Hub : Traits :

Heart attack

39 significantly associated models · 12 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 109098737 110517617 2 1 5.7e-09 5.2e-09 2.9e-01 97 PSRC1
2 1 222096959 223567803 3 1 1.1e-11 1.4e-11 1.0e+00 100 RP11-378J18.8
3 6 12020241 13990267 2 1 5.0e-16 5.4e-16 4.7e-02 94 RP1-257A7.5
4 6 159820779 161571560 2 2 5.1e-09 8.9e-12 2.2e-08 33 RP11-288H12.3 SLC22A3
5 9 21303958 22819407 2 2 1.7e-15 1.1e-30 1.5e-15 52 CDKN2B CDKN2B-AS1
6 15 90730363 92135418 1 1 2.0e-07 9.0e-07 6.4e-01 99 FES

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.04 1 0 0.0 0.00 1.0e+00 FES
Irritable Bowel Disease (IBD) 0.74 1 0 0.0 0.00 1.0e+00 FES
Major Depression (MDD) 2.96 1 0 0.0 0.00 1.0e+00 FES
Breast Cancer 3.30 3 0 0.0 0.00 1.0e+00 CDKN2B CDKN2B-AS1 FES
Coronary Artery Disease (CAD) 31.38 6 4 12.1 -0.99 3.2e-04 CDKN2B CDKN2B-AS1 FES PSRC1 RP1-257A7.5 SLC22A3
HDL Cholesterol 2.73 1 0 0.0 0.00 1.0e+00 PSRC1
LDL Cholesterol 65.98 2 1 3.0 0.00 1.0e+00 PSRC1 RP11-288H12.3
Schizophrenia 2.82 1 1 3.0 0.00 1.0e+00 FES
Triglycerides 2.49 1 0 0.0 0.00 1.0e+00 RP11-288H12.3
Type 2 Diabetes (T2D) 3.16 1 0 0.0 0.00 1.0e+00 CDKN2B
Blood Platelet Count 0.60 2 0 0.0 0.00 1.0e+00 CDKN2B SLC22A3
Blood Red Count 0.66 2 0 0.0 0.00 1.0e+00 FES RP1-257A7.5
Blood White Count 1.58 3 1 3.0 0.00 1.0e+00 CDKN2B FES RP1-257A7.5
Heel T-Score 0.53 1 1 3.0 0.00 1.0e+00 PSRC1
BMI 1.22 2 0 0.0 0.00 1.0e+00 RP1-257A7.5 SLC22A3
Height 1.02 4 4 12.1 1.00 3.0e-03 FES PSRC1 RP11-288H12.3 SLC22A3
Waist Hip Ratio (WHR) 2.72 3 1 3.0 0.00 1.0e+00 RP11-288H12.3 RP11-378J18.8 SLC22A3
Systolic Blood Pressure 9.29 3 2 6.1 0.00 1.0e+00 FES RP1-257A7.5 SLC22A3
Smoking Status 2.40 2 0 0.0 0.00 1.0e+00 FES PSRC1
Allergy or Eczema 1.64 1 0 0.0 0.00 1.0e+00 FES
Cardiovascular Disease 10.83 4 2 6.1 -0.99 1.5e-02 FES PSRC1 RP11-288H12.3 SLC22A3
Respiratory disease 1.91 1 0 0.0 0.00 1.0e+00 FES
Type 2 Diabetes (T2D) 1.87 1 0 0.0 0.00 1.0e+00 SLC22A3
Lung FEV1/FVC ratio 1.51 2 1 3.0 0.00 1.0e+00 PSRC1 RP11-378J18.8
Lung FVC 0.76 1 0 0.0 0.00 1.0e+00 RP11-378J18.8
Neuroticism 1.21 2 0 0.0 0.00 1.0e+00 FES RP1-257A7.5
Hair Pigment 0.63 3 3 9.1 0.00 1.0e+00 CDKN2B CDKN2B-AS1 FES
Hand grip strength (left) 2.47 2 0 0.0 0.00 1.0e+00 FES RP1-257A7.5
Number of treatments/medications taken 4.05 2 1 3.0 0.00 1.0e+00 FES PSRC1
Sensitivity / hurt feelings 1.73 1 0 0.0 0.00 1.0e+00 FES
Hearing difficulty/problems: Yes 1.82 1 0 0.0 0.00 1.0e+00 RP11-378J18.8
Other serious medical condition/disability diagnosed by doctor 1.42 1 0 0.0 0.00 1.0e+00 PSRC1
Systolic blood pressure, automated reading 7.02 2 2 6.1 0.00 1.0e+00 FES RP1-257A7.5
