Hub : Traits :

Leg pain on walking

22 significantly associated models · 7 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 49016056 50800146 7 1 9.3e-09 2.1e-07 0.038 84 IP6K1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 15.0 1 1 3 0 1 IP6K1
Irritable Bowel Disease (IBD) 28.6 1 1 3 0 1 IP6K1
Ulcerative Colitis (UC) 30.5 1 1 3 0 1 IP6K1
Verbal and Numeric Reasoning (VNR) 17.1 1 1 3 0 1 IP6K1
Breast Cancer 4.3 1 0 0 0 1 IP6K1
Prostate Cancer 11.1 1 0 0 0 1 IP6K1
Age at First Birth 33.6 1 1 3 0 1 IP6K1
Crohns Disease (2012) 15.0 1 0 0 0 1 IP6K1
Ulcerative Colitis 34.3 1 1 3 0 1 IP6K1
Blood White Count 4.9 1 1 3 0 1 IP6K1
BMI 14.3 1 1 3 0 1 IP6K1
Height 0.8 1 0 0 0 1 IP6K1
Smoking Status 6.1 1 0 0 0 1 IP6K1
Lung FVC 4.2 1 0 0 0 1 IP6K1
Neuroticism 5.6 1 0 0 0 1 IP6K1
Chronotype (morning person) 8.4 1 0 0 0 1 IP6K1
Number of treatments/medications taken 12.1 1 0 0 0 1 IP6K1
Ever had hysterectomy (womb removed) 10.6 1 0 0 0 1 IP6K1
Medication: Co-codamol 15.4 1 0 0 0 1 IP6K1
Impedance of leg (right) 5.0 1 0 0 0 1 IP6K1
Leg fat-free mass (left) 5.2 1 1 3 0 1 IP6K1
Trunk fat percentage 5.0 1 0 0 0 1 IP6K1
Fed-up feelings 18.0 1 1 3 0 1 IP6K1
Taking other prescription medications 16.8 1 1 3 0 1 IP6K1
Age when periods started (menarche) 17.3 1 1 3 0 1 IP6K1
Qualifications: CSEs or equivalent 14.2 1 0 0 0 1 IP6K1
Body mass index (BMI) 16.9 1 1 3 0 1 IP6K1
Impedance of leg (left) 5.6 1 1 3 0 1 IP6K1
Leg predicted mass (left) 5.2 1 1 3 0 1 IP6K1
Trunk fat mass 6.7 1 1 3 0 1 IP6K1
Waist circumference 6.2 1 0 0 0 1 IP6K1
Frequency of tenseness / restlessness in last 2 weeks 13.9 1 0 0 0 1 IP6K1
Forced vital capacity (FVC) 3.8 1 0 0 0 1 IP6K1
Ever unenthusiastic/disinterested for a whole week 8.9 1 0 0 0 1 IP6K1
Qualifications: None of the above 17.8 1 1 3 0 1 IP6K1
Pain all over the body in last month 11.8 1 0 0 0 1 IP6K1
Fluid intelligence score 11.7 1 0 0 0 1 IP6K1
Neuroticism score 5.2 1 0 0 0 1 IP6K1
Weight 9.3 1 1 3 0 1 IP6K1
Impedance of arm (right) 13.4 1 1 3 0 1 IP6K1
Arm fat percentage (right) 9.0 1 1 3 0 1 IP6K1
Trunk fat-free mass 4.1 1 0 0 0 1 IP6K1
Hip circumference 7.2 1 1 3 0 1 IP6K1
Alcohol intake versus 10 years previously 15.6 1 0 0 0 1 IP6K1
Father's age at death 8.5 1 0 0 0 1 IP6K1
Frequency of tiredness / lethargy in last 2 weeks 15.4 1 0 0 0 1 IP6K1
Forced expiratory volume in 1-second (FEV1) 4.5 1 0 0 0 1 IP6K1
Qualifications: A levels/AS levels or equivalent 24.2 1 1 3 0 1 IP6K1
Mouth/teeth dental problems: Dentures 8.6 1 0 0 0 1 IP6K1
Forced expiratory volume in 1-second (FEV1), Best measure 6.6 1 0 0 0 1 IP6K1
Impedance of arm (left) 15.2 1 1 3 0 1 IP6K1
Arm fat mass (right) 12.0 1 1 3 0 1 IP6K1
Trunk predicted mass 3.9 1 0 0 0 1 IP6K1
Seen doctor (GP) for nerves, anxiety, tension or depression 7.3 1 0 0 0 1 IP6K1
Ever highly irritable/argumentative for 2 days 17.9 1 0 0 0 1 IP6K1
Medication: Paracetamol 10.5 1 0 0 0 1 IP6K1
Chronic bronchitis/emphysema (mother) 9.3 1 0 0 0 1 IP6K1
Forced vital capacity (FVC), Best measure 5.5 1 0 0 0 1 IP6K1
Body fat percentage 7.8 1 1 3 0 1 IP6K1
Leg fat percentage (right) 13.3 1 1 3 0 1 IP6K1
Arm fat-free mass (right) 6.7 1 1 3 0 1 IP6K1
Exposure to tobacco smoke outside home 12.9 1 0 0 0 1 IP6K1
Worry too long after embarrassment 5.6 1 0 0 0 1 IP6K1
Wheeze or whistling in the chest in last year 11.7 1 0 0 0 1 IP6K1
Number of children fathered 8.4 1 0 0 0 1 IP6K1
Age at first live birth 26.3 1 1 3 0 1 IP6K1
Qualifications: College or University degree 38.5 1 1 3 0 1 IP6K1
Neck or shoulder pain in last month 8.6 1 0 0 0 1 IP6K1
Medication: Omeprazole 8.1 1 0 0 0 1 IP6K1
Whole body fat mass 10.5 1 1 3 0 1 IP6K1
Leg fat mass (right) 13.6 1 1 3 0 1 IP6K1
