Hub : Traits :

Medication: Aspirin

18 significantly associated models · 11 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 109098737 110517617 2 1 6.3e-10 4.6e-10 1.0e+00 100 PSRC1
2 4 52683607 53598975 3 1 3.0e-08 9.1e-08 6.8e-02 88 SGCB
3 6 160071844 161571560 1 1 1.5e-08 7.1e-07 7.9e-06 19 SLC22A3
4 9 21303958 22819407 2 1 7.4e-11 7.4e-18 1.7e-08 57 CDKN2B
5 15 90730363 92135418 1 1 1.2e-07 1.0e-06 9.8e-01 100 FES
6 17 16218025 17614947 1 1 1.0e-07 1.8e-04 3.3e-03 38 RP11-416I2.1
7 20 62018747 62912463 1 1 3.4e-07 9.5e-07 3.2e-01 96 OPRL1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.05 1 0 0.0 0.00 1.0e+00 FES
Irritable Bowel Disease (IBD) 1.61 2 0 0.0 0.00 1.0e+00 FES OPRL1
Ulcerative Colitis (UC) 2.32 1 0 0.0 0.00 1.0e+00 OPRL1
Major Depression (MDD) 3.84 1 0 0.0 0.00 1.0e+00 FES
Reaction Time 1.20 1 0 0.0 0.00 1.0e+00 FES
Breast Cancer 3.58 3 0 0.0 0.00 1.0e+00 CDKN2B FES OPRL1
Ovarian Cancer 2.44 1 0 0.0 0.00 1.0e+00 OPRL1
Body Mass Index (BMI) (2010) 3.54 2 0 0.0 0.00 1.0e+00 OPRL1 SGCB
Coronary Artery Disease (CAD) 17.85 4 2 6.1 -0.96 4.0e-02 CDKN2B FES PSRC1 SLC22A3
HDL Cholesterol 2.64 1 0 0.0 0.00 1.0e+00 PSRC1
LDL Cholesterol 72.48 2 1 3.0 0.00 1.0e+00 OPRL1 PSRC1
Rheumatoid Arthritis 2.13 1 0 0.0 0.00 1.0e+00 OPRL1
Schizophrenia 3.04 1 1 3.0 0.00 1.0e+00 FES
Type 2 Diabetes (T2D) 3.64 1 0 0.0 0.00 1.0e+00 CDKN2B
Blood Eosinophil Count 0.65 1 0 0.0 0.00 1.0e+00 OPRL1
Blood Platelet Count 1.02 5 0 0.0 -0.72 1.7e-01 CDKN2B OPRL1 RP11-416I2.1 SGCB SLC22A3
Blood Red Count 0.49 3 0 0.0 0.00 1.0e+00 CDKN2B FES RP11-416I2.1
Blood White Count 2.22 5 1 3.0 -0.65 2.3e-01 CDKN2B FES OPRL1 PSRC1 SGCB
Heel T-Score 0.57 1 0 0.0 0.00 1.0e+00 PSRC1
BMI 1.73 3 0 0.0 0.00 1.0e+00 OPRL1 SGCB SLC22A3
Height 1.25 5 4 12.1 0.37 5.4e-01 FES OPRL1 PSRC1 SGCB SLC22A3
Waist Hip Ratio (WHR) 4.20 3 2 6.1 0.00 1.0e+00 OPRL1 RP11-416I2.1 SLC22A3
Systolic Blood Pressure 11.68 5 2 6.1 -0.82 9.1e-02 FES OPRL1 RP11-416I2.1 SGCB SLC22A3
Smoking Status 2.35 2 0 0.0 0.00 1.0e+00 FES PSRC1
Allergy or Eczema 1.84 2 0 0.0 0.00 1.0e+00 FES SLC22A3
Cardiovascular Disease 14.63 5 3 9.1 -0.98 3.8e-03 FES OPRL1 PSRC1 SGCB SLC22A3
Respiratory disease 1.93 1 0 0.0 0.00 1.0e+00 FES
Type 2 Diabetes (T2D) 4.04 4 0 0.0 -0.97 2.5e-02 CDKN2B OPRL1 SGCB SLC22A3
Lung FEV1/FVC ratio 1.08 1 1 3.0 0.00 1.0e+00 PSRC1
Lung FVC 1.35 1 1 3.0 0.00 1.0e+00 OPRL1
Neuroticism 0.75 1 0 0.0 0.00 1.0e+00 FES
Chronotype (morning person) 1.22 1 0 0.0 0.00 1.0e+00 SGCB
Hair Pigment 0.66 3 2 6.1 0.00 1.0e+00 CDKN2B FES OPRL1
Hand grip strength (left) 1.48 1 0 0.0 0.00 1.0e+00 FES
