Hub : Genes

PCCA

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Colon Sigmoid 0.2790 0.0810 1.8e-04 0.034 NA 0.076 NA 0.063 2.3e-02 NA 1.2e-03 NA 2.9e-03
2 GTEx Esophagus Muscularis 0.1870 0.0560 1.4e-04 -0.002 NA 0.029 NA 0.007 4.8e-01 NA 7.0e-03 NA 1.1e-01
3 GTEx Stomach 0.1950 0.0740 5.9e-03 0.078 NA 0.058 NA 0.098 1.4e-04 NA 9.7e-04 NA 2.0e-05
4 YFS Blood 0.0514 0.0132 6.1e-08 0.037 0.023 0.035 0.035 0.039 4.2e-12 3.1e-08 1.4e-11 1.7e-11 8.9e-13
5 TCGA Thyroid Carcinoma 0.0580 0.0300 3.6e-03 0.005 0.022 0.014 NA 0.016 1.1e-01 2.8e-03 1.4e-02 NA 9.5e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.7 1.1 3.8 -0.4 0.7 -0.1 2.0 -1.1
Bipolar Disorder or Schizophrenia 0.5 1.2 3.0 -1.7 -0.7 -0.8 0.2 -1.4
Depressed Affect (Nagel 2018) 0.7 1.5 3.3 -1.8 -0.3 -1.8 -0.2 -0.8
Depression (Nagel 2018) 0.4 0.6 1.5 -1.2 0.7 -0.1 0.1 -1.0
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.4 0.6 -0.7 -0.2 -0.2 0.1
Neuroticism (Nagel 2018) 0.5 1.1 3.5 -1.9 -0.7 -0.9 0.9 -0.5
Schizophrenia (2018) 0.8 1.7 3.2 -1.8 -1.4 -0.9 -1.4 -0.9
Schizophrenia vs Biploar Disorder 0.3 0.4 2.0 -0.3 -0.1 -1.4 -0.0 0.0
Worry (Nagel 2018) 0.2 0.4 1.3 -1.1 0.2 0.8 0.3 -0.2
Alzheimer’s Disease (in mother) 0.4 0.5 2.0 0.0 0.4 -1.4 0.6 0.3
Alzheimer’s Disease (in father) 0.7 0.7 1.5 0.8 -0.6 -0.2 -1.1 1.2
Alzheimer’s Disease (including proxy) 0.9 1.2 3.1 1.1 0.4 -1.8 -0.0 1.3
Crohns Disease (2017) 0.6 1.4 3.2 -1.1 -0.3 1.8 1.4 -0.6
Irritable Bowel Disease (IBD) 0.9 2.2 5.3 -1.2 0.1 2.3 2.0 -0.6
Ulcerative Colitis (UC) 0.8 1.5 3.8 -0.6 0.5 2.0 1.5 -0.8
Major Depression (MDD) 1.1 1.3 4.7 -2.2 -0.7 0.1 0.8 -1.0
Reaction Time 0.9 1.7 4.1 -1.1 2.0 -1.7 -0.8 0.1
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.3 -0.5 -1.1 1.1 1.1 -0.5
Breast Cancer 1.5 3.6 9.3 2.3 0.7 1.1 1.2 3.0
Ovarian Cancer 0.9 1.2 2.5 1.6 0.2 1.6 0.2 1.0
Prostate Cancer 0.3 0.4 1.0 0.3 -0.8 0.5 1.0 0.3
Age at First Birth 2.1 3.0 5.6 2.4 1.9 1.9 -0.1 1.5
Bipolar Disorder (2011) 0.5 0.4 1.0 0.3 -0.5 -0.8 0.5 1.0
Body Mass Index (BMI) (2010) 0.9 1.2 2.9 0.5 1.7 0.9 -0.8 1.3
Coronary Artery Disease (CAD) 0.5 0.6 1.7 -0.6 -0.4 0.5 1.3 -0.9
Crohns Disease (2012) 0.3 0.5 1.2 -0.2 1.0 0.7 1.1 0.2
Mean Putamen Volume 0.2 0.3 0.9 -0.5 -0.5 -0.1 0.1 -0.9
Fasting Glucose 0.2 0.3 0.9 0.0 1.0 -0.6 0.1 -0.1
HbA1C 0.5 0.6 1.1 0.8 -0.2 -1.1 -0.6 -0.9
HDL Cholesterol 0.3 0.5 1.2 0.9 -0.4 -0.6 0.3 -1.1
LDL Cholesterol 0.2 0.4 0.8 -0.8 -0.6 -0.9 -0.2 -0.2
Lupus 1.4 2.1 3.2 -1.5 -1.5 -1.8 1.7 -0.0
Neuroticism (2016) 0.7 1.0 2.4 -1.5 -1.5 -0.1 0.5 -0.7
Primary Biliary Cirrhosis 0.2 0.2 0.5 0.7 0.5 -0.4 -0.0 0.4
Rheumatoid Arthritis 1.0 1.3 3.5 -1.0 -0.8 -1.9 -0.8 -0.9
Schizophrenia (2014) 0.3 0.8 1.6 -0.6 0.3 -1.2 -1.3 -0.5
Triglycerides 0.4 0.7 1.5 -1.0 -0.5 -0.2 -0.8 1.2
Type 2 Diabetes (T2D) (2012) 1.2 1.4 2.5 -1.2 -1.3 1.1 0.5 -1.6
