.2
Alzheimer’s Disease (in father)	1.3	1.4	2.7	-0.3	1.6
Rheumatoid Arthritis	1.3	1.7	2.1	1.4	1.2
Ever had hysterectomy (womb removed)	1.3	1.5	2.1	1.4	0.9
Pack years adult smoking proportion	1.3	1.9	3.8	1.9	0.3
Heart attack	1.3	1.7	2.1	1.1	1.4
Pain all over the body in last month	1.3	1.4	1.8	1.4	1.0
Noisy workplace	1.3	1.6	2.4	1.5	0.9
Impedance of arm (left)	1.3	5.9	8.8	-1.7	-3.0
Leg pain on walking	1.3	1.7	2.5	-1.6	-0.9
Ever taken oral contraceptive pill	1.3	1.4	2.5	-1.6	0.6
Heart attack/myocardial infarction (self-reported)	1.3	1.7	1.9	1.2	1.4
Pack years of smoking	1.3	1.9	3.6	1.9	0.4
Lupus	1.2	1.9	2.2	1.5	1.3
Breastfed as a baby	1.2	1.5	2.0	1.0	1.4
Medication: Aspirin	1.2	1.5	3.0	0.0	-1.7
Medication: Gliclazide	1.2	1.4	1.8	1.3	-1.0
Pain type(s) experienced in last month: Hip pain	1.2	1.6	2.6	1.6	0.7
Cardiovascular Disease	1.1	3.8	6.5	1.0	-2.5
Type 2 Diabetes (T2D) (2018)	1.1	2.0	3.6	1.9	-0.6
Medication: Co-codamol	1.1	1.2	1.6	0.9	1.3
Hair/balding pattern: Pattern 3	1.1	1.6	1.6	1.3	1.3
Ever depressed for a whole week	1.1	1.4	2.7	-1.6	0.3
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.1	1.4	0.8
Bipolar Disorder or Schizophrenia	1.0	2.4	4.3	-2.1	-0.7
Depressed Affect (Nagel 2018)	1.0	2.0	3.1	-1.8	-1.0
Schizophrenia vs Biploar Disorder	1.0	1.3	2.5	1.6	-0.1
Ovarian Cancer	1.0	1.3	1.9	-1.4	-0.8
Hypothyroidism (self reported)	1.0	2.4	3.5	-1.9	-1.1
Hand grip strength (right)	1.0	2.6	3.6	-1.3	-1.9
Relative age voice broke	1.0	1.5	2.0	-1.0	-1.4
Trunk predicted mass	1.0	5.8	7.5	2.7	2.0
High blood pressure (siblings)	1.0	1.4	2.0	-0.9	-1.4
Number of full brothers	1.0	1.2	1.8	0.8	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.5	-1.6	-0.2
Medication for pain relief, constipation, heartburn	1.0	1.6	3.1	-1.8	0.5
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.1	2.2	0.4	1.5
Blood Red Count	0.9	9.1	15.7	4.0	1.6
Waist Hip Ratio (WHR)	0.9	4.2	7.9	-0.8	-2.8
Number of treatments/medications taken	0.9	1.5	2.8	0.5	-1.7
Medication: Metformin	0.9	1.3	1.7	1.3	-0.9
High blood pressure	0.9	2.6	3.3	1.3	-1.8
Chronic bronchitis/emphysema (father)	0.9	1.1	1.6	0.7	1.3
Trunk fat-free mass	0.9	5.2	6.8	2.6	1.9
Overall health rating	0.9	1.9	3.1	-0.8	-1.8
Hypertension (Self-reported)	0.9	2.5	3.2	1.8	-1.4
Medication: Blood pressure	0.9	1.7	3.2	0.5	-1.8
Illnesses of father: High blood pressure	0.9	1.1	1.6	-0.8	-1.3
Diastolic blood pressure, automated reading	0.9	2.9	5.3	2.3	0.7
Schizophrenia (2018)	0.8	1.6	2.2	-1.5	-1.1
Prostate Cancer	0.8	1.2	2.1	1.5	0.4
Hand grip strength (left)	0.8	2.0	2.9	-1.1	-1.7
Severe depression (siblings)	0.8	0.8	1.3	-1.2	-0.6
Health satisfaction	0.8	1.1	2.1	-1.5	-0.1
Medication: Seretide 50 evohaler	0.8	0.9	1.5	1.2	0.6
Mineral and other dietary supplements	0.8	1.1	2.1	0.4	-1.4
Guilty feelings	0.8	1.1	2.0	-1.4	0.5
Bipolar Disorder (2018)	0.7	1.1	2.2	-1.5	0.1
Crohns Disease (2017)	0.7	1.6	2.1	1.0	-1.4
