Hub : Traits :

Qualifications: O levels/GCSEs or equivalent

82 significantly associated models · 20 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 43476957 45153116 3 1 7.8e-08 1.3e-09 0.00093 70 ST3GAL3
2 1 204888754 205921859 1 1 1.6e-08 9.0e-07 0.03610 82 ELK4
3 2 43899918 45698128 1 1 1.1e-09 4.3e-09 1.00000 100 CAMKMT
4 2 98921826 100615241 2 1 1.4e-07 4.5e-07 0.06370 86 TSGA10
5 3 48702606 50085153 1 1 5.9e-08 6.9e-07 0.11400 90 GPX1
6 12 122713991 124591385 10 1 3.6e-11 7.1e-11 0.31000 98 C12orf65
7 15 39959900 41353079 1 1 1.6e-07 3.9e-05 0.83500 100 DISP2
8 16 4049365 5441125 1 1 9.5e-08 1.5e-06 0.52700 98 NUDT16L1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 2.62 1 1 3.0 0.00 1.0e+00 GPX1
Irritable Bowel Disease (IBD) 3.59 1 1 3.0 0.00 1.0e+00 GPX1
Ulcerative Colitis (UC) 3.06 1 1 3.0 0.00 1.0e+00 GPX1
Major Depression (MDD) 3.75 1 0 0.0 0.00 1.0e+00 GPX1
Verbal and Numeric Reasoning (VNR) 6.21 5 2 6.1 -0.96 1.1e-02 C12orf65 CAMKMT DISP2 GPX1 ST3GAL3
Prostate Cancer 3.32 1 0 0.0 0.00 1.0e+00 GPX1
Age at First Birth 4.18 1 1 3.0 0.00 1.0e+00 GPX1
Neuroticism 2.21 1 0 0.0 0.00 1.0e+00 GPX1
Schizophrenia 2.46 1 1 3.0 0.00 1.0e+00 C12orf65
Type 2 Diabetes (T2D) 1.50 1 0 0.0 0.00 1.0e+00 C12orf65
Ulcerative Colitis 2.72 1 1 3.0 0.00 1.0e+00 GPX1
Blood Eosinophil Count 1.78 3 1 3.0 0.00 1.0e+00 C12orf65 GPX1 TSGA10
Blood Platelet Count 5.63 3 3 9.1 0.00 1.0e+00 C12orf65 ELK4 NUDT16L1
Blood Red Count 1.18 2 1 3.0 0.00 1.0e+00 CAMKMT ELK4
Blood White Count 1.03 2 0 0.0 0.00 1.0e+00 GPX1 NUDT16L1
Heel T-Score 1.81 1 1 3.0 0.00 1.0e+00 C12orf65
BMI 2.80 3 2 6.1 0.00 1.0e+00 CAMKMT GPX1 ST3GAL3
Height 3.77 7 6 18.2 -0.78 3.9e-02 C12orf65 CAMKMT DISP2 ELK4 GPX1 NUDT16L1 TSGA10
Waist Hip Ratio (WHR) 4.48 3 3 9.1 0.00 1.0e+00 C12orf65 DISP2 GPX1
Systolic Blood Pressure 2.60 2 1 3.0 0.00 1.0e+00 GPX1 NUDT16L1
Smoking Status 3.32 2 1 3.0 0.00 1.0e+00 GPX1 TSGA10
Allergy or Eczema 1.78 1 0 0.0 0.00 1.0e+00 C12orf65
Cardiovascular Disease 1.85 1 0 0.0 0.00 1.0e+00 NUDT16L1
Type 2 Diabetes (T2D) 2.07 1 0 0.0 0.00 1.0e+00 CAMKMT
Lung FEV1/FVC ratio 1.86 2 1 3.0 0.00 1.0e+00 ELK4 TSGA10
Lung FVC 2.68 3 2 6.1 0.00 1.0e+00 C12orf65 DISP2 GPX1
Neuroticism 2.14 1 1 3.0 0.00 1.0e+00 GPX1
Chronotype (morning person) 2.10 2 0 0.0 0.00 1.0e+00 CAMKMT GPX1
Hair Pigment 0.46 2 2 6.1 0.00 1.0e+00 C12orf65 ELK4
Tanning 0.37 1 0 0.0 0.00 1.0e+00 ELK4
Hand grip strength (left) 3.12 2 1 3.0 0.00 1.0e+00 ELK4 NUDT16L1
