Hub : Traits :

Hair/balding pattern: Pattern 3

369 significantly associated models · 39 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 31589414 33081584 1 1 3.6e-07 1.7e-11 7.5e-06 56 SPAST
2 3 138380069 139954262 2 3 3.2e-17 4.5e-51 1.4e-25 52 RBP1 RP11-219D15.3
3 4 80407869 82578407 3 3 8.2e-14 1.3e-13 1.0e+00 100 C4orf22 FGF5 PRDM8
4 6 125970401 127355237 1 1 1.2e-09 1.5e-12 1.1e-04 70 CENPW
5 7 18364750 19854141 1 1 5.7e-20 3.8e-30 7.2e-12 64 TWIST1
6 13 100044673 101879559 1 1 9.0e-11 5.1e-11 7.2e-03 83 PCCA
7 17 42607368 45796313 27 2 1.7e-23 1.5e-22 1.0e+00 100 KANSL1 LRRC37A
8 20 20990627 22430527 2 2 1.8e-39 1.4e-92 8.9e-54 43 PAX1 RPL41P1
9 20 32437554 33844938 1 1 4.2e-07 6.2e-07 1.0e+00 100 MAP1LC3A

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Irritable Bowel Disease (IBD) 1.21 1 0 0.0 0.00 1.0e+00 CENPW
Verbal and Numeric Reasoning (VNR) 1.59 1 0 0.0 0.00 1.0e+00 CENPW
Breast Cancer 2.24 2 0 0.0 0.00 1.0e+00 KANSL1 LRRC37A
Ovarian Cancer 4.56 2 2 6.1 0.00 1.0e+00 KANSL1 LRRC37A
Mean Putamen Volume 2.23 1 0 0.0 0.00 1.0e+00 KANSL1
HDL Cholesterol 1.12 1 0 0.0 0.00 1.0e+00 MAP1LC3A
Primary Biliary Cirrhosis 1.83 1 0 0.0 0.00 1.0e+00 KANSL1
Blood Eosinophil Count 2.26 2 2 6.1 0.00 1.0e+00 KANSL1 LRRC37A
Blood Platelet Count 0.18 1 0 0.0 0.00 1.0e+00 KANSL1
Blood Red Count 5.84 5 3 9.1 0.72 1.7e-01 C4orf22 CENPW FGF5 KANSL1 LRRC37A
Blood White Count 1.09 3 1 3.0 0.00 1.0e+00 CENPW KANSL1 MAP1LC3A
Heel T-Score 2.73 5 4 12.1 -0.95 1.2e-02 KANSL1 LRRC37A MAP1LC3A SPAST TWIST1
BMI 0.94 2 0 0.0 0.00 1.0e+00 C4orf22 FGF5
Height 4.93 6 5 15.2 -0.20 7.1e-01 CENPW KANSL1 LRRC37A MAP1LC3A RPL41P1 SPAST
Waist Hip Ratio (WHR) 2.43 3 3 9.1 0.00 1.0e+00 CENPW KANSL1 LRRC37A
Systolic Blood Pressure 5.05 5 3 9.1 -0.58 3.0e-01 C4orf22 FGF5 KANSL1 LRRC37A PRDM8
Smoking Status 2.93 3 0 0.0 0.00 1.0e+00 KANSL1 LRRC37A MAP1LC3A
Allergy or Eczema 1.12 1 0 0.0 0.00 1.0e+00 MAP1LC3A
Cardiovascular Disease 4.46 3 2 6.1 0.00 1.0e+00 C4orf22 FGF5 PRDM8
Type 2 Diabetes (T2D) 1.73 1 0 0.0 0.00 1.0e+00 CENPW
Lung FEV1/FVC ratio 1.96 4 2 6.1 -0.89 1.1e-01 CENPW KANSL1 LRRC37A MAP1LC3A
Lung FVC 6.83 5 5 15.2 -0.63 2.6e-01 CENPW KANSL1 LRRC37A MAP1LC3A TWIST1
Neuroticism 6.98 3 2 6.1 0.00 1.0e+00 CENPW KANSL1 LRRC37A
Hair Pigment 2.41 7 5 15.2 -0.43 3.4e-01 C4orf22 CENPW FGF5 KANSL1 MAP1LC3A RPL41P1 TWIST1