Ulcerative Colitis 0.5 0.7 1.6 -0.4 0.7 1.3 1.2 -0.3
Blood Eosinophil Count 0.1 0.5 1.4 -1.2 -0.1 0.3 0.3 1.0
Blood Platelet Count 0.5 6.0 13.7 -2.3 -2.9 1.3 0.8 -3.7
Blood Red Count 0.1 0.8 2.8 0.5 -0.3 0.4 1.7 -0.7
Blood White Count 0.6 4.2 14.2 -1.4 -1.6 1.2 1.0 -3.8
Heel T-Score 0.2 1.6 2.6 1.4 -1.6 -0.7 1.3 1.2
BMI 0.4 2.1 4.7 -1.2 -1.5 1.2 2.2 -1.0
Height 0.3 6.7 9.8 3.1 3.0 1.2 -2.9 2.0
Waist Hip Ratio (WHR) 1.8 8.2 30.3 -2.4 -1.2 1.5 1.1 -5.5
Systolic Blood Pressure 0.3 1.3 5.9 -0.3 0.3 0.6 0.2 -2.4
Smoking Status 5.3 12.8 24.3 -4.9 -4.2 -0.9 3.7 -2.7
Allergy or Eczema 0.1 0.2 1.0 -1.0 -0.2 0.1 -0.2 0.3
Cardiovascular Disease 1.2 3.9 11.8 -3.4 -1.8 0.6 0.5 -2.0
Hypothyroidism (self reported) 0.2 0.5 1.2 0.1 -0.4 1.1 -0.2 -0.9
Respiratory disease 0.4 1.0 2.9 -0.4 -0.6 0.7 1.0 -1.7
Type 2 Diabetes (T2D) (2018) 0.2 0.3 1.1 -0.4 -0.3 0.3 -0.3 1.0
Lung FEV1/FVC ratio 0.1 0.7 1.1 1.1 0.8 -0.9 -0.8 0.2
Lung FVC 0.5 2.8 11.0 0.9 -0.2 -0.0 1.4 3.3
Neuroticism 0.3 0.7 2.3 -1.5 -0.8 -0.3 0.8 -0.1
Chronotype (morning person) 0.9 2.2 3.8 0.3 1.4 -1.8 -1.4 2.0
Hair Pigment 0.1 3.4 8.3 -0.8 -1.9 2.0 2.9 0.7
Tanning 0.2 2.4 4.2 -1.3 -2.0 1.4 2.1 0.3
Hand grip strength (left) 0.3 0.7 2.1 0.9 0.4 0.6 0.0 1.4
Number of treatments/medications taken 0.8 1.4 2.0 -1.0 -1.4 1.4 -1.1 0.9
Average weekly spirits intake 0.6 0.8 2.2 0.2 -0.7 -1.0 1.5 0.2
Sensitivity / hurt feelings 0.5 0.8 1.7 -1.0 -0.4 -0.7 1.3 0.8
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.2 -0.6 1.1 0.1 -0.5 -0.6
Hearing difficulty/problems: Yes 0.4 0.6 2.0 0.3 -0.8 0.7 0.2 -1.4
Relative age of first facial hair 0.3 0.7 3.2 -0.3 0.0 -1.8 -0.2 0.1
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 2.1 1.4 0.3 1.4 -1.3 0.6
Ever used hormone-replacement therapy (HRT) 1.1 1.4 4.8 0.6 -0.2 -2.2 -1.2 -0.5
Ever had hysterectomy (womb removed) 0.7 0.8 3.2 -0.1 -0.6 -1.8 0.3 -0.7
Systolic blood pressure, automated reading 0.1 0.2 0.5 0.4 0.3 0.2 0.5 -0.7
Eye problems/disorders: Diabetes related eye disease 2.3 2.6 4.9 2.2 1.7 1.5 -1.0 1.3
Angina 1.6 2.1 7.4 0.5 0.5 1.6 -2.7 -0.0
Medication for hormone replacement therapy 0.4 0.4 1.2 0.0 -0.8 -1.1 -0.6 -0.1
Vitamin and mineral supplements 1.2 1.6 4.6 -0.5 -0.7 2.1 1.0 -1.3
Supplements: Zinc 1.5 1.7 3.4 1.1 1.6 0.8 -0.7 1.8
Medication: Co-codamol 0.7 0.8 2.0 0.2 -1.4 -0.5 -1.3 0.6
Medication: Metformin 0.2 0.3 0.7 -0.6 -0.3 0.1 0.8 0.5
Diabetes (father) 0.4 0.5 1.0 -0.7 0.4 -0.2 1.0 0.9
Diabetes (mother) 0.2 0.3 0.7 -0.5 0.3 0.3 0.6 -0.8
Severe depression (siblings) 1.6 1.8 7.6 0.2 2.8 -0.4 -0.7 0.9
Pack years adult smoking proportion 0.4 0.6 1.1 -0.8 -0.6 -0.9 -0.5 -1.0
Impedance of leg (right) 0.6 2.9 8.0 -2.0 -1.5 -0.6 0.5 -2.8
Leg fat-free mass (left) 0.4 2.0 3.1 1.8 1.6 1.4 -0.9 1.2
Trunk fat percentage 0.4 1.4 4.9 -2.2 -0.3 1.0 0.7 -0.9
