Hub : Traits :

Medication: Aspirin

17 significantly associated models · 8 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 109098737 110517617 2 1 2.0e-10 2.3e-10 1.0e+00 100 PSRC1
2 4 52683607 53598975 2 1 1.0e-07 2.2e-07 6.0e-02 87 SGCB
3 6 160071844 161571560 1 1 4.0e-08 3.5e-07 3.9e-06 18 SLC22A3
4 9 21303958 22819407 2 1 2.5e-10 6.1e-17 4.4e-08 57 CDKN2B
5 15 90730363 92135418 1 1 1.6e-08 1.4e-07 8.0e-01 100 FES

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.60 1 0 0.0 0.00 1.0e+00 FES
Irritable Bowel Disease (IBD) 1.25 1 0 0.0 0.00 1.0e+00 FES
Major Depression (MDD) 3.47 1 0 0.0 0.00 1.0e+00 FES
Breast Cancer 3.89 2 0 0.0 0.00 1.0e+00 CDKN2B FES
Ovarian Cancer 1.96 1 0 0.0 0.00 1.0e+00 FES
Body Mass Index (BMI) (2010) 3.00 1 0 0.0 0.00 1.0e+00 SGCB
Coronary Artery Disease (CAD) 24.38 3 2 6.1 0.00 1.0e+00 CDKN2B PSRC1 SLC22A3
Crohns Disease (2012) 1.72 1 0 0.0 0.00 1.0e+00 FES
HDL Cholesterol 2.94 1 0 0.0 0.00 1.0e+00 PSRC1
LDL Cholesterol 99.78 1 1 3.0 0.00 1.0e+00 PSRC1
Schizophrenia 3.65 1 1 3.0 0.00 1.0e+00 FES
Type 2 Diabetes (T2D) 3.92 1 0 0.0 0.00 1.0e+00 CDKN2B
Blood Platelet Count 1.17 3 0 0.0 0.00 1.0e+00 CDKN2B SGCB SLC22A3
Blood Red Count 0.56 2 0 0.0 0.00 1.0e+00 CDKN2B FES
Blood White Count 2.02 4 1 3.0 -0.61 3.9e-01 CDKN2B FES PSRC1 SGCB
Heel T-Score 0.60 1 0 0.0 0.00 1.0e+00 PSRC1
BMI 1.76 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Height 1.54 4 3 9.1 0.61 3.9e-01 FES PSRC1 SGCB SLC22A3
Waist Hip Ratio (WHR) 3.28 1 1 3.0 0.00 1.0e+00 SLC22A3
Systolic Blood Pressure 12.90 3 1 3.0 0.00 1.0e+00 FES SGCB SLC22A3
Smoking Status 3.37 2 0 0.0 0.00 1.0e+00 FES PSRC1
Allergy or Eczema 1.97 2 0 0.0 0.00 1.0e+00 FES SLC22A3
Cardiovascular Disease 16.30 4 2 6.1 -0.99 9.8e-03 FES PSRC1 SGCB SLC22A3
Respiratory disease 2.31 1 0 0.0 0.00 1.0e+00 FES
Type 2 Diabetes (T2D) 4.47 3 0 0.0 0.00 1.0e+00 CDKN2B SGCB SLC22A3
Lung FEV1/FVC ratio 1.27 1 1 3.0 0.00 1.0e+00 PSRC1
Chronotype (morning person) 1.70 1 0 0.0 0.00 1.0e+00 SGCB
Hair Pigment 0.76 2 2 6.1 0.00 1.0e+00 CDKN2B FES
Number of treatments/medications taken 7.01 3 1 3.0 0.00 1.0e+00 FES PSRC1 SGCB
Sensitivity / hurt feelings 1.89 1 0 0.0 0.00 1.0e+00 FES
Hearing difficulty/problems: Yes 3.02 2 0 0.0 0.00 1.0e+00 PSRC1 SGCB
Other serious medical condition/disability diagnosed by doctor 1.43 1 0 0.0 0.00 1.0e+00 PSRC1
Systolic blood pressure, automated reading 9.96 2 1 3.0 0.00 1.0e+00 FES SGCB
Angina 32.21 4 4 12.1 0.99 1.4e-02 CDKN2B FES PSRC1 SLC22A3
Medication: Metformin 5.64 2 0 0.0 0.00 1.0e+00 CDKN2B SGCB
Impedance of leg (right) 1.57 1 0 0.0 0.00 1.0e+00 FES
Leg fat-free mass (left) 2.19 4 0 0.0 -0.53 4.7e-01 FES PSRC1 SGCB SLC22A3
Trunk fat percentage 2.34 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Current tobacco smoking 2.23 1 0 0.0 0.00 1.0e+00 FES
High blood pressure 10.18 2 1 3.0 0.00 1.0e+00 FES SLC22A3
Medication: Atenolol 12.12 3 1 3.0 0.00 1.0e+00 CDKN2B FES PSRC1
Sitting height 1.05 2 0 0.0 0.00 1.0e+00 FES SLC22A3
