Hub : Traits :

High blood pressure (mother)

21 significantly associated models · 9 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 26428864 27820430 1 1 1.4e-07 3.5e-06 9.6e-01 100 PIGV
2 3 26720690 28211713 1 1 3.3e-07 1.6e-07 1.7e-01 93 SLC4A7
3 6 127066190 128536730 1 1 3.9e-08 7.7e-15 3.7e-08 50 C6orf174
4 10 103987875 105531761 1 1 2.4e-07 1.1e-07 1.0e+00 100 CNNM2
5 12 47671905 49061511 1 1 2.7e-08 1.1e-05 4.5e-04 36 TMEM106C
6 12 53757831 55214279 1 1 3.4e-08 6.9e-09 3.2e-02 86 FLJ12825
7 15 90712555 92135418 2 1 9.4e-20 1.4e-19 1.7e-01 98 FES
8 17 46303558 47688526 1 1 9.2e-08 7.7e-08 7.4e-02 89 UBE2Z

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.16 1 0 0.0 0.00 1.00000 FES
Irritable Bowel Disease (IBD) 0.88 1 0 0.0 0.00 1.00000 FES
Major Depression (MDD) 3.77 2 0 0.0 0.00 1.00000 CNNM2 FES
Breast Cancer 8.93 2 1 3.0 0.00 1.00000 FES SLC4A7
Ovarian Cancer 1.92 1 0 0.0 0.00 1.00000 FES
Body Mass Index (BMI) (2010) 3.00 1 0 0.0 0.00 1.00000 CNNM2
Coronary Artery Disease (CAD) 5.29 2 0 0.0 0.00 1.00000 CNNM2 UBE2Z
Crohns Disease (2012) 1.27 1 0 0.0 0.00 1.00000 FES
HDL Cholesterol 3.17 1 0 0.0 0.00 1.00000 PIGV
LDL Cholesterol 2.51 1 0 0.0 0.00 1.00000 PIGV
Rheumatoid Arthritis 1.32 1 0 0.0 0.00 1.00000 TMEM106C
Schizophrenia 6.59 3 2 6.1 0.00 1.00000 CNNM2 FES PIGV
Triglycerides 1.73 1 0 0.0 0.00 1.00000 C6orf174
Type 2 Diabetes (T2D) 1.81 1 0 0.0 0.00 1.00000 UBE2Z
Blood Eosinophil Count 1.24 2 2 6.1 0.00 1.00000 PIGV UBE2Z
Blood Platelet Count 3.00 6 4 12.1 -0.03 0.95542 C6orf174 FLJ12825 PIGV SLC4A7 TMEM106C UBE2Z
Blood Red Count 2.57 4 3 9.1 0.35 0.65352 C6orf174 CNNM2 FES TMEM106C
Blood White Count 1.31 2 1 3.0 0.00 1.00000 CNNM2 FES
Heel T-Score 5.84 4 1 3.0 0.56 0.44302 C6orf174 CNNM2 SLC4A7 TMEM106C
BMI 2.72 2 2 6.1 0.00 1.00000 CNNM2 UBE2Z
Height 2.53 6 3 9.1 0.82 0.04484 C6orf174 CNNM2 FES PIGV SLC4A7 UBE2Z
Waist Hip Ratio (WHR) 4.01 2 2 6.1 0.00 1.00000 C6orf174 FLJ12825
Systolic Blood Pressure 21.52 7 5 15.2 -0.96 0.00066 C6orf174 CNNM2 FES PIGV SLC4A7 TMEM106C UBE2Z
Smoking Status 1.82 1 0 0.0 0.00 1.00000 FES
Allergy or Eczema 1.05 1 0 0.0 0.00 1.00000 FES
Cardiovascular Disease 16.14 8 6 18.2 -0.96 0.00011 C6orf174 CNNM2 FES FLJ12825 PIGV SLC4A7 TMEM106C UBE2Z
Hypothyroidism (self reported) 0.86 1 0 0.0 0.00 1.00000 UBE2Z
Respiratory disease 1.48 1 0 0.0 0.00 1.00000 FES
Type 2 Diabetes (T2D) 3.08 1 0 0.0 0.00 1.00000 UBE2Z
Lung FEV1/FVC ratio 1.77 2 1 3.0 0.00 1.00000 C6orf174 FLJ12825
Lung FVC 1.07 2 0 0.0 0.00 1.00000 CNNM2 FLJ12825
Neuroticism 2.50 2 1 3.0 0.00 1.00000 CNNM2 UBE2Z
Hair Pigment 0.30 2 1 3.0 0.00 1.00000 FES PIGV
Number of treatments/medications taken 4.29 2 0 0.0 0.00 1.00000 FES SLC4A7