Hand grip strength (right) 0.5 1.5 4.6 1.3 1.0 0.5 0.0 2.1
Townsend deprivation index at recruitment 2.6 3.6 13.0 -3.6 -2.0 -1.0 -0.3 -0.2
Current tobacco smoking 2.3 3.8 11.2 -3.3 -1.6 -1.9 0.8 -1.0
Average weekly fortified wine intake 2.3 2.7 6.7 1.4 2.2 -2.6 -0.5 0.2
Maternal smoking around birth 3.9 5.6 12.9 -3.6 -2.3 0.4 0.9 -2.9
Fed-up feelings 0.5 0.9 3.3 0.4 0.1 0.5 -1.8 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 3.7 -1.0 0.3 0.7 -0.4 -1.9
Relative age voice broke 0.2 0.4 0.8 -0.1 -0.9 -0.7 0.5 -0.4
Taking other prescription medications 0.1 0.1 0.5 0.1 -0.7 -0.3 -0.2 0.1
Age when periods started (menarche) 0.8 2.0 7.4 1.1 1.1 -0.2 -0.6 2.7
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 3.5 0.5 -0.6 -1.9 0.9 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.5 0.8 -0.5 -0.3 0.9 1.2
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.3 1.2 -0.4 0.7 0.4 0.1
Qualifications: CSEs or equivalent 3.0 4.0 8.3 -2.9 -1.6 -0.1 1.2 -2.8
Serious illness, injury or assault to yourself 0.3 0.4 0.7 -0.0 -0.7 0.7 -0.9 -0.4
High blood pressure 0.3 0.8 3.4 -1.8 -0.1 0.6 -0.3 -0.2
Hayfever, allergic rhinitis or eczema 0.1 0.1 0.4 -0.0 0.2 0.3 -0.7 -0.2
Multivitamins +/- minerals 1.2 1.5 5.5 -1.0 -0.6 -2.3 -0.4 0.7
Stomach or abdominal pain in last month 0.9 1.1 3.2 -0.6 -1.3 0.2 -0.2 -1.8
Supplements: Glucosamine 0.9 1.2 5.1 0.7 0.5 -0.4 -2.2 0.2
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.8 -0.9 -0.6 0.4 0.1 0.3
Medication: Atenolol 0.4 0.5 1.5 0.6 0.5 -0.4 0.1 1.2
Medication: Levothyroxine sodium 0.3 0.5 1.8 -0.4 -1.4 0.7 0.3 0.4
Sitting height 0.2 1.3 5.5 2.4 -0.3 0.2 -1.0 0.3
Chronic bronchitis/emphysema (father) 2.7 3.2 8.5 -0.9 -2.9 -0.7 0.4 -2.5
High blood pressure (mother) 0.6 0.8 3.1 -0.1 -0.8 1.8 -0.5 0.3
Body mass index (BMI) 0.2 1.0 2.4 -1.5 -0.4 0.6 1.2 -0.9
Impedance of leg (left) 0.6 2.9 7.2 -2.0 -1.8 0.1 0.5 -2.7
Leg predicted mass (left) 0.4 2.1 3.5 1.9 1.7 1.3 -1.0 1.3
Trunk fat mass 0.2 0.7 1.7 -1.2 0.1 1.3 0.2 -0.5
Waist circumference 0.7 2.6 7.4 -1.7 -0.5 1.4 0.8 -2.7
Number of incorrect matches in round 0.4 0.6 1.9 1.0 -0.3 0.1 -0.1 1.4
Past tobacco smoking 5.0 9.2 16.0 3.1 3.7 -1.4 -4.0 2.0
Alcohol usually taken with meals 7.7 12.5 25.0 5.0 4.5 0.1 -2.7 3.2
Nervous feelings 0.3 0.6 1.3 -0.8 -0.0 0.5 1.2 -1.0
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.2 -0.6 0.2 -1.1 -0.5 -0.3
Hearing difficulty/problems with background noise 0.2 0.4 0.7 -0.5 -0.5 -0.9 0.8 0.3
Hair/balding pattern: Pattern 2 6.8 8.7 32.4 -2.6 -2.0 -0.0 5.7 -0.6
Had menopause 0.4 0.6 1.7 -0.3 0.9 -1.3 -0.4 0.2
Had other major operations 0.5 0.6 2.5 -0.1 -0.1 -1.6 0.6 0.2
Forced vital capacity (FVC) 0.9 3.6 9.8 2.5 1.2 0.1 0.6 3.1
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.8 0.7 -1.0 -0.4 0.5 1.4