High blood pressure (mother) 12.60 1 1 3.0 0.00 1.0e+00 FES
Body mass index (BMI) 1.18 1 0 0.0 0.00 1.0e+00 SGCB
Impedance of leg (left) 1.40 1 0 0.0 0.00 1.0e+00 FES
Leg predicted mass (left) 2.24 4 0 0.0 -0.53 4.7e-01 FES PSRC1 SGCB SLC22A3
Trunk fat mass 2.65 2 1 3.0 0.00 1.0e+00 SGCB SLC22A3
Waist circumference 1.52 1 0 0.0 0.00 1.0e+00 SGCB
Number of incorrect matches in round 2.09 1 0 0.0 0.00 1.0e+00 FES
Alcohol usually taken with meals 2.26 1 0 0.0 0.00 1.0e+00 FES
Mouth/teeth dental problems 1.63 1 0 0.0 0.00 1.0e+00 CDKN2B
Heart attack 24.37 4 3 9.1 1.00 3.2e-03 CDKN2B FES PSRC1 SLC22A3
Allergy 1.59 1 0 0.0 0.00 1.0e+00 FES
Diabetes (self-reported) 3.83 1 0 0.0 0.00 1.0e+00 SGCB
Medication: Ramipril 6.79 2 0 0.0 0.00 1.0e+00 FES SLC22A3
Medication: Simvastatin 31.00 5 1 3.0 0.95 1.4e-02 CDKN2B FES PSRC1 SGCB SLC22A3
Illnesses of siblings 7.11 2 1 3.0 0.00 1.0e+00 FES SGCB
Weight 2.38 2 1 3.0 0.00 1.0e+00 SGCB SLC22A3
Impedance of arm (right) 1.04 2 0 0.0 0.00 1.0e+00 CDKN2B PSRC1
Arm fat percentage (right) 1.93 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Trunk fat-free mass 2.30 3 1 3.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3
Hip circumference 2.28 2 1 3.0 0.00 1.0e+00 SGCB SLC22A3
Alcohol intake versus 10 years previously 2.32 1 0 0.0 0.00 1.0e+00 SGCB
Father's age at death 10.74 4 0 0.0 -1.00 8.8e-04 CDKN2B FES PSRC1 SGCB
Medication: Ibuprofen (e.g. Nurofen) 2.12 1 0 0.0 0.00 1.0e+00 SLC22A3
Medication: Cholesterol lowering 42.40 5 2 6.1 0.93 2.3e-02 CDKN2B FES PSRC1 SGCB SLC22A3
Prospective memory result 2.88 1 0 0.0 0.00 1.0e+00 SGCB
Lung cancer (father) 4.20 1 0 0.0 0.00 1.0e+00 FES
Illnesses of mother 10.18 2 1 3.0 0.00 1.0e+00 CDKN2B FES
Pulse wave Arterial Stiffness index 3.29 1 0 0.0 0.00 1.0e+00 CDKN2B
Impedance of arm (left) 0.85 1 0 0.0 0.00 1.0e+00 PSRC1
Arm fat mass (right) 2.33 2 1 3.0 0.00 1.0e+00 SGCB SLC22A3
Trunk predicted mass 2.29 3 1 3.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3
Standing height 1.38 3 1 3.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3
Breastfed as a baby 2.97 1 0 0.0 0.00 1.0e+00 FES
Hair/balding pattern: Pattern 4 1.59 1 0 0.0 0.00 1.0e+00 FES
Birth weight of first child 5.65 1 1 3.0 0.00 1.0e+00 FES
Pulse wave reflection index 2.55 1 0 0.0 0.00 1.0e+00 SLC22A3
Headache pain in last month 2.50 1 0 0.0 0.00 1.0e+00 FES
Medication for cholesterol, blood pressure or diabetes 20.42 2 2 6.1 0.00 1.0e+00 FES PSRC1
Glaucoma (self-reported) 8.58 1 1 3.0 0.00 1.0e+00 CDKN2B
Medication: Amlodipine 5.45 1 1 3.0 0.00 1.0e+00 FES
Birth weight 3.63 1 1 3.0 0.00 1.0e+00 FES
High blood pressure (siblings) 7.65 2 1 3.0 0.00 1.0e+00 FES SGCB
Body fat percentage 2.07 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Leg fat percentage (right) 1.33 1 0 0.0 0.00 1.0e+00 SGCB
Arm fat-free mass (right) 2.13 3 0 0.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3
Pulse wave peak to peak time 3.49 1 0 0.0 0.00 1.0e+00 CDKN2B
