Hub : Genes

ST3GAL5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.0580	0.0280	5.6e-03	-0.001	NA	0.014	NA	0.002	3.6e-01	NA	2.9e-02	NA	2.3e-01
2	YFS	Blood	0.1899	0.0309	0.0e+00	0.155	0.154	0.171	0.167	0.164	2.1e-48	4.7e-48	1.8e-53	2.8e-52	2.6e-51
3	TCGA	Breast Invasive Carcinoma	0.0365	0.0151	1.1e-08	0.058	0.047	0.059	NA	0.058	5.4e-12	5.0e-10	3.7e-12	NA	6.1e-12
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0303	0.0183	5.5e-03	0.011	0.013	0.009	NA	0.011	1.9e-02	1.2e-02	3.3e-02	NA	1.7e-02
5	TCGA	Prostate Adenocarcinoma	0.1310	0.0506	3.7e-09	0.109	0.108	0.092	NA	0.104	1.9e-11	2.4e-11	8.2e-10	NA	5.1e-11

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.6	2.5	5.4	-2.3	-0.7	1.8	1.2	1.4
Bipolar Disorder or Schizophrenia	1.5	3.6	7.7	-2.8	-0.9	1.8	1.6	1.9
Depressed Affect (Nagel 2018)	0.2	0.5	1.3	-0.3	-1.1	0.6	-0.0	0.8
Depression (Nagel 2018)	0.6	0.9	2.1	-1.0	0.3	-1.4	-0.9	-0.8
Intelligence (Savage-Jansen 2018)	0.6	1.7	5.5	-2.3	-1.2	1.0	-0.5	0.6
Neuroticism (Nagel 2018)	0.3	0.6	1.7	-0.7	0.1	0.9	-0.5	1.3
Schizophrenia (2018)	0.6	1.3	2.9	-1.7	-0.6	0.9	1.1	1.2
Schizophrenia vs Biploar Disorder	0.4	0.6	2.2	-0.2	-1.5	-0.1	0.8	0.1
Worry (Nagel 2018)	0.3	0.7	1.3	0.2	0.7	0.8	-1.0	1.1
Alzheimer’s Disease (in mother)	0.9	1.1	2.4	-1.6	-0.5	0.8	1.3	0.6
Alzheimer’s Disease (in father)	1.1	1.2	2.2	-1.2	-0.7	1.4	0.3	1.5
Alzheimer’s Disease (including proxy)	0.8	1.1	4.1	-2.0	-0.5	0.9	0.4	0.5
Crohns Disease (2017)	0.1	0.3	1.5	-1.2	0.1	0.1	-0.1	0.0
Irritable Bowel Disease (IBD)	1.0	2.4	4.5	0.8	1.0	-2.1	-1.5	-1.9
Ulcerative Colitis (UC)	2.4	4.5	5.9	2.1	1.6	-2.4	-2.2	-2.2
Major Depression (MDD)	0.6	0.7	1.5	-0.4	1.1	-0.6	-1.2	-0.7
Reaction Time	0.2	0.4	1.3	1.1	-0.3	0.3	0.7	-0.1
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.2	-1.2	-1.5	1.3	0.8	1.3
Breast Cancer	0.7	1.8	3.4	-1.2	0.3	1.9	0.8	1.8
Ovarian Cancer	3.8	5.0	9.9	-1.2	-3.2	1.2	2.8	2.1
Prostate Cancer	0.2	0.3	1.0	0.3	0.1	0.2	-1.0	0.6
Age at First Birth	1.3	1.9	4.1	0.4	0.6	-2.0	-1.6	-1.5
Bipolar Disorder (2011)	0.6	0.6	1.0	-0.0	-1.0	1.0	0.3	1.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.7	-0.4	0.3	-0.3	-0.9	-0.8
Coronary Artery Disease (CAD)	0.7	0.8	1.7	-1.3	0.2	1.1	0.6	0.8
Crohns Disease (2012)	0.2	0.4	1.3	-0.2	-1.1	0.1	0.5	0.3
Mean Putamen Volume	0.3	0.3	1.1	-1.0	0.6	0.4	-0.1	-0.1
Fasting Glucose	0.3	0.3	1.4	1.2	0.2	-0.3	0.0	0.2
HbA1C	0.2	0.2	0.8	-0.9	0.1	-0.1	-0.1	0.2
HDL Cholesterol	2.2	3.7	9.7	-3.1	-1.3	1.6	1.1	1.9
LDL Cholesterol	0.4	0.7	2.8	1.7	-0.1	-0.6	0.0	-0.7
Lupus	1.3	2.0	3.4	0.6	1.4	-1.4	-1.8	-1.5
Neuroticism (2016)	0.2	0.2	0.4	-0.1	0.6	0.4	-0.7	0.4
Primary Biliary Cirrhosis	0.3	0.4	0.9	1.0	0.2	-0.8	-0.2	-0.4
Rheumatoid Arthritis	1.0	1.4	3.8	-0.6	1.9	-0.7	-1.4	-0.6
Schizophrenia (2014)	1.2	2.6	4.6	-2.1	-1.4	1.3	1.4	1.6
Triglycerides	0.0	0.0	0.1	0.1	-0.1	0.0	0.2	-0.3