Angina 31.91 8 5 15.2 0.97 9.1e-05 CDKN2B CDKN2B-AS1 FES PSRC1 RP11-288H12.3 RP11-378J18.8 RP1-257A7.5 SLC22A3
Medication: Metformin 2.40 1 0 0.0 0.00 1.0e+00 CDKN2B
Impedance of leg (right) 1.79 3 1 3.0 0.00 1.0e+00 FES PSRC1 RP11-378J18.8
Leg fat-free mass (left) 1.46 2 0 0.0 0.00 1.0e+00 FES SLC22A3
Trunk fat percentage 1.74 2 0 0.0 0.00 1.0e+00 RP1-257A7.5 SLC22A3
Hand grip strength (right) 2.05 2 0 0.0 0.00 1.0e+00 PSRC1 RP1-257A7.5
High blood pressure 7.58 2 1 3.0 0.00 1.0e+00 FES RP1-257A7.5
Hayfever, allergic rhinitis or eczema 1.63 1 0 0.0 0.00 1.0e+00 FES
Multivitamins +/- minerals 2.11 1 0 0.0 0.00 1.0e+00 RP11-288H12.3
Medication: Atenolol 7.52 2 1 3.0 0.00 1.0e+00 CDKN2B FES
Sitting height 0.85 1 0 0.0 0.00 1.0e+00 SLC22A3
High blood pressure (mother) 8.07 2 1 3.0 0.00 1.0e+00 FES RP1-257A7.5
Body mass index (BMI) 0.77 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Impedance of leg (left) 1.55 2 1 3.0 0.00 1.0e+00 FES RP11-378J18.8
Leg predicted mass (left) 1.46 2 0 0.0 0.00 1.0e+00 FES SLC22A3
Trunk fat mass 1.72 2 0 0.0 0.00 1.0e+00 RP1-257A7.5 SLC22A3
Waist circumference 0.84 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Number of incorrect matches in round 1.44 1 0 0.0 0.00 1.0e+00 FES
Past tobacco smoking 2.94 1 0 0.0 0.00 1.0e+00 CDKN2B-AS1
Alcohol usually taken with meals 1.73 1 0 0.0 0.00 1.0e+00 FES
Allergy 1.80 1 0 0.0 0.00 1.0e+00 FES
Medication: Ramipril 6.04 2 0 0.0 0.00 1.0e+00 FES SLC22A3
Medication: Simvastatin 19.45 5 2 6.1 0.95 1.2e-02 CDKN2B CDKN2B-AS1 FES PSRC1 SLC22A3
Illnesses of siblings 3.55 1 0 0.0 0.00 1.0e+00 FES
Weight 1.39 2 0 0.0 0.00 1.0e+00 RP1-257A7.5 SLC22A3
Impedance of arm (right) 1.00 2 0 0.0 0.00 1.0e+00 CDKN2B PSRC1
Arm fat percentage (right) 1.63 2 0 0.0 0.00 1.0e+00 RP1-257A7.5 SLC22A3
Trunk fat-free mass 1.34 2 0 0.0 0.00 1.0e+00 PSRC1 SLC22A3
Hip circumference 1.59 1 1 3.0 0.00 1.0e+00 SLC22A3
Father's age at death 8.87 4 1 3.0 -1.00 3.3e-03 CDKN2B CDKN2B-AS1 FES PSRC1
Number of live births 1.12 1 0 0.0 0.00 1.0e+00 FES
Asthma 1.31 1 0 0.0 0.00 1.0e+00 FES
Medication: Ibuprofen (e.g. Nurofen) 5.13 2 1 3.0 0.00 1.0e+00 RP1-257A7.5 SLC22A3
Medication: Cholesterol lowering 29.15 7 3 9.1 0.89 6.8e-03 CDKN2B CDKN2B-AS1 FES PSRC1 RP11-288H12.3 RP11-378J18.8 SLC22A3
Illnesses of mother 6.26 2 1 3.0 0.00 1.0e+00 CDKN2B FES
Pulse wave Arterial Stiffness index 5.13 2 0 0.0 0.00 1.0e+00 FES RP1-257A7.5
Impedance of arm (left) 0.65 1 0 0.0 0.00 1.0e+00 PSRC1
Arm fat mass (right) 1.50 2 0 0.0 0.00 1.0e+00 RP1-257A7.5 SLC22A3
Trunk predicted mass 1.33 2 0 0.0 0.00 1.0e+00 PSRC1 SLC22A3
