Hub : Traits :

Frequency of tiredness / lethargy in last 2 weeks

162 significantly associated models · 32 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 207107801 208531683 1 1 3.9e-07 2.2e-07 0.067 88 CPO
2 3 48012797 50267837 19 1 7.2e-12 3.4e-11 1.000 100 USP4
3 3 166760899 168242895 1 1 1.4e-08 1.4e-05 0.262 93 SERPINI1
4 9 95502571 96898436 1 1 6.8e-09 1.4e-08 1.000 100 RP11-165J3.6
5 11 46033104 47419663 1 1 2.3e-09 3.8e-07 0.072 88 ZNF408
6 11 56742853 58178587 2 1 2.2e-07 4.8e-07 0.452 98 ZDHHC5
7 12 108763672 110704487 4 1 6.5e-11 2.3e-10 0.053 91 MMAB
8 17 1594359 3287175 3 2 7.1e-09 2.4e-09 0.091 92 PAFAH1B1 RP1-59D14.1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Major Depression (MDD) 7.50 3 1 3.0 0.00 1.0e+00 CPO USP4 ZDHHC5
Reaction Time 2.05 1 0 0.0 0.00 1.0e+00 ZNF408
Verbal and Numeric Reasoning (VNR) 1.49 1 0 0.0 0.00 1.0e+00 ZDHHC5
HDL Cholesterol 4.26 1 1 3.0 0.00 1.0e+00 MMAB
Neuroticism 8.17 4 0 0.0 -1.00 3.8e-03 CPO PAFAH1B1 RP1-59D14.1 ZNF408
Schizophrenia 2.74 1 0 0.0 0.00 1.0e+00 ZDHHC5
Triglycerides 1.85 1 0 0.0 0.00 1.0e+00 ZNF408
Blood Eosinophil Count 1.45 2 1 3.0 0.00 1.0e+00 USP4 ZDHHC5
Blood Platelet Count 1.66 4 2 6.1 -0.97 2.6e-02 CPO PAFAH1B1 RP1-59D14.1 ZDHHC5
Blood Red Count 1.00 3 0 0.0 0.00 1.0e+00 RP1-59D14.1 USP4 ZDHHC5
Blood White Count 0.62 1 0 0.0 0.00 1.0e+00 SERPINI1
Heel T-Score 5.42 4 3 9.1 0.55 4.5e-01 RP1-59D14.1 USP4 ZDHHC5 ZNF408
Height 0.83 3 2 6.1 0.00 1.0e+00 PAFAH1B1 RP11-165J3.6 ZDHHC5
Waist Hip Ratio (WHR) 0.80 1 1 3.0 0.00 1.0e+00 USP4
Systolic Blood Pressure 3.97 3 3 9.1 0.00 1.0e+00 PAFAH1B1 ZDHHC5 ZNF408
Smoking Status 2.96 1 1 3.0 0.00 1.0e+00 USP4
Cardiovascular Disease 1.65 2 1 3.0 0.00 1.0e+00 SERPINI1 ZNF408
Lung FEV1/FVC ratio 1.28 1 1 3.0 0.00 1.0e+00 ZDHHC5
Neuroticism 11.43 7 5 15.2 -0.98 1.0e-04 MMAB PAFAH1B1 RP11-165J3.6 RP1-59D14.1 USP4 ZDHHC5 ZNF408
Chronotype (morning person) 2.30 2 0 0.0 0.00 1.0e+00 USP4 ZDHHC5
Hand grip strength (left) 1.40 1 0 0.0 0.00 1.0e+00 ZDHHC5
Sensitivity / hurt feelings 6.11 3 1 3.0 0.00 1.0e+00 MMAB RP11-165J3.6 ZDHHC5
Frequency of depressed mood in last 2 weeks 9.44 5 0 0.0 1.00 7.2e-05 CPO PAFAH1B1 RP11-165J3.6 ZDHHC5 ZNF408
Hearing difficulty/problems: Yes 4.81 2 0 0.0 0.00 1.0e+00 CPO MMAB
Systolic blood pressure, automated reading 3.19 3 0 0.0 0.00 1.0e+00 PAFAH1B1 ZDHHC5 ZNF408