Sensitivity / hurt feelings 3.31 2 0 0.0 0.00 1.00000 FES UBE2Z
Hearing difficulty/problems: Yes 1.30 1 0 0.0 0.00 1.00000 SLC4A7
Systolic blood pressure, automated reading 13.75 6 4 12.1 0.92 0.01002 C6orf174 CNNM2 FES PIGV SLC4A7 UBE2Z
Angina 6.18 1 1 3.0 0.00 1.00000 FES
Diabetes (father) 2.41 1 0 0.0 0.00 1.00000 UBE2Z
Impedance of leg (right) 4.38 6 2 6.1 0.24 0.65051 CNNM2 FES FLJ12825 SLC4A7 TMEM106C UBE2Z
Leg fat-free mass (left) 1.95 2 1 3.0 0.00 1.00000 CNNM2 FES
Trunk fat percentage 1.94 5 0 0.0 0.71 0.17763 C6orf174 CNNM2 FLJ12825 SLC4A7 UBE2Z
Current tobacco smoking 1.82 1 0 0.0 0.00 1.00000 FES
Fed-up feelings 1.32 1 0 0.0 0.00 1.00000 UBE2Z
Heel bone mineral density (BMD) T-score, automated (left) 3.83 1 1 3.0 0.00 1.00000 C6orf174
High blood pressure 16.85 7 6 18.2 0.95 0.00127 C6orf174 CNNM2 FES FLJ12825 PIGV SLC4A7 UBE2Z
Diverticular disease/diverticulitis (self-reported) 1.56 1 0 0.0 0.00 1.00000 SLC4A7
Medication: Atenolol 8.29 3 1 3.0 0.00 1.00000 FES PIGV SLC4A7
Sitting height 2.30 4 1 3.0 -0.97 0.02559 FES PIGV SLC4A7 UBE2Z
Body mass index (BMI) 2.35 2 2 6.1 0.00 1.00000 CNNM2 UBE2Z
Impedance of leg (left) 3.93 6 1 3.0 0.20 0.70649 CNNM2 FES FLJ12825 SLC4A7 TMEM106C UBE2Z
Leg predicted mass (left) 1.88 2 1 3.0 0.00 1.00000 CNNM2 FES
Trunk fat mass 1.40 1 0 0.0 0.00 1.00000 CNNM2
Waist circumference 1.53 2 0 0.0 0.00 1.00000 C6orf174 CNNM2
Number of incorrect matches in round 2.21 1 0 0.0 0.00 1.00000 FES
Alcohol usually taken with meals 2.14 1 0 0.0 0.00 1.00000 FES
Nervous feelings 3.15 1 1 3.0 0.00 1.00000 CNNM2
Frequency of tenseness / restlessness in last 2 weeks 1.93 1 0 0.0 0.00 1.00000 CNNM2
Hearing difficulty/problems with background noise 2.26 2 0 0.0 0.00 1.00000 SLC4A7 UBE2Z
Forced vital capacity (FVC) 0.95 1 0 0.0 0.00 1.00000 UBE2Z
Heel bone mineral density (BMD) T-score, automated (right) 3.15 1 1 3.0 0.00 1.00000 C6orf174
Qualifications: None of the above 0.95 1 0 0.0 0.00 1.00000 UBE2Z
Heart attack 4.19 2 0 0.0 0.00 1.00000 CNNM2 FES
Allergy 0.84 1 0 0.0 0.00 1.00000 FES
Diabetes (self-reported) 2.23 1 0 0.0 0.00 1.00000 UBE2Z
Medication: Ramipril 4.14 2 0 0.0 0.00 1.00000 CNNM2 FES
Medication: Simvastatin 6.22 3 0 0.0 0.00 1.00000 FES PIGV UBE2Z
Illnesses of siblings 5.38 2 1 3.0 0.00 1.00000 FES UBE2Z
Neuroticism score 2.13 2 0 0.0 0.00 1.00000 CNNM2 UBE2Z
Weight 1.19 1 1 3.0 0.00 1.00000 CNNM2
Impedance of arm (right) 2.86 4 1 3.0 0.56 0.44005 CNNM2 FLJ12825 SLC4A7 TMEM106C
Arm fat percentage (right) 2.58 3 1 3.0 0.00 1.00000 CNNM2 SLC4A7 UBE2Z
Trunk fat-free mass 1.95 4 0 0.0 -0.42 0.57819 CNNM2 SLC4A7 TMEM106C UBE2Z
Hip circumference 1.06 1 1 3.0 0.00 1.00000 CNNM2