Standing height 1.03 3 1 3.0 0.00 1.0e+00 PSRC1 RP11-288H12.3 SLC22A3
Breastfed as a baby 1.62 1 0 0.0 0.00 1.0e+00 FES
Hair/balding pattern: Pattern 4 1.51 1 0 0.0 0.00 1.0e+00 FES
Birth weight of first child 4.29 1 1 3.0 0.00 1.0e+00 FES
Medication: Paracetamol 2.81 1 1 3.0 0.00 1.0e+00 RP1-257A7.5
Headache pain in last month 6.09 2 1 3.0 0.00 1.0e+00 FES RP1-257A7.5
Medication for cholesterol, blood pressure or diabetes 13.23 3 2 6.1 0.00 1.0e+00 FES PSRC1 RP11-378J18.8
Glaucoma (self-reported) 8.04 2 1 3.0 0.00 1.0e+00 CDKN2B CDKN2B-AS1
Medication: Amlodipine 3.07 1 1 3.0 0.00 1.0e+00 FES
Birth weight 3.18 1 1 3.0 0.00 1.0e+00 FES
High blood pressure (siblings) 3.69 1 1 3.0 0.00 1.0e+00 FES
Body fat percentage 1.67 2 0 0.0 0.00 1.0e+00 RP1-257A7.5 SLC22A3
Leg fat percentage (right) 1.55 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Arm fat-free mass (right) 1.16 2 0 0.0 0.00 1.0e+00 PSRC1 SLC22A3
Pulse wave peak to peak time 5.06 2 0 0.0 0.00 1.0e+00 FES RP1-257A7.5
Qualifications: College or University degree 1.06 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Medication for pain relief, constipation, heartburn 3.20 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Medication: Blood pressure 6.98 1 1 3.0 0.00 1.0e+00 FES
Angina (self-reported) 33.07 8 5 15.2 0.97 6.8e-05 CDKN2B CDKN2B-AS1 FES PSRC1 RP11-288H12.3 RP11-378J18.8 RP1-257A7.5 SLC22A3
Migraine (self-reported) 6.44 1 1 3.0 0.00 1.0e+00 RP1-257A7.5
Medication: Ibuprofen 5.08 2 0 0.0 0.00 1.0e+00 RP1-257A7.5 SLC22A3
Mean time to correctly identify matches 1.91 1 0 0.0 0.00 1.0e+00 FES
Heart disease (mother) 15.48 7 2 6.1 0.98 1.2e-04 CDKN2B CDKN2B-AS1 FES RP11-288H12.3 RP11-378J18.8 RP1-257A7.5 SLC22A3
Whole body fat mass 1.65 2 0 0.0 0.00 1.0e+00 RP1-257A7.5 SLC22A3
Leg fat mass (right) 1.29 2 0 0.0 0.00 1.0e+00 RP1-257A7.5 SLC22A3
Arm predicted mass (right) 1.25 2 0 0.0 0.00 1.0e+00 PSRC1 SLC22A3
Pulse rate, automated reading 1.61 2 0 0.0 0.00 1.0e+00 RP11-378J18.8 RP1-257A7.5
Alcohol intake frequency. 2.25 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Comparative height size at age 10 1.30 3 0 0.0 0.00 1.0e+00 FES PSRC1 SLC22A3
Chest pain or discomfort 3.31 1 0 0.0 0.00 1.0e+00 CDKN2B
Medication: Aspirin 18.18 6 5 15.2 0.99 6.7e-05 CDKN2B CDKN2B-AS1 FES PSRC1 RP11-288H12.3 SLC22A3
Knee pain experienced in last month 1.28 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Hypertension (Self-reported) 7.73 3 1 3.0 0.00 1.0e+00 FES RP1-257A7.5 SLC22A3
Illnesses of father: Heart disease 32.81 8 6 18.2 0.97 7.7e-05 CDKN2B CDKN2B-AS1 FES PSRC1 RP11-288H12.3 RP11-378J18.8 RP1-257A7.5 SLC22A3
