Hub : Traits :

Long-standing illness, disability or infirmity

10 significantly associated models · 7 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 71163715 73435171 1 1 3.3e-07 1.0e-07 9.4e-03 76 NEGR1
2 1 113608257 115152814 2 1 2.5e-08 1.4e-14 4.6e-08 50 DCLRE1B
3 9 14857740 16758776 1 1 2.8e-07 3.7e-07 3.0e-01 96 CCDC171
4 9 130230514 131620132 1 1 3.2e-07 4.7e-09 3.4e-03 75 C9orf16
5 11 82478824 86036955 2 1 3.8e-08 1.4e-09 1.0e+00 100 AP003026.1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 2.78 1 0 0.0 0.00 1.000 DCLRE1B
Major Depression (MDD) 3.99 2 0 0.0 0.00 1.000 C9orf16 NEGR1
Reaction Time 1.82 1 0 0.0 0.00 1.000 AP003026.1
Breast Cancer 4.22 1 1 3.0 0.00 1.000 DCLRE1B
Body Mass Index (BMI) (2010) 6.56 2 1 3.0 0.00 1.000 CCDC171 NEGR1
Crohns Disease (2012) 1.52 1 0 0.0 0.00 1.000 DCLRE1B
Mean Putamen Volume 5.48 1 1 3.0 0.00 1.000 AP003026.1
Lupus 2.42 1 0 0.0 0.00 1.000 DCLRE1B
Rheumatoid Arthritis 30.91 2 1 3.0 0.00 1.000 CCDC171 DCLRE1B
Schizophrenia 1.03 1 0 0.0 0.00 1.000 AP003026.1
Triglycerides 1.89 1 0 0.0 0.00 1.000 NEGR1
Blood Eosinophil Count 0.58 1 0 0.0 0.00 1.000 DCLRE1B
Blood Platelet Count 0.34 1 0 0.0 0.00 1.000 AP003026.1
Blood White Count 3.09 3 1 3.0 0.00 1.000 AP003026.1 CCDC171 DCLRE1B
Heel T-Score 0.82 2 0 0.0 0.00 1.000 AP003026.1 CCDC171
BMI 7.49 3 2 6.1 0.00 1.000 C9orf16 CCDC171 NEGR1
Height 0.49 2 1 3.0 0.00 1.000 C9orf16 CCDC171
Systolic Blood Pressure 0.98 2 0 0.0 0.00 1.000 C9orf16 NEGR1
Smoking Status 1.50 1 0 0.0 0.00 1.000 DCLRE1B
Allergy or Eczema 1.85 1 0 0.0 0.00 1.000 C9orf16
Cardiovascular Disease 2.39 1 0 0.0 0.00 1.000 NEGR1
Hypothyroidism (self reported) 29.50 1 1 3.0 0.00 1.000 DCLRE1B
Respiratory disease 3.49 2 0 0.0 0.00 1.000 CCDC171 NEGR1
Lung FEV1/FVC ratio 2.04 1 1 3.0 0.00 1.000 CCDC171
Lung FVC 2.59 2 1 3.0 0.00 1.000 CCDC171 DCLRE1B
Neuroticism 2.03 1 0 0.0 0.00 1.000 AP003026.1
Number of treatments/medications taken 5.51 3 0 0.0 0.00 1.000 CCDC171 DCLRE1B NEGR1
Frequency of depressed mood in last 2 weeks 1.59 1 0 0.0 0.00 1.000 AP003026.1
Other serious medical condition/disability diagnosed by doctor 3.56 1 0 0.0 0.00 1.000 DCLRE1B
Vitamin and mineral supplements 2.00 1 0 0.0 0.00 1.000 C9orf16
Pack years adult smoking proportion 1.36 1 0 0.0 0.00 1.000 CCDC171
Impedance of leg (right) 1.09 1 0 0.0 0.00 1.000 NEGR1
Leg fat-free mass (left) 1.13 1 0 0.0 0.00 1.000 NEGR1
Trunk fat percentage 7.99 2 2 6.1 0.00 1.000 CCDC171 NEGR1
Current tobacco smoking 2.06 1 0 0.0 0.00 1.000 DCLRE1B
Maternal smoking around birth 2.41 1 0 0.0 0.00 1.000 CCDC171
Fed-up feelings 1.99 1 0 0.0 0.00 1.000 AP003026.1
Taking other prescription medications 8.99 4 1 3.0 0.97 0.033 AP003026.1 CCDC171 DCLRE1B NEGR1
Age when periods started (menarche) 3.78 2 0 0.0 0.00 1.000 DCLRE1B NEGR1
Bilateral oophorectomy (both ovaries removed) 4.97 1 0 0.0 0.00 1.000 CCDC171