Tanning 3.62 2 1 3.0 0.00 1.0e+00 KANSL1 MAP1LC3A
Hand grip strength (left) 4.20 4 3 9.1 0.73 2.7e-01 CENPW KANSL1 LRRC37A MAP1LC3A
Sensitivity / hurt feelings 6.30 2 2 6.1 0.00 1.0e+00 KANSL1 LRRC37A
Frequency of depressed mood in last 2 weeks 2.46 1 0 0.0 0.00 1.0e+00 KANSL1
Relative age of first facial hair 10.02 6 3 9.1 -0.96 2.1e-03 C4orf22 FGF5 KANSL1 LRRC37A SPAST TWIST1
Systolic blood pressure, automated reading 4.13 3 2 6.1 0.00 1.0e+00 C4orf22 FGF5 KANSL1
Impedance of leg (right) 1.13 1 0 0.0 0.00 1.0e+00 KANSL1
Leg fat-free mass (left) 2.63 2 2 6.1 0.00 1.0e+00 CENPW MAP1LC3A
Trunk fat percentage 2.20 3 2 6.1 0.00 1.0e+00 CENPW KANSL1 LRRC37A
Hand grip strength (right) 3.66 3 2 6.1 0.00 1.0e+00 KANSL1 LRRC37A MAP1LC3A
Fed-up feelings 3.08 2 1 3.0 0.00 1.0e+00 KANSL1 LRRC37A
Relative age voice broke 4.63 2 2 6.1 0.00 1.0e+00 KANSL1 LRRC37A
Age when periods started (menarche) 2.78 1 1 3.0 0.00 1.0e+00 CENPW
Qualifications: CSEs or equivalent 2.30 1 0 0.0 0.00 1.0e+00 KANSL1
High blood pressure 5.06 3 2 6.1 0.00 1.0e+00 C4orf22 FGF5 PRDM8
Medication: Atenolol 2.07 1 0 0.0 0.00 1.0e+00 C4orf22
Sitting height 7.50 7 4 12.1 0.26 5.7e-01 CENPW KANSL1 LRRC37A MAP1LC3A PAX1 SPAST TWIST1
High blood pressure (mother) 2.76 1 0 0.0 0.00 1.0e+00 C4orf22
Impedance of leg (left) 1.33 4 0 0.0 0.70 3.0e-01 CENPW KANSL1 LRRC37A MAP1LC3A
Leg predicted mass (left) 2.62 2 2 6.1 0.00 1.0e+00 CENPW MAP1LC3A
Trunk fat mass 1.48 3 0 0.0 0.00 1.0e+00 KANSL1 LRRC37A MAP1LC3A
Past tobacco smoking 3.32 4 0 0.0 -0.15 8.5e-01 KANSL1 LRRC37A MAP1LC3A PCCA
Nervous feelings 3.88 3 2 6.1 0.00 1.0e+00 CENPW KANSL1 LRRC37A
Frequency of tenseness / restlessness in last 2 weeks 3.40 2 1 3.0 0.00 1.0e+00 KANSL1 LRRC37A
Hearing difficulty/problems with background noise 2.19 1 0 0.0 0.00 1.0e+00 KANSL1
Hair/balding pattern: Pattern 2 18.41 9 6 18.2 -0.97 2.3e-05 C4orf22 CENPW FGF5 KANSL1 LRRC37A PCCA PRDM8 RPL41P1 TWIST1
Forced vital capacity (FVC) 6.47 3 3 9.1 0.00 1.0e+00 CENPW KANSL1 LRRC37A
Ever unenthusiastic/disinterested for a whole week 2.44 1 0 0.0 0.00 1.0e+00 KANSL1
Qualifications: None of the above 1.58 1 0 0.0 0.00 1.0e+00 CENPW
Diabetes (self-reported) 1.23 1 0 0.0 0.00 1.0e+00 CENPW
Neuroticism score 5.40 3 2 6.1 0.00 1.0e+00 CENPW KANSL1 LRRC37A
Weight 1.69 2 2 6.1 0.00 1.0e+00 CENPW MAP1LC3A
Impedance of arm (right) 1.95 4 2 6.1 0.74 2.6e-01 CENPW KANSL1 LRRC37A MAP1LC3A
