Hub : Genes

ZYX

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0993	0.0419	2.9e-03	0.032	NA	0.040	NA	0.039	1.5e-03	NA	4.1e-04	NA	5.1e-04
2	GTEx	Skin Not Sun Exposed Suprapubic	0.1600	0.0580	3.3e-03	-0.005	NA	0.000	NA	-0.005	9.9e-01	NA	3.4e-01	NA	8.3e-01
3	GTEx	Whole Blood	0.3070	0.0500	2.4e-11	0.210	NA	0.224	NA	0.220	4.2e-19	NA	2.1e-20	NA	4.6e-20
4	METSIM	Adipose	0.2020	0.0505	6.0e-07	0.007	0.063	0.068	0.068	0.038	3.0e-02	1.0e-09	1.8e-10	2.2e-10	2.1e-06
5	NTR	Blood	0.0897	0.0224	2.1e-07	0.053	0.034	0.049	0.050	0.050	1.0e-16	3.2e-11	2.3e-15	6.7e-16	9.2e-16
6	YFS	Blood	0.6868	0.0291	0.0e+00	0.274	0.462	0.490	0.470	0.487	4.1e-90	2.8e-172	4.4e-187	2.5e-176	3.8e-185
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0654	0.0290	9.6e-03	-0.002	0.020	0.002	NA	0.001	7.1e-01	2.1e-03	1.6e-01	NA	2.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.2	0.2	0.7	0.2	0.5	0.3	0.6	-0.2	-0.4	0.8
Bipolar Disorder or Schizophrenia	0.5	1.2	6.5	-0.2	-0.5	-0.4	1.0	-0.5	-0.4	2.5
Depressed Affect (Nagel 2018)	1.7	3.7	7.7	-2.0	2.8	-1.8	1.1	-2.1	-1.2	2.0
Depression (Nagel 2018)	2.1	3.2	6.1	-2.5	2.5	-2.1	0.7	-2.0	-1.0	0.4
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.4	0.2	0.4	0.0	0.2	0.6	0.4	0.3
Neuroticism (Nagel 2018)	2.6	6.2	11.6	-2.9	1.6	-3.2	0.0	-3.4	-2.9	1.6
Schizophrenia (2018)	0.6	1.3	7.4	-0.4	-0.8	-0.8	0.5	-0.4	-0.3	2.7
Schizophrenia vs Biploar Disorder	0.6	0.8	2.8	0.1	0.2	-0.7	-1.7	-1.0	-0.2	-1.2
Worry (Nagel 2018)	1.5	3.3	6.0	-1.6	1.6	-2.2	-0.8	-2.3	-2.4	1.2
Alzheimer’s Disease (in mother)	2.6	3.1	7.5	2.3	-1.4	1.6	-1.8	1.1	0.6	-2.7
Alzheimer’s Disease (in father)	1.8	2.0	7.6	-0.7	-2.8	-0.5	-1.0	-0.5	-1.5	-1.4
Alzheimer’s Disease (including proxy)	7.8	11.4	32.3	2.6	-4.7	1.9	-3.6	1.3	-0.1	-5.7
Crohns Disease (2017)	0.5	1.0	2.8	-1.7	1.4	-0.8	0.6	-1.0	-0.7	0.2
Irritable Bowel Disease (IBD)	0.6	1.4	3.1	-1.7	1.0	-1.3	0.3	-1.5	-1.2	0.5
Ulcerative Colitis (UC)	0.3	0.5	1.0	-0.7	0.1	-0.9	0.1	-1.0	-0.8	0.7
Major Depression (MDD)	0.8	1.0	1.8	-0.3	-1.2	-0.9	-0.1	-1.3	-1.2	1.3
Reaction Time	0.7	1.3	2.9	0.3	-0.4	1.4	0.8	1.7	1.4	-1.1
Verbal and Numeric Reasoning (VNR)	1.1	2.7	6.1	2.0	0.5	1.0	2.1	1.6	1.0	2.5
Breast Cancer	0.9	2.1	4.4	1.5	0.4	1.6	0.8	2.1	1.8	-1.1
Ovarian Cancer	1.3	1.7	6.9	-0.1	0.1	0.0	-2.2	0.0	0.0	-2.6
Prostate Cancer	0.8	1.1	2.7	0.0	-0.5	-1.4	-1.0	-1.4	-1.6	-0.4
Age at First Birth	1.9	2.8	6.8	-1.4	-1.1	-2.6	-0.3	-2.1	-1.3	-1.8
Bipolar Disorder (2011)	1.3	1.2	3.7	-1.4	0.0	-1.7	0.0	-1.9	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	1.9	0.7	0.0	-0.7	-1.4	-0.8	-1.2	0.2
Coronary Artery Disease (CAD)	0.3	0.4	0.8	0.9	0.1	0.7	0.7	0.9	0.3	0.0
Crohns Disease (2012)	1.5	2.5	5.2	-2.3	2.1	-1.8	-0.3	-1.6	-1.3	-0.2
Mean Putamen Volume	0.5	0.6	1.0	1.0	0.6	0.8	-0.5	0.8	0.6	-0.9
Fasting Glucose	0.2	0.2	1.1	0.7	-0.2	-0.1	1.0	0.3	-0.1	0.2
HbA1C	0.0	0.0	0.0	-0.1	-0.1	0.1	0.1	-0.1	-0.1	0.2
HDL Cholesterol	0.3	0.5	1.3	0.0	-0.7	-0.2	-1.1	-0.2	-0.7	-1.1
LDL Cholesterol	0.9	1.5	4.0	1.0	-1.5	-0.0	-2.0	0.0	-0.7	-1.6
Lupus	0.1	0.1	0.6	-0.1	0.3	0.0	-0.8	-0.1	-0.2	-0.5
Neuroticism (2016)	1.6	2.3	5.8	-2.4	-0.2	-1.3	-0.8	-2.0	-1.6	-1.0
Primary Biliary Cirrhosis	0.6	0.8	4.9	-0.6	-2.2	0.2	0.3	0.2	0.3	-0.5
Rheumatoid Arthritis	0.9	1.2	1.9	0.7	-1.1	1.4	1.1	1.3	1.2	-0.9