Serious illness, injury or assault to yourself 4.57 2 0 0.0 0.00 1.000 C9orf16 DCLRE1B
High blood pressure 2.30 1 0 0.0 0.00 1.000 NEGR1
Multivitamins +/- minerals 2.28 1 0 0.0 0.00 1.000 C9orf16
Stomach or abdominal pain in last month 3.18 1 0 0.0 0.00 1.000 C9orf16
Medication: Levothyroxine sodium 18.48 1 1 3.0 0.00 1.000 DCLRE1B
Sitting height 1.43 1 1 3.0 0.00 1.000 CCDC171
Body mass index (BMI) 6.73 3 2 6.1 0.00 1.000 C9orf16 CCDC171 NEGR1
Impedance of leg (left) 0.94 1 0 0.0 0.00 1.000 NEGR1
Leg predicted mass (left) 1.13 1 0 0.0 0.00 1.000 NEGR1
Trunk fat mass 6.46 2 2 6.1 0.00 1.000 CCDC171 NEGR1
Waist circumference 4.95 2 2 6.1 0.00 1.000 CCDC171 NEGR1
Past tobacco smoking 4.21 2 0 0.0 0.00 1.000 DCLRE1B NEGR1
Alcohol usually taken with meals 3.14 1 0 0.0 0.00 1.000 DCLRE1B
Frequency of tenseness / restlessness in last 2 weeks 3.26 1 0 0.0 0.00 1.000 C9orf16
Hearing difficulty/problems with background noise 1.78 1 0 0.0 0.00 1.000 C9orf16
Forced vital capacity (FVC) 2.93 1 1 3.0 0.00 1.000 CCDC171
Ever unenthusiastic/disinterested for a whole week 3.51 1 0 0.0 0.00 1.000 C9orf16
Diabetes (self-reported) 3.40 1 0 0.0 0.00 1.000 DCLRE1B
Fluid intelligence score 0.94 1 0 0.0 0.00 1.000 NEGR1
Neuroticism score 1.87 1 0 0.0 0.00 1.000 AP003026.1
Weight 3.62 2 2 6.1 0.00 1.000 CCDC171 NEGR1
Impedance of arm (right) 1.27 1 1 3.0 0.00 1.000 NEGR1
Arm fat percentage (right) 8.18 2 2 6.1 0.00 1.000 CCDC171 NEGR1
Trunk fat-free mass 0.53 1 0 0.0 0.00 1.000 NEGR1
Hip circumference 4.48 2 2 6.1 0.00 1.000 CCDC171 NEGR1
Alcohol intake versus 10 years previously 1.74 1 0 0.0 0.00 1.000 NEGR1
Worrier / anxious feelings 2.28 1 0 0.0 0.00 1.000 AP003026.1
Frequency of tiredness / lethargy in last 2 weeks 3.41 1 0 0.0 0.00 1.000 DCLRE1B
Falls in the last year 3.57 1 0 0.0 0.00 1.000 NEGR1
Forced expiratory volume in 1-second (FEV1) 2.01 1 1 3.0 0.00 1.000 CCDC171
Noisy workplace 2.17 1 0 0.0 0.00 1.000 C9orf16
Qualifications: A levels/AS levels or equivalent 1.07 1 0 0.0 0.00 1.000 CCDC171
Medication: Cholesterol lowering 2.60 1 0 0.0 0.00 1.000 DCLRE1B
Forced expiratory volume in 1-second (FEV1), Best measure 1.26 1 0 0.0 0.00 1.000 CCDC171
Pulse wave Arterial Stiffness index 2.71 1 0 0.0 0.00 1.000 DCLRE1B
Impedance of arm (left) 1.33 1 1 3.0 0.00 1.000 NEGR1
Arm fat mass (right) 6.63 2 2 6.1 0.00 1.000 CCDC171 NEGR1
Trunk predicted mass 0.51 1 0 0.0 0.00 1.000 NEGR1
Standing height 0.60 2 0 0.0 0.00 1.000 C9orf16 CCDC171
Seen doctor (GP) for nerves, anxiety, tension or depression 3.02 1 0 0.0 0.00 1.000 NEGR1
Birth weight of first child 3.02 1 0 0.0 0.00 1.000 DCLRE1B
Mouth/teeth dental problems: Bleeding gums 3.22 1 0 0.0 0.00 1.000 DCLRE1B
Medication: Paracetamol 1.71 1 0 0.0 0.00 1.000 CCDC171
Medication for cholesterol, blood pressure or diabetes 2.73 2 0 0.0 0.00 1.000 DCLRE1B NEGR1
Hypothyroidism/myxoedema (self-reported) 25.28 1 1 3.0 0.00 1.000 DCLRE1B
