Hub : Traits :

Fasting Glucose

97 significantly associated models · 35 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 26592429 29260106 18 6 7.5e-21 4.2e-25 0.0e+00 -4930 AC074117.10 EIF2B4 KHK NRBP1
2 2 168949234 170419444 1 2 5.5e-11 2.6e-99 2.8e-89 10 NOSTRIN
3 4 75874984 77296600 1 1 4.3e-12 4.1e-03 8.9e-03 17 G3BP2
4 6 3327407 4763028 1 1 1.7e-09 2.1e-03 1.0e-02 30 PRPF4B
5 7 43302684 44814172 2 2 3.4e-09 3.5e-53 1.6e-40 25 AC004985.12 POLM
6 7 91922541 93297506 1 1 1.3e-10 1.2e-03 7.7e-04 -8 RN7SL7P
7 9 129459985 130862713 1 1 7.6e-08 4.0e-03 8.3e-01 99 SLC2A8
8 11 44974800 46370767 1 1 3.2e-07 3.8e-13 2.3e-09 32 RP11-495O11.1
9 11 46570859 48028343 3 2 4.0e-12 1.3e-12 2.2e-01 97 MADD NR1H3
10 11 60839578 62346131 5 1 4.9e-11 3.8e-11 1.4e-03 77 FADS1
11 16 34516075 35174439 1 1 6.8e-09 3.9e-02 5.6e-02 15 AC116553.1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 1.50 1 0 0.0 0.00 1.0000 NR1H3
Crohns Disease (2017) 2.47 3 1 3.0 0.00 1.0000 AC074117.10 FADS1 NRBP1
Irritable Bowel Disease (IBD) 2.10 3 1 3.0 0.00 1.0000 AC074117.10 FADS1 NRBP1
Verbal and Numeric Reasoning (VNR) 1.81 3 0 0.0 0.49 0.5113 FADS1 KHK RP11-495O11.1
Breast Cancer 1.06 1 0 0.0 0.00 1.0000 NR1H3
Crohns Disease (2012) 1.66 1 0 0.0 0.00 1.0000 FADS1
HbA1C 4.37 2 1 3.0 0.00 1.0000 AC004985.12 PRPF4B
HDL Cholesterol 4.78 3 1 3.0 0.00 1.0000 FADS1 NR1H3 RP11-495O11.1
LDL Cholesterol 4.15 1 1 3.0 0.00 1.0000 FADS1
Neuroticism 0.96 1 0 0.0 0.00 1.0000 NR1H3
Primary Biliary Cirrhosis 1.52 1 0 0.0 0.00 1.0000 NRBP1
Triglycerides 24.88 5 4 12.1 -0.95 0.0134 AC074117.10 EIF2B4 FADS1 KHK NRBP1
Blood Eosinophil Count 1.38 2 2 6.1 0.00 1.0000 FADS1 NOSTRIN
Blood Platelet Count 7.68 6 6 18.2 -0.87 0.0047 AC074117.10 EIF2B4 FADS1 KHK NRBP1 SLC2A8
Blood Red Count 1.70 2 1 3.0 0.00 1.0000 FADS1 KHK
Blood White Count 6.26 5 5 15.2 -0.76 0.0482 AC074117.10 EIF2B4 FADS1 NOSTRIN NRBP1
Heel T-Score 1.07 2 2 6.1 0.00 1.0000 FADS1 NR1H3
BMI 0.81 1 1 3.0 0.00 1.0000 MADD
Height 2.02 6 6 18.2 0.93 0.0010 AC074117.10 EIF2B4 FADS1 MADD NOSTRIN NRBP1
Waist Hip Ratio (WHR) 0.91 1 0 0.0 0.00 1.0000 NOSTRIN
Systolic Blood Pressure 2.23 4 1 3.0 -0.95 0.0542 AC074117.10 EIF2B4 NR1H3 NRBP1
Allergy or Eczema 1.56 2 0 0.0 0.00 1.0000 AC074117.10 NRBP1
Cardiovascular Disease 3.63 5 3 9.1 -0.97 0.0059 AC074117.10 EIF2B4 KHK NR1H3 NRBP1
Hypothyroidism (self reported) 1.64 1 1 3.0 0.00 1.0000 FADS1
Respiratory disease 1.88 1 1 3.0 0.00 1.0000 FADS1
Type 2 Diabetes (T2D) 3.33 2 2 6.1 0.00 1.0000 AC074117.10 NRBP1
Neuroticism 1.55 1 1 3.0 0.00 1.0000 NR1H3
