TWAS hub - SPC25

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.1878	0.0361	8.3e-16	0.144	0.136	0.152	0.161	0.158	5.9e-21	1.0e-19	4.2e-22	2.6e-23	5.5e-23
2	ROSMAP	Brain Pre-frontal Cortex	0.0681	0.0379	4.0e-02	-0.002	-0.002	-0.002	0.006	-0.002	9.9e-01	9.2e-01	9.9e-01	5.3e-02	6.5e-01
3	TCGA	Breast Invasive Carcinoma	0.0301	0.0169	6.9e-03	0.027	0.014	0.027	NA	0.027	2.3e-06	6.1e-04	2.6e-06	NA	2.6e-06
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.3456	0.0765	0.0e+00	0.270	0.246	0.274	NA	0.272	2.1e-30	1.8e-27	6.9e-31	NA	1.2e-30
5	TCGA	Kidney Renal Papillary Cell Carcinoma	0.2110	0.0720	2.6e-09	0.169	0.189	0.180	NA	0.185	6.3e-10	5.2e-11	1.5e-10	NA	7.8e-11
6	TCGA	Pancreatic Adenocarcinoma	0.2130	0.0840	2.0e-03	0.009	0.054	0.083	NA	0.067	1.3e-01	2.6e-03	2.4e-04	NA	8.7e-04
7	TCGA	Thyroid Carcinoma	0.0960	0.0440	4.6e-04	0.078	0.047	0.075	NA	0.077	4.9e-08	2.2e-05	8.8e-08	NA	5.6e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Fasting Glucose	15.1	18.1	39.3	3.1	-2.1	4.8	4.9	1.8	6.3	4.8
Loud music exposure frequency	12.3	13.5	18.4	4.3	-0.7	4.0	4.0	3.8	3.6	4.0
HbA1C	4.7	5.2	13.2	1.5	0.3	2.3	2.5	2.0	3.6	2.3
Eye problems/disorders: Diabetes related eye disease	4.6	5.1	9.6	-2.1	1.6	-2.3	-2.3	-1.9	-3.1	-2.3
Medication: Ramipril	4.4	5.7	8.3	-2.5	0.4	-2.4	-2.5	-2.5	-2.9	-2.4
Diabetes (father)	4.3	5.4	8.8	-2.4	0.6	-3.0	-2.8	-1.4	-2.1	-3.0
Guilty feelings	4.2	6.3	10.4	2.8	-2.4	2.2	2.4	3.2	2.2	2.2
Happiness	3.8	4.6	7.3	2.7	-1.1	2.3	2.4	2.3	1.2	2.3
Bipolar Disorder (2018)	3.6	5.7	7.0	2.3	-1.1	2.6	2.6	2.4	2.6	2.6
Diverticular disease/diverticulitis (self-reported)	3.6	4.3	5.7	-1.8	-0.1	-2.3	-2.3	-2.3	-2.4	-2.3
Nervous feelings	3.6	6.8	12.8	3.1	-2.1	2.5	2.7	3.6	1.0	2.5
Financial situation satisfaction	3.5	4.3	7.3	2.3	-2.7	1.8	2.1	2.5	0.5	1.8
Type 2 Diabetes (T2D) (2012)	3.2	3.7	5.0	-2.0	-0.7	-2.2	-2.0	-1.6	-2.1	-2.2
Neuroticism	3.2	7.7	20.1	2.6	-4.5	2.2	2.4	2.9	1.5	2.2
Breastfed as a baby	3.2	3.9	4.8	2.2	1.1	2.2	2.1	2.0	2.0	2.2
Exposure to tobacco smoke outside home	3.1	4.1	7.3	2.7	-0.8	2.2	2.3	2.2	1.2	2.2
Serious illness, injury or assault of a close relative in last 2 years	2.9	3.4	4.2	1.7	0.9	2.1	2.0	2.0	1.9	2.1
Suffer from ‘nerves’	2.8	4.4	8.2	2.4	-1.4	2.0	2.2	2.9	1.1	2.0
Qualifications: nursing, teaching	2.8	4.3	6.9	2.6	0.5	2.3	2.5	2.4	0.8	2.3
Neuroticism score	2.7	5.6	9.1	2.5	-3.0	2.0	2.3	2.9	1.3	2.0
Neuroticism (2016)	2.6	3.8	6.6	2.0	-2.2	1.6	1.8	2.6	1.5	1.6
Medication: Metformin	2.6	3.6	5.1	-2.2	1.6	-2.3	-2.2	-1.5	-0.9	-2.3
Medication: Allopurinol	2.5	3.4	12.4	1.3	-3.5	1.2	1.1	0.9	2.1	1.2
Medication: Gliclazide	2.5	2.8	4.5	-2.1	1.4	-2.1	-1.9	-0.7	-0.1	-2.1
Commuting to job workplace: Public transport	2.5	2.9	8.3	-1.6	1.2	-1.4	-1.6	-2.9	-1.2	-1.4
Noisy workplace	2.4	3.0	5.5	2.3	-1.5	1.7	1.9	1.9	0.4	1.7
Blood clot in the leg (DVT)	2.4	3.1	5.3	-1.7	0.8	-1.9	-1.8	-1.7	-2.3	-1.9
Diabetes (mother)	2.3	2.9	4.2	-1.8	1.8	-2.1	-1.9	-1.4	-0.0	-2.1
Bipolar Disorder (2011)	2.2	2.1	3.3	1.3	-1.1	1.4	1.4	1.5	1.8	1.4
Heart disease (mother)	2.2	2.7	4.8	1.5	-2.2	1.4	1.6	1.9	1.3	1.4
Deep venous thrombosis (DVT) (self-reported)	2.2	2.8	4.5	-1.6	0.4	-1.8	-1.8	-1.8	-2.1	-1.8
Tense / ‘highly strung’	2.1	3.5	4.5	2.0	-1.7	2.1	2.1	2.0	0.7	2.1
