Hub : Genes

TMEM106B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.1660 0.0550 5.3e-04 0.004 NA 0.043 NA 0.012 1.6e-01 NA 3.3e-04 NA 3.9e-02
2 GTEx Esophagus Mucosa 0.1180 0.0420 1.0e-03 -0.001 NA -0.004 NA -0.001 3.7e-01 NA 9.8e-01 NA 4.2e-01
3 GTEx Whole Blood 0.1010 0.0350 1.4e-04 0.004 NA 0.010 NA 0.027 1.1e-01 NA 3.9e-02 NA 1.6e-03
4 YFS Blood 0.0776 0.0171 1.3e-13 0.055 0.050 0.051 0.052 0.055 1.8e-17 7.2e-16 2.6e-16 1.2e-16 1.6e-17
5 TCGA Cervical Squamous Cell Carcinoma 0.1720 0.0770 1.9e-03 0.020 0.089 0.068 NA 0.042 3.4e-02 3.7e-05 3.1e-04 NA 3.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.0 1.5 3.3 -0.8 1.5 -1.8 1.2 0.1
Bipolar Disorder or Schizophrenia 0.7 1.8 3.7 -1.5 0.1 -1.6 1.9 0.7
Depressed Affect (Nagel 2018) 6.6 13.9 41.3 -3.4 0.1 2.9 6.4 -2.9
Depression (Nagel 2018) 6.6 10.0 28.0 -3.8 0.1 2.7 5.3 0.0
Intelligence (Savage-Jansen 2018) 1.1 3.4 9.1 -1.2 0.2 -3.0 1.2 -2.2
Neuroticism (Nagel 2018) 4.3 10.1 31.6 -2.6 0.3 1.0 5.6 -3.3
Schizophrenia (2018) 0.5 1.0 2.1 -1.1 -1.1 -0.5 1.5 0.6
Schizophrenia vs Biploar Disorder 0.7 1.0 2.1 -0.2 -1.3 1.5 -0.9 0.3
Worry (Nagel 2018) 3.2 6.7 25.2 -1.3 1.1 1.0 5.0 -2.1
Alzheimer’s Disease (in mother) 3.3 3.9 8.6 2.8 0.0 -1.7 -2.9 0.1
Alzheimer’s Disease (in father) 0.1 0.1 0.3 0.3 -0.4 0.3 0.5 -0.1
Alzheimer’s Disease (including proxy) 2.9 4.2 10.3 3.2 -1.0 -1.3 -2.9 -0.4
Crohns Disease (2017) 0.4 0.9 1.7 -1.0 1.3 -0.2 1.3 0.3
Irritable Bowel Disease (IBD) 0.2 0.6 2.4 0.0 1.6 0.1 0.5 0.5
Ulcerative Colitis (UC) 0.2 0.4 1.1 0.4 1.0 0.5 0.1 0.6
Major Depression (MDD) 4.8 5.8 18.3 -1.9 -0.8 2.4 4.3 -0.5
Reaction Time 2.3 4.3 10.9 0.5 -1.3 3.3 2.2 -1.9
Verbal and Numeric Reasoning (VNR) 1.1 2.7 8.1 -0.6 0.5 -2.8 0.8 -2.1
Breast Cancer 0.4 0.9 2.3 1.2 1.5 0.8 0.2 0.0
Ovarian Cancer 1.2 1.6 4.3 -2.1 1.6 1.1 0.2 0.3
Prostate Cancer 2.5 3.6 7.7 2.8 1.0 -1.3 0.7 -2.6
Age at First Birth 0.8 1.1 2.8 0.9 0.2 1.7 -0.3 -1.4
Bipolar Disorder (2011) 1.0 1.0 2.3 0.1 0.4 -1.3 1.5 -0.8
Body Mass Index (BMI) (2010) 0.3 0.4 1.0 -0.3 -1.0 0.1 0.7 -0.6
Coronary Artery Disease (CAD) 2.0 2.4 6.9 -2.1 0.1 0.1 2.6 0.9
Crohns Disease (2012) 0.1 0.1 0.5 -0.7 -0.4 -0.2 -0.1 -0.0
Mean Putamen Volume 0.9 1.1 3.4 0.7 1.0 -0.5 -1.9 -0.5
Fasting Glucose 0.9 1.1 2.0 1.0 -0.8 -1.4 0.6 -1.2
HbA1C 0.8 0.9 2.1 -0.7 -1.0 -0.6 0.7 -1.5
HDL Cholesterol 0.4 0.7 1.6 -0.0 -0.5 -0.9 -0.9 1.2
LDL Cholesterol 1.3 2.1 7.1 -0.3 -2.7 0.5 1.3 -1.2
Lupus 0.7 1.0 4.6 0.3 -0.4 -2.1 -0.2 0.6
Neuroticism (2016) 0.6 0.8 2.3 -0.5 -1.1 -0.3 1.5 -0.5
Primary Biliary Cirrhosis 0.5 0.7 1.8 0.9 -1.3 0.4 -0.8 0.2
Rheumatoid Arthritis 0.6 0.8 3.4 -0.1 -0.6 0.1 1.8 0.6
Schizophrenia (2014) 0.3 0.7 1.7 -0.6 -1.3 0.2 0.8 0.8
Triglycerides 0.5 0.9 2.2 0.3 -0.3 1.5 1.4 0.3
Type 2 Diabetes (T2D) (2012) 0.1 0.2 0.4 0.4 -0.6 0.2 0.1 -0.4