Number of treatments/medications taken 5.43 3 0 0.0 0.00 1.0e+00 ELK4 GPX1 NUDT16L1
Systolic blood pressure, automated reading 3.27 2 2 6.1 0.00 1.0e+00 GPX1 NUDT16L1
Medication: Co-codamol 3.07 1 0 0.0 0.00 1.0e+00 GPX1
Pack years adult smoking proportion 3.24 1 0 0.0 0.00 1.0e+00 GPX1
Impedance of leg (right) 1.04 1 1 3.0 0.00 1.0e+00 GPX1
Leg fat-free mass (left) 2.31 3 1 3.0 0.00 1.0e+00 C12orf65 GPX1 NUDT16L1
Trunk fat percentage 1.52 3 0 0.0 0.00 1.0e+00 CAMKMT GPX1 NUDT16L1
Hand grip strength (right) 2.80 2 1 3.0 0.00 1.0e+00 ELK4 TSGA10
Current tobacco smoking 3.13 1 0 0.0 0.00 1.0e+00 GPX1
Fed-up feelings 4.89 1 1 3.0 0.00 1.0e+00 GPX1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.32 1 0 0.0 0.00 1.0e+00 GPX1
Taking other prescription medications 3.75 1 0 0.0 0.00 1.0e+00 GPX1
Age when periods started (menarche) 2.76 1 1 3.0 0.00 1.0e+00 GPX1
Qualifications: CSEs or equivalent 3.93 2 0 0.0 0.00 1.0e+00 GPX1 ST3GAL3
High blood pressure 2.64 2 1 3.0 0.00 1.0e+00 ELK4 NUDT16L1
Hayfever, allergic rhinitis or eczema 1.80 1 0 0.0 0.00 1.0e+00 C12orf65
Sitting height 4.79 5 1 3.0 0.92 2.7e-02 C12orf65 CAMKMT ELK4 NUDT16L1 TSGA10
Body mass index (BMI) 3.28 2 1 3.0 0.00 1.0e+00 CAMKMT GPX1
Impedance of leg (left) 1.19 2 1 3.0 0.00 1.0e+00 C12orf65 GPX1
Leg predicted mass (left) 2.29 3 1 3.0 0.00 1.0e+00 C12orf65 GPX1 NUDT16L1
Trunk fat mass 1.72 2 0 0.0 0.00 1.0e+00 GPX1 NUDT16L1
Waist circumference 1.61 2 0 0.0 0.00 1.0e+00 GPX1 NUDT16L1
Frequency of tenseness / restlessness in last 2 weeks 2.98 1 0 0.0 0.00 1.0e+00 GPX1
Forced vital capacity (FVC) 2.58 2 1 3.0 0.00 1.0e+00 GPX1 NUDT16L1
Qualifications: None of the above 12.85 6 4 12.1 -1.00 1.8e-05 C12orf65 CAMKMT GPX1 NUDT16L1 ST3GAL3 TSGA10
Mouth/teeth dental problems 2.60 1 0 0.0 0.00 1.0e+00 ELK4
Allergy 2.20 1 1 3.0 0.00 1.0e+00 C12orf65
Pain all over the body in last month 3.39 1 0 0.0 0.00 1.0e+00 GPX1
Fluid intelligence score 7.17 5 1 3.0 0.97 7.3e-03 C12orf65 CAMKMT DISP2 GPX1 ST3GAL3
Illnesses of siblings 3.97 1 0 0.0 0.00 1.0e+00 ST3GAL3
Neuroticism score 2.39 1 1 3.0 0.00 1.0e+00 GPX1
Weight 2.21 3 1 3.0 0.00 1.0e+00 C12orf65 GPX1 NUDT16L1
Impedance of arm (right) 2.49 1 1 3.0 0.00 1.0e+00 GPX1
Arm fat percentage (right) 2.31 2 1 3.0 0.00 1.0e+00 CAMKMT GPX1
Trunk fat-free mass 2.45 3 1 3.0 0.00 1.0e+00 C12orf65 GPX1 NUDT16L1
Hip circumference 2.51 3 2 6.1 0.00 1.0e+00 C12orf65 GPX1 NUDT16L1