Bipolar Disorder or Schizophrenia	2.0	4.9	6.6	2.3	-0.3	2.5	2.6	2.4	1.8	2.5
Blood Platelet Count	2.0	23.0	29.4	-5.0	4.6	-5.2	-5.4	-4.9	-2.9	-5.2
Financial difficulties in last 2 years	2.0	2.6	4.8	1.5	-2.2	1.4	1.6	1.9	1.1	1.4
Had major operations	2.0	2.4	3.6	1.9	-0.2	1.9	1.8	1.5	1.0	1.9
Neuroticism (Nagel 2018)	1.9	4.4	8.4	2.2	-2.9	1.6	1.9	2.8	1.1	1.6
Birth weight	1.9	4.2	6.1	-1.5	2.5	-1.9	-2.1	-2.4	-1.7	-1.9
Number of children fathered	1.9	2.2	3.1	-1.3	-1.3	-1.4	-1.5	-1.8	-1.6	-1.4
Worry (Nagel 2018)	1.8	3.8	10.9	1.9	-3.3	1.3	1.6	2.5	0.3	1.3
LDL Cholesterol	1.8	2.8	3.5	1.9	1.2	1.8	1.7	1.5	1.9	1.8
Medication for pain relief, constipation, heartburn	1.8	3.1	4.8	1.6	0.5	2.1	2.0	2.2	1.1	2.1
Illnesses of siblings: Diabetes	1.8	2.2	4.6	-1.3	0.1	-2.1	-1.9	-0.7	-0.8	-2.1
Illnesses of father: None of the above (group 1)	1.8	2.2	3.7	1.6	-0.3	1.5	1.7	1.9	1.3	1.5
Basal cell carcinoma (self-reported)	1.8	2.2	3.2	1.8	-1.4	1.6	1.8	1.2	0.6	1.6
Medication: Paracetamol	1.7	2.9	5.0	-1.4	-0.1	-2.2	-2.1	-1.8	-0.8	-2.2
Medication: Amlodipine	1.7	2.4	4.4	1.6	-0.4	1.5	1.7	2.1	1.4	1.5
Health satisfaction	1.7	2.2	4.1	2.0	-0.4	1.5	1.5	1.8	1.0	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	4.4	-2.1	0.7	-1.5	-1.6	-1.3	-1.0	-1.5
Number of full sisters	1.7	2.1	4.0	-1.4	-0.2	-2.0	-1.6	0.0	-1.5	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	5.1	-1.7	1.7	-2.0	-2.0	-1.6	-2.3	-2.0
Coronary Artery Disease (CAD)	1.6	1.9	3.4	-1.5	1.2	-1.4	-1.4	-1.8	-0.5	-1.4
Number of live births	1.6	2.2	4.3	-2.1	-0.2	-1.8	-1.7	-1.3	-0.8	-1.8
Ever highly irritable/argumentative for 2 days	1.6	2.0	4.6	0.9	-2.1	1.4	1.3	1.5	0.8	1.4
Mood swings	1.6	2.9	4.2	2.1	-0.2	1.9	2.0	1.8	1.3	1.9
Lung FEV1/FVC ratio	1.5	7.8	10.2	-3.0	2.0	-2.6	-2.8	-3.2	-3.2	-2.6
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	2.5	1.4	-1.0	1.6	1.5	1.4	0.8	1.6
Alcohol intake versus 10 years previously	1.5	2.3	8.3	1.2	-2.9	1.3	1.4	0.7	0.5	1.3
Medication: Ibuprofen	1.5	1.8	2.7	1.2	-0.9	1.5	1.3	1.1	1.6	1.5
Overall health rating	1.5	3.1	6.4	2.5	-0.8	1.5	1.7	2.1	1.8	1.5
Medication: Paracetamol	1.5	2.4	4.5	-1.3	-0.6	-2.1	-2.0	-1.4	-0.1	-2.1
Fractured/broken bones in last 5 years	1.5	1.9	3.8	1.2	0.4	1.5	1.7	2.0	0.6	1.5
Supplements: Calcium	1.5	1.7	2.7	1.2	-1.6	1.3	1.4	1.6	0.2	1.3
Schizophrenia vs Biploar Disorder	1.4	1.8	3.6	-1.1	-0.4	-1.5	-1.4	-1.2	-1.9	-1.5
Blood White Count	1.4	10.3	41.5	4.1	-0.9	0.8	2.1	6.4	2.8	0.8
Height	1.4	27.9	97.4	-6.5	3.6	-2.4	-4.1	-9.9	-3.9	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	5.2	1.9	-0.8	1.6	1.8	2.0	2.3	1.6
Mouth/teeth dental problems	1.4	2.2	7.7	1.6	2.8	1.1	1.1	1.1	0.0	1.1
Gout (self-reported)	1.4	2.0	7.5	1.1	-2.7	0.9	0.9	0.9	1.3	0.9
Medication: Aspirin	1.4	1.8	2.6	-1.5	-1.1	-1.3	-1.2	-1.4	-1.6	-1.3
Friendships satisfaction	1.4	1.8	3.6	1.6	-1.9	1.1	1.3	1.3	0.5	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	2.5	1.2	-0.9	1.6	1.4	1.0	1.0	1.6
Peak expiratory flow (PEF)	1.3	2.9	8.5	-1.4	2.9	-0.4	-1.0	-2.4	-1.8	-0.4
Average weekly red wine intake	1.3	1.9	3.3	-1.4	1.2	-1.3	-1.4	-1.8	-1.0	-1.3
Medication: Bendroflumethiazide	1.3	2.0	4.1	-1.2	-0.2	-2.0	-1.7	-1.0	-0.6	-2.0
Reaction Time	1.2	2.3	5.4	-1.0	-2.3	-1.7	-1.4	-0.3	-1.5	-1.7
Mean Putamen Volume	1.2	1.3	2.8	1.5	-0.2	0.9	1.0	1.3	1.7	0.9
