Hub : Genes

PCCA

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Sigmoid	0.2790	0.0810	1.8e-04	0.034	NA	0.076	NA	0.063	2.3e-02	NA	1.2e-03	NA	2.9e-03
2	GTEx	Esophagus Muscularis	0.1870	0.0560	1.4e-04	-0.002	NA	0.029	NA	0.007	4.8e-01	NA	7.0e-03	NA	1.1e-01
3	GTEx	Stomach	0.1950	0.0740	5.9e-03	0.078	NA	0.058	NA	0.098	1.4e-04	NA	9.7e-04	NA	2.0e-05
4	YFS	Blood	0.0514	0.0132	6.1e-08	0.037	0.023	0.035	0.035	0.039	4.2e-12	3.1e-08	1.4e-11	1.7e-11	8.9e-13
5	TCGA	Thyroid Carcinoma	0.0580	0.0300	3.6e-03	0.005	0.022	0.014	NA	0.016	1.1e-01	2.8e-03	1.4e-02	NA	9.5e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.7	1.1	3.8	-0.4	0.7	-0.1	2.0	-1.1
Bipolar Disorder or Schizophrenia	0.5	1.2	3.0	-1.7	-0.7	-0.8	0.2	-1.4
Depressed Affect (Nagel 2018)	0.7	1.5	3.3	-1.8	-0.3	-1.8	-0.2	-0.8
Depression (Nagel 2018)	0.4	0.6	1.5	-1.2	0.7	-0.1	0.1	-1.0
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	0.6	-0.7	-0.2	-0.2	0.1
Neuroticism (Nagel 2018)	0.5	1.1	3.5	-1.9	-0.7	-0.9	0.9	-0.5
Schizophrenia (2018)	0.8	1.7	3.2	-1.8	-1.4	-0.9	-1.4	-0.9
Schizophrenia vs Biploar Disorder	0.3	0.4	2.0	-0.3	-0.1	-1.4	-0.0	0.0
Worry (Nagel 2018)	0.2	0.4	1.3	-1.1	0.2	0.8	0.3	-0.2
Alzheimer’s Disease (in mother)	0.4	0.5	2.0	0.0	0.4	-1.4	0.6	0.3
Alzheimer’s Disease (in father)	0.7	0.7	1.5	0.8	-0.6	-0.2	-1.1	1.2
Alzheimer’s Disease (including proxy)	0.9	1.2	3.1	1.1	0.4	-1.8	-0.0	1.3
Crohns Disease (2017)	0.6	1.4	3.2	-1.1	-0.3	1.8	1.4	-0.6
Irritable Bowel Disease (IBD)	0.9	2.2	5.3	-1.2	0.1	2.3	2.0	-0.6
Ulcerative Colitis (UC)	0.8	1.5	3.8	-0.6	0.5	2.0	1.5	-0.8
Major Depression (MDD)	1.1	1.3	4.7	-2.2	-0.7	0.1	0.8	-1.0
Reaction Time	0.9	1.7	4.1	-1.1	2.0	-1.7	-0.8	0.1
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.3	-0.5	-1.1	1.1	1.1	-0.5
Breast Cancer	1.5	3.6	9.3	2.3	0.7	1.1	1.2	3.0
Ovarian Cancer	0.9	1.2	2.5	1.6	0.2	1.6	0.2	1.0
Prostate Cancer	0.3	0.4	1.0	0.3	-0.8	0.5	1.0	0.3
Age at First Birth	2.1	3.0	5.6	2.4	1.9	1.9	-0.1	1.5
Bipolar Disorder (2011)	0.5	0.4	1.0	0.3	-0.5	-0.8	0.5	1.0
Body Mass Index (BMI) (2010)	0.9	1.2	2.9	0.5	1.7	0.9	-0.8	1.3
Coronary Artery Disease (CAD)	0.5	0.6	1.7	-0.6	-0.4	0.5	1.3	-0.9
Crohns Disease (2012)	0.3	0.5	1.2	-0.2	1.0	0.7	1.1	0.2
Mean Putamen Volume	0.2	0.3	0.9	-0.5	-0.5	-0.1	0.1	-0.9
Fasting Glucose	0.2	0.3	0.9	0.0	1.0	-0.6	0.1	-0.1
HbA1C	0.5	0.6	1.1	0.8	-0.2	-1.1	-0.6	-0.9
HDL Cholesterol	0.3	0.5	1.2	0.9	-0.4	-0.6	0.3	-1.1
LDL Cholesterol	0.2	0.4	0.8	-0.8	-0.6	-0.9	-0.2	-0.2
Lupus	1.4	2.1	3.2	-1.5	-1.5	-1.8	1.7	-0.0
Neuroticism (2016)	0.7	1.0	2.4	-1.5	-1.5	-0.1	0.5	-0.7
Primary Biliary Cirrhosis	0.2	0.2	0.5	0.7	0.5	-0.4	-0.0	0.4
Rheumatoid Arthritis	1.0	1.3	3.5	-1.0	-0.8	-1.9	-0.8	-0.9
Schizophrenia (2014)	0.3	0.8	1.6	-0.6	0.3	-1.2	-1.3	-0.5
Triglycerides	0.4	0.7	1.5	-1.0	-0.5	-0.2	-0.8	1.2
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.5	-1.2	-1.3	1.1	0.5	-1.6