Primary Biliary Cirrhosis	0.7	1.0	1.1	-1.1	-0.9
High blood pressure (mother)	0.7	1.0	1.6	-1.3	-0.6
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.4	-1.2	-0.5
Pulse rate	0.7	1.2	2.3	1.5	0.0
Medication: Paracetamol	0.7	1.2	1.9	1.4	-0.7
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.6	-1.6	-0.5
Medication: Blood pressure	0.7	1.2	2.1	1.5	-0.6
Heart disease (mother)	0.7	0.9	1.8	1.3	0.2
Family relationship satisfaction	0.7	0.8	1.1	-1.1	-0.7
Medication: Bendroflumethiazide	0.7	1.0	2.0	-0.0	-1.4
Vascular/heart problems diagnosed by doctor	0.7	1.9	2.4	-1.2	1.6
Systolic Blood Pressure	0.6	2.9	5.6	-0.3	-2.4
Frequency of depressed mood in last 2 weeks	0.6	0.8	0.9	-0.9	0.9
Angina	0.6	0.8	1.6	1.3	0.2
Falls in the last year	0.6	0.9	1.4	0.6	1.2
Lung cancer (father)	0.6	0.7	1.3	1.1	-0.1
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.1	-1.0	-1.0
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.3	-0.8	1.1
Wheeze or whistling in the chest in last year	0.6	1.2	2.1	0.4	-1.5
Age at last live birth	0.6	0.9	1.1	-0.8	1.1
Breast cancer (self-reported)	0.6	0.8	1.2	-0.6	-1.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.1	-0.6	1.1
Medication: Lisinopril	0.6	0.7	1.4	1.2	0.3
Irritable Bowel Disease (IBD)	0.5	1.2	2.3	0.3	-1.5
Schizophrenia (2014)	0.5	1.0	1.1	-1.0	-1.0
Ulcerative Colitis	0.5	0.7	0.8	-0.9	-0.7
Height	0.5	10.3	18.5	-1.5	-4.3
Systolic blood pressure, automated reading	0.5	1.5	2.7	1.6	-0.5
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	0.9	1.0	0.5
Vitamin and mineral supplements	0.5	0.7	1.4	-0.2	-1.2
Diabetes (mother)	0.5	0.7	1.4	0.0	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	1.5	-1.2	0.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.5	-0.7	-0.7
Supplements: Glucosamine	0.5	0.6	0.8	-0.7	0.9
Alcohol usually taken with meals	0.5	0.8	1.6	1.3	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	1.6	-1.3	0.9
Qualifications: None of the above	0.5	1.0	2.0	1.4	0.1
Medication: Ramipril	0.5	0.6	0.8	0.9	-0.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.6	-0.8	0.7
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.3	1.2	-0.1
Shortness of breath walking on level ground	0.5	0.6	0.7	0.8	-0.7
Angina (self-reported)	0.5	0.6	1.2	1.1	0.1
Knee pain experienced in last month	0.5	0.8	1.1	-1.0	0.7
Mood swings	0.5	0.9	1.8	-1.3	-0.2
Medication: Paracetamol	0.5	0.7	1.0	1.0	-0.7
Cholesterol lowering medication	0.5	0.7	1.1	-0.6	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	0.7	0.7	0.9
Heart disease (siblings)	0.5	0.6	0.9	0.9	-0.5
Intelligence (Savage-Jansen 2018)	0.4	1.4	2.6	-1.6	-0.3
Alzheimer’s Disease (including proxy)	0.4	0.6	1.1	-0.3	1.1
Verbal and Numeric Reasoning (VNR)	0.4	0.8	1.7	-1.3	0.2
Breast Cancer	0.4	1.0	2.0	-0.1	1.4
Blood White Count	0.4	3.2	6.4	0.3	-2.5
Tanning	0.4	5.2	9.3	-3.0	-1.0
Supplements: Zinc	0.4	0.5	1.0	0.1	1.0