Ulcerative Colitis 0.3 0.4 1.4 0.2 -0.6 0.3 1.2 -0.2
Blood Eosinophil Count 0.2 1.7 5.0 -0.2 2.2 -1.5 -0.9 0.4
Blood Platelet Count 0.0 0.5 1.1 -0.3 -0.5 -0.1 1.1 -1.1
Blood Red Count 0.3 3.3 8.9 -3.0 0.2 1.0 2.6 -0.0
Blood White Count 0.1 1.0 1.5 0.2 1.1 -1.1 -1.1 1.2
Heel T-Score 0.4 3.2 9.9 -2.1 0.6 0.7 3.1 0.8
BMI 1.3 7.5 14.6 -3.6 0.5 3.1 3.8 -0.2
Height 0.7 13.0 43.4 -0.8 -2.1 -3.8 -6.6 1.2
Waist Hip Ratio (WHR) 0.3 1.4 4.5 -0.7 -0.7 -0.6 2.1 -1.0
Systolic Blood Pressure 0.4 2.1 9.5 -0.0 0.4 0.5 -0.8 -3.1
Smoking Status 0.8 1.9 2.9 -1.1 1.5 0.2 1.7 1.7
Allergy or Eczema 0.6 1.7 7.7 -0.3 -0.3 -0.5 2.8 -0.5
Cardiovascular Disease 1.5 4.9 12.7 -1.5 0.6 2.2 3.6 -2.1
Hypothyroidism (self reported) 1.0 2.2 7.7 -0.3 -0.2 2.8 1.7 -0.6
Respiratory disease 1.1 2.4 7.5 0.3 -1.7 0.1 2.7 -1.1
Type 2 Diabetes (T2D) (2018) 1.3 2.3 4.6 -1.6 -1.2 1.8 2.1 -0.1
Lung FEV1/FVC ratio 0.2 0.8 2.7 -1.6 1.0 -0.0 0.2 -0.5
Lung FVC 0.3 1.6 4.0 0.8 -0.6 -1.7 -2.0 -0.2
Neuroticism 3.6 8.6 28.3 -2.1 0.8 1.2 5.3 -2.9
Chronotype (morning person) 1.6 3.7 10.7 -1.6 -1.1 3.3 1.6 -1.3
Hair Pigment 0.0 1.3 3.4 -1.2 -1.8 0.2 0.6 1.2
Tanning 0.2 2.9 6.5 1.7 0.2 -2.5 -1.5 -1.6
Hand grip strength (left) 0.4 1.0 3.4 -0.7 -1.9 -0.5 -0.7 0.2
Number of treatments/medications taken 1.5 2.7 8.0 -1.5 1.1 1.3 2.8 -0.6
Average weekly spirits intake 0.1 0.1 0.2 0.3 0.5 -0.1 0.2 -0.1
Sensitivity / hurt feelings 1.0 1.7 4.9 0.3 -0.8 -2.2 1.6 -0.6
Frequency of depressed mood in last 2 weeks 5.9 8.3 26.0 -3.4 -0.3 1.9 5.1 -0.2
Hearing difficulty/problems: Yes 0.4 0.7 1.2 -1.1 0.8 0.5 1.1 -0.4
Relative age of first facial hair 0.3 0.7 1.7 0.9 1.0 -0.1 1.3 0.1
Other serious medical condition/disability diagnosed by doctor 2.2 2.8 6.4 -0.9 1.4 1.7 2.5 1.3
Ever used hormone-replacement therapy (HRT) 1.5 1.9 5.2 -0.1 2.3 0.0 1.7 1.2
Ever had hysterectomy (womb removed) 1.3 1.5 3.1 -1.3 -0.1 1.5 1.8 0.6
Systolic blood pressure, automated reading 0.4 1.2 2.9 0.8 0.2 -0.4 -1.4 -1.7
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.2 0.1 0.0 -0.2 0.1 -0.4
Angina 3.0 3.9 8.8 0.1 -0.7 2.9 3.0 -1.3
Medication for hormone replacement therapy 3.4 3.8 11.8 -0.5 0.5 -0.5 2.5 3.4
Vitamin and mineral supplements 2.5 3.5 7.0 -1.4 0.8 2.6 1.3 -2.4
Supplements: Zinc 0.5 0.6 2.1 0.1 -1.5 0.6 0.1 -0.5
Medication: Co-codamol 1.2 1.4 5.2 2.3 0.7 0.8 0.6 -0.1
Medication: Metformin 1.8 2.6 8.9 -0.8 -0.3 1.8 3.0 -0.1
Diabetes (father) 1.8 2.3 4.8 1.2 -2.2 -1.2 -1.9 0.5
Diabetes (mother) 1.7 2.2 7.3 -1.0 1.3 2.7 0.6 -0.6
Severe depression (siblings) 1.8 2.0 5.4 -1.5 -0.5 1.4 2.3 -0.1
Pack years adult smoking proportion 0.6 1.0 2.0 -1.4 0.5 1.4 0.8 -0.3
Impedance of leg (right) 0.7 3.3 9.6 1.7 -0.9 -1.5 -3.1 0.9
Leg fat-free mass (left) 0.4 2.3 9.3 -3.0 0.8 0.9 0.9 -0.0
Trunk fat percentage 0.5 2.0 6.0 -2.4 1.4 1.2 0.7 -0.3