Schizophrenia (2014)	0.6	1.3	5.2	-0.5	-0.6	-1.4	0.1	-0.8	-0.8	2.3
Triglycerides	0.3	0.5	1.1	0.8	-1.0	0.7	-0.6	0.4	0.5	0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.7	-0.8	-0.3	-0.4	-0.3	-0.2	-0.1	-0.8
Ulcerative Colitis	0.3	0.4	1.9	-1.4	-0.2	-0.7	-0.0	0.0	-0.2	0.0
Blood Eosinophil Count	0.7	5.7	9.9	-1.9	0.3	-2.9	-1.0	-3.1	-3.0	-2.8
Blood Platelet Count	0.2	2.1	4.6	0.5	2.1	-1.5	1.9	-0.9	0.8	1.7
Blood Red Count	0.2	1.7	6.9	-0.2	-2.6	-0.5	-1.7	-0.3	-0.2	-1.3
Blood White Count	0.6	4.4	8.2	-1.1	-0.9	-2.9	-2.4	-2.8	-2.3	-1.2
Heel T-Score	0.8	6.5	14.4	2.9	-1.9	3.8	-0.4	3.5	2.6	0.4
BMI	0.1	0.4	1.5	-0.1	0.1	-0.3	-1.2	-0.4	-0.3	-0.8
Height	0.0	0.5	1.7	-0.6	0.3	-0.1	-1.3	0.2	-0.6	-0.9
Waist Hip Ratio (WHR)	0.3	1.2	3.5	-0.1	1.9	0.1	1.1	0.7	1.1	1.5
Systolic Blood Pressure	0.1	0.6	2.2	-1.5	-0.9	-0.6	0.2	-0.8	-0.7	-0.1
Smoking Status	0.1	0.3	1.0	1.0	0.5	-0.0	0.2	-0.3	0.2	0.9
Allergy or Eczema	0.3	0.8	4.3	-0.5	0.0	0.1	1.1	0.3	-0.4	2.1
Cardiovascular Disease	0.0	0.1	0.5	-0.6	-0.7	-0.2	-0.3	0.1	0.1	-0.2
Hypothyroidism (self reported)	0.5	1.2	4.2	-0.0	-0.3	-0.6	-1.5	-0.9	-0.7	-2.1
Respiratory disease	0.4	1.0	3.4	-1.8	0.7	-0.7	0.5	-1.2	-0.1	-0.8
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.2	1.3	-0.3	1.5	0.2	1.3	1.5	0.1
Lung FEV1/FVC ratio	0.6	2.9	7.8	0.4	-2.1	0.7	2.4	0.8	1.1	2.8
Lung FVC	0.3	1.4	3.7	1.2	0.4	1.6	1.9	0.7	1.1	0.6
Neuroticism	2.2	5.4	10.6	-2.6	1.8	-2.7	0.1	-3.3	-2.5	1.9
Chronotype (morning person)	0.6	1.4	2.7	-0.7	0.9	1.1	1.6	1.0	1.5	-0.9
Hair Pigment	0.1	3.3	6.6	1.7	-1.8	2.6	0.2	1.3	1.6	-2.5
Tanning	0.0	0.5	0.9	0.7	-0.9	-0.3	-0.8	-0.5	-1.0	-0.7
Hand grip strength (left)	0.9	2.5	5.0	-0.7	0.4	-1.9	-1.9	-2.1	-2.2	0.2
Number of treatments/medications taken	0.1	0.1	0.4	0.6	0.4	0.1	0.3	-0.2	-0.2	0.3
Average weekly spirits intake	0.7	0.8	2.5	-1.6	-0.9	-1.0	-1.0	-0.5	-0.4	-0.3
Sensitivity / hurt feelings	0.9	1.5	2.9	-1.6	-0.3	-1.5	1.0	-1.7	-1.3	0.5
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.7	-0.6	0.1	-0.6	0.1	-0.8	-0.4	0.2
Hearing difficulty/problems: Yes	0.6	0.9	2.2	0.9	1.5	0.8	1.2	0.2	1.0	-0.6
Relative age of first facial hair	0.3	0.5	1.8	-0.2	1.1	-0.6	1.3	0.0	0.5	-0.4
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	5.2	-0.3	-1.1	-0.7	-2.3	-0.8	-0.7	-1.9
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.4	-0.2	-0.1	-0.1	1.2	0.1	0.7	0.6
Ever had hysterectomy (womb removed)	0.6	0.7	2.9	-1.1	1.7	0.1	-0.1	0.2	0.4	-0.6
Systolic blood pressure, automated reading	0.3	1.0	3.3	-1.8	-0.8	-0.8	0.5	-0.7	-0.7	-1.1
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	4.3	-1.6	1.7	-0.5	1.2	-0.2	0.2	2.1
Angina	0.3	0.4	0.8	-0.5	-0.2	0.9	0.1	0.6	0.8	0.6
Medication for hormone replacement therapy	0.1	0.1	0.3	0.1	0.3	0.3	0.3	-0.2	-0.2	0.5
Vitamin and mineral supplements	0.7	1.0	3.2	0.3	-0.8	0.4	-1.5	0.8	0.3	-1.8
Supplements: Zinc	0.6	0.7	1.5	0.4	0.4	-0.6	-0.7	-1.2	-1.2	-0.9
Medication: Co-codamol	0.3	0.4	1.1	-1.0	0.9	0.2	-0.3	0.2	0.4	-0.6
Medication: Metformin	0.3	0.5	1.1	-0.4	-0.1	0.7	-0.8	0.5	0.9	-1.0
Diabetes (father)	1.7	2.1	3.9	0.9	0.4	-1.2	-1.6	-1.7	-2.0	-1.5
Diabetes (mother)	2.1	2.7	8.3	-2.7	2.9	-1.2	1.0	-1.0	-0.3	0.4
Severe depression (siblings)	0.7	0.8	3.3	0.0	1.8	-0.5	0.0	-1.1	-1.0	0.1
Pack years adult smoking proportion	0.8	1.2	1.8	1.3	-1.2	1.3	0.8	1.0	0.8	1.1