Type 2 Diabetes (T2D) (2012)	1.3	1.5	2.9	-0.2	-1.7	0.9	1.5	1.1
Ulcerative Colitis	4.1	5.9	10.3	1.8	1.3	-3.0	-2.4	-3.2
Blood Eosinophil Count	1.2	9.6	14.3	-0.1	3.3	-3.8	-3.3	-3.5
Blood Platelet Count	0.4	4.3	10.8	-3.3	2.3	-0.7	-1.9	-1.3
Blood Red Count	1.5	14.2	21.0	4.2	2.9	-4.6	-2.5	-4.3
Blood White Count	0.4	2.6	5.0	1.5	2.2	-1.8	-0.2	-1.6
Heel T-Score	0.2	2.0	6.4	-0.1	1.0	-1.5	-2.5	-0.5
BMI	0.2	1.0	3.8	-2.0	-0.0	0.4	0.7	0.5
Height	0.1	2.3	7.5	0.3	-0.0	-1.1	-2.7	-1.7
Waist Hip Ratio (WHR)	0.1	0.4	1.6	1.3	-0.2	-0.2	-0.1	-0.3
Systolic Blood Pressure	2.7	13.4	20.2	-2.4	-3.0	4.5	4.0	4.1
Smoking Status	0.9	2.3	8.4	2.9	-0.4	-1.1	-0.9	-0.9
Allergy or Eczema	1.8	4.8	8.6	-1.1	2.9	-1.9	-2.3	-2.3
Cardiovascular Disease	3.7	12.3	18.3	-2.4	-4.3	3.8	3.3	3.5
Hypothyroidism (self reported)	1.3	3.1	5.3	0.6	1.4	-1.8	-2.1	-2.3
Respiratory disease	0.5	1.1	1.6	-0.7	0.9	-1.1	-1.2	-1.3
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.8	1.3	-0.2	-1.0	-0.9	-1.0
Lung FEV1/FVC ratio	0.9	4.6	8.2	2.6	0.5	-2.9	-2.3	-1.5
Lung FVC	0.7	3.8	13.0	0.2	3.6	-0.4	-2.2	-0.9
Neuroticism	0.4	0.9	2.6	0.3	0.1	1.2	-0.5	1.6
Chronotype (morning person)	0.9	2.1	3.0	-1.5	-1.1	1.7	1.0	1.7
Hair Pigment	0.1	2.5	4.5	-0.3	-1.5	2.1	1.5	1.9
Tanning	0.2	2.5	4.8	1.4	0.4	-2.2	-1.4	-1.9
Hand grip strength (left)	0.1	0.3	0.5	-0.5	0.6	0.1	-0.7	-0.2
Number of treatments/medications taken	2.2	4.0	6.4	-0.2	-2.5	2.1	2.5	1.8
Average weekly spirits intake	2.5	3.1	5.2	1.7	1.1	-1.9	-2.3	-1.5
Sensitivity / hurt feelings	0.5	0.9	1.5	0.9	0.9	-1.1	-1.2	0.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	-1.0	-0.3	-0.1	0.5	0.5
Hearing difficulty/problems: Yes	0.7	1.1	3.8	-0.6	-1.0	0.4	1.9	0.1
Relative age of first facial hair	0.5	1.0	2.7	0.3	1.0	-0.6	-1.6	-0.9
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.0	-0.0	-0.0	-1.0	0.1	-1.4
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.1	-0.1	1.1	0.5	-0.1	-0.2
Ever had hysterectomy (womb removed)	2.5	2.8	4.7	1.8	0.9	-1.4	-1.8	-2.2
Systolic blood pressure, automated reading	0.3	0.9	1.8	0.1	-1.1	0.9	1.3	0.7
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	4.5	0.9	0.4	-1.4	-0.5	-2.1
Angina	2.1	2.8	3.7	0.1	-1.8	1.9	1.9	1.8
Medication for hormone replacement therapy	0.8	0.8	3.6	0.3	1.9	0.2	-0.7	-0.1
Vitamin and mineral supplements	0.3	0.4	0.8	-0.9	0.7	-0.3	-0.0	-0.7
Supplements: Zinc	1.2	1.3	4.8	-2.2	-0.7	1.0	0.4	-0.1
Medication: Co-codamol	0.1	0.1	0.2	0.2	0.1	-0.4	-0.3	-0.2
Medication: Metformin	0.1	0.2	0.4	-0.6	0.0	-0.0	-0.0	-0.6
Diabetes (father)	0.1	0.1	0.3	-0.4	-0.5	-0.1	0.3	-0.2
Diabetes (mother)	0.7	0.9	2.0	0.7	-1.3	-0.1	1.4	0.0
Severe depression (siblings)	0.4	0.4	0.6	-0.7	0.8	0.6	-0.4	0.7
Pack years adult smoking proportion	0.1	0.2	0.4	-0.1	0.4	0.3	0.6	0.4
Impedance of leg (right)	0.2	1.2	4.1	2.0	-0.1	0.7	0.8	0.8
Leg fat-free mass (left)	0.2	1.0	3.1	-1.8	-0.9	-0.4	-0.5	-0.7