Hand grip strength (right) 0.2 0.6 1.7 -0.9 -1.3 -0.5 -0.2 -0.2
Townsend deprivation index at recruitment 0.7 1.0 2.7 -1.6 0.4 1.4 0.6 -0.1
Current tobacco smoking 0.6 1.0 1.6 -1.0 0.1 1.0 1.1 1.3
Average weekly fortified wine intake 0.4 0.5 1.2 -0.7 0.3 -0.8 0.3 1.1
Maternal smoking around birth 0.5 0.7 1.7 1.3 0.7 -0.4 0.2 -1.1
Fed-up feelings 1.9 3.5 7.0 -2.5 1.2 0.5 2.6 -1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 4.0 5.3 14.3 -3.0 -0.3 1.5 3.8 0.9
Relative age voice broke 1.0 1.5 3.5 0.3 -0.8 -1.7 -0.5 1.9
Taking other prescription medications 2.2 3.4 11.7 -2.0 0.8 0.8 3.4 -0.5
Age when periods started (menarche) 0.5 1.3 3.4 1.2 -0.8 -0.7 -0.5 1.8
Bilateral oophorectomy (both ovaries removed) 1.5 1.7 5.0 -0.6 -0.3 1.7 2.2 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.3 -0.5 0.4 -1.1 1.1 0.4
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.2 -0.1 -1.1 -0.3 0.0 -0.9
Qualifications: CSEs or equivalent 0.7 0.9 3.3 -0.6 -0.7 1.8 -0.5 -0.0
Serious illness, injury or assault to yourself 1.3 1.6 3.0 -1.2 1.2 1.7 1.4 -0.2
High blood pressure 1.1 3.1 7.8 -1.3 0.2 1.5 2.8 -1.8
Hayfever, allergic rhinitis or eczema 0.7 1.6 6.9 -0.8 -0.5 -0.3 2.6 -0.2
Multivitamins +/- minerals 2.4 3.0 5.7 1.7 -1.4 -2.4 -1.4 1.6
Stomach or abdominal pain in last month 0.8 1.0 2.2 -1.5 -1.5 -0.7 0.6 0.2
Supplements: Glucosamine 2.1 2.7 7.8 1.3 -0.1 -1.5 -2.8 1.3
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 1.3 0.4 0.1 -1.1 0.1 0.2
Medication: Atenolol 1.9 2.4 3.7 -1.7 1.8 1.2 1.9 -0.7
Medication: Levothyroxine sodium 0.6 1.0 1.6 -1.1 0.8 1.2 1.3 -0.2
Sitting height 0.6 4.3 19.5 -4.4 -0.6 0.3 0.8 0.8
Chronic bronchitis/emphysema (father) 0.9 1.1 2.3 -1.5 0.1 1.2 1.2 0.5
High blood pressure (mother) 1.8 2.5 9.9 -0.3 0.0 3.1 1.6 0.4
Body mass index (BMI) 1.8 7.7 14.1 -3.3 1.6 3.1 3.8 -1.3
Impedance of leg (left) 0.8 3.7 10.1 1.5 -1.6 -1.6 -3.2 1.1
Leg predicted mass (left) 0.5 2.4 9.4 -3.1 0.9 0.9 1.0 -0.1
Trunk fat mass 0.7 2.9 10.1 -3.2 1.1 1.5 0.9 -0.2
Waist circumference 1.5 5.4 12.7 -3.6 1.0 2.4 2.5 -1.2
Number of incorrect matches in round 0.7 1.2 2.2 1.1 0.8 -0.3 -1.3 1.5
Past tobacco smoking 0.5 0.9 2.1 0.9 -0.7 0.7 -1.4 -0.8
Alcohol usually taken with meals 0.6 1.0 3.9 0.9 -0.5 -2.0 0.4 0.1
Nervous feelings 0.7 1.4 5.0 -0.5 -0.2 -0.8 2.2 -0.9
Frequency of tenseness / restlessness in last 2 weeks 5.4 8.4 24.4 -3.7 0.7 1.6 4.9 0.7
Hearing difficulty/problems with background noise 0.7 1.1 2.4 -1.5 0.2 0.9 1.5 0.1
Hair/balding pattern: Pattern 2 0.4 0.5 1.7 -1.3 0.2 0.7 0.5 0.1
Had menopause 0.2 0.2 1.0 -0.0 1.0 0.3 -0.1 0.0
Had other major operations 0.7 0.8 2.1 1.1 -0.6 1.4 -0.6 0.2
Forced vital capacity (FVC) 0.6 2.3 5.5 -0.3 -0.7 -2.3 -2.3 0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.8 -0.6 0.2 -1.2 1.4 0.2