Impedance of leg (right)	0.2	0.8	3.1	0.3	1.0	0.0	1.8	0.6	0.9	0.1
Leg fat-free mass (left)	0.3	1.5	6.5	-0.1	-1.4	0.4	-2.5	0.1	-0.7	-1.1
Trunk fat percentage	0.2	0.9	2.8	-0.4	-0.1	-0.5	-1.6	-0.6	-0.5	-1.7
Hand grip strength (right)	1.4	3.8	7.8	-0.7	0.8	-2.7	-1.7	-2.7	-2.8	-0.2
Townsend deprivation index at recruitment	5.9	8.3	15.2	3.9	-1.5	3.5	2.4	3.3	3.3	1.3
Current tobacco smoking	1.4	2.2	4.6	2.1	-1.3	1.1	1.2	1.2	1.1	2.0
Average weekly fortified wine intake	2.3	2.7	4.1	2.0	-0.8	1.7	1.7	1.9	1.6	1.6
Maternal smoking around birth	0.1	0.1	0.3	-0.1	-0.0	0.2	-0.5	0.5	0.3	-0.3
Fed-up feelings	0.9	1.7	4.1	-1.2	1.0	-1.3	0.6	-1.7	-0.9	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	4.4	-2.1	1.5	-0.6	1.4	-0.4	0.7	0.6
Relative age voice broke	0.1	0.2	0.8	-0.9	0.4	-0.4	0.6	0.1	0.3	-0.1
Taking other prescription medications	0.4	0.6	1.5	-0.2	0.9	0.2	1.1	0.1	0.6	1.2
Age when periods started (menarche)	0.4	1.1	3.2	0.9	0.4	0.1	-1.8	0.3	-0.5	-1.7
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.0	1.2	0.1	1.4	-0.2	1.1	1.1	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	2.2	0.4	-0.7	-0.4	-1.5	-0.8	-1.0	0.1
Tinnitus: Yes, but not now, but have in the past	1.5	1.7	5.4	-0.2	-2.3	1.2	0.1	1.4	1.6	0.2
Qualifications: CSEs or equivalent	0.7	1.0	5.2	0.5	-0.0	0.6	-0.0	0.3	1.0	-2.3
Serious illness, injury or assault to yourself	0.8	1.0	2.5	-1.1	0.2	-1.6	-0.6	-1.4	-1.1	-0.1
High blood pressure	0.3	0.8	1.7	-0.9	0.7	-1.2	-0.1	-1.3	-1.0	0.5
Hayfever, allergic rhinitis or eczema	0.2	0.5	2.4	0.2	0.2	-0.2	0.6	0.2	-0.6	1.6
Multivitamins +/- minerals	1.2	1.5	3.6	-1.4	1.4	-0.4	1.8	-0.3	0.2	1.9
Stomach or abdominal pain in last month	1.6	2.0	4.5	-1.7	0.2	-1.9	1.3	-2.1	-0.9	0.4
Supplements: Glucosamine	0.1	0.1	0.4	-0.6	0.3	0.0	-0.1	0.0	-0.1	0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.6	-0.8	-0.0	-0.7	0.0	-0.6	-0.5	0.6
Medication: Atenolol	0.6	0.8	3.1	-0.2	-1.8	0.5	-1.1	-0.2	-0.3	-0.9
Medication: Levothyroxine sodium	0.3	0.5	1.1	0.3	0.7	1.0	0.4	0.6	1.0	-0.7
Sitting height	0.0	0.1	0.4	-0.5	-0.6	0.3	-0.2	0.3	0.2	-0.1
Chronic bronchitis/emphysema (father)	1.0	1.2	6.2	0.3	2.5	0.0	0.3	-0.7	-0.8	-0.8
High blood pressure (mother)	1.2	1.6	2.4	-1.5	1.5	-1.3	0.5	-1.2	-0.9	1.5
Body mass index (BMI)	0.2	0.8	3.4	0.3	-1.0	-0.1	-1.9	-0.6	-0.5	-0.9
Impedance of leg (left)	0.1	0.6	2.1	0.2	1.2	-0.2	1.4	0.4	0.9	-0.2
Leg predicted mass (left)	0.3	1.6	6.9	-0.0	-1.5	0.5	-2.6	0.1	-0.7	-1.3
Trunk fat mass	0.2	0.8	3.2	-0.3	-0.4	-0.3	-1.8	-0.4	-0.4	-1.3
Waist circumference	0.1	0.4	0.9	0.4	0.1	0.9	-0.8	0.7	0.7	-0.1
Number of incorrect matches in round	0.8	1.4	2.9	-1.6	1.5	0.5	1.7	0.0	0.2	1.4
Past tobacco smoking	0.3	0.6	1.3	0.6	-0.7	1.0	-0.9	1.1	0.3	-0.6
Alcohol usually taken with meals	0.2	0.4	2.0	0.1	-1.4	0.2	0.4	0.1	-0.0	-0.6
Nervous feelings	0.4	0.8	5.0	-0.5	0.1	-0.0	0.6	0.1	0.2	2.2
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	4.7	-1.3	0.3	-1.5	-0.8	-2.2	-1.5	0.3
Hearing difficulty/problems with background noise	0.5	0.8	4.1	0.5	2.0	0.5	0.3	0.2	0.4	-0.8
Hair/balding pattern: Pattern 2	1.6	2.0	3.1	-1.7	1.8	-1.7	0.2	-1.5	-1.7	0.3
Had menopause	1.2	1.5	2.4	-0.6	-1.6	-1.3	-1.0	-1.6	-1.5	-0.5
Had other major operations	1.9	2.4	3.7	0.2	1.9	1.7	1.9	1.2	1.1	1.9