Number of treatments/medications taken 4.73 3 1 3.0 0.00 1.0e+00 FES PSRC1 SGCB
Sensitivity / hurt feelings 2.12 1 0 0.0 0.00 1.0e+00 FES
Hearing difficulty/problems: Yes 2.17 2 0 0.0 0.00 1.0e+00 PSRC1 SGCB
Other serious medical condition/disability diagnosed by doctor 1.18 1 0 0.0 0.00 1.0e+00 PSRC1
Systolic blood pressure, automated reading 9.37 3 2 6.1 0.00 1.0e+00 FES OPRL1 SGCB
Angina 25.75 5 4 12.1 0.98 2.2e-03 CDKN2B FES OPRL1 PSRC1 SLC22A3
Medication: Metformin 4.40 2 0 0.0 0.00 1.0e+00 CDKN2B SGCB
Severe depression (siblings) 1.99 1 0 0.0 0.00 1.0e+00 FES
Impedance of leg (right) 2.23 3 1 3.0 0.00 1.0e+00 FES OPRL1 RP11-416I2.1
Leg fat-free mass (left) 2.04 4 0 0.0 -0.57 4.3e-01 FES PSRC1 SGCB SLC22A3
Trunk fat percentage 1.79 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
High blood pressure 9.62 2 2 6.1 0.00 1.0e+00 FES OPRL1
Hayfever, allergic rhinitis or eczema 1.78 1 0 0.0 0.00 1.0e+00 FES
Medication: Atenolol 9.78 3 1 3.0 0.00 1.0e+00 CDKN2B FES PSRC1
Sitting height 0.69 1 0 0.0 0.00 1.0e+00 SLC22A3
High blood pressure (mother) 8.23 1 1 3.0 0.00 1.0e+00 FES
Body mass index (BMI) 1.12 1 0 0.0 0.00 1.0e+00 SGCB
Impedance of leg (left) 2.09 3 1 3.0 0.00 1.0e+00 FES OPRL1 RP11-416I2.1
Leg predicted mass (left) 2.05 4 0 0.0 -0.56 4.4e-01 FES PSRC1 SGCB SLC22A3
Trunk fat mass 1.98 2 1 3.0 0.00 1.0e+00 SGCB SLC22A3
Waist circumference 1.15 1 0 0.0 0.00 1.0e+00 SGCB
Number of incorrect matches in round 2.22 1 0 0.0 0.00 1.0e+00 FES
Alcohol usually taken with meals 2.26 1 0 0.0 0.00 1.0e+00 FES
Forced vital capacity (FVC) 0.74 1 0 0.0 0.00 1.0e+00 OPRL1
Mouth/teeth dental problems 1.41 1 0 0.0 0.00 1.0e+00 CDKN2B
Heart attack 19.71 5 4 12.1 0.99 4.9e-04 CDKN2B FES OPRL1 PSRC1 SLC22A3
Allergy 1.69 1 0 0.0 0.00 1.0e+00 FES
Diabetes (self-reported) 3.73 2 0 0.0 0.00 1.0e+00 OPRL1 SGCB
Medication: Ramipril 6.64 3 0 0.0 0.00 1.0e+00 FES OPRL1 SLC22A3
Medication: Simvastatin 26.31 7 3 9.1 0.92 3.9e-03 CDKN2B FES OPRL1 PSRC1 RP11-416I2.1 SGCB SLC22A3
Illnesses of siblings 5.08 2 0 0.0 0.00 1.0e+00 FES SGCB
Weight 1.87 2 1 3.0 0.00 1.0e+00 SGCB SLC22A3
Impedance of arm (right) 1.60 4 0 0.0 0.29 7.1e-01 CDKN2B OPRL1 PSRC1 RP11-416I2.1
Arm fat percentage (right) 1.48 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Trunk fat-free mass 2.10 4 1 3.0 -0.58 4.2e-01 FES PSRC1 SGCB SLC22A3
Hip circumference 2.05 3 1 3.0 0.00 1.0e+00 OPRL1 SGCB SLC22A3
Alcohol intake versus 10 years previously 2.07 1 0 0.0 0.00 1.0e+00 SGCB
Father's age at death 8.46 4 1 3.0 -0.99 6.3e-03 CDKN2B FES PSRC1 SGCB
Number of live births 1.98 1 0 0.0 0.00 1.0e+00 FES
Forced expiratory volume in 1-second (FEV1) 1.02 1 0 0.0 0.00 1.0e+00 OPRL1