Ever unenthusiastic/disinterested for a whole week 2.0 2.5 4.0 -1.8 1.1 1.1 2.0 -1.7
Qualifications: None of the above 0.3 0.7 1.6 0.6 0.7 1.3 0.9 0.1
Financial difficulties in last 2 years 6.2 8.3 19.7 -4.4 0.8 2.4 3.9 0.1
Mouth/teeth dental problems 0.3 0.5 1.5 0.6 0.6 -0.2 -1.2 0.3
Heart attack 2.9 3.7 7.8 -2.6 1.2 1.4 2.8 -0.7
Allergy 0.9 2.0 8.2 0.3 1.1 -0.2 -2.9 0.6
Pain all over the body in last month 6.5 7.0 10.1 -2.9 2.5 2.7 3.2 1.6
Diabetes (self-reported) 1.3 2.1 6.2 -0.6 -0.6 1.7 2.5 -0.7
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.6 0.6 0.2 -1.3 -0.0 -0.5
Medication: Ramipril 1.0 1.2 2.0 -1.2 -0.1 -1.2 1.4 -1.2
Medication: Simvastatin 0.4 0.5 1.6 0.1 0.8 -0.1 1.3 0.7
Fluid intelligence score 1.1 2.2 6.1 -0.7 0.2 -2.5 -1.3 -1.7
Illnesses of siblings 2.7 3.8 9.0 1.2 -1.4 -2.5 -3.0 0.1
Neuroticism score 4.8 9.9 36.7 -2.5 0.3 1.8 6.1 -1.8
Weight 0.8 3.8 13.1 -3.6 0.7 1.7 1.4 -0.5
Impedance of arm (right) 1.5 6.8 18.7 2.9 -0.5 -2.5 -4.3 0.4
Arm fat percentage (right) 0.8 3.0 6.4 -2.5 1.5 1.9 1.5 -0.9
Trunk fat-free mass 0.3 1.8 8.5 -2.9 -0.5 0.6 0.3 0.3
Hip circumference 0.6 2.7 8.1 -2.8 1.1 1.7 0.9 -0.6
Time employed in main current job 1.4 1.6 3.2 1.8 0.5 -1.5 -1.6 -0.2
Alcohol intake versus 10 years previously 2.7 4.1 11.5 -1.7 1.0 1.6 3.4 -1.5
Father’s age at death 1.3 1.8 6.5 0.5 -0.4 -1.1 -2.5 0.9
Worrier / anxious feelings 2.0 3.8 13.7 -1.7 0.9 -0.3 3.7 -1.2
Frequency of tiredness / lethargy in last 2 weeks 3.4 5.5 15.6 -2.9 0.1 1.5 4.0 -0.9
Falls in the last year 0.9 1.2 3.1 1.5 0.4 -1.8 -0.7 0.3
Hair/balding pattern: Pattern 3 1.2 1.8 5.1 2.3 1.0 -1.2 -0.2 -1.3
Number of live births 0.2 0.3 0.5 0.7 0.4 -0.5 -0.1 0.6
Forced expiratory volume in 1-second (FEV1) 0.6 2.0 5.6 -0.4 -0.7 -1.9 -2.4 -0.1
Pulse rate 0.7 1.1 2.6 -1.6 0.1 0.8 1.3 -0.8
Happiness 1.2 1.5 3.3 -1.5 0.4 0.7 1.8 -1.1
Noisy workplace 0.3 0.3 1.1 0.6 0.3 -1.0 0.3 0.3
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.5 0.9 -1.1 -1.2 0.1 -1.0
Serious illness, injury or assault of a close relative in last 2 years 1.7 2.0 4.0 -1.8 0.4 1.6 2.0 0.1
Mouth/teeth dental problems: Dentures 0.8 1.4 4.4 0.6 -1.1 -0.7 -0.9 -2.1
Asthma 0.8 1.6 3.2 0.7 -1.4 0.2 1.8 -1.5
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.1 -1.1 -0.5 1.1 -0.4 -0.8
Medication: Cholesterol lowering 1.4 2.2 5.4 -1.6 0.5 1.5 2.3 -0.9
Depression (self-reported) 6.8 8.2 23.4 -3.4 1.9 0.9 4.8 1.2
Medication: Lansoprazole 1.6 1.8 5.1 -1.1 0.0 1.6 2.3 -0.1
Prospective memory result 0.1 0.1 0.3 0.5 -0.4 0.5 0.2 -0.1
Lung cancer (father) 0.6 0.7 2.2 -1.5 0.3 1.0 -0.1 0.2
Illnesses of mother 2.6 3.2 6.2 0.6 1.9 -2.5 -1.2 2.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.9 8.4 -0.1 -0.8 -2.3 -2.9 -0.1
Pulse wave Arterial Stiffness index 1.8 2.1 4.2 -2.1 1.4 -0.2 1.9 0.8
Impedance of arm (left) 1.3 6.0 15.6 2.4 -0.3 -2.8 -4.0 0.8