Ulcerative Colitis	0.5	0.7	1.6	-0.4	0.7	1.3	1.2	-0.3
Blood Eosinophil Count	0.1	0.5	1.4	-1.2	-0.1	0.3	0.3	1.0
Blood Platelet Count	0.5	6.0	13.7	-2.3	-2.9	1.3	0.8	-3.7
Blood Red Count	0.1	0.8	2.8	0.5	-0.3	0.4	1.7	-0.7
Blood White Count	0.6	4.2	14.2	-1.4	-1.6	1.2	1.0	-3.8
Heel T-Score	0.2	1.6	2.6	1.4	-1.6	-0.7	1.3	1.2
BMI	0.4	2.1	4.7	-1.2	-1.5	1.2	2.2	-1.0
Height	0.3	6.7	9.8	3.1	3.0	1.2	-2.9	2.0
Waist Hip Ratio (WHR)	1.8	8.2	30.3	-2.4	-1.2	1.5	1.1	-5.5
Systolic Blood Pressure	0.3	1.3	5.9	-0.3	0.3	0.6	0.2	-2.4
Smoking Status	5.3	12.8	24.3	-4.9	-4.2	-0.9	3.7	-2.7
Allergy or Eczema	0.1	0.2	1.0	-1.0	-0.2	0.1	-0.2	0.3
Cardiovascular Disease	1.2	3.9	11.8	-3.4	-1.8	0.6	0.5	-2.0
Hypothyroidism (self reported)	0.2	0.5	1.2	0.1	-0.4	1.1	-0.2	-0.9
Respiratory disease	0.4	1.0	2.9	-0.4	-0.6	0.7	1.0	-1.7
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.1	-0.4	-0.3	0.3	-0.3	1.0
Lung FEV1/FVC ratio	0.1	0.7	1.1	1.1	0.8	-0.9	-0.8	0.2
Lung FVC	0.5	2.8	11.0	0.9	-0.2	-0.0	1.4	3.3
Neuroticism	0.3	0.7	2.3	-1.5	-0.8	-0.3	0.8	-0.1
Chronotype (morning person)	0.9	2.2	3.8	0.3	1.4	-1.8	-1.4	2.0
Hair Pigment	0.1	3.4	8.3	-0.8	-1.9	2.0	2.9	0.7
Tanning	0.2	2.4	4.2	-1.3	-2.0	1.4	2.1	0.3
Hand grip strength (left)	0.3	0.7	2.1	0.9	0.4	0.6	0.0	1.4
Number of treatments/medications taken	0.8	1.4	2.0	-1.0	-1.4	1.4	-1.1	0.9
Average weekly spirits intake	0.6	0.8	2.2	0.2	-0.7	-1.0	1.5	0.2
Sensitivity / hurt feelings	0.5	0.8	1.7	-1.0	-0.4	-0.7	1.3	0.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.2	-0.6	1.1	0.1	-0.5	-0.6
Hearing difficulty/problems: Yes	0.4	0.6	2.0	0.3	-0.8	0.7	0.2	-1.4
Relative age of first facial hair	0.3	0.7	3.2	-0.3	0.0	-1.8	-0.2	0.1
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.1	1.4	0.3	1.4	-1.3	0.6
Ever used hormone-replacement therapy (HRT)	1.1	1.4	4.8	0.6	-0.2	-2.2	-1.2	-0.5
Ever had hysterectomy (womb removed)	0.7	0.8	3.2	-0.1	-0.6	-1.8	0.3	-0.7
Systolic blood pressure, automated reading	0.1	0.2	0.5	0.4	0.3	0.2	0.5	-0.7
Eye problems/disorders: Diabetes related eye disease	2.3	2.6	4.9	2.2	1.7	1.5	-1.0	1.3
Angina	1.6	2.1	7.4	0.5	0.5	1.6	-2.7	-0.0
Medication for hormone replacement therapy	0.4	0.4	1.2	0.0	-0.8	-1.1	-0.6	-0.1
Vitamin and mineral supplements	1.2	1.6	4.6	-0.5	-0.7	2.1	1.0	-1.3
Supplements: Zinc	1.5	1.7	3.4	1.1	1.6	0.8	-0.7	1.8
Medication: Co-codamol	0.7	0.8	2.0	0.2	-1.4	-0.5	-1.3	0.6
Medication: Metformin	0.2	0.3	0.7	-0.6	-0.3	0.1	0.8	0.5
Diabetes (father)	0.4	0.5	1.0	-0.7	0.4	-0.2	1.0	0.9
Diabetes (mother)	0.2	0.3	0.7	-0.5	0.3	0.3	0.6	-0.8
Severe depression (siblings)	1.6	1.8	7.6	0.2	2.8	-0.4	-0.7	0.9
Pack years adult smoking proportion	0.4	0.6	1.1	-0.8	-0.6	-0.9	-0.5	-1.0
Impedance of leg (right)	0.6	2.9	8.0	-2.0	-1.5	-0.6	0.5	-2.8
Leg fat-free mass (left)	0.4	2.0	3.1	1.8	1.6	1.4	-0.9	1.2