Asthma 1.17 1 0 0.0 0.00 1.0e+00 FES
Medication: Ibuprofen (e.g. Nurofen) 1.59 1 0 0.0 0.00 1.0e+00 SLC22A3
Medication: Cholesterol lowering 34.36 6 3 9.1 0.92 9.3e-03 CDKN2B FES OPRL1 PSRC1 SGCB SLC22A3
Prospective memory result 2.31 1 0 0.0 0.00 1.0e+00 SGCB
Illnesses of mother 7.01 2 1 3.0 0.00 1.0e+00 CDKN2B FES
Pulse wave Arterial Stiffness index 3.33 2 0 0.0 0.00 1.0e+00 CDKN2B FES
Impedance of arm (left) 1.62 3 0 0.0 0.00 1.0e+00 OPRL1 PSRC1 RP11-416I2.1
Arm fat mass (right) 1.82 2 1 3.0 0.00 1.0e+00 SGCB SLC22A3
Trunk predicted mass 2.09 4 1 3.0 -0.58 4.2e-01 FES PSRC1 SGCB SLC22A3
Standing height 1.06 3 1 3.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3
Breastfed as a baby 2.38 1 0 0.0 0.00 1.0e+00 FES
Hair/balding pattern: Pattern 4 1.33 1 0 0.0 0.00 1.0e+00 FES
Birth weight of first child 5.57 2 1 3.0 0.00 1.0e+00 FES OPRL1
Headache pain in last month 2.00 1 0 0.0 0.00 1.0e+00 FES
Medication for cholesterol, blood pressure or diabetes 17.83 3 3 9.1 0.00 1.0e+00 FES OPRL1 PSRC1
Glaucoma (self-reported) 6.39 1 1 3.0 0.00 1.0e+00 CDKN2B
Medication: Amlodipine 3.97 1 1 3.0 0.00 1.0e+00 FES
Birth weight 3.33 1 1 3.0 0.00 1.0e+00 FES
High blood pressure (siblings) 5.83 2 1 3.0 0.00 1.0e+00 FES SGCB
Body fat percentage 1.54 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Leg fat percentage (right) 0.96 1 0 0.0 0.00 1.0e+00 SGCB
Arm fat-free mass (right) 1.93 3 0 0.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.61 1 0 0.0 0.00 1.0e+00 RP11-416I2.1
Pulse wave peak to peak time 3.52 2 0 0.0 0.00 1.0e+00 CDKN2B FES
Medication for pain relief, constipation, heartburn 2.20 1 0 0.0 0.00 1.0e+00 PSRC1
Medication: Blood pressure 8.83 2 1 3.0 0.00 1.0e+00 FES OPRL1
Angina (self-reported) 26.76 5 4 12.1 0.99 1.6e-03 CDKN2B FES OPRL1 PSRC1 SLC22A3
Medication: Ibuprofen 2.25 1 0 0.0 0.00 1.0e+00 SLC22A3
Mean time to correctly identify matches 1.59 1 0 0.0 0.00 1.0e+00 FES
Heart disease (mother) 11.40 3 2 6.1 0.00 1.0e+00 CDKN2B FES SLC22A3
Whole body fat mass 1.89 2 1 3.0 0.00 1.0e+00 SGCB SLC22A3
Leg fat mass (right) 1.50 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Arm predicted mass (right) 2.01 3 0 0.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3
Comparative height size at age 10 1.45 4 0 0.0 -0.66 3.4e-01 FES PSRC1 SGCB SLC22A3
Chest pain or discomfort 3.28 1 0 0.0 0.00 1.0e+00 CDKN2B
Hypertension (Self-reported) 9.69 3 1 3.0 0.00 1.0e+00 FES OPRL1 SLC22A3
Illnesses of father: Heart disease 26.40 5 4 12.1 0.99 1.5e-03 CDKN2B FES OPRL1 PSRC1 SLC22A3
Whole body fat-free mass 2.06 4 0 0.0 -0.58 4.2e-01 FES PSRC1 SGCB SLC22A3