Arm fat mass (right) 1.0 4.1 9.9 -3.1 1.0 2.2 2.0 -0.9
Trunk predicted mass 0.3 2.0 9.2 -3.0 -0.4 0.6 0.3 0.3
Standing height 0.7 7.4 23.6 -0.8 -1.8 -2.8 -4.9 1.4
Length of working week for main job 0.9 1.0 2.0 -0.3 -0.8 1.1 1.4 -0.9
Exposure to tobacco smoke at home 0.9 1.0 2.1 1.5 -0.8 -1.0 -0.6 -1.0
Breastfed as a baby 0.6 0.8 1.3 -0.6 -0.9 1.1 0.9 -0.9
Tense / ‘highly strung’ 3.8 6.3 27.9 -0.9 0.4 1.5 5.3 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 9.7 14.8 40.0 -3.6 2.0 4.0 6.3 -0.4
Hair/balding pattern: Pattern 4 0.6 1.4 5.4 -1.0 0.6 0.6 0.4 2.3
Birth weight of first child 1.1 2.0 3.8 -1.6 1.9 1.5 1.3 0.2
Peak expiratory flow (PEF) 0.5 1.1 2.2 -1.0 -1.5 -0.6 -1.4 0.1
Pulse wave reflection index 1.6 2.0 4.1 -1.7 1.4 0.4 2.0 0.8
Ever highly irritable/argumentative for 2 days 1.0 1.2 2.5 -1.6 1.1 0.3 1.4 -0.4
Loud music exposure frequency 0.4 0.4 0.9 -0.2 0.7 0.2 0.8 0.9
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 3.1 -1.0 -1.0 -0.4 1.0 -1.8
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 6.4 -0.8 -0.1 -0.4 2.5 -0.8
Blood clot in the leg (DVT) 0.4 0.6 2.2 0.4 -0.2 0.5 -0.5 -1.5
Medication: Paracetamol 1.2 1.9 3.2 -1.3 0.7 1.1 1.7 -1.8
Headache pain in last month 0.7 1.1 2.5 -1.4 -0.9 0.6 1.6 -0.0
Medication for cholesterol, blood pressure or diabetes 1.5 2.5 5.8 1.8 -0.7 -0.8 -2.4 1.6
Glaucoma (self-reported) 1.4 1.7 4.9 -1.3 -0.0 1.3 2.2 0.3
Gout (self-reported) 0.8 1.1 3.7 0.9 1.9 0.4 0.2 1.0
Hypothyroidism/myxoedema (self-reported) 0.9 1.8 3.8 -0.6 0.9 2.0 1.9 0.7
Medication: Amlodipine 0.7 1.0 2.7 -1.1 0.6 1.6 0.7 -0.3
Medication: Ventolin 100micrograms inhaler 0.8 1.1 2.7 1.6 -0.4 -1.4 0.2 0.6
Birth weight 0.5 1.1 2.5 -1.3 -0.4 1.6 0.8 -0.7
Chronic bronchitis/emphysema (mother) 1.3 1.6 2.4 1.3 -1.3 -1.6 -0.6 -1.3
High blood pressure (siblings) 3.9 5.6 15.6 -1.7 1.8 2.5 4.0 -0.1
Forced vital capacity (FVC), Best measure 1.2 4.3 10.4 0.0 -0.8 -3.2 -3.1 0.8
Body fat percentage 0.7 2.7 7.6 -2.7 1.3 1.6 1.3 -0.4
Leg fat percentage (right) 1.1 3.9 7.7 -2.8 1.5 2.2 2.1 -0.5
Arm fat-free mass (right) 0.6 3.0 11.5 -3.4 -0.2 1.1 1.4 0.2
Exposure to tobacco smoke outside home 1.2 1.6 3.5 0.9 1.1 1.1 1.9 -1.1
Comparative body size at age 10 0.3 0.9 2.5 0.3 -0.4 1.6 0.6 -1.2
Number of full brothers 1.5 1.9 5.0 -1.2 1.0 1.4 2.2 0.4
Worry too long after embarrassment 0.8 1.3 3.0 -0.2 -0.2 -1.7 0.8 -1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 6.4 8.3 21.4 -3.6 0.8 2.5 4.6 -0.2
Wheeze or whistling in the chest in last year 1.0 1.7 5.2 -0.9 0.4 1.4 2.3 0.8
Number of children fathered 1.6 1.8 5.1 2.3 1.4 -0.3 -0.1 1.4
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.7 5.2 2.3 -0.4 1.5 0.8 0.3
Age at first live birth 0.7 1.3 2.4 1.0 -0.1 -1.5 -0.8 1.6
Pulse wave peak to peak time 1.8 2.2 4.8 2.0 -1.3 0.2 -2.2 -0.6