Medication: Levothyroxine sodium	0.4	0.6	1.1	-1.1	-0.3
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	-0.9	-0.3
Had menopause	0.4	0.5	0.9	0.9	0.4
Prospective memory result	0.4	0.5	0.5	0.6	0.7
Medication: Amlodipine	0.4	0.6	0.7	0.9	-0.7
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.8	0.9	0.3
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.5	0.6	0.7
Neck or shoulder pain in last month	0.4	0.6	1.0	0.4	1.0
Medication: Omeprazole	0.4	0.4	0.7	0.9	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.5	0.2	-1.2
Long-standing illness, disability or infirmity	0.4	0.6	1.3	1.1	-0.1
Number of self-reported non-cancer illnesses	0.4	0.7	1.3	1.1	0.3
Eye problems/disorders: Glaucoma	0.4	0.5	0.7	0.9	0.5
Fractured/broken bones in last 5 years	0.4	0.5	0.7	-0.5	-0.8
Ulcerative Colitis (UC)	0.3	0.6	0.8	-0.7	-0.9
Major Depression (MDD)	0.3	0.4	0.4	-0.6	-0.7
Coronary Artery Disease (CAD)	0.3	0.4	0.7	-0.3	-0.8
Mean Putamen Volume	0.3	0.3	0.3	-0.5	-0.6
Triglycerides	0.3	0.4	0.6	0.5	-0.8
Allergy or Eczema	0.3	0.8	1.6	-1.2	-0.2
Hearing difficulty/problems: Yes	0.3	0.4	0.7	-0.3	0.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.6	0.2	0.8
Maternal smoking around birth	0.3	0.4	0.7	0.8	-0.3
Taking other prescription medications	0.3	0.5	0.9	0.2	-0.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.5	-0.5	-0.7
Hayfever, allergic rhinitis or eczema	0.3	0.7	0.7	-0.8	-0.8
Had other major operations	0.3	0.3	0.4	0.6	0.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	0.2	0.9
Time employed in main current job	0.3	0.4	0.7	-0.1	-0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.6	0.7	-0.7	-0.9
Birth weight	0.3	0.7	0.9	1.0	0.7
Emphysema/chronic bronchitis	0.3	0.4	0.6	0.8	0.3
Medication: Allopurinol	0.3	0.4	0.6	0.4	0.8
Pulse rate, automated reading	0.3	0.9	1.6	0.3	-1.3
Comparative height size at age 10	0.3	1.7	3.2	-0.3	-1.8
Chest pain or discomfort	0.3	0.4	0.9	0.1	-0.9
Illnesses of father: Heart disease	0.3	0.4	0.7	0.8	0.3
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.6	-0.8	-0.2
Eye problems/disorders: Cataract	0.3	0.3	0.4	-0.5	-0.6
Medication for cholesterol	0.3	0.4	0.7	-0.8	0.3
Risk taking	0.3	0.4	0.7	0.4	0.8
HbA1C	0.2	0.2	0.3	0.4	0.5
Respiratory disease	0.2	0.5	1.0	-0.1	-1.0
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.3	0.6	0.4
Townsend deprivation index at recruitment	0.2	0.4	0.7	0.1	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	-0.4	0.7
Age when periods started (menarche)	0.2	0.4	0.7	0.8	0.2
Serious illness, injury or assault to yourself	0.2	0.2	0.4	0.6	-0.2
Multivitamins +/- minerals	0.2	0.3	0.4	-0.7	0.3
Sitting height	0.2	1.3	2.4	-0.5	-1.6
Fluid intelligence score	0.2	0.5	0.9	-1.0	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.5	-0.4	-0.7
Asthma	0.2	0.5	0.9	1.0	0.0
Standing height	0.2	2.1	4.2	-0.1	-2.0
Peak expiratory flow (PEF)	0.2	0.5	1.0	0.2	1.0
Blood clot in the leg (DVT)	0.2	0.3	0.3	0.4	0.6