Birth weight 0.98 1 0 0.0 0.00 1.000 DCLRE1B
Forced vital capacity (FVC), Best measure 2.29 1 1 3.0 0.00 1.000 CCDC171
Body fat percentage 9.10 2 2 6.1 0.00 1.000 CCDC171 NEGR1
Leg fat percentage (right) 9.60 2 2 6.1 0.00 1.000 CCDC171 NEGR1
Arm fat-free mass (right) 1.05 1 0 0.0 0.00 1.000 NEGR1
Comparative body size at age 10 3.21 1 1 3.0 0.00 1.000 NEGR1
Worry too long after embarrassment 3.89 2 0 0.0 0.00 1.000 C9orf16 DCLRE1B
Wheeze or whistling in the chest in last year 5.27 2 0 0.0 0.00 1.000 AP003026.1 CCDC171
Age at first live birth 1.62 1 0 0.0 0.00 1.000 CCDC171
Health satisfaction 4.36 1 0 0.0 0.00 1.000 AP003026.1
Shortness of breath walking on level ground 3.48 1 0 0.0 0.00 1.000 AP003026.1
Qualifications: College or University degree 1.87 1 0 0.0 0.00 1.000 NEGR1
Medication for pain relief, constipation, heartburn 1.88 1 0 0.0 0.00 1.000 CCDC171
Medication: Omeprazole 4.09 2 0 0.0 0.00 1.000 AP003026.1 CCDC171
Mean time to correctly identify matches 1.75 1 0 0.0 0.00 1.000 DCLRE1B
Whole body fat mass 6.92 2 2 6.1 0.00 1.000 CCDC171 NEGR1
Leg fat mass (right) 7.55 2 2 6.1 0.00 1.000 CCDC171 NEGR1
Arm predicted mass (right) 0.96 1 0 0.0 0.00 1.000 NEGR1
Pulse rate, automated reading 2.44 2 0 0.0 0.00 1.000 CCDC171 NEGR1
Alcohol intake frequency. 2.23 1 0 0.0 0.00 1.000 DCLRE1B
Overall health rating 5.23 3 0 0.0 0.00 1.000 AP003026.1 C9orf16 DCLRE1B
Commuting to job workplace: Car/motor vehicle 4.06 1 0 0.0 0.00 1.000 C9orf16
Hypertension (Self-reported) 2.08 1 0 0.0 0.00 1.000 NEGR1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.39 1 0 0.0 0.00 1.000 C9orf16
Smoking status: Previous 4.61 2 0 0.0 0.00 1.000 DCLRE1B NEGR1
Whole body fat-free mass 0.69 1 0 0.0 0.00 1.000 NEGR1
Leg fat-free mass (right) 1.00 1 0 0.0 0.00 1.000 NEGR1
Arm fat percentage (left) 8.48 2 2 6.1 0.00 1.000 CCDC171 NEGR1
Mood swings 1.64 1 0 0.0 0.00 1.000 AP003026.1
Loneliness, isolation 1.89 1 0 0.0 0.00 1.000 AP003026.1
Diabetes diagnosed by doctor 2.94 1 0 0.0 0.00 1.000 DCLRE1B
Mineral and other dietary supplements 2.38 1 0 0.0 0.00 1.000 CCDC171
Osteoarthritis (self-reported) 2.56 1 0 0.0 0.00 1.000 CCDC171
Illnesses of father: None of the above (group 1) 2.08 1 0 0.0 0.00 1.000 AP003026.1
Whole body water mass 0.72 1 0 0.0 0.00 1.000 NEGR1
Leg predicted mass (right) 1.02 1 0 0.0 0.00 1.000 NEGR1
Arm fat mass (left) 6.86 2 2 6.1 0.00 1.000 CCDC171 NEGR1
Number of self-reported non-cancer illnesses 4.01 1 0 0.0 0.00 1.000 NEGR1
Mother's age at death 2.56 1 0 0.0 0.00 1.000 AP003026.1
Financial situation satisfaction 1.83 1 0 0.0 0.00 1.000 CCDC171
Pain type(s) experienced in last month: Hip pain 4.22 2 0 0.0 0.00 1.000 AP003026.1 CCDC171
Medication: Paracetamol 2.62 2 0 0.0 0.00 1.000 C9orf16 CCDC171
Ever smoked 4.48 2 0 0.0 0.00 1.000 CCDC171 DCLRE1B
Basal metabolic rate 1.13 1 0 0.0 0.00 1.000 NEGR1
Leg fat percentage (left) 10.16 2 2 6.1 0.00 1.000 CCDC171 NEGR1
