Hub : Traits :

Alzheimer’s Disease (including proxy)

164 significantly associated models · 63 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 160452218 161885352 3 2 5.3e-08 8.4e-08 1.0e+00 100 FCER1G NDUFS2
2 1 206975221 208513728 1 1 3.7e-22 9.0e-24 1.0e+00 100 CR1
3 2 127113672 128561279 1 2 1.6e-19 2.5e-36 4.1e-19 50 BIN1
4 2 233227833 234815167 1 1 7.8e-10 2.4e-10 1.0e+00 100 INPP5D
5 6 46757276 48294046 2 1 7.9e-14 1.1e-12 1.4e-01 96 CD2AP
6 7 98879213 100979310 12 1 1.8e-17 2.9e-18 1.0e+00 100 NYAP1
7 7 142447631 143874190 1 1 2.6e-07 2.5e-11 1.1e-07 36 EPHA1-AS1
8 8 26471104 28014376 1 1 6.1e-15 1.4e-24 4.8e-27 -11 PTK2B
9 11 59239839 60768044 2 1 2.6e-13 1.1e-16 7.5e-05 77 MS4A6A
10 11 84971275 86755322 2 2 8.5e-14 4.1e-32 1.7e-14 58 C11orf73 PICALM
11 14 52498111 53940700 1 1 4.4e-08 3.7e-08 1.3e-03 66 STYX
12 16 30154740 31860399 11 1 4.4e-10 3.2e-08 7.1e-01 100 KAT8
13 17 4041725 5725694 5 1 1.3e-08 1.3e-10 1.3e-03 75 AC012146.7
14 17 60858059 62279811 1 1 4.9e-09 2.9e-08 1.0e+00 100 ACE
15 19 44190626 46967227 18 15 6.2e-102 1.7e-208 NaN NaN BCAM BLOC1S3 CEACAM19 CLPTM1 CTB-179K24.3 PVR SFRS16 TOMM40 VASP ZNF180 ZNF229 ZNF285
16 20 54289787 55733453 1 1 7.0e-08 1.0e-07 1.0e+00 100 CASS4

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (in mother) 25.99 16 8 24.2 1.00 2.9e-21 BIN1 BLOC1S3 CEACAM19 CLPTM1 CR1 FCER1G KAT8 NDUFS2 NYAP1 PVR SFRS16 TOMM40 VASP ZNF180 ZNF229 ZNF285
Alzheimer’s Disease (in father) 13.51 8 3 9.1 0.98 3.3e-07 AC012146.7 ACE CEACAM19 NYAP1 PICALM TOMM40 ZNF229 ZNF285
Crohns Disease (2017) 1.20 3 0 0.0 0.00 1.0e+00 BIN1 CASS4 PTK2B
Irritable Bowel Disease (IBD) 1.15 2 0 0.0 0.00 1.0e+00 CASS4 PTK2B
HDL Cholesterol 1.45 2 0 0.0 0.00 1.0e+00 CLPTM1 TOMM40
LDL Cholesterol 8.69 4 4 12.1 0.96 7.7e-04 CEACAM19 TOMM40 ZNF229 ZNF285
Triglycerides 1.76 1 1 3.0 0.00 1.0e+00 KAT8
Blood Eosinophil Count 1.03 6 4 12.1 0.37 4.7e-01 CLPTM1 FCER1G INPP5D KAT8 NDUFS2 TOMM40
Blood Platelet Count 2.08 16 6 18.2 0.00 9.9e-01 AC012146.7 BLOC1S3 C11orf73 CD2AP CEACAM19 CTB-179K24.3 EPHA1-AS1 NDUFS2 PICALM PTK2B PVR SFRS16 STYX TOMM40 VASP ZNF285
Blood Red Count 0.75 6 2 6.1 -0.03 9.5e-01 AC012146.7 BLOC1S3 CTB-179K24.3 KAT8 NDUFS2 NYAP1
Blood White Count 1.56 11 5 15.2 -0.10 7.7e-01 AC012146.7 BCAM BLOC1S3 C11orf73 CR1 FCER1G KAT8 MS4A6A NDUFS2 PTK2B PVR
Heel T-Score 1.21 4 2 6.1 0.93 7.0e-02 AC012146.7 KAT8 MS4A6A VASP
BMI 1.31 5 1 3.0 -0.31 6.1e-01 AC012146.7 KAT8 PTK2B STYX ZNF229
Height 0.42 7 5 15.2 -0.28 5.4e-01 ACE BLOC1S3 CD2AP CLPTM1 KAT8 PICALM ZNF229
Waist Hip Ratio (WHR) 0.65 1 0 0.0 0.00 1.0e+00 NDUFS2
Systolic Blood Pressure 0.94 4 2 6.1 0.85 1.5e-01 ACE BIN1 STYX TOMM40
Allergy or Eczema 1.28 1 1 3.0 0.00 1.0e+00 FCER1G