Medication for pain relief, constipation, heartburn 3.12 1 0 0.0 0.00 1.0e+00 PSRC1
Medication: Blood pressure 10.31 1 1 3.0 0.00 1.0e+00 FES
Angina (self-reported) 33.69 4 4 12.1 0.99 1.0e-02 CDKN2B FES PSRC1 SLC22A3
Medication: Ibuprofen 2.73 1 0 0.0 0.00 1.0e+00 SLC22A3
Mean time to correctly identify matches 1.62 1 0 0.0 0.00 1.0e+00 FES
Heart disease (mother) 15.18 3 2 6.1 0.00 1.0e+00 CDKN2B FES SLC22A3
Whole body fat mass 2.55 2 1 3.0 0.00 1.0e+00 SGCB SLC22A3
Leg fat mass (right) 2.01 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Arm predicted mass (right) 2.29 3 0 0.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3
Comparative height size at age 10 1.74 4 0 0.0 -0.62 3.8e-01 FES PSRC1 SGCB SLC22A3
Chest pain or discomfort 4.08 1 0 0.0 0.00 1.0e+00 CDKN2B
Medication: Aspirin 25.89 5 5 15.2 1.00 1.2e-06 CDKN2B FES PSRC1 SGCB SLC22A3
Hypertension (Self-reported) 10.63 2 1 3.0 0.00 1.0e+00 FES SLC22A3
Illnesses of father: Heart disease 34.18 4 4 12.1 1.00 2.2e-03 CDKN2B FES PSRC1 SLC22A3
Whole body fat-free mass 2.24 3 0 0.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3
Leg fat-free mass (right) 2.24 4 0 0.0 -0.58 4.2e-01 FES PSRC1 SGCB SLC22A3
Arm fat percentage (left) 1.75 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Average weekly red wine intake 2.95 1 0 0.0 0.00 1.0e+00 SLC22A3
Long-standing illness, disability or infirmity 3.30 1 0 0.0 0.00 1.0e+00 CDKN2B
Diabetes diagnosed by doctor 4.33 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Medication for cholesterol 10.94 4 2 6.1 -0.96 3.7e-02 CDKN2B FES PSRC1 SLC22A3
Mineral and other dietary supplements 2.74 1 0 0.0 0.00 1.0e+00 SLC22A3
Breast cancer (self-reported) 2.59 1 0 0.0 0.00 1.0e+00 CDKN2B
Osteoporosis (self-reported) 2.71 1 0 0.0 0.00 1.0e+00 SLC22A3
Medication: Gliclazide 2.77 1 0 0.0 0.00 1.0e+00 CDKN2B
Illnesses of father: None of the above (group 1) 15.61 3 2 6.1 0.00 1.0e+00 CDKN2B FES SLC22A3
Smoking status: Current 2.24 1 0 0.0 0.00 1.0e+00 FES
Whole body water mass 2.18 3 0 0.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3
Leg predicted mass (right) 2.25 4 0 0.0 -0.58 4.2e-01 FES PSRC1 SGCB SLC22A3
Arm fat mass (left) 2.27 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Number of self-reported non-cancer illnesses 4.48 2 0 0.0 0.00 1.0e+00 FES SLC22A3
Eye problems/disorders: Glaucoma 11.87 1 1 3.0 0.00 1.0e+00 CDKN2B
Medication: Blood pressure 8.60 3 1 3.0 0.00 1.0e+00 FES SGCB SLC22A3
Supplements: Fish oil (including cod liver oil) 3.00 1 0 0.0 0.00 1.0e+00 SLC22A3
High cholesterol (Self-reported) 48.38 4 2 6.1 0.84 1.6e-01 FES PSRC1 SGCB SLC22A3
Medication: Bendroflumethiazide 3.65 1 0 0.0 0.00 1.0e+00 FES
Medication: Lisinopril 2.61 1 0 0.0 0.00 1.0e+00 FES
Medication: Atorvastatin 28.76 3 2 6.1 0.00 1.0e+00 CDKN2B PSRC1 SLC22A3
Illnesses of father: High blood pressure 8.85 1 1 3.0 0.00 1.0e+00 FES
Ever smoked 1.40 1 0 0.0 0.00 1.0e+00 FES
Basal metabolic rate 2.28 3 0 0.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3
