Hub : Traits :

Risk taking

40 significantly associated models · 14 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 242590540 244359621 2 1 3.0e-10 2.1e-07 6.7e-03 73 CEP170
2 2 26505858 28038799 3 1 2.9e-09 2.7e-08 1.0e+00 100 KHK
3 3 84317575 86808226 1 1 5.8e-13 1.9e-18 9.0e-08 63 CADM2
4 4 151920705 153373680 1 1 9.7e-08 3.7e-08 1.5e-01 93 PET112
5 8 9263290 11662885 3 1 2.0e-07 1.6e-07 3.3e-02 84 AF131215.2
6 14 103466633 105211221 4 1 6.9e-08 2.1e-07 5.3e-01 98 XRCC3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Irritable Bowel Disease (IBD) 1.31 1 0 0.0 0.00 1.0000 CADM2
Ulcerative Colitis (UC) 1.87 1 0 0.0 0.00 1.0000 CADM2
Reaction Time 1.76 1 0 0.0 0.00 1.0000 PET112
Verbal and Numeric Reasoning (VNR) 4.14 2 1 3.0 0.00 1.0000 KHK PET112
Body Mass Index (BMI) (2010) 2.74 1 0 0.0 0.00 1.0000 CADM2
Fasting Glucose 2.21 1 0 0.0 0.00 1.0000 KHK
Lupus 2.30 1 0 0.0 0.00 1.0000 AF131215.2
Neuroticism 7.38 1 1 3.0 0.00 1.0000 AF131215.2
Schizophrenia 5.98 2 2 6.1 0.00 1.0000 CEP170 XRCC3
Triglycerides 2.36 1 0 0.0 0.00 1.0000 AF131215.2
Blood Platelet Count 1.39 1 1 3.0 0.00 1.0000 PET112
Blood Red Count 0.83 2 0 0.0 0.00 1.0000 KHK XRCC3
Blood White Count 1.82 3 2 6.1 0.00 1.0000 KHK PET112 XRCC3
Heel T-Score 1.98 2 1 3.0 0.00 1.0000 CEP170 XRCC3
BMI 3.32 4 2 6.1 -0.57 0.4259 CADM2 CEP170 KHK XRCC3
Height 1.20 4 2 6.1 0.66 0.3363 CEP170 KHK PET112 XRCC3
Systolic Blood Pressure 1.08 1 1 3.0 0.00 1.0000 CADM2
Smoking Status 4.25 2 1 3.0 0.00 1.0000 CADM2 XRCC3
Cardiovascular Disease 2.05 1 0 0.0 0.00 1.0000 XRCC3
Lung FEV1/FVC ratio 1.03 2 0 0.0 0.00 1.0000 CADM2 XRCC3
Neuroticism 2.45 1 0 0.0 0.00 1.0000 CADM2
Hair Pigment 0.29 1 1 3.0 0.00 1.0000 XRCC3
Tanning 0.77 1 1 3.0 0.00 1.0000 CADM2
Hand grip strength (left) 1.92 2 0 0.0 0.00 1.0000 CADM2 PET112
Sensitivity / hurt feelings 4.34 1 1 3.0 0.00 1.0000 AF131215.2
Frequency of depressed mood in last 2 weeks 3.00 1 0 0.0 0.00 1.0000 AF131215.2
Relative age of first facial hair 2.67 2 0 0.0 0.00 1.0000 CEP170 XRCC3
Systolic blood pressure, automated reading 2.50 1 1 3.0 0.00 1.0000 AF131215.2
Medication for hormone replacement therapy 3.02 1 0 0.0 0.00 1.0000 KHK
Pack years adult smoking proportion 3.53 1 0 0.0 0.00 1.0000 XRCC3
Impedance of leg (right) 5.54 4 2 6.1 -0.54 0.4595 AF131215.2 CADM2 PET112 XRCC3
Leg fat-free mass (left) 4.03 5 2 6.1 0.34 0.5794 AF131215.2 CADM2 CEP170 KHK PET112
Trunk fat percentage 1.88 1 1 3.0 0.00 1.0000 KHK
Hand grip strength (right) 1.54 1 0 0.0 0.00 1.0000 PET112
Current tobacco smoking 4.11 2 0 0.0 0.00 1.0000 AF131215.2 XRCC3
Maternal smoking around birth 2.13 1 0 0.0 0.00 1.0000 XRCC3
Fed-up feelings 4.64 2 1 3.0 0.00 1.0000 AF131215.2 CEP170
Heel bone mineral density (BMD) T-score, automated (left) 7.14 1 1 3.0 0.00 1.0000 AF131215.2
High blood pressure 3.82 1 1 3.0 0.00 1.0000 AF131215.2
Medication: Levothyroxine sodium 2.19 1 0 0.0 0.00 1.0000 AF131215.2
Sitting height 0.76 1 0 0.0 0.00 1.0000 CEP170
Body mass index (BMI) 5.18 3 2 6.1 0.00 1.0000 AF131215.2 CADM2 XRCC3