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.0 -0.3 0.7 0.9 -0.8 1.0
Qualifications: None of the above 1.9 4.1 8.5 -2.9 -2.7 0.0 1.1 -1.9
Financial difficulties in last 2 years 2.0 2.6 7.3 -2.7 -1.3 -1.0 0.6 -1.7
Mouth/teeth dental problems 0.8 1.3 4.1 -0.0 -0.2 1.5 0.3 -2.0
Heart attack 0.4 0.5 1.4 0.1 0.3 1.2 -0.9 0.4
Allergy 0.4 0.8 2.6 -0.4 -0.7 -0.7 1.6 0.6
Pain all over the body in last month 0.6 0.7 2.3 -0.9 0.1 -0.1 0.3 1.5
Diabetes (self-reported) 0.6 0.9 3.6 -0.3 -0.1 -0.7 0.4 1.9
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.6 -0.4 0.8 0.7 -0.1 0.4
Medication: Ramipril 1.3 1.7 6.6 -0.9 0.5 2.6 0.0 0.8
Medication: Simvastatin 0.7 1.0 2.9 -1.1 -0.6 -0.4 0.3 -1.7
Fluid intelligence score 0.3 0.7 1.4 0.7 0.8 1.2 0.9 0.0
Illnesses of siblings 0.3 0.5 1.5 -1.2 -0.3 -0.6 0.3 0.5
Neuroticism score 0.2 0.5 1.9 -1.4 -0.2 -0.4 -0.5 -0.5
Weight 0.1 0.6 2.3 0.2 0.8 1.5 -0.1 -0.2
Impedance of arm (right) 0.1 0.6 2.8 -1.7 0.2 -0.5 -0.1 -0.2
Arm fat percentage (right) 0.4 1.5 5.4 -2.3 -0.4 0.5 1.2 -0.6
Trunk fat-free mass 0.6 3.2 9.8 3.1 1.6 1.1 -1.4 0.7
Hip circumference 0.0 0.2 0.4 -0.4 0.7 0.4 -0.3 -0.2
Time employed in main current job 0.7 0.8 2.2 -1.0 -0.6 1.5 0.5 0.5
Alcohol intake versus 10 years previously 0.9 1.4 2.9 0.7 0.3 1.3 1.3 1.7
Father’s age at death 1.2 1.6 6.4 0.5 1.1 -0.0 -0.3 2.5
Worrier / anxious feelings 0.3 0.6 1.6 -1.3 -0.1 0.4 0.8 -0.9
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.7 1.3 -0.8 1.0 -0.4 -0.7 -1.1
Falls in the last year 1.2 1.6 3.7 -1.5 -1.9 -0.8 0.4 -1.2
Hair/balding pattern: Pattern 3 8.3 12.4 42.0 3.0 2.7 -1.5 -6.5 1.3
Number of live births 0.6 0.8 1.6 -0.2 -0.7 1.2 1.3 0.6
Forced expiratory volume in 1-second (FEV1) 1.1 3.8 9.2 2.8 1.4 0.3 0.4 3.0
Pulse rate 1.8 3.1 6.9 -1.5 -2.6 0.2 -0.5 -2.5
Happiness 2.2 2.7 5.9 0.8 2.4 0.1 -2.4 1.2
Noisy workplace 0.3 0.3 1.3 -0.2 1.1 0.6 0.1 0.1
Qualifications: A levels/AS levels or equivalent 2.6 5.7 11.0 3.3 2.9 -0.8 -2.6 1.3
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.5 -0.7 -0.5 -0.6 -0.4 -0.5
Mouth/teeth dental problems: Dentures 0.3 0.5 1.6 -0.2 0.0 -1.0 0.2 1.2
Asthma 0.2 0.3 1.0 1.0 -0.3 0.1 -0.1 -0.8
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 4.2 0.3 -0.2 0.6 -2.1 0.7
Medication: Cholesterol lowering 1.7 2.6 9.1 -1.5 -3.0 0.8 0.8 -0.6
Depression (self-reported) 0.3 0.4 1.0 -0.8 -0.1 0.5 0.1 1.0
Medication: Lansoprazole 0.3 0.4 0.9 -1.0 -0.4 0.1 0.8 0.1
Prospective memory result 1.1 1.3 2.2 1.1 1.1 1.2 -1.5 0.6
Lung cancer (father) 0.4 0.5 1.2 0.4 0.5 -0.8 0.6 -1.1
Illnesses of mother 0.5 0.6 2.1 -0.2 1.0 -1.4 -0.2 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.1 8.2 2.9 1.3 0.3 1.1 2.1
Pulse wave Arterial Stiffness index 1.0 1.2 2.2 0.6 1.1 -0.9 -1.5 1.1
Impedance of arm (left) 0.1 0.5 2.6 -1.6 0.2 0.0 -0.1 -0.3
