Hub : Traits :

Illnesses of father: High blood pressure

13 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 11 46723603 48128751 1 1 6.4e-08 6.3e-08 1.00 100 RP11-750H9.5
2 15 90730363 92135418 1 1 1.2e-12 2.2e-11 0.94 100 FES
3 16 89037130 90172696 1 1 1.8e-07 9.8e-08 0.22 95 SPATA33

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 7.01 1 0 0.0 0 1 RP11-750H9.5
Crohns Disease (2017) 2.10 1 0 0.0 0 1 FES
Irritable Bowel Disease (IBD) 1.69 1 0 0.0 0 1 FES
Major Depression (MDD) 4.30 1 0 0.0 0 1 FES
Breast Cancer 5.13 2 0 0.0 0 1 FES RP11-750H9.5
Ovarian Cancer 3.82 1 0 0.0 0 1 FES
Prostate Cancer 3.64 1 0 0.0 0 1 RP11-750H9.5
Body Mass Index (BMI) (2010) 3.73 1 0 0.0 0 1 RP11-750H9.5
Crohns Disease (2012) 2.27 1 0 0.0 0 1 FES
Fasting Glucose 7.18 1 0 0.0 0 1 RP11-750H9.5
HbA1C 2.83 1 0 0.0 0 1 SPATA33
Neuroticism 5.37 1 0 0.0 0 1 RP11-750H9.5
Schizophrenia 8.01 2 1 3.0 0 1 FES SPATA33
Blood Eosinophil Count 1.35 1 1 3.0 0 1 RP11-750H9.5
Blood Red Count 2.32 3 1 3.0 0 1 FES RP11-750H9.5 SPATA33
Blood White Count 2.10 1 1 3.0 0 1 FES
Heel T-Score 0.45 1 0 0.0 0 1 RP11-750H9.5
BMI 2.81 1 1 3.0 0 1 RP11-750H9.5
Height 0.34 1 0 0.0 0 1 FES
Waist Hip Ratio (WHR) 1.30 1 0 0.0 0 1 RP11-750H9.5
Systolic Blood Pressure 27.71 3 2 6.1 0 1 FES RP11-750H9.5 SPATA33
Smoking Status 3.39 1 0 0.0 0 1 FES
Allergy or Eczema 2.46 1 0 0.0 0 1 FES
Cardiovascular Disease 22.07 3 3 9.1 0 1 FES RP11-750H9.5 SPATA33
Hypothyroidism (self reported) 2.18 1 0 0.0 0 1 RP11-750H9.5
Respiratory disease 2.50 1 0 0.0 0 1 FES
Neuroticism 4.05 1 1 3.0 0 1 RP11-750H9.5
Hair Pigment 50.45 2 2 6.1 0 1 FES SPATA33
Tanning 71.40 2 1 3.0 0 1 RP11-750H9.5 SPATA33
Hand grip strength (left) 2.90 1 0 0.0 0 1 RP11-750H9.5
Number of treatments/medications taken 3.49 1 0 0.0 0 1 FES
Sensitivity / hurt feelings 3.04 1 0 0.0 0 1 FES
Frequency of depressed mood in last 2 weeks 4.57 1 0 0.0 0 1 RP11-750H9.5
Systolic blood pressure, automated reading 16.27 2 1 3.0 0 1 FES RP11-750H9.5
Angina 9.41 1 1 3.0 0 1 FES
Medication: Metformin 3.41 1 0 0.0 0 1 RP11-750H9.5
Severe depression (siblings) 5.60 1 0 0.0 0 1 SPATA33
Impedance of leg (right) 3.73 2 1 3.0 0 1 FES RP11-750H9.5
Leg fat-free mass (left) 2.08 2 0 0.0 0 1 FES RP11-750H9.5
Trunk fat percentage 3.83 1 1 3.0 0 1 RP11-750H9.5
Hand grip strength (right) 2.05 1 0 0.0 0 1 RP11-750H9.5
Current tobacco smoking 3.10 1 0 0.0 0 1 FES
Fed-up feelings 3.30 1 0 0.0 0 1 RP11-750H9.5
Age when periods started (menarche) 1.56 1 0 0.0 0 1 RP11-750H9.5
High blood pressure 26.83 3 3 9.1 0 1 FES RP11-750H9.5 SPATA33
Stomach or abdominal pain in last month 5.42 2 0 0.0 0 1 RP11-750H9.5 SPATA33
Medication: Atenolol 13.91 2 1 3.0 0 1 FES SPATA33
Sitting height 1.30 2 0 0.0 0 1 FES RP11-750H9.5
High blood pressure (mother) 24.86 2 1 3.0 0 1 FES SPATA33
Body mass index (BMI) 2.66 1 1 3.0 0 1 RP11-750H9.5
Impedance of leg (left) 3.62 2 1 3.0 0 1 FES RP11-750H9.5
Leg predicted mass (left) 2.12 2 0 0.0 0 1 FES RP11-750H9.5
Trunk fat mass 3.24 1 1 3.0 0 1 RP11-750H9.5
Waist circumference 3.81 1 1 3.0 0 1 RP11-750H9.5
Number of incorrect matches in round 4.12 1 0 0.0 0 1 FES
Alcohol usually taken with meals 2.58 1 0 0.0 0 1 FES