Impedance of leg (left) 5.60 4 2 6.1 -0.55 0.4463 AF131215.2 CADM2 PET112 XRCC3
Leg predicted mass (left) 4.05 5 2 6.1 0.33 0.5862 AF131215.2 CADM2 CEP170 KHK PET112
Trunk fat mass 2.46 3 0 0.0 0.00 1.0000 AF131215.2 CADM2 KHK
Waist circumference 3.41 3 1 3.0 0.00 1.0000 CADM2 KHK XRCC3
Past tobacco smoking 6.08 1 1 3.0 0.00 1.0000 CADM2
Alcohol usually taken with meals 1.61 1 0 0.0 0.00 1.0000 AF131215.2
Nervous feelings 11.29 2 2 6.1 0.00 1.0000 AF131215.2 CADM2
Hearing difficulty/problems with background noise 2.22 1 0 0.0 0.00 1.0000 XRCC3
Forced vital capacity (FVC) 1.92 2 0 0.0 0.00 1.0000 CEP170 PET112
Heel bone mineral density (BMD) T-score, automated (right) 7.27 1 1 3.0 0.00 1.0000 AF131215.2
Qualifications: None of the above 2.46 1 0 0.0 0.00 1.0000 PET112
Financial difficulties in last 2 years 3.42 1 0 0.0 0.00 1.0000 XRCC3
Mouth/teeth dental problems 4.60 2 0 0.0 0.00 1.0000 PET112 XRCC3
Fluid intelligence score 3.98 2 0 0.0 0.00 1.0000 KHK PET112
Neuroticism score 9.41 2 1 3.0 0.00 1.0000 AF131215.2 CADM2
Weight 3.72 4 2 6.1 0.63 0.3697 AF131215.2 CADM2 CEP170 KHK
Impedance of arm (right) 5.29 2 2 6.1 0.00 1.0000 AF131215.2 CADM2
Arm fat percentage (right) 2.83 3 0 0.0 0.00 1.0000 AF131215.2 CADM2 XRCC3
Trunk fat-free mass 2.99 4 1 3.0 -0.08 0.9248 AF131215.2 CADM2 CEP170 PET112
Hip circumference 2.78 3 0 0.0 0.00 1.0000 AF131215.2 CADM2 KHK
Father's age at death 2.22 1 0 0.0 0.00 1.0000 AF131215.2
Worrier / anxious feelings 11.81 2 2 6.1 0.00 1.0000 AF131215.2 CADM2
Frequency of tiredness / lethargy in last 2 weeks 4.68 1 0 0.0 0.00 1.0000 XRCC3
Forced expiratory volume in 1-second (FEV1) 2.95 2 1 3.0 0.00 1.0000 AF131215.2 CEP170
Qualifications: A levels/AS levels or equivalent 3.28 2 0 0.0 0.00 1.0000 KHK PET112
Serious illness, injury or assault of a close relative in last 2 years 3.71 1 0 0.0 0.00 1.0000 AF131215.2
Mouth/teeth dental problems: Dentures 2.86 1 0 0.0 0.00 1.0000 AF131215.2
Medication: Ibuprofen (e.g. Nurofen) 4.00 1 0 0.0 0.00 1.0000 PET112
Forced expiratory volume in 1-second (FEV1), Best measure 2.60 2 0 0.0 0.00 1.0000 AF131215.2 CEP170
Impedance of arm (left) 5.47 2 2 6.1 0.00 1.0000 AF131215.2 CADM2
Arm fat mass (right) 3.83 4 2 6.1 0.97 0.0287 AF131215.2 CADM2 KHK XRCC3
Trunk predicted mass 2.98 4 1 3.0 -0.07 0.9268 AF131215.2 CADM2 CEP170 PET112
Standing height 1.41 4 0 0.0 -0.63 0.3704 AF131215.2 CEP170 KHK PET112
Length of working week for main job 2.49 1 0 0.0 0.00 1.0000 AF131215.2
Tense / 'highly strung' 8.17 2 2 6.1 0.00 1.0000 AF131215.2 CADM2
Peak expiratory flow (PEF) 2.97 2 0 0.0 0.00 1.0000 AF131215.2 CADM2
Ever highly irritable/argumentative for 2 days 3.24 1 0 0.0 0.00 1.0000 PET112
Qualifications: O levels/GCSEs or equivalent 3.93 1 0 0.0 0.00 1.0000 PET112
Medication: Paracetamol 3.29 1 0 0.0 0.00 1.0000 CEP170
Headache pain in last month 4.56 2 1 3.0 0.00 1.0000 AF131215.2 CEP170
Hypothyroidism/myxoedema (self-reported) 3.03 1 1 3.0 0.00 1.0000 AF131215.2
Forced vital capacity (FVC), Best measure 1.45 2 0 0.0 0.00 1.0000 CEP170 PET112
Body fat percentage 2.11 1 0 0.0 0.00 1.0000 KHK