Trunk fat percentage	0.4	1.4	4.9	-2.2	-0.3	1.0	0.7	-0.9
Hand grip strength (right)	0.5	1.5	4.6	1.3	1.0	0.5	0.0	2.1
Townsend deprivation index at recruitment	2.6	3.6	13.0	-3.6	-2.0	-1.0	-0.3	-0.2
Current tobacco smoking	2.3	3.8	11.2	-3.3	-1.6	-1.9	0.8	-1.0
Average weekly fortified wine intake	2.3	2.7	6.7	1.4	2.2	-2.6	-0.5	0.2
Maternal smoking around birth	3.9	5.6	12.9	-3.6	-2.3	0.4	0.9	-2.9
Fed-up feelings	0.5	0.9	3.3	0.4	0.1	0.5	-1.8	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	3.7	-1.0	0.3	0.7	-0.4	-1.9
Relative age voice broke	0.2	0.4	0.8	-0.1	-0.9	-0.7	0.5	-0.4
Taking other prescription medications	0.1	0.1	0.5	0.1	-0.7	-0.3	-0.2	0.1
Age when periods started (menarche)	0.8	2.0	7.4	1.1	1.1	-0.2	-0.6	2.7
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	3.5	0.5	-0.6	-1.9	0.9	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.5	0.8	-0.5	-0.3	0.9	1.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.3	1.2	-0.4	0.7	0.4	0.1
Qualifications: CSEs or equivalent	3.0	4.0	8.3	-2.9	-1.6	-0.1	1.2	-2.8
Serious illness, injury or assault to yourself	0.3	0.4	0.7	-0.0	-0.7	0.7	-0.9	-0.4
High blood pressure	0.3	0.8	3.4	-1.8	-0.1	0.6	-0.3	-0.2
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.4	-0.0	0.2	0.3	-0.7	-0.2
Multivitamins +/- minerals	1.2	1.5	5.5	-1.0	-0.6	-2.3	-0.4	0.7
Stomach or abdominal pain in last month	0.9	1.1	3.2	-0.6	-1.3	0.2	-0.2	-1.8
Supplements: Glucosamine	0.9	1.2	5.1	0.7	0.5	-0.4	-2.2	0.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.8	-0.9	-0.6	0.4	0.1	0.3
Medication: Atenolol	0.4	0.5	1.5	0.6	0.5	-0.4	0.1	1.2
Medication: Levothyroxine sodium	0.3	0.5	1.8	-0.4	-1.4	0.7	0.3	0.4
Sitting height	0.2	1.3	5.5	2.4	-0.3	0.2	-1.0	0.3
Chronic bronchitis/emphysema (father)	2.7	3.2	8.5	-0.9	-2.9	-0.7	0.4	-2.5
High blood pressure (mother)	0.6	0.8	3.1	-0.1	-0.8	1.8	-0.5	0.3
Body mass index (BMI)	0.2	1.0	2.4	-1.5	-0.4	0.6	1.2	-0.9
Impedance of leg (left)	0.6	2.9	7.2	-2.0	-1.8	0.1	0.5	-2.7
Leg predicted mass (left)	0.4	2.1	3.5	1.9	1.7	1.3	-1.0	1.3
Trunk fat mass	0.2	0.7	1.7	-1.2	0.1	1.3	0.2	-0.5
Waist circumference	0.7	2.6	7.4	-1.7	-0.5	1.4	0.8	-2.7
Number of incorrect matches in round	0.4	0.6	1.9	1.0	-0.3	0.1	-0.1	1.4
Past tobacco smoking	5.0	9.2	16.0	3.1	3.7	-1.4	-4.0	2.0
Alcohol usually taken with meals	7.7	12.5	25.0	5.0	4.5	0.1	-2.7	3.2
Nervous feelings	0.3	0.6	1.3	-0.8	-0.0	0.5	1.2	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.2	-0.6	0.2	-1.1	-0.5	-0.3
Hearing difficulty/problems with background noise	0.2	0.4	0.7	-0.5	-0.5	-0.9	0.8	0.3
Hair/balding pattern: Pattern 2	6.8	8.7	32.4	-2.6	-2.0	-0.0	5.7	-0.6
Had menopause	0.4	0.6	1.7	-0.3	0.9	-1.3	-0.4	0.2
Had other major operations	0.5	0.6	2.5	-0.1	-0.1	-1.6	0.6	0.2
Forced vital capacity (FVC)	0.9	3.6	9.8	2.5	1.2	0.1	0.6	3.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.8	0.7	-1.0	-0.4	0.5	1.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.0	-0.3	0.7	0.9	-0.8	1.0