Trunk fat percentage	0.0	0.2	0.3	-0.5	-0.4	0.2	0.6	0.1
Hand grip strength (right)	0.3	0.9	1.4	-1.2	-0.7	1.1	0.0	1.1
Townsend deprivation index at recruitment	0.1	0.2	0.4	0.2	0.5	0.2	-0.6	-0.3
Current tobacco smoking	2.9	4.7	17.7	4.2	0.6	-1.4	-1.4	-1.2
Average weekly fortified wine intake	0.4	0.5	1.1	-0.7	0.6	0.0	-1.1	-0.6
Maternal smoking around birth	0.1	0.1	0.3	0.3	-0.1	-0.6	-0.4	-0.2
Fed-up feelings	0.2	0.4	0.6	-0.2	-0.8	0.7	0.7	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.8	-0.9	-1.3	-0.3	0.8	0.0
Relative age voice broke	0.8	1.3	2.2	1.1	1.2	-0.8	-1.5	-1.0
Taking other prescription medications	0.5	0.8	1.7	-0.5	-1.3	0.9	0.7	0.6
Age when periods started (menarche)	0.4	0.9	2.7	1.6	-0.3	0.5	1.2	0.3
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	3.3	1.8	-1.1	0.5	0.6	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	3.5	1.9	-1.0	-1.6	-0.7	-0.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.1	0.2	-1.4	-0.3	1.0	0.0
Qualifications: CSEs or equivalent	0.3	0.4	1.4	-1.2	-0.2	-0.5	0.2	-0.6
Serious illness, injury or assault to yourself	0.3	0.4	1.6	0.2	-1.3	0.2	0.4	0.2
High blood pressure	2.5	7.1	9.3	-1.3	-2.8	2.9	3.0	2.9
Hayfever, allergic rhinitis or eczema	0.6	1.4	2.9	-0.3	1.7	-1.1	-1.3	-1.0
Multivitamins +/- minerals	0.1	0.1	0.3	0.5	0.2	0.1	-0.3	0.1
Stomach or abdominal pain in last month	0.5	0.6	1.5	1.2	-1.2	0.1	0.2	0.3
Supplements: Glucosamine	0.4	0.6	2.6	-1.6	-0.3	0.0	-0.2	-0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.8	0.3	0.4	-0.9	-0.5	-0.3
Medication: Atenolol	1.5	1.9	4.6	0.2	-2.1	1.1	1.8	0.5
Medication: Levothyroxine sodium	0.1	0.1	0.5	0.2	-0.2	-0.3	-0.2	-0.7
Sitting height	0.2	1.4	3.0	0.5	-1.0	-1.2	-1.7	-1.2
Chronic bronchitis/emphysema (father)	0.1	0.2	0.3	-0.4	-0.3	-0.0	0.5	-0.5
High blood pressure (mother)	12.0	16.9	27.8	-2.2	-4.0	4.6	3.9	5.3
Body mass index (BMI)	0.2	0.9	4.1	-2.0	-0.3	0.4	0.5	0.3
Impedance of leg (left)	0.3	1.5	5.3	2.3	-0.4	0.5	1.1	0.8
Leg predicted mass (left)	0.2	1.0	3.2	-1.8	-0.9	-0.4	-0.5	-0.7
Trunk fat mass	0.1	0.4	1.0	-1.0	-0.7	0.1	0.5	-0.1
Waist circumference	0.1	0.5	1.9	-1.4	-0.3	0.3	0.8	0.0
Number of incorrect matches in round	0.1	0.2	0.6	0.8	-0.3	0.2	0.3	0.3
Past tobacco smoking	0.1	0.2	0.5	-0.1	-0.3	0.7	0.2	0.5
Alcohol usually taken with meals	1.6	2.6	3.7	-1.9	-0.5	1.9	1.4	1.9
Nervous feelings	0.7	1.3	3.4	-0.3	-0.4	1.6	0.4	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.8	0.5	-0.9	0.4	0.5	0.7
Hearing difficulty/problems with background noise	0.6	0.9	1.6	0.4	1.2	-1.2	-0.2	-1.2
Hair/balding pattern: Pattern 2	1.5	1.9	4.1	2.0	-0.0	-1.8	-0.7	-1.3
Had menopause	1.4	1.7	2.5	1.6	1.5	-0.8	-1.4	-1.1
Had other major operations	0.5	0.6	2.4	-0.4	1.6	-0.1	-0.6	-0.4