Angina 2.91 1 0 0.0 0.00 1.0e+00 CPO
Pack years adult smoking proportion 4.28 2 0 0.0 0.00 1.0e+00 RP1-59D14.1 USP4
Impedance of leg (right) 1.86 2 1 3.0 0.00 1.0e+00 CPO RP1-59D14.1
Leg fat-free mass (left) 1.24 2 0 0.0 0.00 1.0e+00 CPO ZNF408
Trunk fat percentage 1.66 2 0 0.0 0.00 1.0e+00 RP1-59D14.1 ZDHHC5
Townsend deprivation index at recruitment 4.41 1 0 0.0 0.00 1.0e+00 ZDHHC5
Current tobacco smoking 3.77 1 0 0.0 0.00 1.0e+00 CPO
Fed-up feelings 8.47 4 1 3.0 0.96 3.8e-02 PAFAH1B1 USP4 ZDHHC5 ZNF408
Frequency of unenthusiasm / disinterest in last 2 weeks 6.64 2 0 0.0 0.00 1.0e+00 RP11-165J3.6 ZDHHC5
Relative age voice broke 2.96 1 0 0.0 0.00 1.0e+00 USP4
Age when periods started (menarche) 3.20 1 1 3.0 0.00 1.0e+00 USP4
Heel bone mineral density (BMD) T-score, automated (left) 4.06 2 1 3.0 0.00 1.0e+00 USP4 ZNF408
High blood pressure 2.85 2 1 3.0 0.00 1.0e+00 SERPINI1 ZNF408
Stomach or abdominal pain in last month 3.35 1 0 0.0 0.00 1.0e+00 RP11-165J3.6
Supplements: Glucosamine 2.87 1 0 0.0 0.00 1.0e+00 ZNF408
Sitting height 1.32 3 1 3.0 0.00 1.0e+00 RP11-165J3.6 ZDHHC5 ZNF408
Impedance of leg (left) 1.91 3 1 3.0 0.00 1.0e+00 CPO RP1-59D14.1 USP4
Leg predicted mass (left) 1.23 2 0 0.0 0.00 1.0e+00 CPO ZNF408
Alcohol usually taken with meals 5.46 2 2 6.1 0.00 1.0e+00 RP1-59D14.1 ZDHHC5
Nervous feelings 4.03 1 0 0.0 0.00 1.0e+00 ZNF408
Frequency of tenseness / restlessness in last 2 weeks 8.36 5 1 3.0 1.00 7.0e-06 CPO MMAB RP11-165J3.6 USP4 ZNF408
Hearing difficulty/problems with background noise 5.24 3 0 0.0 0.00 1.0e+00 CPO PAFAH1B1 ZNF408
Forced vital capacity (FVC) 1.54 1 0 0.0 0.00 1.0e+00 ZNF408
Heel bone mineral density (BMD) T-score, automated (right) 4.62 2 2 6.1 0.00 1.0e+00 USP4 ZNF408
Ever unenthusiastic/disinterested for a whole week 3.70 1 0 0.0 0.00 1.0e+00 USP4
Qualifications: None of the above 3.16 1 0 0.0 0.00 1.0e+00 ZDHHC5
Mouth/teeth dental problems 2.88 1 0 0.0 0.00 1.0e+00 MMAB
Allergy 1.45 1 0 0.0 0.00 1.0e+00 MMAB
Neuroticism score 10.53 7 5 15.2 0.98 1.2e-04 MMAB PAFAH1B1 RP11-165J3.6 RP1-59D14.1 USP4 ZDHHC5 ZNF408
Weight 0.65 1 0 0.0 0.00 1.0e+00 CPO
Impedance of arm (right) 1.93 2 1 3.0 0.00 1.0e+00 USP4 ZDHHC5
Arm fat percentage (right) 1.69 1 0 0.0 0.00 1.0e+00 ZDHHC5