Arm fat mass (right) 0.2 0.9 2.6 -1.6 0.0 0.8 0.9 -0.7
Trunk predicted mass 0.5 3.1 9.5 3.1 1.5 1.1 -1.4 0.7
Standing height 0.6 6.1 12.8 3.6 2.3 1.7 -2.8 1.2
Length of working week for main job 0.9 1.0 4.1 0.6 2.0 -0.2 0.1 -0.5
Exposure to tobacco smoke at home 0.6 0.6 1.5 0.8 0.7 0.3 -0.6 1.2
Breastfed as a baby 0.6 0.7 1.7 0.8 1.3 -0.7 0.6 0.7
Tense / ‘highly strung’ 1.0 1.7 3.2 0.5 1.7 0.3 -1.5 1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 2.2 -1.5 -1.2 -1.2 0.4 -0.4
Hair/balding pattern: Pattern 4 2.0 4.8 11.8 -1.6 -3.4 1.3 2.4 -1.6
Birth weight of first child 0.3 0.6 1.7 -0.2 -0.4 1.3 0.9 0.2
Peak expiratory flow (PEF) 0.3 0.7 2.1 1.4 0.5 -0.2 0.6 1.0
Pulse wave reflection index 1.8 2.2 7.0 0.8 2.6 0.5 -0.4 1.7
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.4 -1.2 -0.2 0.0 0.7 1.1
Loud music exposure frequency 1.1 1.2 4.9 -0.8 -0.1 -0.6 2.2 0.2
Qualifications: O levels/GCSEs or equivalent 1.8 2.9 6.9 2.6 2.2 0.0 -1.2 1.0
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.4 0.2 -0.0 -0.6 0.6 -0.6
Blood clot in the leg (DVT) 1.0 1.3 2.2 -1.2 -0.2 -1.4 -0.8 -1.5
Medication: Paracetamol 1.1 1.8 7.3 -1.2 -0.1 -0.2 -2.7 -0.8
Headache pain in last month 0.5 0.8 3.5 -0.2 0.3 -0.5 0.6 1.9
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 2.4 0.9 1.5 -1.3 -0.1 0.2
Glaucoma (self-reported) 0.7 0.8 2.0 0.9 -0.6 -0.5 -0.8 1.4
Gout (self-reported) 1.7 2.3 5.8 -2.4 -2.0 -0.1 0.3 -1.2
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 2.7 -0.4 -1.4 1.6 -0.2 -0.8
Medication: Amlodipine 0.9 1.3 4.8 -2.2 -0.7 -0.4 -0.0 -0.9
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.6 0.3 -0.1 -0.8 0.4 0.1
Birth weight 0.1 0.2 0.6 0.1 -0.3 0.3 0.8 -0.0
Chronic bronchitis/emphysema (mother) 1.7 2.0 6.0 -1.7 -0.6 0.6 -0.4 -2.5
High blood pressure (siblings) 1.2 1.7 4.6 2.1 1.2 0.4 -1.5 0.6
Forced vital capacity (FVC), Best measure 1.0 3.6 9.4 3.1 1.6 0.3 0.8 2.3
Body fat percentage 0.5 1.8 5.5 -2.4 -0.6 0.9 1.1 -1.2
Leg fat percentage (right) 0.9 3.4 7.6 -2.8 -1.3 0.7 1.0 -2.5
Arm fat-free mass (right) 0.4 2.0 5.3 2.3 1.2 1.6 -0.9 0.2
Exposure to tobacco smoke outside home 0.2 0.3 1.1 -1.0 -0.4 0.2 -0.3 -0.4
Comparative body size at age 10 0.7 1.9 4.7 -0.5 2.2 -0.3 -1.3 1.7
Number of full brothers 1.0 1.3 4.4 -0.4 -0.6 0.8 1.0 -2.1
Worry too long after embarrassment 0.1 0.1 0.3 -0.5 -0.2 -0.6 0.1 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.6 0.3 -0.3 0.4 0.8 -0.7
Wheeze or whistling in the chest in last year 0.7 1.3 3.9 -1.0 -0.7 -0.3 -0.9 -2.0
Number of children fathered 0.7 0.8 2.3 1.5 0.3 0.9 -0.8 0.4
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.8 4.6 0.5 -0.5 0.7 -1.8 -2.1
Age at first live birth 0.5 1.0 2.2 1.2 0.6 1.5 -0.6 0.6
Pulse wave peak to peak time 0.9 1.0 2.2 -0.3 -1.0 1.0 1.5 -0.9
Health satisfaction 0.9 1.1 3.9 -0.3 0.9 1.0 -2.0 0.2