Mean time to correctly identify matches	1.2	2.4	5.6	-1.1	-2.4	-1.7	-1.4	-0.2	-1.4	-1.7
Alcohol intake frequency.	1.2	2.8	6.2	1.5	-2.5	1.2	1.4	1.9	1.7	1.2
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	2.2	-1.4	0.0	-1.4	-1.5	-1.2	-0.6	-1.4
Mouth/teeth dental problems: Mouth ulcers	1.2	1.8	2.6	-1.6	-1.5	-1.3	-1.4	-1.4	-0.8	-1.3
Medication: Aspirin	1.2	1.5	2.9	-1.4	-0.6	-1.0	-1.1	-1.7	-1.5	-1.0
Miserableness	1.2	2.1	9.6	1.0	-3.1	0.9	0.9	1.2	0.6	0.9
Triglycerides	1.1	1.8	3.1	1.8	-0.1	1.6	1.6	1.2	0.5	1.6
Ulcerative Colitis	1.1	1.6	7.5	-0.8	2.7	-0.4	-0.5	-1.2	-1.1	-0.4
Severe depression (siblings)	1.1	1.3	3.0	1.1	-1.3	0.9	1.1	1.7	0.3	0.9
Townsend deprivation index at recruitment	1.1	1.5	2.5	1.2	-1.0	1.1	1.3	1.4	1.6	1.1
Supplements: Glucosamine	1.1	1.4	3.1	1.0	1.8	1.3	1.2	0.5	0.8	1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	8.4	-1.6	1.6	0.4	-0.4	-2.9	-1.5	0.4
Alcohol drinker status: Never	1.1	1.3	2.1	-0.6	1.4	-1.4	-1.1	0.2	-1.2	-1.4
Average weekly spirits intake	1.0	1.2	1.9	1.2	-0.7	1.3	1.4	0.6	-0.8	1.3
Sensitivity / hurt feelings	1.0	1.8	7.1	0.8	-2.7	0.4	0.7	1.7	1.0	0.4
Average weekly fortified wine intake	1.0	1.1	1.9	1.4	-0.7	1.3	1.2	0.7	0.4	1.3
Hair/balding pattern: Pattern 2	1.0	1.3	1.8	1.1	-0.6	1.3	1.3	1.3	0.6	1.3
Qualifications: None of the above	1.0	2.2	4.3	-1.4	-0.8	-2.1	-1.9	-0.9	0.1	-2.1
Mouth/teeth dental problems: Dentures	1.0	1.6	5.3	-1.2	-2.3	-0.8	-0.9	-1.5	-0.4	-0.8
Standing height	1.0	9.9	38.2	-3.8	2.5	-0.4	-1.7	-6.2	-2.6	-0.4
Eye problems/disorders: None of the above	1.0	1.2	3.2	1.4	0.1	0.6	0.8	1.3	1.8	0.6
Heart disease (siblings)	1.0	1.2	3.0	1.3	-0.9	0.6	1.0	1.7	-1.0	0.6
Depressed Affect (Nagel 2018)	0.9	1.9	2.8	1.7	-1.5	1.4	1.4	1.6	0.6	1.4
Major Depression (MDD)	0.9	1.1	5.4	-0.1	-2.3	-0.3	-0.1	0.3	-1.4	-0.3
Taking other prescription medications	0.9	1.4	2.5	1.6	-1.2	0.6	0.9	1.3	1.6	0.6
Chronic bronchitis/emphysema (father)	0.9	1.1	1.6	-1.2	-0.9	-1.0	-1.0	-1.3	-0.8	-1.0
Trunk fat-free mass	0.9	5.1	18.4	-2.8	2.5	-0.0	-1.1	-4.3	-1.4	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.9	7.5	-1.3	2.5	-0.5	-1.1	-2.7	-1.6	-0.5
Trunk predicted mass	0.9	5.3	19.0	-2.9	2.5	-0.1	-1.1	-4.4	-1.5	-0.1
Exposure to tobacco smoke at home	0.9	1.0	1.5	1.1	-0.9	1.2	1.1	0.7	0.8	1.2
Worry too long after embarrassment	0.9	1.4	4.9	1.1	-2.2	0.7	0.9	1.4	-0.2	0.7
Age at first live birth	0.9	1.6	3.7	-1.1	1.5	-0.6	-0.8	-1.6	-1.9	-0.6
Family relationship satisfaction	0.9	1.1	2.3	1.3	-1.5	1.0	0.9	0.4	1.0	1.0
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.4	1.0	-0.2	0.8	1.0	1.2	1.6	0.8
Breast cancer (self-reported)	0.9	1.1	2.9	-1.0	1.3	-0.3	-0.5	-1.2	-1.7	-0.3
Hearing aid user	0.9	1.1	2.2	-0.7	1.2	-1.0	-1.0	-1.5	-0.6	-1.0
Age started oral contraceptive pill	0.9	1.2	4.1	0.8	2.0	0.8	0.8	0.7	1.0	0.8
Medication: Omeprazole (e.g. Zanprol)	0.9	1.2	1.9	-1.2	-0.6	-1.4	-1.3	-0.9	0.3	-1.4
Alzheimer’s Disease (in mother)	0.8	0.9	2.4	0.9	-1.2	0.4	0.5	1.1	1.6	0.4
Pack years adult smoking proportion	0.8	1.2	7.5	-0.0	-2.7	0.2	0.2	0.5	-0.6	0.2
Maternal smoking around birth	0.8	1.1	2.0	0.3	-1.4	1.4	1.1	0.6	0.4	1.4
Age when periods started (menarche)	0.8	2.0	4.7	-1.7	0.3	-1.0	-1.4	-2.2	-1.5	-1.0
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	1.6	0.8	-0.1	1.3	1.1	0.7	1.1	1.3