Leg fat-free mass (right) 2.12 4 0 0.0 -0.61 3.9e-01 FES PSRC1 SGCB SLC22A3
Arm fat percentage (left) 1.34 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Average weekly red wine intake 2.78 1 0 0.0 0.00 1.0e+00 SLC22A3
Handedness (chirality/laterality): Left-handed 1.73 1 0 0.0 0.00 1.0e+00 FES
Long-standing illness, disability or infirmity 2.83 1 0 0.0 0.00 1.0e+00 CDKN2B
Diabetes diagnosed by doctor 4.31 3 0 0.0 0.00 1.0e+00 OPRL1 SGCB SLC22A3
Medication for cholesterol 10.04 5 2 6.1 -0.97 5.0e-03 CDKN2B FES OPRL1 PSRC1 SLC22A3
Mineral and other dietary supplements 2.02 1 0 0.0 0.00 1.0e+00 SLC22A3
Breast cancer (self-reported) 2.08 1 0 0.0 0.00 1.0e+00 CDKN2B
Asthma (self-reported) 1.15 1 0 0.0 0.00 1.0e+00 FES
Osteoporosis (self-reported) 1.64 1 0 0.0 0.00 1.0e+00 SLC22A3
Medication: Aspirin 23.48 7 5 15.2 1.00 3.0e-07 CDKN2B FES OPRL1 PSRC1 RP11-416I2.1 SGCB SLC22A3
Medication: Gliclazide 2.47 1 0 0.0 0.00 1.0e+00 CDKN2B
Illnesses of father: None of the above (group 1) 13.69 4 2 6.1 -0.98 1.5e-02 CDKN2B FES RP11-416I2.1 SLC22A3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.49 1 0 0.0 0.00 1.0e+00 OPRL1
Whole body water mass 2.03 4 0 0.0 -0.58 4.2e-01 FES PSRC1 SGCB SLC22A3
Leg predicted mass (right) 2.12 4 0 0.0 -0.61 3.9e-01 FES PSRC1 SGCB SLC22A3
Arm fat mass (left) 1.76 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Number of self-reported non-cancer illnesses 4.79 2 0 0.0 0.00 1.0e+00 OPRL1 SLC22A3
Eye problems/disorders: Glaucoma 8.76 1 1 3.0 0.00 1.0e+00 CDKN2B
Medication: Blood pressure 8.76 4 1 3.0 0.94 6.1e-02 FES OPRL1 SGCB SLC22A3
Supplements: Fish oil (including cod liver oil) 2.36 1 0 0.0 0.00 1.0e+00 SLC22A3
High cholesterol (Self-reported) 38.55 5 3 9.1 0.78 1.2e-01 FES OPRL1 PSRC1 RP11-416I2.1 SLC22A3
Medication: Bendroflumethiazide 3.88 1 1 3.0 0.00 1.0e+00 FES
Medication: Paracetamol 2.50 1 0 0.0 0.00 1.0e+00 RP11-416I2.1
Medication: Lisinopril 3.19 1 0 0.0 0.00 1.0e+00 FES
Medication: Atorvastatin 22.03 3 2 6.1 0.00 1.0e+00 CDKN2B PSRC1 SLC22A3
Illnesses of father: High blood pressure 6.22 1 1 3.0 0.00 1.0e+00 FES
Ever smoked 1.33 1 0 0.0 0.00 1.0e+00 FES
Basal metabolic rate 2.04 4 0 0.0 -0.52 4.8e-01 FES PSRC1 SGCB SLC22A3
Leg fat percentage (left) 0.82 1 0 0.0 0.00 1.0e+00 SGCB
Arm fat-free mass (left) 1.80 3 0 0.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3
Risk taking 2.20 1 0 0.0 0.00 1.0e+00 FES
Age started oral contraceptive pill 2.06 1 0 0.0 0.00 1.0e+00 FES
Diastolic blood pressure, automated reading 6.12 2 1 3.0 0.00 1.0e+00 CDKN2B FES
Vascular/heart problems diagnosed by doctor 12.57 4 2 6.1 -0.95 5.4e-02 CDKN2B FES OPRL1 SLC22A3