Forced vital capacity (FVC)	0.2	0.7	1.7	0.6	0.2	1.2	0.8	0.6	0.6	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.0	0.9	-0.7	0.7	-1.0	0.4	0.5	0.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.1	0.6	-0.4	0.0	1.1	-0.1	0.6	1.4
Qualifications: None of the above	0.5	1.0	2.6	0.3	1.6	0.9	-0.5	1.0	0.6	-1.3
Financial difficulties in last 2 years	0.5	0.6	1.2	-0.1	0.9	-0.9	-0.7	-1.1	-1.0	0.4
Mouth/teeth dental problems	1.0	1.5	4.0	-1.3	1.2	0.5	0.9	1.2	2.0	0.9
Heart attack	0.9	1.1	3.4	1.8	-0.8	1.5	-0.1	0.6	0.9	0.5
Allergy	0.5	1.2	3.6	0.5	-1.3	0.8	-0.7	0.9	0.9	-1.9
Pain all over the body in last month	0.3	0.3	1.2	0.4	-0.2	-0.1	-0.5	-0.5	-1.1	0.4
Diabetes (self-reported)	0.6	0.9	2.7	0.7	-0.2	1.6	-0.1	1.1	1.3	-0.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.7	-0.2	-0.8	0.6	0.8	0.7	0.3	1.3
Medication: Ramipril	1.5	1.9	5.4	0.9	1.1	1.0	2.3	1.0	1.1	1.6
Medication: Simvastatin	1.5	2.2	3.3	1.3	-1.6	1.8	-0.5	1.5	1.7	-1.4
Fluid intelligence score	0.2	0.4	1.4	1.1	0.0	-0.1	0.3	0.4	0.1	1.2
Illnesses of siblings	2.1	2.9	6.0	-0.3	-2.0	-2.0	-1.1	-2.1	-2.4	0.7
Neuroticism score	2.2	4.5	9.6	-2.4	0.9	-2.8	0.1	-3.1	-2.3	1.6
Weight	0.2	1.0	4.0	0.1	-1.3	0.1	-2.0	-0.2	-0.4	-1.0
Impedance of arm (right)	0.1	0.5	1.4	-0.4	1.1	-0.3	0.8	0.3	0.3	-1.2
Arm fat percentage (right)	0.1	0.5	1.4	-0.4	0.4	-0.4	-1.2	-0.6	-0.4	-1.1
Trunk fat-free mass	0.1	0.4	1.4	-0.0	-1.0	0.4	-1.2	0.2	-0.1	0.3
Hip circumference	0.1	0.5	2.2	-0.2	-0.7	-0.1	-1.5	-0.3	-0.5	-0.7
Time employed in main current job	0.7	0.8	2.6	-1.6	1.6	-0.3	0.1	-0.4	0.0	0.6
Alcohol intake versus 10 years previously	1.5	2.3	4.8	0.1	-0.9	2.0	0.7	2.2	2.1	-1.2
Father’s age at death	1.3	1.8	4.8	-0.2	-0.3	-1.2	-2.2	-1.1	-2.1	-0.8
Worrier / anxious feelings	1.2	2.2	4.1	-2.0	0.8	-1.5	1.0	-2.0	-1.1	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.0	-0.3	0.5	-0.9	-0.6	-1.0	-0.3	-0.1
Falls in the last year	0.4	0.6	3.7	-0.1	0.3	0.2	1.9	-0.1	0.0	0.2
Hair/balding pattern: Pattern 3	1.8	2.7	7.9	2.8	-0.5	2.1	-0.1	1.8	1.5	1.1
Number of live births	0.7	1.0	3.5	-1.9	1.1	-0.1	1.1	0.7	0.8	-0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.4	0.0	0.1	0.8	0.7	0.2	0.4	-1.2
Pulse rate	1.4	2.4	4.4	-1.5	1.8	-2.1	0.0	-2.0	-1.4	1.0
Happiness	0.2	0.3	0.7	-0.6	0.5	0.1	0.6	0.3	0.6	0.8
Noisy workplace	0.7	0.8	3.1	0.0	1.8	0.9	0.1	0.4	1.3	-0.5
Qualifications: A levels/AS levels or equivalent	0.6	1.4	6.1	0.1	1.7	-0.6	-0.4	0.1	-0.4	2.5
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	3.2	-0.1	-0.7	0.4	0.5	0.3	1.0	1.8
Mouth/teeth dental problems: Dentures	0.3	0.5	1.2	0.0	0.2	-0.9	-0.7	-0.8	-1.1	0.4
Asthma	0.3	0.5	1.4	-1.2	0.4	-0.3	1.0	-0.9	0.1	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.5	-0.5	-0.2	0.0	0.1	0.5	-0.2
Medication: Cholesterol lowering	0.3	0.4	1.2	0.4	-0.0	0.5	-1.1	0.6	0.4	-0.9
Depression (self-reported)	1.4	1.7	7.7	0.1	-0.5	0.1	2.8	0.3	0.8	1.8
Medication: Lansoprazole	0.8	0.9	2.8	0.4	0.6	-1.1	-0.5	-1.7	-0.9	0.7
Prospective memory result	1.2	1.4	6.9	-2.6	1.2	-0.7	0.2	-0.7	-0.2	-0.8
Lung cancer (father)	2.1	2.5	3.8	1.2	-1.8	1.9	2.0	1.0	1.9	0.9
Illnesses of mother	1.1	1.3	4.8	2.2	-1.4	1.1	-0.3	0.9	0.4	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.7	0.1	0.3	0.9	0.1	0.2	0.3	-0.6