Multivitamins +/- minerals	0.8	1.0	1.8	1.1	0.5	1.4	1.2	0.8	-0.1	1.4
Father’s age at death	0.8	1.1	2.6	-0.9	1.6	-0.7	-0.7	-0.9	-1.4	-0.7
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	2.4	-1.3	1.1	-1.6	-1.5	-1.1	-0.1	-1.6
Mother’s age at death	0.8	1.0	1.5	-0.6	1.1	-1.0	-1.2	-1.2	-0.8	-1.0
High cholesterol (Self-reported)	0.8	1.4	2.6	-0.6	-1.5	-1.6	-1.1	0.2	0.6	-1.6
Pack years of smoking	0.8	1.2	7.6	-0.3	-2.8	-0.1	-0.1	0.2	-0.6	-0.1
Alzheimer’s Disease (in father)	0.7	0.8	2.6	-0.6	-0.7	-0.8	-0.8	-0.2	-1.6	-0.8
Schizophrenia (2014)	0.7	1.6	3.0	1.7	-0.1	1.4	1.4	1.6	-0.0	1.4
Hand grip strength (right)	0.7	1.9	5.6	-1.4	1.3	-0.2	-0.7	-2.4	-1.9	-0.2
Qualifications: CSEs or equivalent	0.7	0.9	1.9	1.2	-0.3	1.0	1.1	1.4	0.1	1.0
Past tobacco smoking	0.7	1.3	5.0	0.9	-2.2	-0.1	0.3	1.6	0.8	-0.1
Hearing difficulty/problems with background noise	0.7	1.1	2.2	1.1	0.2	1.1	1.2	1.5	0.2	1.1
Pulse rate	0.7	1.1	2.6	1.0	0.1	0.9	1.0	1.6	1.2	0.9
Pulse wave Arterial Stiffness index	0.7	0.8	3.0	0.0	-1.7	-0.3	-0.2	0.5	-1.6	-0.3
Number of full brothers	0.7	0.9	4.5	-0.7	2.1	-0.5	-0.5	-0.6	-0.0	-0.5
Pulse wave peak to peak time	0.7	0.9	3.3	-0.3	1.8	0.3	0.0	-0.9	1.4	0.3
Whole body fat-free mass	0.7	3.9	13.8	-2.4	2.4	0.2	-0.8	-3.7	-1.0	0.2
Ever had bowel cancer screening	0.7	0.8	1.9	-0.5	0.1	-1.0	-1.0	-0.8	-1.4	-1.0
Mineral and other dietary supplements	0.7	0.9	1.8	-0.7	-1.0	-1.3	-1.1	-0.3	-0.1	-1.3
Whole body water mass	0.7	3.8	13.5	-2.4	2.4	0.2	-0.8	-3.7	-1.0	0.2
Arm predicted mass (left)	0.7	3.6	13.3	-2.3	2.2	0.1	-0.8	-3.6	-1.0	0.1
Prostate Cancer	0.6	0.9	1.9	0.9	0.7	0.9	1.0	0.3	-1.4	0.9
Lupus	0.6	0.9	3.2	1.0	-0.8	0.1	0.4	1.8	1.2	0.1
Cardiovascular Disease	0.6	1.8	6.9	1.3	-2.6	0.4	0.8	1.6	0.8	0.4
Systolic blood pressure, automated reading	0.6	1.7	3.2	0.9	-1.0	1.3	1.4	1.2	1.8	1.3
Serious illness, injury or assault to yourself	0.6	0.7	2.8	0.6	1.7	0.7	0.7	0.6	0.2	0.7
Medication: Levothyroxine sodium	0.6	1.1	1.6	-1.1	0.9	-1.3	-1.2	-0.9	0.4	-1.3
Sitting height	0.6	4.6	15.6	-2.4	3.1	0.5	-0.6	-4.0	-0.4	0.5
Worrier / anxious feelings	0.6	1.1	3.9	0.9	-2.0	-0.0	0.4	1.7	-0.3	-0.0
Hair/balding pattern: Pattern 3	0.6	0.8	4.1	0.5	-0.1	0.7	0.6	0.3	2.0	0.7
Hair/balding pattern: Pattern 4	0.6	1.4	3.2	-1.1	-1.2	-1.3	-1.0	-0.0	-1.8	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	3.4	-0.7	-1.9	-0.4	-0.5	-0.0	0.6	-0.4
Medication: Blood pressure	0.6	1.1	3.0	1.1	-1.3	0.5	0.9	1.7	0.8	0.5
Chest pain or discomfort	0.6	0.8	1.9	0.8	-0.9	0.7	0.8	1.4	1.0	0.7
Leg pain on walking	0.6	0.7	1.9	1.0	0.7	0.6	0.7	1.4	0.7	0.6
Illnesses of father: Heart disease	0.6	0.8	1.8	0.9	0.8	1.0	0.8	0.4	1.3	1.0
Long-standing illness, disability or infirmity	0.6	1.0	1.5	1.2	-0.5	0.9	1.1	1.1	1.0	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	3.4	-0.5	0.5	-0.0	-0.4	-1.8	-0.3	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.2	-0.3	-0.1	-1.1	-1.0	-0.2	-1.0	-1.1
Osteoporosis (self-reported)	0.6	0.7	1.4	-0.5	-1.2	-1.0	-0.8	0.1	0.9	-1.0
Arm fat-free mass (left)	0.6	2.9	11.3	-2.0	2.0	0.5	-0.5	-3.4	-0.5	0.5
Ever depressed for a whole week	0.6	0.7	4.2	0.6	-2.0	0.2	0.2	0.7	-0.1	0.2
Depression (Nagel 2018)	0.5	0.7	2.8	0.8	-1.7	0.0	0.2	1.1	-0.1	0.0
Schizophrenia (2018)	0.5	1.0	1.4	1.2	0.5	1.2	1.2	1.2	0.2	1.2