Father's age at death 2.96 1 0 0.0 0.00 1.00000 FES
Worrier / anxious feelings 2.61 1 1 3.0 0.00 1.00000 CNNM2
Frequency of tiredness / lethargy in last 2 weeks 1.98 1 0 0.0 0.00 1.00000 UBE2Z
Forced expiratory volume in 1-second (FEV1) 0.83 1 0 0.0 0.00 1.00000 UBE2Z
Medication: Cholesterol lowering 5.39 3 1 3.0 0.00 1.00000 FES PIGV UBE2Z
Lung cancer (father) 2.31 1 0 0.0 0.00 1.00000 FES
Illnesses of mother 13.05 5 2 6.1 -0.99 0.00181 FES PIGV SLC4A7 TMEM106C UBE2Z
Impedance of arm (left) 2.58 4 1 3.0 0.53 0.47402 CNNM2 FLJ12825 SLC4A7 TMEM106C
Arm fat mass (right) 1.69 2 0 0.0 0.00 1.00000 CNNM2 UBE2Z
Trunk predicted mass 1.90 3 1 3.0 0.00 1.00000 CNNM2 SLC4A7 TMEM106C
Standing height 2.14 3 1 3.0 0.00 1.00000 PIGV SLC4A7 UBE2Z
Breastfed as a baby 3.30 2 0 0.0 0.00 1.00000 FES UBE2Z
Tense / 'highly strung' 1.97 1 0 0.0 0.00 1.00000 CNNM2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.28 1 0 0.0 0.00 1.00000 CNNM2
Hair/balding pattern: Pattern 4 1.03 1 0 0.0 0.00 1.00000 FES
Birth weight of first child 5.05 2 1 3.0 0.00 1.00000 CNNM2 FES
Peak expiratory flow (PEF) 1.50 1 0 0.0 0.00 1.00000 UBE2Z
Blood clot in the leg (DVT) 1.38 1 0 0.0 0.00 1.00000 PIGV
Headache pain in last month 1.22 1 0 0.0 0.00 1.00000 FES
Medication for cholesterol, blood pressure or diabetes 10.12 4 2 6.1 -0.99 0.01208 FES PIGV SLC4A7 UBE2Z
Gout (self-reported) 2.26 1 0 0.0 0.00 1.00000 PIGV
Hypothyroidism/myxoedema (self-reported) 0.78 1 0 0.0 0.00 1.00000 UBE2Z
Medication: Amlodipine 7.95 4 1 3.0 0.99 0.00960 C6orf174 FES SLC4A7 UBE2Z
Birth weight 4.03 2 2 6.1 0.00 1.00000 CNNM2 FES
High blood pressure (siblings) 8.13 5 1 3.0 1.00 0.00015 C6orf174 FES PIGV SLC4A7 UBE2Z
Forced vital capacity (FVC), Best measure 0.61 1 0 0.0 0.00 1.00000 UBE2Z
Body fat percentage 1.91 4 0 0.0 0.93 0.07288 C6orf174 FLJ12825 SLC4A7 UBE2Z
Leg fat percentage (right) 1.62 1 0 0.0 0.00 1.00000 UBE2Z
Arm fat-free mass (right) 1.48 3 0 0.0 0.00 1.00000 CNNM2 SLC4A7 TMEM106C
Comparative body size at age 10 1.38 1 0 0.0 0.00 1.00000 CNNM2
Worry too long after embarrassment 2.18 1 0 0.0 0.00 1.00000 UBE2Z
Seen a psychiatrist for nerves, anxiety, tension or depression 1.67 1 0 0.0 0.00 1.00000 CNNM2
Qualifications: College or University degree 0.77 1 0 0.0 0.00 1.00000 UBE2Z
Medication: Blood pressure 14.03 6 2 6.1 0.95 0.00346 C6orf174 CNNM2 FES SLC4A7 TMEM106C UBE2Z
Angina (self-reported) 6.55 3 1 3.0 0.00 1.00000 CNNM2 FES PIGV
Migraine (self-reported) 1.84 1 0 0.0 0.00 1.00000 CNNM2
Medication: Allopurinol 2.46 1 0 0.0 0.00 1.00000 PIGV
Mean time to correctly identify matches 2.03 1 0 0.0 0.00 1.00000 FES
Heart disease (mother) 4.16 1 0 0.0 0.00 1.00000 FES