Smoking status: Previous 2.74 1 0 0.0 0.00 1.0e+00 CDKN2B-AS1
Whole body fat-free mass 1.35 3 0 0.0 0.00 1.0e+00 FES PSRC1 SLC22A3
Leg fat-free mass (right) 1.52 3 0 0.0 0.00 1.0e+00 FES PSRC1 SLC22A3
Arm fat percentage (left) 1.47 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Handedness (chirality/laterality): Left-handed 1.51 1 0 0.0 0.00 1.0e+00 FES
Long-standing illness, disability or infirmity 2.06 1 0 0.0 0.00 1.0e+00 CDKN2B
Diabetes diagnosed by doctor 1.76 1 0 0.0 0.00 1.0e+00 SLC22A3
Medication for cholesterol 7.23 3 1 3.0 0.00 1.0e+00 FES PSRC1 SLC22A3
Breast cancer (self-reported) 2.78 1 0 0.0 0.00 1.0e+00 CDKN2B
Asthma (self-reported) 1.29 1 0 0.0 0.00 1.0e+00 FES
Medication: Aspirin 18.11 6 5 15.2 0.99 5.1e-05 CDKN2B CDKN2B-AS1 FES PSRC1 RP11-288H12.3 SLC22A3
Illnesses of father: None of the above (group 1) 12.12 4 2 6.1 -0.99 5.3e-03 CDKN2B CDKN2B-AS1 FES SLC22A3
Whole body water mass 1.32 3 0 0.0 0.00 1.0e+00 FES PSRC1 SLC22A3
Leg predicted mass (right) 1.54 3 0 0.0 0.00 1.0e+00 FES PSRC1 SLC22A3
Arm fat mass (left) 1.49 2 0 0.0 0.00 1.0e+00 RP1-257A7.5 SLC22A3
Number of self-reported non-cancer illnesses 3.15 1 0 0.0 0.00 1.0e+00 PSRC1
Average weekly champagne plus white wine intake 1.56 1 0 0.0 0.00 1.0e+00 RP11-288H12.3
Eye problems/disorders: Glaucoma 10.30 2 2 6.1 0.00 1.0e+00 CDKN2B CDKN2B-AS1
Medication: Blood pressure 6.34 2 1 3.0 0.00 1.0e+00 FES SLC22A3
Supplements: Fish oil (including cod liver oil) 2.93 1 0 0.0 0.00 1.0e+00 SLC22A3
High cholesterol (Self-reported) 31.19 5 3 9.1 0.80 1.1e-01 FES PSRC1 RP11-288H12.3 RP11-378J18.8 SLC22A3
Medication: Bendroflumethiazide 3.29 1 1 3.0 0.00 1.0e+00 FES
Medication: Paracetamol 1.85 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Medication: Lisinopril 2.31 1 0 0.0 0.00 1.0e+00 FES
Medication: Atorvastatin 20.76 5 2 6.1 0.99 1.5e-03 CDKN2B CDKN2B-AS1 PSRC1 RP11-288H12.3 SLC22A3
Illnesses of father: High blood pressure 5.78 1 1 3.0 0.00 1.0e+00 FES
Ever smoked 2.20 1 0 0.0 0.00 1.0e+00 FES
Basal metabolic rate 1.34 3 0 0.0 0.00 1.0e+00 FES PSRC1 SLC22A3
Leg fat percentage (left) 1.26 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Arm fat-free mass (left) 1.10 2 0 0.0 0.00 1.0e+00 PSRC1 SLC22A3
Risk taking 2.71 1 0 0.0 0.00 1.0e+00 FES
Age started oral contraceptive pill 1.27 1 0 0.0 0.00 1.0e+00 FES
Diastolic blood pressure, automated reading 6.05 3 1 3.0 0.00 1.0e+00 CDKN2B CDKN2B-AS1 FES
Vascular/heart problems diagnosed by doctor 9.18 3 1 3.0 0.00 1.0e+00 CDKN2B FES SLC22A3
Cholesterol lowering medication 16.63 4 2 6.1 0.95 4.7e-02 CDKN2B PSRC1 RP11-288H12.3 SLC22A3