Shortness of breath walking on level ground 0.5 0.6 2.7 -0.0 -0.1 0.3 0.1 -1.6
Qualifications: College or University degree 4.2 13.2 24.2 4.5 4.9 0.0 -4.7 0.5
Eye problems/disorders: None of the above 3.9 4.6 9.0 -3.0 -2.7 -0.5 2.2 -1.2
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.7 -0.8 -0.4 0.2 0.7 0.4
Emphysema/chronic bronchitis 2.4 2.7 8.6 1.2 1.0 0.7 -2.9 -1.5
Medication for pain relief, constipation, heartburn 1.2 2.1 5.8 1.5 1.2 -0.8 2.4 -0.5
Neck or shoulder pain in last month 1.7 2.4 3.8 0.9 1.8 -2.0 -1.8 1.1
Medication: Blood pressure 0.5 0.9 2.7 -0.8 -0.7 1.7 -0.9 0.0
Angina (self-reported) 1.6 2.1 7.2 0.5 0.5 1.6 -2.7 -0.0
Migraine (self-reported) 0.6 0.7 0.9 -0.8 -0.9 -0.7 0.9 0.8
Medication: Ibuprofen 0.7 0.8 2.4 -0.4 -0.6 0.9 -1.6 0.8
Medication: Allopurinol 2.7 3.6 10.0 -3.2 -2.3 0.6 0.7 -1.3
Medication: Omeprazole 0.3 0.4 1.2 0.5 -0.5 0.2 0.1 -1.1
Medication: Seretide 50 evohaler 0.7 0.8 1.9 0.5 -1.0 1.4 -0.6 -0.4
Mean time to correctly identify matches 0.9 1.6 3.4 -1.6 1.1 -1.8 -1.0 0.1
Heart disease (mother) 0.4 0.5 1.3 -0.1 -0.1 0.6 0.8 1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 3.2 -1.6 -0.6 -0.3 0.9 1.8
Whole body fat mass 0.2 0.8 1.7 -1.2 0.1 1.3 0.4 -0.7
Leg fat mass (right) 0.2 0.9 1.8 -1.3 -0.4 0.9 0.4 -1.4
Arm predicted mass (right) 0.3 1.7 4.6 2.1 0.9 1.4 -1.0 0.2
Pulse rate, automated reading 2.1 6.9 15.7 -2.8 -3.3 -0.1 -0.1 -4.0
Alcohol intake frequency. 0.1 0.3 0.6 0.5 -0.6 -0.1 0.8 0.2
Comparative height size at age 10 0.1 0.3 1.0 0.3 0.8 -0.0 -1.0 0.2
Number of full sisters 1.0 1.2 3.6 0.4 -1.5 -1.9 -0.0 -0.2
Suffer from ‘nerves’ 1.1 1.7 3.5 -1.5 -0.5 0.9 1.9 1.3
Overall health rating 0.3 0.7 1.8 -0.7 -1.3 -0.3 -0.6 -0.9
Chest pain or discomfort 0.1 0.2 0.6 0.2 0.4 -0.1 -0.4 -0.8
Had major operations 0.4 0.5 1.4 -0.1 -0.8 1.2 -0.0 0.6
Age at last live birth 0.8 1.2 2.2 1.5 0.4 1.5 0.5 1.1
Family relationship satisfaction 1.5 1.9 6.1 0.2 1.7 -0.4 -2.5 0.4
Leg pain on walking 0.8 1.0 2.2 -0.4 -1.2 -0.3 1.5 1.0
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 4.0 -0.3 -2.0 -0.9 0.8 0.8
Commuting to job workplace: Car/motor vehicle 1.4 1.6 4.6 -0.1 -2.1 1.1 0.7 -1.3
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 1.7 1.3 1.2 0.9 0.7 1.3
Medication: Aspirin 0.6 0.8 1.8 -0.3 -0.4 0.8 -1.2 1.3
Supplements: Vitamin C 2.0 2.3 5.6 2.4 1.9 1.0 -0.7 1.0
Knee pain experienced in last month 1.0 1.6 3.5 -1.3 -1.9 -0.2 1.0 -1.4
Hypertension (Self-reported) 0.2 0.5 1.7 -1.3 0.1 0.6 -0.5 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.9 0.0 0.3 -0.6 -1.0 0.2
Illnesses of father: Heart disease 0.5 0.7 2.8 -1.7 -0.6 0.4 0.4 -0.3
Illnesses of siblings: Diabetes 0.5 0.6 1.2 -1.1 -0.6 0.2 0.9 -0.7
Smoking status: Previous 5.1 7.7 19.4 -2.2 -3.5 0.9 4.4 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 1.6 -0.2 0.6 1.3 0.4 0.3