Whole body fat mass 1.43 2 0 0.0 0.00 1.00000 CNNM2 UBE2Z
Leg fat mass (right) 1.37 2 0 0.0 0.00 1.00000 CNNM2 UBE2Z
Arm predicted mass (right) 1.50 3 0 0.0 0.00 1.00000 CNNM2 SLC4A7 TMEM106C
Pulse rate, automated reading 1.16 2 0 0.0 0.00 1.00000 CNNM2 SLC4A7
Alcohol intake frequency. 1.56 1 0 0.0 0.00 1.00000 UBE2Z
Comparative height size at age 10 1.79 3 0 0.0 0.00 1.00000 CNNM2 PIGV UBE2Z
Suffer from 'nerves' 1.94 1 0 0.0 0.00 1.00000 CNNM2
Overall health rating 1.54 1 0 0.0 0.00 1.00000 UBE2Z
Medication: Aspirin 6.48 2 1 3.0 0.00 1.00000 FES UBE2Z
Hypertension (Self-reported) 16.60 7 6 18.2 0.95 0.00102 C6orf174 CNNM2 FES FLJ12825 PIGV SLC4A7 UBE2Z
Illnesses of father: Heart disease 6.68 2 1 3.0 0.00 1.00000 CNNM2 FES
Whole body fat-free mass 1.86 3 1 3.0 0.00 1.00000 CNNM2 SLC4A7 TMEM106C
Leg fat-free mass (right) 2.12 4 1 3.0 -0.55 0.44686 CNNM2 FES SLC4A7 TMEM106C
Arm fat percentage (left) 2.39 3 1 3.0 0.00 1.00000 CNNM2 SLC4A7 UBE2Z
Diabetes diagnosed by doctor 2.56 1 0 0.0 0.00 1.00000 UBE2Z
Mouth/teeth dental problems: Mouth ulcers 1.33 1 0 0.0 0.00 1.00000 SLC4A7
Medication for cholesterol 7.30 5 0 0.0 0.48 0.40803 C6orf174 CNNM2 FES PIGV SLC4A7
Breast cancer (self-reported) 3.35 1 1 3.0 0.00 1.00000 SLC4A7
Medication: Aspirin 6.53 2 1 3.0 0.00 1.00000 FES UBE2Z
Illnesses of father: None of the above (group 1) 7.13 3 1 3.0 0.00 1.00000 CNNM2 FES UBE2Z
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.21 1 0 0.0 0.00 1.00000 C6orf174
Whole body water mass 1.79 3 1 3.0 0.00 1.00000 CNNM2 SLC4A7 TMEM106C
Leg predicted mass (right) 2.14 4 1 3.0 -0.56 0.44377 CNNM2 FES SLC4A7 TMEM106C
Arm fat mass (left) 1.63 2 0 0.0 0.00 1.00000 CNNM2 UBE2Z
Average weekly champagne plus white wine intake 2.54 1 0 0.0 0.00 1.00000 UBE2Z
Medication: Blood pressure 12.69 5 5 15.2 0.79 0.11410 C6orf174 CNNM2 FES PIGV SLC4A7
High cholesterol (Self-reported) 4.63 2 1 3.0 0.00 1.00000 FES PIGV
Medication: Bendroflumethiazide 9.60 5 1 3.0 -0.14 0.82180 C6orf174 FES FLJ12825 PIGV SLC4A7
Medication: Lisinopril 5.03 3 0 0.0 0.00 1.00000 FES PIGV SLC4A7
Medication: Atorvastatin 2.74 1 0 0.0 0.00 1.00000 PIGV
Illnesses of father: High blood pressure 10.14 3 1 3.0 0.00 1.00000 FES FLJ12825 SLC4A7
Ever smoked 1.03 1 0 0.0 0.00 1.00000 FES
Basal metabolic rate 1.59 2 1 3.0 0.00 1.00000 CNNM2 SLC4A7
Leg fat percentage (left) 1.64 1 0 0.0 0.00 1.00000 UBE2Z
Arm fat-free mass (left) 1.47 3 0 0.0 0.00 1.00000 CNNM2 SLC4A7 TMEM106C
Number of operations (self-reported) 1.60 1 0 0.0 0.00 1.00000 SLC4A7
Irritability 2.07 1 0 0.0 0.00 1.00000 PIGV
Risk taking 1.64 1 0 0.0 0.00 1.00000 FES
Diastolic blood pressure, automated reading 9.79 5 3 9.1 0.97 0.00705 C6orf174 CNNM2 FES PIGV UBE2Z