Forced vital capacity (FVC)	0.7	2.7	6.1	-0.3	1.9	-1.4	-2.5	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	1.8	1.3	-0.5	-1.3	-0.7	-0.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.8	-0.4	-0.8	0.6	0.5	1.3
Qualifications: None of the above	0.3	0.6	1.5	0.1	0.8	-0.9	0.4	-1.2
Financial difficulties in last 2 years	1.0	1.3	5.1	2.3	-0.9	-0.6	0.4	-0.1
Mouth/teeth dental problems	0.3	0.5	2.0	-1.4	-0.0	0.4	-0.1	0.6
Heart attack	1.0	1.2	4.0	0.4	-2.0	1.1	0.8	0.4
Allergy	1.3	3.1	5.4	-0.4	-1.5	2.1	2.3	1.8
Pain all over the body in last month	0.1	0.1	0.5	-0.7	0.1	0.1	0.2	-0.0
Diabetes (self-reported)	0.4	0.5	1.8	0.1	0.1	-0.6	-0.7	-1.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	-0.7	0.1	0.6	-0.2	0.9
Medication: Ramipril	1.3	1.7	3.6	-0.0	-1.9	1.3	0.9	1.6
Medication: Simvastatin	1.6	2.3	3.8	-0.9	-1.6	1.8	1.9	1.1
Fluid intelligence score	1.3	2.7	4.4	-1.5	-2.1	1.5	1.1	1.8
Illnesses of siblings	3.3	4.6	13.0	-0.0	3.6	-0.7	-2.7	-1.6
Neuroticism score	0.3	0.7	2.1	0.7	-0.3	0.9	0.1	1.4
Weight	0.1	0.6	2.5	-1.6	-0.7	-0.0	-0.1	-0.2
Impedance of arm (right)	0.2	1.1	2.8	1.7	0.6	-1.1	-0.5	-0.9
Arm fat percentage (right)	0.1	0.4	1.6	-1.3	-0.1	-0.1	0.5	-0.2
Trunk fat-free mass	0.1	0.8	2.6	-1.6	-1.0	-0.0	-0.3	-0.5
Hip circumference	0.2	0.8	2.6	-1.6	-0.8	0.2	0.7	0.2
Time employed in main current job	0.9	1.0	2.9	0.3	1.7	-0.9	-0.0	-1.1
Alcohol intake versus 10 years previously	0.5	0.8	2.8	0.1	-1.0	0.3	1.7	0.0
Father’s age at death	0.2	0.3	1.0	-1.0	-0.1	-0.2	-0.3	-0.3
Worrier / anxious feelings	0.5	1.0	2.2	1.5	-0.6	0.4	-0.5	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.6	0.5	-1.3	-0.8	0.3	-0.5
Falls in the last year	0.3	0.3	0.7	0.0	-0.4	0.8	0.7	0.7
Hair/balding pattern: Pattern 3	0.3	0.5	1.1	-1.0	1.1	0.5	-0.0	-0.1
Number of live births	0.6	0.9	2.0	0.9	-0.2	1.4	0.4	1.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	6.1	0.7	1.3	-1.5	-2.5	-1.2
Pulse rate	0.9	1.5	2.6	-0.6	1.3	-1.1	-1.6	-1.3
Happiness	2.4	2.9	4.2	-1.9	-1.7	1.4	1.4	2.0
Noisy workplace	3.2	3.9	7.7	1.5	1.4	-2.5	-1.3	-2.8
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.5	-1.6	0.8	0.6	-0.2	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	3.4	1.8	-0.6	-1.0	-0.5	-0.7
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	0.7	-0.3	0.3	0.4	0.4
Asthma	0.4	0.7	1.5	0.5	0.2	-1.1	-1.2	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	2.5	0.4	0.9	-1.2	-0.7	-1.6
Medication: Cholesterol lowering	2.6	4.1	8.8	-1.3	-3.0	1.8	1.8	1.9
Depression (self-reported)	2.4	2.8	6.4	-1.0	-0.7	2.3	1.0	2.5
Medication: Lansoprazole	0.3	0.3	0.8	-0.4	-0.7	0.9	0.3	0.4
Prospective memory result	0.6	0.8	1.9	-0.9	1.4	1.1	0.3	0.3
Lung cancer (father)	4.5	5.2	9.7	0.5	3.1	-2.0	-2.3	-2.5
Illnesses of mother	3.8	4.7	9.1	1.1	2.0	-2.1	-2.3	-3.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.9	0.2	0.8	-1.0	-1.4	-0.9
Pulse wave Arterial Stiffness index	0.7	0.8	1.9	-1.4	0.2	1.3	-0.2	0.8
Impedance of arm (left)	0.4	1.9	4.3	2.1	1.0	-1.3	-1.3	-0.9