Trunk fat-free mass 1.93 3 0 0.0 0.00 1.0e+00 CPO ZDHHC5 ZNF408
Worrier / anxious feelings 5.66 3 1 3.0 0.00 1.0e+00 MMAB RP11-165J3.6 ZDHHC5
Forced expiratory volume in 1-second (FEV1) 2.10 1 0 0.0 0.00 1.0e+00 ZDHHC5
Pulse rate 2.33 1 0 0.0 0.00 1.0e+00 USP4
Forced expiratory volume in 1-second (FEV1), Best measure 2.30 2 0 0.0 0.00 1.0e+00 ZDHHC5 ZNF408
Impedance of arm (left) 2.49 2 1 3.0 0.00 1.0e+00 USP4 ZDHHC5
Arm fat mass (right) 1.07 1 0 0.0 0.00 1.0e+00 SERPINI1
Trunk predicted mass 1.90 3 0 0.0 0.00 1.0e+00 CPO ZDHHC5 ZNF408
Standing height 1.04 4 1 3.0 -0.46 5.4e-01 PAFAH1B1 RP11-165J3.6 ZDHHC5 ZNF408
Tense / 'highly strung' 4.37 3 1 3.0 0.00 1.0e+00 RP11-165J3.6 USP4 ZDHHC5
Seen doctor (GP) for nerves, anxiety, tension or depression 5.41 3 0 0.0 0.00 1.0e+00 RP11-165J3.6 USP4 ZNF408
Birth weight of first child 1.78 1 0 0.0 0.00 1.0e+00 PAFAH1B1
Peak expiratory flow (PEF) 1.69 1 0 0.0 0.00 1.0e+00 ZDHHC5
Medication: Paracetamol 4.86 4 0 0.0 1.00 3.5e-03 CPO MMAB RP11-165J3.6 USP4
Headache pain in last month 2.57 1 0 0.0 0.00 1.0e+00 ZDHHC5
Medication: Amlodipine 1.92 1 0 0.0 0.00 1.0e+00 ZNF408
Forced vital capacity (FVC), Best measure 1.78 1 0 0.0 0.00 1.0e+00 ZNF408
Body fat percentage 1.78 2 0 0.0 0.00 1.0e+00 RP1-59D14.1 ZDHHC5
Leg fat percentage (right) 2.07 1 0 0.0 0.00 1.0e+00 RP1-59D14.1
Arm fat-free mass (right) 1.42 1 0 0.0 0.00 1.0e+00 CPO
Comparative body size at age 10 1.96 1 1 3.0 0.00 1.0e+00 RP11-165J3.6
Number of full brothers 2.80 1 0 0.0 0.00 1.0e+00 USP4
Worry too long after embarrassment 7.38 4 2 6.1 0.98 1.9e-02 MMAB PAFAH1B1 RP1-59D14.1 ZDHHC5
Wheeze or whistling in the chest in last year 2.57 1 0 0.0 0.00 1.0e+00 RP11-165J3.6
Age at first live birth 1.88 1 0 0.0 0.00 1.0e+00 USP4
Qualifications: College or University degree 1.80 2 0 0.0 0.00 1.0e+00 RP1-59D14.1 ZDHHC5
Medication for pain relief, constipation, heartburn 4.25 2 1 3.0 0.00 1.0e+00 CPO RP11-165J3.6
Neck or shoulder pain in last month 4.20 1 0 0.0 0.00 1.0e+00 USP4
Medication: Blood pressure 1.65 1 0 0.0 0.00 1.0e+00 ZNF408
Mean time to correctly identify matches 2.68 1 0 0.0 0.00 1.0e+00 ZNF408
Arm predicted mass (right) 1.33 1 0 0.0 0.00 1.0e+00 CPO
Pulse rate, automated reading 3.77 3 2 6.1 0.00 1.0e+00 RP1-59D14.1 USP4 ZDHHC5
Alcohol intake frequency. 2.00 1 0 0.0 0.00 1.0e+00 ZDHHC5