Nervous feelings 4.07 1 0 0.0 0 1 RP11-750H9.5
Frequency of tenseness / restlessness in last 2 weeks 2.79 1 0 0.0 0 1 RP11-750H9.5
Mouth/teeth dental problems 2.50 1 0 0.0 0 1 RP11-750H9.5
Heart attack 5.20 1 0 0.0 0 1 FES
Allergy 2.52 1 0 0.0 0 1 FES
Medication: Ramipril 7.81 2 0 0.0 0 1 FES RP11-750H9.5
Medication: Simvastatin 6.25 1 0 0.0 0 1 FES
Illnesses of siblings 7.00 1 1 3.0 0 1 FES
Neuroticism score 5.27 1 1 3.0 0 1 RP11-750H9.5
Weight 1.97 1 0 0.0 0 1 RP11-750H9.5
Arm fat percentage (right) 4.39 2 1 3.0 0 1 RP11-750H9.5 SPATA33
Hip circumference 1.60 1 0 0.0 0 1 RP11-750H9.5
Father's age at death 5.37 1 0 0.0 0 1 FES
Worrier / anxious feelings 1.61 1 0 0.0 0 1 RP11-750H9.5
Pulse rate 1.76 1 0 0.0 0 1 RP11-750H9.5
Medication: Cholesterol lowering 6.55 1 1 3.0 0 1 FES
Lung cancer (father) 3.89 1 0 0.0 0 1 FES
Illnesses of mother 15.37 2 1 3.0 0 1 FES RP11-750H9.5
Arm fat mass (right) 3.30 1 1 3.0 0 1 RP11-750H9.5
Breastfed as a baby 3.30 1 0 0.0 0 1 FES
Tense / 'highly strung' 3.48 1 0 0.0 0 1 RP11-750H9.5
Hair/balding pattern: Pattern 4 3.87 2 0 0.0 0 1 FES SPATA33
Birth weight of first child 9.41 1 1 3.0 0 1 FES
Mouth/teeth dental problems: Bleeding gums 4.01 1 0 0.0 0 1 RP11-750H9.5
Headache pain in last month 2.65 1 0 0.0 0 1 FES
Medication for cholesterol, blood pressure or diabetes 15.20 1 1 3.0 0 1 FES
Medication: Amlodipine 12.50 2 1 3.0 0 1 FES SPATA33
Birth weight 5.17 1 1 3.0 0 1 FES
High blood pressure (siblings) 12.72 2 1 3.0 0 1 FES RP11-750H9.5
Body fat percentage 3.05 1 1 3.0 0 1 RP11-750H9.5
Leg fat percentage (right) 1.50 1 0 0.0 0 1 RP11-750H9.5
Comparative body size at age 10 3.85 1 1 3.0 0 1 RP11-750H9.5
Pulse wave peak to peak time 3.06 1 0 0.0 0 1 FES
Medication: Blood pressure 21.44 3 1 3.0 0 1 FES RP11-750H9.5 SPATA33
Angina (self-reported) 9.42 1 1 3.0 0 1 FES
Mean time to correctly identify matches 2.10 1 0 0.0 0 1 FES
Heart disease (mother) 5.24 1 0 0.0 0 1 FES
Whole body fat mass 2.71 1 1 3.0 0 1 RP11-750H9.5
Leg fat mass (right) 1.80 1 0 0.0 0 1 RP11-750H9.5
Pulse rate, automated reading 2.29 1 0 0.0 0 1 RP11-750H9.5
Alcohol intake frequency. 2.55 1 0 0.0 0 1 RP11-750H9.5
Comparative height size at age 10 0.85 1 0 0.0 0 1 FES
Suffer from 'nerves' 5.27 1 0 0.0 0 1 RP11-750H9.5
Illness, injury, bereavement, stress in last 2 years 3.30 1 0 0.0 0 1 RP11-750H9.5
Medication: Aspirin 8.73 1 1 3.0 0 1 FES
Hypertension (Self-reported) 27.89 3 3 9.1 0 1 FES RP11-750H9.5 SPATA33
Illnesses of father: Heart disease 12.22 1 1 3.0 0 1 FES
Leg fat-free mass (right) 2.17 2 0 0.0 0 1 FES RP11-750H9.5
Arm fat percentage (left) 4.57 1 1 3.0 0 1 RP11-750H9.5
Mood swings 9.80 1 1 3.0 0 1 RP11-750H9.5
Loneliness, isolation 5.38 1 0 0.0 0 1 RP11-750H9.5
Medication for cholesterol 5.65 2 0 0.0 0 1 FES SPATA33
Osteoarthritis (self-reported) 2.23 1 0 0.0 0 1 SPATA33
Medication: Aspirin 10.36 1 1 3.0 0 1 FES
Illnesses of father: None of the above (group 1) 12.38 1 1 3.0 0 1 FES
Smoking status: Current 3.40 1 0 0.0 0 1 FES
Whole body water mass 0.94 1 0 0.0 0 1 RP11-750H9.5
Leg predicted mass (right) 2.18 2 0 0.0 0 1 FES RP11-750H9.5
Arm fat mass (left) 3.58 1 1 3.0 0 1 RP11-750H9.5