Arm fat mass (right)	0.2	0.6	2.5	-1.6	-0.2	-0.4	-0.1	-0.6
Trunk predicted mass	0.1	0.8	2.5	-1.6	-1.0	-0.0	-0.3	-0.5
Standing height	0.1	1.2	1.8	0.8	-1.0	-1.1	-1.3	-1.2
Length of working week for main job	0.1	0.1	0.5	-0.1	0.7	0.1	-0.0	0.1
Exposure to tobacco smoke at home	1.5	1.7	3.6	0.8	-1.4	0.9	1.9	1.2
Breastfed as a baby	0.7	0.9	2.1	-0.4	1.3	0.3	-1.4	-0.5
Tense / ‘highly strung’	0.5	0.8	1.9	-0.1	-0.6	1.1	0.4	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	2.8	-1.0	-1.5	1.1	1.7	1.0
Hair/balding pattern: Pattern 4	0.3	0.8	1.8	1.3	-1.3	-0.8	0.2	-0.1
Birth weight of first child	1.2	2.2	6.4	-2.5	-0.4	1.7	0.2	1.3
Peak expiratory flow (PEF)	0.8	1.9	5.2	-0.0	0.6	-1.4	-2.3	-1.4
Pulse wave reflection index	0.7	0.8	1.8	-1.1	-0.3	1.4	0.9	0.6
Ever highly irritable/argumentative for 2 days	3.5	4.2	7.9	-0.6	-1.9	1.9	2.3	2.8
Loud music exposure frequency	0.3	0.4	1.0	0.1	0.1	-1.0	0.1	-0.9
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.0	-1.0	0.3	0.5	0.2	0.4
Mouth/teeth dental problems: Bleeding gums	1.0	1.2	2.4	-1.0	1.3	-0.9	-1.5	-0.6
Blood clot in the leg (DVT)	0.4	0.5	0.7	0.8	0.3	-0.8	-0.8	-0.6
Medication: Paracetamol	0.4	0.6	1.2	0.8	-0.1	1.1	1.1	0.5
Headache pain in last month	1.0	1.7	6.2	2.5	-0.1	-0.8	-0.5	-1.3
Medication for cholesterol, blood pressure or diabetes	3.9	6.4	10.0	1.9	3.2	-2.8	-2.1	-2.5
Glaucoma (self-reported)	1.0	1.1	2.9	-1.1	-0.2	1.7	0.3	1.2
Gout (self-reported)	2.1	2.8	5.3	-1.0	-0.8	1.8	2.0	2.3
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	5.2	0.9	1.1	-1.6	-1.6	-2.3
Medication: Amlodipine	0.5	0.7	1.7	-1.3	-0.9	0.9	0.6	0.2
Medication: Ventolin 100micrograms inhaler	2.6	3.3	5.1	0.9	1.3	-2.2	-2.3	-2.0
Birth weight	0.4	0.9	1.7	-1.0	0.4	-1.3	-0.8	-0.9
Chronic bronchitis/emphysema (mother)	2.2	2.6	3.6	0.7	1.8	-1.5	-1.9	-1.8
High blood pressure (siblings)	5.5	8.0	14.0	-0.8	-3.7	1.9	3.5	3.1
Forced vital capacity (FVC), Best measure	0.8	3.1	5.2	-0.4	2.0	-1.6	-2.3	-1.9
Body fat percentage	0.1	0.3	0.6	-0.8	-0.4	0.3	0.8	0.3
Leg fat percentage (right)	0.3	0.9	2.8	-1.7	0.0	0.8	1.0	0.6
Arm fat-free mass (right)	0.1	0.5	1.6	-1.0	-1.3	0.2	0.1	-0.1
Exposure to tobacco smoke outside home	1.1	1.4	3.4	1.9	-0.2	-1.5	0.3	-1.2
Comparative body size at age 10	1.1	3.0	7.8	-2.8	-1.0	0.9	1.1	2.0
Number of full brothers	0.2	0.3	1.0	0.2	-0.1	-1.0	0.1	-0.6
Worry too long after embarrassment	0.4	0.6	1.6	-0.5	0.7	0.7	-0.5	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.2	-0.6	-1.0	1.5	1.0	1.4
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	-0.6	-0.3	-0.2	0.6	0.4
Number of children fathered	1.3	1.5	2.0	1.2	1.4	-1.2	-1.2	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.9	-1.0	-0.3	-0.0	0.5	0.4
Age at first live birth	1.5	2.7	6.3	-2.5	1.8	-1.1	-1.6	-0.4
Pulse wave peak to peak time	0.7	0.8	1.7	1.3	-0.7	-1.1	0.4	-0.6