Pulse wave Arterial Stiffness index	0.6	0.7	2.7	-0.4	1.6	-0.0	0.0	-0.2	-0.3	1.3
Impedance of arm (left)	0.1	0.4	1.1	-0.0	1.0	-0.1	0.7	0.4	0.1	-1.0
Arm fat mass (right)	0.2	0.8	2.6	-0.5	-0.2	-0.5	-1.6	-0.7	-0.6	-1.1
Trunk predicted mass	0.1	0.4	1.7	0.0	-1.0	0.5	-1.3	0.2	-0.1	0.3
Standing height	0.0	0.2	0.4	-0.7	-0.6	0.2	-0.4	0.6	0.0	-0.2
Length of working week for main job	1.3	1.4	3.0	-0.7	-0.4	-1.1	-1.0	-1.4	-1.3	-1.7
Exposure to tobacco smoke at home	0.2	0.2	0.7	0.4	-0.7	-0.1	-0.0	-0.4	-0.1	0.8
Breastfed as a baby	2.8	3.5	5.9	2.0	-0.9	2.1	1.1	2.4	2.1	1.8
Tense / ‘highly strung’	3.7	6.2	13.5	-2.1	1.6	-3.2	-1.4	-3.7	-3.2	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	5.1	-1.2	0.7	-1.3	1.3	-1.3	-0.9	2.2
Hair/balding pattern: Pattern 4	0.2	0.4	1.2	-0.6	-0.4	-0.2	-1.1	-0.3	-0.7	-0.4
Birth weight of first child	0.7	1.2	2.2	-1.5	1.1	-1.5	0.7	-1.1	-0.8	-0.7
Peak expiratory flow (PEF)	0.8	1.9	2.9	-1.2	1.7	-1.2	1.6	-1.5	-1.5	0.6
Pulse wave reflection index	0.8	1.0	2.0	-0.1	1.3	1.4	0.4	1.2	1.1	0.7
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.3	0.4	-1.2	-0.0	-1.5	-0.6	-0.8	-1.5
Loud music exposure frequency	0.9	1.0	3.8	0.0	0.4	0.6	2.0	0.6	0.7	1.3
Qualifications: O levels/GCSEs or equivalent	3.4	5.4	10.6	-2.2	0.9	-3.3	-2.3	-2.4	-3.0	1.2
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.1	0.5	-1.7	-0.5	-1.0	-1.2	-1.8	-0.8
Blood clot in the leg (DVT)	0.3	0.4	0.9	-0.9	0.7	-0.5	-0.4	-0.8	-0.1	-0.6
Medication: Paracetamol	0.3	0.4	1.3	-0.1	1.2	-0.7	0.4	-0.7	-0.6	0.4
Headache pain in last month	0.8	1.3	3.9	-0.9	-0.1	-1.7	-0.2	-2.0	-0.8	-1.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.6	-0.3	0.7	-0.5	1.3	-0.7	-0.7	0.7
Glaucoma (self-reported)	0.7	0.8	1.9	-1.4	1.0	-0.9	-0.9	-0.9	-0.6	-0.4
Gout (self-reported)	0.4	0.5	1.3	-0.6	-0.5	0.8	-0.3	1.1	0.9	-0.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	3.2	0.0	-0.6	-1.1	-1.3	-1.4	-1.1	-1.8
Medication: Amlodipine	0.3	0.4	1.3	-0.1	-0.6	-0.7	-1.1	-0.4	-0.1	-0.6
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.1	-1.3	0.1	-0.9	-1.4	-1.2	-0.8	0.1
Birth weight	0.4	0.8	2.1	-0.6	0.2	1.2	0.3	1.3	1.5	-0.0
Chronic bronchitis/emphysema (mother)	0.2	0.2	1.0	0.3	0.1	0.2	1.0	-0.5	-0.4	0.1
High blood pressure (siblings)	1.3	1.9	3.7	1.1	1.1	1.8	1.0	1.7	1.9	0.2
Forced vital capacity (FVC), Best measure	0.1	0.2	0.8	0.2	0.4	0.5	-0.2	-0.2	-0.1	-0.9
Body fat percentage	0.2	0.7	2.4	-0.2	0.1	-0.3	-1.5	-0.5	-0.4	-1.6
Leg fat percentage (right)	0.1	0.3	0.9	0.4	-0.4	0.4	-0.8	0.2	0.3	-0.9
Arm fat-free mass (right)	0.2	1.0	4.4	-0.3	-1.5	-0.1	-2.1	-0.3	-0.7	0.1
Exposure to tobacco smoke outside home	0.2	0.3	1.0	0.5	0.4	0.2	1.0	-0.2	0.5	0.2
Comparative body size at age 10	0.7	1.9	6.2	0.5	-2.5	1.3	-0.9	1.0	0.9	-1.5
Number of full brothers	0.5	0.6	1.6	0.9	0.5	0.6	-1.3	0.6	0.1	-0.7
Worry too long after embarrassment	2.0	3.3	7.0	-2.3	0.2	-2.7	0.1	-2.5	-1.8	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	3.7	-1.4	-0.8	-1.3	1.6	-0.8	-0.7	1.9
Wheeze or whistling in the chest in last year	0.2	0.3	1.2	-0.1	1.1	-0.3	0.6	-0.7	-0.4	0.3
Number of children fathered	0.6	0.7	1.5	-0.9	1.2	-0.8	-0.2	-0.3	-0.7	1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.5	-0.9	1.1	-1.1	-0.5	-1.5	-1.6	-0.0
Age at first live birth	0.2	0.4	1.4	0.9	-1.2	0.1	-0.0	0.2	-0.5	0.2