Crohns Disease (2017)	0.5	1.0	2.6	0.2	-1.6	0.6	0.7	1.2	1.3	0.6
Ulcerative Colitis (UC)	0.5	0.9	1.8	0.9	1.4	1.0	1.0	0.6	0.4	1.0
Age at First Birth	0.5	0.7	1.7	-0.9	-0.3	-0.8	-1.0	-1.3	0.2	-0.8
Systolic Blood Pressure	0.5	2.4	6.8	0.9	-2.6	1.4	1.5	1.2	1.3	1.4
Chronotype (morning person)	0.5	1.1	3.7	0.4	-1.9	0.2	0.4	1.1	1.5	0.2
Angina	0.5	0.7	1.1	1.0	-1.0	0.5	0.7	0.9	1.0	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.5	1.0	-0.5	1.0	1.1	1.0	1.6	1.0
Had menopause	0.5	0.7	2.8	0.8	1.7	0.5	0.5	0.6	-0.1	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.6	1.1	-0.3	0.7	0.9	1.3	0.9	0.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	5.0	-1.0	1.9	0.0	-0.5	-2.2	-1.4	0.0
Medication: Cholesterol lowering	0.5	0.8	1.6	-0.7	-0.1	-1.2	-0.9	0.0	1.0	-1.2
Lung cancer (father)	0.5	0.6	1.5	0.9	-0.7	0.7	0.7	0.4	1.2	0.7
Length of working week for main job	0.5	0.6	1.7	0.6	-0.2	0.5	0.6	1.1	1.3	0.5
Forced vital capacity (FVC), Best measure	0.5	2.0	5.9	-1.2	2.2	-0.3	-0.8	-2.4	-1.1	-0.3
Arm fat-free mass (right)	0.5	2.8	8.8	-1.6	2.6	0.7	-0.2	-3.0	-0.4	0.7
Angina (self-reported)	0.5	0.6	1.0	1.0	-1.0	0.5	0.7	0.8	0.9	0.5
Migraine (self-reported)	0.5	0.7	0.8	-0.7	0.7	-0.9	-0.9	-0.8	-0.9	-0.9
Arm predicted mass (right)	0.5	2.3	7.6	-1.5	2.3	0.8	-0.0	-2.8	-0.2	0.8
Commuting to job workplace: Car/motor vehicle	0.5	0.5	2.4	0.5	-0.7	0.2	0.3	1.6	0.5	0.2
Smoking status: Previous	0.5	0.8	3.4	-0.7	1.8	-0.1	-0.3	-1.2	-0.3	-0.1
Loneliness, isolation	0.5	0.7	1.9	0.9	-1.4	0.2	0.4	1.2	0.7	0.2
Diabetes diagnosed by doctor	0.5	0.8	1.5	-1.2	0.5	-1.1	-1.0	-0.2	-0.4	-1.1
Commuting to job workplace: Walk	0.5	0.5	1.7	0.1	1.3	0.2	0.1	-1.1	-0.7	0.2
Ever smoked	0.5	0.8	3.5	-0.4	1.9	0.4	0.1	-1.3	-0.4	0.4
Basal metabolic rate	0.5	2.6	9.7	-1.9	2.0	0.4	-0.4	-3.1	-0.7	0.4
Number of operations (self-reported)	0.5	0.8	1.9	0.6	1.4	0.9	0.7	0.4	0.9	0.9
Breast Cancer	0.4	1.0	2.1	-1.4	0.2	-0.6	-0.8	-1.4	-1.3	-0.6
HDL Cholesterol	0.4	0.7	1.1	-0.9	0.6	-1.0	-0.9	-0.2	-0.9	-1.0
Allergy or Eczema	0.4	1.0	2.6	1.1	-1.6	0.9	0.9	0.8	0.8	0.9
Hypothyroidism (self reported)	0.4	0.8	1.3	-0.9	0.5	-1.2	-1.1	-0.9	0.1	-1.2
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.8	0.7	-1.7	-0.1	0.0	0.4	-0.6	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.7	0.1	-1.3	-0.4	-0.3	0.6	-1.0	-0.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.7	0.6	-0.3	0.8	0.8	0.9	0.4	0.8
Medication: Atenolol	0.4	0.5	1.7	0.3	0.4	0.4	0.5	1.0	1.3	0.4
High blood pressure (mother)	0.4	0.5	0.8	0.6	0.7	0.9	0.8	0.3	0.7	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.6	0.8	-1.6	0.5	0.6	0.2	0.1	0.5
Had other major operations	0.4	0.5	0.8	0.7	-0.6	0.8	0.8	0.6	0.9	0.8
Medication: Simvastatin	0.4	0.7	1.8	-0.2	-1.2	-0.6	-0.2	0.6	1.4	-0.6
Depression (self-reported)	0.4	0.5	1.7	0.4	-1.3	-0.6	-0.3	0.9	0.1	-0.6
Illnesses of mother	0.4	0.5	0.7	-0.6	-0.8	-0.8	-0.8	-0.8	-0.5	-0.8
Pulse wave reflection index	0.4	0.5	1.7	0.2	-1.2	0.1	0.2	0.6	-1.3	0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.0	0.7	-0.9	1.0	0.8	0.6	-0.4	1.0
Comparative body size at age 10	0.4	1.1	3.9	1.2	-1.0	0.2	0.5	2.0	1.1	0.2
Age at last live birth	0.4	0.6	1.1	-1.0	0.8	-0.4	-0.5	-1.0	-1.0	-0.4
Hypertension (Self-reported)	0.4	1.1	2.1	1.4	-0.6	1.0	1.1	1.4	0.2	1.0