Alcohol intake versus 10 years previously 4.60 3 0 0.0 0.00 1.0e+00 CAMKMT GPX1 ST3GAL3
Father's age at death 4.25 1 0 0.0 0.00 1.0e+00 GPX1
Frequency of tiredness / lethargy in last 2 weeks 2.47 1 0 0.0 0.00 1.0e+00 GPX1
Forced expiratory volume in 1-second (FEV1) 2.54 2 1 3.0 0.00 1.0e+00 GPX1 NUDT16L1
Qualifications: A levels/AS levels or equivalent 13.29 6 4 12.1 0.98 6.4e-04 C12orf65 CAMKMT DISP2 GPX1 NUDT16L1 ST3GAL3
Mouth/teeth dental problems: Dentures 3.32 1 0 0.0 0.00 1.0e+00 GPX1
Prospective memory result 3.37 1 0 0.0 0.00 1.0e+00 CAMKMT
Lung cancer (father) 1.71 1 0 0.0 0.00 1.0e+00 GPX1
Forced expiratory volume in 1-second (FEV1), Best measure 2.91 3 1 3.0 0.00 1.0e+00 GPX1 NUDT16L1 ST3GAL3
Impedance of arm (left) 2.79 1 1 3.0 0.00 1.0e+00 GPX1
Arm fat mass (right) 2.37 3 1 3.0 0.00 1.0e+00 CAMKMT GPX1 NUDT16L1
Trunk predicted mass 2.46 2 1 3.0 0.00 1.0e+00 C12orf65 NUDT16L1
Standing height 4.00 7 5 15.2 0.78 3.8e-02 C12orf65 CAMKMT DISP2 ELK4 GPX1 NUDT16L1 TSGA10
Exposure to tobacco smoke at home 3.02 1 0 0.0 0.00 1.0e+00 GPX1
Breastfed as a baby 2.45 1 0 0.0 0.00 1.0e+00 C12orf65
Seen doctor (GP) for nerves, anxiety, tension or depression 2.81 1 0 0.0 0.00 1.0e+00 GPX1
Ever highly irritable/argumentative for 2 days 3.42 2 0 0.0 0.00 1.0e+00 C12orf65 GPX1
Medication: Paracetamol 4.12 2 1 3.0 0.00 1.0e+00 GPX1 ST3GAL3
Forced vital capacity (FVC), Best measure 3.05 4 1 3.0 0.99 1.5e-02 CAMKMT GPX1 NUDT16L1 ST3GAL3
Body fat percentage 2.17 2 1 3.0 0.00 1.0e+00 CAMKMT GPX1
Leg fat percentage (right) 3.59 2 1 3.0 0.00 1.0e+00 CAMKMT GPX1
Arm fat-free mass (right) 2.25 3 1 3.0 0.00 1.0e+00 C12orf65 GPX1 NUDT16L1
Number of full brothers 3.25 1 0 0.0 0.00 1.0e+00 GPX1
Wheeze or whistling in the chest in last year 2.28 1 0 0.0 0.00 1.0e+00 GPX1
Age at first live birth 5.17 1 1 3.0 0.00 1.0e+00 GPX1
Health satisfaction 2.04 1 0 0.0 0.00 1.0e+00 GPX1
Qualifications: College or University degree 9.64 5 3 9.1 0.96 9.5e-03 C12orf65 CAMKMT GPX1 ST3GAL3 TSGA10
Medication for pain relief, constipation, heartburn 5.38 3 0 0.0 0.00 1.0e+00 C12orf65 GPX1 NUDT16L1
Neck or shoulder pain in last month 2.54 1 0 0.0 0.00 1.0e+00 GPX1
Medication: Seretide 50 evohaler 2.20 1 0 0.0 0.00 1.0e+00 GPX1
Whole body fat mass 2.14 2 1 3.0 0.00 1.0e+00 GPX1 NUDT16L1
Leg fat mass (right) 2.73 2 1 3.0 0.00 1.0e+00 CAMKMT GPX1
Arm predicted mass (right) 2.18 3 1 3.0 0.00 1.0e+00 C12orf65 GPX1 NUDT16L1
Pulse rate, automated reading 1.57 2 0 0.0 0.00 1.0e+00 GPX1 NUDT16L1