Qualifications: None of the above	1.9	4.1	8.5	-2.9	-2.7	0.0	1.1	-1.9
Financial difficulties in last 2 years	2.0	2.6	7.3	-2.7	-1.3	-1.0	0.6	-1.7
Mouth/teeth dental problems	0.8	1.3	4.1	-0.0	-0.2	1.5	0.3	-2.0
Heart attack	0.4	0.5	1.4	0.1	0.3	1.2	-0.9	0.4
Allergy	0.4	0.8	2.6	-0.4	-0.7	-0.7	1.6	0.6
Pain all over the body in last month	0.6	0.7	2.3	-0.9	0.1	-0.1	0.3	1.5
Diabetes (self-reported)	0.6	0.9	3.6	-0.3	-0.1	-0.7	0.4	1.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	-0.4	0.8	0.7	-0.1	0.4
Medication: Ramipril	1.3	1.7	6.6	-0.9	0.5	2.6	0.0	0.8
Medication: Simvastatin	0.7	1.0	2.9	-1.1	-0.6	-0.4	0.3	-1.7
Fluid intelligence score	0.3	0.7	1.4	0.7	0.8	1.2	0.9	0.0
Illnesses of siblings	0.3	0.5	1.5	-1.2	-0.3	-0.6	0.3	0.5
Neuroticism score	0.2	0.5	1.9	-1.4	-0.2	-0.4	-0.5	-0.5
Weight	0.1	0.6	2.3	0.2	0.8	1.5	-0.1	-0.2
Impedance of arm (right)	0.1	0.6	2.8	-1.7	0.2	-0.5	-0.1	-0.2
Arm fat percentage (right)	0.4	1.5	5.4	-2.3	-0.4	0.5	1.2	-0.6
Trunk fat-free mass	0.6	3.2	9.8	3.1	1.6	1.1	-1.4	0.7
Hip circumference	0.0	0.2	0.4	-0.4	0.7	0.4	-0.3	-0.2
Time employed in main current job	0.7	0.8	2.2	-1.0	-0.6	1.5	0.5	0.5
Alcohol intake versus 10 years previously	0.9	1.4	2.9	0.7	0.3	1.3	1.3	1.7
Father’s age at death	1.2	1.6	6.4	0.5	1.1	-0.0	-0.3	2.5
Worrier / anxious feelings	0.3	0.6	1.6	-1.3	-0.1	0.4	0.8	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	1.3	-0.8	1.0	-0.4	-0.7	-1.1
Falls in the last year	1.2	1.6	3.7	-1.5	-1.9	-0.8	0.4	-1.2
Hair/balding pattern: Pattern 3	8.3	12.4	42.0	3.0	2.7	-1.5	-6.5	1.3
Number of live births	0.6	0.8	1.6	-0.2	-0.7	1.2	1.3	0.6
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	9.2	2.8	1.4	0.3	0.4	3.0
Pulse rate	1.8	3.1	6.9	-1.5	-2.6	0.2	-0.5	-2.5
Happiness	2.2	2.7	5.9	0.8	2.4	0.1	-2.4	1.2
Noisy workplace	0.3	0.3	1.3	-0.2	1.1	0.6	0.1	0.1
Qualifications: A levels/AS levels or equivalent	2.6	5.7	11.0	3.3	2.9	-0.8	-2.6	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.5	-0.7	-0.5	-0.6	-0.4	-0.5
Mouth/teeth dental problems: Dentures	0.3	0.5	1.6	-0.2	0.0	-1.0	0.2	1.2
Asthma	0.2	0.3	1.0	1.0	-0.3	0.1	-0.1	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	4.2	0.3	-0.2	0.6	-2.1	0.7
Medication: Cholesterol lowering	1.7	2.6	9.1	-1.5	-3.0	0.8	0.8	-0.6
Depression (self-reported)	0.3	0.4	1.0	-0.8	-0.1	0.5	0.1	1.0
Medication: Lansoprazole	0.3	0.4	0.9	-1.0	-0.4	0.1	0.8	0.1
Prospective memory result	1.1	1.3	2.2	1.1	1.1	1.2	-1.5	0.6
Lung cancer (father)	0.4	0.5	1.2	0.4	0.5	-0.8	0.6	-1.1
Illnesses of mother	0.5	0.6	2.1	-0.2	1.0	-1.4	-0.2	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	8.2	2.9	1.3	0.3	1.1	2.1
Pulse wave Arterial Stiffness index	1.0	1.2	2.2	0.6	1.1	-0.9	-1.5	1.1
Impedance of arm (left)	0.1	0.5	2.6	-1.6	0.2	0.0	-0.1	-0.3