Leg fat percentage (right) 2.46 2 0 0.0 0.00 1.0000 AF131215.2 CADM2
Arm fat-free mass (right) 3.87 3 2 6.1 0.00 1.0000 AF131215.2 CADM2 CEP170
Comparative body size at age 10 5.79 2 2 6.1 0.00 1.0000 AF131215.2 CADM2
Worry too long after embarrassment 6.57 2 1 3.0 0.00 1.0000 AF131215.2 CADM2
Wheeze or whistling in the chest in last year 2.66 1 0 0.0 0.00 1.0000 AF131215.2
Number of children fathered 5.27 1 0 0.0 0.00 1.0000 CADM2
Age at first live birth 3.56 1 0 0.0 0.00 1.0000 AF131215.2
Qualifications: College or University degree 3.30 3 1 3.0 0.00 1.0000 CEP170 PET112 XRCC3
Emphysema/chronic bronchitis 4.17 1 0 0.0 0.00 1.0000 XRCC3
Medication for pain relief, constipation, heartburn 4.03 1 0 0.0 0.00 1.0000 CEP170
Medication: Ibuprofen 2.93 1 0 0.0 0.00 1.0000 PET112
Mean time to correctly identify matches 1.69 1 0 0.0 0.00 1.0000 PET112
Whole body fat mass 2.93 3 0 0.0 0.00 1.0000 AF131215.2 CADM2 KHK
Leg fat mass (right) 3.82 3 2 6.1 0.00 1.0000 AF131215.2 CADM2 KHK
Arm predicted mass (right) 3.80 3 2 6.1 0.00 1.0000 AF131215.2 CADM2 CEP170
Pulse rate, automated reading 1.08 1 0 0.0 0.00 1.0000 CEP170
Alcohol intake frequency. 2.44 1 1 3.0 0.00 1.0000 CADM2
Comparative height size at age 10 1.48 3 0 0.0 0.00 1.0000 CEP170 PET112 XRCC3
Number of full sisters 3.14 1 0 0.0 0.00 1.0000 CADM2
Suffer from 'nerves' 8.87 2 2 6.1 0.00 1.0000 AF131215.2 CADM2
Overall health rating 4.24 4 0 0.0 1.00 0.0014 AF131215.2 KHK PET112 XRCC3
Age at last live birth 3.77 2 0 0.0 0.00 1.0000 AF131215.2 CADM2
Knee pain experienced in last month 2.58 1 0 0.0 0.00 1.0000 CEP170
Hypertension (Self-reported) 3.38 1 1 3.0 0.00 1.0000 AF131215.2
Smoking status: Previous 4.56 1 1 3.0 0.00 1.0000 CADM2
Whole body fat-free mass 3.55 4 2 6.1 -0.05 0.9543 AF131215.2 CADM2 CEP170 PET112
Leg fat-free mass (right) 4.09 5 2 6.1 0.29 0.6334 AF131215.2 CADM2 CEP170 KHK PET112
Arm fat percentage (left) 2.75 4 0 0.0 0.96 0.0363 AF131215.2 CADM2 KHK XRCC3
Average weekly red wine intake 3.51 1 0 0.0 0.00 1.0000 CADM2
Mood swings 5.38 2 1 3.0 0.00 1.0000 AF131215.2 CEP170
Long-standing illness, disability or infirmity 2.48 1 0 0.0 0.00 1.0000 XRCC3
Qualifications: nursing, teaching 2.24 1 0 0.0 0.00 1.0000 PET112
Mouth/teeth dental problems: Mouth ulcers 2.20 1 0 0.0 0.00 1.0000 CADM2
Osteoporosis (self-reported) 2.19 1 0 0.0 0.00 1.0000 AF131215.2
Smoking status: Current 4.10 2 0 0.0 0.00 1.0000 AF131215.2 XRCC3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.64 1 0 0.0 0.00 1.0000 AF131215.2
Whole body water mass 3.61 4 2 6.1 -0.05 0.9513 AF131215.2 CADM2 CEP170 PET112
Leg predicted mass (right) 4.05 5 2 6.1 0.29 0.6324 AF131215.2 CADM2 CEP170 KHK PET112
Arm fat mass (left) 3.85 4 2 6.1 0.97 0.0260 AF131215.2 CADM2 KHK XRCC3
Number of self-reported non-cancer illnesses 1.87 1 0 0.0 0.00 1.0000 XRCC3
Miserableness 5.89 2 1 3.0 0.00 1.0000 AF131215.2 CEP170
Guilty feelings 3.10 1 0 0.0 0.00 1.0000 AF131215.2
Medication: Blood pressure 3.19 1 0 0.0 0.00 1.0000 AF131215.2
Medication: Bendroflumethiazide 2.82 1 0 0.0 0.00 1.0000 AF131215.2