Pain experienced in last month 1.84 1 0 0.0 0.00 1.0e+00 RP1-257A7.5
Basal cell carcinoma (self-reported) 3.26 1 0 0.0 0.00 1.0e+00 CDKN2B
Heart attack/myocardial infarction (self-reported) 35.76 8 8 24.2 1.00 6.5e-13 CDKN2B CDKN2B-AS1 FES PSRC1 RP11-288H12.3 RP11-378J18.8 RP1-257A7.5 SLC22A3
Heart disease (siblings) 12.20 6 0 0.0 0.96 1.8e-03 CDKN2B CDKN2B-AS1 FES RP11-378J18.8 RP1-257A7.5 SLC22A3
Impedance of whole body 0.98 1 0 0.0 0.00 1.0e+00 PSRC1
Leg fat mass (left) 1.16 2 0 0.0 0.00 1.0e+00 RP1-257A7.5 SLC22A3
Arm predicted mass (left) 1.20 2 0 0.0 0.00 1.0e+00 PSRC1 SLC22A3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.33
GTEx Adipose Visceral Omentum 0 0.0000 1.27
GTEx Adrenal Gland 0 0.0000 1.31
GTEx Artery Aorta 3 0.1008 1.39
GTEx Artery Coronary 1 0.0845 1.38
GTEx Artery Tibial 4 0.1064 1.41
GTEx Brain Caudate basal ganglia 0 0.0000 1.26
GTEx Brain Cerebellar Hemisphere 2 0.1343 1.30
GTEx Brain Cerebellum 1 0.0505 1.38
GTEx Brain Cortex 0 0.0000 1.24
GTEx Brain Frontal Cortex BA9 0 0.0000 1.28
GTEx Brain Hippocampus 0 0.0000 1.15
GTEx Brain Hypothalamus 1 0.1695 1.30
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.21
GTEx Brain Putamen basal ganglia 0 0.0000 1.33
GTEx Breast Mammary Tissue 1 0.0507 1.30
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.28
GTEx Breast Mammary Tissue (Female) 1 0.0608 1.23
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.24
GTEx Cells Transformed fibroblasts 3 0.0714 1.31
GTEx Colon Sigmoid 1 0.0684 1.30
GTEx Colon Transverse 0 0.0000 1.26
GTEx Esophagus Gastroesophageal Junction 1 0.0692 1.28
GTEx Esophagus Mucosa 1 0.0301 1.27
GTEx Esophagus Muscularis 2 0.0619 1.30
GTEx Heart Atrial Appendage 0 0.0000 1.33
GTEx Heart Left Ventricle 0 0.0000 1.26
GTEx Liver 1 0.1395 1.28
GTEx Lung 1 0.0348 1.35
GTEx Muscle Skeletal 1 0.0346 1.29
GTEx Nerve Tibial 2 0.0463 1.31
GTEx Ovary 1 0.1101 1.26
GTEx Pancreas 0 0.0000 1.28
GTEx Pituitary 0 0.0000 1.29
GTEx Prostate 1 0.1198 1.26
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.32
GTEx Skin Sun Exposed Lower leg 2 0.0549 1.33
GTEx Small Intestine Terminal Ileum 0 0.0000 1.27
GTEx Spleen 0 0.0000 1.40
GTEx Stomach 0 0.0000 1.36
GTEx Testis 0 0.0000 1.22
GTEx Thyroid 0 0.0000 1.34
GTEx Uterus 0 0.0000 1.29
GTEx Vagina 0 0.0000 1.36
GTEx Whole Blood 1 0.0502 1.28
METSIM Adipose 0 0.0000 1.28
NTR Blood 0 0.0000 1.29
ROSMAP Brain Pre-frontal Cortex 1 0.0228 1.27
YFS Blood 0 0.0000 1.21
CommonMind Brain Pre-frontal Cortex 4 0.0744 1.31
TCGA Breast Tumor 0 0.0000 1.17
TCGA Breast Normal 0 0.0000 1.19
TCGA Ovarian Tumor 1 0.0342 1.18
TCGA Prostate Tumor 0 0.0000 1.20