Health satisfaction 1.0 1.3 3.5 -1.1 0.7 0.8 1.9 0.8
Shortness of breath walking on level ground 1.7 2.0 6.1 -0.9 0.5 1.7 2.5 -0.0
Qualifications: College or University degree 0.5 1.5 6.7 -0.1 0.5 -2.6 -0.1 0.7
Eye problems/disorders: None of the above 0.1 0.1 0.3 -0.5 -0.2 -0.0 0.2 -0.5
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.9 -0.5 -0.9 -0.6 -0.5 0.4
Emphysema/chronic bronchitis 1.6 1.8 5.6 0.5 -1.4 1.0 2.4 -0.2
Medication for pain relief, constipation, heartburn 1.8 3.0 4.7 2.0 0.2 -2.2 -2.2 1.3
Neck or shoulder pain in last month 1.5 2.1 5.1 -0.9 0.1 2.3 1.6 -1.3
Medication: Blood pressure 1.0 1.8 5.5 -0.9 0.3 0.9 1.4 -2.3
Angina (self-reported) 3.8 4.9 11.7 0.1 -0.9 3.0 3.4 -1.7
Migraine (self-reported) 0.7 0.8 1.8 -0.9 -0.6 -1.3 -0.5 -1.0
Medication: Ibuprofen 0.4 0.4 1.5 -0.6 0.1 1.2 -0.1 -0.5
Medication: Allopurinol 0.9 1.2 2.2 -1.5 1.0 0.3 1.0 1.4
Medication: Omeprazole 0.8 1.0 1.9 -0.4 -1.2 -0.3 1.1 -1.4
Medication: Seretide 50 evohaler 0.9 1.0 2.1 1.5 -0.8 -1.2 0.1 0.8
Mean time to correctly identify matches 1.4 2.7 6.1 0.8 -1.5 1.9 1.0 -2.5
Heart disease (mother) 3.0 3.7 9.6 -1.6 -1.2 3.1 2.0 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 1.8 -1.3 -0.9 0.4 0.9 1.4
Whole body fat mass 0.8 3.4 11.4 -3.4 0.9 1.6 1.4 -0.4
Leg fat mass (right) 1.2 4.8 12.4 -3.5 1.5 2.2 2.1 -0.5
Arm predicted mass (right) 0.6 3.0 12.5 -3.5 -0.1 1.1 1.2 0.1
Pulse rate, automated reading 0.2 0.7 1.9 -1.4 -0.4 0.4 0.1 -1.1
Alcohol intake frequency. 2.2 5.1 9.9 -2.7 0.1 3.1 2.1 -1.9
Comparative height size at age 10 0.6 3.5 12.8 0.0 -1.4 -1.5 -3.6 -0.7
Number of full sisters 1.2 1.4 3.0 -1.7 -0.7 0.8 1.7 0.5
Suffer from ‘nerves’ 2.4 3.7 13.4 -1.1 1.4 1.3 3.7 -0.4
Overall health rating 3.0 6.4 9.7 -2.9 2.1 3.1 3.1 -0.6
Chest pain or discomfort 1.8 2.6 5.7 -1.1 0.7 2.4 2.4 -0.1
Had major operations 0.7 0.8 1.9 1.4 0.0 -0.4 -1.3 -0.3
Age at last live birth 0.8 1.2 1.8 1.3 -0.5 -1.3 -1.0 1.1
Family relationship satisfaction 3.5 4.3 13.2 -3.6 -0.0 0.6 2.8 0.2
Leg pain on walking 1.3 1.7 3.2 -1.8 1.8 0.3 1.3 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.6 -0.4 -0.2 -0.1 -0.8 -0.5
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.2 0.2 0.5 -0.3 -0.4 -0.3
Illness, injury, bereavement, stress in last 2 years 2.6 3.2 8.6 2.2 -0.2 -1.5 -2.9 -0.3
Medication: Aspirin 2.2 2.9 10.9 -1.0 0.0 0.8 3.3 -1.4
Supplements: Vitamin C 2.0 2.4 4.8 1.2 1.0 -2.2 -0.1 2.2
Knee pain experienced in last month 1.0 1.6 4.5 -2.1 0.3 -1.2 0.4 1.2
Hypertension (Self-reported) 0.9 2.5 6.1 -0.9 -0.0 1.4 2.5 -2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.8 -0.9 0.3 -0.3 1.3 -0.0
Illnesses of father: Heart disease 1.0 1.4 3.7 -0.5 1.6 0.2 1.9 -0.7
Illnesses of siblings: Diabetes 0.1 0.2 0.4 0.3 -0.0 0.7 0.4 0.5