Hair Pigment 0.39 4 2 6.1 -0.82 0.0918 AC074117.10 FADS1 NR1H3 NRBP1
Tanning 0.45 2 2 6.1 0.00 1.0000 AC074117.10 NRBP1
Hand grip strength (left) 1.49 1 0 0.0 0.00 1.0000 NOSTRIN
Number of treatments/medications taken 3.01 3 0 0.0 0.58 0.4165 AC074117.10 FADS1 NRBP1
Relative age of first facial hair 0.91 2 0 0.0 0.00 1.0000 AC074117.10 NRBP1
Systolic blood pressure, automated reading 1.34 1 1 3.0 0.00 1.0000 NR1H3
Medication: Metformin 2.54 2 0 0.0 0.00 1.0000 AC074117.10 NRBP1
Diabetes (father) 2.16 2 0 0.0 0.00 1.0000 AC074117.10 NRBP1
Impedance of leg (right) 1.07 4 0 0.0 0.99 0.0136 AC074117.10 EIF2B4 MADD NRBP1
Leg fat-free mass (left) 2.44 6 4 12.1 -0.95 0.0031 AC074117.10 EIF2B4 MADD NOSTRIN NR1H3 NRBP1
Trunk fat percentage 1.20 2 1 3.0 0.00 1.0000 KHK MADD
Hand grip strength (right) 1.35 1 0 0.0 0.00 1.0000 NOSTRIN
Fed-up feelings 1.32 1 0 0.0 0.00 1.0000 NR1H3
Age when periods started (menarche) 1.45 1 1 3.0 0.00 1.0000 MADD
Heel bone mineral density (BMD) T-score, automated (left) 1.57 2 0 0.0 0.00 1.0000 FADS1 NR1H3
High blood pressure 3.27 4 1 3.0 0.73 0.2724 EIF2B4 KHK MADD NR1H3
Hayfever, allergic rhinitis or eczema 1.76 2 0 0.0 0.00 1.0000 AC074117.10 NRBP1
Medication: Levothyroxine sodium 1.44 1 0 0.0 0.00 1.0000 FADS1
Sitting height 2.34 5 3 9.1 -0.95 0.0012 AC074117.10 EIF2B4 FADS1 NOSTRIN NRBP1
High blood pressure (mother) 1.63 1 0 0.0 0.00 1.0000 NR1H3
Body mass index (BMI) 0.74 1 0 0.0 0.00 1.0000 MADD
Impedance of leg (left) 1.07 3 0 0.0 0.00 1.0000 AC074117.10 EIF2B4 NRBP1
Leg predicted mass (left) 2.42 6 4 12.1 -0.95 0.0032 AC074117.10 EIF2B4 MADD NOSTRIN NR1H3 NRBP1
Trunk fat mass 1.14 2 1 3.0 0.00 1.0000 KHK MADD
Waist circumference 1.04 2 0 0.0 0.00 1.0000 KHK MADD
Past tobacco smoking 0.94 1 0 0.0 0.00 1.0000 NOSTRIN
Nervous feelings 1.66 2 0 0.0 0.00 1.0000 MADD NR1H3
Had menopause 4.72 2 2 6.1 0.00 1.0000 AC074117.10 NRBP1
Forced vital capacity (FVC) 0.84 1 0 0.0 0.00 1.0000 NOSTRIN
Heel bone mineral density (BMD) T-score, automated (right) 1.74 2 1 3.0 0.00 1.0000 FADS1 NR1H3
Allergy 1.42 1 0 0.0 0.00 1.0000 FADS1
Diabetes (self-reported) 2.85 2 2 6.1 0.00 1.0000 AC074117.10 NRBP1
Medication: Ramipril 1.09 1 0 0.0 0.00 1.0000 NR1H3
Medication: Simvastatin 3.87 4 0 0.0 0.64 0.3610 AC074117.10 EIF2B4 FADS1 NRBP1
Fluid intelligence score 2.14 3 0 0.0 -0.53 0.4706 FADS1 KHK RP11-495O11.1
Neuroticism score 1.24 1 1 3.0 0.00 1.0000 NR1H3
Weight 1.67 4 4 12.1 -0.98 0.0240 AC074117.10 MADD NOSTRIN NRBP1
Impedance of arm (right) 1.54 3 3 9.1 0.00 1.0000 AC074117.10 EIF2B4 NRBP1