Leg fat-free mass (right)	0.4	2.3	8.0	-1.9	2.0	0.3	-0.4	-2.8	-0.6	0.3
Leg predicted mass (right)	0.4	2.3	8.0	-1.9	2.0	0.3	-0.4	-2.8	-0.6	0.3
Eye problems/disorders: Glaucoma	0.4	0.5	1.0	-0.8	-0.8	-0.5	-0.6	-1.0	-0.6	-0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.4	0.3	1.5	0.6	0.3	-0.4	-0.4	0.6
Irritability	0.4	0.7	1.3	0.6	0.7	0.9	0.9	0.6	1.1	0.9
Risk taking	0.4	0.5	1.6	-0.5	0.2	-0.2	-0.4	-1.2	-1.3	-0.2
Unable to work because of sickness or disability	0.4	0.5	1.3	0.7	-1.1	0.2	0.5	1.0	0.8	0.2
Alcohol drinker status: Previous	0.4	0.5	1.0	0.8	-0.7	0.3	0.4	1.0	1.0	0.3
Irritable Bowel Disease (IBD)	0.3	0.7	1.5	0.7	0.0	0.8	0.9	1.2	1.0	0.8
Waist Hip Ratio (WHR)	0.3	1.2	2.5	-0.2	-1.1	-1.6	-1.3	0.4	-0.0	-1.6
Hand grip strength (left)	0.3	0.8	1.8	-0.2	0.6	0.9	0.4	-1.3	-1.2	0.9
Number of treatments/medications taken	0.3	0.6	1.4	0.9	-0.8	0.1	0.5	1.0	1.2	0.1
Relative age of first facial hair	0.3	0.6	1.1	0.7	0.9	1.0	0.9	0.2	-0.1	1.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.0	-0.7	-0.2	-0.5	-0.5	-0.9	-1.0	-0.5
Ever had hysterectomy (womb removed)	0.3	0.3	0.8	-0.3	-0.9	-0.6	-0.6	-0.3	-0.5	-0.6
Medication: Co-codamol	0.3	0.4	0.7	-0.3	0.8	-0.8	-0.6	-0.5	0.5	-0.8
Leg fat-free mass (left)	0.3	1.8	6.5	-1.6	1.8	0.5	-0.2	-2.5	-0.4	0.5
Fed-up feelings	0.3	0.6	1.8	0.8	-1.3	0.2	0.4	1.0	0.5	0.2
Relative age voice broke	0.3	0.4	0.9	0.6	-0.2	1.0	0.6	0.3	0.2	1.0
Leg predicted mass (left)	0.3	1.8	6.2	-1.5	1.8	0.5	-0.2	-2.5	-0.4	0.5
Forced vital capacity (FVC)	0.3	1.1	3.4	-0.7	1.8	0.4	-0.1	-1.8	-0.8	0.4
Pain all over the body in last month	0.3	0.4	1.3	-0.5	1.1	-0.5	-0.5	-0.4	-0.4	-0.5
Diabetes (self-reported)	0.3	0.5	0.9	-1.0	0.9	-0.8	-0.8	-0.4	-0.3	-0.8
Illnesses of siblings	0.3	0.4	0.8	0.3	0.2	0.9	0.5	-0.7	0.5	0.9
Asthma	0.3	0.6	1.8	0.1	-1.2	-0.3	-0.2	0.6	1.4	-0.3
Prospective memory result	0.3	0.4	1.4	-0.2	1.2	-0.4	-0.5	-0.3	0.8	-0.4
Birth weight of first child	0.3	0.5	1.7	0.1	0.6	0.8	0.7	0.3	1.3	0.8
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.8	-0.7	-0.7	-0.9	-0.8	0.1	0.0	-0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.1	0.6	-0.6	0.3	0.4	0.8	1.1	0.3
Leg fat percentage (right)	0.3	1.1	2.3	1.3	-1.1	0.6	0.8	1.5	1.2	0.6
Medication: Omeprazole	0.3	0.3	0.7	-0.4	-0.5	-0.6	-0.5	0.1	0.9	-0.6
Supplements: Vitamin C	0.3	0.4	0.6	0.3	0.7	0.8	0.7	0.4	0.5	0.8
Eye problems/disorders: Cataract	0.3	0.4	0.9	-0.9	-0.2	-0.4	-0.5	-0.4	-0.9	-0.4
Asthma (self-reported)	0.3	0.5	2.0	0.2	-1.1	-0.3	-0.2	0.6	1.4	-0.3
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.5	0.6	-0.6	0.4	0.6	0.7	-0.6	0.4
Leg fat percentage (left)	0.3	1.2	2.3	1.4	-0.9	0.7	0.9	1.5	1.3	0.7
Cholesterol lowering medication	0.3	0.4	1.8	0.3	-1.4	-0.5	-0.2	0.6	0.5	-0.5
Pain experienced in last month	0.3	0.6	1.1	-1.0	-1.1	-0.8	-0.7	0.0	-0.2	-0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.6	0.8	0.5	0.7	0.8	0.4	0.0	0.7
Intelligence (Savage-Jansen 2018)	0.2	0.6	3.6	0.2	0.1	0.6	0.5	-0.0	1.9	0.6
Body Mass Index (BMI) (2010)	0.2	0.2	0.9	0.2	-0.2	-0.3	0.1	1.0	0.6	-0.3
Blood Eosinophil Count	0.2	1.6	4.0	0.6	-2.0	-0.8	-0.3	1.7	1.5	-0.8
Blood Red Count	0.2	1.9	3.5	1.7	0.2	1.3	1.3	1.9	-1.3	1.3
BMI	0.2	1.0	1.8	1.4	0.6	1.2	1.1	0.9	0.4	1.2
Smoking Status	0.2	0.5	1.4	-0.8	1.1	-0.0	-0.2	-1.2	-0.2	-0.0
Respiratory disease	0.2	0.4	1.8	-0.0	-1.4	-0.3	-0.4	-0.4	0.7	-0.3