Health satisfaction	0.5	0.7	2.7	-0.6	-1.6	0.4	-0.0	0.4
Shortness of breath walking on level ground	1.3	1.6	2.7	-1.6	-0.5	1.5	0.8	1.4
Qualifications: College or University degree	0.4	1.3	2.7	-1.6	-0.7	1.1	-0.1	1.4
Eye problems/disorders: None of the above	0.1	0.1	0.4	-0.2	-0.1	0.4	0.3	0.6
Mouth/teeth dental problems: Loose teeth	2.4	2.9	5.1	2.2	0.9	-1.9	-1.2	-1.8
Emphysema/chronic bronchitis	0.7	0.8	1.7	-0.3	0.4	-1.2	-0.6	-1.3
Medication for pain relief, constipation, heartburn	2.3	3.9	6.9	0.3	2.1	-2.6	-2.2	-1.8
Neck or shoulder pain in last month	0.3	0.4	1.0	1.0	-0.4	0.2	1.0	-0.2
Medication: Blood pressure	5.3	9.4	12.7	-2.3	-3.1	3.6	3.0	3.2
Angina (self-reported)	1.9	2.5	3.5	0.1	-1.7	1.9	1.8	1.7
Migraine (self-reported)	0.0	0.0	0.1	0.2	0.0	-0.3	-0.0	-0.0
Medication: Ibuprofen	0.8	1.0	1.8	-0.1	1.4	-1.0	-0.8	-1.2
Medication: Allopurinol	1.4	1.9	3.7	-0.5	-0.3	1.5	1.8	1.9
Medication: Omeprazole	0.6	0.7	2.0	1.0	-1.4	-0.3	-0.3	-0.2
Medication: Seretide 50 evohaler	1.7	1.9	4.4	0.8	0.2	-2.1	-1.2	-1.8
Mean time to correctly identify matches	0.2	0.3	0.7	0.8	0.1	0.5	0.7	-0.2
Heart disease (mother)	0.2	0.3	0.9	1.0	0.0	-0.2	0.6	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.8	-0.5	-1.0	0.4	1.3	0.4
Whole body fat mass	0.1	0.6	2.1	-1.4	-0.7	0.3	0.6	0.1
Leg fat mass (right)	0.2	1.0	3.7	-1.9	-0.4	0.6	0.8	0.2
Arm predicted mass (right)	0.2	0.8	1.9	-1.4	-1.4	0.4	0.3	0.0
Pulse rate, automated reading	0.4	1.3	3.9	-2.0	0.9	-0.6	-0.1	-1.1
Alcohol intake frequency.	0.6	1.4	6.0	0.6	-2.4	-0.3	0.8	-0.2
Comparative height size at age 10	0.2	1.2	3.4	0.7	-1.8	0.4	0.9	1.0
Number of full sisters	0.4	0.5	1.0	0.1	-0.4	-0.7	-1.0	-1.0
Suffer from ‘nerves’	0.4	0.7	2.7	0.4	1.6	0.2	-0.5	0.5
Overall health rating	0.8	1.7	4.9	2.2	-1.0	-1.1	0.7	-1.0
Chest pain or discomfort	0.1	0.1	0.3	-0.4	-0.4	0.3	0.5	0.2
Had major operations	0.7	0.8	1.4	1.0	-1.2	-0.7	-0.2	-1.0
Age at last live birth	0.6	0.9	3.4	-1.8	0.6	0.3	-0.3	0.7
Family relationship satisfaction	2.2	2.7	4.0	-1.4	-1.4	1.7	2.0	1.7
Leg pain on walking	0.0	0.0	0.1	0.3	-0.1	-0.2	-0.3	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.6	0.4	0.8	-0.5	-1.3	-1.0
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.5	-0.8	0.5	0.8	0.1	1.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.1	-1.4	0.3	0.9	0.1	1.0
Medication: Aspirin	4.0	5.3	8.0	-0.7	-2.3	2.8	2.8	2.2
Supplements: Vitamin C	0.2	0.2	1.0	0.0	-1.0	0.1	-0.4	-0.2
Knee pain experienced in last month	0.8	1.2	2.2	-0.5	-0.8	1.2	1.5	1.3
Hypertension (Self-reported)	1.9	5.4	7.7	-1.1	-2.8	2.4	2.6	2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.8	-0.3	-0.2	0.9	-0.1	0.3
Illnesses of father: Heart disease	1.2	1.7	2.0	1.2	-1.3	1.3	1.2	1.4
Illnesses of siblings: Diabetes	0.3	0.3	1.0	0.5	-1.0	-0.5	0.2	0.0
Smoking status: Previous	0.2	0.3	1.2	-1.1	-0.0	-0.4	0.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.8	-0.6	-0.7	-1.7	-0.8	-1.2