Pulse wave peak to peak time	0.7	0.8	3.3	0.5	-1.8	0.0	0.0	0.3	0.2	-1.4
Health satisfaction	0.2	0.2	0.7	0.5	-0.2	0.7	0.4	0.0	0.1	-0.8
Shortness of breath walking on level ground	0.5	0.6	2.0	1.4	-0.4	0.7	-0.9	0.8	0.4	0.1
Qualifications: College or University degree	0.1	0.5	1.3	0.1	-0.4	-0.8	-0.6	-0.7	-1.2	0.4
Eye problems/disorders: None of the above	0.7	0.8	4.3	2.1	-0.4	0.1	0.9	0.2	-0.0	0.3
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.9	1.0	0.3	-0.6	-0.5	-0.8	-0.7	0.9
Emphysema/chronic bronchitis	0.1	0.1	0.4	-0.6	-0.0	0.1	-0.6	-0.1	0.3	-0.4
Medication for pain relief, constipation, heartburn	0.4	0.6	2.0	-0.6	-1.0	0.4	-0.1	0.5	0.5	-1.4
Neck or shoulder pain in last month	0.5	0.7	1.5	-0.5	1.1	-0.9	-0.5	-1.2	-0.7	-0.7
Medication: Blood pressure	0.4	0.6	3.2	-0.6	-0.3	-0.6	-1.8	-0.3	-0.1	-0.6
Angina (self-reported)	0.2	0.3	0.6	-0.6	-0.4	0.8	-0.2	0.4	0.6	0.5
Migraine (self-reported)	2.5	3.1	5.6	-2.2	1.6	-2.2	1.1	-2.4	-1.5	1.0
Medication: Ibuprofen	0.2	0.3	0.5	0.6	-0.3	-0.6	-0.7	-0.3	0.2	-0.6
Medication: Allopurinol	0.9	1.2	2.2	1.1	-0.6	1.2	1.2	1.5	1.0	0.5
Medication: Omeprazole	0.5	0.6	1.8	-0.6	1.3	-0.5	-0.9	-0.3	-0.2	-0.9
Medication: Seretide 50 evohaler	1.0	1.1	1.7	0.2	1.2	1.3	1.3	0.8	1.2	1.0
Mean time to correctly identify matches	0.5	1.0	3.0	-0.3	0.2	1.2	0.8	1.7	1.1	-0.4
Heart disease (mother)	1.4	1.7	3.5	-1.7	0.6	-0.9	1.9	-0.9	-0.3	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.8	-0.0	0.1	-0.3	1.3	-0.5	-0.3	0.8
Whole body fat mass	0.2	0.8	3.2	-0.1	-0.5	-0.2	-1.8	-0.4	-0.6	-1.3
Leg fat mass (right)	0.2	0.6	2.3	0.2	-0.8	0.2	-1.5	0.1	-0.1	-1.0
Arm predicted mass (right)	0.2	0.8	3.4	-0.5	-1.2	-0.0	-1.9	-0.3	-0.5	-0.0
Pulse rate, automated reading	0.2	0.7	2.0	-1.2	0.8	-1.4	-0.6	-0.8	0.0	-0.2
Alcohol intake frequency.	0.8	1.9	3.9	-0.8	-0.9	1.5	0.3	1.4	1.9	-2.0
Comparative height size at age 10	0.0	0.2	0.6	-0.8	-0.6	-0.1	-0.4	-0.3	-0.5	-0.3
Number of full sisters	1.3	1.6	3.2	-1.1	1.8	0.8	1.2	1.1	1.6	1.0
Suffer from ‘nerves’	0.4	0.6	1.5	0.6	-0.7	-0.6	-0.2	-1.1	-1.2	0.5
Overall health rating	0.7	1.4	3.9	1.0	-0.2	2.0	0.7	1.4	1.6	-0.1
Chest pain or discomfort	0.3	0.5	2.6	0.7	-1.6	0.2	0.1	-0.2	0.3	0.1
Had major operations	0.2	0.3	1.0	-1.0	-0.1	-0.1	-0.1	0.4	0.4	0.8
Age at last live birth	0.2	0.2	0.7	0.4	-0.9	0.4	-0.2	0.6	0.2	0.3
Family relationship satisfaction	1.2	1.5	5.7	-2.4	0.4	-1.5	0.6	-1.4	-0.4	0.1
Leg pain on walking	0.5	0.6	1.8	-0.3	-1.3	0.8	-0.6	0.6	0.6	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	3.2	-1.6	0.9	0.5	1.8	0.6	1.6	-0.3
Commuting to job workplace: Car/motor vehicle	1.7	1.9	3.8	0.0	0.7	-1.4	-1.7	-2.0	-1.8	-1.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.8	0.3	-0.8	0.3	0.4	0.7	0.9	-0.6
Medication: Aspirin	0.8	1.0	2.3	1.5	0.9	1.1	-0.1	0.8	0.6	1.4
Supplements: Vitamin C	0.4	0.5	2.5	0.1	0.4	-0.6	1.6	-0.6	0.1	0.5
Knee pain experienced in last month	1.3	2.0	3.2	1.8	-1.7	1.8	0.1	1.5	1.6	0.1
Hypertension (Self-reported)	0.1	0.3	0.6	-0.4	0.3	-0.6	0.2	-0.7	-0.4	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	8.3	-1.1	2.9	-0.8	-1.2	-1.3	-1.0	-0.6
Illnesses of father: Heart disease	0.5	0.7	3.5	-1.1	-0.3	-0.4	-0.4	-0.0	0.0	1.9
Illnesses of siblings: Diabetes	0.9	1.1	1.8	-0.1	1.2	1.2	0.6	1.1	1.3	-1.1