Alcohol intake frequency. 2.58 1 0 0.0 0.00 1.0e+00 C12orf65
Comparative height size at age 10 3.98 5 2 6.1 0.97 6.4e-03 C12orf65 CAMKMT ELK4 GPX1 NUDT16L1
Overall health rating 5.00 1 1 3.0 0.00 1.0e+00 GPX1
Chest pain or discomfort 2.40 1 0 0.0 0.00 1.0e+00 GPX1
Had major operations 2.15 1 0 0.0 0.00 1.0e+00 GPX1
Age at last live birth 5.15 1 1 3.0 0.00 1.0e+00 GPX1
Hypertension (Self-reported) 2.50 1 1 3.0 0.00 1.0e+00 NUDT16L1
Illnesses of siblings: Diabetes 4.58 1 0 0.0 0.00 1.0e+00 TSGA10
Forced expiratory volume in 1-second (FEV1), predicted 3.19 1 0 0.0 0.00 1.0e+00 NUDT16L1
Whole body fat-free mass 2.42 3 1 3.0 0.00 1.0e+00 C12orf65 GPX1 NUDT16L1
Leg fat-free mass (right) 2.29 3 1 3.0 0.00 1.0e+00 C12orf65 GPX1 NUDT16L1
Arm fat percentage (left) 2.17 2 1 3.0 0.00 1.0e+00 CAMKMT GPX1
Average weekly red wine intake 5.55 2 1 3.0 0.00 1.0e+00 C12orf65 CAMKMT
Mood swings 4.40 1 1 3.0 0.00 1.0e+00 GPX1
Loneliness, isolation 3.64 1 1 3.0 0.00 1.0e+00 GPX1
Qualifications: nursing, teaching 6.90 3 1 3.0 0.00 1.0e+00 C12orf65 NUDT16L1 ST3GAL3
Medication for cholesterol 4.36 1 1 3.0 0.00 1.0e+00 NUDT16L1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.83 1 0 0.0 0.00 1.0e+00 GPX1
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.52 1 0 0.0 0.00 1.0e+00 DISP2
Whole body water mass 2.46 3 1 3.0 0.00 1.0e+00 C12orf65 GPX1 NUDT16L1
Leg predicted mass (right) 2.28 3 1 3.0 0.00 1.0e+00 C12orf65 GPX1 NUDT16L1
Arm fat mass (left) 2.28 3 1 3.0 0.00 1.0e+00 CAMKMT GPX1 NUDT16L1
Number of self-reported non-cancer illnesses 3.77 1 0 0.0 0.00 1.0e+00 NUDT16L1
Miserableness 5.04 1 1 3.0 0.00 1.0e+00 GPX1
Guilty feelings 2.42 1 0 0.0 0.00 1.0e+00 GPX1
Financial situation satisfaction 4.46 1 1 3.0 0.00 1.0e+00 GPX1
Medication: Blood pressure 3.51 1 1 3.0 0.00 1.0e+00 NUDT16L1
Medication: Paracetamol 3.99 2 1 3.0 0.00 1.0e+00 GPX1 ST3GAL3
Basal metabolic rate 2.47 3 2 6.1 0.00 1.0e+00 C12orf65 GPX1 NUDT16L1
Leg fat percentage (left) 3.89 2 2 6.1 0.00 1.0e+00 CAMKMT GPX1
Arm fat-free mass (left) 2.39 3 2 6.1 0.00 1.0e+00 C12orf65 GPX1 NUDT16L1
Number of operations (self-reported) 2.44 1 0 0.0 0.00 1.0e+00 GPX1
Irritability 2.16 1 0 0.0 0.00 1.0e+00 GPX1
Age started oral contraceptive pill 3.29 1 0 0.0 0.00 1.0e+00 GPX1
Diastolic blood pressure, automated reading 4.50 3 1 3.0 0.00 1.0e+00 C12orf65 GPX1 NUDT16L1
Vascular/heart problems diagnosed by doctor 3.25 2 1 3.0 0.00 1.0e+00 ELK4 NUDT16L1