Whole body fat-free mass	0.2	0.9	2.8	-1.7	-1.1	-0.1	-0.2	-0.5
Leg fat-free mass (right)	0.2	1.0	2.9	-1.7	-1.1	-0.5	-0.4	-0.7
Arm fat percentage (left)	0.1	0.3	1.2	-1.1	0.1	-0.3	0.1	-0.2
Average weekly red wine intake	0.6	0.9	3.5	0.4	0.3	-0.8	-1.9	-0.6
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.2	0.6	0.1	-1.0	-1.0	-1.1
Mood swings	0.1	0.3	0.6	0.8	-0.7	-0.2	0.1	0.3
Loneliness, isolation	0.6	0.8	1.8	-0.9	-0.1	1.1	0.5	1.4
Long-standing illness, disability or infirmity	0.5	0.8	1.7	-0.4	-1.3	-0.5	0.1	-1.3
Ever had bowel cancer screening	0.6	0.8	1.7	-1.1	-0.3	1.3	0.1	0.9
Diabetes diagnosed by doctor	0.1	0.2	0.5	0.2	-0.4	-0.3	-0.2	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.1	0.4	-0.4	0.0	-0.4
Friendships satisfaction	1.7	2.1	2.6	-1.6	-1.4	1.4	1.2	1.6
Qualifications: nursing, teaching	2.3	3.6	5.8	-2.1	-1.0	2.4	1.4	2.2
Commuting to job workplace: Walk	0.4	0.4	1.7	1.3	-0.7	-0.0	0.2	-0.0
Eye problems/disorders: Cataract	1.8	2.1	2.8	-1.4	-1.1	1.6	1.7	1.5
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.0	0.1	-1.0	0.7	1.4	0.7
Medication for cholesterol	0.6	1.0	2.0	1.4	-0.0	-1.2	-1.0	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.9	1.0	-0.2	-0.1	0.3	-0.2
Back pain experienced in last month	1.2	1.7	4.8	2.2	-1.1	-1.1	-0.1	-1.1
Mineral and other dietary supplements	0.7	1.0	3.3	1.8	-0.6	-0.8	-0.3	-0.7
Breast cancer (self-reported)	0.4	0.4	1.9	-1.4	0.4	-0.1	-0.1	-0.4
Asthma (self-reported)	0.2	0.5	1.2	0.1	0.0	-0.9	-1.1	-0.6
Osteoporosis (self-reported)	0.2	0.2	0.6	-0.5	0.1	0.8	0.5	0.4
Osteoarthritis (self-reported)	0.2	0.2	0.7	-0.8	-0.6	0.2	0.1	-0.1
Medication: Aspirin	5.4	7.0	10.4	-1.0	-2.6	3.1	3.2	2.7
Medication: Gliclazide	0.1	0.1	0.2	-0.4	0.1	-0.1	-0.2	-0.4
Illnesses of father: None of the above (group 1)	3.2	3.9	5.9	1.2	2.2	-2.0	-2.4	-1.8
Smoking status: Current	2.5	4.0	15.8	4.0	0.4	-1.2	-1.3	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	7.1	-0.7	2.7	-0.9	-2.1	-1.1
Whole body water mass	0.1	0.8	2.6	-1.6	-1.1	-0.2	-0.2	-0.5
Leg predicted mass (right)	0.2	1.0	3.2	-1.8	-1.0	-0.5	-0.4	-0.7
Arm fat mass (left)	0.1	0.5	2.2	-1.5	-0.1	-0.3	-0.1	-0.4
Number of self-reported non-cancer illnesses	0.9	1.5	3.3	-0.6	-1.8	1.3	1.1	0.9
Average weekly champagne plus white wine intake	0.3	0.4	1.3	-0.2	1.1	0.5	-0.3	0.3
Miserableness	0.2	0.3	0.7	0.3	-0.6	-0.4	-0.8	-0.2
Guilty feelings	0.3	0.4	0.7	-0.8	0.7	0.7	0.0	0.6
Wears glasses or contact lenses	0.7	0.8	2.2	0.6	1.5	0.7	-1.0	0.1
Ever taken oral contraceptive pill	0.6	0.7	1.5	0.7	1.0	-0.4	-1.2	0.6
Hearing aid user	1.6	1.8	4.3	-2.1	0.0	1.4	0.8	1.5
Mother’s age at death	0.2	0.2	0.5	0.4	-0.3	0.7	0.3	0.6
Financial situation satisfaction	0.1	0.1	0.2	0.5	-0.1	0.2	0.4	0.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.5	-1.2	0.7	-0.9	-0.4	-0.8