Tanning	0.2	1.9	3.9	-2.0	0.8	-1.3	-1.5	-1.6	-0.9	-1.3
Medication for hormone replacement therapy	0.2	0.2	1.0	0.2	-0.4	-0.4	-0.3	-0.2	1.0	-0.4
Vitamin and mineral supplements	0.2	0.3	0.7	-0.5	-0.8	-0.6	-0.4	-0.1	0.5	-0.6
High blood pressure	0.2	0.6	1.2	1.1	-0.4	0.6	0.7	1.1	0.1	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.8	0.6	-0.9	0.3	0.4	0.5	0.7	0.3
Alcohol usually taken with meals	0.2	0.3	0.4	-0.6	0.5	-0.5	-0.6	-0.6	-0.6	-0.5
Heart attack	0.2	0.3	0.6	0.8	0.4	0.6	0.7	0.4	0.1	0.6
Allergy	0.2	0.5	3.2	-0.1	1.8	0.2	0.1	-0.2	-0.7	0.2
Impedance of arm (right)	0.2	0.8	1.6	-0.1	-0.9	-1.1	-0.8	-0.2	-1.3	-1.1
Time employed in main current job	0.2	0.2	0.5	-0.4	-0.7	-0.4	-0.2	0.6	0.6	-0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.5	-0.3	-0.5	-0.3	-0.4	-0.5	-1.2	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	1.1	1.0	0.5	0.1	0.2	0.4	0.3	0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.8	0.0	0.5	0.7	0.4	-0.4	-0.9	0.7
Glaucoma (self-reported)	0.2	0.3	0.5	-0.6	0.5	-0.6	-0.6	-0.7	-0.1	-0.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	-0.4	0.2	0.6	0.5	-0.5	-0.3	0.6
High blood pressure (siblings)	0.2	0.4	1.7	0.4	0.4	0.3	0.4	1.3	0.4	0.3
Body fat percentage	0.2	0.6	1.4	0.9	-0.7	0.2	0.5	1.2	1.1	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.2	1.1	0.0	-0.0	0.3	0.9	-0.2	-0.0
Wheeze or whistling in the chest in last year	0.2	0.4	0.7	0.8	-0.1	0.3	0.5	0.8	0.9	0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.6	-0.1	0.1	0.4	0.4	0.2	1.3	0.4
Emphysema/chronic bronchitis	0.2	0.2	1.1	-0.4	-1.1	0.1	-0.1	-0.3	-0.0	0.1
Neck or shoulder pain in last month	0.2	0.3	1.5	0.1	1.2	-0.1	0.0	-0.4	-0.2	-0.1
Medication: Seretide 50 evohaler	0.2	0.2	0.4	0.3	-0.6	0.3	0.3	0.5	0.6	0.3
Pulse rate, automated reading	0.2	0.7	1.8	1.1	0.6	0.3	0.6	1.3	0.8	0.3
Knee pain experienced in last month	0.2	0.3	1.0	0.4	0.1	0.2	0.3	0.6	-1.0	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	-0.5	-0.4	-0.6	-0.4	-0.1	0.3	-0.6
Arm fat percentage (left)	0.2	0.7	2.3	1.0	-0.3	0.2	0.5	1.5	1.1	0.2
Back pain experienced in last month	0.2	0.3	0.7	0.0	0.9	-0.4	-0.4	-0.8	0.3	-0.4
Osteoarthritis (self-reported)	0.2	0.3	0.6	-0.1	0.3	-0.7	-0.7	0.0	-0.6	-0.7
Number of self-reported non-cancer illnesses	0.2	0.4	1.3	0.9	-1.1	0.1	0.3	0.8	0.1	0.1
Average weekly champagne plus white wine intake	0.2	0.2	0.4	-0.4	0.1	-0.4	-0.6	-0.5	-0.6	-0.4
Ever taken oral contraceptive pill	0.2	0.2	0.6	-0.1	-0.2	0.4	0.2	-0.8	-0.7	0.4
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	0.5	-0.6	0.4	0.3	0.4	-0.3	0.4
Diastolic blood pressure, automated reading	0.2	0.6	1.9	-0.5	-0.6	-0.5	-0.6	-0.8	-1.4	-0.5
Commuting to job workplace: Cycle	0.2	0.3	0.9	-0.9	0.1	-0.0	-0.2	-0.8	0.5	-0.0
Myopia	0.2	0.3	0.6	-0.8	0.3	-0.6	-0.5	-0.6	-0.7	-0.6
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.4	-1.2	0.7	-0.5	-0.7	-0.9	-0.1	-0.5
Alzheimer’s Disease (including proxy)	0.1	0.1	0.5	0.2	-0.7	-0.3	-0.2	0.4	0.1	-0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.8	-0.1	-0.9	0.4	0.3	-0.2	0.9	0.4
Ovarian Cancer	0.1	0.1	0.7	-0.1	0.3	-0.2	-0.1	-0.3	-0.8	-0.2
Crohns Disease (2012)	0.1	0.2	0.7	-0.8	-0.0	-0.4	-0.5	0.1	-0.4	-0.4
Primary Biliary Cirrhosis	0.1	0.1	0.3	0.1	0.4	0.5	0.4	-0.4	-0.3	0.5