Cholesterol lowering medication 22.71 5 3 9.1 0.95 1.3e-02 CDKN2B OPRL1 PSRC1 SGCB SLC22A3
Basal cell carcinoma (self-reported) 3.60 1 0 0.0 0.00 1.0e+00 CDKN2B
Heart attack/myocardial infarction (self-reported) 19.98 5 4 12.1 0.99 5.6e-04 CDKN2B FES OPRL1 PSRC1 SLC22A3
Heart disease (siblings) 8.85 4 0 0.0 0.97 3.2e-02 CDKN2B FES PSRC1 SLC22A3
Impedance of whole body 1.92 4 0 0.0 -0.57 4.3e-01 FES OPRL1 PSRC1 RP11-416I2.1
Leg fat mass (left) 1.48 2 0 0.0 0.00 1.0e+00 SGCB SLC22A3
Arm predicted mass (left) 2.00 3 0 0.0 0.00 1.0e+00 PSRC1 SGCB SLC22A3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.33
GTEx Adipose Visceral Omentum 0 0.0000 1.34
GTEx Adrenal Gland 0 0.0000 1.45
GTEx Artery Aorta 0 0.0000 1.37
GTEx Artery Coronary 0 0.0000 1.29
GTEx Artery Tibial 0 0.0000 1.36
GTEx Brain Caudate basal ganglia 0 0.0000 1.34
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.32
GTEx Brain Cerebellum 0 0.0000 1.32
GTEx Brain Cortex 0 0.0000 1.41
GTEx Brain Frontal Cortex BA9 0 0.0000 1.36
GTEx Brain Hippocampus 0 0.0000 1.29
GTEx Brain Hypothalamus 0 0.0000 1.35
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.30
GTEx Brain Putamen basal ganglia 0 0.0000 1.30
GTEx Breast Mammary Tissue 1 0.0507 1.34
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.26
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.32
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.38
GTEx Cells Transformed fibroblasts 1 0.0238 1.32
GTEx Colon Sigmoid 0 0.0000 1.32
GTEx Colon Transverse 0 0.0000 1.35
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.37
GTEx Esophagus Mucosa 1 0.0301 1.33
GTEx Esophagus Muscularis 0 0.0000 1.32
GTEx Heart Atrial Appendage 1 0.0633 1.36
GTEx Heart Left Ventricle 0 0.0000 1.33
GTEx Liver 1 0.1395 1.37
GTEx Lung 1 0.0348 1.33
GTEx Muscle Skeletal 1 0.0346 1.35
GTEx Nerve Tibial 0 0.0000 1.31
GTEx Ovary 0 0.0000 1.42
GTEx Pancreas 0 0.0000 1.37
GTEx Pituitary 0 0.0000 1.35
GTEx Prostate 0 0.0000 1.34
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.36
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.31
GTEx Small Intestine Terminal Ileum 0 0.0000 1.43
GTEx Spleen 0 0.0000 1.49
GTEx Stomach 0 0.0000 1.44
GTEx Testis 1 0.0317 1.31
GTEx Thyroid 0 0.0000 1.37
GTEx Uterus 0 0.0000 1.29
GTEx Vagina 0 0.0000 1.42
GTEx Whole Blood 1 0.0502 1.36
METSIM Adipose 0 0.0000 1.26
NTR Blood 0 0.0000 1.31
ROSMAP Brain Pre-frontal Cortex 1 0.0228 1.33
YFS Blood 0 0.0000 1.27
CommonMind Brain Pre-frontal Cortex 4 0.0744 1.31
TCGA Breast Tumor 0 0.0000 1.32
TCGA Breast Normal 1 0.0238 1.27
TCGA Ovarian Tumor 2 0.0684 1.27
TCGA Prostate Tumor 0 0.0000 1.31