Smoking status: Previous	0.9	1.4	3.4	-1.3	0.9	-1.6	0.7	-1.8	-1.0	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.9	-0.1	0.5	-0.3	-1.4	-0.2	-0.6	0.5
Whole body fat-free mass	0.2	0.9	4.0	-0.1	-1.2	0.3	-2.0	0.0	-0.5	-0.4
Leg fat-free mass (right)	0.3	1.5	6.8	-0.2	-1.3	0.3	-2.6	0.0	-0.7	-1.1
Arm fat percentage (left)	0.2	0.6	2.1	-0.2	0.3	-0.4	-1.4	-0.7	-0.6	-1.1
Average weekly red wine intake	0.2	0.3	0.7	0.3	-0.5	0.3	0.8	0.6	0.4	0.8
Handedness (chirality/laterality): Left-handed	3.2	3.8	7.0	-1.7	0.3	-1.7	-2.6	-1.9	-2.0	-2.5
Mood swings	0.6	1.0	2.1	-1.4	1.4	-0.5	0.2	-1.1	-0.4	1.2
Loneliness, isolation	0.8	1.2	2.1	-1.0	-0.8	-1.4	-0.1	-1.5	-1.2	1.0
Long-standing illness, disability or infirmity	0.1	0.2	0.5	-0.0	-0.4	0.5	0.1	0.6	0.7	0.1
Ever had bowel cancer screening	1.5	1.8	5.1	0.8	-1.4	1.1	1.4	1.0	0.7	2.3
Diabetes diagnosed by doctor	0.5	0.8	2.0	0.2	-0.1	1.4	-0.3	1.0	1.2	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	-0.2	0.3	0.5	0.5	0.4	0.5	0.4
Friendships satisfaction	1.5	1.9	6.8	-2.6	0.5	-0.6	1.8	-0.1	0.2	1.6
Qualifications: nursing, teaching	0.4	0.6	2.3	0.3	-0.4	0.2	-1.5	-0.4	-1.1	0.6
Commuting to job workplace: Walk	1.2	1.3	3.0	0.8	-0.1	0.9	1.7	1.2	1.2	1.3
Eye problems/disorders: Cataract	0.7	0.8	2.1	-1.5	-1.1	0.7	-0.1	0.8	1.0	0.3
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	4.3	-0.1	-0.8	-1.2	0.0	-1.9	-2.1	-1.3
Medication for cholesterol	0.2	0.3	1.0	-0.1	-1.0	-0.1	-0.5	0.2	-0.2	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.4	0.9	-1.2	0.9	1.2	0.2	0.6	-0.6
Back pain experienced in last month	1.5	2.3	3.7	1.5	-0.7	1.9	1.0	1.8	1.8	1.4
Mineral and other dietary supplements	0.2	0.2	0.7	0.1	-0.1	0.0	-0.8	0.5	-0.1	-0.8
Breast cancer (self-reported)	0.6	0.7	1.7	-0.0	0.2	-1.1	-0.5	-0.7	-1.3	1.0
Asthma (self-reported)	0.2	0.5	1.3	-1.2	0.5	-0.1	1.0	-0.7	0.3	0.1
Osteoporosis (self-reported)	2.4	2.9	5.5	2.1	-0.3	2.3	1.2	2.0	2.1	-1.0
Osteoarthritis (self-reported)	0.7	0.9	2.3	0.0	0.7	0.8	1.5	0.9	1.4	0.3
Medication: Aspirin	0.5	0.7	1.8	1.0	1.0	0.7	-0.3	0.6	0.5	1.4
Medication: Gliclazide	0.5	0.6	3.1	-0.4	-0.4	0.1	-0.6	-0.5	-0.5	-1.7
Illnesses of father: None of the above (group 1)	1.4	1.8	3.5	0.9	-0.5	1.9	0.9	1.6	1.8	-1.1
Smoking status: Current	1.7	2.7	6.6	2.0	-1.5	1.1	1.3	1.3	1.2	2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.6	0.9	0.1	1.4	1.9	0.8	1.2	0.6
Whole body water mass	0.1	0.8	3.8	-0.2	-1.2	0.3	-1.9	0.1	-0.4	-0.3
Leg predicted mass (right)	0.3	1.5	7.0	-0.2	-1.2	0.3	-2.6	-0.0	-0.8	-1.1
Arm fat mass (left)	0.2	0.7	3.1	-0.4	-0.4	-0.4	-1.8	-0.6	-0.6	-1.0
Number of self-reported non-cancer illnesses	0.4	0.8	2.5	-0.7	0.8	-0.4	1.6	-0.5	0.1	1.1
Average weekly champagne plus white wine intake	1.2	1.7	3.3	-1.6	-1.8	-1.2	-0.0	-1.4	-1.2	-1.0
Miserableness	0.6	1.1	3.7	0.5	1.5	-0.5	0.8	-0.6	0.1	1.9
Guilty feelings	6.1	9.2	18.9	-4.3	-0.6	-4.2	-0.2	-3.6	-3.0	2.4
Wears glasses or contact lenses	1.1	1.3	6.6	-0.6	-2.6	-0.7	-0.8	-0.3	-0.7	-0.7
Ever taken oral contraceptive pill	0.4	0.5	0.9	-0.9	0.6	-0.8	0.2	-1.0	-0.8	0.0
Hearing aid user	0.6	0.7	2.2	-0.3	-1.5	0.1	1.4	-0.1	0.4	-0.9
Mother’s age at death	1.1	1.4	2.7	-0.6	-0.7	-1.6	-0.9	-1.7	-1.6	-0.6
Financial situation satisfaction	0.5	0.6	1.6	-0.8	-0.1	0.3	-0.8	0.7	1.0	-1.3