Arm fat percentage (right) 1.64 1 1 3.0 0.00 1.0e+00 CENPW
Trunk fat-free mass 4.81 2 2 6.1 0.00 1.0e+00 CENPW MAP1LC3A
Hip circumference 1.15 1 1 3.0 0.00 1.0e+00 MAP1LC3A
Time employed in main current job 2.74 1 0 0.0 0.00 1.0e+00 KANSL1
Worrier / anxious feelings 2.79 2 1 3.0 0.00 1.0e+00 KANSL1 LRRC37A
Falls in the last year 2.66 1 0 0.0 0.00 1.0e+00 LRRC37A
Number of live births 2.21 1 0 0.0 0.00 1.0e+00 KANSL1
Forced expiratory volume in 1-second (FEV1) 5.85 3 3 9.1 0.00 1.0e+00 CENPW KANSL1 LRRC37A
Forced expiratory volume in 1-second (FEV1), Best measure 5.63 3 3 9.1 0.00 1.0e+00 CENPW KANSL1 LRRC37A
Impedance of arm (left) 2.13 5 2 6.1 0.42 4.8e-01 CENPW KANSL1 LRRC37A MAP1LC3A PAX1
Arm fat mass (right) 0.91 1 0 0.0 0.00 1.0e+00 MAP1LC3A
Trunk predicted mass 4.76 2 2 6.1 0.00 1.0e+00 CENPW MAP1LC3A
Standing height 4.95 5 3 9.1 0.17 7.9e-01 CENPW KANSL1 LRRC37A MAP1LC3A SPAST
Hair/balding pattern: Pattern 4 42.61 12 11 33.3 0.64 1.8e-02 C4orf22 CENPW FGF5 KANSL1 LRRC37A PAX1 PRDM8 RBP1 RP11-219D15.3 RPL41P1 SPAST TWIST1
Peak expiratory flow (PEF) 4.02 3 3 9.1 0.00 1.0e+00 KANSL1 LRRC37A MAP1LC3A
Medication: Paracetamol 3.64 2 2 6.1 0.00 1.0e+00 KANSL1 LRRC37A
Headache pain in last month 4.94 2 2 6.1 0.00 1.0e+00 KANSL1 LRRC37A
Medication for cholesterol, blood pressure or diabetes 2.07 1 0 0.0 0.00 1.0e+00 C4orf22
Birth weight 1.17 1 0 0.0 0.00 1.0e+00 CENPW
Forced vital capacity (FVC), Best measure 6.90 4 3 9.1 0.50 5.0e-01 CENPW KANSL1 LRRC37A TWIST1
Body fat percentage 2.15 4 1 3.0 0.90 9.6e-02 CENPW KANSL1 LRRC37A SPAST
Leg fat percentage (right) 1.89 2 1 3.0 0.00 1.0e+00 CENPW SPAST
Arm fat-free mass (right) 3.86 2 2 6.1 0.00 1.0e+00 CENPW MAP1LC3A
Number of full brothers 2.01 1 0 0.0 0.00 1.0e+00 KANSL1
Worry too long after embarrassment 2.54 1 0 0.0 0.00 1.0e+00 KANSL1
Qualifications: College or University degree 2.76 4 1 3.0 0.75 2.5e-01 CENPW KANSL1 LRRC37A PCCA
Medication for pain relief, constipation, heartburn 2.86 2 1 3.0 0.00 1.0e+00 KANSL1 LRRC37A
Medication: Blood pressure 3.18 3 1 3.0 0.00 1.0e+00 C4orf22 FGF5 PRDM8
Whole body fat mass 1.23 1 0 0.0 0.00 1.0e+00 MAP1LC3A
Arm predicted mass (right) 3.73 2 2 6.1 0.00 1.0e+00 CENPW MAP1LC3A
Pulse rate, automated reading 0.96 1 0 0.0 0.00 1.0e+00 C4orf22
Alcohol intake frequency. 3.27 2 2 6.1 0.00 1.0e+00 KANSL1 LRRC37A