Cardiovascular Disease 2.57 5 3 9.1 0.26 6.8e-01 ACE KAT8 TOMM40 ZNF229 ZNF285
Respiratory disease 1.08 1 0 0.0 0.00 1.0e+00 FCER1G
Type 2 Diabetes (T2D) 1.48 1 0 0.0 0.00 1.0e+00 ACE
Lung FEV1/FVC ratio 0.85 4 1 3.0 0.99 5.6e-03 KAT8 NYAP1 PTK2B SFRS16
Lung FVC 0.62 3 1 3.0 0.00 1.0e+00 CR1 KAT8 NYAP1
Neuroticism 0.85 1 0 0.0 0.00 1.0e+00 KAT8
Chronotype (morning person) 1.19 1 0 0.0 0.00 1.0e+00 ZNF285
Hand grip strength (left) 1.32 2 0 0.0 0.00 1.0e+00 AC012146.7 KAT8
Number of treatments/medications taken 1.80 2 0 0.0 0.00 1.0e+00 ACE KAT8
Systolic blood pressure, automated reading 0.87 2 0 0.0 0.00 1.0e+00 BIN1 STYX
Impedance of leg (right) 0.35 1 0 0.0 0.00 1.0e+00 KAT8
Leg fat-free mass (left) 0.78 3 1 3.0 0.00 1.0e+00 CLPTM1 KAT8 STYX
Trunk fat percentage 1.19 1 1 3.0 0.00 1.0e+00 KAT8
Hand grip strength (right) 1.22 3 0 0.0 0.00 1.0e+00 AC012146.7 PICALM STYX
Current tobacco smoking 1.46 1 0 0.0 0.00 1.0e+00 VASP
Frequency of unenthusiasm / disinterest in last 2 weeks 1.08 1 0 0.0 0.00 1.0e+00 C11orf73
Age when periods started (menarche) 0.82 1 0 0.0 0.00 1.0e+00 NYAP1
Heel bone mineral density (BMD) T-score, automated (left) 1.03 1 1 3.0 0.00 1.0e+00 MS4A6A
High blood pressure 1.62 2 2 6.1 0.00 1.0e+00 ACE KAT8
Hayfever, allergic rhinitis or eczema 1.19 1 1 3.0 0.00 1.0e+00 FCER1G
Sitting height 0.40 2 0 0.0 0.00 1.0e+00 CD2AP PICALM
Body mass index (BMI) 1.18 1 1 3.0 0.00 1.0e+00 KAT8
Leg predicted mass (left) 0.79 3 1 3.0 0.00 1.0e+00 CLPTM1 KAT8 STYX
Trunk fat mass 1.22 1 1 3.0 0.00 1.0e+00 KAT8
Waist circumference 1.47 2 1 3.0 0.00 1.0e+00 KAT8 PTK2B
Number of incorrect matches in round 0.95 1 0 0.0 0.00 1.0e+00 KAT8
Nervous feelings 1.13 1 1 3.0 0.00 1.0e+00 KAT8
Heel bone mineral density (BMD) T-score, automated (right) 0.90 1 1 3.0 0.00 1.0e+00 MS4A6A
Financial difficulties in last 2 years 1.34 1 0 0.0 0.00 1.0e+00 KAT8
Allergy 1.13 1 1 3.0 0.00 1.0e+00 FCER1G
Diabetes (self-reported) 1.76 1 0 0.0 0.00 1.0e+00 ACE
Hayfever/allergic rhinitis (self-reported) 0.98 1 0 0.0 0.00 1.0e+00 FCER1G
Medication: Simvastatin 3.52 3 1 3.0 0.00 1.0e+00 CEACAM19 TOMM40 ZNF229
Illnesses of siblings 1.64 1 0 0.0 0.00 1.0e+00 KAT8
Weight 1.17 4 1 3.0 0.04 9.6e-01 AC012146.7 CLPTM1 KAT8 STYX
Arm fat percentage (right) 1.30 2 1 3.0 0.00 1.0e+00 ACE KAT8
Trunk fat-free mass 0.65 2 1 3.0 0.00 1.0e+00 CLPTM1 KAT8
Hip circumference 1.27 3 1 3.0 0.00 1.0e+00 CLPTM1 KAT8 STYX
Worrier / anxious feelings 0.92 1 0 0.0 0.00 1.0e+00 KAT8
Forced expiratory volume in 1-second (FEV1) 0.76 1 0 0.0 0.00 1.0e+00 KAT8
Pulse rate 1.04 1 0 0.0 0.00 1.0e+00 NYAP1
Mouth/teeth dental problems: Dentures 1.41 2 0 0.0 0.00 1.0e+00 FCER1G VASP
Asthma 1.14 1 0 0.0 0.00 1.0e+00 FCER1G
Medication: Cholesterol lowering 3.51 2 2 6.1 0.00 1.0e+00 TOMM40 ZNF229