Arm predicted mass (right) 7.3 1 1 3 0 1 IP6K1
Alcohol intake frequency. 8.2 1 0 0 0 1 IP6K1
Comparative height size at age 10 2.4 1 0 0 0 1 IP6K1
Overall health rating 23.7 1 1 3 0 1 IP6K1
Chest pain or discomfort 7.7 1 0 0 0 1 IP6K1
Age at last live birth 27.9 1 1 3 0 1 IP6K1
Knee pain experienced in last month 15.3 1 0 0 0 1 IP6K1
Whole body fat-free mass 5.0 1 1 3 0 1 IP6K1
Leg fat-free mass (right) 4.4 1 0 0 0 1 IP6K1
Arm fat percentage (left) 8.2 1 1 3 0 1 IP6K1
Mood swings 12.1 1 0 0 0 1 IP6K1
Loneliness, isolation 9.4 1 0 0 0 1 IP6K1
Qualifications: nursing, teaching 7.8 1 0 0 0 1 IP6K1
Osteoarthritis (self-reported) 12.5 1 0 0 0 1 IP6K1
Forced expiratory volume in 1-second (FEV1), predicted percentage 7.1 1 0 0 0 1 IP6K1
Whole body water mass 5.0 1 1 3 0 1 IP6K1
Leg predicted mass (right) 4.2 1 0 0 0 1 IP6K1
Arm fat mass (left) 11.2 1 1 3 0 1 IP6K1
Number of self-reported non-cancer illnesses 5.3 1 0 0 0 1 IP6K1
Miserableness 19.1 1 1 3 0 1 IP6K1
Guilty feelings 7.6 1 0 0 0 1 IP6K1
Medication: Paracetamol 13.2 1 0 0 0 1 IP6K1
Basal metabolic rate 6.3 1 1 3 0 1 IP6K1
Leg fat percentage (left) 13.0 1 1 3 0 1 IP6K1
Arm fat-free mass (left) 8.2 1 1 3 0 1 IP6K1
Number of operations (self-reported) 12.0 1 0 0 0 1 IP6K1
Average weekly beer plus cider intake 12.6 1 0 0 0 1 IP6K1
Diastolic blood pressure, automated reading 4.9 1 0 0 0 1 IP6K1
Ever depressed for a whole week 8.3 1 0 0 0 1 IP6K1
Pain experienced in last month 16.4 1 1 3 0 1 IP6K1
Impedance of whole body 12.0 1 1 3 0 1 IP6K1
Leg fat mass (left) 13.8 1 1 3 0 1 IP6K1
Arm predicted mass (left) 8.3 1 1 3 0 1 IP6K1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.23
GTEx Adipose Visceral Omentum 0 0.0000 1.32
GTEx Adrenal Gland 0 0.0000 1.32
GTEx Artery Aorta 1 0.0336 1.28
GTEx Artery Coronary 1 0.0845 1.31
GTEx Artery Tibial 4 0.1064 1.29
GTEx Brain Caudate basal ganglia 0 0.0000 1.21
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.30
GTEx Brain Cerebellum 1 0.0505 1.31
GTEx Brain Cortex 0 0.0000 1.34
GTEx Brain Frontal Cortex BA9 0 0.0000 1.28
GTEx Brain Hippocampus 0 0.0000 1.24
GTEx Brain Hypothalamus 0 0.0000 1.25
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.29
GTEx Brain Putamen basal ganglia 0 0.0000 1.37
GTEx Breast Mammary Tissue 1 0.0507 1.27
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.25
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.21
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.39
GTEx Cells Transformed fibroblasts 0 0.0000 1.26
GTEx Colon Sigmoid 0 0.0000 1.34
GTEx Colon Transverse 1 0.0484 1.26
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.28
GTEx Esophagus Mucosa 1 0.0301 1.32
GTEx Esophagus Muscularis 0 0.0000 1.26
GTEx Heart Atrial Appendage 0 0.0000 1.32
GTEx Heart Left Ventricle 1 0.0654 1.42
GTEx Liver 1 0.1395 1.39
GTEx Lung 1 0.0348 1.28
GTEx Muscle Skeletal 1 0.0346 1.23
GTEx Nerve Tibial 0 0.0000 1.26
GTEx Ovary 0 0.0000 1.40
GTEx Pancreas 0 0.0000 1.30
GTEx Pituitary 1 0.0897 1.28
GTEx Prostate 0 0.0000 1.34
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.33
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.30
GTEx Small Intestine Terminal Ileum 0 0.0000 1.36
GTEx Spleen 1 0.0709 1.34
GTEx Stomach 0 0.0000 1.32
GTEx Testis 0 0.0000 1.30
GTEx Thyroid 1 0.0250 1.30
GTEx Uterus 0 0.0000 1.35
GTEx Vagina 1 0.1575 1.34
GTEx Whole Blood 1 0.0502 1.28
METSIM Adipose 1 0.0217 1.24
NTR Blood 0 0.0000 1.23
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.25
YFS Blood 0 0.0000 1.18
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.21
TCGA Breast Tumor 0 0.0000 1.31
TCGA Breast Normal 0 0.0000 1.18
TCGA Ovarian Tumor 1 0.0342 1.20
TCGA Prostate Tumor 0 0.0000 1.20