Whole body fat-free mass 0.4 2.5 6.8 2.6 1.5 1.2 -1.1 0.9
Leg fat-free mass (right) 0.4 2.4 3.8 2.0 1.7 1.5 -1.0 1.3
Arm fat percentage (left) 0.4 1.7 6.0 -2.4 -0.5 0.7 1.1 -0.8
Average weekly red wine intake 5.2 7.6 14.4 3.8 3.3 -1.1 -1.6 3.0
Handedness (chirality/laterality): Left-handed 1.3 1.6 6.3 2.5 0.9 0.7 -0.2 -0.2
Mood swings 0.8 1.4 4.3 -1.0 0.1 -2.1 1.0 1.0
Loneliness, isolation 0.7 1.0 3.0 0.3 1.7 -0.0 -1.4 -0.1
Long-standing illness, disability or infirmity 0.2 0.3 0.7 0.5 -0.2 0.8 -0.4 0.5
Ever had bowel cancer screening 0.4 0.5 0.9 -0.2 -0.7 0.9 -0.8 0.5
Diabetes diagnosed by doctor 0.2 0.3 1.0 0.0 -0.5 -0.2 -0.5 1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.3 -0.1 0.0 0.4 0.3 0.6
Friendships satisfaction 1.0 1.2 4.1 0.7 2.0 -0.7 -1.0 0.3
Qualifications: nursing, teaching 1.5 2.3 4.3 1.4 1.9 0.7 -2.1 1.1
Commuting to job workplace: Walk 2.4 2.6 8.9 1.2 3.0 -0.3 -1.3 0.9
Eye problems/disorders: Cataract 0.5 0.6 1.4 0.4 1.2 0.8 -0.8 -0.1
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 3.2 1.0 1.2 -1.0 -1.0 1.8
Medication for cholesterol 0.6 1.0 1.9 0.8 -0.9 0.2 1.2 1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.2 2.9 -0.5 -0.2 -1.7 -1.1 -1.3
Back pain experienced in last month 0.9 1.3 3.1 -0.4 -0.6 -0.2 -1.8 -1.7
Mineral and other dietary supplements 1.1 1.5 2.6 -1.6 -0.6 0.2 1.6 -1.5
Breast cancer (self-reported) 2.8 3.3 5.4 -1.5 -2.1 -0.3 2.3 -2.1
Asthma (self-reported) 0.2 0.3 1.1 1.1 -0.2 -0.1 -0.1 -0.7
Osteoporosis (self-reported) 2.3 2.8 8.9 0.6 1.0 -0.6 -1.8 3.0
Osteoarthritis (self-reported) 1.1 1.4 2.0 -1.4 -1.1 1.3 0.7 -1.3
Medication: Aspirin 0.7 0.9 1.7 -0.5 -0.3 1.0 -1.2 1.3
Medication: Gliclazide 0.8 0.9 2.5 -0.9 0.0 0.7 -0.7 1.6
Illnesses of father: None of the above (group 1) 1.4 1.8 5.0 2.2 1.4 -0.2 -1.4 0.1
Smoking status: Current 1.9 3.1 10.1 -3.2 -1.1 -1.7 0.2 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.8 3.8 8.2 2.9 2.0 -0.6 0.6 2.5
Whole body water mass 0.5 2.8 6.9 2.6 1.7 1.3 -1.2 0.9
Leg predicted mass (right) 0.4 2.3 3.8 1.9 1.6 1.6 -0.9 1.4
Arm fat mass (left) 0.2 1.0 2.5 -1.6 -0.2 0.9 0.7 -0.9
Number of self-reported non-cancer illnesses 0.3 0.5 1.1 -1.1 -1.0 0.3 -0.2 -0.7
Average weekly champagne plus white wine intake 0.6 0.8 2.9 0.4 0.2 0.9 0.1 -1.7
Miserableness 0.5 0.8 2.0 -1.4 -0.3 -1.1 -0.7 -0.5
Guilty feelings 1.6 2.4 8.5 0.3 1.4 -0.9 -2.9 0.8
Wears glasses or contact lenses 1.6 1.9 4.1 1.3 0.9 -1.0 -2.0 1.4
Ever taken oral contraceptive pill 0.2 0.2 0.7 0.0 0.2 0.1 0.9 0.4
Hearing aid user 1.9 2.1 5.6 2.4 1.2 -0.8 -1.2 1.2
Mother’s age at death 0.1 0.2 0.4 0.6 0.3 0.5 0.0 0.4
Financial situation satisfaction 1.4 1.8 4.7 -2.0 -0.2 0.7 0.1 -2.2
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.7 0.1 -0.3 0.5 -0.8 0.7