Arm fat-free mass (left) 1.19 1 1 3.0 0.00 1.000 NEGR1
Number of operations (self-reported) 2.40 1 0 0.0 0.00 1.000 NEGR1
Irritability 2.44 1 0 0.0 0.00 1.000 NEGR1
Risk taking 3.74 1 0 0.0 0.00 1.000 CCDC171
Diastolic blood pressure, automated reading 1.71 2 0 0.0 0.00 1.000 AP003026.1 CCDC171
Unable to work because of sickness or disability 3.61 1 0 0.0 0.00 1.000 AP003026.1
Myopia 2.19 1 0 0.0 0.00 1.000 CCDC171
Vascular/heart problems diagnosed by doctor 2.40 2 0 0.0 0.00 1.000 AP003026.1 NEGR1
Cholesterol lowering medication 1.38 1 0 0.0 0.00 1.000 CCDC171
Heart attack/myocardial infarction (self-reported) 1.88 1 0 0.0 0.00 1.000 DCLRE1B
Impedance of whole body 1.20 1 0 0.0 0.00 1.000 NEGR1
Leg fat mass (left) 7.78 2 2 6.1 0.00 1.000 CCDC171 NEGR1
Arm predicted mass (left) 1.25 1 1 3.0 0.00 1.000 NEGR1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.62
GTEx Adipose Visceral Omentum 0 0.0000 1.54
GTEx Adrenal Gland 0 0.0000 1.47
GTEx Artery Aorta 0 0.0000 1.63
GTEx Artery Coronary 0 0.0000 1.52
GTEx Artery Tibial 0 0.0000 1.57
GTEx Brain Caudate basal ganglia 0 0.0000 1.49
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.58
GTEx Brain Cerebellum 1 0.0505 1.64
GTEx Brain Cortex 0 0.0000 1.72
GTEx Brain Frontal Cortex BA9 0 0.0000 1.57
GTEx Brain Hippocampus 0 0.0000 1.54
GTEx Brain Hypothalamus 0 0.0000 1.62
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.46
GTEx Brain Putamen basal ganglia 0 0.0000 1.56
GTEx Breast Mammary Tissue 1 0.0507 1.61
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.46
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.54
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.66
GTEx Cells Transformed fibroblasts 0 0.0000 1.59
GTEx Colon Sigmoid 0 0.0000 1.57
GTEx Colon Transverse 0 0.0000 1.60
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.52
GTEx Esophagus Mucosa 0 0.0000 1.62
GTEx Esophagus Muscularis 1 0.0309 1.54
GTEx Heart Atrial Appendage 0 0.0000 1.57
GTEx Heart Left Ventricle 0 0.0000 1.61
GTEx Liver 0 0.0000 1.53
GTEx Lung 0 0.0000 1.53
GTEx Muscle Skeletal 0 0.0000 1.58
GTEx Nerve Tibial 0 0.0000 1.58
GTEx Ovary 0 0.0000 1.69
GTEx Pancreas 0 0.0000 1.53
GTEx Pituitary 0 0.0000 1.58
GTEx Prostate 0 0.0000 1.50
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.69
GTEx Skin Sun Exposed Lower leg 2 0.0549 1.65
GTEx Small Intestine Terminal Ileum 0 0.0000 1.47
GTEx Spleen 0 0.0000 1.55
GTEx Stomach 0 0.0000 1.57
GTEx Testis 1 0.0317 1.56
GTEx Thyroid 0 0.0000 1.59
GTEx Uterus 0 0.0000 1.43
GTEx Vagina 0 0.0000 1.53
GTEx Whole Blood 0 0.0000 1.61
METSIM Adipose 0 0.0000 1.48
NTR Blood 0 0.0000 1.51
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.53
YFS Blood 0 0.0000 1.49
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.56
TCGA Breast Tumor 0 0.0000 1.65
TCGA Breast Normal 2 0.0475 1.44
TCGA Ovarian Tumor 0 0.0000 1.46
TCGA Prostate Tumor 0 0.0000 1.48