Comparative height size at age 10 1.13 1 0 0.0 0.00 1.0e+00 PAFAH1B1
Suffer from 'nerves' 3.41 1 0 0.0 0.00 1.0e+00 ZNF408
Overall health rating 8.54 8 3 9.1 0.98 2.5e-05 CPO PAFAH1B1 RP11-165J3.6 RP1-59D14.1 SERPINI1 USP4 ZDHHC5 ZNF408
Chest pain or discomfort 4.74 2 0 0.0 0.00 1.0e+00 CPO USP4
Medication: Aspirin 2.06 1 0 0.0 0.00 1.0e+00 CPO
Hypertension (Self-reported) 2.66 1 1 3.0 0.00 1.0e+00 ZNF408
Whole body fat-free mass 1.61 2 0 0.0 0.00 1.0e+00 CPO ZNF408
Leg fat-free mass (right) 1.35 2 0 0.0 0.00 1.0e+00 CPO ZNF408
Arm fat percentage (left) 1.55 1 0 0.0 0.00 1.0e+00 ZDHHC5
Average weekly red wine intake 4.75 2 1 3.0 0.00 1.0e+00 RP1-59D14.1 ZDHHC5
Mood swings 6.92 4 0 0.0 0.99 8.5e-03 MMAB RP11-165J3.6 USP4 ZNF408
Loneliness, isolation 6.22 3 0 0.0 0.00 1.0e+00 RP11-165J3.6 ZDHHC5 ZNF408
Qualifications: nursing, teaching 1.67 1 0 0.0 0.00 1.0e+00 ZDHHC5
Osteoarthritis (self-reported) 2.02 1 0 0.0 0.00 1.0e+00 RP11-165J3.6
Medication: Aspirin 1.61 1 0 0.0 0.00 1.0e+00 CPO
Whole body water mass 1.56 2 0 0.0 0.00 1.0e+00 CPO ZNF408
Leg predicted mass (right) 1.36 2 0 0.0 0.00 1.0e+00 CPO ZNF408
Number of self-reported non-cancer illnesses 3.77 2 0 0.0 0.00 1.0e+00 SERPINI1 ZNF408
Miserableness 10.27 5 4 12.1 0.99 8.6e-04 MMAB PAFAH1B1 RP11-165J3.6 USP4 ZNF408
Guilty feelings 5.74 2 1 3.0 0.00 1.0e+00 PAFAH1B1 ZDHHC5
Medication: Blood pressure 1.67 1 0 0.0 0.00 1.0e+00 ZNF408
Medication: Paracetamol 4.26 2 0 0.0 0.00 1.0e+00 CPO USP4
Medication: Lisinopril 3.88 2 0 0.0 0.00 1.0e+00 SERPINI1 ZNF408
Ever smoked 2.73 1 0 0.0 0.00 1.0e+00 USP4
Basal metabolic rate 1.26 2 0 0.0 0.00 1.0e+00 CPO ZNF408
Leg fat percentage (left) 2.01 2 0 0.0 0.00 1.0e+00 PAFAH1B1 RP1-59D14.1
Arm fat-free mass (left) 1.48 1 0 0.0 0.00 1.0e+00 CPO
Irritability 5.78 3 1 3.0 0.00 1.0e+00 MMAB PAFAH1B1 USP4
Ever had prostate specific antigen (PSA) test 3.77 1 0 0.0 0.00 1.0e+00 PAFAH1B1
Diastolic blood pressure, automated reading 1.90 2 0 0.0 0.00 1.0e+00 PAFAH1B1 ZNF408
Ever depressed for a whole week 4.15 1 0 0.0 0.00 1.0e+00 USP4
Unable to work because of sickness or disability 3.42 1 0 0.0 0.00 1.0e+00 ZDHHC5
Commuting to job workplace: Cycle 3.13 1 0 0.0 0.00 1.0e+00 RP1-59D14.1
Vascular/heart problems diagnosed by doctor 3.01 2 1 3.0 0.00 1.0e+00 SERPINI1 ZNF408