Smoking status: Previous 0.5 0.8 1.3 -1.1 0.9 -0.4 1.0 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 2.2 -0.9 0.5 -0.7 -1.5 0.6
Whole body fat-free mass 0.4 2.3 10.3 -3.2 -0.1 0.8 0.6 0.1
Leg fat-free mass (right) 0.4 2.1 8.9 -3.0 0.5 0.7 0.8 -0.1
Arm fat percentage (left) 0.9 3.7 7.9 -2.8 1.8 1.9 1.9 -0.5
Average weekly red wine intake 1.5 2.2 4.7 1.8 -2.2 -1.1 -1.1 0.5
Handedness (chirality/laterality): Left-handed 0.7 0.9 2.0 -0.9 1.1 0.5 1.4 0.3
Mood swings 5.9 10.7 36.6 -2.0 -1.2 2.7 6.0 -2.1
Loneliness, isolation 6.7 9.3 23.4 -3.8 -0.1 2.8 4.8 -0.7
Long-standing illness, disability or infirmity 3.2 4.8 15.0 -0.7 2.3 1.8 3.9 0.2
Ever had bowel cancer screening 1.6 1.9 4.3 -0.3 1.6 -0.0 2.1 1.6
Diabetes diagnosed by doctor 1.6 2.7 8.9 -0.9 -0.5 1.8 3.0 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 2.2 -0.0 0.1 1.5 1.5 0.2
Friendships satisfaction 3.3 4.1 8.6 -2.9 -0.8 2.1 2.6 0.4
Qualifications: nursing, teaching 0.6 0.9 2.8 -0.9 0.4 -0.5 0.8 1.7
Commuting to job workplace: Walk 0.5 0.5 1.3 -1.1 0.3 0.0 1.1 -0.1
Eye problems/disorders: Cataract 0.3 0.3 0.8 0.6 0.5 -0.9 0.2 -0.2
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 2.2 -0.9 -0.0 -0.5 0.5 1.5
Medication for cholesterol 1.7 2.6 8.8 0.6 0.1 -0.7 -3.0 -1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.9 -1.1 -0.2 1.1 0.9 1.7
Back pain experienced in last month 0.2 0.3 1.4 -0.1 0.1 1.2 -0.1 -0.2
Mineral and other dietary supplements 2.5 3.3 6.6 -1.5 -0.8 1.9 2.6 -1.9
Breast cancer (self-reported) 0.4 0.5 2.1 0.7 -0.1 1.4 0.2 -0.2
Asthma (self-reported) 0.8 1.5 3.0 0.8 -1.5 0.5 1.7 -1.3
Osteoporosis (self-reported) 0.6 0.7 1.9 -0.2 -0.9 1.4 -0.4 0.7
Osteoarthritis (self-reported) 0.7 0.9 2.9 -1.3 -0.3 1.7 0.2 -0.2
Medication: Aspirin 2.1 2.7 10.4 -0.4 -0.0 0.4 3.2 -1.6
Medication: Gliclazide 1.1 1.2 2.5 1.6 -0.9 0.6 0.7 -1.4
Illnesses of father: None of the above (group 1) 0.3 0.4 0.7 -0.7 -0.5 -0.8 -0.7 0.1
Smoking status: Current 0.5 0.8 2.1 -0.7 0.2 0.5 1.0 1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.7 1.3 -0.2 -0.5 0.4 -0.9
Whole body water mass 0.4 2.1 9.5 -3.1 -0.1 0.8 0.6 0.0
Leg predicted mass (right) 0.4 1.9 8.3 -2.9 0.4 0.6 0.7 -0.1
Arm fat mass (left) 1.0 4.1 11.1 -3.3 1.1 1.9 1.9 -0.8
Number of self-reported non-cancer illnesses 3.6 6.2 20.3 -2.2 -0.4 2.3 4.5 -0.8
Average weekly champagne plus white wine intake 2.4 3.3 6.7 1.2 -1.7 -2.6 -2.3 0.4
Miserableness 5.1 8.8 29.9 -3.1 -0.5 1.8 5.5 -1.1
Guilty feelings 1.6 2.4 7.4 -1.6 0.3 -0.1 2.7 -1.3
Wears glasses or contact lenses 1.5 1.7 4.9 0.8 2.2 -0.8 -1.5 0.6
Ever taken oral contraceptive pill 0.3 0.3 1.1 -0.5 0.3 0.3 -0.1 -1.1
Hearing aid user 0.2 0.3 0.7 -0.8 0.2 -0.5 -0.4 0.5
Mother’s age at death 0.3 0.4 1.3 -0.1 -0.4 0.3 -1.1 -0.6
Financial situation satisfaction 2.7 3.3 8.2 -2.7 0.7 0.0 2.9 0.7
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.5 0.9 1.1 0.6 1.2 0.7