Number of self-reported non-cancer illnesses 2.70 1 0 0.0 0 1 FES
Average weekly champagne plus white wine intake 3.05 1 0 0.0 0 1 RP11-750H9.5
Miserableness 7.58 1 1 3.0 0 1 RP11-750H9.5
Guilty feelings 3.66 1 0 0.0 0 1 RP11-750H9.5
Medication: Blood pressure 18.94 3 2 6.1 0 1 FES RP11-750H9.5 SPATA33
High cholesterol (Self-reported) 1.97 1 0 0.0 0 1 FES
Medication: Bendroflumethiazide 11.59 3 0 0.0 0 1 FES RP11-750H9.5 SPATA33
Medication: Lisinopril 6.74 2 0 0.0 0 1 FES SPATA33
Ever smoked 2.24 1 0 0.0 0 1 FES
Basal metabolic rate 1.10 1 0 0.0 0 1 RP11-750H9.5
Leg fat percentage (left) 1.46 1 0 0.0 0 1 RP11-750H9.5
Risk taking 2.85 1 0 0.0 0 1 FES
Diastolic blood pressure, automated reading 16.24 3 2 6.1 0 1 FES RP11-750H9.5 SPATA33
Vascular/heart problems diagnosed by doctor 27.04 3 3 9.1 0 1 FES RP11-750H9.5 SPATA33
Pain experienced in last month 2.96 1 0 0.0 0 1 SPATA33
Basal cell carcinoma (self-reported) 3.71 1 0 0.0 0 1 SPATA33
Heart attack/myocardial infarction (self-reported) 5.52 1 0 0.0 0 1 FES
Heart disease (siblings) 5.57 1 0 0.0 0 1 FES
Leg fat mass (left) 1.90 1 0 0.0 0 1 RP11-750H9.5

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.27
GTEx Adipose Visceral Omentum 2 0.0982 1.29
GTEx Adrenal Gland 0 0.0000 1.25
GTEx Artery Aorta 0 0.0000 1.28
GTEx Artery Coronary 0 0.0000 1.26
GTEx Artery Tibial 1 0.0266 1.29
GTEx Brain Caudate basal ganglia 0 0.0000 1.31
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.28
GTEx Brain Cerebellum 0 0.0000 1.24
GTEx Brain Cortex 0 0.0000 1.26
GTEx Brain Frontal Cortex BA9 0 0.0000 1.33
GTEx Brain Hippocampus 0 0.0000 1.26
GTEx Brain Hypothalamus 0 0.0000 1.15
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.25
GTEx Brain Putamen basal ganglia 0 0.0000 1.29
GTEx Breast Mammary Tissue 0 0.0000 1.22
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.25
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.31
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.22
GTEx Cells Transformed fibroblasts 1 0.0238 1.29
GTEx Colon Sigmoid 0 0.0000 1.24
GTEx Colon Transverse 0 0.0000 1.27
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.26
GTEx Esophagus Mucosa 0 0.0000 1.25
GTEx Esophagus Muscularis 0 0.0000 1.28
GTEx Heart Atrial Appendage 0 0.0000 1.22
GTEx Heart Left Ventricle 0 0.0000 1.23
GTEx Liver 0 0.0000 1.13
GTEx Lung 1 0.0348 1.27
GTEx Muscle Skeletal 0 0.0000 1.27
GTEx Nerve Tibial 0 0.0000 1.27
GTEx Ovary 0 0.0000 1.19
GTEx Pancreas 0 0.0000 1.23
GTEx Pituitary 0 0.0000 1.27
GTEx Prostate 0 0.0000 1.37
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.30
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.29
GTEx Small Intestine Terminal Ileum 0 0.0000 1.15
GTEx Spleen 0 0.0000 1.28
GTEx Stomach 0 0.0000 1.32
GTEx Testis 0 0.0000 1.25
GTEx Thyroid 1 0.0250 1.29
GTEx Uterus 0 0.0000 1.22
GTEx Vagina 0 0.0000 1.20
GTEx Whole Blood 0 0.0000 1.23
METSIM Adipose 1 0.0217 1.20
NTR Blood 0 0.0000 1.19
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.27
YFS Blood 0 0.0000 1.19
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.23
TCGA Breast Tumor 0 0.0000 1.15
TCGA Breast Normal 1 0.0238 1.23
TCGA Ovarian Tumor 1 0.0342 1.19
TCGA Prostate Tumor 1 0.0289 1.24