Leg fat percentage (left) 1.14 1 0 0.0 0.00 1.0e+00 SGCB
Arm fat-free mass (left) 2.05 3 0 0.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3
Risk taking 2.25 1 0 0.0 0.00 1.0e+00 FES
Diastolic blood pressure, automated reading 9.27 2 1 3.0 0.00 1.0e+00 CDKN2B FES
Vascular/heart problems diagnosed by doctor 13.24 3 1 3.0 0.00 1.0e+00 CDKN2B FES SLC22A3
Cholesterol lowering medication 26.90 4 2 6.1 0.98 2.5e-02 CDKN2B PSRC1 SGCB SLC22A3
Basal cell carcinoma (self-reported) 3.95 1 0 0.0 0.00 1.0e+00 CDKN2B
Heart attack/myocardial infarction (self-reported) 24.85 4 3 9.1 1.00 3.4e-03 CDKN2B FES PSRC1 SLC22A3
Heart disease (siblings) 11.91 4 0 0.0 0.97 2.9e-02 CDKN2B FES PSRC1 SLC22A3
Impedance of whole body 1.07 1 0 0.0 0.00 1.0e+00 PSRC1
Leg fat mass (left) 1.95 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Arm predicted mass (left) 2.22 3 0 0.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.32
GTEx Adipose Visceral Omentum 1 0.0491 1.33
GTEx Adrenal Gland 0 0.0000 1.45
GTEx Artery Aorta 0 0.0000 1.35
GTEx Artery Coronary 0 0.0000 1.30
GTEx Artery Tibial 1 0.0266 1.35
GTEx Brain Caudate basal ganglia 0 0.0000 1.32
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.29
GTEx Brain Cerebellum 0 0.0000 1.30
GTEx Brain Cortex 0 0.0000 1.38
GTEx Brain Frontal Cortex BA9 0 0.0000 1.29
GTEx Brain Hippocampus 0 0.0000 1.24
GTEx Brain Hypothalamus 0 0.0000 1.29
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.27
GTEx Brain Putamen basal ganglia 0 0.0000 1.25
GTEx Breast Mammary Tissue 1 0.0507 1.33
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.29
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.31
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.33
GTEx Cells Transformed fibroblasts 1 0.0238 1.30
GTEx Colon Sigmoid 0 0.0000 1.33
GTEx Colon Transverse 0 0.0000 1.33
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.34
GTEx Esophagus Mucosa 1 0.0301 1.33
GTEx Esophagus Muscularis 0 0.0000 1.30
GTEx Heart Atrial Appendage 0 0.0000 1.35
GTEx Heart Left Ventricle 0 0.0000 1.32
GTEx Liver 1 0.1395 1.32
GTEx Lung 1 0.0348 1.34
GTEx Muscle Skeletal 1 0.0346 1.33
GTEx Nerve Tibial 0 0.0000 1.28
GTEx Ovary 0 0.0000 1.41
GTEx Pancreas 0 0.0000 1.36
GTEx Pituitary 0 0.0000 1.34
GTEx Prostate 0 0.0000 1.31
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.34
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.30
GTEx Small Intestine Terminal Ileum 0 0.0000 1.46
GTEx Spleen 0 0.0000 1.47
GTEx Stomach 0 0.0000 1.42
GTEx Testis 0 0.0000 1.28
GTEx Thyroid 0 0.0000 1.35
GTEx Uterus 0 0.0000 1.26
GTEx Vagina 0 0.0000 1.37
GTEx Whole Blood 1 0.0502 1.37
METSIM Adipose 0 0.0000 1.26
NTR Blood 0 0.0000 1.33
ROSMAP Brain Pre-frontal Cortex 1 0.0228 1.32
YFS Blood 0 0.0000 1.26
CommonMind Brain Pre-frontal Cortex 4 0.0744 1.30
TCGA Breast Tumor 0 0.0000 1.29
TCGA Breast Normal 1 0.0238 1.25
TCGA Ovarian Tumor 1 0.0342 1.26
TCGA Prostate Tumor 1 0.0289 1.32