Pain experienced in last month 6.99 3 1 3.0 0.00 1.0e+00 CPO MMAB RP11-165J3.6
Pack years of smoking 4.05 2 0 0.0 0.00 1.0e+00 RP1-59D14.1 USP4
Impedance of whole body 2.34 3 1 3.0 0.00 1.0e+00 CPO RP1-59D14.1 USP4
Arm predicted mass (left) 1.33 1 0 0.0 0.00 1.0e+00 CPO

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 6 0.1719 1.67
GTEx Adipose Visceral Omentum 4 0.1965 1.65
GTEx Adrenal Gland 0 0.0000 1.62
GTEx Artery Aorta 4 0.1344 1.70
GTEx Artery Coronary 3 0.2536 1.69
GTEx Artery Tibial 4 0.1064 1.64
GTEx Brain Caudate basal ganglia 3 0.3261 1.59
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.60
GTEx Brain Cerebellum 2 0.1009 1.62
GTEx Brain Cortex 2 0.1932 1.66
GTEx Brain Frontal Cortex BA9 4 0.4329 1.65
GTEx Brain Hippocampus 1 0.1908 1.59
GTEx Brain Hypothalamus 1 0.1695 1.58
GTEx Brain Nucleus accumbens basal ganglia 1 0.1156 1.52
GTEx Brain Putamen basal ganglia 2 0.3205 1.62
GTEx Breast Mammary Tissue 4 0.2026 1.73
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.65
GTEx Breast Mammary Tissue (Female) 2 0.1217 1.59
GTEx Cells EBV-transformed lymphocytes 3 0.2108 1.78
GTEx Cells Transformed fibroblasts 6 0.1429 1.71
GTEx Colon Sigmoid 4 0.2736 1.67
GTEx Colon Transverse 6 0.2907 1.73
GTEx Esophagus Gastroesophageal Junction 3 0.2076 1.73
GTEx Esophagus Mucosa 6 0.1807 1.64
GTEx Esophagus Muscularis 3 0.0928 1.74
GTEx Heart Atrial Appendage 2 0.1267 1.72
GTEx Heart Left Ventricle 2 0.1307 1.80
GTEx Liver 1 0.1395 1.79
GTEx Lung 7 0.2436 1.71
GTEx Muscle Skeletal 3 0.1038 1.69
GTEx Nerve Tibial 7 0.1620 1.69
GTEx Ovary 3 0.3304 1.81
GTEx Pancreas 1 0.0613 1.66
GTEx Pituitary 3 0.2691 1.62
GTEx Prostate 1 0.1198 1.65
GTEx Skin Not Sun Exposed Suprapubic 6 0.2440 1.79
GTEx Skin Sun Exposed Lower leg 9 0.2473 1.69
GTEx Small Intestine Terminal Ileum 1 0.2169 1.79
GTEx Spleen 1 0.0709 1.65
GTEx Stomach 2 0.1376 1.63
GTEx Testis 2 0.0634 1.63
GTEx Thyroid 11 0.2751 1.71
GTEx Uterus 2 0.3527 1.71
GTEx Vagina 1 0.1575 1.70
GTEx Whole Blood 2 0.1004 1.70
METSIM Adipose 2 0.0434 1.58
NTR Blood 1 0.0416 1.62
ROSMAP Brain Pre-frontal Cortex 6 0.1366 1.63
YFS Blood 4 0.0866 1.57
CommonMind Brain Pre-frontal Cortex 3 0.0558 1.63
TCGA Breast Tumor 1 0.1304 1.70
TCGA Breast Normal 2 0.0475 1.47
TCGA Ovarian Tumor 0 0.0000 1.51
TCGA Prostate Tumor 1 0.0289 1.57