Arm fat percentage (right) 1.00 1 0 0.0 0.00 1.0000 MADD
Trunk fat-free mass 3.36 4 4 12.1 -0.96 0.0376 AC074117.10 EIF2B4 NOSTRIN NRBP1
Hip circumference 0.88 2 0 0.0 0.00 1.0000 MADD NOSTRIN
Alcohol intake versus 10 years previously 3.24 2 2 6.1 0.00 1.0000 AC074117.10 NRBP1
Number of live births 1.83 1 1 3.0 0.00 1.0000 FADS1
Forced expiratory volume in 1-second (FEV1) 0.74 2 0 0.0 0.00 1.0000 FADS1 NOSTRIN
Pulse rate 4.01 3 1 3.0 0.00 1.0000 AC074117.10 FADS1 NRBP1
Qualifications: A levels/AS levels or equivalent 0.96 1 0 0.0 0.00 1.0000 KHK
Asthma 1.54 1 1 3.0 0.00 1.0000 FADS1
Medication: Cholesterol lowering 4.85 3 2 6.1 0.00 1.0000 AC074117.10 EIF2B4 NRBP1
Forced expiratory volume in 1-second (FEV1), Best measure 0.65 1 0 0.0 0.00 1.0000 NOSTRIN
Impedance of arm (left) 1.70 3 3 9.1 0.00 1.0000 AC074117.10 EIF2B4 NRBP1
Arm fat mass (right) 1.03 1 0 0.0 0.00 1.0000 MADD
Trunk predicted mass 3.43 4 4 12.1 -0.96 0.0382 AC074117.10 EIF2B4 NOSTRIN NRBP1
Standing height 2.32 5 4 12.1 -0.93 0.0028 AC074117.10 EIF2B4 FADS1 NOSTRIN NRBP1
Tense / 'highly strung' 1.10 1 0 0.0 0.00 1.0000 NR1H3
Hair/balding pattern: Pattern 4 1.48 2 1 3.0 0.00 1.0000 FADS1 RP11-495O11.1
Peak expiratory flow (PEF) 0.72 1 0 0.0 0.00 1.0000 NOSTRIN
Blood clot in the leg (DVT) 1.81 2 0 0.0 0.00 1.0000 FADS1 MADD
Medication: Paracetamol 2.21 1 0 0.0 0.00 1.0000 NRBP1
Medication for cholesterol, blood pressure or diabetes 2.51 3 0 0.0 0.00 1.0000 AC074117.10 EIF2B4 NRBP1
Gout (self-reported) 10.19 3 3 9.1 0.95 0.0452 AC074117.10 EIF2B4 NRBP1
Hypothyroidism/myxoedema (self-reported) 1.08 1 0 0.0 0.00 1.0000 FADS1
Medication: Amlodipine 1.64 1 0 0.0 0.00 1.0000 NR1H3
High blood pressure (siblings) 2.73 2 0 0.0 0.00 1.0000 EIF2B4 NR1H3
Forced vital capacity (FVC), Best measure 0.75 1 0 0.0 0.00 1.0000 NOSTRIN
Body fat percentage 1.07 2 0 0.0 0.00 1.0000 KHK MADD
Leg fat percentage (right) 0.79 2 0 0.0 0.00 1.0000 FADS1 RP11-495O11.1
Arm fat-free mass (right) 3.07 5 4 12.1 -0.94 0.0157 AC074117.10 EIF2B4 MADD NOSTRIN NRBP1
Comparative body size at age 10 2.19 2 1 3.0 0.00 1.0000 AC074117.10 MADD
Seen a psychiatrist for nerves, anxiety, tension or depression 1.69 1 0 0.0 0.00 1.0000 FADS1
Wheeze or whistling in the chest in last year 1.21 1 0 0.0 0.00 1.0000 FADS1
Medication for pain relief, constipation, heartburn 2.51 2 0 0.0 0.00 1.0000 EIF2B4 NRBP1
Medication: Blood pressure 1.58 1 1 3.0 0.00 1.0000 NR1H3
Medication: Allopurinol 7.63 3 2 6.1 0.94 0.0563 AC074117.10 EIF2B4 NRBP1
Whole body fat mass 1.01 2 0 0.0 0.00 1.0000 KHK MADD
Leg fat mass (right) 0.95 1 0 0.0 0.00 1.0000 MADD