Forced expiratory volume in 1-second (FEV1), Best measure 0.77 1 0 0.0 0.00 1.0e+00 KAT8
Arm fat mass (right) 1.32 1 1 3.0 0.00 1.0e+00 KAT8
Trunk predicted mass 0.64 2 1 3.0 0.00 1.0e+00 CLPTM1 KAT8
Standing height 0.47 3 1 3.0 0.00 1.0e+00 CD2AP CLPTM1 PICALM
Tense / 'highly strung' 1.26 1 0 0.0 0.00 1.0e+00 KAT8
Peak expiratory flow (PEF) 1.09 1 0 0.0 0.00 1.0e+00 PTK2B
Medication for cholesterol, blood pressure or diabetes 2.53 3 1 3.0 0.00 1.0e+00 ACE NYAP1 TOMM40
High blood pressure (siblings) 1.86 1 0 0.0 0.00 1.0e+00 KAT8
Body fat percentage 1.26 3 1 3.0 0.00 1.0e+00 ACE KAT8 PTK2B
Leg fat percentage (right) 1.22 2 1 3.0 0.00 1.0e+00 KAT8 PTK2B
Arm fat-free mass (right) 0.71 2 1 3.0 0.00 1.0e+00 CLPTM1 KAT8
Comparative body size at age 10 0.79 1 0 0.0 0.00 1.0e+00 KAT8
Wheeze or whistling in the chest in last year 0.90 1 0 0.0 0.00 1.0e+00 KAT8
Eye problems/disorders: None of the above 1.06 1 0 0.0 0.00 1.0e+00 CASS4
Medication for pain relief, constipation, heartburn 1.30 1 0 0.0 0.00 1.0e+00 ACE
Medication: Blood pressure 1.65 2 1 3.0 0.00 1.0e+00 ACE NYAP1
Whole body fat mass 1.25 1 1 3.0 0.00 1.0e+00 KAT8
Leg fat mass (right) 1.33 2 1 3.0 0.00 1.0e+00 AC012146.7 KAT8
Arm predicted mass (right) 0.71 2 1 3.0 0.00 1.0e+00 CLPTM1 KAT8
Pulse rate, automated reading 0.97 2 1 3.0 0.00 1.0e+00 KAT8 NYAP1
Alcohol intake frequency. 0.95 1 0 0.0 0.00 1.0e+00 KAT8
Comparative height size at age 10 0.52 1 0 0.0 0.00 1.0e+00 CD2AP
Suffer from 'nerves' 1.13 1 0 0.0 0.00 1.0e+00 KAT8
Overall health rating 1.27 1 1 3.0 0.00 1.0e+00 KAT8
Had major operations 1.20 1 0 0.0 0.00 1.0e+00 PTK2B
Knee pain experienced in last month 1.15 1 0 0.0 0.00 1.0e+00 KAT8
Hypertension (Self-reported) 1.66 2 2 6.1 0.00 1.0e+00 ACE KAT8
Whole body fat-free mass 0.71 2 1 3.0 0.00 1.0e+00 CLPTM1 KAT8
Leg fat-free mass (right) 0.77 3 1 3.0 0.00 1.0e+00 CLPTM1 KAT8 STYX
Arm fat percentage (left) 1.24 2 1 3.0 0.00 1.0e+00 ACE KAT8
Diabetes diagnosed by doctor 1.88 1 0 0.0 0.00 1.0e+00 ACE
Mouth/teeth dental problems: Mouth ulcers 1.33 1 1 3.0 0.00 1.0e+00 NDUFS2
Medication for cholesterol 1.64 2 0 0.0 0.00 1.0e+00 ACE KAT8
Asthma (self-reported) 1.17 1 0 0.0 0.00 1.0e+00 FCER1G
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.23 1 1 3.0 0.00 1.0e+00 KAT8
Whole body water mass 0.70 2 1 3.0 0.00 1.0e+00 CLPTM1 KAT8
Leg predicted mass (right) 0.78 3 1 3.0 0.00 1.0e+00 CLPTM1 KAT8 STYX
Arm fat mass (left) 1.29 1 1 3.0 0.00 1.0e+00 KAT8
Medication: Blood pressure 1.35 2 1 3.0 0.00 1.0e+00 ACE KAT8
High cholesterol (Self-reported) 5.36 5 3 9.1 -0.93 7.4e-04 CEACAM19 KAT8 TOMM40 ZNF229 ZNF285
Medication: Bendroflumethiazide 1.19 1 0 0.0 0.00 1.0e+00 KAT8
Medication: Atorvastatin 3.09 3 1 3.0 0.00 1.0e+00 TOMM40 ZNF229 ZNF285