Arm fat mass (right)	0.2	0.9	2.6	-1.6	0.0	0.8	0.9	-0.7
Trunk predicted mass	0.5	3.1	9.5	3.1	1.5	1.1	-1.4	0.7
Standing height	0.6	6.1	12.8	3.6	2.3	1.7	-2.8	1.2
Length of working week for main job	0.9	1.0	4.1	0.6	2.0	-0.2	0.1	-0.5
Exposure to tobacco smoke at home	0.6	0.6	1.5	0.8	0.7	0.3	-0.6	1.2
Breastfed as a baby	0.6	0.7	1.7	0.8	1.3	-0.7	0.6	0.7
Tense / ‘highly strung’	1.0	1.7	3.2	0.5	1.7	0.3	-1.5	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.2	-1.5	-1.2	-1.2	0.4	-0.4
Hair/balding pattern: Pattern 4	2.0	4.8	11.8	-1.6	-3.4	1.3	2.4	-1.6
Birth weight of first child	0.3	0.6	1.7	-0.2	-0.4	1.3	0.9	0.2
Peak expiratory flow (PEF)	0.3	0.7	2.1	1.4	0.5	-0.2	0.6	1.0
Pulse wave reflection index	1.8	2.2	7.0	0.8	2.6	0.5	-0.4	1.7
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.4	-1.2	-0.2	0.0	0.7	1.1
Loud music exposure frequency	1.1	1.2	4.9	-0.8	-0.1	-0.6	2.2	0.2
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	6.9	2.6	2.2	0.0	-1.2	1.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	0.2	-0.0	-0.6	0.6	-0.6
Blood clot in the leg (DVT)	1.0	1.3	2.2	-1.2	-0.2	-1.4	-0.8	-1.5
Medication: Paracetamol	1.1	1.8	7.3	-1.2	-0.1	-0.2	-2.7	-0.8
Headache pain in last month	0.5	0.8	3.5	-0.2	0.3	-0.5	0.6	1.9
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	2.4	0.9	1.5	-1.3	-0.1	0.2
Glaucoma (self-reported)	0.7	0.8	2.0	0.9	-0.6	-0.5	-0.8	1.4
Gout (self-reported)	1.7	2.3	5.8	-2.4	-2.0	-0.1	0.3	-1.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.7	-0.4	-1.4	1.6	-0.2	-0.8
Medication: Amlodipine	0.9	1.3	4.8	-2.2	-0.7	-0.4	-0.0	-0.9
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.6	0.3	-0.1	-0.8	0.4	0.1
Birth weight	0.1	0.2	0.6	0.1	-0.3	0.3	0.8	-0.0
Chronic bronchitis/emphysema (mother)	1.7	2.0	6.0	-1.7	-0.6	0.6	-0.4	-2.5
High blood pressure (siblings)	1.2	1.7	4.6	2.1	1.2	0.4	-1.5	0.6
Forced vital capacity (FVC), Best measure	1.0	3.6	9.4	3.1	1.6	0.3	0.8	2.3
Body fat percentage	0.5	1.8	5.5	-2.4	-0.6	0.9	1.1	-1.2
Leg fat percentage (right)	0.9	3.4	7.6	-2.8	-1.3	0.7	1.0	-2.5
Arm fat-free mass (right)	0.4	2.0	5.3	2.3	1.2	1.6	-0.9	0.2
Exposure to tobacco smoke outside home	0.2	0.3	1.1	-1.0	-0.4	0.2	-0.3	-0.4
Comparative body size at age 10	0.7	1.9	4.7	-0.5	2.2	-0.3	-1.3	1.7
Number of full brothers	1.0	1.3	4.4	-0.4	-0.6	0.8	1.0	-2.1
Worry too long after embarrassment	0.1	0.1	0.3	-0.5	-0.2	-0.6	0.1	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.3	-0.3	0.4	0.8	-0.7
Wheeze or whistling in the chest in last year	0.7	1.3	3.9	-1.0	-0.7	-0.3	-0.9	-2.0
Number of children fathered	0.7	0.8	2.3	1.5	0.3	0.9	-0.8	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	4.6	0.5	-0.5	0.7	-1.8	-2.1
Age at first live birth	0.5	1.0	2.2	1.2	0.6	1.5	-0.6	0.6
Pulse wave peak to peak time	0.9	1.0	2.2	-0.3	-1.0	1.0	1.5	-0.9