Commuting to job workplace: Public transport 0.5 0.6 1.5 0.9 -0.3 -0.2 0.7 -1.2
Eye problems/disorders: Glaucoma 0.9 1.0 2.4 -0.8 0.7 1.2 1.6 -0.0
Medication: Blood pressure 0.5 0.9 3.4 0.4 0.7 0.2 1.9 -0.3
Pain type(s) experienced in last month: Hip pain 1.2 1.5 4.3 -1.4 -0.3 2.1 1.0 -0.4
Supplements: Fish oil (including cod liver oil) 2.3 3.1 4.2 1.4 2.1 -1.5 -1.9 1.9
High cholesterol (Self-reported) 2.1 3.7 8.8 -2.1 -0.5 2.0 3.0 1.0
Medication: Bendroflumethiazide 0.3 0.5 1.2 0.4 0.4 0.1 1.1 -0.8
Medication: Paracetamol 1.1 1.7 3.0 -1.5 1.1 0.7 1.7 -1.2
Medication: Lisinopril 2.2 2.8 4.5 0.8 1.3 1.9 1.9 -2.1
Medication: Atorvastatin 1.5 1.9 4.9 -1.4 -0.3 1.2 2.2 -1.0
Illnesses of father: High blood pressure 1.0 1.2 4.8 -0.7 -0.0 0.9 2.2 0.3
Alcohol drinker status: Never 0.6 0.7 1.2 0.9 -0.8 0.2 -1.0 -1.1
Ever smoked 0.3 0.6 1.0 -0.7 0.5 -0.7 0.7 1.0
Basal metabolic rate 0.5 2.7 11.8 -3.4 0.1 1.0 0.8 0.1
Leg fat percentage (left) 1.1 3.9 8.8 -3.0 1.0 2.2 2.1 -0.5
Arm fat-free mass (left) 0.6 3.0 11.7 -3.4 -0.4 1.3 1.2 -0.1
Number of operations (self-reported) 0.6 0.9 4.5 0.4 -0.0 2.1 0.1 -0.1
Average weekly beer plus cider intake 0.2 0.3 1.3 0.2 1.2 0.2 -0.1 -0.3
Irritability 5.9 10.0 27.4 -3.7 -0.6 2.4 5.2 -1.6
Risk taking 2.6 3.7 10.4 -2.1 -0.7 1.3 3.2 -1.3
Ever had prostate specific antigen (PSA) test 0.5 0.5 1.4 1.2 0.3 0.2 -0.9 0.6
Fractured/broken bones in last 5 years 1.2 1.5 2.6 1.6 1.2 -1.2 -1.4 0.4
Age started oral contraceptive pill 0.4 0.5 1.8 -0.3 0.3 -1.3 -0.7 -0.0
Diastolic blood pressure, automated reading 0.3 0.8 2.6 0.2 0.9 -0.2 -0.8 -1.6
Ever depressed for a whole week 3.4 4.2 10.6 -2.6 0.6 1.8 3.3 -0.2
Unable to work because of sickness or disability 1.5 1.9 3.6 -0.7 1.3 1.9 1.9 0.5
Commuting to job workplace: Cycle 0.4 0.4 1.1 0.7 -0.2 -0.1 -0.8 1.0
Myopia 1.6 2.3 6.4 -2.5 1.1 0.9 1.2 1.3
Vascular/heart problems diagnosed by doctor 1.6 4.5 10.8 1.5 -0.0 -2.0 -3.3 2.3
Cholesterol lowering medication 0.9 1.4 5.1 -0.5 -0.6 0.6 2.2 1.0
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.4 -0.5 -1.2 0.1 1.1 -1.1
Pain experienced in last month 0.9 1.5 3.3 1.4 -1.0 -1.0 -1.8 0.4
Supplements: Calcium 0.9 1.0 3.2 1.8 -0.8 1.0 -0.1 -0.6
Basal cell carcinoma (self-reported) 0.5 0.6 0.9 -0.9 0.8 -0.6 0.9 0.5
Heart attack/myocardial infarction (self-reported) 3.6 4.6 9.4 -2.9 1.3 1.7 3.1 -0.8
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.3 0.1 0.1 0.9 -0.0 -1.1
Heart disease (siblings) 0.2 0.2 0.7 -0.3 0.2 -0.2 0.7 0.8
Alcohol drinker status: Previous 3.8 4.3 8.7 -2.2 -0.5 2.9 2.7 -0.7
Pack years of smoking 0.9 1.3 3.1 -1.2 0.7 1.8 1.0 -0.4
Impedance of whole body 1.1 5.5 14.7 2.2 -0.9 -2.4 -3.8 1.2
Leg fat mass (left) 1.3 5.0 13.5 -3.7 1.1 2.3 2.1 -0.5
Arm predicted mass (left) 0.5 2.5 10.6 -3.2 -0.1 1.0 1.1 -0.0