Comparative height size at age 10 6.87 4 3 9.1 0.17 8.3e-01 CENPW KANSL1 LRRC37A MAP1LC3A
Suffer from 'nerves' 2.24 1 0 0.0 0.00 1.0e+00 KANSL1
Overall health rating 1.06 1 0 0.0 0.00 1.0e+00 SPAST
Supplements: Vitamin C 2.28 1 0 0.0 0.00 1.0e+00 KANSL1
Hypertension (Self-reported) 5.02 3 2 6.1 0.00 1.0e+00 C4orf22 FGF5 PRDM8
Illnesses of father: Heart disease 2.27 1 0 0.0 0.00 1.0e+00 KANSL1
Smoking status: Previous 3.97 2 0 0.0 0.00 1.0e+00 LRRC37A PCCA
Forced expiratory volume in 1-second (FEV1), predicted 2.72 2 2 6.1 0.00 1.0e+00 CENPW MAP1LC3A
Whole body fat-free mass 3.92 2 2 6.1 0.00 1.0e+00 CENPW MAP1LC3A
Leg fat-free mass (right) 2.70 2 2 6.1 0.00 1.0e+00 CENPW MAP1LC3A
Arm fat percentage (left) 1.74 2 1 3.0 0.00 1.0e+00 CENPW SPAST
Handedness (chirality/laterality): Left-handed 4.06 2 1 3.0 0.00 1.0e+00 KANSL1 LRRC37A
Mood swings 4.66 2 2 6.1 0.00 1.0e+00 KANSL1 LRRC37A
Loneliness, isolation 2.85 2 0 0.0 0.00 1.0e+00 KANSL1 LRRC37A
Diabetes diagnosed by doctor 1.71 1 0 0.0 0.00 1.0e+00 CENPW
Mouth/teeth dental problems: Mouth ulcers 3.17 2 1 3.0 0.00 1.0e+00 KANSL1 LRRC37A
Medication for cholesterol 3.31 2 0 0.0 0.00 1.0e+00 C4orf22 FGF5
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.84 2 2 6.1 0.00 1.0e+00 KANSL1 LRRC37A
Whole body water mass 3.86 2 2 6.1 0.00 1.0e+00 CENPW MAP1LC3A
Leg predicted mass (right) 2.69 2 2 6.1 0.00 1.0e+00 CENPW MAP1LC3A
Arm fat mass (left) 0.88 1 0 0.0 0.00 1.0e+00 MAP1LC3A
Average weekly champagne plus white wine intake 1.68 1 0 0.0 0.00 1.0e+00 KANSL1
Miserableness 2.94 2 1 3.0 0.00 1.0e+00 KANSL1 LRRC37A
Guilty feelings 2.86 1 0 0.0 0.00 1.0e+00 KANSL1
Medication: Blood pressure 4.55 4 2 6.1 0.45 5.5e-01 C4orf22 CENPW FGF5 KANSL1
Medication: Paracetamol 3.98 2 2 6.1 0.00 1.0e+00 KANSL1 LRRC37A
Illnesses of father: High blood pressure 3.02 1 0 0.0 0.00 1.0e+00 C4orf22
Ever smoked 2.61 1 0 0.0 0.00 1.0e+00 MAP1LC3A
Basal metabolic rate 3.32 2 2 6.1 0.00 1.0e+00 CENPW MAP1LC3A
Leg fat percentage (left) 1.93 2 1 3.0 0.00 1.0e+00 CENPW SPAST
Arm fat-free mass (left) 3.63 2 2 6.1 0.00 1.0e+00 CENPW MAP1LC3A
Irritability 2.87 2 1 3.0 0.00 1.0e+00 KANSL1 LRRC37A
Fractured/broken bones in last 5 years 2.75 1 0 0.0 0.00 1.0e+00 KANSL1
Diastolic blood pressure, automated reading 2.15 2 2 6.1 0.00 1.0e+00 C4orf22 FGF5
Myopia 2.55 2 0 0.0 0.00 1.0e+00 KANSL1 PCCA