Headache pain in last month	0.2	0.3	0.4	-0.3	-0.7
Glaucoma (self-reported)	0.2	0.3	0.5	0.2	0.7
Age at first live birth	0.2	0.3	0.3	-0.5	0.6
Had major operations	0.2	0.2	0.4	-0.6	-0.1
Loneliness, isolation	0.2	0.2	0.3	0.6	0.3
Ever had bowel cancer screening	0.2	0.2	0.4	0.2	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.7	-0.2	0.8
Average weekly champagne plus white wine intake	0.2	0.3	0.6	0.2	0.8
Wears glasses or contact lenses	0.2	0.2	0.3	-0.5	0.4
Hearing aid user	0.2	0.2	0.2	0.4	0.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	-0.1	0.7
Alcohol drinker status: Never	0.2	0.3	0.5	0.7	-0.1
Average weekly beer plus cider intake	0.2	0.4	0.4	0.6	0.6
Unable to work because of sickness or disability	0.2	0.2	0.5	-0.1	-0.7
Commuting to job workplace: Cycle	0.2	0.3	0.5	0.2	-0.7
Supplements: Calcium	0.2	0.2	0.3	-0.0	0.6
Alcohol drinker status: Previous	0.2	0.2	0.4	-0.2	0.6
Alzheimer’s Disease (in mother)	0.1	0.1	0.1	-0.2	0.3
Fasting Glucose	0.1	0.1	0.2	0.3	-0.4
Blood Eosinophil Count	0.1	0.8	1.4	-0.5	-1.2
Blood Platelet Count	0.1	1.3	1.8	1.3	-0.8
Diabetes (father)	0.1	0.1	0.2	0.4	0.2
Number of incorrect matches in round	0.1	0.1	0.1	0.3	-0.2
Hearing difficulty/problems with background noise	0.1	0.2	0.3	-0.6	0.1
Allergy	0.1	0.1	0.2	0.2	0.4
Illnesses of siblings	0.1	0.2	0.3	-0.3	0.5
Father’s age at death	0.1	0.1	0.2	-0.0	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.3	0.1	-0.5
Illnesses of mother	0.1	0.1	0.2	0.4	0.3
Exposure to tobacco smoke outside home	0.1	0.2	0.3	-0.5	-0.2
Number of children fathered	0.1	0.1	0.2	0.5	0.1
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.3	0.5
Migraine (self-reported)	0.1	0.1	0.2	-0.0	-0.4
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	-0.5	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.4	-0.1
Qualifications: nursing, teaching	0.1	0.1	0.2	0.4	-0.1
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.4	0.0
Medication: Atorvastatin	0.1	0.2	0.3	0.5	-0.2
Number of operations (self-reported)	0.1	0.1	0.1	-0.3	0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	-0.3	-0.1
Lung FEV1/FVC ratio	0.0	0.2	0.5	0.2	-0.7
Hair Pigment	0.0	1.3	2.2	-1.5	-0.5
Relative age of first facial hair	0.0	0.1	0.1	-0.3	-0.3
Medication for hormone replacement therapy	0.0	0.1	0.1	-0.3	0.1
Average weekly fortified wine intake	0.0	0.1	0.1	-0.1	-0.3
Fed-up feelings	0.0	0.0	0.0	0.0	0.0
Stomach or abdominal pain in last month	0.0	0.1	0.1	0.0	0.3
Pulse wave reflection index	0.0	0.1	0.1	0.3	0.1
Loud music exposure frequency	0.0	0.0	0.1	-0.2	0.0
Gout (self-reported)	0.0	0.0	0.0	0.2	-0.2
Qualifications: College or University degree	0.0	0.1	0.1	0.3	0.4
Commuting to job workplace: Walk	0.0	0.0	0.1	-0.2	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	-0.0	-0.0
Asthma (self-reported)	0.0	0.1	0.2	0.4	-0.1

Hub : Genes

SYT14

Models

Trait associations