Commuting to job workplace: Public transport 0.5 0.6 1.2 -0.4 1.1 -1.0 0.6 0.4
Eye problems/disorders: Glaucoma 0.7 0.8 2.5 1.0 0.2 -0.3 -1.6 0.7
Medication: Blood pressure 0.8 1.5 3.5 -0.4 1.9 1.6 -1.1 -0.1
Pain type(s) experienced in last month: Hip pain 1.1 1.4 2.9 -0.6 -1.7 -0.7 0.6 -1.7
Supplements: Fish oil (including cod liver oil) 1.3 1.7 2.9 1.2 0.8 -1.7 -1.1 1.6
High cholesterol (Self-reported) 1.1 1.9 4.7 -1.9 -1.1 0.1 -0.1 -2.2
Medication: Bendroflumethiazide 0.3 0.5 0.9 -0.7 0.7 0.1 -0.9 -0.9
Medication: Paracetamol 1.3 2.0 7.3 -1.1 0.9 0.4 -2.7 -0.5
Medication: Lisinopril 0.3 0.4 0.8 -0.8 0.6 0.5 -0.1 0.9
Medication: Atorvastatin 1.1 1.4 3.7 1.3 0.1 -0.5 -1.9 1.1
Illnesses of father: High blood pressure 0.5 0.6 1.1 1.0 0.6 1.1 -0.5 0.4
Alcohol drinker status: Never 1.3 1.6 3.9 1.1 2.0 -0.4 0.3 1.6
Ever smoked 5.7 10.0 13.8 -3.5 -3.6 2.0 3.7 -2.8
Basal metabolic rate 0.3 1.9 4.1 2.0 1.5 1.4 -0.9 0.6
Leg fat percentage (left) 1.0 3.5 7.9 -2.8 -1.5 1.0 0.9 -2.4
Arm fat-free mass (left) 0.3 1.3 3.4 1.9 1.0 1.2 -0.9 0.0
Number of operations (self-reported) 0.6 1.0 3.4 0.9 -0.7 -1.8 0.2 -0.1
Average weekly beer plus cider intake 8.1 11.7 23.6 -4.9 -4.3 0.7 2.4 -3.2
Irritability 0.4 0.7 2.0 -1.4 -0.8 -0.3 -0.4 -0.9
Risk taking 0.6 0.9 2.8 -0.0 -0.8 -1.7 -0.8 0.7
Ever had prostate specific antigen (PSA) test 1.7 1.9 5.5 2.4 0.5 0.0 -0.7 1.8
Fractured/broken bones in last 5 years 0.6 0.7 1.3 0.5 -0.5 -1.1 0.9 1.0
Age started oral contraceptive pill 1.9 2.3 5.3 2.2 2.3 0.9 -0.9 0.2
Diastolic blood pressure, automated reading 0.3 0.9 1.9 -0.7 -1.4 -0.7 -0.0 -1.3
Ever depressed for a whole week 0.5 0.6 2.2 -1.5 0.0 0.8 -0.5 -0.2
Unable to work because of sickness or disability 0.6 0.8 1.6 -1.2 0.3 0.9 -0.5 -1.2
Commuting to job workplace: Cycle 4.0 4.8 8.8 2.0 1.4 -3.0 -1.2 2.9
Myopia 6.2 9.0 19.2 3.2 2.8 1.5 -4.4 2.4
Vascular/heart problems diagnosed by doctor 0.5 1.3 4.0 2.0 0.4 -1.3 0.6 0.8
Cholesterol lowering medication 1.0 1.5 3.1 -0.7 1.3 -0.6 -1.3 -1.8
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.9 0.1 -0.8 0.2 -0.3 -1.0
Pain experienced in last month 1.0 1.7 3.6 1.9 1.4 1.4 -0.4 1.0
Supplements: Calcium 1.9 2.1 3.9 0.0 1.2 -2.0 -1.1 2.0
Basal cell carcinoma (self-reported) 1.2 1.4 3.1 -0.1 -1.2 -1.6 1.8 -0.2
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.0 -0.1 0.4 1.0 -0.9 0.2
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 1.9 -1.4 -0.2 -1.0 -0.2 -1.2
Heart disease (siblings) 0.5 0.6 1.6 0.2 0.1 1.2 0.4 -1.3
Alcohol drinker status: Previous 0.7 0.8 2.3 -1.5 -1.2 -0.2 0.5 -0.4
Pack years of smoking 0.5 0.7 1.1 -0.6 -0.8 -1.1 -0.8 -0.8
Impedance of whole body 0.3 1.5 4.2 -2.1 -0.7 -0.1 0.1 -1.6
Leg fat mass (left) 0.3 1.0 1.8 -1.3 -0.5 1.1 0.4 -1.3
Arm predicted mass (left) 0.4 1.8 5.1 2.3 1.2 1.2 -1.0 0.0