Vascular/heart problems diagnosed by doctor 4.40 3 2 6.1 0.00 1.0e+00 C4orf22 FGF5 PRDM8
Pain experienced in last month 2.20 1 0 0.0 0.00 1.0e+00 CENPW
Impedance of whole body 1.93 4 2 6.1 0.74 2.6e-01 CENPW KANSL1 LRRC37A MAP1LC3A
Arm predicted mass (left) 3.55 2 2 6.1 0.00 1.0e+00 CENPW MAP1LC3A

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 7 0.2005 1.50
GTEx Adipose Visceral Omentum 7 0.3438 1.59
GTEx Adrenal Gland 5 0.3432 1.60
GTEx Artery Aorta 9 0.3023 1.61
GTEx Artery Coronary 9 0.7608 1.94
GTEx Artery Tibial 5 0.1329 1.44
GTEx Brain Caudate basal ganglia 5 0.5435 1.64
GTEx Brain Cerebellar Hemisphere 8 0.5373 1.70
GTEx Brain Cerebellum 6 0.3027 1.57
GTEx Brain Cortex 8 0.7729 1.79
GTEx Brain Frontal Cortex BA9 6 0.6494 1.70
GTEx Brain Hippocampus 5 0.9542 2.02
GTEx Brain Hypothalamus 6 1.0169 2.00
GTEx Brain Nucleus accumbens basal ganglia 7 0.8092 1.82
GTEx Brain Putamen basal ganglia 6 0.9615 2.03
GTEx Breast Mammary Tissue 9 0.4559 1.59
GTEx Breast Mammary Tissue (Male) 7 0.5868 1.76
GTEx Breast Mammary Tissue (Female) 10 0.6083 1.62
GTEx Cells EBV-transformed lymphocytes 11 0.7730 1.85
GTEx Cells Transformed fibroblasts 10 0.2382 1.44
GTEx Colon Sigmoid 7 0.4788 1.72
GTEx Colon Transverse 8 0.3876 1.64
GTEx Esophagus Gastroesophageal Junction 8 0.5536 1.77
GTEx Esophagus Mucosa 10 0.3012 1.53
GTEx Esophagus Muscularis 10 0.3094 1.56
GTEx Heart Atrial Appendage 7 0.4433 1.72
GTEx Heart Left Ventricle 7 0.4575 1.70
GTEx Liver 5 0.6974 1.77
GTEx Lung 9 0.3133 1.56
GTEx Muscle Skeletal 8 0.2768 1.53
GTEx Nerve Tibial 9 0.2083 1.50
GTEx Ovary 7 0.7709 1.83
GTEx Pancreas 10 0.6127 1.74
GTEx Pituitary 5 0.4484 1.66
GTEx Prostate 5 0.5988 1.77
GTEx Skin Not Sun Exposed Suprapubic 8 0.3253 1.58
GTEx Skin Sun Exposed Lower leg 9 0.2473 1.47
GTEx Small Intestine Terminal Ileum 4 0.8677 1.96
GTEx Spleen 6 0.4252 1.55
GTEx Stomach 9 0.6190 1.82
GTEx Testis 11 0.3487 1.54
GTEx Thyroid 10 0.2501 1.48
GTEx Uterus 6 1.0582 2.06
GTEx Vagina 6 0.9449 2.18
GTEx Whole Blood 6 0.3011 1.57
METSIM Adipose 1 0.0217 1.32
NTR Blood 3 0.1249 1.33
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.31
YFS Blood 1 0.0217 1.23
CommonMind Brain Pre-frontal Cortex 5 0.0930 1.35
TCGA Breast Tumor 3 0.3911 1.65
TCGA Breast Normal 5 0.1188 1.30
TCGA Ovarian Tumor 7 0.2396 1.30
TCGA Prostate Tumor 8 0.2313 1.36