Arm predicted mass (right) 2.99 5 4 12.1 -0.95 0.0134 AC074117.10 EIF2B4 MADD NOSTRIN NRBP1
Pulse rate, automated reading 6.28 6 4 12.1 0.75 0.0500 AC074117.10 EIF2B4 FADS1 KHK NR1H3 NRBP1
Alcohol intake frequency. 7.94 4 4 12.1 0.98 0.0043 AC074117.10 EIF2B4 KHK NRBP1
Comparative height size at age 10 1.73 4 2 6.1 -0.98 0.0182 AC074117.10 MADD NOSTRIN NRBP1
Suffer from 'nerves' 1.64 2 0 0.0 0.00 1.0000 MADD NR1H3
Overall health rating 1.71 1 0 0.0 0.00 1.0000 NRBP1
Hypertension (Self-reported) 2.94 1 1 3.0 0.00 1.0000 NR1H3
Forced expiratory volume in 1-second (FEV1), predicted 2.51 2 1 3.0 0.00 1.0000 FADS1 NOSTRIN
Whole body fat-free mass 3.05 5 4 12.1 -0.95 0.0153 AC074117.10 EIF2B4 MADD NOSTRIN NRBP1
Leg fat-free mass (right) 2.47 6 4 12.1 -0.95 0.0035 AC074117.10 EIF2B4 MADD NOSTRIN NR1H3 NRBP1
Arm fat percentage (left) 1.13 1 1 3.0 0.00 1.0000 MADD
Mood swings 2.47 1 1 3.0 0.00 1.0000 NR1H3
Diabetes diagnosed by doctor 3.32 2 2 6.1 0.00 1.0000 AC074117.10 NRBP1
Medication for cholesterol 3.00 3 0 0.0 0.00 1.0000 AC074117.10 EIF2B4 NRBP1
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.35 1 0 0.0 0.00 1.0000 KHK
Asthma (self-reported) 1.69 1 1 3.0 0.00 1.0000 FADS1
Whole body water mass 3.10 5 4 12.1 -0.95 0.0148 AC074117.10 EIF2B4 MADD NOSTRIN NRBP1
Leg predicted mass (right) 2.48 6 4 12.1 -0.95 0.0034 AC074117.10 EIF2B4 MADD NOSTRIN NR1H3 NRBP1
Arm fat mass (left) 1.06 1 1 3.0 0.00 1.0000 MADD
Number of self-reported non-cancer illnesses 2.82 2 0 0.0 0.00 1.0000 AC074117.10 NRBP1
Average weekly champagne plus white wine intake 2.07 1 0 0.0 0.00 1.0000 FADS1
Miserableness 2.91 2 1 3.0 0.00 1.0000 MADD NR1H3
Guilty feelings 1.21 1 0 0.0 0.00 1.0000 NR1H3
Medication: Blood pressure 2.03 1 1 3.0 0.00 1.0000 NR1H3
Supplements: Fish oil (including cod liver oil) 1.71 1 0 0.0 0.00 1.0000 FADS1
High cholesterol (Self-reported) 9.49 5 3 9.1 0.82 0.0453 AC074117.10 EIF2B4 FADS1 KHK NRBP1
Medication: Bendroflumethiazide 1.99 2 1 3.0 0.00 1.0000 NOSTRIN NR1H3
Medication: Paracetamol 2.14 1 0 0.0 0.00 1.0000 NRBP1
Medication: Lisinopril 0.91 1 0 0.0 0.00 1.0000 NR1H3
Medication: Atorvastatin 4.93 2 2 6.1 0.00 1.0000 AC074117.10 NRBP1
Illnesses of father: High blood pressure 1.77 1 0 0.0 0.00 1.0000 NR1H3
Basal metabolic rate 2.65 5 3 9.1 -0.95 0.0123 AC074117.10 EIF2B4 MADD NOSTRIN NRBP1
Arm fat-free mass (left) 2.94 4 4 12.1 -0.96 0.0437 AC074117.10 EIF2B4 NOSTRIN NRBP1
Irritability 1.35 1 0 0.0 0.00 1.0000 FADS1
Risk taking 1.13 1 0 0.0 0.00 1.0000 KHK
Diastolic blood pressure, automated reading 1.32 2 1 3.0 0.00 1.0000 FADS1 NR1H3