Illnesses of father: High blood pressure 1.35 1 0 0.0 0.00 1.0e+00 ACE
Basal metabolic rate 0.82 3 1 3.0 0.00 1.0e+00 AC012146.7 CLPTM1 KAT8
Leg fat percentage (left) 1.24 2 1 3.0 0.00 1.0e+00 KAT8 PTK2B
Arm fat-free mass (left) 0.79 3 1 3.0 0.00 1.0e+00 AC012146.7 CLPTM1 KAT8
Diastolic blood pressure, automated reading 0.98 2 1 3.0 0.00 1.0e+00 ACE KAT8
Vascular/heart problems diagnosed by doctor 1.71 3 2 6.1 0.00 1.0e+00 ACE KAT8 PTK2B
Cholesterol lowering medication 3.36 4 1 3.0 -0.94 6.4e-02 KAT8 TOMM40 ZNF229 ZNF285
Pain experienced in last month 0.75 1 0 0.0 0.00 1.0e+00 KAT8
Leg fat mass (left) 1.33 2 1 3.0 0.00 1.0e+00 AC012146.7 KAT8
Arm predicted mass (left) 0.81 3 1 3.0 0.00 1.0e+00 AC012146.7 CLPTM1 KAT8

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 6 0.1718 1.47
GTEx Adipose Visceral Omentum 2 0.0981 1.59
GTEx Adrenal Gland 2 0.1372 1.37
GTEx Artery Aorta 1 0.0336 1.41
GTEx Artery Coronary 3 0.2534 1.41
GTEx Artery Tibial 5 0.1329 1.45
GTEx Brain Caudate basal ganglia 1 0.1085 1.33
GTEx Brain Cerebellar Hemisphere 1 0.0671 1.37
GTEx Brain Cerebellum 3 0.1512 1.41
GTEx Brain Cortex 1 0.0965 1.23
GTEx Brain Frontal Cortex BA9 1 0.1080 1.31
GTEx Brain Hippocampus 0 0.0000 1.26
GTEx Brain Hypothalamus 0 0.0000 1.18
GTEx Brain Nucleus accumbens basal ganglia 4 0.4619 1.43
GTEx Brain Putamen basal ganglia 0 0.0000 1.30
GTEx Breast Mammary Tissue 1 0.0506 1.34
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.28
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.29
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.34
GTEx Cells Transformed fibroblasts 8 0.1905 1.43
GTEx Colon Sigmoid 1 0.0684 1.29
GTEx Colon Transverse 4 0.1935 1.42
GTEx Esophagus Gastroesophageal Junction 1 0.0691 1.38
GTEx Esophagus Mucosa 5 0.1505 1.43
GTEx Esophagus Muscularis 6 0.1856 1.46
GTEx Heart Atrial Appendage 1 0.0633 1.41
GTEx Heart Left Ventricle 1 0.0652 1.37
GTEx Liver 5 0.6964 1.64
GTEx Lung 4 0.1391 1.43
GTEx Muscle Skeletal 2 0.0691 1.39
GTEx Nerve Tibial 8 0.1849 1.42
GTEx Ovary 1 0.1099 1.45
GTEx Pancreas 2 0.1225 1.29
GTEx Pituitary 4 0.3587 1.46
GTEx Prostate 1 0.1198 1.31
GTEx Skin Not Sun Exposed Suprapubic 6 0.2437 1.59
GTEx Skin Sun Exposed Lower leg 5 0.1374 1.41
GTEx Small Intestine Terminal Ileum 0 0.0000 1.29
GTEx Spleen 1 0.0708 1.33
GTEx Stomach 4 0.2747 1.47
GTEx Testis 2 0.0634 1.43
GTEx Thyroid 8 0.2000 1.48
GTEx Uterus 0 0.0000 1.35
GTEx Vagina 1 0.1572 1.38
GTEx Whole Blood 3 0.1505 1.49
METSIM Adipose 4 0.0868 1.36
NTR Blood 8 0.3328 1.55
ROSMAP Brain Pre-frontal Cortex 6 0.1366 1.43
YFS Blood 8 0.1732 1.47
CommonMind Brain Pre-frontal Cortex 7 0.1302 1.44
TCGA Breast Tumor 0 0.0000 1.31
TCGA Breast Normal 8 0.1901 1.40
TCGA Ovarian Tumor 3 0.1027 1.34
TCGA Prostate Tumor 4 0.1156 1.37