Commuting to job workplace: Public transport	0.2	0.2	0.8	-0.9	0.1	0.0	0.4	-0.5
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	-0.3	-0.3	0.5	-0.7	0.4
Medication: Blood pressure	0.3	0.6	1.7	-0.0	-1.3	0.6	0.9	0.4
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.9	0.2	0.4	-0.3	-1.4	-0.5
Supplements: Fish oil (including cod liver oil)	1.5	2.0	4.1	-1.6	2.0	-0.3	-1.7	-0.4
High cholesterol (Self-reported)	1.3	2.3	4.6	-1.3	-2.1	1.4	1.3	1.2
Medication: Bendroflumethiazide	0.6	1.0	1.5	-1.0	-0.4	1.2	0.9	1.1
Medication: Paracetamol	0.5	0.8	1.9	0.4	-0.5	1.1	1.4	0.6
Medication: Lisinopril	4.6	5.9	11.2	-3.4	-0.8	2.7	2.4	2.1
Medication: Atorvastatin	2.0	2.4	5.9	-2.1	-2.4	0.4	1.1	0.6
Illnesses of father: High blood pressure	3.3	4.1	6.2	-1.6	-2.5	1.6	2.0	2.2
Alcohol drinker status: Never	0.5	0.6	1.0	-0.9	0.6	-0.7	-0.6	-1.0
Ever smoked	0.8	1.5	5.2	2.3	0.6	-1.1	-0.4	-0.6
Basal metabolic rate	0.2	0.8	2.8	-1.7	-0.9	-0.3	-0.4	-0.6
Leg fat percentage (left)	0.2	0.8	2.4	-1.5	-0.2	0.6	1.0	0.5
Arm fat-free mass (left)	0.2	0.8	2.8	-1.7	-1.0	0.1	0.1	-0.3
Number of operations (self-reported)	0.2	0.2	0.6	-0.8	-0.2	0.5	0.4	0.2
Average weekly beer plus cider intake	2.7	3.8	6.9	1.2	0.9	-2.6	-2.2	-2.2
Irritability	1.0	1.7	5.4	-0.4	-2.3	0.7	1.2	1.0
Risk taking	0.4	0.5	0.9	0.7	-0.2	0.9	1.0	0.6
Ever had prostate specific antigen (PSA) test	1.6	1.9	5.8	-2.4	1.5	1.0	-0.1	0.6
Fractured/broken bones in last 5 years	0.4	0.5	1.2	1.1	-0.7	-0.7	0.3	-0.4
Age started oral contraceptive pill	1.3	1.6	2.6	-0.0	1.3	-1.3	-1.6	-1.4
Diastolic blood pressure, automated reading	1.3	4.0	8.3	1.1	-2.9	1.5	2.1	1.8
Ever depressed for a whole week	2.3	2.9	7.0	0.0	-2.6	0.9	1.7	1.9
Unable to work because of sickness or disability	0.2	0.2	0.6	-0.3	-0.8	-0.5	0.2	-0.5
Commuting to job workplace: Cycle	0.5	0.6	1.4	-1.0	1.2	-0.0	-0.5	-0.1
Myopia	0.2	0.3	0.6	-0.8	-0.2	0.4	-0.8	0.4
Vascular/heart problems diagnosed by doctor	3.1	8.5	11.5	1.1	3.4	-3.2	-3.2	-3.1
Cholesterol lowering medication	0.3	0.5	1.6	-1.3	-0.4	0.6	0.5	0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.7	0.6	-0.8	0.1	-0.3	0.1
Pain experienced in last month	0.4	0.7	2.0	-1.4	0.9	0.2	-0.3	0.6
Supplements: Calcium	2.1	2.4	4.7	-1.1	-0.7	2.2	1.4	1.9
Basal cell carcinoma (self-reported)	0.3	0.3	1.0	-0.7	0.3	0.3	-1.0	0.1
Heart attack/myocardial infarction (self-reported)	0.9	1.2	3.9	0.4	-2.0	1.1	0.8	0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.8	0.3	0.4	-0.7	-0.9	-0.5
Heart disease (siblings)	0.7	0.8	2.0	-0.8	-1.4	0.3	0.8	0.9
Alcohol drinker status: Previous	0.4	0.4	0.7	-0.7	-0.5	-0.7	-0.4	-0.9
Pack years of smoking	0.2	0.4	0.6	-0.5	0.2	0.6	0.8	0.8
Impedance of whole body	0.3	1.7	7.7	2.8	0.4	-0.7	-0.4	-0.2
Leg fat mass (left)	0.2	0.8	3.3	-1.8	-0.4	0.4	0.7	0.1
Arm predicted mass (left)	0.2	0.8	2.4	-1.6	-1.2	0.3	0.3	-0.1