Health satisfaction	0.9	1.1	3.9	-0.3	0.9	1.0	-2.0	0.2
Shortness of breath walking on level ground	0.5	0.6	2.7	-0.0	-0.1	0.3	0.1	-1.6
Qualifications: College or University degree	4.2	13.2	24.2	4.5	4.9	0.0	-4.7	0.5
Eye problems/disorders: None of the above	3.9	4.6	9.0	-3.0	-2.7	-0.5	2.2	-1.2
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.7	-0.8	-0.4	0.2	0.7	0.4
Emphysema/chronic bronchitis	2.4	2.7	8.6	1.2	1.0	0.7	-2.9	-1.5
Medication for pain relief, constipation, heartburn	1.2	2.1	5.8	1.5	1.2	-0.8	2.4	-0.5
Neck or shoulder pain in last month	1.7	2.4	3.8	0.9	1.8	-2.0	-1.8	1.1
Medication: Blood pressure	0.5	0.9	2.7	-0.8	-0.7	1.7	-0.9	0.0
Angina (self-reported)	1.6	2.1	7.2	0.5	0.5	1.6	-2.7	-0.0
Migraine (self-reported)	0.6	0.7	0.9	-0.8	-0.9	-0.7	0.9	0.8
Medication: Ibuprofen	0.7	0.8	2.4	-0.4	-0.6	0.9	-1.6	0.8
Medication: Allopurinol	2.7	3.6	10.0	-3.2	-2.3	0.6	0.7	-1.3
Medication: Omeprazole	0.3	0.4	1.2	0.5	-0.5	0.2	0.1	-1.1
Medication: Seretide 50 evohaler	0.7	0.8	1.9	0.5	-1.0	1.4	-0.6	-0.4
Mean time to correctly identify matches	0.9	1.6	3.4	-1.6	1.1	-1.8	-1.0	0.1
Heart disease (mother)	0.4	0.5	1.3	-0.1	-0.1	0.6	0.8	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.2	-1.6	-0.6	-0.3	0.9	1.8
Whole body fat mass	0.2	0.8	1.7	-1.2	0.1	1.3	0.4	-0.7
Leg fat mass (right)	0.2	0.9	1.8	-1.3	-0.4	0.9	0.4	-1.4
Arm predicted mass (right)	0.3	1.7	4.6	2.1	0.9	1.4	-1.0	0.2
Pulse rate, automated reading	2.1	6.9	15.7	-2.8	-3.3	-0.1	-0.1	-4.0
Alcohol intake frequency.	0.1	0.3	0.6	0.5	-0.6	-0.1	0.8	0.2
Comparative height size at age 10	0.1	0.3	1.0	0.3	0.8	-0.0	-1.0	0.2
Number of full sisters	1.0	1.2	3.6	0.4	-1.5	-1.9	-0.0	-0.2
Suffer from ‘nerves’	1.1	1.7	3.5	-1.5	-0.5	0.9	1.9	1.3
Overall health rating	0.3	0.7	1.8	-0.7	-1.3	-0.3	-0.6	-0.9
Chest pain or discomfort	0.1	0.2	0.6	0.2	0.4	-0.1	-0.4	-0.8
Had major operations	0.4	0.5	1.4	-0.1	-0.8	1.2	-0.0	0.6
Age at last live birth	0.8	1.2	2.2	1.5	0.4	1.5	0.5	1.1
Family relationship satisfaction	1.5	1.9	6.1	0.2	1.7	-0.4	-2.5	0.4
Leg pain on walking	0.8	1.0	2.2	-0.4	-1.2	-0.3	1.5	1.0
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	4.0	-0.3	-2.0	-0.9	0.8	0.8
Commuting to job workplace: Car/motor vehicle	1.4	1.6	4.6	-0.1	-2.1	1.1	0.7	-1.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	1.7	1.3	1.2	0.9	0.7	1.3
Medication: Aspirin	0.6	0.8	1.8	-0.3	-0.4	0.8	-1.2	1.3
Supplements: Vitamin C	2.0	2.3	5.6	2.4	1.9	1.0	-0.7	1.0
Knee pain experienced in last month	1.0	1.6	3.5	-1.3	-1.9	-0.2	1.0	-1.4
Hypertension (Self-reported)	0.2	0.5	1.7	-1.3	0.1	0.6	-0.5	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.9	0.0	0.3	-0.6	-1.0	0.2
Illnesses of father: Heart disease	0.5	0.7	2.8	-1.7	-0.6	0.4	0.4	-0.3
Illnesses of siblings: Diabetes	0.5	0.6	1.2	-1.1	-0.6	0.2	0.9	-0.7
Smoking status: Previous	5.1	7.7	19.4	-2.2	-3.5	0.9	4.4	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.6	-0.2	0.6	1.3	0.4	0.3