Medication: Paracetamol 2.56 1 0 0.0 0.00 1.0000 CEP170
Ever smoked 4.29 1 1 3.0 0.00 1.0000 CADM2
Basal metabolic rate 3.71 3 2 6.1 0.00 1.0000 AF131215.2 CADM2 CEP170
Leg fat percentage (left) 2.69 2 0 0.0 0.00 1.0000 AF131215.2 CADM2
Arm fat-free mass (left) 3.82 3 2 6.1 0.00 1.0000 AF131215.2 CADM2 CEP170
Average weekly beer plus cider intake 2.87 1 0 0.0 0.00 1.0000 AF131215.2
Irritability 7.78 1 1 3.0 0.00 1.0000 AF131215.2
Diastolic blood pressure, automated reading 4.73 2 2 6.1 0.00 1.0000 AF131215.2 CEP170
Vascular/heart problems diagnosed by doctor 3.58 2 1 3.0 0.00 1.0000 AF131215.2 XRCC3
Pain experienced in last month 2.98 1 0 0.0 0.00 1.0000 PET112
Alcohol drinker status: Previous 2.38 1 0 0.0 0.00 1.0000 XRCC3
Pack years of smoking 3.17 1 0 0.0 0.00 1.0000 XRCC3
Impedance of whole body 6.11 2 2 6.1 0.00 1.0000 AF131215.2 CADM2
Leg fat mass (left) 3.95 3 2 6.1 0.00 1.0000 AF131215.2 CADM2 KHK
Arm predicted mass (left) 3.98 3 2 6.1 0.00 1.0000 AF131215.2 CADM2 CEP170

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.49
GTEx Adipose Visceral Omentum 0 0.0000 1.46
GTEx Adrenal Gland 0 0.0000 1.53
GTEx Artery Aorta 2 0.0672 1.47
GTEx Artery Coronary 0 0.0000 1.57
GTEx Artery Tibial 3 0.0798 1.52
GTEx Brain Caudate basal ganglia 0 0.0000 1.50
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.51
GTEx Brain Cerebellum 0 0.0000 1.47
GTEx Brain Cortex 1 0.0966 1.46
GTEx Brain Frontal Cortex BA9 0 0.0000 1.52
GTEx Brain Hippocampus 0 0.0000 1.31
GTEx Brain Hypothalamus 0 0.0000 1.36
GTEx Brain Nucleus accumbens basal ganglia 1 0.1156 1.43
GTEx Brain Putamen basal ganglia 0 0.0000 1.44
GTEx Breast Mammary Tissue 1 0.0507 1.53
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.43
GTEx Breast Mammary Tissue (Female) 1 0.0608 1.48
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.47
GTEx Cells Transformed fibroblasts 2 0.0476 1.53
GTEx Colon Sigmoid 0 0.0000 1.55
GTEx Colon Transverse 0 0.0000 1.53
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.53
GTEx Esophagus Mucosa 0 0.0000 1.51
GTEx Esophagus Muscularis 2 0.0619 1.50
GTEx Heart Atrial Appendage 1 0.0633 1.41
GTEx Heart Left Ventricle 1 0.0654 1.57
GTEx Liver 0 0.0000 1.45
GTEx Lung 1 0.0348 1.49
GTEx Muscle Skeletal 2 0.0692 1.52
GTEx Nerve Tibial 2 0.0463 1.48
GTEx Ovary 1 0.1101 1.51
GTEx Pancreas 0 0.0000 1.46
GTEx Pituitary 0 0.0000 1.44
GTEx Prostate 0 0.0000 1.65
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.47
GTEx Skin Sun Exposed Lower leg 3 0.0824 1.51
GTEx Small Intestine Terminal Ileum 1 0.2169 1.49
GTEx Spleen 1 0.0709 1.51
GTEx Stomach 0 0.0000 1.43
GTEx Testis 1 0.0317 1.54
GTEx Thyroid 1 0.0250 1.46
GTEx Uterus 1 0.1764 1.58
GTEx Vagina 0 0.0000 1.36
GTEx Whole Blood 0 0.0000 1.41
METSIM Adipose 1 0.0217 1.52
NTR Blood 1 0.0416 1.43
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.56
YFS Blood 1 0.0217 1.40
CommonMind Brain Pre-frontal Cortex 2 0.0372 1.46
TCGA Breast Tumor 2 0.2608 1.48
TCGA Breast Normal 1 0.0238 1.36
TCGA Ovarian Tumor 0 0.0000 1.42
TCGA Prostate Tumor 1 0.0289 1.44