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.5	1.6	-0.4	1.2	-0.0	1.1	0.3	-0.2
Commuting to job workplace: Public transport	1.7	2.0	4.7	1.1	-0.8	1.8	1.5	2.2	1.3	0.7
Eye problems/disorders: Glaucoma	0.9	1.1	1.7	-1.2	1.3	-1.0	-1.0	-1.3	-0.6	-0.8
Medication: Blood pressure	0.5	0.9	1.9	-0.8	0.4	-1.1	0.5	-1.4	-0.9	1.0
Pain type(s) experienced in last month: Hip pain	3.1	3.9	8.7	0.8	-0.9	2.9	0.6	2.9	2.9	0.7
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.4	0.1	0.4	0.1	1.6	-0.1	0.2	1.3
High cholesterol (Self-reported)	0.9	1.6	3.1	1.8	-1.7	1.2	-1.1	0.7	0.8	-1.3
Medication: Bendroflumethiazide	0.4	0.6	1.6	-0.0	0.3	-0.8	-0.8	-1.3	-0.8	-0.6
Medication: Paracetamol	0.3	0.5	1.8	-0.2	1.4	-0.7	0.4	-0.6	-0.5	0.2
Medication: Lisinopril	0.6	0.7	1.8	-1.0	-0.0	-1.3	-0.2	-1.2	-1.0	-0.1
Medication: Atorvastatin	0.2	0.2	1.1	-0.1	1.0	-0.3	0.2	-0.1	0.2	0.6
Illnesses of father: High blood pressure	0.6	0.7	1.3	0.6	-0.0	-0.7	-1.1	-1.1	-1.0	0.7
Alcohol drinker status: Never	0.3	0.3	1.2	0.0	-0.8	-0.1	-0.3	0.2	0.5	-1.1
Ever smoked	0.4	0.7	1.5	-0.4	0.8	-1.2	0.4	-1.1	-0.4	1.1
Basal metabolic rate	0.2	0.9	3.9	-0.2	-1.2	0.2	-2.0	-0.1	-0.5	-0.6
Leg fat percentage (left)	0.1	0.5	1.5	0.3	-0.5	0.1	-1.2	-0.2	0.0	-1.2
Arm fat-free mass (left)	0.1	0.7	3.0	-0.5	-1.3	0.1	-1.7	-0.2	-0.2	-0.2
Number of operations (self-reported)	1.2	1.7	3.0	0.5	-0.2	1.6	1.7	1.0	1.5	1.7
Average weekly beer plus cider intake	0.8	1.1	3.7	0.6	1.7	-0.2	-0.8	-0.2	0.3	1.9
Irritability	1.3	2.1	5.3	-1.2	1.1	-1.9	-0.7	-2.3	-1.6	-0.3
Risk taking	0.7	1.0	2.2	1.5	-1.4	1.0	0.3	0.7	1.0	0.7
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.8	0.6	-1.4	0.4	0.5	-0.5	-0.2	0.9
Fractured/broken bones in last 5 years	0.3	0.4	1.0	-0.7	0.4	-0.0	1.0	0.5	0.5	0.7
Age started oral contraceptive pill	1.1	1.4	2.7	-1.3	-1.6	-1.4	0.4	-0.7	-1.1	1.0
Diastolic blood pressure, automated reading	0.6	1.9	7.0	-2.6	1.0	-1.2	0.6	-0.9	-0.2	-1.7
Ever depressed for a whole week	0.2	0.3	0.4	0.2	-0.6	-0.5	0.6	-0.6	-0.6	0.6
Unable to work because of sickness or disability	0.6	0.8	2.6	-0.7	-0.6	-0.3	1.6	-0.6	0.5	1.2
Commuting to job workplace: Cycle	3.0	3.7	10.0	1.0	-1.7	3.2	0.6	2.9	1.7	-0.2
Myopia	1.8	2.6	7.2	1.4	-2.7	1.8	0.7	2.1	0.8	-0.3
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.8	0.8	-0.7	0.9	0.0	0.8	0.5	-0.9
Cholesterol lowering medication	0.9	1.3	2.6	1.2	-0.9	1.6	0.0	1.4	1.6	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.2	-0.8	1.1	-0.2	-0.3	-0.1	0.2	-0.4
Pain experienced in last month	1.1	1.8	3.3	-1.3	-0.8	-1.4	-1.1	-1.1	-1.8	-1.6
Supplements: Calcium	0.1	0.1	0.2	0.5	0.3	0.3	0.2	-0.3	0.2	-0.1
Basal cell carcinoma (self-reported)	0.8	1.0	3.0	-0.5	-1.3	0.6	0.7	0.3	1.0	-1.7
Heart attack/myocardial infarction (self-reported)	0.8	1.1	2.9	1.7	-0.7	1.4	0.0	0.7	0.8	1.0
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.4	-1.2	0.7	-1.0	-0.7	-1.2	-0.5	-0.7
Heart disease (siblings)	2.5	3.1	5.4	1.5	-1.4	2.2	-1.4	2.3	1.3	-1.9
Alcohol drinker status: Previous	1.8	2.1	4.5	-0.0	-1.3	1.9	1.5	1.6	2.1	0.3
Pack years of smoking	0.6	0.9	1.3	1.1	-1.0	1.1	0.8	1.0	0.7	0.8
Impedance of whole body	0.1	0.6	1.8	-0.2	1.2	-0.1	1.4	0.6	0.7	-0.5
Leg fat mass (left)	0.2	0.6	2.6	0.1	-0.7	-0.0	-1.6	-0.1	-0.2	-1.1
Arm predicted mass (left)	0.1	0.5	2.0	-0.6	-1.2	0.3	-1.4	0.1	-0.0	-0.1