Whole body fat-free mass	0.4	2.5	6.8	2.6	1.5	1.2	-1.1	0.9
Leg fat-free mass (right)	0.4	2.4	3.8	2.0	1.7	1.5	-1.0	1.3
Arm fat percentage (left)	0.4	1.7	6.0	-2.4	-0.5	0.7	1.1	-0.8
Average weekly red wine intake	5.2	7.6	14.4	3.8	3.3	-1.1	-1.6	3.0
Handedness (chirality/laterality): Left-handed	1.3	1.6	6.3	2.5	0.9	0.7	-0.2	-0.2
Mood swings	0.8	1.4	4.3	-1.0	0.1	-2.1	1.0	1.0
Loneliness, isolation	0.7	1.0	3.0	0.3	1.7	-0.0	-1.4	-0.1
Long-standing illness, disability or infirmity	0.2	0.3	0.7	0.5	-0.2	0.8	-0.4	0.5
Ever had bowel cancer screening	0.4	0.5	0.9	-0.2	-0.7	0.9	-0.8	0.5
Diabetes diagnosed by doctor	0.2	0.3	1.0	0.0	-0.5	-0.2	-0.5	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	-0.1	0.0	0.4	0.3	0.6
Friendships satisfaction	1.0	1.2	4.1	0.7	2.0	-0.7	-1.0	0.3
Qualifications: nursing, teaching	1.5	2.3	4.3	1.4	1.9	0.7	-2.1	1.1
Commuting to job workplace: Walk	2.4	2.6	8.9	1.2	3.0	-0.3	-1.3	0.9
Eye problems/disorders: Cataract	0.5	0.6	1.4	0.4	1.2	0.8	-0.8	-0.1
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	3.2	1.0	1.2	-1.0	-1.0	1.8
Medication for cholesterol	0.6	1.0	1.9	0.8	-0.9	0.2	1.2	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.2	2.9	-0.5	-0.2	-1.7	-1.1	-1.3
Back pain experienced in last month	0.9	1.3	3.1	-0.4	-0.6	-0.2	-1.8	-1.7
Mineral and other dietary supplements	1.1	1.5	2.6	-1.6	-0.6	0.2	1.6	-1.5
Breast cancer (self-reported)	2.8	3.3	5.4	-1.5	-2.1	-0.3	2.3	-2.1
Asthma (self-reported)	0.2	0.3	1.1	1.1	-0.2	-0.1	-0.1	-0.7
Osteoporosis (self-reported)	2.3	2.8	8.9	0.6	1.0	-0.6	-1.8	3.0
Osteoarthritis (self-reported)	1.1	1.4	2.0	-1.4	-1.1	1.3	0.7	-1.3
Medication: Aspirin	0.7	0.9	1.7	-0.5	-0.3	1.0	-1.2	1.3
Medication: Gliclazide	0.8	0.9	2.5	-0.9	0.0	0.7	-0.7	1.6
Illnesses of father: None of the above (group 1)	1.4	1.8	5.0	2.2	1.4	-0.2	-1.4	0.1
Smoking status: Current	1.9	3.1	10.1	-3.2	-1.1	-1.7	0.2	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.8	8.2	2.9	2.0	-0.6	0.6	2.5
Whole body water mass	0.5	2.8	6.9	2.6	1.7	1.3	-1.2	0.9
Leg predicted mass (right)	0.4	2.3	3.8	1.9	1.6	1.6	-0.9	1.4
Arm fat mass (left)	0.2	1.0	2.5	-1.6	-0.2	0.9	0.7	-0.9
Number of self-reported non-cancer illnesses	0.3	0.5	1.1	-1.1	-1.0	0.3	-0.2	-0.7
Average weekly champagne plus white wine intake	0.6	0.8	2.9	0.4	0.2	0.9	0.1	-1.7
Miserableness	0.5	0.8	2.0	-1.4	-0.3	-1.1	-0.7	-0.5
Guilty feelings	1.6	2.4	8.5	0.3	1.4	-0.9	-2.9	0.8
Wears glasses or contact lenses	1.6	1.9	4.1	1.3	0.9	-1.0	-2.0	1.4
Ever taken oral contraceptive pill	0.2	0.2	0.7	0.0	0.2	0.1	0.9	0.4
Hearing aid user	1.9	2.1	5.6	2.4	1.2	-0.8	-1.2	1.2
Mother’s age at death	0.1	0.2	0.4	0.6	0.3	0.5	0.0	0.4
Financial situation satisfaction	1.4	1.8	4.7	-2.0	-0.2	0.7	0.1	-2.2
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	0.1	-0.3	0.5	-0.8	0.7