Rheumatoid Arthritis	0.1	0.2	0.7	-0.3	0.5	0.1	-0.1	-0.8	0.1	0.1
Lung FVC	0.1	0.7	3.0	0.9	1.7	0.1	0.2	0.9	-0.7	0.1
Hair Pigment	0.1	2.9	4.7	1.9	-0.1	2.2	2.1	1.4	1.1	2.2
Hearing difficulty/problems: Yes	0.1	0.2	1.3	0.1	0.2	-0.1	-0.0	0.2	-1.1	-0.1
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	0.1	0.4	-0.2	-0.2	0.1	0.5	-0.2
Supplements: Zinc	0.1	0.1	0.4	-0.3	0.6	0.0	0.0	0.2	-0.6	0.0
Impedance of leg (right)	0.1	0.7	2.9	1.0	-1.7	0.3	0.4	0.9	-0.1	0.3
Trunk fat percentage	0.1	0.4	1.0	0.7	-0.3	0.2	0.4	0.9	1.0	0.2
Current tobacco smoking	0.1	0.1	0.3	0.2	-0.3	0.2	0.3	0.2	0.6	0.2
Stomach or abdominal pain in last month	0.1	0.2	0.3	0.5	-0.6	0.5	0.4	-0.0	-0.1	0.5
Body mass index (BMI)	0.1	0.4	1.2	0.6	-0.3	0.4	0.5	0.9	1.1	0.4
Impedance of leg (left)	0.1	0.4	1.5	0.8	-1.2	0.1	0.3	0.5	-0.3	0.1
Number of incorrect matches in round	0.1	0.2	0.5	0.5	-0.1	0.2	0.4	0.5	-0.7	0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.3	-0.0	0.0	-0.5	-0.6	-0.2	-0.5	-0.5
Weight	0.1	0.7	2.9	-1.0	0.8	0.4	-0.1	-1.7	-0.1	0.4
Arm fat percentage (right)	0.1	0.3	0.7	0.5	-0.4	-0.3	-0.1	0.8	0.8	-0.3
Hip circumference	0.1	0.6	1.5	0.1	0.4	1.2	0.9	-0.3	0.5	1.2
Falls in the last year	0.1	0.1	0.6	-0.1	-0.3	-0.1	-0.1	0.2	-0.8	-0.1
Medication: Lansoprazole	0.1	0.1	0.8	0.3	0.0	0.1	0.3	0.1	0.9	0.1
Impedance of arm (left)	0.1	0.3	0.5	0.5	-0.5	-0.6	-0.2	0.6	-0.7	-0.6
Headache pain in last month	0.1	0.2	1.1	-0.1	1.1	-0.2	-0.3	-0.3	-0.2	-0.2
Shortness of breath walking on level ground	0.1	0.1	0.4	0.3	0.1	0.0	0.1	-0.0	-0.6	0.0
Qualifications: College or University degree	0.1	0.4	0.8	0.6	0.6	0.9	0.8	-0.3	0.0	0.9
Leg fat mass (right)	0.1	0.5	0.8	0.7	-0.4	0.8	0.7	0.5	0.9	0.8
Comparative height size at age 10	0.1	0.7	1.1	-0.1	0.9	1.0	0.7	-1.0	-0.8	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.5	-0.2	0.4	0.1	0.1	-0.5	-0.7	0.1
Medication for cholesterol	0.1	0.2	0.3	-0.2	0.2	0.6	0.4	0.1	0.4	0.6
Wears glasses or contact lenses	0.1	0.1	0.3	0.4	-0.3	0.0	0.0	-0.0	-0.5	0.0
Medication: Blood pressure	0.1	0.2	1.1	-0.3	-0.0	-0.3	-0.3	-0.4	-1.0	-0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.3	0.3	-0.0	0.0	0.3	-0.5	-0.0
Medication: Lisinopril	0.1	0.1	0.2	-0.3	-0.4	-0.5	-0.2	0.4	-0.3	-0.5
Average weekly beer plus cider intake	0.1	0.2	0.4	0.1	-0.7	0.4	0.4	-0.4	0.1	0.4
Impedance of whole body	0.1	0.4	1.6	0.5	-1.3	-0.4	-0.1	0.5	-0.5	-0.4
Leg fat mass (left)	0.1	0.5	0.8	0.7	-0.3	0.8	0.7	0.4	0.9	0.8
Heel T-Score	0.0	0.2	0.7	0.3	0.8	0.1	0.2	-0.0	0.7	0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.4	-0.1	0.6	-0.2	-0.1	0.3	-0.2	-0.2
Trunk fat mass	0.0	0.1	0.3	-0.1	0.2	0.1	0.0	-0.3	0.6	0.1
Waist circumference	0.0	0.1	0.3	0.1	-0.2	0.2	0.1	0.1	0.6	0.2
Fluid intelligence score	0.0	0.1	0.3	-0.5	-0.3	-0.0	-0.1	-0.4	-0.4	-0.0
Arm fat mass (right)	0.0	0.1	0.3	-0.2	0.5	-0.1	-0.2	-0.4	0.5	-0.1
Whole body fat mass	0.0	0.1	0.3	0.2	0.2	0.3	0.2	0.1	0.5	0.3
Smoking status: Current	0.0	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	-0.0	0.1
Arm fat mass (left)	0.0	0.1	0.6	0.0	0.5	0.2	0.2	-0.1	0.8	0.2
Medication: Atorvastatin	0.0	0.0	0.2	0.5	-0.1	0.0	-0.1	0.3	-0.1	0.0
Illnesses of father: High blood pressure	0.0	0.1	0.2	0.1	-0.2	0.0	-0.1	-0.4	-0.4	0.0

Hub : Genes

SPC25

Models

Trait associations