Cholesterol lowering medication 2.96 1 0 0.0 0.00 1.0e+00 NUDT16L1
Pain experienced in last month 4.23 1 1 3.0 0.00 1.0e+00 GPX1
Pack years of smoking 2.94 1 0 0.0 0.00 1.0e+00 GPX1
Impedance of whole body 2.03 1 1 3.0 0.00 1.0e+00 GPX1
Leg fat mass (left) 2.90 2 1 3.0 0.00 1.0e+00 CAMKMT GPX1
Arm predicted mass (left) 2.34 3 2 6.1 0.00 1.0e+00 C12orf65 GPX1 NUDT16L1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0573 1.66
GTEx Adipose Visceral Omentum 3 0.1473 1.67
GTEx Adrenal Gland 0 0.0000 1.45
GTEx Artery Aorta 4 0.1344 1.65
GTEx Artery Coronary 0 0.0000 1.61
GTEx Artery Tibial 3 0.0798 1.66
GTEx Brain Caudate basal ganglia 0 0.0000 1.56
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.68
GTEx Brain Cerebellum 0 0.0000 1.69
GTEx Brain Cortex 0 0.0000 1.59
GTEx Brain Frontal Cortex BA9 1 0.1082 1.57
GTEx Brain Hippocampus 0 0.0000 1.59
GTEx Brain Hypothalamus 0 0.0000 1.64
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.52
GTEx Brain Putamen basal ganglia 0 0.0000 1.54
GTEx Breast Mammary Tissue 2 0.1013 1.74
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.54
GTEx Breast Mammary Tissue (Female) 3 0.1825 1.68
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.59
GTEx Cells Transformed fibroblasts 6 0.1429 1.65
GTEx Colon Sigmoid 1 0.0684 1.71
GTEx Colon Transverse 3 0.1453 1.65
GTEx Esophagus Gastroesophageal Junction 1 0.0692 1.71
GTEx Esophagus Mucosa 3 0.0904 1.70
GTEx Esophagus Muscularis 4 0.1238 1.73
GTEx Heart Atrial Appendage 0 0.0000 1.71
GTEx Heart Left Ventricle 2 0.1307 1.65
GTEx Liver 0 0.0000 1.60
GTEx Lung 3 0.1044 1.65
GTEx Muscle Skeletal 2 0.0692 1.63
GTEx Nerve Tibial 5 0.1157 1.65
GTEx Ovary 0 0.0000 1.58
GTEx Pancreas 4 0.2451 1.77
GTEx Pituitary 0 0.0000 1.60
GTEx Prostate 0 0.0000 1.55
GTEx Skin Not Sun Exposed Suprapubic 3 0.1220 1.65
GTEx Skin Sun Exposed Lower leg 4 0.1099 1.63
GTEx Small Intestine Terminal Ileum 1 0.2169 1.63
GTEx Spleen 0 0.0000 1.70
GTEx Stomach 1 0.0688 1.70
GTEx Testis 3 0.0951 1.63
GTEx Thyroid 4 0.1000 1.72
GTEx Uterus 0 0.0000 1.63
GTEx Vagina 0 0.0000 1.46
GTEx Whole Blood 0 0.0000 1.52
METSIM Adipose 4 0.0868 1.58
NTR Blood 0 0.0000 1.54
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.66
YFS Blood 2 0.0433 1.47
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.52
TCGA Breast Tumor 1 0.1304 1.66
TCGA Breast Normal 3 0.0713 1.48
TCGA Ovarian Tumor 2 0.0684 1.55
TCGA Prostate Tumor 2 0.0578 1.57