Commuting to job workplace: Public transport	0.5	0.6	1.2	-0.4	1.1	-1.0	0.6	0.4
Eye problems/disorders: Glaucoma	0.7	0.8	2.5	1.0	0.2	-0.3	-1.6	0.7
Medication: Blood pressure	0.8	1.5	3.5	-0.4	1.9	1.6	-1.1	-0.1
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.9	-0.6	-1.7	-0.7	0.6	-1.7
Supplements: Fish oil (including cod liver oil)	1.3	1.7	2.9	1.2	0.8	-1.7	-1.1	1.6
High cholesterol (Self-reported)	1.1	1.9	4.7	-1.9	-1.1	0.1	-0.1	-2.2
Medication: Bendroflumethiazide	0.3	0.5	0.9	-0.7	0.7	0.1	-0.9	-0.9
Medication: Paracetamol	1.3	2.0	7.3	-1.1	0.9	0.4	-2.7	-0.5
Medication: Lisinopril	0.3	0.4	0.8	-0.8	0.6	0.5	-0.1	0.9
Medication: Atorvastatin	1.1	1.4	3.7	1.3	0.1	-0.5	-1.9	1.1
Illnesses of father: High blood pressure	0.5	0.6	1.1	1.0	0.6	1.1	-0.5	0.4
Alcohol drinker status: Never	1.3	1.6	3.9	1.1	2.0	-0.4	0.3	1.6
Ever smoked	5.7	10.0	13.8	-3.5	-3.6	2.0	3.7	-2.8
Basal metabolic rate	0.3	1.9	4.1	2.0	1.5	1.4	-0.9	0.6
Leg fat percentage (left)	1.0	3.5	7.9	-2.8	-1.5	1.0	0.9	-2.4
Arm fat-free mass (left)	0.3	1.3	3.4	1.9	1.0	1.2	-0.9	0.0
Number of operations (self-reported)	0.6	1.0	3.4	0.9	-0.7	-1.8	0.2	-0.1
Average weekly beer plus cider intake	8.1	11.7	23.6	-4.9	-4.3	0.7	2.4	-3.2
Irritability	0.4	0.7	2.0	-1.4	-0.8	-0.3	-0.4	-0.9
Risk taking	0.6	0.9	2.8	-0.0	-0.8	-1.7	-0.8	0.7
Ever had prostate specific antigen (PSA) test	1.7	1.9	5.5	2.4	0.5	0.0	-0.7	1.8
Fractured/broken bones in last 5 years	0.6	0.7	1.3	0.5	-0.5	-1.1	0.9	1.0
Age started oral contraceptive pill	1.9	2.3	5.3	2.2	2.3	0.9	-0.9	0.2
Diastolic blood pressure, automated reading	0.3	0.9	1.9	-0.7	-1.4	-0.7	-0.0	-1.3
Ever depressed for a whole week	0.5	0.6	2.2	-1.5	0.0	0.8	-0.5	-0.2
Unable to work because of sickness or disability	0.6	0.8	1.6	-1.2	0.3	0.9	-0.5	-1.2
Commuting to job workplace: Cycle	4.0	4.8	8.8	2.0	1.4	-3.0	-1.2	2.9
Myopia	6.2	9.0	19.2	3.2	2.8	1.5	-4.4	2.4
Vascular/heart problems diagnosed by doctor	0.5	1.3	4.0	2.0	0.4	-1.3	0.6	0.8
Cholesterol lowering medication	1.0	1.5	3.1	-0.7	1.3	-0.6	-1.3	-1.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.9	0.1	-0.8	0.2	-0.3	-1.0
Pain experienced in last month	1.0	1.7	3.6	1.9	1.4	1.4	-0.4	1.0
Supplements: Calcium	1.9	2.1	3.9	0.0	1.2	-2.0	-1.1	2.0
Basal cell carcinoma (self-reported)	1.2	1.4	3.1	-0.1	-1.2	-1.6	1.8	-0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.0	-0.1	0.4	1.0	-0.9	0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.9	-1.4	-0.2	-1.0	-0.2	-1.2
Heart disease (siblings)	0.5	0.6	1.6	0.2	0.1	1.2	0.4	-1.3
Alcohol drinker status: Previous	0.7	0.8	2.3	-1.5	-1.2	-0.2	0.5	-0.4
Pack years of smoking	0.5	0.7	1.1	-0.6	-0.8	-1.1	-0.8	-0.8
Impedance of whole body	0.3	1.5	4.2	-2.1	-0.7	-0.1	0.1	-1.6
Leg fat mass (left)	0.3	1.0	1.8	-1.3	-0.5	1.1	0.4	-1.3
Arm predicted mass (left)	0.4	1.8	5.1	2.3	1.2	1.2	-1.0	0.0