Vascular/heart problems diagnosed by doctor 17.36 6 6 18.2 -0.98 0.00041 C6orf174 CNNM2 FES PIGV SLC4A7 UBE2Z
Cholesterol lowering medication 4.50 1 1 3.0 0.00 1.00000 PIGV
Heart attack/myocardial infarction (self-reported) 4.34 2 0 0.0 0.00 1.00000 CNNM2 FES
Deep venous thrombosis (DVT) (self-reported) 1.47 1 0 0.0 0.00 1.00000 PIGV
Heart disease (siblings) 3.76 2 0 0.0 0.00 1.00000 CNNM2 FES
Impedance of whole body 3.20 5 2 6.1 0.04 0.94788 CNNM2 FLJ12825 SLC4A7 TMEM106C UBE2Z
Leg fat mass (left) 1.38 2 0 0.0 0.00 1.00000 CNNM2 UBE2Z
Arm predicted mass (left) 1.50 3 0 0.0 0.00 1.00000 CNNM2 SLC4A7 TMEM106C

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.43
GTEx Adipose Visceral Omentum 1 0.0491 1.43
GTEx Adrenal Gland 0 0.0000 1.44
GTEx Artery Aorta 1 0.0336 1.47
GTEx Artery Coronary 0 0.0000 1.37
GTEx Artery Tibial 1 0.0266 1.45
GTEx Brain Caudate basal ganglia 0 0.0000 1.45
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.44
GTEx Brain Cerebellum 0 0.0000 1.43
GTEx Brain Cortex 1 0.0966 1.47
GTEx Brain Frontal Cortex BA9 0 0.0000 1.44
GTEx Brain Hippocampus 0 0.0000 1.34
GTEx Brain Hypothalamus 0 0.0000 1.36
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.34
GTEx Brain Putamen basal ganglia 0 0.0000 1.32
GTEx Breast Mammary Tissue 0 0.0000 1.36
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.38
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.43
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.44
GTEx Cells Transformed fibroblasts 1 0.0238 1.45
GTEx Colon Sigmoid 0 0.0000 1.35
GTEx Colon Transverse 0 0.0000 1.46
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.40
GTEx Esophagus Mucosa 0 0.0000 1.44
GTEx Esophagus Muscularis 1 0.0309 1.43
GTEx Heart Atrial Appendage 0 0.0000 1.37
GTEx Heart Left Ventricle 0 0.0000 1.48
GTEx Liver 0 0.0000 1.37
GTEx Lung 1 0.0348 1.42
GTEx Muscle Skeletal 1 0.0346 1.44
GTEx Nerve Tibial 0 0.0000 1.39
GTEx Ovary 0 0.0000 1.43
GTEx Pancreas 0 0.0000 1.46
GTEx Pituitary 0 0.0000 1.46
GTEx Prostate 0 0.0000 1.51
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.43
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.43
GTEx Small Intestine Terminal Ileum 0 0.0000 1.51
GTEx Spleen 0 0.0000 1.42
GTEx Stomach 0 0.0000 1.44
GTEx Testis 0 0.0000 1.42
GTEx Thyroid 1 0.0250 1.48
GTEx Uterus 0 0.0000 1.39
GTEx Vagina 0 0.0000 1.52
GTEx Whole Blood 0 0.0000 1.39
METSIM Adipose 1 0.0217 1.39
NTR Blood 0 0.0000 1.36
ROSMAP Brain Pre-frontal Cortex 1 0.0228 1.39
YFS Blood 2 0.0433 1.35
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.40
TCGA Breast Tumor 1 0.1304 1.24
TCGA Breast Normal 2 0.0475 1.35
TCGA Ovarian Tumor 1 0.0342 1.29
TCGA Prostate Tumor 2 0.0578 1.42