Myopia 1.69 1 0 0.0 0.00 1.0000 RP11-495O11.1
Vascular/heart problems diagnosed by doctor 2.91 4 1 3.0 -0.91 0.0323 EIF2B4 KHK NR1H3 NRBP1
Cholesterol lowering medication 4.10 2 2 6.1 0.00 1.0000 AC074117.10 NRBP1
Deep venous thrombosis (DVT) (self-reported) 1.74 2 0 0.0 0.00 1.0000 FADS1 MADD
Impedance of whole body 1.44 3 3 9.1 0.00 1.0000 AC074117.10 EIF2B4 NRBP1
Leg fat mass (left) 0.98 1 0 0.0 0.00 1.0000 MADD
Arm predicted mass (left) 2.92 4 3 9.1 -0.95 0.0453 AC074117.10 EIF2B4 NOSTRIN NRBP1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 3 0.0865 1.20
GTEx Adipose Visceral Omentum 4 0.1974 1.29
GTEx Adrenal Gland 2 0.1379 1.28
GTEx Artery Aorta 1 0.0338 1.19
GTEx Artery Coronary 2 0.1696 1.26
GTEx Artery Tibial 4 0.1071 1.27
GTEx Brain Caudate basal ganglia 0 0.0000 1.25
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.18
GTEx Brain Cerebellum 3 0.1521 1.20
GTEx Brain Cortex 0 0.0000 1.17
GTEx Brain Frontal Cortex BA9 0 0.0000 1.27
GTEx Brain Hippocampus 0 0.0000 1.26
GTEx Brain Hypothalamus 1 0.1695 1.27
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.26
GTEx Brain Putamen basal ganglia 0 0.0000 1.20
GTEx Breast Mammary Tissue 0 0.0000 1.09
GTEx Breast Mammary Tissue (Male) 1 0.0845 1.20
GTEx Breast Mammary Tissue (Female) 1 0.0614 1.26
GTEx Cells EBV-transformed lymphocytes 2 0.1414 1.28
GTEx Cells Transformed fibroblasts 3 0.0718 1.16
GTEx Colon Sigmoid 1 0.0687 1.17
GTEx Colon Transverse 1 0.0488 1.24
GTEx Esophagus Gastroesophageal Junction 3 0.2088 1.26
GTEx Esophagus Mucosa 3 0.0909 1.22
GTEx Esophagus Muscularis 3 0.0932 1.22
GTEx Heart Atrial Appendage 0 0.0000 1.22
GTEx Heart Left Ventricle 0 0.0000 1.21
GTEx Liver 0 0.0000 1.14
GTEx Lung 4 0.1402 1.28
GTEx Muscle Skeletal 2 0.0696 1.25
GTEx Nerve Tibial 2 0.0465 1.17
GTEx Ovary 1 0.1109 1.31
GTEx Pancreas 1 0.0614 1.23
GTEx Pituitary 2 0.1795 1.24
GTEx Prostate 2 0.2407 1.27
GTEx Skin Not Sun Exposed Suprapubic 1 0.0409 1.23
GTEx Skin Sun Exposed Lower leg 3 0.0830 1.24
GTEx Small Intestine Terminal Ileum 0 0.0000 1.20
GTEx Spleen 0 0.0000 1.15
GTEx Stomach 1 0.0691 1.20
GTEx Testis 4 0.1273 1.21
GTEx Thyroid 3 0.0755 1.23
GTEx Uterus 0 0.0000 1.09
GTEx Vagina 2 0.3170 1.15
GTEx Whole Blood 2 0.1009 1.24
METSIM Adipose 4 0.0874 1.26
NTR Blood 2 0.0833 1.24
ROSMAP Brain Pre-frontal Cortex 8 0.1828 1.28
YFS Blood 1 0.0217 1.17
CommonMind Brain Pre-frontal Cortex 6 0.1118 1.22
TCGA Breast Tumor 0 0.0000 1.12
TCGA Breast Normal 3 0.0717 1.22
TCGA Ovarian Tumor 3 0.1030 1.17
TCGA Prostate Tumor 2 0.0580 1.24